creatine has been researched along with Machado-Joseph Disease in 5 studies
Machado-Joseph Disease: A dominantly-inherited ATAXIA first described in people of Azorean and Portuguese descent, and subsequently identified in Brazil, Japan, China, and Australia. This disorder is classified as one of the SPINOCEREBELLAR ATAXIAS (Type 3) and has been associated with a mutation of the MJD1 gene on chromosome 14. Clinical features include progressive ataxia, DYSARTHRIA, postural instability, nystagmus, eyelid retraction, and facial FASCICULATIONS. DYSTONIA is prominent in younger patients (referred to as Type I Machado-Joseph Disease). Type II features ataxia and ocular signs; Type III features MUSCULAR ATROPHY and a sensorimotor neuropathy; and Type IV features extrapyramidal signs combined with a sensorimotor neuropathy. (From Clin Neurosci 1995;3(1):17-22; Ann Neurol 1998 Mar;43(3):288-96)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Creatine treatment also restored the expression of the mitochondrial mass marker Porin and reduced the expression of antioxidant enzymes Heme oxygenase 1 (HO1) and NAD(P)H Quinone Dehydrogenase 1 (NQO1), suggesting a beneficial effect at the level of mitochondria and oxidative stress." | 1.48 | Neuroprotective Effects of Creatine in the CMVMJD135 Mouse Model of Spinocerebellar Ataxia Type 3. ( Duarte-Silva, S; Maciel, P; Neves-Carvalho, A; Silva, JM; Silva-Fernandes, A; Soares-Cunha, C; Teixeira-Castro, A; Vieira, R, 2018) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (20.00) | 29.6817 |
| 2010's | 4 (80.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Xing, W | 1 |
| Liao, X | 1 |
| Guan, T | 1 |
| Xie, F | 1 |
| Shen, L | 2 |
| Liao, W | 2 |
| Wang, X | 1 |
| Duarte-Silva, S | 1 |
| Neves-Carvalho, A | 1 |
| Soares-Cunha, C | 1 |
| Silva, JM | 1 |
| Teixeira-Castro, A | 1 |
| Vieira, R | 1 |
| Silva-Fernandes, A | 1 |
| Maciel, P | 1 |
| Huang, SR | 1 |
| Wu, YT | 1 |
| Jao, CW | 1 |
| Soong, BW | 1 |
| Lirng, JF | 1 |
| Wu, HM | 1 |
| Wang, PS | 1 |
| Lei, L | 1 |
| Liao, Y | 1 |
| Zhou, J | 1 |
| Yuan, Y | 1 |
| Wang, J | 1 |
| Jiang, H | 1 |
| Tang, B | 1 |
| D'Abreu, A | 1 |
| França, M | 1 |
| Appenzeller, S | 1 |
| Lopes-Cendes, I | 1 |
| Cendes, F | 1 |
5 other studies available for creatine and Machado-Joseph Disease
| Article | Year |
|---|---|
[Value of 1H-MRS on SCA3/MJD diagnosis and clinical course].
Topics: Aspartic Acid; Brain Stem; Case-Control Studies; Cerebellar Nuclei; Cerebellum; Choline; Creatine; H | 2017 |
Neuroprotective Effects of Creatine in the CMVMJD135 Mouse Model of Spinocerebellar Ataxia Type 3.
Topics: Animals; Ataxin-3; Brain; Calbindins; Creatine; Diet; Disease Models, Animal; Female; Follow-Up Stud | 2018 |
CAG repeat length does not associate with the rate of cerebellar degeneration in spinocerebellar ataxia type 3.
Topics: Adult; Aged; Aspartic Acid; Cerebellum; Creatine; Cross-Sectional Studies; Female; Humans; Machado-J | 2017 |
Magnetic resonance spectroscopy of the cerebellum in patients with spinocerebellar ataxia type 3/Machado-Joseph disease.
Topics: Adult; Aspartic Acid; Case-Control Studies; Cerebellum; Choline; Creatine; Female; Humans; Machado-J | 2011 |
Axonal dysfunction in the deep white matter in Machado-Joseph disease.
Topics: Adult; Aged; Aspartic Acid; Case-Control Studies; Choline; Creatine; Female; Humans; Machado-Joseph | 2009 |