cromakalim has been researched along with Hypertension in 38 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 5 (13.16) | 18.7374 |
| 1990's | 22 (57.89) | 18.2507 |
| 2000's | 9 (23.68) | 29.6817 |
| 2010's | 2 (5.26) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| De Keulenaer, GW; De Meyer, GR; Fransen, P; Leloup, AJ; Schrijvers, DM; Van Hove, CE | 1 |
| Chen, CM; Ko, WC; Lin, YJ; Shih, CH | 1 |
| Goyal, RK; Kulkarni, JS; Metha, AA; Santani, DD | 1 |
| Dojo, M; Hatano, Y; Iranami, H; Kimoto, Y; Kinoshita, H; Nakahata, K | 1 |
| Ghosh, M; Hanna, ST; McNeill, JR; Wang, R | 1 |
| Chen, X; Connors, SG; Mendonca, M; Patel, K; Welch, WJ; Wilcox, CS | 1 |
| Aras-López, R; Balfagon, G; Blanco-Rivero, J; Cobeño, L; Cogolludo, A; Ferrer, M; Gamallo, C; Pérez-Vizcaino, F | 1 |
| Hashimoto, T; Kusano, S; Suzuki, S; Yano, K | 1 |
| Kam, KL; Pfaffendorf, M; van Zwieten, PA | 2 |
| Do, ML; Halterman, TJ; Howe, BB; Kau, ST; Li, JH; McConville, MW; Trivedi, S; Yochim, CL; Zografos, P | 1 |
| Clapham, JC; Hamilton, TC; Trail, BK | 1 |
| Addo, MF; Falotico, R; Giardino, E; Haertlein, BJ; Katz, LB; Loughney, D; McNally, JJ; Press, JB; Sanfilippo, PJ | 1 |
| Igata, Y; Ikeda, S; Maekawa, T; Shiraishi, M; Watanabe, T; Yamamoto, S | 1 |
| Lee, BH; Oh, JH; Seo, HW; Shin, HS | 1 |
| Kwan, YW; Lau, WM; To, KW; Tsang, SH | 1 |
| Izawa, T; Kashiwabara, T; Kawahara, J; Ogawa, N; Okada, Y | 1 |
| Masuda, N; Matsuhisa, A; Matsumoto, Y; Nohira, H; Shibanuma, T; Tsuzuki, R; Yamagiwa, Y; Yanagisawa, I | 1 |
| Holm, P; Hutri-Kähönen, N; Jolma, P; Kähönen, M; Kalliovalkama, J; Pörsti, I; Tolvanen, JP; Wu, X | 1 |
| Cheng, CY; Lee, YM; Peng, YY; Sheu, JR; Yen, MH | 1 |
| Abe, I; Fujii, K; Fujishima, M; Goto, K; Onaka, U | 1 |
| Abe, I; Fujii, K; Goto, K | 1 |
| Hatano, Y; Iranami, H; Kakutani, T; Kinoshita, H | 1 |
| Obiefuna, IP; Obiefuna, PC | 1 |
| Messing, MW; Struijker Boudier, HA; van Essen, H | 1 |
| Armstrong, JM; Barras, M; Hicks, PE; Lawson, K; Martin, DJ; Zazzi-Sudriez, E | 1 |
| Donnelly, R; Elliott, HL; Meredith, PA; Reid, JL | 1 |
| Berdeaux, A; Giudicelli, JF; Richer, C | 1 |
| Grose, JH; Lacourcière, Y; Lebel, M | 2 |
| Haeusler, G | 1 |
| Miyata, N; Otomo, S; Tsuchida, K | 1 |
| Burrell, G; Cassidy, F; Evans, JM; Lightowler, D; Stemp, G | 1 |
| Abe, Y; Aki, Y; Fukui, K; Iwao, H; Shoji, T; Tamaki, T | 1 |
| MacGregor, GA; Markandu, ND; Miller, MA; Singer, DR; Sugden, AL | 1 |
| Carey, OJ; Davies, BE; Fleming, JJ; Ward, JW | 1 |
| Cheung, WM; Falotico, R; Haertlein, B; Keiser, J; Tobia, A | 1 |
| Buckingham, RE | 1 |
1 review(s) available for cromakalim and Hypertension
| Article | Year |
|---|---|
K(+)-channel openers: new antihypertensive drugs?
Topics: Antihypertensive Agents; Benzopyrans; Cromakalim; Dihydropyridines; Guanidines; Hemodynamics; Humans; Hypertension; Molecular Structure; Pinacidil; Potassium Channels; Pyrroles | 1990 |
3 trial(s) available for cromakalim and Hypertension
| Article | Year |
|---|---|
Antihypertensive effect of levcromakalim in patients with essential hypertension. Study by 24-h ambulatory blood pressure monitoring.
Topics: Adult; Aged; Antihypertensive Agents; Benzopyrans; Blood Pressure Monitoring, Ambulatory; Circadian Rhythm; Cromakalim; Female; Humans; Hypertension; Male; Middle Aged; Pulse; Pyrroles | 1995 |
Effect of short-term administration of cromakalim on renal hemodynamics and eicosanoid excretion in essential hypertension.
Topics: Adult; Antihypertensive Agents; Atrial Natriuretic Factor; Benzopyrans; Blood Pressure; Chlorides; Cromakalim; Dinoprost; Dinoprostone; Eicosanoids; Female; Glomerular Filtration Rate; Heart Rate; Hemodynamics; Humans; Hypertension; Kidney; Male; Middle Aged; Potassium; Prostaglandins; Pyrroles; Regional Blood Flow; Renin-Angiotensin System; Sodium; Thromboxane B2; Time Factors; Vascular Resistance | 1991 |
Potassium channel stimulation in normal subjects and in patients with essential hypertension: an acute study with cromakalim (BRL 34915).
Topics: Antihypertensive Agents; Benzopyrans; Blood Pressure; Cromakalim; Double-Blind Method; Female; Humans; Hypertension; Kidney; Male; Middle Aged; Potassium Channels; Pyrroles; Randomized Controlled Trials as Topic; Renin-Angiotensin System; Stimulation, Chemical; Time Factors | 1989 |
34 other study(ies) available for cromakalim and Hypertension
| Article | Year |
|---|---|
Effect of angiotensin II-induced arterial hypertension on the voltage-dependent contractions of mouse arteries.
Topics: Action Potentials; Angiotensin II; Animals; Arteries; Blood Pressure; Calcium Channel Blockers; Calcium Channels, L-Type; Cromakalim; Diltiazem; Hypertension; Male; Mice; Mice, Inbred C57BL; Muscle Contraction; Muscle, Smooth, Vascular; Nitric Oxide; Potassium; Vasodilation | 2016 |
Butylidenephthalide antagonizes cromakalim-induced systolic pressure reduction in conscious normotensive rats.
Topics: Animals; Blood Pressure; Cromakalim; Humans; Hypertension; Hypoglycemic Agents; Male; Molecular Structure; Phthalic Anhydrides; Potassium Channels; Rats; Rats, Inbred SHR | 2015 |
Effects of chronic treatment with cromakalim and glibenclamide in alloxan-induced diabetic rats.
Topics: Animals; Antihypertensive Agents; Blood Glucose; Blood Pressure; Cromakalim; Diabetes Mellitus, Experimental; Drug Interactions; Female; Glyburide; Heart Rate; Hypertension; Hypoglycemic Agents; Rats; Rats, Wistar | 2002 |
Mexiletine differentially modulates vasorelaxation mediated by adenosine triphosphate-sensitive K+ channels in aortas from normotensive and hypertensive rats.
Topics: Animals; Anti-Arrhythmia Agents; Aorta, Thoracic; ATP-Binding Cassette Transporters; Cromakalim; Dose-Response Relationship, Drug; Glyburide; Hypertension; Hypoglycemic Agents; KATP Channels; Male; Mexiletine; Muscle Relaxation; Muscle, Smooth, Vascular; Nitric Oxide Donors; Nitroprusside; Phenylephrine; Potassium Channels; Potassium Channels, Inwardly Rectifying; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Vasoconstrictor Agents; Vasodilation; Vasodilator Agents | 2003 |
Altered vascular reactivity and KATP channel currents in vascular smooth muscle cells from deoxycorticosterone acetate (DOCA)-salt hypertensive rats.
Topics: Adenosine Triphosphate; Animals; Aorta, Thoracic; Blood Pressure; Canada; Cromakalim; Desoxycorticosterone; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Implants; Electrophysiology; Endothelium, Vascular; Glyburide; Hypertension; Male; Membrane Potentials; Muscle, Smooth, Vascular; Nephrectomy; Phenylephrine; Potassium Channels; Potassium Chloride; Rats; Rats, Sprague-Dawley; Vasoconstriction; Vasodilation | 2004 |
Acute antihypertensive action of Tempol in the spontaneously hypertensive rat.
Topics: Amitrole; Animals; Antihypertensive Agents; Blood Pressure; Buthionine Sulfoximine; Catalase; Cromakalim; Cyclic N-Oxides; Disease Models, Animal; Dose-Response Relationship, Drug; Enzyme Inhibitors; Ganglionic Blockers; Glutathione Peroxidase; Glyburide; Heart Rate; Heme Oxygenase (Decyclizing); Hexamethonium; Hypertension; Infusions, Intravenous; KATP Channels; Large-Conductance Calcium-Activated Potassium Channels; Male; Metalloporphyrins; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Peptides; Potassium Channel Blockers; Rats; Rats, Inbred SHR; Spin Labels; Sympathetic Nervous System; Time Factors | 2007 |
Decreased expression of aortic KIR6.1 and SUR2B in hypertension does not correlate with changes in the functional role of K(ATP) channels.
Topics: Animals; Antihypertensive Agents; Aorta, Thoracic; ATP-Binding Cassette Transporters; Blotting, Western; Cromakalim; Glyburide; Hypertension; Hypoglycemic Agents; Immunohistochemistry; KATP Channels; Male; Muscle, Smooth, Vascular; Patch-Clamp Techniques; Pinacidil; Potassium Channels, Inwardly Rectifying; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Receptors, Drug; Sulfonylurea Receptors | 2008 |
Drug-induced endothelium-dependent and -independent relaxations in isolated resistance vessels taken from simultaneously hypertensive and streptozotocin-diabetic rats.
Topics: Animals; Benzopyrans; Bradykinin; Calcium; Cromakalim; Diabetes Mellitus, Experimental; Endothelium, Vascular; Glyburide; Histamine; Hypertension; Male; Mesenteric Arteries; Methacholine Chloride; Muscle Relaxation; Muscle, Smooth, Vascular; Nifedipine; Nitroprusside; Potassium Channels; Potassium Chloride; Pyrroles; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Streptozocin; Vascular Resistance; Vasodilation; Vasodilator Agents | 1994 |
Characterization of ATP-sensitive potassium channel-blocking activity of ZENECA ZM181,037, a eukalemic diuretic.
Topics: Acetamides; Adenosine Triphosphate; Administration, Oral; Animals; Benzopyrans; Blood Glucose; Blood Pressure; Cromakalim; Diuretics; Dogs; Dose-Response Relationship, Drug; Electrophysiology; Glyburide; Guinea Pigs; Hypertension; In Vitro Techniques; Injections, Intravenous; Male; Muscle Relaxation; Muscle, Smooth; Muscle, Smooth, Vascular; Potassium Channel Blockers; Pyrroles; Rats; Rats, Inbred SHR; Rats, Sprague-Dawley; Stereoisomerism; Tolbutamide | 1994 |
K+ channel activators, acute glucose tolerance and glibenclamide-induced hypoglycaemia in the hypertensive rat.
Topics: Administration, Oral; Animals; Antihypertensive Agents; Benzopyrans; Blood Glucose; Blood Pressure; Cromakalim; Diazoxide; Dose-Response Relationship, Drug; Glucose Tolerance Test; Glyburide; Guanidines; Hypertension; Hypoglycemia; Pinacidil; Potassium Channels; Pyrroles; Rats; Rats, Inbred SHR | 1994 |
Novel thieno[2,3-b]- and [3,4-b]pyrans as potassium channel openers. Thiophene systems--XVII.
Topics: Animals; Antihypertensive Agents; Aorta; Benzopyrans; Cromakalim; Drug Evaluation, Preclinical; Glyburide; Hypertension; In Vitro Techniques; Models, Molecular; Molecular Structure; Potassium Channels; Pyrroles; Rats; Rats, Inbred SHR; Structure-Activity Relationship; Thiophenes | 1993 |
Pharmacodynamic behaviour of isolated resistance vessels obtained from hypertensive-diabetic rats.
Topics: Animals; Benzopyrans; Blood Glucose; Calcium Channels; Calcium Chloride; Cromakalim; Glyburide; Hypertension; In Vitro Techniques; Male; Mesenteric Arteries; Methacholine Chloride; Methoxamine; Muscle Contraction; Muscle, Smooth; Nifedipine; Nitroprusside; Norepinephrine; Obesity; Potassium Channels; Potassium Chloride; Pyrroles; Rats; Rats, Zucker; Serotonin; Tunica Media; Vascular Resistance; Vasoconstrictor Agents; Vasodilator Agents | 1996 |
Synthesis and biological activity of novel 2-(alpha-alkoxyimino)benzylpyridine derivatives as K+ channel openers.
Topics: Administration, Oral; Animals; Aorta, Thoracic; Blood Pressure; Coronary Circulation; Cromakalim; Cyclic N-Oxides; Diltiazem; Dogs; Hypertension; Male; Muscle, Smooth, Vascular; Niacinamide; Nicorandil; Nitroglycerin; Potassium Channels; Pyridines; Rats; Rats, Inbred SHR; Rats, Wistar; Structure-Activity Relationship; Vasodilation; Vasodilator Agents | 1997 |
Antihypertensive effects of the novel potassium channel activator SKP-450 and its major metabolites in rats.
Topics: Animals; Antihypertensive Agents; Benzopyrans; Blood Pressure; Cromakalim; Desoxycorticosterone; Heart Rate; Hypertension; Hypertension, Renal; Male; Potassium Channels; Pyrroles; Pyrrolidinones; Rats; Rats, Inbred SHR; Vasodilator Agents | 1998 |
Comparison of the vascular relaxant effects of ATP-dependent K+ channel openers on aorta and pulmonary artery isolated from spontaneously hypertensive and Wistar-Kyoto rats.
Topics: Adenosine Triphosphate; Aminoquinolines; Animals; Aorta, Thoracic; Apamin; Benzopyrans; Charybdotoxin; Cromakalim; Dose-Response Relationship, Drug; Glyburide; Hypertension; In Vitro Techniques; Male; Muscle Relaxation; Muscle, Smooth, Vascular; NG-Nitroarginine Methyl Ester; Nicorandil; Nitroprusside; Norepinephrine; Picolines; Pinacidil; Potassium; Potassium Channels; Pulmonary Artery; Pyrans; Pyrrolidinones; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Vasodilator Agents | 1999 |
Antihypertensive properties of KRN4884, a novel long-lasting potassium channel opener.
Topics: Animals; Antihypertensive Agents; Aorta, Thoracic; Blood Pressure; Calcium Channel Blockers; Cromakalim; Dose-Response Relationship, Drug; Hypertension; In Vitro Techniques; Male; Nifedipine; Pyridines; Rats; Rats, Inbred SHR; Rats, Wistar; Time Factors; Vasodilation | 1999 |
Novel potassium channel activators. II. Synthesis and pharmacological evaluation of 3,4-dihydro-2H-1,4-benzoxazine derivatives: modification of the aromatic part.
Topics: Animals; Antihypertensive Agents; Blood Pressure; Coronary Vessels; Cromakalim; Crystallography, X-Ray; Dogs; Female; Hypertension; In Vitro Techniques; Intracranial Pressure; Male; Muscle Contraction; Muscle, Smooth, Vascular; Oxazines; Potassium Channels; Rats; Rats, Inbred SHR; Structure-Activity Relationship | 1999 |
Arterial function in nitric oxide-deficient hypertension: influence of long-term angiotensin II receptor antagonism.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Cromakalim; Cyclooxygenase Inhibitors; Diclofenac; Hypertension; In Vitro Techniques; Isoproterenol; Losartan; Male; Mesenteric Arteries; Muscle, Smooth, Vascular; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Nitroprusside; Rats; Rats, Wistar; Vasodilator Agents | 1999 |
The effects of a newly synthesized ATP-sensitive potassium channel opener, MJ-355, on blood pressure and myocardial ischemia-reperfusion injury in rats.
Topics: Anesthesia; Animals; Anti-Arrhythmia Agents; Antihypertensive Agents; Arrhythmias, Cardiac; ATP-Binding Cassette Transporters; Benzopyrans; Blood Pressure; Cromakalim; Glyburide; Hemodynamics; Hypertension; Hypoglycemic Agents; KATP Channels; Male; Myocardial Infarction; Myocardial Reperfusion Injury; Myocardium; Potassium Channels; Potassium Channels, Inwardly Rectifying; Pyrrolidinones; Rats; Rats, Inbred SHR; Rats, Sprague-Dawley | 1999 |
Renin-angiotensin system blockade improves endothelial dysfunction in hypertension.
Topics: Acetylcholine; Administration, Oral; Angiotensin Receptor Antagonists; Animals; Anti-Inflammatory Agents, Non-Steroidal; Antihypertensive Agents; Benzimidazoles; Biological Factors; Biphenyl Compounds; Cromakalim; Disease Models, Animal; Drug Therapy, Combination; Enalapril; Endothelium, Vascular; Enzyme Inhibitors; Hypertension; In Vitro Techniques; Indomethacin; Male; Nitroarginine; Norepinephrine; Potassium Channels; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Renin-Angiotensin System; Tetrazoles | 2000 |
Impaired beta-adrenergic hyperpolarization in arteries from prehypertensive spontaneously hypertensive rats.
Topics: Animals; Antihypertensive Agents; Cholera Toxin; Colforsin; Cromakalim; Hypertension; Isoproterenol; Membrane Potentials; Mesenteric Arteries; Microelectrodes; Muscle, Smooth, Vascular; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Receptors, Adrenergic, beta; Vascular Resistance | 2001 |
The role of oxygen-derived free radicals in augmented relaxations to levcromakalim in the aorta from hypertensive rats.
Topics: Animals; Aorta; Blood Pressure; Catalase; Cromakalim; Deferoxamine; Dose-Response Relationship, Drug; Free Radical Scavengers; Glyburide; Hydrogen Peroxide; Hypertension; In Vitro Techniques; Male; Muscle Relaxation; Muscle, Smooth, Vascular; Potassium Channels; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Superoxide Dismutase; Vasodilator Agents | 2001 |
Salt-induced hypertension in rats alters the response of isolated aortic rings to cromakalim.
Topics: Adenosine Triphosphatases; Animals; Aorta; Cromakalim; Hypertension; Muscle, Smooth, Vascular; Potassium Channels; Random Allocation; Rats; Rats, Sprague-Dawley; Sodium Chloride, Dietary; Sodium-Potassium-Exchanging ATPase; Treatment Outcome; Vasodilator Agents | 2001 |
Preferential small arteriolar vasodilatation by the potassium channel opener, BRL 38227, in conscious spontaneously hypertensive rats.
Topics: Animals; Arterioles; Benzopyrans; Blood Pressure; Cromakalim; Heart Rate; Hypertension; Male; Potassium Channels; Pyrroles; Rats; Rats, Inbred SHR; Vasodilation; Vasodilator Agents | 1992 |
Differential effects of endothelin-1 on the vasorelaxant properties of benzopyran and non-benzopyran potassium channel openers.
Topics: Animals; Aorta; Benzopyrans; Cromakalim; Cyclopentanes; Dihydropyridines; Dose-Response Relationship, Drug; Endothelins; Guanidines; Hypertension; In Vitro Techniques; Male; Muscle Relaxation; Muscle, Smooth, Vascular; Pinacidil; Potassium Channels; Pyridines; Pyrroles; Rats; Rats, Inbred SHR; Rats, Sprague-Dawley; Vasodilation; Vasodilator Agents | 1992 |
Clinical studies with the potassium channel activator cromakalim in normotensive and hypertensive subjects.
Topics: Adult; Antihypertensive Agents; Atenolol; Benzopyrans; Blood Pressure; Cromakalim; Heart Rate; Humans; Hypertension; Kidney; Liver Circulation; Lung; Male; Potassium Channels; Pyrroles; Renin | 1990 |
[Potassium channel activators. Perspectives in the treatment of arterial hypertension].
Topics: Antihypertensive Agents; Benzopyrans; Cromakalim; Guanidines; Humans; Hypertension; Niacinamide; Nicorandil; Pinacidil; Potassium Channels; Pyrroles | 1991 |
Functional changes in potassium channels in carotid arteries from stroke-prone spontaneously hypertensive rats.
Topics: Animals; Benzopyrans; Carotid Arteries; Cerebrovascular Disorders; Cromakalim; Glyburide; Hypertension; In Vitro Techniques; Male; Muscle, Smooth, Vascular; Norepinephrine; Potassium Channels; Pyrroles; Rats; Rats, Inbred SHR; Rats, Inbred WKY | 1990 |
Variation in the aromatic ring of cromakalim: antihypertensive activity of pyranopyridines and 6-alkyl-2H-1-benzopyrans.
Topics: Animals; Antihypertensive Agents; Benzopyrans; Chemical Phenomena; Chemistry; Cromakalim; Hypertension; Pyrans; Pyridines; Pyrroles; Rats; Rats, Inbred SHR; Structure-Activity Relationship | 1990 |
Effects of cromakalim, a potassium channel opener, on regional blood flow in conscious spontaneously hypertensive rats.
Topics: Animals; Benzopyrans; Blood Pressure; Cromakalim; Heart Rate; Hemodynamics; Humans; Hypertension; Infant, Newborn; Microspheres; Nifedipine; Pyrroles; Rats; Rats, Inbred SHR; Regional Blood Flow; Vascular Resistance | 1990 |
Short-term monotherapy with the potassium channel activator BRL 34915 on endocrine sodium regulation in essential hypertension.
Topics: Administration, Oral; Adult; Aldosterone; Atrial Natriuretic Factor; Benzopyrans; Blood Pressure; Cromakalim; Female; Heart Rate; Humans; Hypertension; Male; Middle Aged; Pyrroles; Renin; Renin-Angiotensin System; Sodium | 1989 |
Pharmacokinetics of cromakalim--a new antihypertensive agent, in patients with mild essential hypertension.
Topics: Adult; Aged; Antihypertensive Agents; Benzopyrans; Cromakalim; Dose-Response Relationship, Drug; Female; Half-Life; Humans; Hypertension; Male; Middle Aged; Pyrroles | 1989 |
Increased vasodilator responsiveness to BRL 34915 in spontaneously hypertensive versus normotensive rats: contrast with nifedipine.
Topics: Animals; Antihypertensive Agents; Aorta; Benzopyrans; Blood Pressure; Cromakalim; Dose-Response Relationship, Drug; Heart Rate; Hypertension; Male; Muscle Relaxation; Muscle, Smooth, Vascular; Nifedipine; Phenylephrine; Pyrroles; Rats; Rats, Inbred SHR; Vascular Resistance; Vasodilation | 1989 |
Studies on the anti-vasoconstrictor activity of BRL 34915 in spontaneously hypertensive rats; a comparison with nifedipine.
Topics: Angiotensin II; Animals; Benzopyrans; Blood Pressure; Cromakalim; Dose-Response Relationship, Drug; Female; Hypertension; Infusions, Intravenous; Nifedipine; Norepinephrine; Phenylephrine; Pyrroles; Rats; Rats, Inbred SHR; Vasoconstriction; Vasopressins | 1988 |