Page last updated: 2024-10-17

creatine and Infant, Premature, Diseases

creatine has been researched along with Infant, Premature, Diseases in 9 studies

Infant, Premature, Diseases: Diseases that occur in PREMATURE INFANTS.

Research Excerpts

ExcerptRelevanceReference
" Because these issues may be operative in apnea of prematurity (AOP), we hypothesized that CS reduces episodes of hypoxemia and bradycardia in infants with AOP."9.11Randomized, controlled trial of oral creatine supplementation (not effective) for apnea of prematurity. ( Bohnhorst, B; Dördelmann, M; Geuting, T; Peter, CS; Poets, CF; Wilken, B, 2004)
" Because these issues may be operative in apnea of prematurity (AOP), we hypothesized that CS reduces episodes of hypoxemia and bradycardia in infants with AOP."5.11Randomized, controlled trial of oral creatine supplementation (not effective) for apnea of prematurity. ( Bohnhorst, B; Dördelmann, M; Geuting, T; Peter, CS; Poets, CF; Wilken, B, 2004)

Research

Studies (9)

TimeframeStudies, this research(%)All Research%
pre-19902 (22.22)18.7374
1990's0 (0.00)18.2507
2000's4 (44.44)29.6817
2010's2 (22.22)24.3611
2020's1 (11.11)2.80

Authors

AuthorsStudies
Illapani, VSP1
Edmondson, DA1
Cecil, KM1
Altaye, M1
Kumar, M1
Harpster, K1
Parikh, NA1
Basu, SK1
Pradhan, S1
Kapse, K1
McCarter, R1
Murnick, J1
Chang, T1
Limperopoulos, C1
Gimpel, C1
Krause, A1
Franck, P1
Krueger, M1
von Schnakenburg, C1
Bohnhorst, B1
Geuting, T1
Peter, CS1
Dördelmann, M1
Wilken, B1
Poets, CF1
Gawlowski, Z1
Aladangady, N1
Coen, PG1
Csaicsich, D1
Russo-Schlaff, N1
Messerschmidt, A1
Weninger, M1
Pollak, A1
Aufricht, C1
Mathew, OP1
Jones, AS1
James, E1
Bland, H1
Groshong, T1
Vigneron, DB1
Barkovich, AJ1
Noworolski, SM1
von dem Bussche, M1
Henry, RG1
Lu, Y1
Partridge, JC1
Gregory, G1
Ferriero, DM1
Simon, HJ1
Axline, SG1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Early Sodium Intake in Preterm Newborns; Randomized Clinical Trial[NCT04035564]Phase 452 participants (Actual)Interventional2018-03-30Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

% Weight Change

The difference between initial weight and 72hrs weight, expressed in percentage of birth weight. (NCT04035564)
Timeframe: Initial weight (baseline) vs 72 hours

Intervention% of birth weight (Mean)
Sodium < 1mEq/kg/Day-9.206
Sodium 5mEq/kg/Day-6.345

Change in Serum Sodium

The difference between current serum sodium and initial serum sodium (NCT04035564)
Timeframe: Initial serum sodium (baseline) vs 72 hours

InterventionmEq/L (Mean)
Sodium < 1mEq/kg/Day1.921
Sodium 5mEq/kg/Day5.71

Hypernatremia

serum sodium >150mEq/L (NCT04035564)
Timeframe: 72 hours

InterventionParticipants (Count of Participants)
Sodium < 1mEq/kg/Day1
Sodium 5mEq/kg/Day1

Hyponatremia

serum sodium <130mEq/L (NCT04035564)
Timeframe: 72 hours

InterventionParticipants (Count of Participants)
Sodium < 1mEq/kg/Day6
Sodium 5mEq/kg/Day1

Mortality

Death during hospitalization. (NCT04035564)
Timeframe: Patients will be followed during hospitalization, an expected average of 3 months of age

InterventionParticipants (Count of Participants)
Sodium < 1mEq/kg/Day5
Sodium 5mEq/kg/Day2

Number of Participants With Intraventricular Hemorrhage

Bleeding into the brain´s ventricular system (intracranial ultrasound). (NCT04035564)
Timeframe: Patients will be followed during hospitalization, an expected average of 3 months of age

InterventionParticipants (Count of Participants)
Sodium < 1mEq/kg/Day6
Sodium 5mEq/kg/Day4

Number of Participants With Late-onset Sepsis

Positive blood culture and/or 5 days of continuous antimicrobial therapy (NCT04035564)
Timeframe: Patients will be followed during hospitalization, an expected average of 3 months of age

InterventionParticipants (Count of Participants)
Sodium < 1mEq/kg/Day8
Sodium 5mEq/kg/Day5

Number of Participants With Necrotizing Enterocolitis

"Number of patients with Bell stage II or greater necrotizing enterocolitis~Bell's Staging:~Stage II A:~Gastrointestinal signs: Increasing gastric aspirates, mild abdominal distention, fecal occult blood, absent bowel sounds.~Systemic signs: Temperature instability, apnea, bradycardia, lethargy. Radiological findings: Intestinal dilatation, ileus, pneumatosis intestinalis.~Stage II B:~Gastrointestinal signs: As stage IIA plus abdominal tenderness. Systemic signs: As stage IIA plus metabolic acidosis and thrombocytopenia. Radiological findings: As stage IIA plus portal vein gas and ascites.~Stage III A:~Gastrointestinal signs: As stage IIB plus marked abdominal tenderness and generalised peritonitis.~Systemic signs: As stage IIB plus hypotension and severe apnea. Radiological findings: As stage IIB~Stage III B:~Gastrointestinal signs: As stage IIIA As stage IIIA As stage IIIA plus pneumoperitoneum" (NCT04035564)
Timeframe: Patients will be followed during hospitalization, an expected average of 3 months of age

InterventionParticipants (Count of Participants)
Sodium < 1mEq/kg/Day2
Sodium 5mEq/kg/Day2

Weight Change

The difference between current weight and initial weight (NCT04035564)
Timeframe: Initial weight (baseline) vs 72 hours

InterventionGrams (Mean)
Sodium < 1mEq/kg/Day-135.43
Sodium 5mEq/kg/Day-96.05

Trials

1 trial available for creatine and Infant, Premature, Diseases

ArticleYear
Randomized, controlled trial of oral creatine supplementation (not effective) for apnea of prematurity.
    Pediatrics, 2004, Volume: 113, Issue:4

    Topics: Apnea; Bradycardia; Creatine; Double-Blind Method; Humans; Hypoxia; Infant, Newborn; Infant, Prematu

2004

Other Studies

8 other studies available for creatine and Infant, Premature, Diseases

ArticleYear
Magnetic resonance spectroscopy brain metabolites at term and 3-year neurodevelopmental outcomes in very preterm infants.
    Pediatric research, 2022, Volume: 92, Issue:1

    Topics: Brain; Child, Preschool; Choline; Creatine; Female; Fetal Growth Retardation; Humans; Infant; Infant

2022
Third Trimester Cerebellar Metabolite Concentrations are Decreased in Very Premature Infants with Structural Brain Injury.
    Scientific reports, 2019, 02-04, Volume: 9, Issue:1

    Topics: Aspartic Acid; Brain; Brain Injuries; Cerebellum; Choline; Creatine; Female; Gestational Age; Gray M

2019
Exposure to furosemide as the strongest risk factor for nephrocalcinosis in preterm infants.
    Pediatrics international : official journal of the Japan Pediatric Society, 2010, Volume: 52, Issue:1

    Topics: Birth Weight; Calcium; Creatine; Diuretics; Female; Furosemide; Gestational Age; Humans; Infant, New

2010
Hypernatraemia in preterm infants born at less than 27 weeks gestation.
    Journal of paediatrics and child health, 2006, Volume: 42, Issue:12

    Topics: Birth Weight; Creatine; Ductus Arteriosus, Patent; Enterocolitis, Necrotizing; Female; Fluid Therapy

2006
Renal failure, comorbidity and mortality in preterm infants.
    Wiener klinische Wochenschrift, 2008, Volume: 120, Issue:5-6

    Topics: Acute Kidney Injury; Austria; Cause of Death; Child, Preschool; Cohort Studies; Creatine; Female; Fo

2008
Neonatal renal failure: usefulness of diagnostic indices.
    Pediatrics, 1980, Volume: 65, Issue:1

    Topics: Acute Kidney Injury; Anuria; Creatine; Diagnosis, Differential; Gestational Age; Humans; Infant, New

1980
Three-dimensional proton MR spectroscopic imaging of premature and term neonates.
    AJNR. American journal of neuroradiology, 2001, Volume: 22, Issue:7

    Topics: Aspartic Acid; Brain; Brain Mapping; Cerebral Hemorrhage; Choline; Chorioamnionitis; Creatine; Energ

2001
Clinical pharmacology of kanamycin in premature infants.
    Annals of the New York Academy of Sciences, 1966, Jun-14, Volume: 132, Issue:2

    Topics: Adult; Creatine; Humans; Infant, Newborn; Infant, Premature, Diseases; Injections, Intramuscular; Ka

1966