cromakalim has been researched along with Muscle Contraction in 187 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 14 (7.49) | 18.7374 |
| 1990's | 137 (73.26) | 18.2507 |
| 2000's | 28 (14.97) | 29.6817 |
| 2010's | 7 (3.74) | 24.3611 |
| 2020's | 1 (0.53) | 2.80 |
| Authors | Studies |
|---|---|
| Altenbach, RJ; Bai, H; Brioni, JD; Brune, ME; Buckner, SA; Carroll, WA; Cassidy, C; Chen, Y; Coghlan, MJ; Daza, AV; Drizin, I; Fey, TA; Fitzgerald, M; Gopalakrishnan, M; Gregg, RJ; Henry, RF; Holladay, MW; King, LL; Kort, ME; Kym, PR; Milicic, I; Sullivan, JP; Tang, R; Turner, SC; Whiteaker, KL; Yi, L; Zhang, H | 1 |
| Agrios, KA; Altenbach, RJ; Buckner, SA; Carroll, WA; Chen, Y; Coghlan, MJ; Daza, AV; Drizin, I; Gopalakrishnan, M; Henry, RF; Kort, ME; Kym, PR; Milicic, I; Smith, JC; Sullivan, JP; Tang, R; Turner, SC; Whiteaker, KL; Zhang, H | 1 |
| Altenbach, RJ; Brune, ME; Buckner, SA; Carroll, WA; Coghlan, MJ; Daza, AV; Fabiyi, A; Gopalakrishnan, M; Henry, RF; Khilevich, A; Kort, ME; Milicic, I; Scott, VE; Smith, JC; Whiteaker, KL | 1 |
| Bouhedja, M; Boumendjel, A; Faury, G; Fhayli, W; Ghandour, Z; Khelili, S; Peres, B | 1 |
| Artursson, E; Bucht, A; Thors, L; Wigenstam, E | 1 |
| Clemmer, JS; Gowdey, AR; Hester, RL; Lu, S; Mittwede, PN; Xiang, L | 1 |
| Javid, FA; Palea, S | 1 |
| de Tullio, P; Desvaux, V; Florence, X; Goffin, E; Lebrun, P; Pirotte, B | 1 |
| De Keulenaer, GW; De Meyer, GR; Fransen, P; Leloup, AJ; Schrijvers, DM; Van Hove, CE | 1 |
| Akino, H; Chapple, CR; Chess-Williams, R; Cross, RL; McKay, N; Murakami, S; Sellers, DJ; Yokoyama, O | 1 |
| Borja-Oliveira, CR; Pertinhez, TA; Rodrigues-Simioni, L; Spisni, A | 1 |
| Dimitriadis, F; Kinoshita, Y; Ohmasa, F; Saito, M; Satoh, I; Satoh, K; Shimizu, S; Taniguchi, S | 1 |
| Davis, MJ; Scallan, JP; Wolpers, JH | 1 |
| Ayan-Polat, B; Kayhan, Z; Oğüş, E; Polat, G; Tecder-Unal, M; Tufan, H | 1 |
| Brioni, JD; Brune, ME; Coghlan, MJ; Fey, TA; Gopalakrishnan, M; King, LL; Strake, JG; Sullivan, JP | 1 |
| Brioni, JD; Brune, ME; Coghlan, MJ; Fabiyi, AC; Gopalakrishnan, M; Lynch, JJ | 1 |
| Doggrell, S; Hoberg, JO; Thompson, R | 1 |
| Asagba, SO; Ebeigbe, AB; Omogbai, EK; Ozolua, RI | 1 |
| Brading, AF; Hashitani, H; Suzuki, H | 1 |
| Lodge, NJ; Myers, RA; Plym, MJ; Signor, LJ | 1 |
| Aalkjaer, C; Forman, A; Glavind-Kristensen, M; Hansen, VB; Matchkov, V; Nilsson, H | 1 |
| Hong, SJ; Liang, HC; Shen, CJ | 1 |
| Ghafar, R; Gilani, AH; Jabeen, Q; Khan, AU; Subhan, F | 1 |
| Aoyama, M; Furuzono, S; Imaizumi, Y; Ito, Y; Kajioka, S; Liu, HN; Matsubara, T; Murase, N; Nakayama, S; Nishizawa, Y; Ohya, S; Wang, J; Watanabe, T | 1 |
| Brune, ME; Buckner, SA; Coghlan, M; Daza, A; Fey, TA; Gopalakrishnan, M; Milicic, I | 1 |
| de Tullio, P; Florence, X; Gall, D; Lebrun, P; Pirotte, B; Sebille, S | 1 |
| Kathirvel, K; Parija, SC; Sardar, KK; Vijayakumar, C | 1 |
| Hirota, S; Janssen, LJ | 1 |
| Badawi, JK; Bross, S; Ding, A | 1 |
| Kanwal, S; Trachte, GJ | 1 |
| Asano, M; Fujikura, T; Masuda, N; Matsumoto, Y; Shibasaki, K; Shirai, Y; Taguchi, T; Takenaka, T; Tsuzuki, R; Uchida, W | 1 |
| Asano, M; Masuzawa-Ito, K; Matsuda, T | 1 |
| Allescher, HD; Franck, H; Puschmann, A; Schusdziarra, V | 1 |
| Maggi, CA; Meini, S; Santicioli, P | 1 |
| Brock, GB; Lue, TF; Nunes, L; Riemer, RK; Tanagho, EA; von Heyden, B | 1 |
| Mellemkjaer, S; Nielsen-Kudsk, JE; Thirstrup, S | 2 |
| Allen, DG; Duty, S | 1 |
| Jino, H; Kurahashi, K; Nakata, Y; Shimizu, Y; Shirahase, H; Usui, H | 1 |
| Schwietert, R; van Zwieten, PA; Wilffert, B; Wilhelm, D | 1 |
| Groschner, K; Kühberger, E; Kukovetz, WR | 1 |
| Bourreau, JP; Daniel, EE; Kwan, CY | 2 |
| Advenier, C; Martin, CA | 1 |
| Ginkawa, M; Kontani, H; Sakai, T | 1 |
| Hohenfellner, R; Jahnel, U; Nawrath, H; Wammack, R | 2 |
| Atwal, KS; D'Alonzo, AJ; Grover, GJ; McCullough, JR; Sargent, CA | 1 |
| Satake, N; Shibata, S; Zhou, Q | 1 |
| Parsons, AA; Schilling, L; Wahl, M | 1 |
| Cai, B; deBoisblanc, B; Gillott, D; Goharderakhshan, R; Greenberg, SS; Hao, Q; Hyman, A; Lippton, H; Summer, WR | 1 |
| Giuliani, S; Maggi, CA; Santicioli, P | 2 |
| Hirano, K; Kanaide, H; Ushio-Fukai, M | 1 |
| Hou, YS; Lee, SS; Teng, CM; Yu, SM | 1 |
| Bishop, BE; Doggrell, SA | 1 |
| Criddle, DN; Greenwood, IA; Weston, AH | 1 |
| Berry, JL; Chiu, P; Cook, SJ; Downing, SJ; Foster, RW; Small, RC | 1 |
| Drew, GM; Roach, AG; Trezise, DJ; Watts, IS; Weston, AH | 1 |
| Jun, JY; Kim, KW; Kim, SJ | 1 |
| Aubier, M; Brione, E; De Vernejoul, D; Pavlovic, D | 1 |
| Advenier, C; Dumas, JP; Dumas, M; Giudicelli, JF | 1 |
| Sargent, C; Smith, MA; Weselcouch, EO; Wilde, MW | 1 |
| MacDonald, E; McDonald, A; Scott, PJ; Wadsworth, RM | 1 |
| Casis, O; Garcia Rafanell, J; Gomez, LA; Perez-Vizcaino, F; Rodriguez, R; Tamargo, J | 1 |
| Kamei, K; Kuriyama, H; Nabata, H | 1 |
| Ha, JH; Kim, WJ; Lee, KY | 1 |
| Brading, AF; Huang, SM; Katayama, N; Tomita, T | 1 |
| Brewster, M; Gater, PR; McKean, JC; Paciorek, PM; Waterfall, JF; Wilson, K | 1 |
| Marthan, R; Savineau, JP | 1 |
| D'Aguinaga, S; de Mello, RF; de Moura, RS | 1 |
| Creed, KE; Malmgren, A | 1 |
| Quast, U; Villhauer, EB | 1 |
| Bonasso, CL; Lewis, AI; Rapoport, RM; Sperelakis, N; Zuccarello, M | 1 |
| de Lemos Neto, M; de Moura, RS | 1 |
| Kelly, E; Kumar, P; Poucher, SM; Prior, H; Russell, K; Wickenden, AD | 1 |
| Karaki, H; Mitsui-Saito, M; Ozaki, H; Trongvanichnam, K | 1 |
| Bertelsen, DL; Chun, A; Kau, S; Levin, RM; Murphy, J | 1 |
| Kam, KL; Pfaffendorf, M; van Zwieten, PA | 1 |
| Advenier, C; Bakdach, H; Bonnet, PA; Cui, YY; Michel, A; Naline, E | 1 |
| Asano, M; Ito, K; Kuwako, M; Nomura, Y; Shibuya, M; Sugita, K; Suzuki, Y | 1 |
| Nielsen-Kudsk, JE | 1 |
| Hüsken, BC; Pfaffendorf, M; Timmenga, EJ; Van Zwieten, PA; Vroom, MB | 1 |
| Ballejo, G; Corrado, AP; Cruz-Höfling, MA; Heluany, NF; Leite, GB; Prado-Franceschi, J; Rodrigues-Simioni, L; Silva-Carvalho, I | 1 |
| Huang, Y; Kwok, KH | 1 |
| Burton, FL; Smith, GL | 1 |
| Ando, T; Kume, H; Takagi, K; Urata, Y | 1 |
| Chuliá, S; D'Ocon, P; Ivorra, MD; Noguera, MA | 1 |
| Kinoshita, M; Liu, Q; Matsumoto, T; Nakae, I; Omura, T; Takahashi, M; Takaoka, A | 1 |
| Van de Voorde, J; Vanheel, B | 1 |
| Hosoki, K; Karasawa, T; Nagata, S; Takeyama, K | 1 |
| Akar, F; Aşlamaci, S; Kanzik, I; Köksoy, C; Tufan, H; Uydeş-Dogan, BS | 1 |
| Armstead, WM; Kasemsri, T | 1 |
| Lee, BH; Seo, HW; Shin, HS; Yoo, SE | 1 |
| Aida, M; Saito, W; Saito, Y; Sasaki, M; Shigenobu, K; Tanaka, H; Tanaka, Y | 1 |
| Motohashi, O; Sugai, K; Suzuki, M; Yanagisawa, T; Yoshimoto, T | 1 |
| Chang, M; Cheng, C; Lee, Y; Lin, C; Sheu, J; Yen, M | 1 |
| Chang, IY; Jun, JY; Kim, KW; Kim, SJ; Yeum, CH; Yoon, PJ | 1 |
| Barbieri, A; Bianchi, L; Boselli, C; Grana, E | 1 |
| Balfagón, G; Ferrer, M; Marín, J; Tejera, N | 1 |
| Huang, Y; Lau, CW | 1 |
| Arvola, P; Hutri-Kähönen, N; Jolma, P; Kähönen, M; Nordback, I; Pörsti, I; Sand, J; Wu, X; Ylitalo, P | 1 |
| Masuda, N; Matsuhisa, A; Matsumoto, Y; Nohira, H; Shibanuma, T; Tsuzuki, R; Yamagiwa, Y; Yanagisawa, I | 1 |
| Autore, G; d'Emmanuele di Villa Bianca, R; Lippolis, L; Pinto, A; Sorrentino, L; Sorrentino, R | 1 |
| De Los Angeles, J; Jagadeesh, JM; Jing, L; Miller, DD; Patil, PN | 1 |
| Banchelli, G; Bertini, V; De Munno, A; Ghelardini, C; Lucchesini, F; Pirisino, R; Raimondi, L | 1 |
| Criddle, DN; Leal-Cardoso, JH; Santos, GC; Scarparo, HC | 1 |
| Högestätt, ED; Petersson, J; Ryman, T | 1 |
| Bourreau, JP; Huang, Y; Shen, S | 1 |
| Bonev, AD; Heppner, TJ; Herrera, GM; Nelson, MT; Petkov, GV | 1 |
| Chen, Q; Wang, XL | 1 |
| Imai, T; Koike, K; Okamoto, T; Shigenobu, K; Tanaka, H; Tanaka, Y; Yamamoto, Y | 1 |
| Hu, W; Jin, Z; Li, J; Wang, J; Wang, X; Xu, W; Yang, W | 1 |
| Barnes, PJ; Belvisi, MG; Miura, M; Stretton, CD; Yacoub, MH | 1 |
| Shikada, K; Tanaka, S | 1 |
| Cook, D; Stockbridge, N; Vollrath, B; Weir, B; Zhang, H | 1 |
| Bayguinov, O; Boev, K; Kortezova, N; Papasova, M | 1 |
| Asano, M; Ito, K; Kanno, T; Masuzawa-Ito, K; Ohashi, H; Suzuki, H; Suzuki, K; Takewaki, T | 1 |
| Huang, TF; Ko, FN; Su, MJ; Teng, CM; Wang, ML; Wu, TS; Yu, SM | 1 |
| Aikawa, T; Itabashi, S; Morikawa, M; Sasaki, H; Sekizawa, K; Takishima, T | 1 |
| Nielsen-Kudsk, JE; Thirstrup, S | 2 |
| Ichihara, K; Nagasaka, M; Okumura, K | 1 |
| Taira, N; Yamagishi, T; Yanagisawa, T | 1 |
| Alibhai, KN; Huizinga, JD; Richardson, D | 1 |
| Duty, S; Weston, AH | 1 |
| Arch, JR; Foster, KA; Newson, PN; Shaw, D; Taylor, SG | 1 |
| Andersson, PO; Criddle, D; Deitmer, P; Edwards, G; Greengrass, P; Morita, T; Noack, T; Weston, AH; Wyllie, MG | 1 |
| Eckman, DM; Frankovich, JD; Keef, KD | 1 |
| Shikada, K; Tanaka, S; Yamamoto, A | 2 |
| Kreye, VA; Pfründer, D; Theiss, U | 1 |
| Arch, JR; Bond, J; Buckle, DR; Shaw, DJ; Taylor, JF; Taylor, SG; Ward, JS | 1 |
| Bang, L; Nielsen-Kudsk, JE | 1 |
| Ashford, ML; Ben-Ari, Y; Zini, S | 1 |
| Berry, JL; Burka, JF; Foster, RW; Small, RC; Watt, AJ | 1 |
| Ito, K; Nishimura, K; Ota, M | 1 |
| Grant, TL; Zuzack, JS | 1 |
| Dwyer, TM; Farley, JM; Petrini, MF; Shieh, CC | 1 |
| de Moura, RS; Jasbik, W | 1 |
| Baumlin, Y; Quast, U | 1 |
| Ito, S; Itoh, T; Kajikuri, J; Kuriyama, H | 1 |
| Barbieri, A; Grana, E; Zonta, F | 2 |
| Cooper, J; Maclagan, J | 1 |
| Balwierczak, JL | 1 |
| Kreye, VA; Lenz, T; Theiss, U | 1 |
| Satoh, K; Taira, N; Yamada, H | 1 |
| Mundy, AR; Nurse, DE; Restorick, JM | 1 |
| Asano, M; Masuzawa, K; Matsuda, T | 2 |
| Grant, TL; Grimwood, S; Todd, MH; Wickenden, AD | 1 |
| Hirano, K; Kanaide, H; Yoshitake, K | 1 |
| Angus, JA; McPherson, GA | 2 |
| Bray, K; Quast, U | 1 |
| Fromm-Freeck, S; Hayes, L; Howe, BB; Kau, ST; Kitada, S; Levin, RM; Wein, AJ | 1 |
| Antoine, MH; Berkenboom, G; Fang, ZY; Fontaine, J; Herchuelz, A; Hermann, M; Lebrun, P | 1 |
| Taira, N; Teshigawara, T; Yanagisawa, T | 1 |
| Adeagbo, AS; Malik, KU | 1 |
| Kaneko, K; Miyata, N; Otomo, S; Tanaka, M; Tsuchida, K | 1 |
| Koch, P; Peters, T; Wilffert, B; Wilhelm, D | 1 |
| Kadlec, O; Masek, K; Seferna, I; Sevcík, J | 1 |
| Grafe, P; Lehmann-Horn, F; Quasthoff, S; Spittelmeister, W; Spuler, A | 1 |
| Andersson, KE; Andersson, PO; Fovaeus, M; Malmgren, A; Sjögren, C | 1 |
| Grafe, P; Lehmann-Horn, F; Quasthoff, S; Strupp, M | 1 |
| Andersson, KE; Fovaeus, M; Hedlund, H; Holmquist, F | 1 |
| Bühler, FR; Cauvin, C; Weir, SW | 1 |
| Dollery, CT; Turner, NC; Williams, AJ | 1 |
| Longmore, J; Weston, AH | 1 |
| den Hertog, A; Nelemans, A; Van den Akker, J | 1 |
| Eltze, M | 1 |
| Kamata, K; Kasuya, Y; Miyata, N | 1 |
| Cooper, SM; Wilson, C | 1 |
| Brading, AF; Foster, CD; Fujii, K; Speakman, MJ | 1 |
| Brading, AF; Foster, CD; Fujii, K; Kingdon, J | 1 |
| Dale, MM; Obianime, AW | 1 |
| Clapham, JC; Wilson, C | 1 |
| Quast, U | 1 |
| Shetty, SS; Weiss, GB | 1 |
| Hamilton, TC; Weir, SW; Weston, AH | 1 |
| Gericke, R; Harting, J; Lues, I; Schittenhelm, C | 1 |
| Ahmed, SZ; Atwal, KS; Dzwonczyk, S; Ferrara, FN; Grover, GJ; Normandin, DE; Sleph, PG | 1 |
| Eda, M; Fukaya, C; Gohda, M; Kosaka, K; Matzno, S; Nakamura, N; Okada, T; Ono, S; Takemoto, T | 1 |
| Brown, FJ; Ceccarelli, C; Chun, AL; Empfield, JR; Forst, JM; Frank, CA; Gibson, KH; Grant, TL; Harris, RJ; Howe, BB; Hulsizer, JM; Kau, ST; Lewis, JJ; Lin, MM; Masek, BB; Mayhugh, DR; McLaren, FM; Neilson, KL; Ohnmacht, CJ; Russell, K; Shapiro, HS; Silverman, SM; Smith, RW; Trainor, DA; Warwick, PJ | 1 |
| Ahmed, SZ; Atwal, KS; Ding, CZ; Grover, GJ; Kelly, Y; Miller, AV; Misra, RN; Normandin, DE; Rovnyak, GC; Sleph, PG | 1 |
| Brune, ME; Buckner, SA; Carroll, WA; Castle, NA; Coghlan, MJ; Daza, AV; Fabiyi, A; Gopalakrishnan, M; Milicic, I; Scott, VE; Sullivan, JP; Turner, SC; White, TK | 1 |
187 other study(ies) available for cromakalim and Muscle Contraction
| Article | Year |
|---|---|
Synthesis and structure-activity relationships of a novel series of 2,3,5,6,7,9-hexahydrothieno[3,2-b]quinolin-8(4H)-one 1,1-dioxide K(ATP) channel openers: discovery of (-)-(9S)-9-(3-bromo-4-fluorophenyl)-2,3,5,6,7,9- hexahydrothieno[3,2-b]quinolin-8(4H)
Topics: Adenosine Triphosphate; Animals; Cyclic S-Oxides; Electric Stimulation; Guinea Pigs; Hemodynamics; In Vitro Techniques; Membrane Potentials; Muscle Contraction; Muscle, Smooth; Potassium Channels; Quinolones; Stereoisomerism; Structure-Activity Relationship; Swine; Urinary Bladder; Urodynamics | 2004 |
Synthesis and structure-activity relationships of a novel series of tricyclic dihydropyridine-based KATP openers that potently inhibit bladder contractions in vitro.
Topics: Adenosine Triphosphate; Animals; Dihydropyridines; Electric Stimulation; Guinea Pigs; Hemodynamics; Heterocyclic Compounds, 3-Ring; Hydrogen Bonding; In Vitro Techniques; Membrane Potentials; Muscle Contraction; Muscle, Smooth; Potassium Channels; Stereoisomerism; Structure-Activity Relationship; Swine; Urinary Bladder; Urodynamics | 2004 |
Effects of substitution on 9-(3-bromo-4-fluorophenyl)-5,9-dihydro-3H,4H-2,6-dioxa-4- azacyclopenta[b]naphthalene-1,8-dione, a dihydropyridine ATP-sensitive potassium channel opener.
Topics: Adenosine Triphosphate; Animals; Aza Compounds; Cell Line; Crystallography, X-Ray; Dihydropyridines; Electric Stimulation; Heterocyclic Compounds, 3-Ring; In Vitro Techniques; Ion Channel Gating; Mice; Muscle Contraction; Muscle, Smooth; Naphthalenes; Potassium Channels, Inwardly Rectifying; Stereoisomerism; Structure-Activity Relationship; Swine; Urinary Bladder | 2006 |
Design, synthesis and biological evaluation of novel ring-opened cromakalim analogues with relaxant effects on vascular and respiratory smooth muscles and as stimulators of elastin synthesis.
Topics: Animals; Cromakalim; Dose-Response Relationship, Drug; Drug Design; Elastin; Female; Molecular Structure; Muscle Contraction; Muscle, Smooth; Rats; Rats, Wistar; Structure-Activity Relationship | 2018 |
Supplemental treatment to atropine improves the efficacy to reverse nerve agent induced bronchoconstriction.
Topics: Acetylcholinesterase; Animals; Atropine; Bronchoconstriction; Cromakalim; Electric Stimulation; Formoterol Fumarate; Magnesium Sulfate; Muscarinic Antagonists; Muscle Contraction; Nerve Agents; Nicotine; Rats; Tubocurarine | 2022 |
Impaired vascular KATP function attenuates exercise capacity in obese zucker rats.
Topics: Acetophenones; Animals; Cromakalim; Enzyme Inhibitors; Glyburide; Humans; Hypoglycemic Agents; Male; Muscle Contraction; NADPH Oxidases; Obesity; Physical Endurance; Potassium Channels; Rats; Rats, Zucker; Superoxides; Vasodilation; Vasodilator Agents | 2013 |
The effect of 5-HT and electrical field stimulation on the contractility of the whole isolated urinary bladder of Suncus murinus.
Topics: Adenosine Triphosphate; Animals; Atropine; Cromakalim; Electric Stimulation; Female; Glyburide; Male; Methysergide; Muscle Contraction; Phenols; Receptors, Serotonin; Serotonin; Serotonin Antagonists; Shrews; Sulfonamides; Urinary Bladder | 2014 |
Influence of the alkylsulfonylamino substituent located at the 6-position of 2,2-dimethylchromans structurally related to cromakalim: from potassium channel openers to calcium entry blockers?
Topics: Animals; Aorta; Biological Transport; Calcium; Chromans; Cromakalim; Dose-Response Relationship, Drug; Insulin; Insulin Secretion; Insulin-Secreting Cells; Ion Channel Gating; Muscle Contraction; Potassium Channels; Potassium Chloride; Rats; Stereoisomerism; Structure-Activity Relationship; Sulfur Compounds | 2014 |
Effect of angiotensin II-induced arterial hypertension on the voltage-dependent contractions of mouse arteries.
Topics: Action Potentials; Angiotensin II; Animals; Arteries; Blood Pressure; Calcium Channel Blockers; Calcium Channels, L-Type; Cromakalim; Diltiazem; Hypertension; Male; Mice; Mice, Inbred C57BL; Muscle Contraction; Muscle, Smooth, Vascular; Nitric Oxide; Potassium; Vasodilation | 2016 |
Spontaneous contractions of the pig urinary bladder: the effect of ATP-sensitive potassium channels and the role of the mucosa.
Topics: Adenosine Triphosphate; Animals; Cromakalim; Female; Fluorescent Antibody Technique; In Vitro Techniques; KATP Channels; Mucous Membrane; Muscle Contraction; Swine; Urinary Bladder | 2008 |
Positive inotropic effects of Tityus cambridgei and T. serrulatus scorpion venoms on skeletal muscle.
Topics: Acetylcholine; Animals; Cromakalim; Diaphragm; Electric Stimulation; In Vitro Techniques; Ion Channel Gating; Male; Mice; Muscle Contraction; Muscle Strength; Neuromuscular Nondepolarizing Agents; Phrenic Nerve; Potassium Channel Blockers; Potassium Channels; Scorpion Venoms; Sodium Channel Blockers; Sodium Channels; Tetrodotoxin; Time Factors; Tubocurarine | 2009 |
The role of ATP-sensitive potassium channel on acute urinary retention and subsequent catheterization in the rat.
Topics: Animals; Blood Circulation; Blood Pressure; Cromakalim; Dose-Response Relationship, Drug; Female; Glyburide; Ion Channel Gating; KATP Channels; Muscle Contraction; Nicorandil; Potassium Channel Blockers; Potassium Chloride; Rats; Rats, Sprague-Dawley; Urinary Bladder; Urinary Catheterization; Urinary Retention | 2010 |
Constriction of isolated collecting lymphatic vessels in response to acute increases in downstream pressure.
Topics: Animals; Arterioles; Constriction; Cromakalim; Lymph; Lymphatic Vessels; Male; Muscle Contraction; Muscle, Smooth; Pressure; Rats; Rats, Sprague-Dawley | 2013 |
Contractile responses of the human umbilical artery to KCl and serotonin in Ca-free medium and the effects of levcromakalim.
Topics: Calcium; Chelating Agents; Cromakalim; Egtazic Acid; Enzyme Inhibitors; Humans; Indomethacin; Muscle Contraction; Muscle, Smooth, Vascular; NG-Nitroarginine Methyl Ester; Potassium Chloride; Serotonin; Solutions; Umbilical Arteries; Vasodilator Agents | 2003 |
Effects of ATP-sensitive K+ channel openers and tolterodine on involuntary bladder contractions in a pig model of partial bladder outlet obstruction.
Topics: Adenosine Triphosphate; Animals; Benzhydryl Compounds; Benzoxazines; Cresols; Cromakalim; Cyclic N-Oxides; Disease Models, Animal; Dose-Response Relationship, Drug; Female; Ion Channel Gating; Muscarinic Antagonists; Muscle Contraction; Oxazines; Parasympatholytics; Phenylpropanolamine; Potassium Channels; Sus scrofa; Tolterodine Tartrate; Urinary Bladder; Urinary Bladder Neck Obstruction; Urodynamics | 2003 |
In vivo evaluation of the potency and bladder-vascular selectivity of the ATP-sensitive potassium channel openers (-)-cromakalim, ZD6169 and WAY-133537 in rats.
Topics: Amides; Animals; Benzophenones; Calcium Channels; Cromakalim; Cyclobutanes; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Female; Male; Muscarinic Antagonists; Muscle Contraction; Nitriles; Rats; Rats, Sprague-Dawley; Reflex, Abnormal; Urinary Bladder; Urinary Bladder Neck Obstruction; Urinary Bladder, Neurogenic; Vasodilator Agents | 2003 |
Potassium channel activators based on the benzopyran substructure: synthesis and activity of the C-8 substituent.
Topics: Animals; Aorta; Benzopyrans; Cromakalim; Epoxy Compounds; In Vitro Techniques; Muscle Contraction; Muscle, Smooth, Vascular; Pinacidil; Portal Vein; Potassium Channels; Rats; Rats, Inbred SHR; Rats, Wistar; Structure-Activity Relationship | 2003 |
Increased superoxide dismutase and Na+, K+-ATPase activities in aortic strips from potassium-adapted rats: implication for altered vascular reactivity.
Topics: Acetylcholine; Adaptation, Physiological; Animals; Aorta, Thoracic; Cromakalim; Isometric Contraction; Male; Muscle Contraction; Muscle, Smooth, Vascular; Nitroprusside; Potassium, Dietary; Rats; Rats, Wistar; Sodium-Potassium-Exchanging ATPase; Superoxide Dismutase; Vasodilator Agents | 2003 |
Correlation between spontaneous electrical, calcium and mechanical activity in detrusor smooth muscle of the guinea-pig bladder.
Topics: Action Potentials; Amides; Animals; Apamin; Boron Compounds; Calcium; Calcium Signaling; Carbachol; Charybdotoxin; Colforsin; Cromakalim; Cyclic GMP; Dose-Response Relationship, Drug; Drug Synergism; Female; Fura-2; Guinea Pigs; Isotonic Contraction; Male; Mechanotransduction, Cellular; Microelectrodes; Muscle Contraction; Muscle, Smooth; Nifedipine; Pyridines; Transducers; Urinary Bladder | 2004 |
1-(2-pyrimidinyl)-piperazine, a buspirone metabolite, modulates bladder function in the anesthetized rat.
Topics: Acetic Acid; Adrenergic alpha-2 Receptor Antagonists; Adrenergic alpha-Antagonists; Anesthesia; Animals; ATP-Binding Cassette Transporters; Benzhydryl Compounds; Buspirone; Cresols; Cromakalim; Dose-Response Relationship, Drug; Female; Imidazoles; Indoles; Isoindoles; KATP Channels; Muscarinic Antagonists; Muscle Contraction; Muscle, Smooth; Phenylpropanolamine; Potassium Channels; Potassium Channels, Inwardly Rectifying; Rats; Rats, Wistar; Tolterodine Tartrate; Urinary Bladder; Urodynamics; Yohimbine | 2004 |
KATP-channel-induced vasodilation is modulated by the Na,K-pump activity in rabbit coronary small arteries.
Topics: Animals; Arteries; ATP-Binding Cassette Transporters; Cardiotonic Agents; Coronary Vessels; Cromakalim; Female; Glyburide; Hypoglycemic Agents; In Vitro Techniques; KATP Channels; Muscle Contraction; Muscle Relaxation; Muscle, Smooth, Vascular; Ouabain; Patch-Clamp Techniques; Pinacidil; Potassium; Potassium Channels; Potassium Channels, Inwardly Rectifying; Rabbits; Sodium-Potassium-Exchanging ATPase; Vasodilation; Vasodilator Agents | 2004 |
Alteration of cyclopiazonic acid-mediated contracture of mouse diaphragm after denervation.
Topics: Action Potentials; Animals; Biological Assay; Boron Compounds; Caffeine; Cromakalim; Crotalid Venoms; Diaphragm; Electric Stimulation; Estrenes; Female; Glyburide; Indoles; Male; Membrane Potentials; Mice; Mice, Inbred ICR; Muscle Contraction; Muscle Denervation; Nicardipine; Phrenic Nerve; Pyrrolidinones; Sarcoplasmic Reticulum | 2005 |
Antispasmodic and blood pressure lowering effects of Valeriana wallichii are mediated through K+ channel activation.
Topics: Animals; Cromakalim; Glyburide; Guinea Pigs; Hypoglycemic Agents; Ileum; In Vitro Techniques; Jejunum; Muscle Contraction; Muscle Relaxation; Muscle, Smooth; Parasympatholytics; Plant Extracts; Plant Roots; Potassium Channels; Rabbits; Rats; Rats, Sprague-Dawley; Valerian; Vascular Resistance | 2005 |
Sulphonylurea receptors differently modulate ICC pacemaker Ca2+ activity and smooth muscle contractility.
Topics: Animals; ATP-Binding Cassette Transporters; Base Sequence; Calcium; Calcium Channels; Cells, Cultured; Cromakalim; Diazoxide; Ileum; Immunohistochemistry; KATP Channels; Mice; Mice, Inbred BALB C; Multidrug Resistance-Associated Proteins; Muscle Contraction; Muscle, Smooth; Potassium Channels, Inwardly Rectifying; Receptors, Drug; Reverse Transcriptase Polymerase Chain Reaction; Sulfonylurea Receptors | 2005 |
Pharmacological characterization of urinary bladder smooth muscle contractility following partial bladder outlet obstruction in pigs.
Topics: Adenosine Triphosphate; Amides; Animals; Benzophenones; Carbachol; Cholinergic Agonists; Cromakalim; Cyclic S-Oxides; Diazoxide; Dose-Response Relationship, Drug; Electric Stimulation; Female; Guanidines; Histamine; Hypertrophy; In Vitro Techniques; Muscle Contraction; Muscle, Smooth; Potassium Channels; Potassium Chloride; Pyridines; Quinolones; Serotonin; Serotonin Agents; Swine; Urinary Bladder; Urinary Bladder Neck Obstruction; Vasodilator Agents | 2006 |
Design, synthesis, and pharmacological evaluation of R/S-3,4-dihydro-2,2-dimethyl- 6-halo-4-(phenylaminocarbonylamino)-2H-1-benzopyrans: toward tissue-selective pancreatic beta-cell KATP channel openers structurally related to (+/-)-cromakalim.
Topics: Adenosine Triphosphate; Animals; Aorta, Thoracic; Benzopyrans; Cromakalim; In Vitro Techniques; Insulin; Insulin Secretion; Insulin-Secreting Cells; Ion Channel Gating; Muscle Contraction; Muscle, Smooth, Vascular; Patch-Clamp Techniques; Phenylurea Compounds; Potassium Channels; Rats; Rats, Wistar; Stereoisomerism; Structure-Activity Relationship | 2006 |
Effect of KATP channel openers on myogenic and neurogenic responses in goat urinary bladder.
Topics: Acetylcholine; Animals; Atropine; Cholinergic Agents; Cromakalim; Dose-Response Relationship, Drug; Electric Stimulation; Female; Glyburide; Goats; In Vitro Techniques; Male; Muscarinic Antagonists; Muscle Contraction; Muscle, Smooth; Pinacidil; Potassium Channel Blockers; Potassium Channels; Urinary Bladder | 2007 |
Store-refilling involves both L-type calcium channels and reverse-mode sodium-calcium exchange in airway smooth muscle.
Topics: Acetylcholine; Analysis of Variance; Animals; Blotting, Western; Calcium Channels, L-Type; Calcium Signaling; Cattle; Cromakalim; Muscle Contraction; Muscle, Smooth; Nifedipine; Sodium-Calcium Exchanger; Thiourea; Trachea | 2007 |
Inhibitory effects of different ATP-sensitive potassium channel openers on electrically generated and carbachol-induced contractions of porcine and human detrusor muscle.
Topics: Aged; Amides; Animals; Benzophenones; Carbachol; Cromakalim; Electric Stimulation; Female; Humans; In Vitro Techniques; Male; Minoxidil; Muscle Contraction; Muscle, Smooth; Pinacidil; Potassium Channels; Swine; Urinary Bladder | 2008 |
Potassium channel inhibitors attenuate neuromodulatory effects of atrial natriuretic factor in the rabbit isolated vas deferens.
Topics: 4-Aminopyridine; Adenosine Triphosphate; Animals; Atrial Natriuretic Factor; Benzopyrans; Charybdotoxin; Cromakalim; Glyburide; In Vitro Techniques; Male; Muscle Contraction; Norepinephrine; Potassium Channel Blockers; Potassium Channels; Prazosin; Pyrroles; Rabbits; Receptors, Adrenergic; Scorpion Venoms; Synaptic Transmission; Tetraethylammonium; Tetraethylammonium Compounds; Vas Deferens | 1994 |
Pharmacologic profiles of YM934, a novel potassium channel opener.
Topics: Anesthesia; Animals; Aorta; Benzopyrans; Benzoxazines; Cromakalim; Cyclic N-Oxides; Dogs; Female; Hemodynamics; In Vitro Techniques; Male; Muscle Contraction; Muscle Relaxation; Muscle, Smooth, Vascular; Nifedipine; Oxazines; Portal Vein; Potassium Channels; Pyrroles; Rabbits; Rats; Rats, Wistar; Vascular Resistance; Vasodilation | 1994 |
Vasodilating actions of cromakalim in resting and contracting states of carotid arteries from spontaneously hypertensive rats.
Topics: Animals; Benzopyrans; Carotid Arteries; Charybdotoxin; Cromakalim; Drug Interactions; Glyburide; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth, Vascular; Norepinephrine; Potassium; Pyrroles; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Scorpion Venoms; Species Specificity; Vasodilator Agents | 1994 |
Functional evidence for a glibenclamide-sensitive K+ channel in rat ileal smooth muscle.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Animals; Benzopyrans; Calcitonin Gene-Related Peptide; Carbachol; Cromakalim; Glyburide; Ileum; Male; Muscle Contraction; Muscle, Smooth; Potassium Channels; Pyrroles; Rats; Rats, Wistar | 1994 |
Propagation of impulses in the guinea-pig ureter and its blockade by calcitonin gene-related peptide (CGRP).
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Action Potentials; Animals; Benzopyrans; Calcitonin Gene-Related Peptide; Cromakalim; Electric Stimulation; Glyburide; Guinea Pigs; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth; Nifedipine; Pyrroles; Tetrodotoxin; Ureter | 1995 |
Response of guinea pig smooth and striated urethral sphincter to cromakalim, prazosin, nifedipine, nitroprusside, and electrical stimulation.
Topics: Amino Acid Oxidoreductases; Animals; Antihypertensive Agents; Benzopyrans; Calcium; Calmodulin-Binding Proteins; Cromakalim; Decamethonium Compounds; Electric Stimulation; Guinea Pigs; Hexamethonium; Histocytochemistry; Male; Muscle Contraction; Muscle Relaxation; Muscle, Skeletal; Muscle, Smooth; Nifedipine; Nitric Oxide Synthase; Nitroprusside; Prazosin; Pyrroles; Urethra | 1995 |
Inhibition by cromakalim, pinacidil, terbutaline, theophylline and verapamil of non-cholinergic nerve-mediated contractions of guinea-pig isolated bronchi.
Topics: Animals; Benzopyrans; Bronchi; Bronchodilator Agents; Cromakalim; Dose-Response Relationship, Drug; Guanidines; Guinea Pigs; Muscle Contraction; Muscle, Smooth; Neuromuscular Junction; Pinacidil; Potassium Channels; Pyrroles; Substance P; Synaptic Transmission; Terbutaline; Theophylline; Verapamil | 1994 |
The effects of glibenclamide on tetanic force and intracellular calcium in normal and fatigued mouse skeletal muscle.
Topics: Acidosis; Adenosine Triphosphate; Animals; Benzopyrans; Calcium; Cromakalim; Electric Stimulation; Glyburide; Intracellular Membranes; Male; Mice; Muscle Contraction; Muscle Fatigue; Muscle, Skeletal; Potassium Channel Blockers; Potassium Channels; Pyrroles; Reference Values | 1995 |
Pharmacological natures of caffeine-induced endothelium-dependent and -independent contraction in canine mesenteric artery.
Topics: Adenylyl Cyclases; Animals; Benzopyrans; Caffeine; Calcium; Calcium Channel Blockers; Colforsin; Cromakalim; Dogs; Edetic Acid; Egtazic Acid; Endothelium, Vascular; Female; In Vitro Techniques; Magnesium; Male; Mesenteric Arteries; Muscle Contraction; Muscle, Smooth, Vascular; Nifedipine; Nitroglycerin; Potassium Channels; Pyrroles; Vasodilator Agents | 1995 |
Functional study on the effects of nifedipine, cromakalim, and the absence of extracellular Ca2+ on alpha 1-adrenoceptor-mediated excitation-contraction coupling in isolated rat portal vein: comparison with depolarization-mediated excitation-contraction c
Topics: Animals; Benzopyrans; Calcium; Calcium Channel Blockers; Cromakalim; In Vitro Techniques; Kinetics; Male; Muscle Contraction; Muscle, Smooth, Vascular; Nifedipine; Parasympatholytics; Phenylephrine; Portal Vein; Potassium Channels; Potassium Chloride; Pyrroles; Rats; Rats, Wistar; Receptors, Adrenergic, alpha | 1993 |
Cromakalim inhibits multiple mechanisms of smooth muscle activation with similar stereoselectivity.
Topics: Animals; Aorta, Thoracic; Benzopyrans; Calcium; Cromakalim; Glyburide; In Vitro Techniques; Muscle Contraction; Muscle Tonus; Muscle, Smooth, Vascular; Neuromuscular Depolarizing Agents; Norepinephrine; Potassium Chloride; Pyrroles; Rabbits; Stereoisomerism; Vasodilator Agents | 1993 |
Distinct pathways to refill ACh-sensitive internal Ca2+ stores in canine airway smooth muscle.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Acetylcholine; Animals; Benzopyrans; Calcium; Cromakalim; Dogs; Female; Indoles; Male; Muscle Contraction; Muscle, Smooth; Nifedipine; Pyrroles; Trachea | 1993 |
Effects of cromakalim on bradykinin-, histamine- and substance P-induced airway microvascular leakage in the guinea-pig.
Topics: Animals; Benzopyrans; Bradykinin; Bronchi; Capillary Permeability; Cromakalim; Electric Stimulation; Evans Blue; Female; Guinea Pigs; Histamine; In Vitro Techniques; Injections, Intravenous; Lung; Male; Muscle Contraction; Muscle, Smooth; Pyrroles; Respiratory System; Substance P; Trachea | 1993 |
A simple method for measurement of ureteric peristaltic function in vivo and the effects of drugs acting on ion channels applied from the ureter lumen in anesthetized rats.
Topics: 4-Aminopyridine; Anesthesia; Animals; Benzopyrans; Cromakalim; Glyburide; Ion Channels; Lidocaine; Male; Muscle Contraction; Muscle, Smooth; Nifedipine; Pyrroles; Rats; Rats, Sprague-Dawley; Ureter; Vasodilator Agents | 1993 |
Mechanical and electrophysiological effects of cromakalim on the human urinary bladder.
Topics: Adult; Benzopyrans; Cromakalim; Electrophysiology; Female; Humans; Male; Membrane Potentials; Middle Aged; Muscle Contraction; Muscle, Smooth; Parasympatholytics; Potassium Channels; Pyrroles; Stress, Mechanical; Urinary Bladder | 1994 |
Cardioprotective profile of the cardiac-selective ATP-sensitive potassium channel opener BMS-180448.
Topics: Adenosine Triphosphate; Animals; Anti-Arrhythmia Agents; Aorta; Benzopyrans; Cromakalim; Decanoic Acids; Dogs; Female; Glyburide; Guanidines; Guinea Pigs; Heart; Heart Ventricles; Hydroxy Acids; In Vitro Techniques; Injections, Intravenous; Injections, Subcutaneous; Male; Muscle Contraction; Muscle Relaxation; Muscle, Smooth, Vascular; Myocardial Ischemia; Potassium Channels; Pyrroles; Rats; Rats, Sprague-Dawley; Vasodilator Agents | 1995 |
The inhibitory mechanisms of nicorandil in isolated rat urinary bladder and femoral artery.
Topics: Acetylcholine; Animals; Benzopyrans; Cromakalim; Cyclic GMP; Electric Stimulation; Femoral Artery; Guanylate Cyclase; Male; Muscle Contraction; Muscle Relaxation; Muscle, Smooth; Muscle, Smooth, Vascular; Niacinamide; Nicorandil; Nitroglycerin; Potassium Channels; Potassium Chloride; Pyrroles; Rats; Rats, Wistar; Urinary Bladder; Vasodilator Agents | 1995 |
Effects of potassium channel activators on isolated cerebral arteries of large and small diameter in the cat.
Topics: Animals; Benzopyrans; Cats; Cerebral Arteries; Cromakalim; Dihydropyridines; Dose-Response Relationship, Drug; Female; Glyburide; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth, Vascular; Potassium Channels; Pyrroles; Uridine Triphosphate; Vasodilator Agents | 1995 |
Differential effects of pinacidil and cromakalim on vascular relaxation and sympathetic neurotransmission.
Topics: Animals; Benzopyrans; Cattle; Cromakalim; Dogs; Electric Stimulation; Female; Guanidines; In Vitro Techniques; Male; Muscle Contraction; Muscle Relaxation; Muscle, Smooth, Vascular; Norepinephrine; Pinacidil; Potassium Chloride; Pyrroles; Sympathetic Nervous System; Synaptic Transmission; Vasodilator Agents | 1994 |
Multiple mechanisms in the smooth muscle relaxant action of calcitonin gene-related peptide (CGRP) in the guinea-pig ureter.
Topics: Action Potentials; Animals; Arginine; Benzopyrans; Calcitonin Gene-Related Peptide; Colforsin; Cromakalim; Dose-Response Relationship, Drug; Electric Stimulation; Glyburide; Guinea Pigs; In Vitro Techniques; Isoproterenol; Male; Muscle Contraction; Muscle, Smooth; Nitroarginine; Parasympatholytics; Pyrroles; Ureter | 1994 |
The effects of a novel vasodilator, LP-805, on cytosolic Ca2+ concentrations and on tension in rabbit isolated femoral arteries.
Topics: Animals; Arginine; Benzopyrans; Calcium; Cromakalim; Cytosol; Endothelium, Vascular; Femoral Artery; Fura-2; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth, Vascular; Nitric Oxide; Nitroarginine; Norepinephrine; Potassium; Pyrazoles; Pyrimidines; Pyrroles; Rabbits; Vasodilator Agents | 1994 |
Mechanical and electrophysiological effects of cromakalim on the human urinary bladder.
Topics: Animals; Benzopyrans; Cromakalim; Female; Guinea Pigs; Humans; In Vitro Techniques; Male; Middle Aged; Muscle Contraction; Muscle, Smooth; Parasympatholytics; Patch-Clamp Techniques; Potassium Channels; Pyrroles; Rats; Urinary Bladder | 1994 |
Mechanisms of vasorelaxation induced by N-allylsecoboldine in rat thoracic aorta.
Topics: Adrenergic alpha-1 Receptor Antagonists; Animals; Aorta, Thoracic; Aporphines; Benzopyrans; Calcium Channel Blockers; Cromakalim; Cyclic AMP; Cyclic GMP; Female; Glyburide; In Vitro Techniques; Male; Muscle Contraction; Muscle Relaxation; Muscle, Smooth, Vascular; Phosphatidylinositols; Potassium; Pyrroles; Rats; Rats, Wistar; Vasodilator Agents; Verapamil | 1994 |
Effect of cromakalim and glibenclamide on spontaneous and evoked motility of the guinea-pig isolated renal pelvis and ureter.
Topics: Action Potentials; Animals; Benzopyrans; Cromakalim; Electrophysiology; Glyburide; Guinea Pigs; In Vitro Techniques; Kidney Pelvis; Male; Membrane Potentials; Muscle Contraction; Potassium Channels; Pyrroles; Ureter | 1994 |
The effects of racemic cromakalim, BRL 38226 and levcromakalim on the membrane potential of the rat aorta and of BRL 38226 on the contractile activity of the rat aorta and portal vein.
Topics: Animals; Aorta, Thoracic; Benzopyrans; Cromakalim; Glyburide; In Vitro Techniques; Isoproterenol; Membrane Potentials; Muscle Contraction; Muscle, Smooth, Vascular; Portal Vein; Potassium Channels; Potassium Chloride; Pyrroles; Rats; Rats, Wistar; Stereoisomerism; Vasoconstrictor Agents | 1994 |
Levcromakalim-induced modulation of membrane potassium currents, intracellular calcium and mechanical activity in rat mesenteric artery.
Topics: Animals; Arterioles; Benzopyrans; Calcium; Cell Membrane; Cromakalim; Electrophysiology; In Vitro Techniques; Male; Mesenteric Arteries; Muscle Contraction; Muscle, Smooth, Vascular; Nifedipine; Norepinephrine; Potassium Channels; Potassium Chloride; Pyrroles; Rats; Rats, Sprague-Dawley; Vasodilator Agents | 1994 |
Beta-adrenoceptor subtypes and the opening of plasmalemmal K(+)-channels in trachealis muscle: electrophysiological and mechanical studies in guinea-pig tissue.
Topics: Adrenergic beta-Agonists; Adrenergic beta-Antagonists; Albuterol; Animals; Benzopyrans; Cell Membrane; Cromakalim; Electrophysiology; Female; Guinea Pigs; Heart; Imidazoles; In Vitro Techniques; Isoproterenol; Male; Muscle Contraction; Muscle, Smooth; Myocardium; Norepinephrine; Potassium Channels; Procaterol; Propanolamines; Pyrroles; Receptors, Adrenergic, beta; Rubidium Radioisotopes; Salmeterol Xinafoate; Trachea | 1993 |
Cromakalim does not protect against skeletal muscle fatigue in an anaesthetized rat model of acute hindlimb ischaemia.
Topics: Animals; Benzopyrans; Blood Pressure; Cromakalim; Disease Models, Animal; Dose-Response Relationship, Drug; Electric Stimulation; Heart Rate; Hindlimb; Ischemia; Male; Muscle Contraction; Muscles; Pyrroles; Rats; Rats, Sprague-Dawley; Regional Blood Flow; Vasodilator Agents | 1993 |
Effects of K-channel openers on the contractility and electrical activity of antral circular muscle in guinea-pig stomach.
Topics: Action Potentials; Animals; Benzopyrans; Cromakalim; Glyburide; Guinea Pigs; In Vitro Techniques; Ion Channel Gating; Muscle Contraction; Muscle, Smooth; Niacinamide; Nicorandil; Potassium Channels; Pyrroles; Stomach | 1993 |
Partial inhibition by epithelium of tracheal smooth muscle relaxation induced by the potassium channel activator, BRL 38227.
Topics: Aminophylline; Animals; Benzopyrans; Biotransformation; Bronchodilator Agents; Carbachol; Cromakalim; Epithelium; In Vitro Techniques; Male; Muscle Contraction; Muscle Relaxation; Muscle, Smooth; Potassium Channels; Pyrroles; Rats; Rats, Sprague-Dawley; Trachea | 1993 |
Effects of three K+ channel openers on airways and pulmonary circulation in the isolated guinea-pig lung.
Topics: Animals; Benzopyrans; Bronchoconstriction; Cromakalim; Dose-Response Relationship, Drug; Guanidines; Guinea Pigs; In Vitro Techniques; Lung; Male; Muscle Contraction; Muscle, Smooth, Vascular; Picolines; Pinacidil; Potassium; Potassium Channels; Pulmonary Circulation; Pyrans; Pyrroles | 1993 |
ATP-sensitive potassium channels and skeletal muscle function in vitro.
Topics: Animals; Benzopyrans; Cromakalim; Electric Stimulation; Energy Metabolism; Gallamine Triethiodide; Glyburide; Guanidines; In Vitro Techniques; Ischemia; Male; Muscle Contraction; Muscles; Pinacidil; Potassium Channels; Pyridines; Pyrroles; Rats; Rats, Sprague-Dawley | 1993 |
Vasodilator action of cromakalim on human mesenteric artery.
Topics: Aged; Aged, 80 and over; Benzopyrans; Cromakalim; Humans; In Vitro Techniques; Mesenteric Arteries; Middle Aged; Muscle Contraction; Muscle Relaxation; Muscle, Smooth, Vascular; Norepinephrine; Potassium Chloride; Pyrroles; Vasodilation; Vasodilator Agents | 1993 |
Effects of the novel potassium channel opener, UR-8225, on contractile responses in rat isolated smooth muscle.
Topics: Animals; Antihypertensive Agents; Benzopyrans; Calcium; Cromakalim; Female; In Vitro Techniques; Ion Channel Gating; Male; Membrane Potentials; Muscle Contraction; Muscle, Smooth, Vascular; Naphthalenes; Norepinephrine; Portal Vein; Potassium Channels; Potassium Chloride; Pyridones; Pyrroles; Rats; Rats, Sprague-Dawley; Rubidium; Rubidium Radioisotopes; Vasodilator Agents | 1993 |
Effects of KC 399, a novel ATP-sensitive K+ channel opener, on electrical and mechanical responses in dog tracheal smooth muscle.
Topics: Adenosine Triphosphate; Animals; Benzopyrans; Carbachol; Cromakalim; Cyclic AMP; Cyclic GMP; Dogs; Female; Glyburide; In Vitro Techniques; Inositol 1,4,5-Trisphosphate; Male; Membrane Potentials; Muscle Contraction; Muscle, Smooth; Potassium Channels; Pyrroles; Trachea | 1994 |
Actions of potassium channel openers in rat detrusor urinae.
Topics: Animals; Benzopyrans; Cromakalim; Guanidines; In Vitro Techniques; Muscle Contraction; Muscle, Smooth; Picolines; Potassium Channels; Pyrans; Pyrroles; Rats; Rats, Sprague-Dawley; Urinary Bladder | 1993 |
Effects of cromakalim on the electrical slow wave in the circular muscle of guinea-pig gastric antrum.
Topics: Animals; Benzopyrans; Cromakalim; Electrophysiology; Female; Glyburide; Guinea Pigs; In Vitro Techniques; Male; Membrane Potentials; Muscle Contraction; Muscle, Smooth; Parasympatholytics; Potassium; Pyloric Antrum; Pyrroles; Sodium | 1993 |
The inhibitory effects of Ro 31-6930 and BRL 38227 on cholinergically-mediated bronchoconstriction in the guinea-pig.
Topics: Acetylcholine; Animals; Benzopyrans; Bronchoconstriction; Bronchodilator Agents; Cromakalim; Electric Stimulation; Guinea Pigs; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth; Potassium Channels; Pyridines; Pyrroles; Trachea; Vagus Nerve | 1993 |
Effect of cromakalim on KCl-, noradrenaline- and angiotensin II-induced contractions in the rat pulmonary artery.
Topics: Angiotensin II; Animals; Benzopyrans; Bronchodilator Agents; Cromakalim; Glyburide; In Vitro Techniques; Isometric Contraction; Male; Muscle Contraction; Muscle, Smooth, Vascular; Norepinephrine; Phentolamine; Potassium Chloride; Pulmonary Artery; Pyrroles; Rats; Rats, Wistar; Tetraethylammonium Compounds | 1993 |
Inhibitory effect of cromakalim in human detrusor muscle is mediated by glibenclamide-sensitive potassium channels.
Topics: Benzopyrans; Cromakalim; Depression, Chemical; Dose-Response Relationship, Drug; Glyburide; Humans; In Vitro Techniques; Male; Muscle Contraction; Potassium Channels; Pyrroles; Urinary Bladder | 1993 |
The effect of cromakalim on the electrical properties of and [86Rb+] efflux from normal and hypertrophied rat bladder.
Topics: Action Potentials; Animals; Benzopyrans; Calcium Channel Blockers; Cromakalim; Electrophysiology; Female; Hypertrophy; In Vitro Techniques; Membrane Potentials; Microelectrodes; Muscle Contraction; Muscle, Smooth; Nifedipine; Parasympatholytics; Pyrroles; Rats; Rats, Sprague-Dawley; Rubidium; Rubidium Radioisotopes; Urinary Bladder | 1993 |
The individual enantiomers of cis-cromakalim possess K+ channel opening activity.
Topics: Anesthesia; Animals; Aorta, Thoracic; Benzopyrans; Binding, Competitive; Blood Pressure; Cromakalim; Endothelium, Vascular; Guanidines; Heart Rate; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth, Vascular; Norepinephrine; Portal Vein; Potassium Channels; Pyridines; Pyrroles; Rats; Rats, Wistar; Rubidium Radioisotopes; Stereoisomerism; Vasodilation; Vasodilator Agents | 1993 |
Relaxation of subarachnoid hemorrhage-induced spasm of rabbit basilar artery by the K+ channel activator cromakalim.
Topics: Animals; Basilar Artery; Benzopyrans; Cromakalim; Dose-Response Relationship, Drug; In Vitro Techniques; Ischemic Attack, Transient; Male; Muscle Contraction; Muscle Relaxation; Muscle, Smooth, Vascular; Nitroprusside; Potassium; Potassium Channels; Pyrroles; Rabbits; Subarachnoid Hemorrhage; Time Factors; Vasodilator Agents | 1996 |
Effects of potassium channel modulators cromakalim, tetraethylammonium and glibenclamide on the contractility of the isolated human ureter.
Topics: Benzopyrans; Cromakalim; Glyburide; Humans; In Vitro Techniques; Muscle Contraction; Muscle, Smooth; Potassium Channels; Potassium Chloride; Pyrroles; Tetraethylammonium; Tetraethylammonium Compounds; Ureter | 1996 |
The effects of pharmacological modulation of KATP on the guinea-pig isolated diaphragm.
Topics: Adenosine Triphosphate; Animals; Benzopyrans; Cromakalim; Diaphragm; Electrophysiology; Glyburide; Guanidines; Guinea Pigs; Indoles; Male; Membrane Potentials; Muscle Contraction; Muscle Tonus; Phentolamine; Pinacidil; Potassium Channels; Pyrroles | 1996 |
Effects of chronic oral administration of levcromakalim on in vitro contractile responses of arterial smooth muscle.
Topics: Animals; Aorta; Benzopyrans; Calcium Channel Blockers; Cromakalim; Cyclic GMP; Dose-Response Relationship, Drug; Drug Tolerance; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth, Vascular; Nitroprusside; Potassium Channels; Pyrroles; Rats; Rats, Inbred SHR; Rats, Wistar; Vasodilator Agents; Verapamil | 1996 |
Comparative effects of intravesical versus extravesical administration of ZD6169 and cromakalim on the response of the in vitro rat whole bladder to field stimulation.
Topics: Amides; Animals; Benzophenones; Benzopyrans; Cromakalim; Electric Stimulation; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth; Potassium Channels; Pyrroles; Rats; Rats, Sprague-Dawley; Urinary Bladder | 1996 |
Pharmacodynamic behaviour of isolated resistance vessels obtained from hypertensive-diabetic rats.
Topics: Animals; Benzopyrans; Blood Glucose; Calcium Channels; Calcium Chloride; Cromakalim; Glyburide; Hypertension; In Vitro Techniques; Male; Mesenteric Arteries; Methacholine Chloride; Methoxamine; Muscle Contraction; Muscle, Smooth; Nifedipine; Nitroprusside; Norepinephrine; Obesity; Potassium Channels; Potassium Chloride; Pyrroles; Rats; Rats, Zucker; Serotonin; Tunica Media; Vascular Resistance; Vasoconstrictor Agents; Vasodilator Agents | 1996 |
Effects of SCA40 on human bronchi and on guinea pig main bronchi in vitro. Comparison with cromakalim.
Topics: Acetylcholine; Animals; Benzopyrans; Bronchi; Bronchodilator Agents; Capsaicin; Charybdotoxin; Cromakalim; Electric Stimulation; Female; Glyburide; Guinea Pigs; Humans; Imidazoles; In Vitro Techniques; Isoproterenol; Male; Muscle Contraction; Muscle Relaxation; Muscle, Smooth; Neurokinin A; Nitroprusside; Osmolar Concentration; Parasympatholytics; Potassium Channel Blockers; Potassium Channels; Pyrazines; Pyrroles; Tetraethylammonium; Tetraethylammonium Compounds | 1996 |
Possible mechanism of the potent vasoconstrictor responses to ryanodine in dog cerebral arteries.
Topics: Animals; Benzopyrans; Caffeine; Calcium; Calcium Channel Blockers; Cerebral Arteries; Cromakalim; Dogs; Female; In Vitro Techniques; Isometric Contraction; Male; Muscle Contraction; Muscle Tonus; Muscle, Smooth, Vascular; Nifedipine; Phosphodiesterase Inhibitors; Potassium; Pyrroles; Ryanodine; Vasoconstrictor Agents; Vasodilator Agents | 1996 |
Potassium channel modulation: a new drug principle for regulation of smooth muscle contractility. Studies on isolated airways and arteries.
Topics: Animals; Arteries; Asthma; Benzopyrans; Bronchi; Cardiovascular Diseases; Cromakalim; Female; Guinea Pigs; Humans; Male; Membrane Potentials; Muscle Contraction; Muscle, Smooth; Muscle, Smooth, Vascular; Potassium Channels; Pyrroles; Sulfonylurea Compounds; Synaptic Transmission; Trachea; Vasodilator Agents | 1996 |
Relaxant effect of levcromakalim in isolated human small subcutaneous arteries.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Adenosine Triphosphate; Adolescent; Adult; Arteries; Benzopyrans; Cromakalim; Dose-Response Relationship, Drug; Drug Interactions; Female; Glyburide; Humans; In Vitro Techniques; Methacholine Chloride; Middle Aged; Muscle Contraction; Muscle Relaxation; Muscle, Smooth, Vascular; Potassium Channels; Prostaglandin Endoperoxides, Synthetic; Pyrroles; Skin; Thromboxane A2; Vasoconstrictor Agents | 1995 |
Involvement of K+ channels in the relaxant effect of vasoactive intestinal peptide and atrial natriuretic peptide in isolated guinea-pig trachea.
Topics: Adenosine Triphosphate; Animals; Atrial Natriuretic Factor; Benzopyrans; Calcium Channel Blockers; Cromakalim; Guinea Pigs; In Vitro Techniques; Isradipine; Muscle Contraction; Muscle Relaxation; Muscle, Smooth; Potassium Channels; Pyrroles; Trachea; Vasoactive Intestinal Peptide | 1997 |
Novel effects of guanidine on the neuromuscular junction.
Topics: 4-Aminopyridine; Animals; Benzopyrans; Calcium; Chickens; Cromakalim; Electric Stimulation; Electromyography; Evoked Potentials, Motor; Guanidine; Guanidines; In Vitro Techniques; Male; Mice; Muscle Contraction; Neuromuscular Junction; Potassium Channels; Pyrroles | 1997 |
Effects of putative K+ channel blockers on beta-adrenoceptor-mediated vasorelaxation of rat mesenteric artery.
Topics: Adenosine Triphosphate; Adrenergic beta-Agonists; Animals; Barium; Benzopyrans; Calcium; Charybdotoxin; Colforsin; Cromakalim; Cyclic AMP; Dose-Response Relationship, Drug; Fenoterol; Glyburide; Isoproterenol; Male; Mesenteric Arteries; Muscle Contraction; Muscle Relaxation; Muscle, Smooth, Vascular; Phenylephrine; Potassium Channel Blockers; Pyrroles; Rats; Rats, Sprague-Dawley; Vasoconstrictor Agents; Vasodilator Agents | 1997 |
The effect of cromakalim on intracellular [Ca2+] in isolated rat skeletal muscle during fatigue and metabolic blockade.
Topics: Adenosine Triphosphate; Animals; Benzopyrans; Calcium; Cromakalim; Cyanides; In Vitro Techniques; Intracellular Fluid; Iodoacetates; Iodoacetic Acid; Male; Muscle Contraction; Muscle Fatigue; Muscle, Skeletal; Osmolar Concentration; Potassium Channels; Pyrroles; Rats; Rats, Wistar | 1997 |
Effects of JTV-506, a new K+ channel activator, on airway smooth muscle contraction and systemic blood pressure.
Topics: Animals; Benzopyrans; Blood Pressure; Bronchodilator Agents; Chromans; Cromakalim; Guinea Pigs; Histamine; In Vitro Techniques; Isometric Contraction; Male; Muscle Contraction; Muscle, Smooth; Potassium Channels; Pyrroles; Trachea | 1997 |
Capacitative Ca2+ entry associated with alpha1-adrenoceptors in rat aorta.
Topics: Animals; Aorta; Benzopyrans; Calcium; Calcium Channel Blockers; Calcium Channels; Cromakalim; Glyburide; In Vitro Techniques; Male; Muscle Contraction; Muscle Tonus; Nimodipine; Norepinephrine; Potassium Channel Blockers; Potassium Channels; Pyrroles; Rats; Rats, Wistar; Receptors, Adrenergic, alpha-1; Tetraethylammonium Compounds | 1997 |
Heterogeneity in the vasorelaxing effect of nicorandil on dog epicardial coronary arteries: comparison with other NO donors.
Topics: Animals; Atrial Natriuretic Factor; Benzopyrans; Coronary Vessels; Cromakalim; Cyclic GMP; Dogs; Female; Glyburide; In Vitro Techniques; Male; Methylene Blue; Molsidomine; Muscle Contraction; Muscle Relaxation; Muscle, Smooth, Vascular; Niacinamide; Nicorandil; Nitric Oxide; Nitroglycerin; Nitroprusside; Oxyhemoglobins; Pyrroles; Vasodilator Agents | 1997 |
Influence of cytochrome P-450 inhibitors on endothelium-dependent nitro-L-arginine-resistant relaxation and cromakalim-induced relaxation in rat mesenteric arteries.
Topics: Acetylcholine; Animals; Benzopyrans; Biological Factors; Cromakalim; Cytochrome P-450 Enzyme Inhibitors; Fatty Acids, Unsaturated; Female; In Vitro Techniques; Mesenteric Arteries; Miconazole; Muscle Contraction; Muscle Relaxation; Muscle, Smooth, Vascular; Nitroarginine; Norepinephrine; Proadifen; Pyrroles; Rats; Rats, Wistar; Triazoles; Vasodilator Agents | 1997 |
Possible involvement of ATP-dependent K-channel related mechanisms in the antihypertensive and cough suppressant effects of the novel ACE inhibitor (2S, 3aS, 7aS)-1-(N2-nicotinoyl-L-lysyl-gamma-D-glutamyl)octahydro-1H- indole-2-carboxylic acid.
Topics: Adenosine Triphosphate; Angiotensin-Converting Enzyme Inhibitors; Animals; Antihypertensive Agents; Antitussive Agents; Aorta, Thoracic; Benzopyrans; Blood Pressure; Cromakalim; Dipeptides; Glyburide; Guinea Pigs; In Vitro Techniques; Indoles; Male; Muscle Contraction; Muscle Relaxation; Muscle, Smooth, Vascular; Potassium Channels; Pyrroles; Rats; Rats, Sprague-Dawley; Rats, Wistar | 1997 |
The comparison of the responsiveness of human isolated internal mammary and gastroepiploic arteries to levcromakalim: an alternative approach to the management of graft spasm.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Arteries; Benzopyrans; Coronary Artery Bypass; Cromakalim; Endothelin-1; Female; Glyburide; Humans; In Vitro Techniques; Indomethacin; Male; Mammary Arteries; Middle Aged; Muscle Contraction; Muscle Relaxation; Muscle, Smooth, Vascular; Nitroarginine; Norepinephrine; Omentum; Potassium; Potassium Channel Blockers; Potassium Channels; Prostaglandin Endoperoxides, Synthetic; Pyrroles; Stomach; Thromboxane A2; Vasoconstrictor Agents; Vasodilator Agents | 1997 |
Endothelin impairs ATP-sensitive K+ channel function after brain injury.
Topics: Animals; Animals, Newborn; Arterioles; Brain Injuries; Calcitonin Gene-Related Peptide; Cerebral Arteries; Cromakalim; Endothelin-1; Female; Male; Muscle Contraction; Muscle, Smooth, Vascular; Nitroprusside; Penicillamine; Pia Mater; Potassium Channels; S-Nitroso-N-Acetylpenicillamine; Swine | 1997 |
Cardiovascular pharmacology of SKP-450, a new potassium channel activator, and its major metabolites SKP-818 and SKP-310.
Topics: Animals; Antihypertensive Agents; Aorta, Thoracic; Benzopyrans; Coronary Circulation; Cromakalim; Dogs; Dose-Response Relationship, Drug; Hemodynamics; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth, Vascular; Norepinephrine; Potassium Channels; Pyrroles; Pyrrolidinones; Rats; Rats, Sprague-Dawley; Structure-Activity Relationship; Vasodilation; Vasodilator Agents | 1998 |
Differential sensitivity to ATP-sensitive potassium channel openers of norepinephrine-induced contraction of guinea pig and rat aorta.
Topics: Adenosine Triphosphate; Animals; Aorta, Thoracic; Cromakalim; Diltiazem; Dose-Response Relationship, Drug; Female; Glyburide; Guinea Pigs; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth, Vascular; Norepinephrine; Oxadiazoles; Piperidines; Potassium Channels; Rats; Rats, Wistar; Vasoconstrictor Agents; Vasodilation | 1998 |
Levcromakalim decreases vascular tone, cytoplasmic Ca2+ and Ca2+ sensitivity in canine basilar artery.
Topics: Animals; Basilar Artery; Calcium; Calcium Channel Blockers; Cromakalim; Cytoplasm; Dogs; Dose-Response Relationship, Drug; Female; Glyburide; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth, Vascular; Nicardipine; Peptides; Potassium Channel Blockers; Potassium Channels; Serotonin; Tetraethylammonium; Vasoconstriction | 1998 |
Pharmacological characteristics of MJ-451, a new benzopyran- derived ATP-sensitive potassium channel opener, in guinea pig isolated trachea.
Topics: Animals; Benzopyrans; Carbachol; Cromakalim; Drug Interactions; Female; Guinea Pigs; Histamine; Male; Muscle Contraction; Muscle Relaxation; Muscle, Smooth; Parasympatholytics; Parasympathomimetics; Potassium Channels; Potassium Chloride; Pyrrolidinones; Trachea | 1998 |
ATP-sensitive K+ current and its modulation by substance P in gastric myocytes isolated from guinea pig.
Topics: Action Potentials; Adenosine Triphosphate; Animals; Barium; Cesium; Cromakalim; Female; Glyburide; Guinea Pigs; Hypoglycemic Agents; Male; Membrane Potentials; Muscle Contraction; Muscle, Smooth; Patch-Clamp Techniques; Potassium; Potassium Channels; Pyloric Antrum; Substance P; Tetraethylammonium; Vasodilator Agents | 1998 |
Effect of calcium antagonists on the response to noradrenaline in the whole and bisected rat vas deferens.
Topics: Animals; Calcium Channel Blockers; Cromakalim; Diltiazem; Flunarizine; Male; Muscle Contraction; Muscle, Smooth; Nifedipine; Norepinephrine; Organ Culture Techniques; Papaverine; Rats; Rats, Wistar; Vas Deferens | 1998 |
Effect of age on the vasorelaxation elicited by cromakalim. Role of K+ channels and cyclic GMP.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Aging; Animals; Aorta, Thoracic; Cromakalim; Cyclic GMP; Endothelium, Vascular; Glyburide; Hypoglycemic Agents; In Vitro Techniques; Male; Muscle Contraction; Potassium Channels; Rabbits; Vasodilation; Vasodilator Agents | 1998 |
Differential effects of pinacidil, cromakalim, and NS 1619 on electrically evoked contractions in rat vas deferens.
Topics: Animals; Benzimidazoles; Charybdotoxin; Cromakalim; Electric Stimulation; Glyburide; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth; Pinacidil; Potassium Channels; Rats; Rats, Sprague-Dawley; Vas Deferens; Vasodilator Agents | 1997 |
Control of mesenteric arterial tone in vitro in humans and rats.
Topics: Acetylcholine; Adrenergic beta-Agonists; Animals; Calcimycin; Calcium; Cromakalim; Diclofenac; Endothelium, Vascular; Enzyme Inhibitors; Female; Humans; In Vitro Techniques; Isoproterenol; Male; Mesenteric Arteries; Middle Aged; Muscle Contraction; Muscle Relaxation; Muscle Tonus; Muscle, Smooth, Vascular; NG-Nitroarginine Methyl Ester; Nitroprusside; Norepinephrine; Rats; Rats, Inbred WKY; Reference Values; Serotonin; Vasoconstrictor Agents; Vasodilator Agents | 1999 |
Novel potassium channel activators. II. Synthesis and pharmacological evaluation of 3,4-dihydro-2H-1,4-benzoxazine derivatives: modification of the aromatic part.
Topics: Animals; Antihypertensive Agents; Blood Pressure; Coronary Vessels; Cromakalim; Crystallography, X-Ray; Dogs; Female; Hypertension; In Vitro Techniques; Intracranial Pressure; Male; Muscle Contraction; Muscle, Smooth, Vascular; Oxazines; Potassium Channels; Rats; Rats, Inbred SHR; Structure-Activity Relationship | 1999 |
Involvement of ATP-sensitive potassium channels in a model of a delayed vascular hyporeactivity induced by lipopolysaccharide in rats.
Topics: Adenosine Triphosphate; Animals; Aorta, Thoracic; Blood Pressure; Cromakalim; Enzyme Inhibitors; Glyburide; Heart Rate; In Vitro Techniques; Lipopolysaccharides; Male; Muscle Contraction; Muscle, Smooth, Vascular; NG-Nitroarginine Methyl Ester; Phenylephrine; Potassium Channels; Rats; Rats, Wistar; Tetraethylammonium; Vasodilator Agents | 1999 |
Depolarization of membrane potential and the smooth muscle contraction by isothiocyanatobenzyl imidazoline in guinea-pig stomach circular muscle.
Topics: Animals; Atropine; Carbachol; Cromakalim; Dose-Response Relationship, Drug; Guinea Pigs; In Vitro Techniques; Membrane Potentials; Muscle Contraction; Muscle, Smooth; Nifedipine; Oxymetazoline; Stomach; Tolazoline; Vasodilator Agents | 1999 |
Benzylamine-related compounds stimulate rat vas deferens neurotransmission and potentiate memory in the mouse acting as potassium channel blockers.
Topics: Animals; Avoidance Learning; Benzylamines; Calcium Channel Blockers; Cromakalim; In Vitro Techniques; Injections, Intraventricular; Male; Memory; Mice; Muscle Contraction; omega-Conotoxins; Pain Measurement; Postural Balance; Potassium Channel Blockers; Rats; Reaction Time; Stimulation, Chemical; Synaptic Transmission; Vas Deferens | 2000 |
Selective inhibitory effects of niflumic acid on 5-HT-induced contraction of the rat isolated stomach fundus.
Topics: Acetylcholine; Animals; Anti-Inflammatory Agents, Non-Steroidal; Chloride Channels; Cromakalim; Diphenylamine; Gastric Fundus; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth; Nifedipine; Niflumic Acid; Potassium Chloride; Rats; Rats, Wistar; Serotonin; Vasodilator Agents | 2000 |
Vasodilator effects of KRN2391, levcromakalim and 3-morpholino-sydnonimin in human pial and omental arteries.
Topics: Aged; Arteries; ATP-Binding Cassette Transporters; Cromakalim; Enzyme Inhibitors; Guanylate Cyclase; Humans; In Vitro Techniques; KATP Channels; Middle Aged; Molsidomine; Muscle Contraction; Muscle, Smooth, Vascular; Nitric Oxide Donors; Nitric Oxide Synthase; Nitric Oxide Synthase Type III; Omentum; Pia Mater; Potassium Channels; Potassium Channels, Inwardly Rectifying; Pyridines; Regional Blood Flow; Vasodilator Agents | 2000 |
Efficacy of muscarinic stimulation and mode of excitation-contraction coupling in bovine trachealis muscle.
Topics: Acetylcholine; Animals; Calcium; Cattle; Cromakalim; Diamines; Dose-Response Relationship, Drug; Drug Interactions; In Vitro Techniques; Muscarinic Agonists; Muscle Contraction; Muscle, Smooth; Nifedipine; Phenoxybenzamine; Pilocarpine; Piperidines; Pirenzepine; Receptors, Muscarinic; Stress, Mechanical; Tetraethylammonium; Trachea | 2000 |
Low levels of K(ATP) channel activation decrease excitability and contractility of urinary bladder.
Topics: Action Potentials; Adenosine Diphosphate; Adenosine Triphosphate; Amides; Animals; Benzophenones; Cromakalim; Glyburide; Guanosine Triphosphate; Guinea Pigs; In Vitro Techniques; Muscle Contraction; Muscle, Smooth; Potassium Channels; Urinary Bladder | 2001 |
[Effects of nifedipine and cromakalim on isolated rat bladder tissue and aorta strip].
Topics: Animals; Aorta; Calcium Channel Blockers; Cromakalim; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth; Muscle, Smooth, Vascular; Nifedipine; Rats; Rats, Wistar; Urinary Bladder | 1997 |
Effects of different types of K+ channel modulators on the spontaneous myogenic contraction of guinea-pig urinary bladder smooth muscle.
Topics: 4-Aminopyridine; Animals; Anti-Arrhythmia Agents; Apamin; Barium; Benzimidazoles; Calcium Channel Blockers; Cation Transport Proteins; Cromakalim; Diltiazem; Ether-A-Go-Go Potassium Channels; Female; Glyburide; Guinea Pigs; Large-Conductance Calcium-Activated Potassium Channels; Male; Muscle Contraction; Muscle, Smooth; Nisoldipine; Parasympatholytics; Peptides; Periodicity; Piperidines; Potassium Channel Blockers; Potassium Channels; Potassium Channels, Calcium-Activated; Potassium Channels, Voltage-Gated; Pyridines; Small-Conductance Calcium-Activated Potassium Channels; Urinary Bladder | 2001 |
[Effects of emodin on the activity of K channel in guinea pig taenia coli smooth muscle cells].
Topics: Animals; Cromakalim; Dose-Response Relationship, Drug; Emodin; Female; Guinea Pigs; Male; Membrane Potentials; Muscle Contraction; Muscle, Smooth; Potassium Channel Blockers; Potassium Channels | 1998 |
Role of K+ channels in the modulation of cholinergic neural responses in guinea-pig and human airways.
Topics: Adolescent; Adult; Animals; Benzopyrans; Charybdotoxin; Cholinergic Fibers; Clonidine; Cromakalim; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Guinea Pigs; Humans; Male; Muscle Contraction; Neuropeptide Y; Potassium Channels; Pyrroles; Scorpion Venoms; Synaptic Transmission; Trachea | 1992 |
Potassium channel openers, NIP-121 and cromakalim, enhance the relaxation induced by sodium nitroprusside in the guinea-pig isolated trachea.
Topics: Animals; Benzopyrans; Cromakalim; Cyclic GMP; Drug Interactions; Epithelium; Guinea Pigs; In Vitro Techniques; Male; Muscle Contraction; Muscle Relaxation; Muscle, Smooth; Nitroprusside; Oxadiazoles; Piperidines; Potassium Channels; Pyrroles; SRS-A; Trachea; Vasodilator Agents | 1992 |
Vasodilatation of canine cerebral arteries by nicorandil, pinacidil and lemakalim.
Topics: Animals; Basilar Artery; Benzopyrans; Cerebral Arteries; Cromakalim; Dogs; Female; Glyburide; Guanidines; Guanylate Cyclase; In Vitro Techniques; Male; Methylene Blue; Muscle Contraction; Muscle, Smooth, Vascular; Niacinamide; Nicorandil; Pinacidil; Potassium Channels; Pyrroles; Vasodilation; Vasodilator Agents | 1992 |
Effect of cromakalim on the smooth muscle of the cat gastric antrum.
Topics: Action Potentials; Adenosine Triphosphate; Animals; Benzopyrans; Cats; Cromakalim; Electric Stimulation; In Vitro Techniques; Muscle Contraction; Muscle, Smooth; Parasympatholytics; Potassium Channels; Pyloric Antrum; Pyrroles | 1992 |
Effects of cromakalim on the contraction and the membrane potential of the circular smooth muscle of guinea-pig stomach.
Topics: Acetylcholine; Animals; Benzopyrans; Charybdotoxin; Cromakalim; Electric Stimulation; Glyburide; Guinea Pigs; In Vitro Techniques; Male; Membrane Potentials; Microelectrodes; Muscle Contraction; Muscle Relaxation; Muscle, Smooth; Parasympatholytics; Pyrroles; Scorpion Venoms; Stomach | 1992 |
Vasorelaxing effect in rat thoracic aorta caused by fraxinellone and dictamine isolated from the Chinese herb Dictamnus dasycarpus Turcz: comparison with cromakalim and Ca2+ channel blockers.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Alkaloids; Animals; Aorta, Thoracic; Benzofurans; Benzopyrans; Calcium; Calcium Channel Blockers; Cromakalim; Cyclic AMP; Cyclic GMP; Drugs, Chinese Herbal; Female; Glyburide; In Vitro Techniques; Male; Muscle Contraction; Muscle Relaxation; Muscle, Smooth, Vascular; Norepinephrine; Potassium Channels; Potassium Chloride; Pyrroles; Quinolines; Rats; Rats, Inbred Strains; Verapamil | 1992 |
The role of cyclic AMP in non-adrenergic non-cholinergic contraction in guinea-pig bronchi.
Topics: Animals; Autonomic Nervous System; Benzopyrans; Bronchi; Bronchodilator Agents; Bucladesine; Colforsin; Cromakalim; Cyclic AMP; Electric Stimulation; Ethanolamines; Guinea Pigs; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth; Neurons, Afferent; Nitroprusside; Procaterol; Pyrroles; Substance P; Theophylline | 1992 |
Excitation-contraction coupling in canine tracheal smooth muscle cells.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Acetylcholine; Animals; Benzopyrans; Calcium; Calcium Channels; Cromakalim; Dogs; Egtazic Acid; In Vitro Techniques; Models, Biological; Muscle Contraction; Muscle, Smooth; Nifedipine; Parasympatholytics; Pyrroles; Sarcoplasmic Reticulum; Tetraethylammonium; Tetraethylammonium Compounds; Trachea | 1992 |
Effects of K+ channel blockers on the relaxant action of dihydralazine, cromakalim and nitroprusside in isolated rabbit femoral arteries.
Topics: Animals; Benzopyrans; Cromakalim; Dihydralazine; Endothelium, Vascular; Female; Femoral Artery; In Vitro Techniques; Male; Muscle Contraction; Muscle Relaxation; Muscle, Smooth, Vascular; Nitroprusside; Norepinephrine; Potassium Channels; Pyrroles; Rabbits; Vasodilator Agents | 1992 |
Effects of imidazoline-related compounds on the mechanical response to nicorandil in the rat portal vein.
Topics: Animals; Benzopyrans; Cromakalim; Imidazoles; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth, Vascular; Niacinamide; Nicorandil; Portal Vein; Potassium Channels; Pyrroles; Rats; Rats, Wistar | 1992 |
Activation of phospholipase C by the agonist U46619 is inhibited by cromakalim-induced hyperpolarization in porcine coronary artery.
Topics: Animals; Benzopyrans; Calcium; Coronary Vessels; Cromakalim; Enzyme Activation; In Vitro Techniques; Inositol 1,4,5-Trisphosphate; Membrane Potentials; Muscle Contraction; Potassium Channels; Prostaglandin Endoperoxides, Synthetic; Pyrroles; Swine; Thromboxane A2; Type C Phospholipases | 1992 |
On the pharmacological and physiological role of glibenclamide-sensitive potassium channels in colonic smooth muscle.
Topics: Animals; Benzopyrans; Carbachol; Colforsin; Colon; Cromakalim; Dogs; Drug Interactions; Electric Stimulation; Female; Gallopamil; Glyburide; Male; Muscle Contraction; Muscle, Smooth; Potassium Channels; Pyrroles; Stereoisomerism | 1992 |
Characteristics of the contractile response of rabbit aorta produced by cromakalim in calcium-free solution.
Topics: Animals; Aorta; Benzopyrans; Calcium; Colforsin; Cromakalim; Guanidines; Male; Microelectrodes; Minoxidil; Muscle Contraction; Muscle, Smooth, Vascular; Nifedipine; Nitroglycerin; Pinacidil; Potassium; Potassium Channels; Pyridines; Pyrroles; Rabbits; Vasoconstriction | 1992 |
Effect of Rb+ on cromakalim-induced relaxation and ion fluxes in guinea pig trachea.
Topics: Albuterol; Animals; Benzopyrans; Bronchodilator Agents; Cromakalim; Guinea Pigs; In Vitro Techniques; Isoproterenol; Male; Muscle Contraction; Muscle Relaxation; Muscle, Smooth; Potassium; Pyrroles; Rubidium; Rubidium Radioisotopes; Trachea; Verapamil | 1992 |
The involvement of potassium channels in the action of ciclazindol in rat portal vein.
Topics: Animals; Benzopyrans; Cromakalim; Glyburide; In Vitro Techniques; Indoles; Male; Membrane Potentials; Muscle Contraction; Muscle, Smooth, Vascular; Portal Vein; Potassium; Potassium Channels; Pyrroles; Rats; Rats, Inbred Strains; Vasoconstriction; Vasodilator Agents | 1992 |
Comparison of the actions of acetylcholine and BRL 38227 in the guinea-pig coronary artery.
Topics: Acetylcholine; Animals; Benzopyrans; Coronary Vessels; Cromakalim; Dose-Response Relationship, Drug; Glyburide; Guinea Pigs; In Vitro Techniques; Male; Muscle Contraction; Muscle Relaxation; Muscle, Smooth, Vascular; Potassium Channels; Pyridines; Pyrroles; Rabbits; Scorpion Venoms; Vasodilator Agents | 1992 |
Effects of anti-asthma drugs and potassium channel openers on neurally-mediated contraction of isolated guinea pig trachea.
Topics: Acetylcholine; Aminophylline; Animals; Benzopyrans; Cromakalim; Electric Stimulation; Guinea Pigs; Hydrocortisone; Isoproterenol; Male; Muscle Contraction; Muscle, Smooth; Oxadiazoles; Piperidines; Potassium Channels; Pyrroles; Trachea | 1992 |
Effects of the K+ channel blocker tedisamil on 86Rb efflux induced by cromakalim, high potassium and noradrenaline, and on mechanical tension in rabbit isolated vascular smooth muscle.
Topics: Animals; Aorta; Benzopyrans; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Cardiotonic Agents; Cromakalim; Cyclopropanes; In Vitro Techniques; Muscle Contraction; Muscle Relaxation; Muscle, Smooth, Vascular; Norepinephrine; Potassium; Potassium Channels; Pyrroles; Rabbits; Rubidium | 1992 |
The inhibitory effects of cromakalim and its active enantiomer BRL 38227 against various agonists in guinea pig and human airways: comparison with pinacidil and verapamil.
Topics: Animals; Benzopyrans; Bronchi; Bronchial Spasm; Bronchodilator Agents; Carbachol; Cromakalim; Drug Interactions; Female; Guanidines; Guinea Pigs; Humans; Male; Muscle Contraction; Pinacidil; Potassium Channels; Pyrroles; Stereoisomerism; Trachea; Vasodilator Agents; Verapamil | 1992 |
Smooth muscle relaxation and inhibition of responses to pinacidil and cromakalim induced by phentolamine in guinea-pig isolated trachea.
Topics: Animals; Benzopyrans; Carbachol; Cromakalim; Dinoprost; Female; Guanidines; Guinea Pigs; Histamine; In Vitro Techniques; Male; Muscle Contraction; Muscle Relaxation; Muscle, Smooth; Phentolamine; Pinacidil; Pyrroles; SRS-A; Trachea | 1992 |
Characterization of sulfonylurea receptors and the action of potassium channel openers on cholinergic neurotransmission in guinea pig isolated small intestine.
Topics: Adenosine Triphosphate; Animals; ATP-Binding Cassette Transporters; Benzopyrans; Choline; Cromakalim; Electric Stimulation; Glyburide; Guinea Pigs; Intestine, Small; Kinetics; Male; Muscle Contraction; Muscle, Smooth; Myenteric Plexus; Picolines; Potassium Channels; Potassium Channels, Inwardly Rectifying; Pyrans; Pyrroles; Receptors, Drug; Sulfonylurea Receptors; Synaptic Transmission; Tritium | 1991 |
Effects of cromakalim on neurally-mediated responses of guinea-pig tracheal smooth muscle.
Topics: Animals; Autonomic Nervous System; Benzopyrans; Bronchodilator Agents; Cromakalim; Electric Stimulation; Female; Guinea Pigs; In Vitro Techniques; Male; Muscle Contraction; Muscle Relaxation; Muscle, Smooth; Neuromuscular Junction; Neurons; Parasympathetic Nervous System; Pyrroles; Synaptic Transmission; Trachea; Vagus Nerve | 1991 |
Existence of two components in the tonic contraction of rat aorta mediated by alpha 1-adrenoceptor activation.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adrenergic alpha-Agonists; Animals; Aorta, Thoracic; Benzopyrans; Calcium; Calcium Channel Blockers; Calcium Radioisotopes; Carbamates; Cromakalim; In Vitro Techniques; Isoquinolines; Lanthanum; Male; Muscle Contraction; Muscle Tonus; Muscle, Smooth, Vascular; Nifedipine; Phenylcarbamates; Phenylephrine; Phosphatidylinositols; Piperazines; Protease Inhibitors; Pyrroles; Rats | 1991 |
Effects of K+ channel blockers and cromakalim (BRL 34915) on the mechanical activity of guinea pig detrusor smooth muscle.
Topics: Animals; Benzopyrans; Charybdotoxin; Cromakalim; Drug Interactions; Guinea Pigs; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth; Neurotransmitter Agents; Peptides; Potassium Channels; Pyrroles; Scorpion Venoms; Vasodilator Agents | 1991 |
Cromakalim effects of acetylcholine-induced changes in cytosolic calcium and tension in swine trachealis.
Topics: Acetylcholine; Animals; Benzopyrans; Bronchodilator Agents; Calcium; Cromakalim; Cytosol; In Vitro Techniques; Male; Membrane Potentials; Muscle Contraction; Muscle, Smooth; Pyrroles; Swine; Trachea | 1992 |
Actions of cromakalim in isolated human saphenous vein.
Topics: Antihypertensive Agents; Benzopyrans; Cromakalim; Dinoprost; Glyburide; Humans; In Vitro Techniques; Muscle Contraction; Muscle Relaxation; Norepinephrine; Potassium Chloride; Pyrroles; Saphenous Vein; Serotonin; Vasoconstriction | 1992 |
Cromakalim inhibits contractions of the rat isolated mesenteric bed induced by noradrenaline but not caffeine in Ca(2+)-free medium: evidence for interference with receptor-mediated Ca2+ mobilization.
Topics: Animals; Benzopyrans; Caffeine; Calcium; Cromakalim; Culture Media; Endothelium, Vascular; In Vitro Techniques; Mesenteric Arteries; Muscle Contraction; Muscle, Smooth, Vascular; Norepinephrine; Perfusion; Pyrroles; Rats; Ryanodine; Vasodilator Agents | 1991 |
Effects of lemakalim on changes in Ca2+ concentration and mechanical activity induced by noradrenaline in the rabbit mesenteric artery.
Topics: Animals; Benzopyrans; Calcium; Cromakalim; Escin; In Vitro Techniques; Inositol 1,4,5-Trisphosphate; Isometric Contraction; Male; Membrane Potentials; Mesenteric Arteries; Muscle Contraction; Muscle, Smooth, Vascular; Myelin Sheath; Neuromuscular Depolarizing Agents; Norepinephrine; Pyrroles; Rabbits; Vasodilator Agents | 1991 |
Inhibition by glibenclamide of the effects of cromakalim on responses of rat vas deferens to naphazoline.
Topics: Animals; Benzopyrans; Cromakalim; Glyburide; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth; Naphazoline; Parasympatholytics; Potassium Channels; Pyrroles; Rats; Rats, Inbred Strains; Vas Deferens | 1991 |
The effect of potassium channel opening drugs on pulmonary nerves.
Topics: Acetylcholine; Animals; Benzopyrans; Cromakalim; Electric Stimulation; Glyburide; Guinea Pigs; In Vitro Techniques; Lung; Muscle Contraction; Parasympathetic Nervous System; Parasympatholytics; Pyrroles; Trachea | 1991 |
The relationship of KCl- and prostaglandin F2 alpha-mediated increases in tension of the porcine coronary artery with changes in intracellular Ca2+ measured with fura-2.
Topics: Animals; Arteries; Benzopyrans; Biomechanical Phenomena; Calcium; Coronary Vessels; Cromakalim; Dinoprost; Fura-2; Membrane Potentials; Muscle Contraction; Muscle Tonus; Muscle, Smooth, Vascular; Nitroprusside; Potassium Chloride; Pyrroles; Swine; Vasodilator Agents | 1991 |
Antidiabetic sulfonylureas relax isolated rabbit coronary arteries.
Topics: Animals; Benzopyrans; Coronary Vessels; Cromakalim; Dinoprost; Hypoglycemic Agents; In Vitro Techniques; Muscle Contraction; Muscle Relaxation; Muscle, Smooth, Vascular; Potassium; Pyrroles; Rabbits; Sulfonylurea Compounds; Vasodilator Agents | 1991 |
NIP-121 and cromakalim, potassium channel openers, preferentially suppress prostanoid-induced contraction of the guinea-pig isolated trachea.
Topics: Animals; Arachidonic Acid; Benzopyrans; Cromakalim; Dinoprost; Glyburide; Guinea Pigs; Indomethacin; Male; Muscle Contraction; Muscle Relaxation; Muscle, Smooth; Oxadiazoles; Piperidines; Potassium Channels; Prostaglandin D2; Prostaglandin Endoperoxides, Synthetic; Prostaglandins; Pyrroles; Sulfonamides; Trachea | 1991 |
The dualistic mode of action of the vasodilator drug, nicorandil, differentiated by glibenclamide in 86Rb flux studies in rabbit isolated vascular smooth muscle.
Topics: Animals; Aorta; Benzopyrans; Cromakalim; Glyburide; Membranes; Muscle Contraction; Muscle, Smooth, Vascular; Niacinamide; Nicorandil; Norepinephrine; Potassium; Potassium Channels; Pyrroles; Rabbits; Rubidium Radioisotopes; Stimulation, Chemical; Vasodilator Agents | 1991 |
Differential antagonism by glibenclamide of the relaxant effects of cromakalim, pinacidil and nicorandil on canine large coronary arteries.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Animals; Arteries; Benzopyrans; Coronary Vessels; Cromakalim; Dogs; Dose-Response Relationship, Drug; Female; Glyburide; Guanidines; Male; Methylene Blue; Muscle Contraction; Muscle, Smooth, Vascular; Niacinamide; Nicorandil; Nitroglycerin; Pinacidil; Potassium; Prostaglandin Endoperoxides, Synthetic; Pyrroles; Vasodilator Agents | 1991 |
The effect of cromakalim on the normal and hyper-reflexic human detrusor muscle.
Topics: Acetylcholine; Benzopyrans; Cromakalim; Dose-Response Relationship, Drug; Electric Stimulation; Humans; In Vitro Techniques; Muscle Contraction; Muscle, Smooth; Parasympatholytics; Pyrroles; Urinary Bladder | 1991 |
The diverse effects of cromakalim on tension and 86Rb efflux in canine arterial smooth muscle.
Topics: Animals; Arteries; Benzopyrans; Cromakalim; Dogs; Female; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth, Vascular; Nifedipine; Potassium Channels; Pyrroles; Rubidium Radioisotopes | 1991 |
Comparison of the effects of the K(+)-channel openers cromakalim and minoxidil sulphate on vascular smooth muscle.
Topics: Animals; Aorta, Thoracic; Benzopyrans; Cromakalim; Female; Guinea Pigs; In Vitro Techniques; Male; Mesenteric Arteries; Minoxidil; Muscle Contraction; Muscle, Smooth, Vascular; Norepinephrine; Portal Vein; Potassium Channels; Pyrroles; Rabbits; Vasodilator Agents | 1991 |
Effects of glibenclamide on cytosolic calcium concentrations and on contraction of the rabbit aorta.
Topics: Animals; Aorta, Thoracic; Benzopyrans; Calcium; Cromakalim; Cytosol; Fura-2; Glyburide; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth, Vascular; Norepinephrine; Potassium; Pyrroles; Rabbits | 1991 |
Evidence that acetylcholine-mediated hyperpolarization of the rat small mesenteric artery does not involve the K+ channel opened by cromakalim.
Topics: Acetylcholine; Animals; Benzopyrans; Cromakalim; Electrophysiology; Glyburide; In Vitro Techniques; Membrane Potentials; Mesenteric Arteries; Muscle Contraction; Muscle, Smooth, Vascular; Phentolamine; Potassium Channels; Pyrroles; Rats; Rats, Inbred WKY; Swine; Vasodilator Agents | 1991 |
Some degree of overlap exists between the K(+)-channels opened by cromakalim and those opened by minoxidil sulphate in rat isolated aorta.
Topics: Animals; Aorta, Thoracic; Benzopyrans; Cromakalim; Glyburide; In Vitro Techniques; Male; Minoxidil; Muscle Contraction; Muscle, Smooth, Vascular; Potassium; Potassium Channels; Potassium Radioisotopes; Pyrroles; Rats; Rats, Inbred Strains; Rubidium; Rubidium Radioisotopes; Vasodilator Agents | 1991 |
Effects of cromakalim (BRL 34915) on mechanical responses of rat vas deferens to noradrenaline and naphazoline.
Topics: Animals; Benzopyrans; Cromakalim; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth; Naphazoline; Norepinephrine; Parasympatholytics; Potassium Channels; Pyrroles; Rats; Rats, Inbred Strains; Vas Deferens; Verapamil | 1991 |
Experimental hyperreflexia: effect of intravesical administration of various agents.
Topics: Animals; Benzopyrans; Blood Pressure; Cromakalim; Diltiazem; Electric Stimulation; Electromyography; Hexamethonium Compounds; Male; Muscle Contraction; Nifedipine; Pyrroles; Rabbits; Reflex; Urinary Bladder Diseases; Vasodilator Agents; Verapamil | 1991 |
Evidence that pinacidil may promote the opening of ATP-sensitive K+ channels yet inhibit the opening of Ca2(+)-activated K+ channels in K(+)-contracted canine mesenteric artery.
Topics: Adenosine Triphosphate; Animals; Benzopyrans; Calcium; Cromakalim; Dogs; Female; Glyburide; Guanidines; In Vitro Techniques; Male; Mesenteric Arteries; Muscle Contraction; Muscle Relaxation; Muscle, Smooth, Vascular; Nifedipine; Pinacidil; Potassium; Potassium Channels; Pyrroles; Rubidium Radioisotopes | 1990 |
Characterization of responses to cromakalim and pinacidil in smooth and cardiac muscle by use of selective antagonists.
Topics: Animals; Aorta, Thoracic; Benzopyrans; Clonidine; Coronary Vessels; Cromakalim; Dogs; Electric Stimulation; Glyburide; Guanidines; Guinea Pigs; Heart; In Vitro Techniques; Isoproterenol; Muscle Contraction; Muscle, Smooth; Muscle, Smooth, Vascular; Myocardial Contraction; Phentolamine; Pinacidil; Potassium Channels; Pyrroles; Rats | 1990 |
Hypoglycemic sulfonylureas antagonize the effects of cromakalim and pinacidil on 86Rb fluxes and contractile activity in the rat aorta.
Topics: Animals; Aorta, Thoracic; Benzopyrans; Cromakalim; Glyburide; Guanidines; Hypoglycemic Agents; In Vitro Techniques; Muscle Contraction; Muscle Relaxation; Muscle, Smooth, Vascular; Nitroprusside; Parasympatholytics; Pinacidil; Potassium Channels; Pyrroles; Rats; Rats, Inbred Strains; Rubidium Radioisotopes; Sulfonylurea Compounds; Tetraethylammonium Compounds; Tolbutamide; Vasodilator Agents | 1990 |
Cytoplasmic calcium and the relaxation of canine coronary arterial smooth muscle produced by cromakalim, pinacidil and nicorandil.
Topics: Adenosine Triphosphate; Animals; Benzopyrans; Calcium; Coronary Vessels; Cromakalim; Cytoplasm; Dogs; Female; Fluorescence; Glyburide; Guanidines; In Vitro Techniques; Male; Muscle Contraction; Muscle Relaxation; Muscle, Smooth, Vascular; Niacinamide; Nicorandil; Pinacidil; Potassium Chloride; Pyrroles; Quaternary Ammonium Compounds | 1990 |
Endothelium-dependent and BRL 34915-induced vasodilatation in rat isolated perfused mesenteric arteries: role of G-proteins, K+ and calcium channels.
Topics: Acetylcholine; Animals; Benzopyrans; Calcimycin; Calcium Channel Blockers; Calcium Channels; Cromakalim; Endothelium, Vascular; GTP-Binding Proteins; Histamine; In Vitro Techniques; Male; Mesenteric Arteries; Muscle Contraction; Muscle, Smooth, Vascular; Nitric Oxide; Pertussis Toxin; Potassium Channels; Pyrroles; Rats; Vasodilator Agents; Virulence Factors, Bordetella | 1990 |
Mechanisms of inhibitory effects of CD-349 and K(+)-channel activators on noradrenaline-induced contraction and changes in levels of cyclic GMP in rat aorta.
Topics: Animals; Aorta, Thoracic; Benzopyrans; Calcium Channel Agonists; Calcium Channel Blockers; Cromakalim; Cyclic GMP; Dihydropyridines; Glyburide; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth, Vascular; Norepinephrine; Potassium Channels; Pyrroles; Rats; Rats, Inbred Strains | 1990 |
An approach to differentiate between noradrenaline-elicited contractile processes in the rat isolated aorta.
Topics: Animals; Aorta, Thoracic; Benzopyrans; Calcium; Calcium Channel Blockers; Cromakalim; In Vitro Techniques; Muscle Contraction; Muscle, Smooth, Vascular; Norepinephrine; Protein Kinase C; Pyrroles; Rats; Rats, Inbred Strains; Ryanodine | 1990 |
Non-junctional modulation of neurogenic twitches of the guinea-pig ileum by some peptides and other compounds in the triple bath.
Topics: Action Potentials; Animals; Benzopyrans; Bradykinin; Capsaicin; Cromakalim; Guinea Pigs; Ileum; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth; Neural Conduction; Neurotensin; Peptides; Pyrroles; Vasoactive Intestinal Peptide | 1990 |
K+ channel openers suppress myotonic activity of human skeletal muscle in vitro.
Topics: Benzopyrans; Cell Membrane Permeability; Cromakalim; Dihydropyridines; Humans; In Vitro Techniques; Microelectrodes; Muscle Contraction; Muscles; Potassium Channels; Pyrroles; Vasodilator Agents | 1990 |
Effects of cromakalim (BRL 34915) and pinacidil on normal and hypertrophied rat detrusor in vitro.
Topics: Animals; Benzopyrans; Carbachol; Cromakalim; Dose-Response Relationship, Drug; Electric Stimulation; Female; Guanidines; Hypertrophy; In Vitro Techniques; Muscle Contraction; Pinacidil; Potassium; Pyrroles; Rats; Rats, Inbred Strains; Urinary Bladder; Vasodilator Agents | 1990 |
Enhancement of K+ conductance improves in vitro the contraction force of skeletal muscle in hypokalemic periodic paralysis.
Topics: Benzopyrans; Cromakalim; Humans; Hypokalemia; In Vitro Techniques; Muscle Contraction; Muscles; Paralyses, Familial Periodic; Potassium Channels; Pyrroles | 1990 |
K(+)-channel openers for relaxation of isolated penile erectile tissue from rabbit.
Topics: Animals; Benzopyrans; Cromakalim; Electric Stimulation; Guanidines; In Vitro Techniques; Male; Muscle Contraction; Muscle Relaxation; Muscle, Smooth, Vascular; Norepinephrine; Papaverine; Penile Erection; Penis; Pinacidil; Potassium; Potassium Channels; Pyrroles; Rabbits; Vasodilator Agents | 1990 |
Differences in Ca2+ handling along the arterial tree: an update including studies in human mesenteric resistance vessels.
Topics: Animals; Antihypertensive Agents; Arteries; Benzopyrans; Calcium; Calcium Channel Blockers; Cromakalim; Humans; In Vitro Techniques; Membrane Potentials; Mesenteric Arteries; Muscle Contraction; Norepinephrine; Pyrroles; Rabbits; Rats; Rats, Inbred Strains; Rats, Inbred WKY; Vascular Resistance | 1988 |
Endothelin-1-induced contractions of vascular and tracheal smooth muscle: effects of nicardipine and BRL 34915.
Topics: Animals; Aorta, Thoracic; Benzopyrans; Cromakalim; Endothelins; Guinea Pigs; In Vitro Techniques; Muscle Contraction; Muscle, Smooth; Muscle, Smooth, Vascular; Nicardipine; Parasympatholytics; Peptides; Pyrroles; Rats; Trachea | 1989 |
Effects of cromakalim and glibenclamide on isolated strips of bovine tracheal smooth muscle. Smooth Muscle Research Group.
Topics: Animals; Benzopyrans; Cattle; Cromakalim; Glyburide; In Vitro Techniques; Muscle Contraction; Muscle, Smooth; Parasympatholytics; Pyrroles; Rubidium Radioisotopes; Trachea | 1989 |
Effect of cromakalim on smooth muscle cells of guinea-pig taenia caeci.
Topics: Animals; Benzopyrans; Cecum; Cromakalim; Electrophysiology; Female; Glyburide; Guinea Pigs; In Vitro Techniques; Male; Membrane Potentials; Muscle Contraction; Muscle, Smooth; Parasympatholytics; Pyrroles | 1989 |
Glibenclamide is a competitive antagonist of cromakalim, pinacidil and RP 49356 in guinea-pig pulmonary artery.
Topics: Animals; Benzopyrans; Cromakalim; Glyburide; Guanidines; Guinea Pigs; In Vitro Techniques; Male; Methylene Blue; Muscle Contraction; Muscle Relaxation; Muscle, Smooth, Vascular; Niacinamide; Nicorandil; Picolines; Pinacidil; Potassium Channels; Potassium Chloride; Pulmonary Artery; Purinones; Pyrans; Pyrroles; Tetraethylammonium Compounds | 1989 |
Functional changes in potassium channels in aortas from rats with streptozotocin-induced diabetes.
Topics: Animals; Aorta, Thoracic; Benzopyrans; Blood Glucose; Cromakalim; Diabetes Mellitus, Experimental; In Vitro Techniques; Male; Muscle Contraction; Muscle Relaxation; Niacinamide; Nicorandil; Norepinephrine; Parasympatholytics; Potassium Channels; Pyrroles; Rats; Rats, Inbred Strains | 1989 |
Effect of cromakalim on contractions in rabbit isolated renal artery in the presence and absence of extracellular Ca2+.
Topics: Animals; Benzopyrans; Caffeine; Calcium; Calcium Channel Blockers; Cromakalim; Guanidines; Guanylate Cyclase; Histamine; In Vitro Techniques; Lanthanum; Male; Muscle Contraction; Muscle, Smooth, Vascular; Nifedipine; Nitroprusside; Norepinephrine; Pinacidil; Pyrroles; Rabbits; Renal Artery; Vasodilator Agents | 1989 |
The effects of cromakalim on the detrusor muscle of human and pig urinary bladder.
Topics: Animals; Benzopyrans; Cromakalim; Female; Humans; Male; Membrane Potentials; Muscle Contraction; Muscle, Smooth; Potassium Channels; Pyrroles; Swine; Urinary Bladder | 1989 |
The effect of cromakalim on the smooth muscle of the guinea-pig urinary bladder.
Topics: Animals; Benzopyrans; Cromakalim; Electrophysiology; Guinea Pigs; In Vitro Techniques; Muscle Contraction; Muscle, Smooth; Parasympatholytics; Potassium; Potassium Radioisotopes; Pyrroles; Rubidium Radioisotopes; Urinary Bladder | 1989 |
The effect of relaxants working through different transduction mechanisms on the tonic contraction produced in rat aorta by 4 beta-phorbol dibutyrate.
Topics: Animals; Aorta, Thoracic; Benzopyrans; Colforsin; Cromakalim; In Vitro Techniques; Isoproterenol; Male; Methoxamine; Muscle Contraction; Muscle Relaxation; Muscle, Smooth, Vascular; Nitroprusside; Parasympatholytics; Phorbol 12,13-Dibutyrate; Pyrroles; Rats; Rats, Inbred Strains; Xanthines | 1989 |
Anti-spasmogenic and spasmolytic effects of BRL 34915: a comparison with nifedipine and nicorandil.
Topics: Animals; Benzopyrans; Cromakalim; Electric Stimulation; In Vitro Techniques; Male; Mesenteric Arteries; Muscle Contraction; Muscle, Smooth, Vascular; Niacinamide; Nicorandil; Nifedipine; Norepinephrine; Parasympatholytics; Potassium Chloride; Pyrroles; Rabbits | 1987 |
Effect of the K+ efflux stimulating vasodilator BRL 34915 on 86Rb+ efflux and spontaneous activity in guinea-pig portal vein.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Animals; Antihypertensive Agents; Benzopyrans; Bucladesine; Cromakalim; Drug Interactions; Guinea Pigs; In Vitro Techniques; Muscle Contraction; Muscle, Smooth, Vascular; Portal Vein; Potassium; Pyrroles; Radioisotopes; Rubidium; Vasodilator Agents | 1987 |
Dissociation of actions of BRL 34915 in the rat portal vein.
Topics: Animals; Antihypertensive Agents; Benzopyrans; Cromakalim; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth, Vascular; Norepinephrine; Portal Vein; Potassium; Potassium Radioisotopes; Pyrroles; Rats; Rats, Inbred Strains | 1987 |
Comparison of the effects of BRL 34915 and verapamil on electrical and mechanical activity in rat portal vein.
Topics: Animals; Antihypertensive Agents; Benzopyrans; Cromakalim; In Vitro Techniques; Male; Membrane Potentials; Microelectrodes; Muscle Contraction; Muscle, Smooth, Vascular; Norepinephrine; Portal Vein; Pyrroles; Rats; Rats, Inbred Strains; Verapamil | 1986 |
3-Methyl-2H-1-benzopyran potassium channel activators.
Topics: Acetylcholine; Animals; Benzopyrans; Coronary Vessels; Membrane Potentials; Molecular Conformation; Muscle Contraction; Muscle Relaxation; Muscle, Smooth, Vascular; Potassium Channels; Pulmonary Artery; Rabbits; Structure-Activity Relationship; Swine | 1991 |
Cardioselective antiischemic ATP-sensitive potassium channel openers. 2. Structure-activity studies on benzopyranylcyanoguanidines: modification of the benzopyran ring.
Topics: Adenosine Triphosphate; Animals; Aorta; Benzopyrans; Guanidines; Heart; Ion Channel Gating; Male; Muscle Contraction; Muscle Relaxation; Muscle, Smooth, Vascular; Myocardial Ischemia; Potassium Channels; Rats; Rats, Inbred WKY; Rats, Sprague-Dawley; Sensitivity and Specificity; Structure-Activity Relationship | 1995 |
Novel potassium-channel openers: preparation and pharmacological evaluation of racemic and optically active N-(6-amino-3-pyridyl)-N'-bicycloalkyl-N"-cyanoguanidine derivatives.
Topics: Animals; Antihypertensive Agents; Aorta; Blood Pressure; Bridged Bicyclo Compounds; Chromatography, High Pressure Liquid; Crystallography, X-Ray; Diuretics; Guanidines; Hypotension; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth, Vascular; Potassium Channels; Rats; Rats, Inbred SHR; Rats, Wistar; Stereoisomerism | 1994 |
N-aryl-3,3,3-trifluoro-2-hydroxy-2-methylpropanamides: KATP potassium channel openers. Modifications on the western region.
Topics: Amides; Animals; Cricetinae; In Vitro Techniques; Muscle Contraction; Muscle, Smooth; Potassium Channels; Rats; Structure-Activity Relationship; Urinary Bladder; Urinary Incontinence | 1996 |
Cardioselective antiischemic ATP-sensitive potassium channel (K(ATP)) openers. 6. Effect of modifications at C6 of benzopyranyl cyanoguanidines.
Topics: Animals; Benzopyrans; Cardiotonic Agents; Glyburide; Guanidines; Heart; Muscle Contraction; Myocardial Ischemia; Potassium Channels; Rats; Vasodilation; Vasodilator Agents | 1999 |
Structure-activity relationship of a novel class of naphthyl amide KATP channel openers.
Topics: Amides; Animals; ATP-Binding Cassette Transporters; Blood Pressure; Cell Line; Fluorescent Dyes; Humans; Hypertrophy; Male; Membrane Potentials; Muscle Contraction; Naphthalenes; Potassium Channels; Potassium Channels, Inwardly Rectifying; Rats; Rats, Sprague-Dawley; Receptors, Drug; Structure-Activity Relationship; Sulfonylurea Receptors; Swine; Transfection; Urinary Bladder | 2003 |