creatine and Patency of the Ductus Arteriosus studies

Research Excerpts

Excerpt	Relevance	Reference
"To document trends and covariates of creatinemia (Scr) in extremely low birth weight (ELBW, < 1,000 g) neonates, maternal characteristics [betamethasone, premature preterm rupture of membranes (PPROM), pre-eclampsia, maternal Scr], characteristics at delivery [gestational age (GA), birth weight (BW), small for GA (SGA), Apgar, intubation] and during neonatal stay [ventilation, oxygen, parenteral nutrition, ibuprofen, steroids, intraventricular hemorrhage, retinopathy of prematurity (ROP), phototherapy] were linked with Scr observations."	7.77	Postnatal trends in creatinemia and its covariates in extremely low birth weight (ELBW) neonates. ( Allegaert, K; George, I; Levtchenko, E; Mekahli, D; Rayyan, M, 2011)
"To document trends and covariates of creatinemia (Scr) in extremely low birth weight (ELBW, < 1,000 g) neonates, maternal characteristics [betamethasone, premature preterm rupture of membranes (PPROM), pre-eclampsia, maternal Scr], characteristics at delivery [gestational age (GA), birth weight (BW), small for GA (SGA), Apgar, intubation] and during neonatal stay [ventilation, oxygen, parenteral nutrition, ibuprofen, steroids, intraventricular hemorrhage, retinopathy of prematurity (ROP), phototherapy] were linked with Scr observations."	3.77	Postnatal trends in creatinemia and its covariates in extremely low birth weight (ELBW) neonates. ( Allegaert, K; George, I; Levtchenko, E; Mekahli, D; Rayyan, M, 2011)
"Hemodynamically significant patent ductus arteriosus (hsPDA) complicates the clinical course of preterm infants and contributes to increased morbidity and mortality."	1.39	Elevated urinary NT-proBNP after pharmacological closure of patent ductus arteriosus in very low birth weight infants. ( Canpolat, FE; Celik, IH; Demırel, G; Dilmen, U; Erdeve, O, 2013)

Research

Studies (5)

Authors

Clinical Trials (2)

Trial Overview

Trial Outcomes

% Weight Change

Timeframe	Studies, this research(%)	All Research%
pre-1990	1 (20.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	1 (20.00)	29.6817
2010's	3 (60.00)	24.3611
2020's	0 (0.00)	2.80

Authors	Studies
George, I	1
Mekahli, D	1
Rayyan, M	1
Levtchenko, E	1
Allegaert, K	1
Czernik, C	1
Metze, B	1
Müller, C	1
Bührer, C	1
Celik, IH	1
Erdeve, O	1
Demırel, G	1
Canpolat, FE	1
Dilmen, U	1
Gawlowski, Z	1
Aladangady, N	1
Coen, PG	1
Hartwig, A	1
Syllm-Rapoport, I	1
Daniel, A	1
Bartel, J	1

Trial	Phase	Enrollment	Study Type	Start Date	Status
Prematurity as Predictor of Children's Cardiovascular-renal Health (PREMATCH)[NCT02147457]		180 participants (Actual)	Observational	2014-10-31	Completed
Early Sodium Intake in Preterm Newborns; Randomized Clinical Trial[NCT04035564]	Phase 4	52 participants (Actual)	Interventional	2018-03-30	Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

The difference between initial weight and 72hrs weight, expressed in percentage of birth weight. (NCT04035564)
Timeframe: Initial weight (baseline) vs 72 hours

Change in Serum Sodium

Intervention	% of birth weight (Mean)
Sodium < 1mEq/kg/Day	-9.206
Sodium 5mEq/kg/Day	-6.345

The difference between current serum sodium and initial serum sodium (NCT04035564)
Timeframe: Initial serum sodium (baseline) vs 72 hours

Hypernatremia

Hyponatremia

Mortality

Intervention	mEq/L (Mean)
Sodium < 1mEq/kg/Day	1.921
Sodium 5mEq/kg/Day	5.71

Intervention	Participants (Count of Participants)
Sodium < 1mEq/kg/Day	1
Sodium 5mEq/kg/Day	1

Intervention	Participants (Count of Participants)
Sodium < 1mEq/kg/Day	6
Sodium 5mEq/kg/Day	1

Death during hospitalization. (NCT04035564)
Timeframe: Patients will be followed during hospitalization, an expected average of 3 months of age

Number of Participants With Intraventricular Hemorrhage

Intervention	Participants (Count of Participants)
Sodium < 1mEq/kg/Day	5
Sodium 5mEq/kg/Day	2

Bleeding into the brain´s ventricular system (intracranial ultrasound). (NCT04035564)
Timeframe: Patients will be followed during hospitalization, an expected average of 3 months of age

Number of Participants With Late-onset Sepsis

Intervention	Participants (Count of Participants)
Sodium < 1mEq/kg/Day	6
Sodium 5mEq/kg/Day	4

Positive blood culture and/or 5 days of continuous antimicrobial therapy (NCT04035564)
Timeframe: Patients will be followed during hospitalization, an expected average of 3 months of age

Number of Participants With Necrotizing Enterocolitis

Intervention	Participants (Count of Participants)
Sodium < 1mEq/kg/Day	8
Sodium 5mEq/kg/Day	5

"Number of patients with Bell stage II or greater necrotizing enterocolitis~Bell's Staging:~Stage II A:~Gastrointestinal signs: Increasing gastric aspirates, mild abdominal distention, fecal occult blood, absent bowel sounds.~Systemic signs: Temperature instability, apnea, bradycardia, lethargy. Radiological findings: Intestinal dilatation, ileus, pneumatosis intestinalis.~Stage II B:~Gastrointestinal signs: As stage IIA plus abdominal tenderness. Systemic signs: As stage IIA plus metabolic acidosis and thrombocytopenia. Radiological findings: As stage IIA plus portal vein gas and ascites.~Stage III A:~Gastrointestinal signs: As stage IIB plus marked abdominal tenderness and generalised peritonitis.~Systemic signs: As stage IIB plus hypotension and severe apnea. Radiological findings: As stage IIB~Stage III B:~Gastrointestinal signs: As stage IIIA As stage IIIA As stage IIIA plus pneumoperitoneum" (NCT04035564)
Timeframe: Patients will be followed during hospitalization, an expected average of 3 months of age

Weight Change

Intervention	Participants (Count of Participants)
Sodium < 1mEq/kg/Day	2
Sodium 5mEq/kg/Day	2

The difference between current weight and initial weight (NCT04035564)
Timeframe: Initial weight (baseline) vs 72 hours

Article	Year
Postnatal trends in creatinemia and its covariates in extremely low birth weight (ELBW) neonates. Pediatric nephrology (Berlin, Germany), 2011, Volume: 26, Issue:10 Topics: Adult; Aging; Anti-Inflammatory Agents, Non-Steroidal; Apgar Score; Birth Weight; Cohort Studies; Cr	2011
Urinary NT-proBNP and ductal closure in preterm infants. Journal of perinatology : official journal of the California Perinatal Association, 2013, Volume: 33, Issue:3 Topics: Anti-Inflammatory Agents, Non-Steroidal; Biomarkers; Creatine; Ductus Arteriosus, Patent; Echocardio	2013
Elevated urinary NT-proBNP after pharmacological closure of patent ductus arteriosus in very low birth weight infants. Early human development, 2013, Volume: 89, Issue:3 Topics: Biomarkers; Creatine; Ductus Arteriosus, Patent; Echocardiography, Doppler; Enzyme-Linked Immunosorb	2013
Hypernatraemia in preterm infants born at less than 27 weeks gestation. Journal of paediatrics and child health, 2006, Volume: 42, Issue:12 Topics: Birth Weight; Creatine; Ductus Arteriosus, Patent; Enterocolitis, Necrotizing; Female; Fluid Therapy	2006
[Erythrocyte creatine concentration in infants and children with congenital heart disease and left-to-right shunts (author's transl)]. Herz, 1982, Volume: 7, Issue:1 Topics: Blood Cell Count; Blood Pressure; Child, Preschool; Creatine; Ductus Arteriosus, Patent; Erythrocyte	1982

creatine and Patency of the Ductus Arteriosus