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creatine and Nerve Degeneration

creatine has been researched along with Nerve Degeneration in 29 studies

Nerve Degeneration: Loss of functional activity and trophic degeneration of nerve axons and their terminal arborizations following the destruction of their cells of origin or interruption of their continuity with these cells. The pathology is characteristic of neurodegenerative diseases. Often the process of nerve degeneration is studied in research on neuroanatomical localization and correlation of the neurophysiology of neural pathways.

Research Excerpts

ExcerptRelevanceReference
"The authors examined the levels of NAA, creatine plus phosphocreatine, and choline-containing molecules in the left dorsolateral prefrontal cortex of 14 bipolar disorder patients (mean age=15."3.73Reduced NAA levels in the dorsolateral prefrontal cortex of young bipolar patients. ( Axelson, D; Birmaher, B; Brambilla, P; Keshavan, MS; Nicoletti, MA; Ramos, RT; Ryan, N; Sassi, RB; Soares, JC; Stanley, JA, 2005)
"Autosomal-dominant spinocerebellar ataxia type 1 (SCA1) is an adult-onset progressive disorder with well-characterized neurodegeneration in the cerebellum and brainstem."1.40Metabolic evidence for cerebral neurodegeneration in spinocerebellar ataxia type 1. ( Brandt, AU; Doss, S; Endres, M; Oberwahrenbrock, T; Paul, F; Rinnenthal, JL, 2014)
"We used a mouse model of transient middle cerebral artery occlusion."1.35In vivo neuroprotection by a creatine-derived compound: phosphocreatine-Mg-complex acetate. ( Adriano, E; Balestrino, M; Burov, SV; Gandolfo, C; Perasso, L; Ruggeri, P, 2009)
"Creatine-treated subjects had significantly smaller ABR threshold shifts on day 1 and on day 10."1.34Creatine and tempol attenuate noise-induced hearing loss. ( Miller, JM; Minami, SB; Ogawa, K; Schacht, J; Yamashita, D, 2007)
"The study included 12 patients with progressive supranuclear palsy, 10 with Parkinson's disease, nine with corticobasal degeneration and 11 age-matched normal control subjects."1.30Proton magnetic resonance spectroscopic imaging in progressive supranuclear palsy, Parkinson's disease and corticobasal degeneration. ( Bertolino, A; Bonavita, S; Hallett, M; Litvan, I; Lundbom, N; Patronas, NJ; Tedeschi, G, 1997)
"Four grades of demyelination and three grades of cerebral atrophy were distinguished by magnetic resonance imaging criteria."1.281H and 31P magnetic resonance spectroscopy of the brain in degenerative cerebral disorders. ( den Hollander, JA; Luyten, PR; Nauta, JJ; Valk, J; van der Grond, J; van der Knaap, MS, 1992)

Research

Studies (29)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's9 (31.03)18.2507
2000's15 (51.72)29.6817
2010's5 (17.24)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Doss, S1
Brandt, AU1
Oberwahrenbrock, T1
Endres, M1
Paul, F1
Rinnenthal, JL1
Erichsen, AK1
Server, A1
Landrø, NI1
Sandvik, L1
Tallaksen, CM1
Rákóczi, K1
Klivényi, P2
Vécsei, L1
Perasso, L1
Adriano, E1
Ruggeri, P1
Burov, SV1
Gandolfo, C1
Balestrino, M1
Atmaca, M1
Yildirim, H1
Ozdemir, H1
Koc, M1
Ozler, S1
Tezcan, E1
Qian, J1
Herrera, JJ1
Narayana, PA1
Xu, W1
Zhan, Y1
Huang, W1
Wang, X1
Zhang, S1
Lei, H1
Brockmann, K1
Hilker, R1
Pilatus, U1
Baudrexel, S1
Srulijes, K1
Magerkurth, J1
Hauser, AK1
Schulte, C1
Csoti, I1
Merten, CD1
Gasser, T1
Berg, D1
Hattingen, E1
Davydovskaia, MV1
Boĭko, AN1
Podoprigora, AE1
Pronin, IN1
Kornienko, VN1
Gusev, EI1
Calingasan, NY1
Starkov, A1
Stavrovskaya, IG1
Kristal, BS1
Yang, L1
Wieringa, B1
Beal, MF1
Lodi, R1
Tonon, C1
Vignatelli, L1
Iotti, S1
Montagna, P1
Barbiroli, B1
Plazzi, G1
Sassi, RB1
Stanley, JA1
Axelson, D1
Brambilla, P1
Nicoletti, MA1
Keshavan, MS1
Ramos, RT1
Ryan, N1
Birmaher, B1
Soares, JC1
Boucard, CC1
Hoogduin, JM1
van der Grond, J2
Cornelissen, FW1
Minami, SB1
Yamashita, D1
Ogawa, K1
Schacht, J1
Miller, JM1
Funchal, C1
Tramontina, F1
Quincozes dos Santos, A1
Fraga de Souza, D1
Gonçalves, CA1
Pessoa-Pureur, R1
Wajner, M1
Casey, PA1
McKenna, MC1
Fiskum, G1
Saraswati, M1
Robertson, CL1
Rango, M1
Spagnoli, D1
Tomei, G1
Bamonti, F1
Scarlato, G1
Zetta, L1
Ohara, I1
Tabuchi, R1
Kimura, M1
Itokawa, Y1
Choe, BY1
Suh, TS1
Choi, KH1
Shinn, KS1
Park, CK1
Kang, JK1
Tedeschi, G2
Bertolino, A2
Massaquoi, SG1
Campbell, G1
Patronas, NJ2
Bonavita, S2
Barnett, AS1
Alger, JR1
Hallett, M2
Maier, M2
Ron, MA2
Barker, GJ1
Tofts, PS1
Litvan, I1
Lundbom, N1
Deicken, RF1
Zhou, L1
Schuff, N1
Weiner, MW1
Simone, IL1
Tortorella, C1
Federico, F1
Liguori, M1
Lucivero, V1
Giannini, P1
Carrara, D1
Bellacosa, A1
Livrea, P1
Khiat, A1
Yared, Z1
Bard, C1
Lacroix, A1
Boulanger, Y1
Massieu, L1
Del Río, P1
Montiel, T1
Murata, T1
Kimura, H1
Omori, M1
Kado, H1
Kosaka, H1
Iidaka, T1
Itoh, H1
Wada, Y1
van der Knaap, MS1
Luyten, PR1
den Hollander, JA1
Nauta, JJ1
Valk, J1

Reviews

1 review available for creatine and Nerve Degeneration

ArticleYear
[Neuroprotection in Parkinson's disease and other neurodegenerative disorders: preclinical and clinical findings].
    Ideggyogyaszati szemle, 2009, Jan-30, Volume: 62, Issue:1-2

    Topics: Animals; Creatine; Dopamine Agonists; Glatiramer Acetate; Humans; Indans; Kynurenic Acid; Micronutri

2009

Other Studies

28 other studies available for creatine and Nerve Degeneration

ArticleYear
Metabolic evidence for cerebral neurodegeneration in spinocerebellar ataxia type 1.
    Cerebellum (London, England), 2014, Volume: 13, Issue:2

    Topics: Adult; Aged; Analysis of Variance; Aspartic Acid; Brain; Cerebral Cortex; Choline; Creatine; Female;

2014
Proton magnetic resonance spectroscopy and cognition in patients with spastin mutations.
    Journal of the neurological sciences, 2009, Feb-15, Volume: 277, Issue:1-2

    Topics: Adenosine Triphosphatases; Adult; Aspartic Acid; Biomarkers; Choline; Cognition Disorders; Creatine;

2009
In vivo neuroprotection by a creatine-derived compound: phosphocreatine-Mg-complex acetate.
    Brain research, 2009, Aug-18, Volume: 1285

    Topics: Animals; Brain Infarction; Brain Ischemia; Creatine; Cytoprotection; Disease Models, Animal; Infarct

2009
Neurochemistry of the hippocampus in patients with obsessive-compulsive disorder.
    Psychiatry and clinical neurosciences, 2009, Volume: 63, Issue:4

    Topics: Adult; Analysis of Variance; Aspartic Acid; Brain; Choline; Creatine; Female; Functional Laterality;

2009
Neuronal and axonal degeneration in experimental spinal cord injury: in vivo proton magnetic resonance spectroscopy and histology.
    Journal of neurotrauma, 2010, Volume: 27, Issue:3

    Topics: Animals; Aspartic Acid; Choline; Creatine; Disease Models, Animal; Disease Progression; Gliosis; Imm

2010
Reduction of hippocampal N-acetyl aspartate level in aged APP(Swe)/PS1(dE9) transgenic mice is associated with degeneration of CA3 pyramidal neurons.
    Journal of neuroscience research, 2010, Nov-01, Volume: 88, Issue:14

    Topics: Aging; Alzheimer Disease; Amyloid beta-Protein Precursor; Animals; Aspartic Acid; Benzothiazoles; CA

2010
GBA-associated PD. Neurodegeneration, altered membrane metabolism, and lack of energy failure.
    Neurology, 2012, Jul-17, Volume: 79, Issue:3

    Topics: Adenosine Diphosphate; Adult; Age of Onset; Aged; Algorithms; Aspartic Acid; Brain Chemistry; Cholin

2012
[The neurodegenerative process in multiple sclerosis and the possible neuroprotective effect of treatment with Β-interferon 1a (avonex)].
    Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova, 2012, Volume: 112, Issue:7

    Topics: Adolescent; Adult; Aspartic Acid; Brain Chemistry; Creatine; Female; Humans; Interferon beta-1a; Int

2012
Neuroprotective mechanisms of creatine occur in the absence of mitochondrial creatine kinase.
    Neurobiology of disease, 2004, Volume: 15, Issue:3

    Topics: 3,4-Dihydroxyphenylacetic Acid; Adenosine Monophosphate; Animals; Brain; Brain Chemistry; Chromatogr

2004
In vivo evidence of neuronal loss in the hypothalamus of narcoleptic patients.
    Neurology, 2004, Oct-26, Volume: 63, Issue:8

    Topics: Adolescent; Adult; Aged; Aspartic Acid; Atrophy; Cataplexy; Creatine; Female; Humans; Hypothalamus;

2004
Reduced NAA levels in the dorsolateral prefrontal cortex of young bipolar patients.
    The American journal of psychiatry, 2005, Volume: 162, Issue:11

    Topics: Adolescent; Adult; Age Factors; Aspartic Acid; Bipolar Disorder; Child; Choline; Creatine; Female; H

2005
Occipital proton magnetic resonance spectroscopy (1H-MRS) reveals normal metabolite concentrations in retinal visual field defects.
    PloS one, 2007, Feb-21, Volume: 2, Issue:2

    Topics: Aged; Aged, 80 and over; Aspartic Acid; Biomarkers; Choline; Creatine; Female; Glaucoma; Humans; Mac

2007
Creatine and tempol attenuate noise-induced hearing loss.
    Brain research, 2007, May-07, Volume: 1148

    Topics: Adenosine Triphosphate; Animals; Antioxidants; Auditory Threshold; Cochlea; Creatine; Cyclic N-Oxide

2007
Effect of the branched-chain alpha-keto acids accumulating in maple syrup urine disease on S100B release from glial cells.
    Journal of the neurological sciences, 2007, Sep-15, Volume: 260, Issue:1-2

    Topics: Animals; Brain; Cell Death; Cell Line, Tumor; Creatine; Dose-Response Relationship, Drug; Energy Met

2007
Early and sustained alterations in cerebral metabolism after traumatic brain injury in immature rats.
    Journal of neurotrauma, 2008, Volume: 25, Issue:6

    Topics: Aging; Alanine; Animals; Animals, Newborn; Aspartic Acid; Brain; Brain Injuries; Cell Respiration; C

2008
Central nervous system trans-synaptic effects of acute axonal injury: a 1H magnetic resonance spectroscopy study.
    Magnetic resonance in medicine, 1995, Volume: 33, Issue:5

    Topics: Animals; Aspartic Acid; Axons; Creatine; Female; Geniculate Bodies; Guinea Pigs; Magnetic Resonance

1995
Decline of taste sensitivity in protein deficient adult rats.
    Physiology & behavior, 1995, Volume: 57, Issue:5

    Topics: Age Factors; Animals; Creatine; Female; Food Preferences; Glomerular Filtration Rate; Microscopy, El

1995
Neuronal dysfunction in patients with closed head injury evaluated by in vivo 1H magnetic resonance spectroscopy.
    Investigative radiology, 1995, Volume: 30, Issue:8

    Topics: Algorithms; Aspartic Acid; Cerebral Cortex; Choline; Creatine; Energy Metabolism; Glasgow Coma Scale

1995
Proton magnetic resonance spectroscopic imaging in patients with cerebellar degeneration.
    Annals of neurology, 1996, Volume: 39, Issue:1

    Topics: Adult; Aged; Aspartic Acid; Atrophy; Cerebellar Diseases; Cerebellum; Choline; Creatine; Humans; Lac

1996
Proton magnetic resonance spectroscopy: an in vivo method of estimating hippocampal neuronal depletion in schizophrenia.
    Psychological medicine, 1995, Volume: 25, Issue:6

    Topics: Adult; Choline Deficiency; Creatine; Female; Functional Laterality; Hippocampus; Humans; Magnetic Re

1995
Hippocampal age-related changes in schizophrenia: a proton magnetic resonance spectroscopy study.
    Schizophrenia research, 1996, Oct-18, Volume: 22, Issue:1

    Topics: Adolescent; Adult; Age Factors; Aging; Aspartic Acid; Choline; Creatine; Female; Functional Laterali

1996
Proton magnetic resonance spectroscopic imaging in progressive supranuclear palsy, Parkinson's disease and corticobasal degeneration.
    Brain : a journal of neurology, 1997, Volume: 120 ( Pt 9)

    Topics: Aged; Aged, 80 and over; Aspartic Acid; Brain; Brain Diseases; Choline; Creatine; Female; Humans; Ma

1997
Proton magnetic resonance spectroscopy of the anterior cingulate region in schizophrenia.
    Schizophrenia research, 1997, Oct-17, Volume: 27, Issue:1

    Topics: Adult; Antipsychotic Agents; Aspartic Acid; Brain Mapping; Choline; Creatine; Dominance, Cerebral; F

1997
Axonal damage in multiple sclerosis plaques: a combined magnetic resonance imaging and 1H-magnetic resonance spectroscopy study.
    Journal of the neurological sciences, 2001, Jan-01, Volume: 182, Issue:2

    Topics: Adolescent; Adult; Aspartic Acid; Axons; Brain; Choline; Creatine; Female; Humans; Lactic Acid; Magn

2001
Long-term brain metabolic alterations in exogenous Cushing's syndrome as monitored by proton magnetic resonance spectroscopy.
    Brain research, 2001, Aug-24, Volume: 911, Issue:2

    Topics: Adult; Aspartic Acid; Brain; Brain Diseases, Metabolic; Brain Injuries; Cell Membrane; Choline; Crea

2001
Neurotoxicity of glutamate uptake inhibition in vivo: correlation with succinate dehydrogenase activity and prevention by energy substrates.
    Neuroscience, 2001, Volume: 106, Issue:4

    Topics: 3-Hydroxybutyric Acid; Acetoacetates; Amino Acid Transport System X-AG; Animals; Brain Ischemia; Con

2001
MRI white matter hyperintensities, (1)H-MR spectroscopy and cognitive function in geriatric depression: a comparison of early- and late-onset cases.
    International journal of geriatric psychiatry, 2001, Volume: 16, Issue:12

    Topics: Aged; Alzheimer Disease; Aspartic Acid; Brain; Choline; Creatine; Depressive Disorder, Major; Energy

2001
1H and 31P magnetic resonance spectroscopy of the brain in degenerative cerebral disorders.
    Annals of neurology, 1992, Volume: 31, Issue:2

    Topics: Adult; Aspartic Acid; Atrophy; Brain; Brain Diseases; Child; Creatine; Demyelinating Diseases; Human

1992