creatine has been researched along with Motor Neuron Disease in 11 studies
Motor Neuron Disease: Diseases characterized by a selective degeneration of the motor neurons of the spinal cord, brainstem, or motor cortex. Clinical subtypes are distinguished by the major site of degeneration. In AMYOTROPHIC LATERAL SCLEROSIS there is involvement of upper, lower, and brainstem motor neurons. In progressive muscular atrophy and related syndromes (see MUSCULAR ATROPHY, SPINAL) the motor neurons in the spinal cord are primarily affected. With progressive bulbar palsy (BULBAR PALSY, PROGRESSIVE), the initial degeneration occurs in the brainstem. In primary lateral sclerosis, the cortical neurons are affected in isolation. (Adams et al., Principles of Neurology, 6th ed, p1089)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Creatine, a naturally-occurring nitrogenous organic acid involved in adenosine triphosphate (ATP) production, has been shown to increase survival in mouse models of amyotrophic lateral sclerosis (ALS), also known as motor neuron disease (MND)." | 8.88 | Creatine for amyotrophic lateral sclerosis/motor neuron disease. ( Bedlack, RS; Moore, DH; Pastula, DM, 2012) |
| "Creatine, a naturally-occurring nitrogenous organic acid involved in adenosine triphosphate (ATP) production, has been shown to increase survival in mouse models of amyotrophic lateral sclerosis (ALS)." | 8.86 | Creatine for amyotrophic lateral sclerosis/motor neuron disease. ( Bedlack, RS; Moore, DH; Pastula, DM, 2010) |
| "Creatine has a neuroprotective effect in mutant superoxide dismutase (G93A) transgenic mice, an animal model of motor neuron disease (MND)." | 7.70 | Oral administration of creatine monohydrate retards progression of motor neuron disease in the wobbler mouse. ( Ikeda, K; Iwasaki, Y; Kinoshita, M, 2000) |
| "Creatine, a naturally-occurring nitrogenous organic acid involved in adenosine triphosphate (ATP) production, has been shown to increase survival in mouse models of amyotrophic lateral sclerosis (ALS), also known as motor neuron disease (MND)." | 4.88 | Creatine for amyotrophic lateral sclerosis/motor neuron disease. ( Bedlack, RS; Moore, DH; Pastula, DM, 2012) |
| "Creatine, a naturally-occurring nitrogenous organic acid involved in adenosine triphosphate (ATP) production, has been shown to increase survival in mouse models of amyotrophic lateral sclerosis (ALS)." | 4.86 | Creatine for amyotrophic lateral sclerosis/motor neuron disease. ( Bedlack, RS; Moore, DH; Pastula, DM, 2010) |
| "Creatine has a neuroprotective effect in mutant superoxide dismutase (G93A) transgenic mice, an animal model of motor neuron disease (MND)." | 3.70 | Oral administration of creatine monohydrate retards progression of motor neuron disease in the wobbler mouse. ( Ikeda, K; Iwasaki, Y; Kinoshita, M, 2000) |
| "Amyotrophic lateral sclerosis (ALS), also known as motor neuron disease (MND), is a rare neurodegenerative disease." | 2.45 | Treatment for familial amyotrophic lateral sclerosis/motor neuron disease. ( Benatar, M; Kurent, J; Moore, DH, 2009) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (18.18) | 18.2507 |
| 2000's | 7 (63.64) | 29.6817 |
| 2010's | 2 (18.18) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Benatar, M | 1 |
| Kurent, J | 1 |
| Moore, DH | 3 |
| Pastula, DM | 2 |
| Bedlack, RS | 2 |
| Pascuzzi, RM | 1 |
| Wang, S | 1 |
| Poptani, H | 1 |
| Woo, JH | 1 |
| Desiderio, LM | 1 |
| Elman, LB | 1 |
| McCluskey, LF | 1 |
| Krejza, J | 1 |
| Melhem, ER | 1 |
| Mitsumoto, H | 2 |
| Ulug, AM | 1 |
| Pullman, SL | 1 |
| Gooch, CL | 1 |
| Chan, S | 2 |
| Tang, MX | 1 |
| Mao, X | 1 |
| Hays, AP | 1 |
| Floyd, AG | 1 |
| Battista, V | 1 |
| Montes, J | 1 |
| Hayes, S | 1 |
| Dashnaw, S | 1 |
| Kaufmann, P | 1 |
| Gordon, PH | 1 |
| Hirsch, J | 1 |
| Levin, B | 1 |
| Rowland, LP | 2 |
| Shungu, DC | 2 |
| Pioro, EP | 1 |
| Wang, Y | 1 |
| Moore, JK | 1 |
| Ng, TC | 1 |
| Trapp, BD | 1 |
| Klinkosz, B | 1 |
| Douglas-Akinwande, A | 1 |
| Lange, DJ | 1 |
| Schuff, N | 1 |
| Rooney, WD | 1 |
| Miller, R | 1 |
| Gelinas, DF | 1 |
| Amend, DL | 1 |
| Maudsley, AA | 1 |
| Weiner, MW | 1 |
| Andreassen, OA | 1 |
| Jenkins, BG | 1 |
| Dedeoglu, A | 1 |
| Ferrante, KL | 1 |
| Bogdanov, MB | 1 |
| Kaddurah-Daouk, R | 1 |
| Beal, MF | 1 |
| Ikeda, K | 1 |
| Iwasaki, Y | 1 |
| Kinoshita, M | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Nuclear Magnetic Spectroscopy for the Evaluation of Primary Lateral Sclerosis, Hereditary Spastic Paraplegia and Amyotrophic Lateral Sclerosis[NCT00023075] | 55 participants | Observational | 2001-08-31 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
4 reviews available for creatine and Motor Neuron Disease
| Article | Year |
|---|---|
Treatment for familial amyotrophic lateral sclerosis/motor neuron disease.
Topics: Amyotrophic Lateral Sclerosis; Anti-Inflammatory Agents, Non-Steroidal; Celecoxib; Creatine; Fructos | 2009 |
Creatine for amyotrophic lateral sclerosis/motor neuron disease.
Topics: Amyotrophic Lateral Sclerosis; Creatine; Disease Progression; Humans; Motor Neuron Disease; Neuropro | 2010 |
Creatine for amyotrophic lateral sclerosis/motor neuron disease.
Topics: Amyotrophic Lateral Sclerosis; Creatine; Disease Progression; Humans; Motor Neuron Disease; Neuropro | 2012 |
ALS, motor neuron disease, and related disorders: a personal approach to diagnosis and management.
Topics: Adolescent; Adult; Animals; Case Management; Combined Modality Therapy; Creatine; Diagnosis, Differe | 2002 |
7 other studies available for creatine and Motor Neuron Disease
| Article | Year |
|---|---|
Amyotrophic lateral sclerosis: diffusion-tensor and chemical shift MR imaging at 3.0 T.
Topics: Adult; Age Factors; Aged; Amyotrophic Lateral Sclerosis; Aspartic Acid; Choline; Creatine; Diffusion | 2006 |
Quantitative objective markers for upper and lower motor neuron dysfunction in ALS.
Topics: Adult; Aged; Aged, 80 and over; Amyotrophic Lateral Sclerosis; Aspartic Acid; Biomarkers; Creatine; | 2007 |
Neuronal pathology in the wobbler mouse brain revealed by in vivo proton magnetic resonance spectroscopy and immunocytochemistry.
Topics: Amyotrophic Lateral Sclerosis; Animals; Aspartic Acid; Axons; Caudate Nucleus; Creatine; Disease Mod | 1998 |
Motor neuron diseases: comparison of single-voxel proton MR spectroscopy of the motor cortex with MR imaging of the brain.
Topics: Aged; Amyotrophic Lateral Sclerosis; Aspartic Acid; Brain; Creatine; Female; Humans; Magnetic Resona | 1999 |
Reanalysis of multislice (1)H MRSI in amyotrophic lateral sclerosis.
Topics: Adult; Aged; Aspartic Acid; Brain; Choline; Creatine; Energy Metabolism; Female; Humans; Image Proce | 2001 |
Increases in cortical glutamate concentrations in transgenic amyotrophic lateral sclerosis mice are attenuated by creatine supplementation.
Topics: Amino Acid Transport System X-AG; Animals; ATP-Binding Cassette Transporters; Biological Transport; | 2001 |
Oral administration of creatine monohydrate retards progression of motor neuron disease in the wobbler mouse.
Topics: Administration, Oral; Animals; Cell Count; Creatine; Disease Models, Animal; Disease Progression; Fo | 2000 |