creatine has been researched along with Myocardial Ischemia in 31 studies
Myocardial Ischemia: A disorder of cardiac function caused by insufficient blood flow to the muscle tissue of the heart. The decreased blood flow may be due to narrowing of the coronary arteries (CORONARY ARTERY DISEASE), to obstruction by a thrombus (CORONARY THROMBOSIS), or less commonly, to diffuse narrowing of arterioles and other small vessels within the heart. Severe interruption of the blood supply to the myocardial tissue may result in necrosis of cardiac muscle (MYOCARDIAL INFARCTION).
| Excerpt | Relevance | Reference |
|---|---|---|
| "Randomized controlled trials comparing creatine, creatine phosphate, or cyclocreatine (any route, dose or duration of treatment) with placebo; in adult patients with essential hypertension, heart failure, or myocardial infarction." | 8.87 | Creatine and creatine analogues in hypertension and cardiovascular disease. ( Brewster, LM; Horjus, DL; Oudman, I; van Montfrans, GA, 2011) |
| "Randomized controlled trials comparing creatine, creatine phosphate, or cyclocreatine (any route, dose or duration of treatment) with placebo; in adult patients with essential hypertension, heart failure, or myocardial infarction." | 4.87 | Creatine and creatine analogues in hypertension and cardiovascular disease. ( Brewster, LM; Horjus, DL; Oudman, I; van Montfrans, GA, 2011) |
| "The aim of this study is to establish whether a supplement of creatine and ribose combined with a physical exercise program can improve the total work capacity during exercise in a population of patients with known ischemic heart disease." | 2.90 | A Randomized, Double-Blind, Placebo-Controlled Study to Evaluate the Effectiveness of a Food Supplement Containing Creatine and D-Ribose Combined with a Physical Exercise Program in Increasing Stress Tolerance in Patients with Ischemic Heart Disease. ( Catena, G; D'Angelo, A; Derosa, G; Maffioli, P; Maggi, A; Pasqualotto, S, 2019) |
| "Phosphocreatine (PCr) has been administered after human MI, where it proved to be safe and probably helpful." | 2.49 | Therapeutic use of creatine in brain or heart ischemia: available data and future perspectives. ( Balestrino, M; Gandolfo, C; Perasso, L; Ruggeri, P; Spallarossa, P, 2013) |
| "The pharmacokinetic (PK) studies of phosphocreatine (PCr) and its active metabolite creatine (Cr) are considerably lacking." | 1.40 | Pharmacokinetics of phosphocreatine and its active metabolite creatine in the mouse plasma and myocardium. ( Han, GZ; Liu, KX; Lv, L; Sun, HJ; Wang, CY; Xu, L, 2014) |
| "Subjects with the metabolic syndrome are significantly more likely to have higher BMI (> 25 kg/m(2)), HbA(1c) [≥ 42 mmol/mol (6." | 1.38 | Predictors of ischaemic heart disease in a Malaysian population with the metabolic syndrome. ( Azwany, YN; Bebakar, WM; Ismail, AA; Ismail, IS; Kamaruddin, NA; Kamarul Imran, M; Khalid, BA; Khir, AS; Md Isa, SH; Mustafa, N; Nazaimoon, WM; Osman, A; Yeow, TP, 2012) |
| "A total of 201 patients with IDDM for more than 10 years and 159 patients with IDDM for more than 15 years were randomly selected in our hospital." | 1.30 | Genetic polymorphism of renin-angiotensin system is not associated with diabetic vascular complications in Japanese subjects with long-term insulin dependent diabetes mellitus. ( Iwamoto, Y; Miura, J; Omori, Y; Uchigata, Y; Yokoyama, H, 1999) |
| "Hypoxanthine excretion was significantly elevated in patients compared with healthy controls (84." | 1.30 | Urinary hypoxanthine and xanthine levels in acute coronary syndromes. ( Bayindir, O; Boydak, B; Gülter, C; Habif, S; Mutaf, I; Ozmen, D; Senol, B; Turgan, N, 1999) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 14 (45.16) | 18.2507 |
| 2000's | 11 (35.48) | 29.6817 |
| 2010's | 6 (19.35) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Derosa, G | 1 |
| Pasqualotto, S | 1 |
| Catena, G | 1 |
| D'Angelo, A | 1 |
| Maggi, A | 1 |
| Maffioli, P | 1 |
| Xu, L | 1 |
| Wang, CY | 1 |
| Lv, L | 1 |
| Liu, KX | 1 |
| Sun, HJ | 1 |
| Han, GZ | 1 |
| Horjus, DL | 1 |
| Oudman, I | 1 |
| van Montfrans, GA | 1 |
| Brewster, LM | 1 |
| Perasso, L | 1 |
| Spallarossa, P | 1 |
| Gandolfo, C | 1 |
| Ruggeri, P | 1 |
| Balestrino, M | 1 |
| Yeow, TP | 1 |
| Khir, AS | 1 |
| Ismail, AA | 1 |
| Ismail, IS | 1 |
| Kamarul Imran, M | 1 |
| Khalid, BA | 1 |
| Kamaruddin, NA | 1 |
| Azwany, YN | 1 |
| Mustafa, N | 1 |
| Osman, A | 1 |
| Md Isa, SH | 1 |
| Bebakar, WM | 1 |
| Nazaimoon, WM | 1 |
| Persson, PB | 1 |
| Taes, YE | 1 |
| Lameire, NH | 1 |
| De Buyzere, ML | 1 |
| Shoja, A | 1 |
| De Backer, G | 1 |
| Delanghe, JR | 1 |
| Nakae, I | 2 |
| Mitsunami, K | 2 |
| Omura, T | 1 |
| Yabe, T | 2 |
| Tsutamoto, T | 1 |
| Matsuo, S | 2 |
| Takahashi, M | 1 |
| Morikawa, S | 2 |
| Inubushi, T | 2 |
| Nakamura, Y | 1 |
| Kinoshita, M | 1 |
| Horie, M | 2 |
| Koh, T | 1 |
| Blunt, BC | 1 |
| Chen, Y | 1 |
| Potter, JD | 1 |
| Hofmann, PA | 1 |
| Michailova, A | 1 |
| Lorentz, W | 1 |
| McCulloch, A | 1 |
| Omar, MA | 1 |
| Fraser, H | 1 |
| Clanachan, AS | 1 |
| Ogino, H | 1 |
| Smolenski, RT | 3 |
| Seymour, AM | 1 |
| Yacoub, MH | 3 |
| Veksler, V | 1 |
| Ventura-Clapier, R | 1 |
| Osbakken, MD | 1 |
| Wroblewski, K | 1 |
| Zhang, D | 1 |
| Ivanics, T | 1 |
| Wehrli, S | 1 |
| Kobara, M | 1 |
| Tatsumi, T | 1 |
| Matoba, S | 1 |
| Yamahara, Y | 1 |
| Nakagawa, C | 1 |
| Ohta, B | 1 |
| Matsumoto, T | 1 |
| Inoue, D | 1 |
| Asayama, J | 1 |
| Nakagawa, M | 1 |
| Altschuld, RA | 1 |
| Pisarenko, OI | 1 |
| Tskitishvily, OV | 1 |
| Studneva, IM | 1 |
| Serebryakova, LI | 1 |
| Korchazhkina, OV | 1 |
| Askenasy, N | 1 |
| Navon, G | 1 |
| Kay, L | 2 |
| Rossi, A | 2 |
| Saks, V | 1 |
| Saks, VA | 2 |
| Gray, C | 1 |
| Jayakumar, J | 1 |
| Amrani, M | 2 |
| Tune, JD | 1 |
| Mallet, RT | 1 |
| Downey, HF | 1 |
| Allibardi, S | 1 |
| Merati, G | 1 |
| Chierchia, S | 1 |
| Samaja, M | 1 |
| Miura, J | 1 |
| Uchigata, Y | 1 |
| Yokoyama, H | 1 |
| Omori, Y | 1 |
| Iwamoto, Y | 1 |
| Turgan, N | 1 |
| Boydak, B | 1 |
| Habif, S | 1 |
| Gülter, C | 1 |
| Senol, B | 1 |
| Mutaf, I | 1 |
| Ozmen, D | 1 |
| Bayindir, O | 1 |
| Peart, J | 1 |
| Headrick, JP | 1 |
| Tian, R | 1 |
| Abel, ED | 1 |
| Gray, CC | 1 |
| Taylor, GL | 1 |
| Boudina, S | 2 |
| Laclau, MN | 2 |
| Tariosse, L | 2 |
| Daret, D | 1 |
| Gouverneur, G | 1 |
| Bonoron-Adèle, S | 1 |
| Dos Santos, P | 2 |
| Kowaltowski, AJ | 1 |
| Seetharaman, S | 1 |
| Paucek, P | 1 |
| Thambo, JB | 1 |
| Garlid, KD | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Myocardial Protection With Phosphocreatine in High-RIsk Cardiac SurgEry Patients: a Single-center Randomised Double-blind Placebo-controlled Exploratory Pilot Clinical Trial[NCT02757443] | Phase 3 | 120 participants (Actual) | Interventional | 2016-06-30 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
3 reviews available for creatine and Myocardial Ischemia
| Article | Year |
|---|---|
Creatine and creatine analogues in hypertension and cardiovascular disease.
Topics: Cardiovascular Diseases; Creatine; Creatine Kinase; Heart Failure; Humans; Hypertension; Molecular T | 2011 |
Therapeutic use of creatine in brain or heart ischemia: available data and future perspectives.
Topics: Blood-Brain Barrier; Brain Ischemia; Cardiotonic Agents; Creatine; Female; Forecasting; Humans; In V | 2013 |
Intracellular calcium regulatory systems during ischemia and reperfusion.
Topics: Adenosine Triphosphate; Animals; Calcium; Creatine; Homeostasis; Humans; Intracellular Fluid; Ion Tr | 1996 |
2 trials available for creatine and Myocardial Ischemia
| Article | Year |
|---|---|
A Randomized, Double-Blind, Placebo-Controlled Study to Evaluate the Effectiveness of a Food Supplement Containing Creatine and D-Ribose Combined with a Physical Exercise Program in Increasing Stress Tolerance in Patients with Ischemic Heart Disease.
Topics: Aged; Creatine; Dietary Supplements; Double-Blind Method; Exercise; Exercise Test; Exercise Therapy; | 2019 |
Exercise-induced myocardial ischemia is accompanied by increased serum creatine concentrations.
Topics: Creatine; Electrocardiography; Exercise Test; Humans; Male; Middle Aged; Myocardial Ischemia | 2003 |
26 other studies available for creatine and Myocardial Ischemia
| Article | Year |
|---|---|
Pharmacokinetics of phosphocreatine and its active metabolite creatine in the mouse plasma and myocardium.
Topics: Adenosine Triphosphate; Animals; Chromatography, High Pressure Liquid; Creatine; Disease Models, Ani | 2014 |
Predictors of ischaemic heart disease in a Malaysian population with the metabolic syndrome.
Topics: Adult; Biomarkers; Body Mass Index; C-Reactive Protein; Cholesterol, LDL; Creatine; Cross-Sectional | 2012 |
Exercise and creatine supplementation attenuate recovery from myocardial ischaemia.
Topics: Animals; Creatine; Dietary Supplements; Exercise; Humans; Mitochondria, Heart; Myocardial Ischemia; | 2012 |
Proton magnetic resonance spectroscopy can detect creatine depletion associated with the progression of heart failure in cardiomyopathy.
Topics: Adult; Cardiomyopathy, Dilated; Creatine; Disease Progression; Female; Humans; Image Processing, Com | 2003 |
Detection of metabolic abnormality in asynergic regions of ischemic human myocardium using 31P and 1H magnetic resonance spectroscopy.
Topics: Adenosine Triphosphate; Adult; Aged; Analysis of Variance; Case-Control Studies; Creatine; Dyskinesi | 2004 |
Modest actomyosin energy conservation increases myocardial postischemic function.
Topics: Actomyosin; Adenine; Adenosine Triphosphatases; Adenosine Triphosphate; Animals; Calcium; Creatine; | 2005 |
Modeling transmural heterogeneity of K(ATP) current in rabbit ventricular myocytes.
Topics: Action Potentials; Adenosine Diphosphate; Adenosine Monophosphate; Adenosine Triphosphate; Animals; | 2007 |
Ischemia-induced activation of AMPK does not increase glucose uptake in glycogen-replete isolated working rat hearts.
Topics: Adenosine Monophosphate; Adenosine Triphosphate; Aerobiosis; Animals; Cell Membrane; Creatine; Cycli | 2008 |
The effect of ischemic preconditioning on nucleotide metabolism and function of rat heart after prolonged cold storage.
Topics: Adenine Nucleotides; Animals; Cold Temperature; Creatine; Diastole; Guanosine Triphosphate; Heart; I | 1994 |
Ischaemic metabolic factors-high inorganic phosphate and acidosis--modulate mitochondrial creatine kinase functional activity in skinned cardiac fibres.
Topics: Acidosis; Adenosine Diphosphate; Animals; Creatine; Creatine Kinase; Energy Metabolism; Hydrogen-Ion | 1994 |
31P relaxation rates to evaluate physiological events in the heart.
Topics: Adenosine Triphosphate; Animals; Catalase; Creatine; Creatinine; Diet; Female; Heart; Magnetic Reson | 1993 |
Effect of ischemic preconditioning on mitochondrial oxidative phosphorylation and high energy phosphates in rat hearts.
Topics: Adenosine Triphosphatases; Adenosine Triphosphate; Anaerobiosis; Animals; Creatine; Creatine Kinase; | 1996 |
Metabolic effects of ischemic preconditioning and adenosine receptor blockade in dogs.
Topics: Adenosine; Animals; Creatine; Dogs; Female; Lactic Acid; Male; Myocardial Ischemia; Purinergic P1 Re | 1996 |
Intermittent ischemia: energy metabolism, cellular volume regulation, adenosine and insights into preconditioning.
Topics: Adenosine; Animals; Cell Size; Creatine; Energy Metabolism; Glyburide; Glycogen; Glycolysis; In Vitr | 1997 |
Detection of early ischemic damage by analysis of mitochondrial function in skinned fibers.
Topics: Adenosine Diphosphate; Animals; Cell Membrane; Creatine; Cytoprotection; Electron Transport; Female; | 1997 |
Early alteration of the control of mitochondrial function in myocardial ischemia.
Topics: Adenosine Diphosphate; Animals; Creatine; Energy Metabolism; Male; Mitochondria, Heart; Myocardial I | 1997 |
Nucleotide metabolism in the heart subjected to heat stress.
Topics: Adenine Nucleotides; Animals; Creatine; Cytidine Triphosphate; Guanine Nucleotides; Guanosine Tripho | 1998 |
Insulin improves cardiac contractile function and oxygen utilization efficiency during moderate ischemia without compromising myocardial energetics.
Topics: Adenosine Triphosphate; Animals; Blood Glucose; Coronary Circulation; Coronary Vessels; Creatine; Do | 1998 |
Atenolol depresses post-ischaemic recovery in the isolated rat heart.
Topics: Adenine Nucleotides; Adenosine Triphosphate; Adrenergic beta-Antagonists; Analysis of Variance; Anim | 1999 |
Genetic polymorphism of renin-angiotensin system is not associated with diabetic vascular complications in Japanese subjects with long-term insulin dependent diabetes mellitus.
Topics: Adult; Albuminuria; Angiotensinogen; Blood Pressure; Cohort Studies; Creatine; Diabetes Mellitus, Ty | 1999 |
Urinary hypoxanthine and xanthine levels in acute coronary syndromes.
Topics: Acute Disease; Adult; Aged; Angina, Unstable; Biomarkers; Blood Urea Nitrogen; Creatine; Female; Hum | 1999 |
Intrinsic A(1) adenosine receptor activation during ischemia or reperfusion improves recovery in mouse hearts.
Topics: Adenosine; Adenosine Diphosphate; Adenosine Triphosphate; Animals; Creatine; Extracellular Space; He | 2000 |
Responses of GLUT4-deficient hearts to ischemia underscore the importance of glycolysis.
Topics: Adenosine Triphosphate; Animals; Blood Pressure; Creatine; Fasting; Glucose; Glucose Transporter Typ | 2001 |
Influence of age and heat stress on cardiac function and nucleotide levels.
Topics: Adenosine Triphosphate; Age Factors; Animals; Creatine; Heart; Heat-Shock Response; Heating; HSP70 H | 2000 |
Alteration of mitochondrial function in a model of chronic ischemia in vivo in rat heart.
Topics: Adenosine Diphosphate; Animals; Calcium; Coronary Circulation; Coronary Vessels; Creatine; Cytochrom | 2002 |
Mechanisms by which opening the mitochondrial ATP- sensitive K(+) channel protects the ischemic heart.
Topics: Adenosine Diphosphate; Adenosine Triphosphate; Animals; Cell Respiration; Creatine; Diazoxide; Hemod | 2002 |