creatine and Innate Inflammatory Response studies

Research Excerpts

Excerpt	Relevance	Reference
"To evaluate the effects of canrenone compared to placebo on blood pressure control, some non-conventional biomarkers in cardiovascular stratification, and on metalloproteinases in patients affected by metabolic syndrome."	9.20	The effects of canrenone on inflammatory markers in patients with metabolic syndrome. ( Bianchi, L; D'Angelo, A; Derosa, G; Maffioli, P; Romano, D, 2015)
"The aim of this study was to evaluate the variation of homocysteine (Hcy) levels in patients with rheumatoid arthritis (RA) and to analyze the relationship to inflammatory parameters, cardiovascular risk, and methotrexate (MTX)."	8.31	Variation of homocysteine levels in rheumatoid arthritis patients: relationship to inflammation, cardiovascular risk factors, and methotrexate. ( Abdelmoula, L; Ben Ahmed, H; Ben Tekaya, A; Bouden, S; Bouzid, K; Mahmoud, I; Rouached, L; Saidane, O; Tekaya, R, 2023)
"Creatine supplementation prevented high-fat diet-induced non-alcoholic fatty liver disease progression, demonstrated by attenuated liver fat accumulation and liver damage."	8.12	Creatine supplementation protects against diet-induced non-alcoholic fatty liver but exacerbates alcoholic fatty liver. ( Cecchini, AL; Cella, PS; da Silva Brito, WA; da Silva, RP; Deminice, R; Duarte, JAR; Guirro, PB; Marinello, PC; Padilha, CS; Testa, MTJ, 2022)
"This opinion paper presents a brief review on the potential use of Creatine (Cr) to improve the inflammatory profile in individuals with Cerebral Palsy (CP)."	8.12	Creatine supplementation to improve the peripheral and central inflammatory profile in cerebral palsy. ( Gouveia, HJCB; Lacerda, DC; Manhães-de-Castro, R; Toscano, AE, 2022)
"Eighty MODS rats with third-degree burns were divided randomly into 4 groups: insulin, ethyl pyruvate (EP), insulin combined with EP, and control."	7.83	Effects of insulin combined with ethyl pyruvate on inflammatory response and oxidative stress in multiple-organ dysfunction syndrome rats with severe burns. ( Chen, R; Wang, S; Wang, Z; Zhang, X; Zhu, Z, 2016)
"Creatine (Cr) is a dietary supplement that presents beneficial effects in experimental models of heart and brain ischemia and reperfusion (I/R) injury."	7.83	Creatine supplementation attenuates pulmonary and systemic effects of lung ischemia and reperfusion injury. ( Albertini, R; Almeida, FM; Carvalho, PT; Castro-Faria-Neto, HC; Damaceno-Rodrigues, NR; Dolhnikoff, M; Lopes, FD; Martins, MA; Oliveira-Junior, MC; Pazetti, R; Petroni, RC; Soriano, FG; Soto, SF; Souza, RA; Vieira, RP, 2016)
"These results demonstrate that pre-treatment with paricalcitol has a renoprotective effect in ischemic AKI, possibly by suppressing TLR4-NF-κB mediated inflammation."	7.80	Renoprotective effect of paricalcitol via a modulation of the TLR4-NF-κB pathway in ischemia/reperfusion-induced acute kidney injury. ( Cho, E; Cho, WY; Jo, SK; Kim, HK; Kim, MG; Kim, SC; Ko, YS; Lee, HY; Lee, JW, 2014)
"Ibudilast-treated participants had lower Cho in superior frontal white matter and nominally lower MI in pregenual anterior cingulate cortex."	7.11	Effects of ibudilast on central and peripheral markers of inflammation in alcohol use disorder: A randomized clinical trial. ( Alger, J; Burnette, E; Evans, CJ; Grodin, EN; Irwin, MR; London, ED; Meredith, LR; Miotto, K; Nieto, SJ; O'Neill, J; Ray, LA, 2022)
"Creatine was provided in drinking water for a total of 21 days."	5.56	Creatine supplementation in Walker-256 tumor-bearing rats prevents skeletal muscle atrophy by attenuating systemic inflammation and protein degradation signaling. ( Borges, FH; Cecchini, R; Cella, PS; Chimin, P; Deminice, R; Duarte, JA; Guarnier, FA; Guirro, PB; Marinello, PC; Ribeiro, DF; Testa, MTJ, 2020)
"Fondaparinux is a synthetic pentasaccharide that selectively inhibits factor Xa (FXa) in the coagulation cascade."	5.33	The synthetic pentasaccharide fondaparinux reduces coagulation, inflammation and neutrophil accumulation in kidney ischemia-reperfusion injury. ( Frank, RD; Holscher, T; Mackman, N; Pawlinski, R; Sato, Y; Schabbauer, G; Tencati, M, 2005)
"The study purpose was to evaluate the effectiveness of creatine monohydrate supplementation (20 grams/day for 1 week and then 5 grams/day for 11 weeks) on inflammation (C-reactive protein, interleukin-1β, interleukin-6, s100 A8/A9, and tumor necrosis factor-α) and cartilage degradation (serum cartilage oligomeric matrix protein) in patients with knee osteoarthritis."	5.27	No effect of creatine monohydrate supplementation on inflammatory and cartilage degradation biomarkers in individuals with knee osteoarthritis. ( Cornish, SM; Peeler, JD, 2018)
"A diet rich in B-group vitamins is essential for optimal body and brain function, and insufficient amounts of such vitamins have been associated with higher levels of neural inflammation and oxidative stress, as marked by increased blood plasma homocysteine."	5.27	The Effect of a High-Dose Vitamin B Multivitamin Supplement on the Relationship between Brain Metabolism and Blood Biomarkers of Oxidative Stress: A Randomized Control Trial. ( Downey, LA; Ford, TC; McPhee, G; Oliver, C; Simpson, T; Stough, C, 2018)
"To evaluate the effects of canrenone compared to placebo on blood pressure control, some non-conventional biomarkers in cardiovascular stratification, and on metalloproteinases in patients affected by metabolic syndrome."	5.20	The effects of canrenone on inflammatory markers in patients with metabolic syndrome. ( Bianchi, L; D'Angelo, A; Derosa, G; Maffioli, P; Romano, D, 2015)
"The purpose of this study was to ascertain whether an oral, non-prescription, nutritional supplement compound composed of a proprietary alkali-buffered creatine monohydrate and cetylated fatty acids mixture (Kre-Celazine(®)) was efficacious in reducing or eliminating refractory pain and inflammation, without untoward effects, in Juvenile Rheumatoid Arthritis (JRA), which is also called Juvenile Idiopathic Arthritis (JIA)."	5.19	Kre-Celazine(®) as a viable treatment for juvenile rheumatoid arthritis/juvenile idiopathic arthritis - a pilot study. ( Golini, J; Jones, WL, 2014)
"The goal of this study was to evaluate the effects of creatine (Cr) supplementation on oxidative stress and inflammation markers after acute repeated-sprint exercise in humans."	5.17	Effects of creatine supplementation on oxidative stress and inflammatory markers after repeated-sprint exercise in humans. ( de Freitas, EC; Deminice, R; Franco, GS; Jordao, AA; Rosa, FT, 2013)
" Guanidinosuccinate correlated positively with plasma urea and negatively with inflammation markers."	5.13	Guanidino compounds after creatine supplementation in renal failure patients and their relation to inflammatory status. ( De Deyn, PP; De Vriese, A; Delanghe, JR; Marescau, B; Schepers, E; Taes, YE; Vanholder, R, 2008)
"The model highlighted a relevant contribution of inflammation (glycosylation pattern and HDL) and muscle (creatinine and creatine) in the development of type 2 diabetes as independent factors of hyperglycemia."	4.31	NMR-based metabolomic profiling identifies inflammation and muscle-related metabolites as predictors of incident type 2 diabetes mellitus beyond glucose: The Di@bet.es study. ( Amigó, N; Guardiola, M; Masana, L; Ozcariz, E; Rehues, P; Ribalta, J; Rojo-Martínez, G; Valdés, S, 2023)
"The aim of this study was to evaluate the variation of homocysteine (Hcy) levels in patients with rheumatoid arthritis (RA) and to analyze the relationship to inflammatory parameters, cardiovascular risk, and methotrexate (MTX)."	4.31	Variation of homocysteine levels in rheumatoid arthritis patients: relationship to inflammation, cardiovascular risk factors, and methotrexate. ( Abdelmoula, L; Ben Ahmed, H; Ben Tekaya, A; Bouden, S; Bouzid, K; Mahmoud, I; Rouached, L; Saidane, O; Tekaya, R, 2023)
"This opinion paper presents a brief review on the potential use of Creatine (Cr) to improve the inflammatory profile in individuals with Cerebral Palsy (CP)."	4.12	Creatine supplementation to improve the peripheral and central inflammatory profile in cerebral palsy. ( Gouveia, HJCB; Lacerda, DC; Manhães-de-Castro, R; Toscano, AE, 2022)
"Creatine supplementation prevented high-fat diet-induced non-alcoholic fatty liver disease progression, demonstrated by attenuated liver fat accumulation and liver damage."	4.12	Creatine supplementation protects against diet-induced non-alcoholic fatty liver but exacerbates alcoholic fatty liver. ( Cecchini, AL; Cella, PS; da Silva Brito, WA; da Silva, RP; Deminice, R; Duarte, JAR; Guirro, PB; Marinello, PC; Padilha, CS; Testa, MTJ, 2022)
"Creatine (Cr) is a dietary supplement that presents beneficial effects in experimental models of heart and brain ischemia and reperfusion (I/R) injury."	3.83	Creatine supplementation attenuates pulmonary and systemic effects of lung ischemia and reperfusion injury. ( Albertini, R; Almeida, FM; Carvalho, PT; Castro-Faria-Neto, HC; Damaceno-Rodrigues, NR; Dolhnikoff, M; Lopes, FD; Martins, MA; Oliveira-Junior, MC; Pazetti, R; Petroni, RC; Soriano, FG; Soto, SF; Souza, RA; Vieira, RP, 2016)
"Eighty MODS rats with third-degree burns were divided randomly into 4 groups: insulin, ethyl pyruvate (EP), insulin combined with EP, and control."	3.83	Effects of insulin combined with ethyl pyruvate on inflammatory response and oxidative stress in multiple-organ dysfunction syndrome rats with severe burns. ( Chen, R; Wang, S; Wang, Z; Zhang, X; Zhu, Z, 2016)
" The aim of this study was to provide objective evidence of local soft tissue injury by measuring serum creatine phosphokinase (CPK), a biochemical marker, to quantify muscle damage and inflammation in patients treated by the two approaches."	3.83	Markers of muscle damage for comparing soft tissue injury following proximal femur nail and dynamic hip screw operations for intertrochanteric hip fractures. ( Dudkiewicz, I; Segal, O; Steinberg, E; Wagman, Y, 2016)
"These results demonstrate that pre-treatment with paricalcitol has a renoprotective effect in ischemic AKI, possibly by suppressing TLR4-NF-κB mediated inflammation."	3.80	Renoprotective effect of paricalcitol via a modulation of the TLR4-NF-κB pathway in ischemia/reperfusion-induced acute kidney injury. ( Cho, E; Cho, WY; Jo, SK; Kim, HK; Kim, MG; Kim, SC; Ko, YS; Lee, HY; Lee, JW, 2014)
"Ibudilast-treated participants had lower Cho in superior frontal white matter and nominally lower MI in pregenual anterior cingulate cortex."	3.11	Effects of ibudilast on central and peripheral markers of inflammation in alcohol use disorder: A randomized clinical trial. ( Alger, J; Burnette, E; Evans, CJ; Grodin, EN; Irwin, MR; London, ED; Meredith, LR; Miotto, K; Nieto, SJ; O'Neill, J; Ray, LA, 2022)
"For delayed-onset muscle soreness (DOMS), the measures were lower for the CrM group at 24 h post-exercise with a moderate effect size (SMD - 0."	2.82	The Paradoxical Effect of Creatine Monohydrate on Muscle Damage Markers: A Systematic Review and Meta-Analysis. ( Boullosa, D; Connor, J; Doma, K; Ramachandran, AK, 2022)
"Pathological hallmarks of Parkinson's disease are destruction of dopaminergic neurons in the basal ganglia, especially the substantia nigra, and the presence of Lewy bodies within nerve cells."	2.46	Parkinson's disease: mitochondrial molecular pathology, inflammation, statins, and therapeutic neuroprotective nutrition. ( Kones, R, 2010)
"The pathogenesis of Parkinson's disease (PD) remains obscure, but there is increasing evidence that impairment of mitochondrial function, oxidative damage, and inflammation are contributing factors."	2.42	Mitochondria, oxidative damage, and inflammation in Parkinson's disease. ( Beal, MF, 2003)
"Creatine was provided in drinking water for a total of 21 days."	1.56	Creatine supplementation in Walker-256 tumor-bearing rats prevents skeletal muscle atrophy by attenuating systemic inflammation and protein degradation signaling. ( Borges, FH; Cecchini, R; Cella, PS; Chimin, P; Deminice, R; Duarte, JA; Guarnier, FA; Guirro, PB; Marinello, PC; Ribeiro, DF; Testa, MTJ, 2020)
"Creatine is a non-essential amino acid that is directly involved in the cross-bridge cycle providing a phosphate group to ADP during the initiation of muscle contraction."	1.48	High-fat diet suppresses the positive effect of creatine supplementation on skeletal muscle function by reducing protein expression of IGF-PI3K-AKT-mTOR pathway. ( Caldeira, EJ; Conte, M; Dos Santos, VC; Ferretti, R; Matsumura, CY; Mosqueira, M; Moura, EG; Pertille, A, 2018)
"In healthy term newborns with chorioamnionitis, MRS ratios shortly after birth may provide evidence of occult neuroinflammation, which may be associated with worse performance on 1-year neurodevelopmental tests."	1.42	Proton magnetic resonance spectroscopy and outcome in term neonates with chorioamnionitis. ( Bentzley, JP; Brown, T; Hope, K; Jenkins, DD; Johnson, CB; Katikaneni, LD; Lambert, D; Morgan, PS; Mulvihill, DM; Ramakrishnan, V; Rollins, LG, 2015)
"Monofocal acute inflammatory demyelination (MAID), which is observable by CT and MRI as a well-enhanced mass lesion with prominent perifocal edema, is very similar to malignant gliomas radiologically, making differential diagnosis of the two pathologies difficult."	1.37	Metabolic assessment of monofocal acute inflammatory demyelination using MR spectroscopy and (11)C-methionine-, (11)C-choline-, and (18)F-fluorodeoxyglucose-PET. ( Aki, T; Asano, Y; Ito, T; Iwama, T; Miwa, K; Shinoda, J; Takenaka, S; Yokoyama, K, 2011)
"Fondaparinux is a synthetic pentasaccharide that selectively inhibits factor Xa (FXa) in the coagulation cascade."	1.33	The synthetic pentasaccharide fondaparinux reduces coagulation, inflammation and neutrophil accumulation in kidney ischemia-reperfusion injury. ( Frank, RD; Holscher, T; Mackman, N; Pawlinski, R; Sato, Y; Schabbauer, G; Tencati, M, 2005)
"Ischemia-reperfusion injury is caused by the activation of inflammatory and cytoprotective genes, such as macrophage chemoattractant protein-1 and heme oxygenase-1, respectively."	1.33	Influence of bradykinin B1 and B2 receptors in the immune response triggered by renal ischemia-reperfusion injury. ( Câmara, NO; Cenedeze, MA; Pacheco-Silva, A; Pesquero, JB; Wang, PH, 2006)
"Creatine is an aminoacid which has been found to posses anti-inflammatory activity."	1.26	Studies on the anti-inflammatory activity of creatine. ( Khanna, NK; Madan, BR, 1978)

Research

Studies (61)

Authors

Clinical Trials (3)

Trial Overview

Trial Outcomes

McMaster Gross Motor Function (GMFM 88)

Timeframe	Studies, this research(%)	All Research%
pre-1990	1 (1.64)	18.7374
1990's	1 (1.64)	18.2507
2000's	11 (18.03)	29.6817
2010's	32 (52.46)	24.3611
2020's	16 (26.23)	2.80

Authors	Studies
Tekaya, R	1
Rouached, L	1
Ben Ahmed, H	1
Ben Tekaya, A	1
Bouden, S	1
Saidane, O	1
Bouzid, K	1
Mahmoud, I	1
Abdelmoula, L	1
Lorè, NI	1
De Lorenzo, R	1
Rancoita, PMV	1
Cugnata, F	1
Agresti, A	1
Benedetti, F	1
Bianchi, ME	1
Bonini, C	1
Capobianco, A	1
Conte, C	1
Corti, A	1
Furlan, R	1
Mantegani, P	1
Maugeri, N	1
Sciorati, C	1
Saliu, F	1
Silvestri, L	1
Tresoldi, C	1
Ciceri, F	1
Rovere-Querini, P	1
Di Serio, C	1
Cirillo, DM	1
Manfredi, AA	1
Maqdasy, S	1
Lecoutre, S	1
Renzi, G	1
Frendo-Cumbo, S	1
Rizo-Roca, D	1
Moritz, T	1
Juvany, M	1
Hodek, O	1
Gao, H	1
Couchet, M	1
Witting, M	1
Kerr, A	1
Bergo, MO	1
Choudhury, RP	1
Aouadi, M	1
Zierath, JR	1
Krook, A	1
Mejhert, N	1
Rydén, M	1
Doma, K	1
Ramachandran, AK	1
Boullosa, D	1
Connor, J	1
Donahue, EK	1
Bui, V	1
Foreman, RP	1
Duran, JJ	1
Venkadesh, S	1
Choupan, J	1
Van Horn, JD	1
Alger, JR	1
Jakowec, MW	1
Petzinger, GM	1
O'Neill, J	2
Grodin, EN	1
Nieto, SJ	1
Meredith, LR	1
Burnette, E	1
Alger, J	1
London, ED	1
Miotto, K	1
Evans, CJ	1
Irwin, MR	1
Ray, LA	1
Marinello, PC	2
Cella, PS	2
Testa, MTJ	2
Guirro, PB	2
da Silva Brito, WA	1
Padilha, CS	1
Cecchini, AL	1
da Silva, RP	1
Duarte, JAR	1
Deminice, R	3
Gouveia, HJCB	2
Manhães-de-Castro, R	2
Lacerda, DC	2
Toscano, AE	2
Vints, WAJ	1
Kušleikienė, S	1
Sheoran, S	1
Valatkevičienė, K	1
Gleiznienė, R	1
Himmelreich, U	1
Pääsuke, M	1
Česnaitienė, VJ	1
Levin, O	1
Verbunt, J	1
Masiulis, N	1
Ozcariz, E	1
Guardiola, M	1
Amigó, N	1
Rojo-Martínez, G	1
Valdés, S	1
Rehues, P	1
Masana, L	1
Ribalta, J	1
Marini, ACB	1
Motobu, RD	1
Freitas, ATV	1
Mota, JF	2
Wall, BT	1
Pichard, C	1
Laviano, A	1
Pimentel, GD	2
Boban, J	1
Thurnher, MM	1
Brkic, S	1
Lendak, D	1
Bugarski Ignjatovic, V	1
Todorovic, A	1
Kozic, D	1
Greif, DN	1
Emerson, CP	1
Allegra, P	1
Arizpe, A	1
Mansour, KL	1
Cade, WH	1
Baraga, MG	1
Oliveira, CLP	1
Antunes, BMM	1
Gomes, AC	1
Lira, FS	1
Boulé, NG	1
Gala, K	1
Desai, V	1
Liu, N	1
Omer, EM	1
McClave, SA	1
Graham, AS	1
Holmes, MJ	1
Little, F	1
Dobbels, E	1
Cotton, MF	1
Laughton, B	1
van der Kouwe, A	1
Meintjes, EM	1
Robertson, FC	1
Kustán, P	1
Szirmay, B	1
Kőszegi, T	1
Ludány, A	1
Kovács, GL	1
Miseta, A	1
Mühl, D	1
Németh, B	1
Kiss, I	1
Németh, Á	1
Szabados, S	1
Ajtay, Z	1
Bell, KE	1
Snijders, T	1
Zulyniak, MA	1
Kumbhare, D	1
Parise, G	1
Chabowski, A	1
Phillips, SM	1
El-Bassossy, HM	1
Eid, BG	1
Cornish, SM	1
Peeler, JD	1
Ferretti, R	1
Moura, EG	1
Dos Santos, VC	1
Caldeira, EJ	1
Conte, M	1
Matsumura, CY	1
Pertille, A	1
Mosqueira, M	1
Zhou, Y	1
Qi, C	1
Li, S	1
Shao, X	1
Mou, S	1
Ni, Z	1
Ford, TC	1
Downey, LA	1
Simpson, T	1
McPhee, G	1
Oliver, C	1
Stough, C	1
Lemos, NE	1
Dieter, C	1
Carlessi, R	1
Rheinheimer, J	1
Brondani, LA	1
Leitão, CB	1
Bauer, AC	1
Crispim, D	1
Borges, FH	1
Ribeiro, DF	1
Chimin, P	1
Duarte, JA	1
Cecchini, R	1
Guarnier, FA	1
Simpson, AJ	1
Horne, S	1
Sharp, P	1
Sharps, R	1
Kippelen, P	1
Zhang, C	1
Yu, S	1
Zheng, B	1
Liu, D	1
Wan, F	1
Ma, Y	1
Wang, J	1
Gao, Z	1
Shan, Z	1
Silva, LA	1
Tromm, CB	1
Da Rosa, G	1
Bom, K	1
Luciano, TF	1
Tuon, T	1
De Souza, CT	1
Pinho, RA	1
Rosa, FT	1
Franco, GS	1
Jordao, AA	1
de Freitas, EC	1
da Silva, VR	1
Rios-Avila, L	1
Lamers, Y	1
Ralat, MA	1
Midttun, Ø	1
Quinlivan, EP	1
Garrett, TJ	1
Coats, B	1
Shankar, MN	1
Percival, SS	1
Chi, YY	1
Muller, KE	1
Ueland, PM	1
Stacpoole, PW	1
Gregory, JF	1
Lee, JW	1
Kim, SC	1
Ko, YS	1
Lee, HY	1
Cho, E	1
Kim, MG	1
Jo, SK	1
Cho, WY	1
Kim, HK	1
Li, P	1
Bledsoe, G	1
Yang, ZR	1
Fan, H	1
Chao, L	1
Chao, J	1
Golini, J	1
Jones, WL	1
Derosa, G	1
Romano, D	1
Bianchi, L	1
D'Angelo, A	1
Maffioli, P	1
Chiappelli, J	1
Hong, LE	1
Wijtenburg, SA	1
Du, X	1
Gaston, F	1
Kochunov, P	1
Rowland, LM	1
Almeida, FM	1
Oliveira-Junior, MC	1
Souza, RA	1
Petroni, RC	1
Soto, SF	1
Soriano, FG	1
Carvalho, PT	1
Albertini, R	1
Damaceno-Rodrigues, NR	1
Lopes, FD	1
Castro-Faria-Neto, HC	1
Martins, MA	1
Dolhnikoff, M	1
Pazetti, R	1
Vieira, RP	1
Li, Q	1
Leung, YO	1
Zhou, I	1
Ho, LC	1
Kong, W	1
Basil, P	1
Wei, R	1
Lam, S	1
Zhang, X	2
Law, AC	1
Chua, SE	1
Sham, PC	1
Wu, EX	1
McAlonan, GM	1
Johnson, CB	1
Jenkins, DD	1
Bentzley, JP	1
Lambert, D	1
Hope, K	1
Rollins, LG	1
Morgan, PS	1
Brown, T	1
Ramakrishnan, V	1
Mulvihill, DM	1
Katikaneni, LD	1
Tipton, KD	1
Riesberg, LA	1
Weed, SA	1
McDonald, TL	1
Eckerson, JM	1
Drescher, KM	1
Bilgic, F	1
Akinci Sozer, O	1
Ozcan, O	1
Gurpinar, AB	1
Yilmaz, H	1
Ay, Y	1
Wang, Z	1
Chen, R	1
Zhu, Z	1
Wang, S	1
Wagman, Y	1
Segal, O	1
Dudkiewicz, I	1
Steinberg, E	1
Hitchon, CA	1
El-Gabalawy, HS	1
Bezabeh, T	1
Kones, R	1
Takenaka, S	1
Shinoda, J	1
Asano, Y	1
Aki, T	1
Miwa, K	1
Ito, T	1
Yokoyama, K	1
Iwama, T	1
Morena, M	1
Patrier, L	1
Jaussent, I	1
Bargnoux, AS	1
Dupuy, AM	1
Badiou, S	1
Leray-Moragues, H	1
Klouche, K	1
Canaud, B	1
Cristol, JP	1
Cherney, DZ	1
Scholey, JW	1
Daneman, D	1
Dunger, DB	1
Dalton, RN	1
Moineddin, R	1
Mahmud, FH	1
Dekker, R	1
Elia, Y	1
Sochett, E	1
Reich, HN	1
Mellergård, J	1
Tisell, A	1
Dahlqvist Leinhard, O	1
Blystad, I	1
Landtblom, AM	1
Blennow, K	1
Olsson, B	1
Dahle, C	1
Ernerudh, J	1
Lundberg, P	1
Vrethem, M	1
Jeschke, MG	1
Barrow, RE	1
Suzuki, F	1
Rai, J	1
Benjamin, D	1
Herndon, DN	1
Nomura, A	1
Zhang, M	1
Sakamoto, T	1
Ishii, Y	1
Morishima, Y	1
Mochizuki, M	1
Kimura, T	1
Uchida, Y	1
Sekizawa, K	1
Beal, MF	2
Klivenyi, P	1
Gardian, G	1
Calingasan, NY	1
Yang, L	1
Frank, RD	1
Schabbauer, G	1
Holscher, T	1
Sato, Y	1
Tencati, M	1
Pawlinski, R	1
Mackman, N	1
Melek, E	1
Ozyer, U	1
Erol, I	1
Alehan, F	1
Muhteşem Ağildere, A	1
Wang, PH	1
Cenedeze, MA	1
Pesquero, JB	1
Pacheco-Silva, A	1
Câmara, NO	1
Roc, AC	1
Ances, BM	1
Chawla, S	1
Korczykowski, M	1
Wolf, RL	1
Kolson, DL	1
Detre, JA	1
Poptani, H	1
Bassit, RA	1
Curi, R	1
Costa Rosa, LF	1
Taes, YE	1
Marescau, B	1
De Vriese, A	1
De Deyn, PP	1
Schepers, E	1
Vanholder, R	1
Delanghe, JR	1
Stockhammer, G	1
Felber, SR	1
Zelger, B	1
Sepp, N	1
Birbamer, GG	1
Fritsch, PO	1
Aichner, FT	1
Khanna, NK	1
Madan, BR	1

Trial	Phase	Enrollment	Study Type	Start Date	Status
Evaluation of Some Emerging Biomarkers of Cardiovascular Risk Stratification in Hypertensive Patients: a 5-years Follow-up[NCT02064218]		0 participants	Observational	2007-11-30	Recruiting
Randomised, Double Blind, Placebo Controlled Trial of Angiotensin Converting Enzyme Inhibitors and Statins in the Prevention of Long Term Complications in Young People With Type 1 Diabetes[NCT01581476]	Phase 3	443 participants (Actual)	Interventional	2009-01-31	Completed
Phase 3 Trial of Coenzyme Q10 in Mitochondrial Disease[NCT00432744]	Phase 3	24 participants (Actual)	Interventional	2007-01-31	Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

The McMaster Gross Motor Function is a validated scale ranging from 0 to 100 (the higher the better). Since there was the possibility of a subject becoming totally disabled our FDA peer reviewed design called for its use as follows: If the subject completed both periods, the score was calculated as the difference in scores between the end of Period 2 (at 12 months) minus that at the end of Period 1 (6 months). If a subject became totally disabled, this difference was considered as plus infinity if it occurred in period 1 (Penalizes period 1), and minus infinity if it occurred in Period 2 (Penalizes period 2). The two treatments were compared via the Wilcoxon test, and the effect size was estimated using Kendall's Tau-B. This is interpreted in a similar manner to correlation with positive values favoring COQenzyme10 and negative values favoring placebo. One of the links in this report is to the the GMFM scale and how it is scored. A link to the instrument is included. (NCT00432744)
Timeframe: Taken at 6 and 12 Months

Non-parametric Hotelling T-square Bivariate Analysis of GMGF 88 and OPeds QOL.

Intervention	units on a scale (Median)
Placebo First	-0.002
CoenzymeQ10 Frist	-0.12

This is a multivariate analysis of the first two outcomes: Period 2 minus Period 1 GMFM88 and Peds Quality of Life, analyzed as follows: First, to be in the analysis, subjects must contribute at least one of these endpoints. Second, if the subject became totally disabled during period 1, the difference was defined as + infinity, (highest possible evidence favoring period 2), and if the subject became totally disabled in period 2, the subject was scored as - infinity (highest possible evidence favoring period 1). Period 2 minus period 1 differences were ranked form low to high with missing values scores at the mid-rank. The Hotelling T-square was computed on these ranks and the P-value was obtained from 100,000 rerandomizations as the fraction of rerandomizations with T-sq at least as large as that observed. (NCT00432744)
Timeframe: end of 12 month minus end of 6 month difference.

Pediatric Quality of Life Scale

Intervention	participants (Number)
Placebo First	7
CoenzymeQ10 Frist	8

"The Pediatric Quality of Life Scale is a validated scale ranging from 0 to 100 (the higher the better). Since there was the possibility of a subject becoming totally disabled our FDA peer reviewed design called for its use as follows: If the subject completed both periods, the score was calculated as the difference in scores between the end of Period 2 (at 12 months) minus that at the end of Period 1 (6 months). If a subject became totally disabled, this difference was considered as plus infinity if it occurred in period 1 (Penalizes period 1), and minus infinity if it occurred in Period 2 (Penalizes period 2). The two treatments were compared via the Wilcoxon test, and the effect size was estimated using Kendall's Tau-B. This is interpreted in a similar manner to correlation with positive values favoring COQenzyme10 and negative values favoring placebo. Goggle pedsQL and Mapi to browse the copyrighted manual. A link to the instrument is included." (NCT00432744)
Timeframe: At 6 and 12 Months

Article	Year
The Paradoxical Effect of Creatine Monohydrate on Muscle Damage Markers: A Systematic Review and Meta-Analysis. Sports medicine (Auckland, N.Z.), 2022, Volume: 52, Issue:7 Topics: Adolescent; Adult; Biomarkers; Creatine; Dietary Supplements; Female; Humans; Inflammation; Muscle,	2022
Supplement Use in Patients Undergoing Anterior Cruciate Ligament Reconstruction: A Systematic Review. Arthroscopy : the journal of arthroscopic & related surgery : official publication of the Arthroscopy Association of North America and the International Arthroscopy Association, 2020, Volume: 36, Issue:9 Topics: Anterior Cruciate Ligament Injuries; Anterior Cruciate Ligament Reconstruction; Ascorbic Acid; Creat	2020
How to Increase Muscle Mass in Critically Ill Patients: Lessons Learned from Athletes and Bodybuilders. Current nutrition reports, 2020, Volume: 9, Issue:4 Topics: Athletes; Creatine; Critical Illness; Dietary Supplements; Eating; Exercise; Hospitalization; Humans	2020
Nutritional Support for Exercise-Induced Injuries. Sports medicine (Auckland, N.Z.), 2015, Volume: 45 Suppl 1 Topics: Amino Acids; Antioxidants; Athletic Injuries; Creatine; Dietary Proteins; Dietary Supplements; Energ	2015
Beyond muscles: The untapped potential of creatine. International immunopharmacology, 2016, Volume: 37 Topics: Animals; Anti-Inflammatory Agents; Athletes; Central Nervous System Diseases; Creatine; Dietary Supp	2016
Parkinson's disease: mitochondrial molecular pathology, inflammation, statins, and therapeutic neuroprotective nutrition. Nutrition in clinical practice : official publication of the American Society for Parenteral and Enteral Nutrition, 2010, Volume: 25, Issue:4 Topics: Anti-Inflammatory Agents; Cholesterol; Creatine; Diet Therapy; Fatty Acids, Omega-3; Humans; Hydroxy	2010
Mitochondria, oxidative damage, and inflammation in Parkinson's disease. Annals of the New York Academy of Sciences, 2003, Volume: 991 Topics: Animals; Anti-Inflammatory Agents; Coenzymes; Creatine; Disease Models, Animal; Free Radicals; Human	2003

Article	Year
Effects of ibudilast on central and peripheral markers of inflammation in alcohol use disorder: A randomized clinical trial. Addiction biology, 2022, Volume: 27, Issue:4 Topics: Alcohol Drinking; Alcoholism; Animals; Aspartic Acid; C-Reactive Protein; Choline; Creatine; Humans;	2022
Creatine supplementation does not promote additional effects on inflammation and insulin resistance in older adults: A pilot randomized, double-blind, placebo-controlled trial. Clinical nutrition ESPEN, 2020, Volume: 38 Topics: Aged; Body Composition; Creatine; Dietary Supplements; Humans; Inflammation; Insulin Resistance; Mus	2020
A multi-ingredient nutritional supplement enhances exercise training-related reductions in markers of systemic inflammation in healthy older men. Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme, 2018, Volume: 43, Issue:3 Topics: Aged; Beverages; Biomarkers; Calcium; Creatine; Dietary Supplements; Docosahexaenoic Acids; Eicosape	2018
No effect of creatine monohydrate supplementation on inflammatory and cartilage degradation biomarkers in individuals with knee osteoarthritis. Nutrition research (New York, N.Y.), 2018, Volume: 51 Topics: Aged; Biomarkers; C-Reactive Protein; Calgranulin A; Cartilage; Cartilage Oligomeric Matrix Protein;	2018
Diabetic Nephropathy Can Be Treated with Calcium Dobesilate by Alleviating the Chronic Inflammatory State and Improving Endothelial Cell Function. Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, 2018, Volume: 51, Issue:3 Topics: Aged; Albuminuria; Anti-Inflammatory Agents; Calcium Dobesilate; Chronic Disease; Creatine; Cross-Se	2018
The Effect of a High-Dose Vitamin B Multivitamin Supplement on the Relationship between Brain Metabolism and Blood Biomarkers of Oxidative Stress: A Randomized Control Trial. Nutrients, 2018, Dec-01, Volume: 10, Issue:12 Topics: Adult; Aged; Antioxidants; Aspartic Acid; Biomarkers; Brain; Cognition; Cognition Disorders; Creatin	2018
Effect of Creatine Supplementation on the Airways of Youth Elite Soccer Players. Medicine and science in sports and exercise, 2019, Volume: 51, Issue:8 Topics: Adolescent; Biomarkers; Breath Tests; Creatine; Dietary Supplements; Double-Blind Method; Forced Exp	2019
Effects of creatine supplementation on oxidative stress and inflammatory markers after repeated-sprint exercise in humans. Nutrition (Burbank, Los Angeles County, Calif.), 2013, Volume: 29, Issue:9 Topics: Adolescent; Antioxidants; Biomarkers; C-Reactive Protein; Creatine; Dietary Supplements; Double-Blin	2013
Kre-Celazine(®) as a viable treatment for juvenile rheumatoid arthritis/juvenile idiopathic arthritis - a pilot study. Journal of medicinal food, 2014, Volume: 17, Issue:9 Topics: Adolescent; Analgesics; Anti-Inflammatory Agents; Arthritis, Juvenile; Blood Sedimentation; C-Reacti	2014
The effects of canrenone on inflammatory markers in patients with metabolic syndrome. Annals of medicine, 2015, Volume: 47, Issue:1 Topics: Aged; Aldosterone; Biomarkers; Blood Glucose; Blood Pressure; Body Mass Index; Body Weight; Canrenon	2015
Urinary markers of renal inflammation in adolescents with Type 1 diabetes mellitus and normoalbuminuria. Diabetic medicine : a journal of the British Diabetic Association, 2012, Volume: 29, Issue:10 Topics: Adolescent; Albuminuria; Biomarkers; Chemokines; Child; Creatine; Cytokines; Diabetes Mellitus, Type	2012
Association between change in normal appearing white matter metabolites and intrathecal inflammation in natalizumab-treated multiple sclerosis. PloS one, 2012, Volume: 7, Issue:9 Topics: Adult; Antibodies, Monoclonal, Humanized; Choline; Creatine; Female; Humans; Inflammation; Interleuk	2012
Creatine supplementation reduces plasma levels of pro-inflammatory cytokines and PGE2 after a half-ironman competition. Amino acids, 2008, Volume: 35, Issue:2 Topics: Adult; Creatine; Cytokines; Dietary Supplements; Dinoprostone; Humans; Inflammation; Middle Aged; Ph	2008
Guanidino compounds after creatine supplementation in renal failure patients and their relation to inflammatory status. Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, 2008, Volume: 23, Issue:4 Topics: Administration, Oral; Aged; Arginine; Biomarkers; C-Reactive Protein; Creatine; Cross-Over Studies;	2008

Article	Year
Variation of homocysteine levels in rheumatoid arthritis patients: relationship to inflammation, cardiovascular risk factors, and methotrexate. Zeitschrift fur Rheumatologie, 2023, Volume: 82, Issue:Suppl 1 Topics: Adult; Arthritis, Rheumatoid; Cardiovascular Diseases; Creatine; Cross-Sectional Studies; Folic Acid	2023
CXCL10 levels at hospital admission predict COVID-19 outcome: hierarchical assessment of 53 putative inflammatory biomarkers in an observational study. Molecular medicine (Cambridge, Mass.), 2021, 10-18, Volume: 27, Issue:1 Topics: Biomarkers; C-Reactive Protein; Chemokine CXCL10; Comorbidity; Coronary Artery Disease; COVID-19; Cr	2021
Impaired phosphocreatine metabolism in white adipocytes promotes inflammation. Nature metabolism, 2022, Volume: 4, Issue:2 Topics: Adipocytes, White; Animals; Creatine; Humans; Inflammation; Mice; Obesity; Phosphocreatine	2022
Magnetic resonance spectroscopy shows associations between neurometabolite levels and perivascular space volume in Parkinson's disease: a pilot and feasibility study. Neuroreport, 2022, 05-04, Volume: 33, Issue:7 Topics: Aspartic Acid; Brain; Creatine; Feasibility Studies; Humans; Inflammation; Magnetic Resonance Imagin	2022
Creatine supplementation protects against diet-induced non-alcoholic fatty liver but exacerbates alcoholic fatty liver. Life sciences, 2022, Dec-01, Volume: 310 Topics: Animals; Creatine; Diet, High-Fat; Dietary Supplements; Ethanol; Fatty Liver, Alcoholic; Inflammatio	2022
Creatine supplementation to improve the peripheral and central inflammatory profile in cerebral palsy. Clinical nutrition ESPEN, 2022, Volume: 52 Topics: Cerebral Palsy; Child; Creatine; Dietary Supplements; Disabled Persons; Humans; Inflammation; Motor	2022
Creatine supplementation to improve the peripheral and central inflammatory profile in cerebral palsy. Clinical nutrition ESPEN, 2022, Volume: 52 Topics: Cerebral Palsy; Child; Creatine; Dietary Supplements; Disabled Persons; Humans; Inflammation; Motor	2022
Creatine supplementation to improve the peripheral and central inflammatory profile in cerebral palsy. Clinical nutrition ESPEN, 2022, Volume: 52 Topics: Cerebral Palsy; Child; Creatine; Dietary Supplements; Disabled Persons; Humans; Inflammation; Motor	2022
Creatine supplementation to improve the peripheral and central inflammatory profile in cerebral palsy. Clinical nutrition ESPEN, 2022, Volume: 52 Topics: Cerebral Palsy; Child; Creatine; Dietary Supplements; Disabled Persons; Humans; Inflammation; Motor	2022
Body fat and components of sarcopenia relate to inflammation, brain volume, and neurometabolism in older adults. Neurobiology of aging, 2023, Volume: 127 Topics: Adipose Tissue; Aged; Aged, 80 and over; Biomarkers; Brain; Creatine; Encephalitis; Hand Strength; H	2023
NMR-based metabolomic profiling identifies inflammation and muscle-related metabolites as predictors of incident type 2 diabetes mellitus beyond glucose: The Di@bet.es study. Diabetes research and clinical practice, 2023, Volume: 202 Topics: Creatine; Creatinine; Diabetes Mellitus, Type 2; Glucose; Humans; Inflammation; Magnetic Resonance S	2023
Short-Term Creatine Supplementation May Alleviate the Malnutrition-Inflammation Score and Lean Body Mass Loss in Hemodialysis Patients: A Pilot Randomized Placebo-Controlled Trial. JPEN. Journal of parenteral and enteral nutrition, 2020, Volume: 44, Issue:5 Topics: Adolescent; Adult; Body Composition; Creatine; Dietary Supplements; Double-Blind Method; Female; Hum	2020
Neurometabolic Remodeling in Chronic Hiv Infection: a Five-Year Follow-up Multi-Voxel Mrs Study. Scientific reports, 2019, 12-24, Volume: 9, Issue:1 Topics: Adult; Algorithms; Anti-HIV Agents; Aspartic Acid; Brain; Brain Neoplasms; Cell Communication; Cell	2019
MRS suggests multi-regional inflammation and white matter axonal damage at 11 years following perinatal HIV infection. NeuroImage. Clinical, 2020, Volume: 28 Topics: Anti-Retroviral Agents; Aspartic Acid; Child; Creatine; Female; HIV Infections; Humans; Inflammation	2020
Monitoring urinary orosomucoid in patients undergoing cardiac surgery: A promising novel inflammatory marker. Clinical biochemistry, 2017, Volume: 50, Issue:18 Topics: Aged; Biomarkers; C-Reactive Protein; Cardiovascular Diseases; Creatine; Female; Follow-Up Studies;	2017
Cyclosporine A exhibits gender-specific nephrotoxicity in rats: Effect on renal tissue inflammation. Biochemical and biophysical research communications, 2018, 01-01, Volume: 495, Issue:1 Topics: Animals; Creatine; Cyclosporine; Female; Immunosuppressive Agents; Inflammation; Kidney; Kidney Dise	2018
High-fat diet suppresses the positive effect of creatine supplementation on skeletal muscle function by reducing protein expression of IGF-PI3K-AKT-mTOR pathway. PloS one, 2018, Volume: 13, Issue:10 Topics: Adenosine Diphosphate; Animals; Antioxidants; Creatine; Diet, High-Fat; Dietary Supplements; Inflamm	2018
Renal effects of exendin-4 in an animal model of brain death. Molecular biology reports, 2019, Volume: 46, Issue:2 Topics: Animals; Apoptosis; Brain Death; Creatine; Cytokines; Disease Models, Animal; Exenatide; Genes, bcl-	2019
Creatine supplementation in Walker-256 tumor-bearing rats prevents skeletal muscle atrophy by attenuating systemic inflammation and protein degradation signaling. European journal of nutrition, 2020, Volume: 59, Issue:2 Topics: Animals; Carcinoma 256, Walker; Creatine; Dietary Supplements; Disease Models, Animal; Inflammation;	2020
miR-30c-5p Reduces Renal Ischemia-Reperfusion Involving Macrophage. Medical science monitor : international medical journal of experimental and clinical research, 2019, Jun-11, Volume: 25 Topics: Acute Kidney Injury; Animals; Creatine; Humans; Inflammation; Kidney; Lipocalin-2; Macrophages; Male	2019
Creatine supplementation does not decrease oxidative stress and inflammation in skeletal muscle after eccentric exercise. Journal of sports sciences, 2013, Volume: 31, Issue:11 Topics: Animals; Antioxidants; Creatine; Creatine Kinase; Dietary Supplements; Inflammation; Male; Oxidative	2013
Metabolite profile analysis reveals functional effects of 28-day vitamin B-6 restriction on one-carbon metabolism and tryptophan catabolic pathways in healthy men and women. The Journal of nutrition, 2013, Volume: 143, Issue:11 Topics: Adult; Biomarkers; Creatine; Cystathionine; Female; Humans; Inflammation; Kynurenic Acid; Kynurenine	2013
Renoprotective effect of paricalcitol via a modulation of the TLR4-NF-κB pathway in ischemia/reperfusion-induced acute kidney injury. Biochemical and biophysical research communications, 2014, Feb-07, Volume: 444, Issue:2 Topics: Acute Kidney Injury; Animals; Blotting, Western; Cell Line; Chemokine CCL2; Chemokines; Creatine; Er	2014
Human kallistatin administration reduces organ injury and improves survival in a mouse model of polymicrobial sepsis. Immunology, 2014, Volume: 142, Issue:2 Topics: Animals; Apoptosis; Blood Urea Nitrogen; Caspase 3; Creatine; Disease Models, Animal; HMGB1 Protein;	2014
Alterations in frontal white matter neurochemistry and microstructure in schizophrenia: implications for neuroinflammation. Translational psychiatry, 2015, Apr-14, Volume: 5 Topics: Adult; Age Factors; Anisotropy; Aspartic Acid; Case-Control Studies; Choline; Creatine; Diffusion Te	2015
Creatine supplementation attenuates pulmonary and systemic effects of lung ischemia and reperfusion injury. The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation, 2016, Volume: 35, Issue:2 Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Antioxidants; Apoptosis; Blotting, Western; Creati	2016
Dietary supplementation with n-3 fatty acids from weaning limits brain biochemistry and behavioural changes elicited by prenatal exposure to maternal inflammation in the mouse model. Translational psychiatry, 2015, Sep-22, Volume: 5 Topics: Animals; Aspartic Acid; Behavior, Animal; Creatine; Diet, High-Fat; Dietary Supplements; Fatty Acids	2015
Proton magnetic resonance spectroscopy and outcome in term neonates with chorioamnionitis. Journal of perinatology : official journal of the California Perinatal Association, 2015, Volume: 35, Issue:12 Topics: Basal Ganglia; Brain; Choline; Chorioamnionitis; Creatine; Dipeptides; Female; Healthy Volunteers; H	2015
Evaluation of inflammation during fixed orthodontic treatment. Archives of oral biology, 2016, Volume: 71 Topics: Adolescent; Alanine Transaminase; Alkaline Phosphatase; Aspartate Aminotransferases; Biomarkers; C-R	2016
Effects of insulin combined with ethyl pyruvate on inflammatory response and oxidative stress in multiple-organ dysfunction syndrome rats with severe burns. The American journal of emergency medicine, 2016, Volume: 34, Issue:11 Topics: Alanine Transaminase; Animals; Antioxidants; Blood Glucose; Burns; Creatine; Creatine Kinase; Drug T	2016
Markers of muscle damage for comparing soft tissue injury following proximal femur nail and dynamic hip screw operations for intertrochanteric hip fractures. Injury, 2016, Volume: 47, Issue:12 Topics: Adult; Aged; Aged, 80 and over; Biomarkers; Bone Nails; Bone Screws; Creatine; Female; Fracture Fixa	2016
Characterization of synovial tissue from arthritis patients: a proton magnetic resonance spectroscopic investigation. Rheumatology international, 2009, Volume: 29, Issue:10 Topics: Adult; Aged; Aged, 80 and over; Arthritis, Rheumatoid; Case-Control Studies; Choline; Creatine; Fuco	2009
Metabolic assessment of monofocal acute inflammatory demyelination using MR spectroscopy and (11)C-methionine-, (11)C-choline-, and (18)F-fluorodeoxyglucose-PET. Brain tumor pathology, 2011, Volume: 28, Issue:3 Topics: Brain Neoplasms; Carbon Radioisotopes; Choline; Creatine; Demyelinating Diseases; Diagnosis, Differe	2011
Reduced glomerular filtration rate, inflammation and HDL cholesterol as main determinants of superoxide production in non-dialysis chronic kidney disease patients. Free radical research, 2011, Volume: 45, Issue:6 Topics: Adult; Aged; Aged, 80 and over; Biomarkers; Case-Control Studies; Cholesterol, HDL; Creatine; Female	2011
IGF-I/IGFBP-3 equilibrates ratios of pro- to anti-inflammatory cytokines, which are predictors for organ function in severely burned pediatric patients. Molecular medicine (Cambridge, Mass.), 2002, Volume: 8, Issue:5 Topics: Adolescent; Biomarkers; Burns; Child; Child, Preschool; Cholinesterases; Creatine; Cytokines; Female	2002
Anti-inflammatory activity of creatine supplementation in endothelial cells in vitro. British journal of pharmacology, 2003, Volume: 139, Issue:4 Topics: Adenosine Triphosphate; Anti-Inflammatory Agents; Cell Adhesion; Cells, Cultured; Creatine; Dietary	2003
Additive neuroprotective effects of creatine and a cyclooxygenase 2 inhibitor against dopamine depletion in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) mouse model of Parkinson's disease. Journal of molecular neuroscience : MN, 2003, Volume: 21, Issue:3 Topics: Animals; Creatine; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Disease	2003
The synthetic pentasaccharide fondaparinux reduces coagulation, inflammation and neutrophil accumulation in kidney ischemia-reperfusion injury. Journal of thrombosis and haemostasis : JTH, 2005, Volume: 3, Issue:3 Topics: Animals; Blood Coagulation; Cell Movement; Chemokine CXCL2; Creatine; Drug Evaluation, Preclinical;	2005
+H-proton-magnetic resonance spectroscopic findings in a patient with acute hemicerebellitis presenting without localized signs: a case report. European journal of paediatric neurology : EJPN : official journal of the European Paediatric Neurology Society, 2006, Volume: 10, Issue:4 Topics: Acute Disease; Adolescent; Aspartic Acid; Cerebellar Diseases; Choline; Cranial Fossa, Posterior; Cr	2006
Influence of bradykinin B1 and B2 receptors in the immune response triggered by renal ischemia-reperfusion injury. International immunopharmacology, 2006, Dec-20, Volume: 6, Issue:13-14 Topics: Animals; Chemokine CCL2; Creatine; Gene Expression; Heme Oxygenase-1; Inflammation; Kidney; Male; Mi	2006
Detection of human immunodeficiency virus induced inflammation and oxidative stress in lenticular nuclei with magnetic resonance spectroscopy despite antiretroviral therapy. Archives of neurology, 2007, Volume: 64, Issue:9 Topics: Adult; AIDS Dementia Complex; Antiretroviral Therapy, Highly Active; Aspartic Acid; Atrophy; Biomark	2007
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creatine and Innate Inflammatory Response