crizotinib and Chemical-and-Drug-Induced-Liver-Injury--Chronic

Crizotinib has been approved for patients with advanced lung adenocarcinoma harboring rearrangements of the c-ROS-1 (ROS1) and anaplastic lymphoma kinase (ALK) genes. We report a patient with ROS1-rearranged lung adenocarcinoma who developed a crizotinib-induced mixed/cholestatic type of liver injury. The patient discontinued crizotinib after 34 days due to liver toxicity. Twenty-four days later, when transaminases and C reactive protein (CRP) were normalized, crizotinib was resumed using an oral desensitization method. The patient was successfully treated for manageable recurrence of liver injury and has been able to continue the treatment.

Topics: Adenocarcinoma of Lung; Antineoplastic Agents; Chemical and Drug Induced Liver Injury, Chronic; Crizotinib; Humans; Lung Neoplasms; Male; Middle Aged; Protein Kinase Inhibitors