creatine has been researched along with Osteoporosis, Postmenopausal in 8 studies
Osteoporosis, Postmenopausal: Metabolic disorder associated with fractures of the femoral neck, vertebrae, and distal forearm. It occurs commonly in women within 15-20 years after menopause, and is caused by factors associated with menopause including estrogen deficiency.
| Excerpt | Relevance | Reference |
|---|---|---|
| " We conclude that, given rectally, sCT is well absorbed and well tolerated and that it has a beneficial effect on calcium metabolism in moderately osteoporotic women." | 2.67 | Rectal salmon calcitonin for the treatment of postmenopausal osteoporosis. ( Christiansen, C; Dirksen, KL; Hansen, MA; Overgaard, K, 1992) |
| " Risedronate was safe and effective in osteoporotic women with mild, moderate, or severe age-related renal impairment." | 2.43 | Safety and efficacy of risedronate in patients with age-related reduced renal function as estimated by the Cockcroft and Gault method: a pooled analysis of nine clinical trials. ( Barton, IP; Boonen, S; Burgio, DE; Dunlap, LE; Miller, PD; Roux, C, 2005) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 4 (50.00) | 18.2507 |
| 2000's | 3 (37.50) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 1 (12.50) | 2.80 |
| Authors | Studies |
|---|---|
| Chilibeck, PD | 1 |
| Candow, DG | 1 |
| Gordon, JJ | 1 |
| Duff, WRD | 1 |
| Mason, R | 1 |
| Shaw, K | 1 |
| Taylor-Gjevre, R | 1 |
| Nair, B | 1 |
| Zello, GA | 1 |
| Deal, C | 1 |
| Omizo, M | 1 |
| Schwartz, EN | 1 |
| Eriksen, EF | 1 |
| Cantor, P | 1 |
| Wang, J | 1 |
| Glass, EV | 1 |
| Myers, SL | 1 |
| Krege, JH | 1 |
| Miller, PD | 1 |
| Roux, C | 2 |
| Boonen, S | 1 |
| Barton, IP | 1 |
| Dunlap, LE | 1 |
| Burgio, DE | 1 |
| Rozenberg, S | 1 |
| Gevers, R | 1 |
| Peretz, A | 1 |
| Vandromme, J | 1 |
| Robyn, C | 1 |
| Ham, H | 1 |
| Reginster, JY | 1 |
| Christiansen, C | 2 |
| Fechtenbaum, J | 1 |
| Rouillon, A | 1 |
| Tou, KP | 1 |
| Overgaard, K | 1 |
| Hansen, MA | 1 |
| Dirksen, KL | 1 |
| Elders, PJ | 1 |
| Netelenbos, JC | 1 |
| Lips, P | 1 |
| van Ginkel, FC | 1 |
| Khoe, E | 1 |
| Leeuwenkamp, OR | 1 |
| Hackeng, WH | 1 |
| van der Stelt, PF | 1 |
| Morris, HA | 1 |
| Wishart, JM | 1 |
| Horowitz, M | 1 |
| Need, AG | 1 |
| Nordin, BE | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Randomized Control Trial of Bone Loading Exercises Versus Risedronate on Bone Health in Post-Menopausal Women[NCT02186600] | Phase 3 | 276 participants (Actual) | Interventional | 2015-02-01 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Bone mineral density is the gold standard for diagnosis of low bone mass and osteoporosis and will be measured at the spine using Dual Energy X-ray Absorptiometry (DXA). (NCT02186600)
Timeframe: Baseline,6, and 12 months
| Intervention | g/cm^2 (Mean) | ||
|---|---|---|---|
| Baseline | 6 Months | 12 Months | |
| Control | 0.889 | .887 | 0.885 |
| Exercise | 0.886 | .878 | 0.885 |
| Risedronate | 0.892 | .907 | 0.911 |
"Change in Bone Strength Index (BSI) of the distal tibia based on randomization to Control, Risedronate, or Exercise group.~BSI (mg2/mm4) at the 4% tibial site will be measured using peripheral quantitative computed tomography (pQCT)." (NCT02186600)
Timeframe: Baseline, 6, and 12 months
| Intervention | mg^2/mm^4 (Mean) | ||
|---|---|---|---|
| Baseline | 6 Months | 12 Months | |
| Control | 2098.7 | 2105.89 | 2107.2 |
| Exercise | 2001 | 1987.42 | 2009.2 |
| Risedronate | 1993.3 | 1997.32 | 2014.2 |
Bone turnover is the process of removing old bone (resorption by osteoclasts) and replacing it with new bone (formation by osteoblasts). Menopause results in a brief period (~5 years) of accelerated turnover with resorption far exceeding formation. In this study, resorption will be measured by Serum NTx. (NCT02186600)
Timeframe: Baseline, 6, 12 months
| Intervention | nanoMolar Bone Collagen Equivalents/L (Mean) | ||
|---|---|---|---|
| Baseline | 6 Months | 12 Months | |
| Control | 13.99 | 12.16 | 12.36 |
| Exercise | 15.03 | 13.36 | 13.92 |
| Risedronate | 14.31 | 10.30 | 11.42 |
1 review available for creatine and Osteoporosis, Postmenopausal
| Article | Year |
|---|---|
Safety and efficacy of risedronate in patients with age-related reduced renal function as estimated by the Cockcroft and Gault method: a pooled analysis of nine clinical trials.
Topics: Age Factors; Aged; Aged, 80 and over; Algorithms; Bone Density; Bone Density Conservation Agents; Bo | 2005 |
5 trials available for creatine and Osteoporosis, Postmenopausal
| Article | Year |
|---|---|
A 2-yr Randomized Controlled Trial on Creatine Supplementation during Exercise for Postmenopausal Bone Health.
Topics: Bone Density; Creatine; Dietary Supplements; Double-Blind Method; Female; Femur Neck; Humans; Middle | 2023 |
Combination teriparatide and raloxifene therapy for postmenopausal osteoporosis: results from a 6-month double-blind placebo-controlled trial.
Topics: Aged; Aged, 80 and over; Bone Density; Calcium; Collagen; Collagen Type I; Creatine; Double-Blind Me | 2005 |
Intermittent cyclic tiludronate in the treatment of osteoporosis.
Topics: Aged; Aged, 80 and over; Alkaline Phosphatase; Bone Density; Collagen; Creatine; Diphosphonates; Dou | 2001 |
Rectal salmon calcitonin for the treatment of postmenopausal osteoporosis.
Topics: Administration, Rectal; Aged; Alkaline Phosphatase; Bone and Bones; Bone Density; Calcitonin; Calciu | 1992 |
Calcium supplementation reduces vertebral bone loss in perimenopausal women: a controlled trial in 248 women between 46 and 55 years of age.
Topics: Alkaline Phosphatase; Bone and Bones; Calcium; Creatine; Dose-Response Relationship, Drug; Female; F | 1991 |
2 other studies available for creatine and Osteoporosis, Postmenopausal
| Article | Year |
|---|---|
Decrease of bone mineral density during estrogen substitution therapy.
Topics: Alkaline Phosphatase; Bone Density; Creatine; Dehydroepiandrosterone; Dehydroepiandrosterone Sulfate | 1993 |
The reproducibility of bone-related biochemical variables in post-menopausal women.
Topics: Aged; Biomarkers; Calcium; Creatine; Female; Humans; Hydroxyproline; Middle Aged; Osteoporosis, Post | 1990 |