Page last updated: 2024-10-17

creatine and Obsessive-Compulsive Disorder

creatine has been researched along with Obsessive-Compulsive Disorder in 27 studies

Obsessive-Compulsive Disorder: An anxiety disorder characterized by recurrent, persistent obsessions or compulsions. Obsessions are the intrusive ideas, thoughts, or images that are experienced as senseless or repugnant. Compulsions are repetitive and seemingly purposeful behavior which the individual generally recognizes as senseless and from which the individual does not derive pleasure although it may provide a release from tension.

Research Excerpts

ExcerptRelevanceReference
"Altered brain creatine-phosphocreatine levels might reflect changes in brain energy use and have been implicated in the pathogenesis of obsessive-compulsive disorder and major depressive disorder."7.73Increased medial thalamic creatine-phosphocreatine found by proton magnetic resonance spectroscopy in children with obsessive-compulsive disorder versus major depression and healthy controls. ( Banerjee, SP; Bhandari, R; Boyd, C; Ivey, J; Mirza, Y; O'Neill, J; Renshaw, PF; Rose, M; Rosenberg, DR; Russell, A; Smith, EA; Smith, JM, 2006)
"Altered brain creatine-phosphocreatine levels might reflect changes in brain energy use and have been implicated in the pathogenesis of obsessive-compulsive disorder and major depressive disorder."3.73Increased medial thalamic creatine-phosphocreatine found by proton magnetic resonance spectroscopy in children with obsessive-compulsive disorder versus major depression and healthy controls. ( Banerjee, SP; Bhandari, R; Boyd, C; Ivey, J; Mirza, Y; O'Neill, J; Renshaw, PF; Rose, M; Rosenberg, DR; Russell, A; Smith, EA; Smith, JM, 2006)
"In this study, N-acetyl-aspartate, a putative marker of neuronal viability, creatine/phosphocreatine, and choline levels were measured in the lateral and medical subregions of the left and right thalami using a multislice proton magnetic resonance spectroscopic imaging sequence in 11 treatment-naive, nondepressed obsessive-compulsive disorder outpatients, 8-15 years old, and 11 case-matched control subjects."3.70Proton spectroscopic imaging of the thalamus in treatment-naive pediatric obsessive-compulsive disorder. ( Fitzgerald, KD; Moore, GJ; Paulson, LA; Rosenberg, DR; Stewart, CM, 2000)
"Obsessive-compulsive disorder (OCD) and major depressive disorder (MDD) both showed cognitive impairment, and the altered neurometabolic may associate with cognitive impairment."1.72Similarities and differences in working memory and neurometabolism of obsessive-compulsive disorder and major depressive disorder. ( Chen, G; Chen, P; He, J; Jia, Y; Lai, S; Lu, Q; Song, Z; Wang, Y; Yan, S; Zhang, Y; Zhao, H; Zhong, S, 2022)

Research

Studies (27)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's1 (3.70)18.2507
2000's13 (48.15)29.6817
2010's10 (37.04)24.3611
2020's3 (11.11)2.80

Authors

AuthorsStudies
He, J1
Yan, S1
Song, Z1
Lu, Q1
Zhong, S1
Lai, S1
Wang, Y1
Chen, G1
Zhao, H1
Chen, P1
Zhang, Y1
Jia, Y1
Kosová, E1
Pajuelo, D1
Fajnerová, I1
Greguš, D1
Brunovský, M1
Stopková, P1
Škoch, A1
Fürstová, P1
Španiel, F1
Horáček, J1
Biria, M1
Cantonas, LM1
Banca, P1
Moon, CM1
Jeong, GW1
Weber, AM1
Soreni, N1
Stanley, JA1
Greco, A1
Mendlowitz, S1
Szatmari, P1
Schachar, R1
Mannasis, K1
Pires, P1
Swinson, R1
Noseworthy, MD1
Tükel, R2
Aydın, K2
Ertekin, E2
Özyıldırım, SŞ2
Taravari, V1
Barburoğlu, M1
Zhu, Y1
Fan, Q2
Han, X1
Zhang, H1
Chen, J1
Wang, Z1
Zhang, Z1
Tan, L2
Xiao, Z2
Tong, S1
Maletic-Savatic, M1
Li, Y1
Starck, G1
Ljungberg, M1
Nilsson, M1
Jönsson, L1
Lundberg, S1
Ivarsson, T1
Ribbelin, S1
Ekholm, S1
Carlsson, A1
Forssell-Aronsson, E1
Carlsson, ML1
Atmaca, M1
Yildirim, H1
Ozdemir, H1
Koc, M1
Ozler, S1
Tezcan, E1
You, C1
Wang, J1
Ross, CA1
Wang, X1
Zhang, T1
Li, J1
Chen, K1
Bédard, MJ1
Chantal, S1
Besiroglu, L1
Sozen, M1
Ozbebit, O1
Avcu, S1
Selvi, Y1
Bora, A1
Atli, A1
Unal, O1
Bulut, MD1
Lázaro, L1
Bargalló, N1
Andrés, S1
Falcón, C1
Morer, A1
Junqué, C1
Castro-Fornieles, J1
Zurowski, B1
Kordon, A1
Weber-Fahr, W1
Voderholzer, U1
Kuelz, AK1
Freyer, T1
Wahl, K1
Büchel, C1
Hohagen, F1
Russell, A3
Cortese, B1
Lorch, E1
Ivey, J3
Banerjee, SP3
Moore, GJ4
Rosenberg, DR5
Alkan, A1
Kutlu, R1
Kocak, G1
Sigirci, A1
Emul, M1
Dogan, S1
Aslan, M1
Sarac, K1
Yakinci, C1
Mirza, Y2
Tang, J1
Smith, JM2
Bhandari, R2
Rose, M2
Boyd, C2
O'Neill, J1
Smith, EA1
Renshaw, PF1
Jang, JH1
Kwon, JS1
Jang, DP1
Moon, WJ1
Lee, JM1
Ha, TH1
Chung, EC1
Kim, IY1
Kim, SI1
Kitamura, H1
Shioiri, T1
Kimura, T1
Ohkubo, M1
Nakada, T1
Someya, T1
Mohamed, MA1
Smith, MA1
Schlund, MW1
Nestadt, G1
Barker, PB1
Hoehn-Saric, R1
Scherk, H1
Backens, M1
Schneider-Axmann, T1
Kraft, S1
Kemmer, C1
Usher, J1
Reith, W1
Falkai, P1
Meyer, J1
Gruber, O1
Yücel, M1
Wood, SJ1
Wellard, RM1
Harrison, BJ1
Fornito, A1
Pujol, J1
Velakoulis, D1
Pantelis, C1
Ohara, K2
Isoda, H1
Suzuki, Y1
Takehara, Y1
Ochiai, M1
Takeda, H1
Igarashi, Y1
Fitzgerald, KD1
Paulson, LA1
Stewart, CM1
Amponsah, A1
Sullivan, A1
MacMillan, S1

Trials

2 trials available for creatine and Obsessive-Compulsive Disorder

ArticleYear
Localized functional neurochemical marker abnormalities in dorsolateral prefrontal cortex in pediatric obsessive-compulsive disorder.
    Journal of child and adolescent psychopharmacology, 2003, Volume: 13 Suppl 1

    Topics: Adolescent; Aspartic Acid; Biomarkers; Child; Choline; Creatine; Female; Humans; Image Interpretatio

2003
Brain MR spectroscopy in children with a history of rheumatic fever with a special emphasis on neuropsychiatric complications.
    European journal of radiology, 2004, Volume: 49, Issue:3

    Topics: Adolescent; Analysis of Variance; Aspartic Acid; Basal Ganglia; Child; Child, Preschool; Choline; Ch

2004

Other Studies

25 other studies available for creatine and Obsessive-Compulsive Disorder

ArticleYear
Similarities and differences in working memory and neurometabolism of obsessive-compulsive disorder and major depressive disorder.
    Journal of affective disorders, 2022, 08-15, Volume: 311

    Topics: Creatine; Depressive Disorder, Major; Humans; Magnetic Resonance Imaging; Memory Disorders; Memory,

2022
Spectroscopic abnormalities in the pregenual anterior cingulate cortex in obsessive-compulsive disorder using proton magnetic resonance spectroscopy: a controlled study.
    BMC psychiatry, 2023, 10-10, Volume: 23, Issue:1

    Topics: Aspartic Acid; Creatine; Glutamine; Gyrus Cinguli; Humans; Inositol; Magnetic Resonance Imaging; Obs

2023
Magnetic Resonance Spectroscopy (MRS) and Positron Emission Tomography (PET) Imaging in Obsessive-Compulsive Disorder.
    Current topics in behavioral neurosciences, 2021, Volume: 49

    Topics: Aspartic Acid; Creatine; Glutamic Acid; Humans; Magnetic Resonance Imaging; Magnetic Resonance Spect

2021
Associations of neurofunctional, morphometric and metabolic abnormalities with clinical symptom severity and recognition deficit in obsessive-compulsive disorder.
    Journal of affective disorders, 2018, Volume: 227

    Topics: Adult; Aspartic Acid; Brain; Brain Mapping; Case-Control Studies; Choline; Creatine; Female; Glutami

2018
Proton magnetic resonance spectroscopy of prefrontal white matter in psychotropic naïve children and adolescents with obsessive-compulsive disorder.
    Psychiatry research, 2014, Apr-30, Volume: 222, Issue:1-2

    Topics: Adolescent; Child; Choline; Creatine; Female; Humans; Inositol; Magnetic Resonance Spectroscopy; Mal

2014
Proton magnetic resonance spectroscopy in obsessive-compulsive disorder: evidence for reduced neuronal integrity in the anterior cingulate.
    Psychiatry research, 2014, Dec-30, Volume: 224, Issue:3

    Topics: Adult; Aspartic Acid; Caudate Nucleus; Choline; Creatine; Female; Gyrus Cinguli; Humans; Inositol; M

2014
1H-magnetic resonance spectroscopy in obsessive-compulsive disorder: effects of 12 weeks of sertraline treatment on brain metabolites.
    European archives of psychiatry and clinical neuroscience, 2015, Volume: 265, Issue:3

    Topics: Adult; Analysis of Variance; Aspartic Acid; Brain; Choline; Creatine; Female; Follow-Up Studies; Hum

2015
Decreased thalamic glutamate level in unmedicated adult obsessive-compulsive disorder patients detected by proton magnetic resonance spectroscopy.
    Journal of affective disorders, 2015, Jun-01, Volume: 178

    Topics: Adult; Case-Control Studies; Confounding Factors, Epidemiologic; Creatine; Female; Glutamic Acid; Hu

2015
A 1H magnetic resonance spectroscopy study in adults with obsessive compulsive disorder: relationship between metabolite concentrations and symptom severity.
    Journal of neural transmission (Vienna, Austria : 1996), 2008, Volume: 115, Issue:7

    Topics: Adult; Aspartic Acid; Brain; Brain Mapping; Case-Control Studies; Choline; Creatine; Female; Glutami

2008
Neurochemistry of the hippocampus in patients with obsessive-compulsive disorder.
    Psychiatry and clinical neurosciences, 2009, Volume: 63, Issue:4

    Topics: Adult; Analysis of Variance; Aspartic Acid; Brain; Choline; Creatine; Female; Functional Laterality;

2009
Increased N-Acetylaspartate/creatine ratio in the medial prefrontal cortex among unmedicated obsessive-compulsive disorder patients.
    Psychiatry and clinical neurosciences, 2010, Volume: 64, Issue:5

    Topics: Adolescent; Adult; Aspartic Acid; Choline; Creatine; Diagnostic and Statistical Manual of Mental Dis

2010
Brain magnetic resonance spectroscopy in obsessive-compulsive disorder: the importance of considering subclinical symptoms of anxiety and depression.
    Psychiatry research, 2011, Apr-30, Volume: 192, Issue:1

    Topics: Adult; Anxiety; Aspartic Acid; Brain; Brain Mapping; Choline; Creatine; Depression; Female; Function

2011
The involvement of distinct neural systems in patients with obsessive-compulsive disorder with autogenous and reactive obsessions.
    Acta psychiatrica Scandinavica, 2011, Volume: 124, Issue:2

    Topics: Adult; Aspartic Acid; Choline; Creatine; Diagnostic and Statistical Manual of Mental Disorders; Drug

2011
Proton magnetic resonance spectroscopy in pediatric obsessive-compulsive disorder: longitudinal study before and after treatment.
    Psychiatry research, 2012, Jan-30, Volume: 201, Issue:1

    Topics: Adolescent; Aspartic Acid; Behavior Therapy; Brain; Child; Choline; Creatine; Female; Follow-Up Stud

2012
Relevance of orbitofrontal neurochemistry for the outcome of cognitive-behavioural therapy in patients with obsessive-compulsive disorder.
    European archives of psychiatry and clinical neuroscience, 2012, Volume: 262, Issue:7

    Topics: Adolescent; Adult; Aged; Aspartic Acid; Cognitive Behavioral Therapy; Creatine; Female; Humans; Magn

2012
Reduced anterior cingulate glutamatergic concentrations in childhood OCD and major depression versus healthy controls.
    Journal of the American Academy of Child and Adolescent Psychiatry, 2004, Volume: 43, Issue:9

    Topics: Adolescent; Aspartic Acid; Child; Choline; Creatine; Depressive Disorder, Major; Female; Glutamic Ac

2004
Increased medial thalamic creatine-phosphocreatine found by proton magnetic resonance spectroscopy in children with obsessive-compulsive disorder versus major depression and healthy controls.
    Journal of child neurology, 2006, Volume: 21, Issue:2

    Topics: Adolescent; Brain Mapping; Child; Creatine; Depressive Disorder, Major; Dominance, Cerebral; Energy

2006
A proton MRSI study of brain N-acetylaspartate level after 12 weeks of citalopram treatment in drug-naive patients with obsessive-compulsive disorder.
    The American journal of psychiatry, 2006, Volume: 163, Issue:7

    Topics: Adult; Aspartic Acid; Brain; Brain Chemistry; Choline; Citalopram; Creatine; Female; Frontal Lobe; G

2006
Parietal white matter abnormalities in obsessive-compulsive disorder: a magnetic resonance spectroscopy study at 3-Tesla.
    Acta psychiatrica Scandinavica, 2006, Volume: 114, Issue:2

    Topics: Adolescent; Adult; Aspartic Acid; Choline; Creatine; Female; Humans; Magnetic Resonance Spectroscopy

2006
Proton magnetic resonance spectroscopy in obsessive-compulsive disorder: a pilot investigation comparing treatment responders and non-responders.
    Psychiatry research, 2007, Nov-15, Volume: 156, Issue:2

    Topics: Adult; Aspartic Acid; Basal Ganglia; Choline; Creatine; Dominance, Cerebral; Energy Metabolism; Fema

2007
Dopamine transporter genotype influences N-acetyl-aspartate in the left putamen.
    The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry, 2009, Volume: 10, Issue:4 Pt 2

    Topics: Adult; Aspartic Acid; Bipolar Disorder; Choline; Creatine; Dominance, Cerebral; Dopamine Plasma Memb

2009
Anterior cingulate glutamate-glutamine levels predict symptom severity in women with obsessive-compulsive disorder.
    The Australian and New Zealand journal of psychiatry, 2008, Volume: 42, Issue:6

    Topics: Adult; Aspartic Acid; Biomarkers; Choline; Creatine; Female; Glutamic Acid; Glutamine; Gyrus Cinguli

2008
Proton magnetic resonance spectroscopy of lenticular nuclei in obsessive-compulsive disorder.
    Psychiatry research, 1999, Dec-20, Volume: 92, Issue:2-3

    Topics: Adult; Analysis of Variance; Aspartame; Basal Ganglia; Choline; Corpus Striatum; Creatine; Female; H

1999
Proton spectroscopic imaging of the thalamus in treatment-naive pediatric obsessive-compulsive disorder.
    Biological psychiatry, 2000, Feb-01, Volume: 47, Issue:3

    Topics: Adolescent; Aspartic Acid; Brain Mapping; Case-Control Studies; Cerebral Cortex; Child; Choline; Cor

2000
Increased medial thalamic choline in pediatric obsessive-compulsive disorder as detected by quantitative in vivo spectroscopic imaging.
    Journal of child neurology, 2001, Volume: 16, Issue:9

    Topics: Adolescent; Aspartic Acid; Brain Mapping; Case-Control Studies; Child; Choline; Creatine; Cytosol; D

2001