creatine has been researched along with Stroke in 32 studies
Stroke: A group of pathological conditions characterized by sudden, non-convulsive loss of neurological function due to BRAIN ISCHEMIA or INTRACRANIAL HEMORRHAGES. Stroke is classified by the type of tissue NECROSIS, such as the anatomic location, vasculature involved, etiology, age of the affected individual, and hemorrhagic vs. non-hemorrhagic nature. (From Adams et al., Principles of Neurology, 6th ed, pp777-810)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Choline and creatine are commonly used as denominators for other metabolites in ischemic stroke spectroscopy, assuming that they do not change." | 7.74 | Choline and creatine are not reliable denominators for calculating metabolite ratios in acute ischemic stroke. ( Armitage, PA; Bastin, ME; Cvoro, V; Marshall, I; Muñoz Maniega, S; Wardlaw, JM, 2008) |
| "Stroke is a leading cause of mortality and disability, and its sequelae are associated with inadequate food intake which can lead to sarcopenia." | 7.30 | Influence of CReatine supplementation on mUScle mass and strength after stroke (ICaRUS Stroke Trial): study protocol for a randomized controlled trial. ( Atherton, PJ; Azevedo, PS; Bazan, R; Bazan, SGZ; Costa, VE; de Paiva, SAR; de Souza, JT; Fernandes, MFP; Ferreira, NC; Gordon, A; Minicucci, MF; Modolo, GP; Okoshi, MP; Phillips, BE; Polegato, BF; Smith, K; Tanni, SE; Wilkinson, D; Zornoff, LAM, 2023) |
| "We sought to measure the temporal evolution and spatial distribution of lesion macromolecules and small molecules (lactate, N-acetyl compounds, creatine, and choline) in stroke patients by using short echo time in vivo proton MR spectroscopy." | 5.09 | Spectroscopic assessment of alterations in macromolecule and small-molecule metabolites in human brain after stroke. ( Graham, GD; Hwang, JH; Prichard, JW; Rothman, DL, 2001) |
| "Lesional NAA and creatine were significantly lower in subacute than in acute stroke." | 4.31 | Predicting the Onset of Ischemic Stroke With Fast High-Resolution 3D MR Spectroscopic Imaging. ( Bo, B; Guan, Y; Guo, R; Li, Y; Liang, ZP; Lin, DJ; Lin, Z; Liu, J; Meng, Z; Nachev, P; Wang, T; Yu, X; Zhao, Y; Zhou, H, 2023) |
| "l-arginine:glycine amidinotransferase (AGAT) and its metabolites homoarginine (hArg) and creatine have been linked to stroke pathology in both human and mouse studies." | 3.96 | Homoarginine- and Creatine-Dependent Gene Regulation in Murine Brains with l-Arginine:Glycine Amidinotransferase Deficiency. ( Arunachalam, P; Choe, CU; Gelderblom, M; Gerloff, C; Jensen, M; Magnus, T; Müller, C; Schwedhelm, E; Zeller, T, 2020) |
| "The NAA/Cr (N-acetyl aspartate/creatine) of the bilateral hippocampus of the cognitive impairment group was lower than those of both control group of stroke and health (p < 0." | 3.85 | Study on the clinical application of the MRS in the cognitive assessment after stroke. ( Chen, W; Gong, ZK; Sheng, C; Wang, M; Wang, SY; Wang, XX, 2017) |
| "Prolonged oral creatine administration resulted in remarkable neuroprotection in experimental models of brain stroke." | 3.77 | Creatinyl amino acids: new hybrid compounds with neuroprotective activity. ( Burov, S; Dobrodumov, A; Dorosh, M; Leko, M; Veselkina, O, 2011) |
| "Choline and creatine are commonly used as denominators for other metabolites in ischemic stroke spectroscopy, assuming that they do not change." | 3.74 | Choline and creatine are not reliable denominators for calculating metabolite ratios in acute ischemic stroke. ( Armitage, PA; Bastin, ME; Cvoro, V; Marshall, I; Muñoz Maniega, S; Wardlaw, JM, 2008) |
| "Stroke is a leading cause of mortality and disability, and its sequelae are associated with inadequate food intake which can lead to sarcopenia." | 3.30 | Influence of CReatine supplementation on mUScle mass and strength after stroke (ICaRUS Stroke Trial): study protocol for a randomized controlled trial. ( Atherton, PJ; Azevedo, PS; Bazan, R; Bazan, SGZ; Costa, VE; de Paiva, SAR; de Souza, JT; Fernandes, MFP; Ferreira, NC; Gordon, A; Minicucci, MF; Modolo, GP; Okoshi, MP; Phillips, BE; Polegato, BF; Smith, K; Tanni, SE; Wilkinson, D; Zornoff, LAM, 2023) |
| "NAA/choline (Cho) ratios were significantly reduced in both areas of T2 hyperintensity and in surrounding tissue." | 2.70 | Spectroscopic data following stroke reveal tissue abnormality beyond the region of T2-weighted hyperintensity. ( Beley, A; Brunotte, F; Demougeot, C; Giroud, M; Marie, C; Rouaud, O; Walker, P, 2002) |
| "Phosphocreatine (PCr) has been administered after human MI, where it proved to be safe and probably helpful." | 2.49 | Therapeutic use of creatine in brain or heart ischemia: available data and future perspectives. ( Balestrino, M; Gandolfo, C; Perasso, L; Ruggeri, P; Spallarossa, P, 2013) |
| "Patients with renal insufficiency are more likely to die after coronary revascularization, but mild renal insufficiency is neglected and little is known about its clinical effects." | 1.34 | Prevalence and impact of renal insufficiency on clinical outcomes of patients undergoing coronary revascularization. ( Chen, F; Dong, JZ; Du, X; Gu, CX; Hu, R; Huang, FJ; Jia, CQ; Kang, JP; Liu, XH; Liu, XM; Lv, Q; Lv, SZ; Ma, CS; Nie, SP; Wu, XS; Zhang, Q; Zhang, Y; Zhou, YJ, 2007) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 14 (43.75) | 29.6817 |
| 2010's | 13 (40.63) | 24.3611 |
| 2020's | 5 (15.63) | 2.80 |
| Authors | Studies |
|---|---|
| Diprose, WK | 1 |
| Morgan, CA | 1 |
| Wang, MT | 1 |
| Diprose, JP | 1 |
| Lin, JC | 1 |
| Sheriff, S | 1 |
| Campbell, D | 1 |
| Barber, PA | 1 |
| Laredo, C | 1 |
| Rodríguez, A | 1 |
| Oleaga, L | 1 |
| Hernández-Pérez, M | 1 |
| Renú, A | 1 |
| Puig, J | 1 |
| Román, LS | 1 |
| Planas, AM | 1 |
| Urra, X | 1 |
| Chamorro, Á | 1 |
| Lin, Z | 1 |
| Meng, Z | 1 |
| Wang, T | 1 |
| Guo, R | 1 |
| Zhao, Y | 1 |
| Li, Y | 2 |
| Bo, B | 1 |
| Guan, Y | 1 |
| Liu, J | 1 |
| Zhou, H | 1 |
| Yu, X | 1 |
| Lin, DJ | 1 |
| Liang, ZP | 1 |
| Nachev, P | 1 |
| de Souza, JT | 1 |
| Minicucci, MF | 1 |
| Ferreira, NC | 1 |
| Polegato, BF | 1 |
| Okoshi, MP | 1 |
| Modolo, GP | 1 |
| Phillips, BE | 1 |
| Atherton, PJ | 1 |
| Smith, K | 1 |
| Wilkinson, D | 1 |
| Gordon, A | 1 |
| Tanni, SE | 1 |
| Costa, VE | 1 |
| Fernandes, MFP | 1 |
| Bazan, SGZ | 1 |
| Zornoff, LAM | 1 |
| Bazan, R | 1 |
| de Paiva, SAR | 1 |
| Azevedo, PS | 1 |
| Jensen, M | 1 |
| Müller, C | 1 |
| Schwedhelm, E | 1 |
| Arunachalam, P | 1 |
| Gelderblom, M | 1 |
| Magnus, T | 1 |
| Gerloff, C | 1 |
| Zeller, T | 1 |
| Choe, CU | 1 |
| Wang, SY | 1 |
| Wang, M | 1 |
| Wang, XX | 1 |
| Chen, W | 1 |
| Sheng, C | 1 |
| Gong, ZK | 1 |
| Medrano Navarro, AL | 1 |
| Justel Enríquez, A | 1 |
| Alameda Serrano, J | 1 |
| Blasco Lamarca, Y | 1 |
| Sáenz Abad, D | 1 |
| Gimeno Orna, JA | 1 |
| Bayer-Karpinska, A | 1 |
| Schwarz, F | 1 |
| Wollenweber, FA | 1 |
| Poppert, H | 1 |
| Boeckh-Behrens, T | 1 |
| Becker, A | 1 |
| Clevert, DA | 1 |
| Nikolaou, K | 1 |
| Opherk, C | 1 |
| Dichgans, M | 1 |
| Saam, T | 1 |
| Zaiss, M | 1 |
| Xu, J | 1 |
| Goerke, S | 1 |
| Khan, IS | 1 |
| Singer, RJ | 1 |
| Gore, JC | 1 |
| Gochberg, DF | 1 |
| Bachert, P | 1 |
| Shemesh, N | 1 |
| Rosenberg, JT | 1 |
| Dumez, JN | 1 |
| Grant, SC | 1 |
| Frydman, L | 1 |
| Bivard, A | 1 |
| Yassi, N | 1 |
| Krishnamurthy, V | 1 |
| Lin, L | 1 |
| Levi, C | 1 |
| Spratt, NJ | 1 |
| Mittef, F | 1 |
| Davis, S | 1 |
| Parsons, M | 1 |
| Meng, N | 1 |
| Shi, S | 1 |
| Su, Y | 1 |
| Auriel, E | 1 |
| Kliper, E | 1 |
| Shenhar-Tsarfaty, S | 1 |
| Molad, J | 1 |
| Berliner, S | 1 |
| Shapira, I | 1 |
| Ben-Bashat, D | 1 |
| Shopin, L | 1 |
| Tene, O | 1 |
| Rosenberg, GA | 1 |
| Bornstein, NM | 1 |
| Ben Assayag, E | 1 |
| Zhang, L | 2 |
| Sui, R | 1 |
| Zhang, Z | 1 |
| Jiménez-Xarrié, E | 1 |
| Davila, M | 1 |
| Candiota, AP | 1 |
| Delgado-Mederos, R | 1 |
| Ortega-Martorell, S | 1 |
| Julià-Sapé, M | 1 |
| Arús, C | 1 |
| Martí-Fàbregas, J | 1 |
| Muñoz Maniega, S | 1 |
| Cvoro, V | 1 |
| Armitage, PA | 1 |
| Marshall, I | 1 |
| Bastin, ME | 1 |
| Wardlaw, JM | 1 |
| Mikkelsen, MM | 1 |
| Andersen, NH | 1 |
| Christensen, TD | 1 |
| Hansen, TK | 1 |
| Eiskjaer, H | 1 |
| Mogensen, CE | 1 |
| Hjortdal, VE | 1 |
| Johnsen, SP | 1 |
| An, L | 1 |
| Zhang, Y | 2 |
| Thomasson, DM | 1 |
| Latour, LL | 1 |
| Baker, EH | 1 |
| Shen, J | 1 |
| Warach, S | 1 |
| Wang, X | 1 |
| Li, YH | 1 |
| Li, MH | 1 |
| Lu, J | 1 |
| Zhao, JG | 1 |
| Sun, XJ | 1 |
| Zhang, B | 1 |
| Ye, JL | 1 |
| Burov, S | 1 |
| Leko, M | 1 |
| Dorosh, M | 1 |
| Dobrodumov, A | 1 |
| Veselkina, O | 1 |
| Perasso, L | 1 |
| Spallarossa, P | 1 |
| Gandolfo, C | 1 |
| Ruggeri, P | 1 |
| Balestrino, M | 1 |
| Rumpel, H | 1 |
| Lim, WE | 1 |
| Chang, HM | 1 |
| Chan, LL | 1 |
| Ho, GL | 1 |
| Wong, MC | 1 |
| Tan, KP | 1 |
| Sutherland, S | 1 |
| Ross, AJ | 1 |
| Sachdev, PS | 1 |
| Wen, W | 1 |
| Brodaty, H | 1 |
| Joscelyne, A | 1 |
| Lorentz, LM | 1 |
| Glodzik-Sobanska, L | 1 |
| Li, J | 1 |
| Mosconi, L | 1 |
| Slowik, A | 1 |
| Walecki, J | 1 |
| Szczudlik, A | 1 |
| Sobiecka, B | 1 |
| de Leon, MJ | 1 |
| Zhang, Q | 1 |
| Ma, CS | 1 |
| Nie, SP | 1 |
| Du, X | 1 |
| Lv, Q | 1 |
| Kang, JP | 1 |
| Hu, R | 1 |
| Jia, CQ | 1 |
| Liu, XM | 1 |
| Liu, XH | 1 |
| Dong, JZ | 1 |
| Chen, F | 1 |
| Zhou, YJ | 1 |
| Lv, SZ | 1 |
| Huang, FJ | 1 |
| Gu, CX | 1 |
| Wu, XS | 1 |
| Andres, RH | 1 |
| Ducray, AD | 1 |
| Schlattner, U | 1 |
| Wallimann, T | 1 |
| Widmer, HR | 1 |
| Vahedi, K | 1 |
| Domigo, V | 1 |
| Amarenco, P | 1 |
| Bousser, MG | 1 |
| Kobayashi, M | 1 |
| Takayama, H | 1 |
| Suga, S | 1 |
| Mihara, B | 1 |
| Graham, GD | 1 |
| Hwang, JH | 1 |
| Rothman, DL | 1 |
| Prichard, JW | 1 |
| Chu, WJ | 1 |
| Mason, GF | 1 |
| Pan, JW | 1 |
| Hetherington, HP | 1 |
| Liu, HG | 1 |
| San Pedro, EC | 1 |
| Mountz, JM | 1 |
| Demougeot, C | 1 |
| Walker, P | 1 |
| Beley, A | 1 |
| Marie, C | 1 |
| Rouaud, O | 1 |
| Giroud, M | 1 |
| Brunotte, F | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| CHemical OptImization of Cerebral Embolectomy in Patients With Acute Stroke Treated With Mechanical Thrombectomy 2 (CHOICE 2 TRIAL)[NCT05797792] | Phase 3 | 440 participants (Anticipated) | Interventional | 2023-06-01 | Not yet recruiting | ||
| Carotid Plaque Imaging in Acute Stroke[NCT01284933] | 234 participants (Actual) | Observational | 2011-02-28 | Completed | |||
| Remote Effects of Stroke on Cerebral Metabolism. Evaluation With Positron Emission Tomography and Proton Magnetic Resonance Spectroscopy[NCT00063180] | 70 participants | Observational | 2003-06-19 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
2 reviews available for creatine and Stroke
| Article | Year |
|---|---|
Therapeutic use of creatine in brain or heart ischemia: available data and future perspectives.
Topics: Blood-Brain Barrier; Brain Ischemia; Cardiotonic Agents; Creatine; Female; Forecasting; Humans; In V | 2013 |
Functions and effects of creatine in the central nervous system.
Topics: Animals; Brain Diseases, Metabolic; Brain Injuries; Central Nervous System; Creatine; Creatine Kinas | 2008 |
6 trials available for creatine and Stroke
| Article | Year |
|---|---|
Adjunct Thrombolysis Enhances Brain Reperfusion following Successful Thrombectomy.
Topics: Aged; Aged, 80 and over; Brain; Brain Ischemia; Cerebral Infarction; Creatine; Endovascular Procedur | 2022 |
Influence of CReatine supplementation on mUScle mass and strength after stroke (ICaRUS Stroke Trial): study protocol for a randomized controlled trial.
Topics: Creatine; Dietary Supplements; Double-Blind Method; Hand Strength; Humans; Muscle Strength; Muscles; | 2023 |
Longitudinal changes of metabolites in frontal lobes after hemorrhagic stroke of basal ganglia: a proton magnetic resonance spectroscopy study.
Topics: Aged; Aged, 80 and over; Aspartic Acid; Basal Ganglia Hemorrhage; Creatine; Disease Progression; Fem | 2001 |
Spectroscopic assessment of alterations in macromolecule and small-molecule metabolites in human brain after stroke.
Topics: Adult; Age Factors; Aged; Aged, 80 and over; Brain; Choline; Creatine; Disease Progression; Female; | 2001 |
Regional cerebral blood flow and magnetic resonance spectroscopic imaging findings in diaschisis from stroke.
Topics: Adult; Aged; Aspartic Acid; Blood Flow Velocity; Brain; Cerebral Infarction; Cerebrovascular Circula | 2002 |
Spectroscopic data following stroke reveal tissue abnormality beyond the region of T2-weighted hyperintensity.
Topics: Aspartic Acid; Choline; Creatine; Female; Humans; Infarction, Middle Cerebral Artery; Lactic Acid; M | 2002 |
24 other studies available for creatine and Stroke
| Article | Year |
|---|---|
Active conductive head cooling of normal and infarcted brain: A magnetic resonance spectroscopy imaging study.
Topics: Body Temperature; Brain; Brain Infarction; Choline; Creatine; Humans; Hypothermia, Induced; Magnetic | 2022 |
Predicting the Onset of Ischemic Stroke With Fast High-Resolution 3D MR Spectroscopic Imaging.
Topics: Aspartic Acid; Bayes Theorem; Choline; Creatine; Cross-Sectional Studies; Humans; Ischemic Stroke; L | 2023 |
Homoarginine- and Creatine-Dependent Gene Regulation in Murine Brains with l-Arginine:Glycine Amidinotransferase Deficiency.
Topics: Amidinotransferases; Amino Acid Metabolism, Inborn Errors; Animals; Arginine; Brain; Creatine; Devel | 2020 |
Study on the clinical application of the MRS in the cognitive assessment after stroke.
Topics: Aspartic Acid; Cognition; Cognition Disorders; Cognitive Dysfunction; Creatine; Hippocampus; Humans; | 2017 |
Total and cardiovascular mortality risk according to KDIGO guidelines classification in type 2 diabetic patients.
Topics: Adult; Albuminuria; Analysis of Variance; Cardiovascular Diseases; Cause of Death; Chi-Square Distri | 2019 |
The carotid plaque imaging in acute stroke (CAPIAS) study: protocol and initial baseline data.
Topics: Aged; Carotid Stenosis; Cerebral Cortex; Cognition Disorders; Cohort Studies; Creatine; Disease Prog | 2013 |
Inverse Z-spectrum analysis for spillover-, MT-, and T1 -corrected steady-state pulsed CEST-MRI--application to pH-weighted MRI of acute stroke.
Topics: Amides; Animals; Creatine; Hydrogen-Ion Concentration; Magnetic Resonance Imaging; Male; Phantoms, I | 2014 |
Metabolic T1 dynamics and longitudinal relaxation enhancement in vivo at ultrahigh magnetic fields on ischemia.
Topics: Animals; Aspartic Acid; Brain Ischemia; Cerebral Angiography; Cerebrovascular Circulation; Choline; | 2014 |
A comprehensive analysis of metabolic changes in the salvaged penumbra.
Topics: Adult; Aged; Aged, 80 and over; Brain Ischemia; Case-Control Studies; Creatine; Female; Glutamic Aci | 2016 |
Proton magnetic resonance spectroscopy as a diagnostic biomarker in mild cognitive impairment following stroke in acute phase.
Topics: Aged; Aspartic Acid; Biomarkers; Cognitive Dysfunction; Creatine; Female; Hippocampus; Humans; Male; | 2016 |
Impaired renal function is associated with brain atrophy and poststroke cognitive decline.
Topics: Aged; Atrophy; Brain; Brain Ischemia; Cognitive Dysfunction; Creatine; Diffusion Tensor Imaging; Fem | 2016 |
Morphological and Metabolic Alteration of Cerebellum in Patients with Post-Stroke Depression.
Topics: Anisotropy; Case-Control Studies; Cerebellum; Choline; Creatine; Depression; Female; Humans; Magneti | 2016 |
Brain metabolic pattern analysis using a magnetic resonance spectra classification software in experimental stroke.
Topics: Animals; Brain; Brain Ischemia; Creatine; Image Processing, Computer-Assisted; Inositol; Lactic Acid | 2017 |
Choline and creatine are not reliable denominators for calculating metabolite ratios in acute ischemic stroke.
Topics: Acute Disease; Aged; Aged, 80 and over; Biomarkers; Brain; Brain Ischemia; Choline; Creatine; Down-R | 2008 |
Microalbuminuria and short-term prognosis in patients undergoing cardiac surgery.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Albumins; Albuminuria; Atrial Fibrillation; Biomarkers; | 2009 |
Measurement of glutathione in normal volunteers and stroke patients at 3T using J-difference spectroscopy with minimized subtraction errors.
Topics: Adult; Aspartic Acid; Biomarkers; Case-Control Studies; Choline; Creatine; Female; Glutathione; Huma | 2009 |
Glutamate level detection by magnetic resonance spectroscopy in patients with post-stroke depression.
Topics: Aged; Aspartic Acid; Brain; Brain Mapping; Creatine; Depression; Female; Glutamic Acid; Humans; Inos | 2012 |
Creatinyl amino acids: new hybrid compounds with neuroprotective activity.
Topics: Amino Acids; Animals; Blood-Brain Barrier; Creatine; Male; Molecular Structure; Neuroprotective Agen | 2011 |
Is myo-inositol a measure of glial swelling after stroke? A magnetic resonance study.
Topics: Aged; Aged, 80 and over; Brain Edema; Creatine; Female; Humans; Inositol; Magnetic Resonance Imaging | 2003 |
Creatine as a neuroprotector.
Topics: Animals; Creatine; Mice; Mitochondria; Neuroprotective Agents; Stroke | 2004 |
Prediction of cognitive decline after stroke using proton magnetic resonance spectroscopy.
Topics: Aged; Aged, 80 and over; Analysis of Variance; Aspartic Acid; Brain Chemistry; Cognition Disorders; | 2006 |
Prefrontal N-acetylaspartate and poststroke recovery: a longitudinal proton spectroscopy study.
Topics: Aged; Aged, 80 and over; Aspartic Acid; Brain Ischemia; Creatine; Female; Follow-Up Studies; Functio | 2007 |
Prevalence and impact of renal insufficiency on clinical outcomes of patients undergoing coronary revascularization.
Topics: Adult; Aged; Creatine; Female; Hospital Mortality; Humans; Male; Middle Aged; Myocardial Infarction; | 2007 |
Ischaemic stroke in a sportsman who consumed MaHuang extract and creatine monohydrate for body building.
Topics: Adult; Brain Ischemia; Creatine; Ephedra sinica; Ephedrine; Humans; Male; Plant Preparations; Stroke | 2000 |