creatine has been researched along with Neurofibromatosis 1 in 4 studies
Neurofibromatosis 1: An autosomal dominant inherited disorder (with a high frequency of spontaneous mutations) that features developmental changes in the nervous system, muscles, bones, and skin, most notably in tissue derived from the embryonic NEURAL CREST. Multiple hyperpigmented skin lesions and subcutaneous tumors are the hallmark of this disease. Peripheral and central nervous system neoplasms occur frequently, especially OPTIC NERVE GLIOMA and NEUROFIBROSARCOMA. NF1 is caused by mutations which inactivate the NF1 gene (GENES, NEUROFIBROMATOSIS 1) on chromosome 17q. The incidence of learning disabilities is also elevated in this condition. (From Adams et al., Principles of Neurology, 6th ed, pp1014-18) There is overlap of clinical features with NOONAN SYNDROME in a syndrome called neurofibromatosis-Noonan syndrome. Both the PTPN11 and NF1 gene products are involved in the SIGNAL TRANSDUCTION pathway of Ras (RAS PROTEINS).
| Excerpt | Relevance | Reference |
|---|---|---|
| "(a) Hamartomas showed higher N-acetyl aspartate/creatine, creatine/choline, and N-acetyl aspartate/choline ratios than gliomas." | 3.69 | Proton MR spectroscopy in patients with neurofibromatosis type 1: evaluation of hamartomas and clinical correlation. ( Castillo, M; Green, C; Greenwood, R; Kwock, L; Schiro, S; Smith, K; Wilson, D, 1995) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 3 (75.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (25.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Rodrigues, AC | 1 |
| Ferraz-Filho, JR | 1 |
| Torres, US | 1 |
| da Rocha, AJ | 1 |
| Muniz, MP | 1 |
| Souza, AS | 1 |
| Goloni-Bertollo, EM | 1 |
| Pavarino, ÉC | 1 |
| Castillo, M | 1 |
| Green, C | 1 |
| Kwock, L | 1 |
| Smith, K | 1 |
| Wilson, D | 1 |
| Schiro, S | 1 |
| Greenwood, R | 1 |
| Broniscer, A | 1 |
| Gajjar, A | 1 |
| Bhargava, R | 1 |
| Langston, JW | 1 |
| Heideman, R | 1 |
| Jones, D | 1 |
| Kun, LE | 1 |
| Taylor, J | 1 |
| Gonen, O | 1 |
| Wang, ZJ | 1 |
| Viswanathan, AK | 1 |
| Molloy, PT | 1 |
| Zimmerman, RA | 1 |
1 review available for creatine and Neurofibromatosis 1
| Article | Year |
|---|---|
Brain stem involvement in children with neurofibromatosis type 1: role of magnetic resonance imaging and spectroscopy in the distinction from diffuse pontine glioma.
Topics: Adolescent; Aspartic Acid; Brain Neoplasms; Brain Stem; Child; Child, Preschool; Choline; Creatine; | 1997 |
3 other studies available for creatine and Neurofibromatosis 1
| Article | Year |
|---|---|
Is magnetic resonance spectroscopy capable of detecting metabolic abnormalities in neurofibromatosis type 1 that are not revealed in brain parenchyma of normal appearance?
Topics: Adolescent; Aspartic Acid; Brain; Case-Control Studies; Child; Child, Preschool; Choline; Creatine; | 2015 |
Proton MR spectroscopy in patients with neurofibromatosis type 1: evaluation of hamartomas and clinical correlation.
Topics: Adolescent; Adult; Aspartic Acid; Astrocytoma; Brain; Brain Diseases; Brain Neoplasms; Cerebellar Di | 1995 |
Three-dimensional multivoxel proton MR spectroscopy of the brain in children with neurofibromatosis type 1.
Topics: Aspartic Acid; Brain; Brain Chemistry; Brain Neoplasms; Child; Child, Preschool; Choline; Creatine; | 1999 |