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cromakalim and Heart Disease, Ischemic

cromakalim has been researched along with Heart Disease, Ischemic in 56 studies

Research

Studies (56)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	46 (82.14)	18.2507
2000's	9 (16.07)	29.6817
2010's	1 (1.79)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Carroll, WA; Coghlan, MJ; Gopalakrishnan, M	1
Gao, JY; Ito, K; Ito, Y; Shimokawa, H; Shiroto, T; Tsuburaya, R; Yasuda, S	1
Curtis, MJ; Hearse, DJ; Rees, SA; Tsuchihashi, K	1
Kinoshita, M; Nakae, I; Quan, L; Sugimoto, Y; Tsutamoto, T	1
Grover, GJ; Speechly-Dick, ME; Yellon, DM	1
Abe, T; Arita, M; Saikawa, T; Sakata, T; Sato, T; Shigematsu, S	1
D'Alonzo, AJ; Darbenzio, RB; Grover, GJ; Parham, CS	2
Atwal, KS; D'Alonzo, AJ; Grover, GJ; McCullough, JR; Sargent, CA	1
Dux, L; Ferdinandy, P; Koltai, M; Szilvássy, Z	1
Grover, GJ	2
D'Alonzo, AJ; Darbenzio, RB; Grover, GJ; Hess, TA; Sewter, JC; Sleph, PG	1
Moore, TL; Shebuski, RJ; Toombs, CF	1
Armstrong, JM; Bellemin-Baurreau, J; Hicks, PE; Poizot, A; Rochette, L	1
Hellwig, B	1
Cavero, I; Premmereur, J	1
Allard, M; Braquet, PG; Ferdinandy, P; Jakab, I; Koltai, M; Lonovics, J; Szilvassy, Z; Tarrade, T	1
Ahmed, SZ; Atwal, KS; Dzwonczyk, S; Ferrara, FN; Grover, GJ; Harper, TW; Kim, KS; Moreland, S; Russell, AD; Sleph, PG	1
Das, DK; Engelman, RM; Szerdahelyi, P; Tosaki, A	1
Nakaya, H	1
Harada, K; Jinno, Y; Miwa, A; Nakazawa, H; Nishikori, K; Ogawa, N; Ohta, H	1
Das, DK; Engelman, DT; Engelman, RM; Tosaki, A	1
D'Alonzo, AJ; Darbenzio, RB; Grover, GJ; Hess, T; Sleph, PG	1
Droy-Lefaix, MT; Ferdinandy, P; Koltai, M; Szilvássy, Z; Tarrade, T	1
Grover, GJ; Sleph, PG	1
Baird, AJ; Grover, GJ; Sleph, PG	1
Dzwonczyk, S; Grover, GJ; Monticello, TM	1
D'Alonzo, AJ; Darbenzio, RB; Grover, GJ; Hess, TA; Lodge, NJ; Normandin, DE; Sewter, JC; Sleph, PG	1
Das, DK; Engelman, RM; Tosaki, A	1
Chujo, M; Hori, M; Inoue, M; Kamada, T; Kitakaze, M; Komamura, K; Minamino, T; Mori, H; Node, K; Shinozaki, Y	1
Escande, D; Henry, P; Hinescu, ME; Popescu, A; Pucéat, M	1
Fleck, E; Henning, B; Hildebrandt, AG; Ott, T; Zünkler, BJ	1
Deslauriers, R; Docherty, JC; Gunter, HE; Kuzio, B; Shoemaker, L; Yang, L	1
Das, DK; Tosaki, A	1
György, K; Kaszala, K; Papp, JG; Parratt, JR; Vegh, A	1
Deutsch, NA; Goldhaber, JI; Khuu, K; Lamp, ST; Shivkumar, K; Weiss, JN	1
Cho, TS; Jung, YS; Moon, CH; Shin, HS; Yoo, SE	1
Ashraf, M; Miyawaki, H; Wang, Y	1
Kamei, K; Kamijo, T; Kamiyama, T; Ohba, Y; Sudo, H; Sugo, I	1
Cobbe, SM; Hicks, MN; Kane, KA; Wolk, R	1
Chang, MJ; Chen, YC; Cheng, CY; Lee, YM; Peng, YY; Sheu, JR; Yen, MH	1
Obata, T; Yamanaka, Y	1
Avkiran, M; Coetzee, WA; Wells, T	1
Ismail, JA; McDonough, KH	1
Atwal, KS; Bajgar, R; D'Alonzo, AJ; Darbenzio, RB; Garlid, KD; Grover, GJ; Hess, TA; Lodge, NJ; Paucek, P; Sleph, PG; Smith, MA	1
Coronel, R; de Groot, JR; de Jong, JW; Fiolet, JW; Remme, CA; Schumacher, CA; Wilde, AA	1
de Hemptinne, A; Vanheel, B	1
Galiñanes, M; Hearse, DJ; Shattock, MJ	1
Wilde, AA	1
Alexander, LD; Lamp, ST; Stuart, JS; Venkatesh, N; Weiss, JN	1
Ahmed, SZ; Atwal, KS; Baird, AJ; Dzwonczyk, S; Grover, GJ; Normandin, DE; Sleph, PG	1
Ahmed, SZ; Atwal, KS; Dzwonczyk, S; Ferrara, FN; Grover, GJ; Normandin, DE; Sleph, PG	1
Ahmed, SZ; Atwal, KS; Ding, CZ; Grover, GJ; Kelly, Y; Miller, AV; Misra, RN; Normandin, DE; Rovnyak, GC; Sleph, PG	1
Balsamo, A; Breschi, MC; Calderone, V; Digiacomo, M; Manganaro, M; Martelli, A; Minutolo, F; Rapposelli, S; Testai, L; Tonelli, F	1
Calderone, V; Cirilli, R; Digiacomo, M; Faggi, C; La Torre, F; Manganaro, M; Martelli, A; Rapposelli, S; Testai, L	1

Reviews

5 review(s) available for cromakalim and Heart Disease, Ischemic

Article	Year
Recent developments in the biology and medicinal chemistry of potassium channel modulators: update from a decade of progress. Journal of medicinal chemistry, 2001, May-24, Volume: 44, Issue:11 Topics: Adenosine Triphosphate; Angina Pectoris; Arrhythmias, Cardiac; Asthma; Calcium; Ion Channel Gating; Myocardial Ischemia; Potassium Channel Blockers; Potassium Channels; Urinary Incontinence	2001
Protective effects of ATP-sensitive potassium-channel openers in experimental myocardial ischemia. Journal of cardiovascular pharmacology, 1994, Volume: 24 Suppl 4 Topics: Action Potentials; Adenosine Triphosphate; Animals; Benzopyrans; Cromakalim; Dihydropyridines; Disease Models, Animal; Dogs; Guanidines; Guinea Pigs; Myocardial Contraction; Myocardial Infarction; Myocardial Ischemia; Picolines; Pinacidil; Potassium Channels; Pyrans; Pyrroles; Rats; Vasodilator Agents	1994
[Potassium agonists]. Medizinische Monatsschrift fur Pharmazeuten, 1994, Volume: 17, Issue:6 Topics: Animals; Benzopyrans; Calcium; Cromakalim; Humans; Membrane Potentials; Muscle, Smooth, Vascular; Myocardial Ischemia; Neuromuscular Junction; Niacinamide; Nicorandil; Potassium; Potassium Channels; Pyrroles; Vascular Resistance; Vasodilator Agents	1994
[Potential role of ATP-sensitive K+ channels in ischemia- and reperfusion-induced arrhythmias]. Kokyu to junkan. Respiration & circulation, 1993, Volume: 41, Issue:6 Topics: Action Potentials; Adenosine Triphosphate; Animals; Arrhythmias, Cardiac; Benzopyrans; Cromakalim; Glyburide; Guanidines; Humans; Myocardial Ischemia; Myocardial Reperfusion Injury; Myocardium; Niacinamide; Nicorandil; Pinacidil; Potassium; Potassium Channels; Pyrroles; Tolbutamide	1993
Pharmacology of ATP-sensitive potassium channel (KATP) openers in models of myocardial ischemia and reperfusion. Canadian journal of physiology and pharmacology, 1997, Volume: 75, Issue:4 Topics: Animals; ATP-Binding Cassette Transporters; Benzopyrans; Cromakalim; Guanidines; Humans; Ischemic Preconditioning, Myocardial; KATP Channels; Mitochondria, Heart; Models, Cardiovascular; Myocardial Ischemia; Myocardial Reperfusion; Niacinamide; Nicorandil; Picolines; Pinacidil; Potassium Channels; Potassium Channels, Inwardly Rectifying; Pyrans; Pyrroles; Rats	1997

Other Studies

51 other study(ies) available for cromakalim and Heart Disease, Ischemic

Article	Year
Eicosapentaenoic acid reduces ischemic ventricular fibrillation via altering monophasic action potential in pigs. Journal of molecular and cellular cardiology, 2011, Volume: 51, Issue:3 Topics: Action Potentials; Animals; Anti-Arrhythmia Agents; Cromakalim; Disease Models, Animal; Eicosapentaenoic Acid; Fatty Acids; Gene Expression Regulation; Male; Myocardial Ischemia; Parasympatholytics; Potassium Channels, Inwardly Rectifying; Swine; Ventricular Fibrillation	2011
Combined administration of an IK(ATP) activator and Ito blocker increases coronary flow independently of effects on heart rate, QT interval, and ischaemia-induced ventricular fibrillation in rats. Journal of cardiovascular pharmacology, 1993, Volume: 22, Issue:3 Topics: Animals; Anti-Arrhythmia Agents; Benzopyrans; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Coronary Circulation; Cromakalim; Cyclopropanes; Drug Synergism; Drug Therapy, Combination; Electrocardiography; Heart Rate; Hemodynamics; In Vitro Techniques; Injections, Intravenous; Male; Myocardial Ischemia; Potassium Channels; Pyrroles; Rats; Rats, Wistar; Vasodilator Agents; Ventricular Fibrillation	1993
Glibenclamide-induced oscillation of canine coronary artery is independent of myocardial ischemia. Journal of cardiovascular pharmacology, 1994, Volume: 23, Issue:3 Topics: Adenosine Triphosphate; Animals; Arginine; Benzopyrans; Coronary Circulation; Coronary Vessels; Cromakalim; Diltiazem; Dogs; Female; Glyburide; In Vitro Techniques; Male; Muscle Tonus; Muscle, Smooth, Vascular; Myocardial Ischemia; Niacinamide; Nicorandil; Nitroarginine; Nitroglycerin; Potassium Channels; Pyrroles; Vasodilator Agents	1994
Does ischemic preconditioning in the human involve protein kinase C and the ATP-dependent K+ channel? Studies of contractile function after simulated ischemia in an atrial in vitro model. Circulation research, 1995, Volume: 77, Issue:5 Topics: Adenosine Triphosphate; Adult; Aged; Alkaloids; Benzophenanthridines; Benzopyrans; Cromakalim; Diglycerides; Female; Heart Atria; Humans; In Vitro Techniques; Male; Middle Aged; Myocardial Contraction; Myocardial Ischemia; Myocardial Reperfusion; Phenanthridines; Potassium Channels; Protein Kinase C; Pyrroles; Random Allocation; Time Factors	1995
Pharmacological evidence for the persistent activation of ATP-sensitive K+ channels in early phase of reperfusion and its protective role against myocardial stunning. Circulation, 1995, Oct-15, Volume: 92, Issue:8 Topics: Action Potentials; Adenosine Triphosphate; Animals; Arrhythmias, Cardiac; Benzopyrans; Cromakalim; Glyburide; Guinea Pigs; Male; Myocardial Contraction; Myocardial Ischemia; Myocardial Reperfusion; Myocardial Reperfusion Injury; Myocardial Stunning; Myocardium; Perfusion; Potassium Channels; Pyrroles	1995
Cardioprotection with the KATP opener cromakalim is not correlated with ischemic myocardial action potential duration. Journal of cardiovascular pharmacology, 1995, Volume: 26, Issue:1 Topics: Action Potentials; Adenosine Triphosphate; Animals; Anti-Arrhythmia Agents; Benzopyrans; Cromakalim; Dogs; Dose-Response Relationship, Drug; Drug Therapy, Combination; Female; Infusions, Intravenous; Male; Myocardial Ischemia; Myocardial Reperfusion Injury; Phenethylamines; Potassium Channels; Pyrroles; Regional Blood Flow; Sulfonamides	1995
Cardioprotective profile of the cardiac-selective ATP-sensitive potassium channel opener BMS-180448. Journal of cardiovascular pharmacology, 1995, Volume: 25, Issue:1 Topics: Adenosine Triphosphate; Animals; Anti-Arrhythmia Agents; Aorta; Benzopyrans; Cromakalim; Decanoic Acids; Dogs; Female; Glyburide; Guanidines; Guinea Pigs; Heart; Heart Ventricles; Hydroxy Acids; In Vitro Techniques; Injections, Intravenous; Injections, Subcutaneous; Male; Muscle Contraction; Muscle Relaxation; Muscle, Smooth, Vascular; Myocardial Ischemia; Potassium Channels; Pyrroles; Rats; Rats, Sprague-Dawley; Vasodilator Agents	1995
Ventricular overdrive pacing-induced preconditioning and no-flow ischemia-induced preconditioning in isolated working rat hearts. Journal of cardiovascular pharmacology, 1995, Volume: 25, Issue:1 Topics: Animals; Benzopyrans; Blood Pressure; Cardiac Pacing, Artificial; Coronary Circulation; Cromakalim; Disease Models, Animal; Glyburide; Heart; In Vitro Techniques; Male; Myocardial Ischemia; Myocardial Reperfusion; Myocardial Reperfusion Injury; Potassium Channels; Pyrroles; Rats; Rats, Wistar; Vasodilator Agents	1995
Effect of potassium on the action of the KATP modulators cromakalim, pinacidil, or glibenclamide on arrhythmias in isolated perfused rat heart subjected to regional ischaemia. Cardiovascular research, 1994, Volume: 28, Issue:6 Topics: Animals; Arrhythmias, Cardiac; Benzopyrans; Cromakalim; Glyburide; Guanidines; Heart; Heart Rate; Myocardial Ischemia; Myocardial Reperfusion Injury; Perfusion; Pinacidil; Potassium; Pyrroles; Rats; Rats, Sprague-Dawley; Vasodilator Agents	1994
Cardioprotection with U-89232 is not reversible with glibenclamide: evidence of a novel anti-ischemic agent derived from cromakalim. Pharmacology, 1994, Volume: 49, Issue:2 Topics: Animals; Benzopyrans; Cromakalim; Female; Glyburide; Guanidines; Heart; Hemodynamics; Male; Myocardial Ischemia; Myocardial Reperfusion Injury; Myocardium; Necrosis; Potassium Channels; Pyrroles; Rabbits; Vasodilator Agents	1994
Effects of ATP-dependent K+ channel modulators on an ischemia-reperfusion rabbit isolated heart model with programmed electrical stimulation. European journal of pharmacology, 1994, Apr-21, Volume: 256, Issue:2 Topics: Adenosine Triphosphate; Animals; Arrhythmias, Cardiac; Benzopyrans; Blood Pressure; Coronary Circulation; Cromakalim; Electric Stimulation; Glyburide; Heart; In Vitro Techniques; Myocardial Ischemia; Myocardial Reperfusion Injury; Potassium Channels; Pyrroles; Rabbits; Refractory Period, Electrophysiological; Vasodilator Agents	1994
ATP sensitive potassium channel openers are of potential benefit in ischaemic heart disease. Cardiovascular research, 1994, Volume: 28, Issue:1 Topics: Benzopyrans; Cromakalim; Dihydropyridines; Guanidines; Humans; Myocardial Ischemia; Myocardium; Niacinamide; Nicorandil; Picolines; Pinacidil; Potassium Channels; Pyrans; Pyrroles; Sodium-Potassium-Exchanging ATPase; Vasodilator Agents	1994
Cromakalim and cicletanine against pacing-induced myocardial ischemia in conscious rabbits. Life sciences, 1994, Volume: 54, Issue:9 Topics: Animals; Antihypertensive Agents; Benzopyrans; Blood Pressure; Cardiac Pacing, Artificial; Consciousness; Cromakalim; Heart Rate; Male; Myocardial Ischemia; Potassium Channels; Pyridines; Pyrroles; Rabbits; Stroke Volume; Vasodilator Agents; Ventricular Function, Left	1994
Cardioselective anti-ischemic ATP-sensitive potassium channel openers. Journal of medicinal chemistry, 1993, Nov-26, Volume: 36, Issue:24 Topics: Adenosine Triphosphate; Animals; Aorta; Benzopyrans; Biological Availability; Cocaine; Cromakalim; Guanidines; Ion Channel Gating; Molecular Structure; Myocardial Ischemia; Potassium Channels; Pyrroles; Rats; Structure-Activity Relationship; Vasodilation	1993
Potassium channel openers and blockers: do they possess proarrhythmic or antiarrhythmic activity in ischemic and reperfused rat hearts? The Journal of pharmacology and experimental therapeutics, 1993, Volume: 267, Issue:3 Topics: Animals; Anti-Arrhythmia Agents; Antihypertensive Agents; Arrhythmias, Cardiac; Benzopyrans; Cations; Cromakalim; Glyburide; Heart; Ion Channel Gating; Male; Myocardial Ischemia; Myocardial Reperfusion Injury; Potassium Channels; Pyrroles; Rats; Rats, Sprague-Dawley	1993
Effects of K+ channel openers on ischemic dysfunction and metabolic disturbance in isolated perfused rat heart. European journal of pharmacology, 1993, Feb-16, Volume: 231, Issue:3 Topics: Animals; Benzopyrans; Cromakalim; Heart; Hemodynamics; Male; Myocardial Ischemia; Myocardial Reperfusion; Pyridines; Pyrroles; Rats; Rats, Wistar; Vasodilator Agents	1993
Diabetes and ATP-sensitive potassium channel openers and blockers in isolated ischemic/reperfused hearts. The Journal of pharmacology and experimental therapeutics, 1995, Volume: 275, Issue:3 Topics: Adenosine Triphosphate; Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Benzopyrans; Cations; Cromakalim; Diabetes Mellitus, Experimental; Glyburide; Heart Function Tests; Hypoglycemic Agents; In Vitro Techniques; Male; Myocardial Ischemia; Myocardial Reperfusion; Myocardium; Potassium Channel Blockers; Potassium Channels; Pyrroles; Rats; Rats, Sprague-Dawley; Streptozocin	1995
Glyburide-reversible cardioprotective effect of BMS-180448 is independent of action potential shortening. Cardiovascular research, 1995, Volume: 30, Issue:5 Topics: Action Potentials; Adenosine Triphosphate; Animals; Benzopyrans; Cromakalim; Female; Glyburide; Guanidines; Guinea Pigs; In Vitro Techniques; Ion Channel Gating; Male; Membrane Potentials; Myocardial Infarction; Myocardial Ischemia; Perfusion; Potassium Channels; Pyrroles; Vasodilator Agents	1995
KATP channel modulation in working rat hearts with coronary occlusion: effects of cromakalim, cicletanine, and glibenclamide. Cardiovascular research, 1995, Volume: 30, Issue:5 Topics: Animals; Anti-Arrhythmia Agents; Benzopyrans; Coronary Circulation; Coronary Disease; Cromakalim; Glyburide; Heart; Ion Channel Gating; Male; Myocardial Ischemia; Myocardial Reperfusion Injury; Potassium Channels; Pyridines; Pyrroles; Rats; Rats, Wistar; Ventricular Fibrillation	1995
Protective effect of K(ATP) openers in ischemic rat hearts treated with a potassium cardioplegic solution. Journal of cardiovascular pharmacology, 1995, Volume: 26, Issue:5 Topics: Adenosine Triphosphate; Animals; Benzopyrans; Cardioplegic Solutions; Cromakalim; Guanidines; Heart; Male; Myocardial Ischemia; Potassium Channels; Pyrroles; Rats; Rats, Sprague-Dawley	1995
Lack of a pharmacologic interaction between ATP-sensitive potassium channels and adenosine A1 receptors in ischemic rat hearts. Cardiovascular research, 1996, Volume: 31, Issue:4 Topics: Adenosine Triphosphate; Animals; Benzopyrans; Cromakalim; Dose-Response Relationship, Drug; Glyburide; Male; Myocardial Ischemia; Myocardium; Perfusion; Phenylisopropyladenosine; Potassium Channels; Purinergic P1 Receptor Agonists; Purinergic P1 Receptor Antagonists; Pyrroles; Rats; Rats, Sprague-Dawley; Receptors, Purinergic P1; Xanthines	1996
Comparative cardioprotective effects of cromakalim and diltiazem in ischemic hypertrophied rat hearts. The American journal of physiology, 1996, Volume: 270, Issue:1 Pt 2 Topics: Animals; Benzopyrans; Blood Pressure; Cardiomegaly; Cromakalim; Diltiazem; Heart; Heart Rate; L-Lactate Dehydrogenase; Male; Myocardial Contraction; Myocardial Ischemia; Myocardial Reperfusion Injury; Myocardium; Pyrroles; Rats; Rats, Inbred WKY; Rats, Sprague-Dawley; Ventricular Function, Left	1996
A comparison between the effects of BMS-180448, a novel K+ channel opener, and cromakalim in rat and dog. European journal of pharmacology, 1995, Dec-27, Volume: 294, Issue:1 Topics: Animals; Anti-Arrhythmia Agents; Aorta, Thoracic; Benzopyrans; Blood Pressure; Cardiotonic Agents; Cromakalim; Dogs; Electrophysiology; Guanidines; Heart; Heart Conduction System; Heart Rate; In Vitro Techniques; Male; Muscle, Smooth, Vascular; Myocardial Ischemia; Potassium Channels; Pyrroles; Rats; Rats, Inbred WKY; Rats, Sprague-Dawley; Refractory Period, Electrophysiological; Species Specificity	1995
Effects of cromakalim and glibenclamide in ischemic and reperfused hearts. Annals of the New York Academy of Sciences, 1996, Sep-30, Volume: 793 Topics: Animals; Anti-Arrhythmia Agents; Benzopyrans; Cromakalim; Diabetes Mellitus, Experimental; Glyburide; In Vitro Techniques; Male; Myocardial Contraction; Myocardial Ischemia; Myocardial Reperfusion Injury; Pyrroles; Rats; Rats, Sprague-Dawley	1996
Role of activation of ectosolic 5'-nucleotidase in the cardioprotection mediated by opening of K+c channels. The American journal of physiology, 1996, Volume: 270, Issue:5 Pt 2 Topics: 5'-Nucleotidase; Adenosine Triphosphate; Animals; Benzopyrans; Cromakalim; Dogs; Enzyme Activation; Glyburide; Heart; Hemodynamics; Myocardial Infarction; Myocardial Ischemia; Myocardial Reperfusion; Myocardium; Niacinamide; Nicorandil; Potassium Channels; Pyrroles; Recurrence	1996
Acute simulated ischaemia produces both inhibition and activation of K+ currents in isolated ventricular myocytes. Cardiovascular research, 1996, Volume: 32, Issue:5 Topics: Action Potentials; Animals; Benzopyrans; Cromakalim; Hydrogen-Ion Concentration; Ischemic Preconditioning, Myocardial; Myocardial Ischemia; Myocardium; Patch-Clamp Techniques; Potassium Channels; Pyrroles; Rats; Sodium-Potassium-Exchanging ATPase	1996
Effects of tolbutamide on ATP-sensitive K+ channels from human right atrial cardiac myocytes. Pharmacology & toxicology, 1997, Volume: 80, Issue:2 Topics: Adenosine Triphosphate; Adolescent; Adult; Aged; Atrial Function, Right; Benzopyrans; Child; Cromakalim; Drug Interactions; Female; Heart Atria; Humans; Hypoglycemic Agents; Kinetics; Male; Membrane Potentials; Middle Aged; Myocardial Ischemia; Myocardium; Potassium Channels; Pyrroles; Sensitivity and Specificity; Tolbutamide	1997
Effects of cromakalim and glibenclamide on myocardial high energy phosphates and intracellular pH during ischemia-reperfusion: 31P NMR studies. Journal of molecular and cellular cardiology, 1997, Volume: 29, Issue:6 Topics: Adenosine Triphosphate; Animals; Anti-Arrhythmia Agents; Benzopyrans; Coronary Circulation; Cromakalim; Decanoic Acids; Dose-Response Relationship, Drug; Glyburide; Hydrogen-Ion Concentration; Hydroxy Acids; Hypoglycemic Agents; In Vitro Techniques; Lactates; Magnetic Resonance Spectroscopy; Male; Myocardial Ischemia; Myocardial Reperfusion; Myocardium; Phosphorus Isotopes; Pyrroles; Rats; Rats, Sprague-Dawley	1997
Extracellular Mg++ manipulation prevents the proarrhythmic activity of cromakalim in ischemic/reperfused diabetic hearts. The Journal of pharmacology and experimental therapeutics, 1997, Volume: 282, Issue:1 Topics: Animals; Arrhythmias, Cardiac; Benzopyrans; Calcium; Cromakalim; Diabetes Mellitus, Experimental; Heart; Magnesium; Male; Myocardial Ischemia; Myocardial Reperfusion; Potassium Channels; Pyrroles; Rats; Rats, Sprague-Dawley; Sodium; Streptozocin	1997
Does the opening of ATP-sensitive K+ channels modify ischaemia-induced ventricular arrhythmias in anaesthetised dogs? European journal of pharmacology, 1997, Aug-20, Volume: 333, Issue:1 Topics: Adenosine Triphosphate; Anesthesia; Animals; Arrhythmias, Cardiac; Coronary Circulation; Cromakalim; Dogs; Female; Hemodynamics; Male; Myocardial Ischemia; Myocardial Reperfusion Injury; Potassium Channels; Vasodilator Agents	1997
Mechanism of hypoxic K loss in rabbit ventricle. The Journal of clinical investigation, 1997, Oct-01, Volume: 100, Issue:7 Topics: Action Potentials; Animals; Arrhythmias, Cardiac; Biological Transport; Cromakalim; Glyburide; Heart Ventricles; Hypoxia; In Vitro Techniques; Ion Channel Gating; Male; Models, Biological; Myocardial Ischemia; Potassium; Potassium Channel Blockers; Potassium Channels; Rabbits; Sodium	1997
Cardioprotective effects of KR-30450, a novel K+(ATP) opener, and its major metabolite KR-30818 on isolated rat hearts. Japanese journal of pharmacology, 1998, Volume: 76, Issue:1 Topics: Animals; Antihypertensive Agents; Benzopyrans; Cromakalim; Dose-Response Relationship, Drug; Glyburide; Heart; Heart Rate; Hypoglycemic Agents; In Vitro Techniques; L-Lactate Dehydrogenase; Male; Myocardial Contraction; Myocardial Ischemia; Myocardial Reperfusion Injury; Potassium Channel Blockers; Potassium Channels; Pyrimidines; Pyrrolidinones; Rats; Rats, Sprague-Dawley; Regional Blood Flow; Vasodilator Agents	1998
Oxidant stress with hydrogen peroxide attenuates calcium paradox injury: role of protein kinase C and ATP-sensitive potassium channel. Cardiovascular research, 1998, Volume: 37, Issue:3 Topics: Adenosine Triphosphate; Alkaloids; Animals; Anti-Arrhythmia Agents; Benzophenanthridines; Calcium; Cromakalim; Enzyme Inhibitors; Glyburide; Hemodynamics; Hydrogen Peroxide; L-Lactate Dehydrogenase; Male; Myocardial Ischemia; Myocardium; Perfusion; Phenanthridines; Potassium Channel Blockers; Potassium Channels; Protein Kinase C; Rats; Rats, Sprague-Dawley; Tetradecanoylphorbol Acetate	1998
Hemodynamic and hormonal responses to nicorandil in a canine model of acute ischemic heart failure: a comparison with cromakalim and nitroglycerin. Journal of cardiovascular pharmacology, 1999, Volume: 33, Issue:1 Topics: Acute Disease; Animals; Atrial Natriuretic Factor; Cardiac Output, Low; Cromakalim; Dogs; Embolization, Therapeutic; Female; Hemodynamics; Hormones; Male; Microspheres; Myocardial Ischemia; Natriuretic Peptide, Brain; Nicorandil; Nitroglycerin; Potassium Channels; Renin; Vasodilator Agents	1999
Relevance of inter- and intraventricular electrical dispersion to arrhythmogenesis in normal and ischaemic rabbit myocardium: a study with cromakalim, 5-hydroxydecanoate and glibenclamide. Journal of cardiovascular pharmacology, 1999, Volume: 33, Issue:2 Topics: Action Potentials; Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Coronary Disease; Cromakalim; Decanoic Acids; Glyburide; Heart; Hydroxy Acids; In Vitro Techniques; Male; Myocardial Ischemia; Potassium Channels; Rabbits; Refractory Period, Electrophysiological; Ventricular Fibrillation	1999
The antihypertensive and cardioprotective effects of (-)-MJ-451, an ATP-sensitive K(+) channel opener. European journal of pharmacology, 2000, May-26, Volume: 397, Issue:1 Topics: Adenosine Triphosphate; Animals; Antihypertensive Agents; Aorta, Thoracic; Arrhythmias, Cardiac; Benzopyrans; Blood Pressure; Cromakalim; Dose-Response Relationship, Drug; Heart; Heart Rate; Hemodynamics; In Vitro Techniques; Male; Myocardial Ischemia; Myocardial Reperfusion Injury; Potassium Channels; Pyrrolidinones; Rats; Rats, Inbred SHR; Rats, Sprague-Dawley; Rats, Wistar; Vasodilation; Vasodilator Agents; Ventricular Fibrillation	2000
Block of cardiac ATP-sensitive K(+) channels reduces hydroxyl radicals in the rat myocardium. Archives of biochemistry and biophysics, 2000, Jun-15, Volume: 378, Issue:2 Topics: Adenosine Triphosphate; Animals; Anti-Arrhythmia Agents; Antihypertensive Agents; Cromakalim; Decanoic Acids; Dose-Response Relationship, Drug; Ferrous Compounds; Glyburide; Hydroxy Acids; Hydroxybenzoates; Hydroxyl Radical; Hypoglycemic Agents; Inhibitory Concentration 50; Iron Chelating Agents; Male; Microdialysis; Myocardial Ischemia; Myocardium; Nicorandil; Potassium Channel Blockers; Rats; Rats, Wistar; Salicylates; Time Factors	2000
Anti-arrhythmic effects of levcromakalim in the ischaemic rat heart: a dual mechanism of action? European journal of pharmacology, 2000, Aug-25, Volume: 402, Issue:3 Topics: Adenosine Triphosphate; Animals; Anti-Arrhythmia Agents; ATP-Binding Cassette Transporters; Coronary Circulation; Cromakalim; Heart Rate; In Vitro Techniques; KATP Channels; Male; Myocardial Ischemia; NADP; Phosphocreatine; Potassium Channels; Potassium Channels, Inwardly Rectifying; Rats; Rats, Wistar	2000
The role of K+ATP channels in the control of pre- and post-ischemic left ventricular developed pressure in septic rat hearts. Canadian journal of physiology and pharmacology, 2001, Volume: 79, Issue:3 Topics: Animals; ATP-Binding Cassette Transporters; Blood Pressure; Coronary Circulation; Cromakalim; Escherichia coli Infections; Glyburide; Hypoglycemic Agents; KATP Channels; Myocardial Contraction; Myocardial Ischemia; Potassium Channel Blockers; Potassium Channels; Potassium Channels, Inwardly Rectifying; Rats; Rats, Sprague-Dawley; Sepsis; Stroke Volume; Vasodilator Agents; Ventricular Function, Left	2001
Pharmacologic characterization of BMS-191095, a mitochondrial K(ATP) opener with no peripheral vasodilator or cardiac action potential shortening activity. The Journal of pharmacology and experimental therapeutics, 2001, Volume: 297, Issue:3 Topics: Action Potentials; Animals; Benzopyrans; Cardiovascular Agents; Cromakalim; Decanoic Acids; Dose-Response Relationship, Drug; Glyburide; Guanidines; Guinea Pigs; Heart; Heart Conduction System; Hydroxy Acids; Imidazoles; In Vitro Techniques; Male; Mitochondria; Myocardial Ischemia; Myocardial Reperfusion; Papillary Muscles; Patch-Clamp Techniques; Potassium; Potassium Channels; Rats; Rats, Sprague-Dawley; Vasodilator Agents; Vasomotor System	2001
K(ATP) channel opening during ischemia: effects on myocardial noradrenaline release and ventricular arrhythmias. Journal of cardiovascular pharmacology, 2001, Volume: 38, Issue:3 Topics: Adenosine Triphosphate; Animals; Arrhythmias, Cardiac; Coronary Circulation; Cromakalim; Female; Glyburide; Heart; Heart Ventricles; Hypoglycemic Agents; In Vitro Techniques; Male; Myocardial Ischemia; Myocardium; Norepinephrine; Potassium; Potassium Channels; Rabbits; Time Factors; Vasodilator Agents	2001
Influence of KATP channel modulation on net potassium efflux from ischaemic mammalian cardiac tissue. Cardiovascular research, 1992, Volume: 26, Issue:11 Topics: Action Potentials; Animals; Barium; Benzopyrans; Cromakalim; Glyburide; Guinea Pigs; Hydrogen-Ion Concentration; Muscles; Myocardial Ischemia; Oxygen; Papillary Muscles; Potassium; Potassium Channels; Pyrroles; Tolbutamide; Vasodilator Agents	1992
Effects of intracoronary cromakalim on postischaemic contractile function and action potential duration. Cardiovascular research, 1992, Volume: 26, Issue:11 Topics: Action Potentials; Animals; Benzopyrans; Blood Pressure; Coronary Circulation; Coronary Vessels; Cromakalim; Dogs; Glyburide; Myocardial Contraction; Myocardial Ischemia; Pyrroles; Vasodilator Agents	1992
Effects of potassium channel modulation during global ischaemia in isolated rat heart with and without cardioplegia. Cardiovascular research, 1992, Volume: 26, Issue:11 Topics: Animals; Benzopyrans; Blood Pressure; Coronary Circulation; Coronary Vessels; Cromakalim; Glyburide; Heart Arrest, Induced; Myocardial Contraction; Myocardial Ischemia; Potassium Channels; Pyrroles; Rats; Rats, Wistar; Vasodilator Agents	1992
KATP channel opening and cardioprotection. Cardiovascular research, 1992, Volume: 26, Issue:11 Topics: Benzopyrans; Cromakalim; Humans; Myocardial Ischemia; Potassium Channels; Pyrroles; Vasodilator Agents	1992
Activation of ATP-sensitive K+ channels by cromakalim. Effects on cellular K+ loss and cardiac function in ischemic and reperfused mammalian ventricle. Circulation research, 1992, Volume: 71, Issue:6 Topics: Action Potentials; Adenosine Triphosphate; Animals; Benzopyrans; Cromakalim; Female; Heart; Heart Ventricles; In Vitro Techniques; Male; Myocardial Contraction; Myocardial Ischemia; Myocardial Reperfusion; Myocardium; Parasympatholytics; Potassium; Potassium Channels; Pyrroles; Rabbits; Vasodilator Agents	1992
Cardioselective anti-ischemic ATP-sensitive potassium channel openers. 3. Structure-activity studies on benzopyranyl cyanoguanidines: modification of the cyanoguanidine portion. Journal of medicinal chemistry, 1995, Aug-18, Volume: 38, Issue:17 Topics: Adenosine Triphosphate; Animals; Guanidines; In Vitro Techniques; Magnetic Resonance Spectroscopy; Myocardial Ischemia; Potassium Channels; Rats; Structure-Activity Relationship; Vasodilator Agents	1995
Cardioselective antiischemic ATP-sensitive potassium channel openers. 2. Structure-activity studies on benzopyranylcyanoguanidines: modification of the benzopyran ring. Journal of medicinal chemistry, 1995, May-26, Volume: 38, Issue:11 Topics: Adenosine Triphosphate; Animals; Aorta; Benzopyrans; Guanidines; Heart; Ion Channel Gating; Male; Muscle Contraction; Muscle Relaxation; Muscle, Smooth, Vascular; Myocardial Ischemia; Potassium Channels; Rats; Rats, Inbred WKY; Rats, Sprague-Dawley; Sensitivity and Specificity; Structure-Activity Relationship	1995
Cardioselective antiischemic ATP-sensitive potassium channel (K(ATP)) openers. 6. Effect of modifications at C6 of benzopyranyl cyanoguanidines. Journal of medicinal chemistry, 1999, Sep-09, Volume: 42, Issue:18 Topics: Animals; Benzopyrans; Cardiotonic Agents; Glyburide; Guanidines; Heart; Muscle Contraction; Myocardial Ischemia; Potassium Channels; Rats; Vasodilation; Vasodilator Agents	1999
Spirocyclic benzopyran-based derivatives as new anti-ischemic activators of mitochondrial ATP-sensitive potassium channel. Journal of medicinal chemistry, 2008, Nov-13, Volume: 51, Issue:21 Topics: Animals; Benzopyrans; Blood Pressure; KATP Channels; Male; Mitochondria; Molecular Structure; Myocardial Ischemia; Rats; Rats, Wistar; Spiro Compounds; Structure-Activity Relationship	2008
Enantioselectivity in cardioprotection induced by (S)- (-)-2,2-dimethyl-N-(4'-acetamido-benzyl)-4-spiromorpholone-chromane. Journal of medicinal chemistry, 2009, Mar-12, Volume: 52, Issue:5 Topics: Animals; Benzopyrans; Cardiotonic Agents; Chromatography, High Pressure Liquid; Circular Dichroism; Crystallography, X-Ray; In Vitro Techniques; Models, Molecular; Molecular Conformation; Myocardial Ischemia; Myocardial Reperfusion; Rats; Spiro Compounds; Stereoisomerism; Structure-Activity Relationship	2009