crizotinib and Corneal-Diseases

crizotinib has been researched along with Corneal-Diseases* in 1 studies

Other Studies

1 other study(ies) available for crizotinib and Corneal-Diseases

Article	Year
Management of anaplastic lymphoma kinase positive orbito-conjunctival inflammatory myofibroblastic tumor with crizotinib. Journal of AAPOS : the official publication of the American Association for Pediatric Ophthalmology and Strabismus, 2016, Volume: 20, Issue:3 Inflammatory myofibroblastic tumor (IMT) is a distinct mesenchymal neoplasm of myofibroblastic spindle cells associated with an inflammatory infiltrate formed by lymphocytes, eosinophils, and plasma cells in a myxoid or collagenous stroma. This tumor has a predilection for children and young adults and most commonly occurs in the lungs, retroperitoneum, abdomen, and pelvis. Ocular and orbital involvement is exceedingly rare. We describe a case of IMT in a 7-year-old girl involving the cornea, conjunctiva, and the anterior orbit treated with crizotinib, resulting in complete tumor remission. Topics: Administration, Oral; Anaplastic Lymphoma Kinase; Antineoplastic Agents; Child; Conjunctival Neoplasms; Corneal Diseases; Crizotinib; Female; Humans; Magnetic Resonance Imaging; Myofibroblasts; Neoplasms, Muscle Tissue; Orbital Neoplasms; Protein Kinase Inhibitors; Pyrazoles; Pyridines; Receptor Protein-Tyrosine Kinases	2016

Article

Year

Management of anaplastic lymphoma kinase positive orbito-conjunctival inflammatory myofibroblastic tumor with crizotinib.

Journal of AAPOS : the official publication of the American Association for Pediatric Ophthalmology and Strabismus, 2016, Volume: 20, Issue:3

Inflammatory myofibroblastic tumor (IMT) is a distinct mesenchymal neoplasm of myofibroblastic spindle cells associated with an inflammatory infiltrate formed by lymphocytes, eosinophils, and plasma cells in a myxoid or collagenous stroma. This tumor has a predilection for children and young adults and most commonly occurs in the lungs, retroperitoneum, abdomen, and pelvis. Ocular and orbital involvement is exceedingly rare. We describe a case of IMT in a 7-year-old girl involving the cornea, conjunctiva, and the anterior orbit treated with crizotinib, resulting in complete tumor remission.

Topics: Administration, Oral; Anaplastic Lymphoma Kinase; Antineoplastic Agents; Child; Conjunctival Neoplasms; Corneal Diseases; Crizotinib; Female; Humans; Magnetic Resonance Imaging; Myofibroblasts; Neoplasms, Muscle Tissue; Orbital Neoplasms; Protein Kinase Inhibitors; Pyrazoles; Pyridines; Receptor Protein-Tyrosine Kinases

2016