creatine and Hypoxia
creatine has been researched along with Hypoxia in 76 studies
Hypoxia: Sub-optimal OXYGEN levels in the ambient air of living organisms.
Research Excerpts
| Excerpt | Relevance | Reference |
|---|---|---|
| "To determine whether creatine (Cr) supplementation improves muscle performance during exposure to acute hypobaric hypoxia." | 9.12 | Voluntary muscle function after creatine supplementation in acute hypobaric hypoxia. ( Baker-Fulco, CJ; Fulco, CS; Glickman, E; Kellogg, MD; Young, AJ, 2006) |
| " Because these issues may be operative in apnea of prematurity (AOP), we hypothesized that CS reduces episodes of hypoxemia and bradycardia in infants with AOP." | 9.11 | Randomized, controlled trial of oral creatine supplementation (not effective) for apnea of prematurity. ( Bohnhorst, B; Dördelmann, M; Geuting, T; Peter, CS; Poets, CF; Wilken, B, 2004) |
| "The aim of this study was to investigate the effects of direct creatine infusion on fetal systemic metabolic and cardiovascular responses to mild acute in utero hypoxia." | 8.02 | The physiological effects of creatine supplementation in fetal sheep before, during, and after umbilical cord occlusion and global hypoxia. ( Ellery, SJ; Hale, N; Muccini, AM; Nitsos, I; Snow, RJ; Tran, NT; Walker, DW, 2021) |
| "Creatine in density-fractionated red cells is not only a useful criterion of cell age but also an excellent indicator of erythropoietic dynamics particularly under the influence of present and past hypoxia." | 7.66 | Creatine in density-fractionated red cells, a useful indicator of erythropoietic dynamics and of hypoxia past and present. ( Daniel, A; Gross, J; Hartwig, A; Starck, H; Syllm-Rapoport, I, 1981) |
| "Adults rats exposed to hypoxia showed a definite increase of creatine concentration in red cells and plasma." | 7.66 | [Behavior of creatine in red blood cells and blood plasma of adult rats following exposure to hypoxia]. ( Daniel, A; Gross, J; Lun, A; Moller, R; Pohle, R; Syllm-Rapoport, I, 1980) |
| "The incidence of clinical seizures is highest in the newborn period." | 5.30 | Creatine increases survival and suppresses seizures in the hypoxic immature rat. ( Holtzman, D; Jensen, F; Khait, I; Togliatti, A, 1998) |
| "To determine whether creatine (Cr) supplementation improves muscle performance during exposure to acute hypobaric hypoxia." | 5.12 | Voluntary muscle function after creatine supplementation in acute hypobaric hypoxia. ( Baker-Fulco, CJ; Fulco, CS; Glickman, E; Kellogg, MD; Young, AJ, 2006) |
| " Because these issues may be operative in apnea of prematurity (AOP), we hypothesized that CS reduces episodes of hypoxemia and bradycardia in infants with AOP." | 5.11 | Randomized, controlled trial of oral creatine supplementation (not effective) for apnea of prematurity. ( Bohnhorst, B; Dördelmann, M; Geuting, T; Peter, CS; Poets, CF; Wilken, B, 2004) |
| "The aim of this study was to investigate the effects of direct creatine infusion on fetal systemic metabolic and cardiovascular responses to mild acute in utero hypoxia." | 4.02 | The physiological effects of creatine supplementation in fetal sheep before, during, and after umbilical cord occlusion and global hypoxia. ( Ellery, SJ; Hale, N; Muccini, AM; Nitsos, I; Snow, RJ; Tran, NT; Walker, DW, 2021) |
| "To determine the effects of hypoxia on energy state and intracellular pH (pHi) in resting pulmonary and systemic arterial smooth muscles, we used 31P nuclear magnetic resonance spectroscopy and colorimetric and enzymatic assays to measure pHi; intracellular concentrations of ATP, phosphocreatine, creatine, and Pi; and phosphorylation potential in superfused tissue segments from porcine proximal intrapulmonary and superficial femoral arteries." | 3.70 | Effects of hypoxia on energy state and pH in resting pulmonary and femoral arterial smooth muscles. ( Chacko, VP; Leach, RM; Sheehan, DW; Sylvester, JT, 1998) |
| "To address the hypothesis that impaired ATP synthesis rates caused by changes in the creatine kinase system is an important mechanism underlying cardiac failure, we measured total creatine kinase activity, isoenzyme composition and creatine content in two animal models of hypertrophy with cardiac dysfunction, the spontaneously hypertensive rat in the transition to failure and the creatine-depleted hyperthyroid rat heart challenged by hypoxia." | 3.68 | Energetic correlates of cardiac failure: changes in the creatine kinase system in the failing myocardium. ( Atkinson, DE; Clarke, K; Fetters, JK; Ingwall, JS, 1990) |
| "Creatine in density-fractionated red cells is not only a useful criterion of cell age but also an excellent indicator of erythropoietic dynamics particularly under the influence of present and past hypoxia." | 3.66 | Creatine in density-fractionated red cells, a useful indicator of erythropoietic dynamics and of hypoxia past and present. ( Daniel, A; Gross, J; Hartwig, A; Starck, H; Syllm-Rapoport, I, 1981) |
| "Adults rats exposed to hypoxia showed a definite increase of creatine concentration in red cells and plasma." | 3.66 | [Behavior of creatine in red blood cells and blood plasma of adult rats following exposure to hypoxia]. ( Daniel, A; Gross, J; Lun, A; Moller, R; Pohle, R; Syllm-Rapoport, I, 1980) |
| "Creatine is a naturally occurring compound involved in the buffering, transport, and regulation of cellular energy, with the potential to replenish cellular adenosine triphosphate without oxygen." | 2.80 | Creatine supplementation enhances corticomotor excitability and cognitive performance during oxygen deprivation. ( Byblow, WD; Gant, N; Turner, CE, 2015) |
| "Markers of nocturnal hypoxemia and SDB are associated with cerebral oxidative stress in older people at-risk for dementia, suggesting a potential mechanism by which SDB may contribute to brain degeneration, cognitive decline, and dementia." | 1.43 | Association of Anterior Cingulate Glutathione with Sleep Apnea in Older Adults At-Risk for Dementia. ( Cross, N; Duffy, SL; Grunstein, R; Hermens, DF; Hickie, IB; Lagopoulos, J; Lewis, SJ; Mowszowski, L; Naismith, SL; Terpening, Z, 2016) |
| "Myo-inositol (Myo-ins) is a marker of neuroglial cells, being present in the astrocytes of brain tissue, but also functions as an osmolyte." | 1.39 | Myo-inositol metabolism in appropriately grown and growth-restricted fetuses: a proton magnetic resonance spectroscopy study. ( Allsop, JM; Damodaram, MS; Kumar, S; Mcguinness, A; Patel, A; Rutherford, MA; Story, L; Supramaniam, V; Wylezinska, M, 2013) |
| "During seizures, CK-catalyzed fluxes increased only in GPA-fed mice." | 1.30 | In vivo brain phosphocreatine and ATP regulation in mice fed a creatine analog. ( Allred, E; Holtzman, D; Jensen, F; Khait, I; Meyers, R; O'Gorman, E; Wallimann, T, 1997) |
| "The incidence of clinical seizures is highest in the newborn period." | 1.30 | Creatine increases survival and suppresses seizures in the hypoxic immature rat. ( Holtzman, D; Jensen, F; Khait, I; Togliatti, A, 1998) |
| "During long-term (2-4 h) anoxia, the rate of IMP formation was less than 4% of that during contraction, despite similar changes in PCr, lactate, ADP, and AMP." | 1.28 | Influence of ATP turnover and metabolite changes on IMP formation and glycolysis in rat skeletal muscle. ( Edström, L; Gorski, J; Sahlin, K, 1990) |
Research
Studies (76)
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 34 (44.74) | 18.7374 |
| 1990's | 16 (21.05) | 18.2507 |
| 2000's | 10 (13.16) | 29.6817 |
| 2010's | 14 (18.42) | 24.3611 |
| 2020's | 2 (2.63) | 2.80 |
Authors
| Authors | Studies |
|---|---|
| Tran, NT | 2 |
| Kowalski, GM | 1 |
| Muccini, AM | 2 |
| Nitsos, I | 2 |
| Hale, N | 2 |
| Snow, RJ | 2 |
| Walker, DW | 2 |
| Ellery, SJ | 2 |
| Santacruz, L | 1 |
| Arciniegas, AJL | 1 |
| Darrabie, M | 1 |
| Mantilla, JG | 1 |
| Baron, RM | 1 |
| Bowles, DE | 1 |
| Mishra, R | 1 |
| Jacobs, DO | 1 |
| Conotte, S | 1 |
| Tassin, A | 1 |
| Conotte, R | 1 |
| Colet, JM | 1 |
| Zouaoui Boudjeltia, K | 1 |
| Legrand, A | 1 |
| Mazzone, AL | 1 |
| Baker, RA | 1 |
| McNicholas, K | 1 |
| Woodman, RJ | 1 |
| Michael, MZ | 1 |
| Gleadle, JM | 1 |
| Kim, KM | 1 |
| Kwon, SK | 1 |
| Kim, HY | 1 |
| Kim, SM | 1 |
| Kim, DH | 1 |
| Lee, HC | 1 |
| Story, L | 1 |
| Damodaram, MS | 1 |
| Supramaniam, V | 1 |
| Allsop, JM | 1 |
| Mcguinness, A | 1 |
| Patel, A | 1 |
| Wylezinska, M | 1 |
| Kumar, S | 1 |
| Rutherford, MA | 1 |
| Bogdanova, OV | 1 |
| Abdullah, O | 1 |
| Kanekar, S | 1 |
| Bogdanov, VB | 1 |
| Prescot, AP | 1 |
| Renshaw, PF | 1 |
| Kolpakova, ME | 1 |
| Veselkina, OS | 1 |
| Vlasov, TD | 1 |
| Turner, CE | 1 |
| Byblow, WD | 1 |
| Gant, N | 1 |
| Engl, E | 1 |
| Garvert, MM | 1 |
| Vestergaard, MB | 1 |
| Lindberg, U | 1 |
| Aachmann-Andersen, NJ | 1 |
| Lisbjerg, K | 1 |
| Christensen, SJ | 1 |
| Law, I | 1 |
| Rasmussen, P | 1 |
| Olsen, NV | 1 |
| Larsson, HBW | 1 |
| Duffy, SL | 1 |
| Lagopoulos, J | 1 |
| Terpening, Z | 1 |
| Lewis, SJ | 1 |
| Grunstein, R | 1 |
| Mowszowski, L | 1 |
| Cross, N | 1 |
| Hermens, DF | 1 |
| Hickie, IB | 1 |
| Naismith, SL | 1 |
| Scheer, M | 1 |
| Bischoff, AM | 1 |
| Kruzliak, P | 1 |
| Opatrilova, R | 1 |
| Bovell, D | 1 |
| Büsselberg, D | 1 |
| Esteva, S | 1 |
| Panisello, P | 1 |
| Casas, M | 1 |
| Torrella, JR | 1 |
| Pagés, T | 1 |
| Viscor, G | 1 |
| Adriano, E | 1 |
| Perasso, L | 2 |
| Panfoli, I | 1 |
| Ravera, S | 1 |
| Gandolfo, C | 2 |
| Mancardi, G | 1 |
| Morelli, A | 1 |
| Balestrino, M | 3 |
| Orsenigo, MN | 1 |
| Porta, C | 1 |
| Sironi, C | 1 |
| Laforenza, U | 1 |
| Meyer, G | 1 |
| Tosco, M | 1 |
| SUTTON, DC | 1 |
| SUTTON, GC | 1 |
| HINKENS, GF | 1 |
| BUCKINGHAM, WB | 1 |
| RONDINELLI, R | 1 |
| Benson, ES | 1 |
| Evans, GT | 1 |
| Phibbs, C | 1 |
| Freier, EF | 1 |
| DESPOPOULOS, A | 1 |
| KOLBER, J | 1 |
| Bohnhorst, B | 1 |
| Geuting, T | 1 |
| Peter, CS | 1 |
| Dördelmann, M | 1 |
| Wilken, B | 1 |
| Poets, CF | 1 |
| Raman, L | 1 |
| Tkac, I | 1 |
| Ennis, K | 1 |
| Georgieff, MK | 1 |
| Gruetter, R | 1 |
| Rao, R | 1 |
| Baker-Fulco, CJ | 1 |
| Fulco, CS | 1 |
| Kellogg, MD | 1 |
| Glickman, E | 1 |
| Young, AJ | 1 |
| Richards, JG | 1 |
| Wang, YS | 1 |
| Brauner, CJ | 1 |
| Gonzalez, RJ | 1 |
| Patrick, ML | 1 |
| Schulte, PM | 1 |
| Choppari-Gomes, AR | 1 |
| Almeida-Val, VM | 1 |
| Val, AL | 1 |
| Brito, J | 1 |
| Siqués, P | 1 |
| León-Velarde, F | 1 |
| De La Cruz, JJ | 1 |
| López, V | 1 |
| Herruzo, R | 1 |
| Lunardi, GL | 1 |
| Risso, F | 1 |
| Pohvozcheva, AV | 1 |
| Leko, MV | 1 |
| Florio, T | 1 |
| Cupello, A | 1 |
| Burov, SV | 1 |
| Gwak, M | 1 |
| Park, P | 1 |
| Kim, K | 1 |
| Lim, K | 1 |
| Jeong, S | 1 |
| Baek, C | 1 |
| Lee, J | 1 |
| Whittingham, TS | 1 |
| Lipton, P | 1 |
| Syllm-Rapoport, I | 3 |
| Daniel, A | 3 |
| Starck, H | 1 |
| Hartwig, A | 1 |
| Gross, J | 3 |
| Lun, A | 2 |
| Pohle, R | 1 |
| Moller, R | 1 |
| Jakobsson, P | 1 |
| Jorfeldt, L | 1 |
| Garde, K | 1 |
| Rostrup, E | 1 |
| Toft, PB | 1 |
| Henriksen, O | 1 |
| Carter, AJ | 2 |
| Müller, RE | 2 |
| Pschorn, U | 1 |
| Stransky, W | 1 |
| Hartmund, T | 1 |
| Gesser, H | 2 |
| Holtzman, D | 2 |
| Meyers, R | 1 |
| O'Gorman, E | 1 |
| Khait, I | 2 |
| Wallimann, T | 1 |
| Allred, E | 1 |
| Jensen, F | 2 |
| Jacobs, I | 1 |
| Bleue, S | 1 |
| Goodman, J | 1 |
| Togliatti, A | 1 |
| Leach, RM | 1 |
| Sheehan, DW | 1 |
| Chacko, VP | 1 |
| Sylvester, JT | 1 |
| Chateil, JF | 1 |
| Quesson, B | 1 |
| Brun, M | 1 |
| Thiaudière, E | 1 |
| Sarlangue, J | 1 |
| Delalande, C | 1 |
| Billeaud, C | 1 |
| Canioni, P | 1 |
| Diard, F | 1 |
| Toner, CC | 1 |
| Stamford, JA | 1 |
| Jensen, MA | 1 |
| Daneshrad, Z | 1 |
| Novel-Chaté, V | 1 |
| Birot, O | 1 |
| Serrurier, B | 1 |
| Sanchez, H | 1 |
| Bigard, AX | 1 |
| Rossi, A | 1 |
| Gore, CJ | 1 |
| Hahn, AG | 1 |
| Aughey, RJ | 1 |
| Martin, DT | 1 |
| Ashenden, MJ | 1 |
| Clark, SA | 1 |
| Garnham, AP | 1 |
| Roberts, AD | 1 |
| Slater, GJ | 1 |
| McKenna, MJ | 1 |
| Thillart, G | 1 |
| Kesbeke, F | 1 |
| Waarde, A | 1 |
| Kohn, MC | 1 |
| Achs, MJ | 1 |
| Garfinkel, D | 1 |
| Rau, EE | 1 |
| Shine, KI | 1 |
| Gervais, A | 1 |
| Douglas, AM | 1 |
| Amos, EC | 1 |
| Stefanovich, V | 1 |
| John, JP | 1 |
| Berlet, HH | 2 |
| Müller-Ruchholtz, ER | 1 |
| Neill, WA | 1 |
| O'Brien, JA | 1 |
| Nutbeam, AR | 1 |
| Vannucci, RC | 1 |
| Duffy, TE | 1 |
| Arthur, PG | 1 |
| Keen, JE | 1 |
| Hochachka, PW | 1 |
| Farrell, AP | 1 |
| Ingwall, JS | 1 |
| Atkinson, DE | 1 |
| Clarke, K | 1 |
| Fetters, JK | 1 |
| Sahlin, K | 1 |
| Gorski, J | 1 |
| Edström, L | 1 |
| Herpolsheimer, A | 1 |
| Krüger, I | 1 |
| Schmalisch, G | 1 |
| Zucchi, R | 1 |
| Poddighe, R | 1 |
| Limbruno, U | 1 |
| Mariani, M | 1 |
| Ronca-Testoni, S | 1 |
| Ronca, G | 1 |
| Matsuoka, S | 1 |
| Jarmakani, JM | 1 |
| Young, HH | 1 |
| Uemura, S | 1 |
| Nakanishi, T | 1 |
| Berne, RM | 1 |
| Belardinelli, L | 1 |
| Emoto, SE | 1 |
| Kintner, D | 1 |
| Feyzi, JM | 1 |
| Gilboe, DD | 1 |
| Kirsch, WM | 1 |
| Schulz, Q | 1 |
| Van Buskirk, J | 1 |
| Nakane, P | 1 |
| Gottesfeld, Z | 1 |
| Miller, AT | 1 |
| Haas, H | 1 |
| Gokel, M | 1 |
| Macmillan, V | 1 |
| Salford, LG | 2 |
| Siesjö, BK | 3 |
| Holmin, T | 1 |
| Dhalla, NS | 1 |
| Yates, JC | 1 |
| Walz, DA | 1 |
| McDonald, VA | 1 |
| Olson, RE | 1 |
| Biron, PE | 1 |
| Howard, J | 1 |
| Valeri, CR | 3 |
| Lippmann, HG | 1 |
| Kopriva, CJ | 1 |
| Fortier, NL | 1 |
| Janicki, J | 1 |
| Skupin, J | 1 |
| Giec, A | 1 |
| Prellwitz, W | 1 |
| Schuster, HP | 1 |
| Schylla, G | 1 |
| Baum, P | 1 |
| Schönborn, H | 1 |
| von Ungern-Sternberg, A | 1 |
| Brodersen, HC | 1 |
| Poeplau, W | 1 |
Clinical Trials (2)
Trial Overview
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Phase III Study of Metabolic Intervention With Glutamate in Coronary Surgery II[NCT02592824] | Phase 3 | 321 participants (Actual) | Interventional | 2015-11-15 | Completed | ||
| Phase III Study of Intravenous Glutamate Infusion for Metabolic Protection of the Heart in Surgery for Unstable Coronary Artery Disease[NCT00489827] | Phase 3 | 865 participants (Actual) | Interventional | 2005-10-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Trial Outcomes
Incidence of Mortality
Postoperative mortality was defined as mortality within 30 days of surgery. (NCT02592824)
Timeframe: up to 30 days
| Intervention | Participants (Count of Participants) |
|---|---|
| Intravenous Glutamate Infusion | 1 |
| Intravenous Saline Infusion | 6 |
Incidence of Unexpected Adverse Events
suspected unexpected serious adverse reaction (NCT02592824)
Timeframe: within 24 hours from infusion
| Intervention | Participants (Count of Participants) |
|---|---|
| Intravenous Glutamate Infusion | 0 |
| Intravenous Saline Infusion | 0 |
Number of Participants With Incidence of Stroke
"Postoperative stroke was defined as neurological or cognitive deficit with a cerebral injury verified on (Computed Tomography) CT-scan. All suspected cases of stroke underwent CT-scan.~Stroke within 24 h of surgery was defined as a stroke that occurred within 24 h of surgery or signs of a stroke, when first assessable in deeply sedated patients on a ventilator." (NCT02592824)
Timeframe: within 24 hours from surgery
| Intervention | Participants (Count of Participants) |
|---|---|
| Intravenous Glutamate Infusion | 0 |
| Intravenous Saline Infusion | 4 |
Postoperative Increase of Plasma NT-proBNP
"Postoperative increase of NT-proBNP reflects postoperative myocardial dysfunction sustained in association with surgery. NT-proBNP usually peaks on the third to fourth postoperative day after coronary artery bypass surgery.~In the first GLUTAMICS trial a good agreement between hemodynamic criteria for postoperative heart failure and postoperative NT-proBNP was found." (NCT02592824)
Timeframe: from the day before surgery to the third postoperative day
| Intervention | ng/L (Mean) |
|---|---|
| Intravenous Glutamate Infusion | 5390 |
| Intravenous Saline Infusion | 6452 |
Postoperative Increase of Plasma NT-proBNP in Patients Without Diabetes
"Postoperative increase of NT-proBNP reflects postoperative myocardial dysfunction sustained in association with surgery. NT-proBNP usually peaks on the third to fourth postoperative day after coronary artery bypass surgery.~Previous observations suggest a blunted effect of glutamate in diabetic hearts." (NCT02592824)
Timeframe: from preoperative level to the third postoperative day
| Intervention | ng/L (Mean) |
|---|---|
| Intravenous Glutamate Infusion | 4503 |
| Intravenous Saline Infusion | 6825 |
Postoperative Plasma Level of NT-proBNP
Postoperative NT-proBNP reflects postoperative myocardial dysfunction. (NCT02592824)
Timeframe: first postoperative day
| Intervention | ng/L (Mean) |
|---|---|
| Intravenous Glutamate Infusion | 4438 |
| Intravenous Saline Infusion | 4420 |
Postoperative Plasma Level of NT-proBNP
Postoperative NT-proBNP reflects postoperative myocardial dysfunction. (NCT02592824)
Timeframe: third postoperative day
| Intervention | ng/L (Mean) |
|---|---|
| Intravenous Glutamate Infusion | 8055 |
| Intravenous Saline Infusion | 8804 |
Atrial Fibrillation
Number of patients with atrial fibrillation recorded postoperatively (NCT00489827)
Timeframe: Hospital stay
| Intervention | Participants (Count of Participants) |
|---|---|
| Intravenous Glutamate | 147 |
| Saline Infusion | 152 |
ICU Stay
ICU duration of stay (hours) (NCT00489827)
Timeframe: ICU stay
| Intervention | hours (Median) |
|---|---|
| Intravenous Glutamate | 21 |
| Saline Infusion | 21 |
Number of Participants With Perioperative Myocardial Infarction, Postoperative Heart Failure or Postoperative Mortality
(NCT00489827)
Timeframe: 30 days
| Intervention | Participants (Count of Participants) |
|---|---|
| Intravenous Glutamate | 31 |
| Saline Infusion | 25 |
Number of Participants With Postoperative Stroke < 24 Hours
Incidence of Postoperative stroke < 24 hours of surgery verifed by CT-scan (NCT00489827)
Timeframe: 24 hours
| Intervention | Participants (Count of Participants) |
|---|---|
| Intravenous Glutamate | 4 |
| Saline Infusion | 6 |
Postoperative Hemodynamic State in Patients With Severely Reduced Left Ventricular Ejection Fraction (LVEF<0.40)
Hemodynamic instability despite inotropes or need for IABP at the end of surgery in patients with severely reduced left ventricular ejection fraction (LVEF<0.40) (NCT00489827)
Timeframe: End of surgery
| Intervention | Participants (Count of Participants) |
|---|---|
| Intravenous Glutamate | 1 |
| Saline Infusion | 5 |
Postoperative Renal Function
maximum p-creatinine value recorded postoperatively < 30 days (NCT00489827)
Timeframe: 30 days
| Intervention | µmol/L (Mean) |
|---|---|
| Intravenous Glutamate | 106 |
| Saline Infusion | 106 |
Severe Circulatory Failure in CCS Class IV Patients
Severe circulatory failure according to prespecified criteria as judged by a blinded endpoints committee in CCS class IV patients (NCT00489827)
Timeframe: 30 days
| Intervention | Participants (Count of Participants) |
|---|---|
| Intravenous Glutamate | 3 |
| Saline Infusion | 16 |
Degree of Perioperative Myocardial Injury
p-CK-MB postoperative day 1, p-troponin-T postoperative day 3 (NCT00489827)
Timeframe: perioperative
| Intervention | µg/L (Median) | |
|---|---|---|
| CK-MB day 1 | Troponin-T day 3 | |
| Intravenous Glutamate | 14 | 0.27 |
| Saline Infusion | 14 | 0.24 |
Postoperative Hemodynamic State
Mixed venous oxygen saturation (SvO2) measured at weaning from cardiopulmonary bypass and on arrival to ICU (NCT00489827)
Timeframe: Until arrival to ICU
| Intervention | percentage of saturated hemoglobin (Mean) | |
|---|---|---|
| SvO2 at weaning from CPB | SvO2 on arrival to ICU | |
| Intravenous Glutamate | 72.0 | 65.0 |
| Saline Infusion | 72.2 | 64.9 |
Reviews
2 reviews available for creatine and Hypoxia
| Article | Year |
|---|---|
[Creatine in a metabolism of cell and its protective action at brain ischemia].
Topics: Blood-Brain Barrier; Brain Ischemia; Creatine; Energy Metabolism; Humans; Hypoxia; Membrane Transpor | 2013 |
Anaerobic energy metabolism in brain tumors.
Topics: Adenosine Diphosphate; Adenosine Monophosphate; Adenosine Triphosphate; Aerobiosis; Anaerobiosis; An | 1972 |
Trials
5 trials available for creatine and Hypoxia
| Article | Year |
|---|---|
Creatine supplementation enhances corticomotor excitability and cognitive performance during oxygen deprivation.
Topics: Adult; Aspartic Acid; Blood Pressure; Cognition Disorders; Creatine; Dietary Supplements; Evoked Pot | 2015 |
Randomized, controlled trial of oral creatine supplementation (not effective) for apnea of prematurity.
Topics: Apnea; Bradycardia; Creatine; Double-Blind Method; Humans; Hypoxia; Infant, Newborn; Infant, Prematu | 2004 |
Voluntary muscle function after creatine supplementation in acute hypobaric hypoxia.
Topics: Adult; Analysis of Variance; Creatine; Cross-Over Studies; Double-Blind Method; Exercise Test; Human | 2006 |
Long-term oxygen therapy may improve skeletal muscle metabolism in advanced chronic obstructive pulmonary disease patients with chronic hypoxaemia.
Topics: Adenosine Triphosphate; Aged; Creatine; Energy Metabolism; Female; Glycogen; Humans; Hypoxia; Lactat | 1995 |
Creatine ingestion increases anaerobic capacity and maximum accumulated oxygen deficit.
Topics: Administration, Oral; Adult; Anaerobic Threshold; Creatine; Double-Blind Method; Energy Metabolism; | 1997 |
Other Studies
69 other studies available for creatine and Hypoxia
| Article | Year |
|---|---|
Creatine supplementation reduces the cerebral oxidative and metabolic stress responses to acute in utero hypoxia in the late-gestation fetal sheep.
Topics: Animals; Creatine; Dietary Supplements; Female; Fetal Hypoxia; Fetus; Glycerol; Humans; Hypoxia; Lac | 2022 |
The physiological effects of creatine supplementation in fetal sheep before, during, and after umbilical cord occlusion and global hypoxia.
Topics: Animals; Creatine; Dietary Supplements; Female; Fetus; Hypoxia; Pregnancy; Sheep; Umbilical Cord | 2021 |
Hypoxia decreases creatine uptake in cardiomyocytes, while creatine supplementation enhances HIF activation.
Topics: Adaptation, Physiological; Adenosine Triphosphate; AMP-Activated Protein Kinase Kinases; Animals; Ce | 2017 |
Metabonomic profiling of chronic intermittent hypoxia in a mouse model.
Topics: Analysis of Variance; Animals; Creatine; Disease Models, Animal; Glucose Tolerance Test; Guanidinoac | 2018 |
Circulating and Urinary miR-210 and miR-16 Increase during Cardiac Surgery Using Cardiopulmonary Bypass - A Pilot Study.
Topics: Cardiac Surgical Procedures; Cardiopulmonary Bypass; Creatine; Hemoglobins; Hemolysis; Humans; Hypox | 2018 |
A case of immersion-induced acute kidney injury: did momentary hypoxia affect tubular damage?
Topics: Acute Kidney Injury; Adult; Biopsy; Creatine; Humans; Hypoxia; Male; Near Drowning; Time Factors | 2018 |
Myo-inositol metabolism in appropriately grown and growth-restricted fetuses: a proton magnetic resonance spectroscopy study.
Topics: Astrocytes; Brain; Case-Control Studies; Creatine; Female; Fetal Growth Retardation; Fetus; Humans; | 2013 |
Neurochemical alterations in frontal cortex of the rat after one week of hypobaric hypoxia.
Topics: Alanine; Altitude; Animals; Corpus Striatum; Creatine; Depressive Disorder; Female; Frontal Lobe; Gl | 2014 |
A Prophylactic Role for Creatine in Hypoxia?
Topics: Cognition Disorders; Creatine; Dietary Supplements; Female; Humans; Hypoxia; Male; Motor Cortex; Neu | 2015 |
Acute hypoxia increases the cerebral metabolic rate - a magnetic resonance imaging study.
Topics: Adolescent; Adult; Brain; Cerebrovascular Circulation; Creatine; Energy Metabolism; Glutamic Acid; H | 2016 |
Association of Anterior Cingulate Glutathione with Sleep Apnea in Older Adults At-Risk for Dementia.
Topics: Aged; Aging; Biomarkers; Cognition Disorders; Cognitive Dysfunction; Creatine; Dementia; Depression; | 2016 |
Creatine and creatine pyruvate reduce hypoxia-induced effects on phrenic nerve activity in the juvenile mouse respiratory system.
Topics: Aging; Animals; Creatine; Hypoxia; Mice; Motor Activity; Phrenic Nerve; Pyruvic Acid; Respiratory Sy | 2016 |
Morphofunctional responses to anaemia in rat skeletal muscle.
Topics: Adenosine Triphosphate; Anemia; Animals; Capillaries; Creatine; Histocytochemistry; Hypoxia; Lactic | 2008 |
A novel hypothesis about mechanisms affecting conduction velocity of central myelinated fibers.
Topics: Adenosine Triphosphate; Animals; Creatine; Enzyme Inhibitors; Gap Junctions; Hippocampus; Humans; Hy | 2011 |
Effects of creatine in a rat intestinal model of ischemia/reperfusion injury.
Topics: Animals; Antioxidants; Creatine; Gene Expression Regulation; HSP70 Heat-Shock Proteins; Hypoxia; Ile | 2012 |
Studies on whole blood and muscle creatine levels; effect of systemic and local anoxia, of cardiac failure and compensation, and of alpha-tocopherol administration.
Topics: alpha-Tocopherol; Blood; Creatine; Heart Failure; Humans; Hypoxia; Male; Muscles; Testis; Vitamin E | 1954 |
Myocardial creatine phosphate and nucleotides in aoxic cardiac arrest and recovery.
Topics: Creatine; Creatinine; Heart Arrest; Humans; Hypoxia; Myocardium; Nucleosides; Nucleotides; Phosphocr | 1961 |
NON-COMPETITIVE NON-INHIBITORY INTERACTION BETWEEN HIPPURATE AND CREATININE IN THE KIDNEY.
Topics: Acetates; Animals; Biological Transport; Creatine; Creatinine; Hippurates; Hypoxia; Kidney; Metaboli | 1964 |
In vivo effect of chronic hypoxia on the neurochemical profile of the developing rat hippocampus.
Topics: Age Factors; Analysis of Variance; Animals; Animals, Newborn; Aspartic Acid; Body Weight; Brain Chem | 2005 |
Metabolic and ionoregulatory responses of the Amazonian cichlid, Astronotus ocellatus, to severe hypoxia.
Topics: Adaptation, Physiological; Adenosine Triphosphate; Animals; Blood Glucose; Cichlids; Creatine; Eryth | 2007 |
Chronic intermittent hypoxia at high altitude exposure for over 12 years: assessment of hematological, cardiovascular, and renal effects.
Topics: Acclimatization; Adult; Altitude; Altitude Sickness; Blood Pressure; Chile; Cholesterol; Chronic Dis | 2007 |
Protective effects of some creatine derivatives in brain tissue anoxia.
Topics: Animals; Creatine; Hypoxia; In Vitro Techniques; Mice | 2008 |
The effects of dantrolene on hypoxic-ischemic injury in the neonatal rat brain.
Topics: Animals; Animals, Newborn; Apoptosis; Aspartic Acid; Brain; Carotid Artery, Common; Creatine; Dantro | 2008 |
Cerebral synaptic transmission during anoxia is protected by creatine.
Topics: Anaerobiosis; Animals; Creatine; Evoked Potentials; Guinea Pigs; Hippocampus; Hypoxia; In Vitro Tech | 1981 |
Creatine in density-fractionated red cells, a useful indicator of erythropoietic dynamics and of hypoxia past and present.
Topics: Adult; Centrifugation, Density Gradient; Child; Creatine; Erythrocytes; Erythropoiesis; Humans; Hypo | 1981 |
[Behavior of creatine in red blood cells and blood plasma of adult rats following exposure to hypoxia].
Topics: Animals; Creatine; Erythrocytes; Erythropoiesis; Hypoxia; Plasma; Rats | 1980 |
Pathophysiology of anoxic depolarization: new findings and a working hypothesis.
Topics: Adenosine Triphosphate; Animals; Cell Hypoxia; Creatine; Electrophysiology; Hippocampus; Hypoxia; Ma | 1995 |
Cerebral energy metabolism during hypoxaemia. A 31P and 1H magnetic resonance study.
Topics: Adult; Aspartic Acid; Brain; Choline; Creatine; Energy Metabolism; Hemodynamics; Humans; Hydrogen-Io | 1995 |
Preincubation with creatine enhances levels of creatine phosphate and prevents anoxic damage in rat hippocampal slices.
Topics: Animals; Creatine; Energy Metabolism; Guanidines; Hippocampus; Hypoxia; In Vitro Techniques; Male; N | 1995 |
Cardiac force and high-energy phosphates under metabolic inhibition in four ectothermic vertebrates.
Topics: Adenosine Diphosphate; Adenosine Monophosphate; Adenosine Triphosphate; Animals; Creatine; Creatine | 1996 |
In vivo brain phosphocreatine and ATP regulation in mice fed a creatine analog.
Topics: Adenosine Triphosphate; Animals; Brain; Creatine; Creatine Kinase; Diet; Female; Guanidines; Hypoxia | 1997 |
Creatine increases survival and suppresses seizures in the hypoxic immature rat.
Topics: Animals; Creatine; Humans; Hypoxia; Rats; Seizures; Survival Analysis | 1998 |
Effects of hypoxia on energy state and pH in resting pulmonary and femoral arterial smooth muscles.
Topics: Adenosine Triphosphate; Animals; Creatine; Energy Metabolism; Femoral Artery; Hydrogen; Hydrogen-Ion | 1998 |
Localised proton magnetic resonance spectroscopy of the brain after perinatal hypoxia: a preliminary report.
Topics: Aspartic Acid; Asphyxia; Brain; Choline; Creatine; Follow-Up Studies; Humans; Hypoxia; Infant, Newbo | 1999 |
Effects of metabolic alterations on dopamine release in an in vitro model of neostriatal ischaemia.
Topics: Animals; Brain Ischemia; Creatine; Dopamine; Electrophysiology; Hypoxia; In Vitro Techniques; Male; | 1999 |
Influence of inorganic phosphate and energy state on force in skinned cardiac muscle from freshwater turtle and rainbow trout.
Topics: Adenosine Diphosphate; Animals; Creatine; Energy Metabolism; Hypoxia; In Vitro Techniques; Myocardia | 1999 |
Diet restriction plays an important role in the alterations of heart mitochondrial function following exposure of young rats to chronic hypoxia.
Topics: Adenosine Diphosphate; Animals; Atmospheric Pressure; Body Weight; Citrate (si)-Synthase; Creatine; | 2001 |
Live high:train low increases muscle buffer capacity and submaximal cycling efficiency.
Topics: Adaptation, Physiological; Adenosine Triphosphate; Adult; Altitude; Atmosphere Exposure Chambers; Bi | 2001 |
Influence of anoxia on the energy metabolism of goldfish Carassius auratus (L.).
Topics: Adenosine Diphosphate; Adenosine Monophosphate; Adenosine Triphosphate; Alanine; Animals; Carbon Dio | 1976 |
Distribution of adenine nucleotides in the perfused rat heart.
Topics: Actins; Adenine Nucleotides; Animals; Computers; Coronary Disease; Creatine; Cytosol; Glucose; Hydro | 1977 |
Enhanced mechanical recovery of anoxic and ischemic myocardium by amino acid perfusion.
Topics: Amino Acids; Animals; Arginine; Aspartic Acid; Coronary Disease; Creatine; Glutamates; Hypoxia; Male | 1979 |
Enhanced mechanical recovery of anoxic and ischemic myocardium by amino acid perfusion.
Topics: Amino Acids; Animals; Arginine; Aspartic Acid; Coronary Disease; Creatine; Glutamates; Hypoxia; Male | 1979 |
Enhanced mechanical recovery of anoxic and ischemic myocardium by amino acid perfusion.
Topics: Amino Acids; Animals; Arginine; Aspartic Acid; Coronary Disease; Creatine; Glutamates; Hypoxia; Male | 1979 |
Enhanced mechanical recovery of anoxic and ischemic myocardium by amino acid perfusion.
Topics: Amino Acids; Animals; Arginine; Aspartic Acid; Coronary Disease; Creatine; Glutamates; Hypoxia; Male | 1979 |
Influence of pentifylline on brain metabolism of normal and anoxic rats.
Topics: Adenine Nucleotides; Animals; Brain; Carbohydrate Metabolism; Creatine; Female; Hypoxia; Rats; Theob | 1978 |
Hypoxic survival of normoglycaemic young adult and adult mice in relation to cerebral metabolic rates.
Topics: Adenine Nucleotides; Animals; Brain; Creatine; Energy Metabolism; Glucose; Glycogen; Glycolysis; Hyp | 1976 |
The mechanism of coronary hyperemia induced by increased cardiac work.
Topics: Adenine Nucleotides; Animals; Cardiac Output; Coronary Circulation; Creatine; Guinea Pigs; Hyperemia | 1976 |
Creatine release from the isolated perfused rat heart.
Topics: Aerobiosis; Animals; Creatine; Hypoxia; Male; Myocardium; Perfusion; Rats | 1975 |
Uptake and phosphorylation of (14C) creatine by mouse cardiac muscle in vivo.
Topics: Animals; Biological Transport; Creatine; Diaphragm; Hypoxia; Kinetics; Male; Mice; Muscles; Myocardi | 1975 |
Carbohydrate metabolism in fetal and neonatal rat brain during anoxia and recovery.
Topics: Adenosine Triphosphate; Animals; Brain; Carbohydrate Metabolism; Creatine; Glucose; Glycogen; Glycol | 1976 |
Metabolic state of the in situ perfused trout heart during severe hypoxia.
Topics: Adenosine Triphosphate; Animals; Blood Pressure; Cardiac Output; Coronary Circulation; Creatine; Fem | 1992 |
Energetic correlates of cardiac failure: changes in the creatine kinase system in the failing myocardium.
Topics: Animals; Cardiac Output, Low; Cardiomegaly; Creatine; Creatine Kinase; Hypoxia; Isoenzymes; Mitochon | 1990 |
Application and validation of an ion-exchange high-performance liquid chromatographic method for measuring adenine nucleotides, creatine and creatine phosphate in mouse brain.
Topics: Adenine Nucleotides; Animals; Brain Chemistry; Chromatography, High Pressure Liquid; Creatine; Hypox | 1990 |
Influence of ATP turnover and metabolite changes on IMP formation and glycolysis in rat skeletal muscle.
Topics: Adenosine Diphosphate; Adenosine Monophosphate; Adenosine Triphosphate; Animals; Creatine; Energy Me | 1990 |
Creatine and density of red blood cells in perinatal hypoxia.
Topics: Animals; Animals, Newborn; Child; Creatine; Erythrocyte Volume; Erythrocytes; Erythropoiesis; Female | 1987 |
Protection of isolated rat heart from oxidative stress by exogenous creatine phosphate.
Topics: Animals; Coronary Disease; Creatine; Heart; Hemodynamics; Hydrogen Peroxide; Hypoxia; In Vitro Techn | 1989 |
The effect of glutamate on hypoxic newborn rabbit heart.
Topics: Adenosine Triphosphate; Animals; Animals, Newborn; Creatine; Glutamates; Glutamic Acid; Glycolysis; | 1986 |
Effects of hypoxia and ischaemia on coronary vascular resistance, A-V node conduction and S-A node excitation.
Topics: Adenine Nucleotides; Adenosine; Aminophylline; Atrioventricular Node; Coronary Circulation; Coronary | 1985 |
Relating cerebral ischemia and hypoxia to insult intensity.
Topics: Adenine Nucleotides; Animals; Brain; Cerebrovascular Circulation; Creatine; Dogs; Glucose; Glycogen; | 1988 |
Metabolic response of rat brain to acute hypoxia: influence of polycythemia and hypercapnia.
Topics: Adenosine Triphosphate; Animals; Brain; Brain Chemistry; Creatine; Hypercapnia; Hypoxia; Lactates; M | 1969 |
[Effect of Verapamil on the metabolism of myocardium].
Topics: Adenine Nucleotides; Adenosine Triphosphate; Animals; Anti-Arrhythmia Agents; Asphyxia; Blood Glucos | 1970 |
Metabolic state and blood flow in rat cerebral cortex, cerebellum and brainstem in hypoxic hypoxia.
Topics: Adenosine Diphosphate; Adenosine Monophosphate; Adenosine Triphosphate; Animals; Blood Pressure; Bod | 1974 |
The influence of arterial hypoxia and unilateral carotid artery occlusion upon regional blood flow and metabolism in the rat brain.
Topics: Adenosine Diphosphate; Adenosine Monophosphate; Adenosine Triphosphate; Animals; Brain; Carbon Dioxi | 1974 |
Influence of hypoxia on cerebral energy state in rats with porta-caval anastomosis.
Topics: Adenosine Diphosphate; Adenosine Monophosphate; Adenosine Triphosphate; Ammonia; Animals; Aspartic A | 1974 |
Correlation between changes in the endogenous energy stores and myocardial function due to hypoxia in the isolated perfused rat heart.
Topics: Adenine Nucleotides; Animals; Cholesterol; Coronary Circulation; Creatine; Electric Stimulation; Ele | 1972 |
Chronic deficits in red-cell mass in patients with orthopaedic injuries (stress anemia).
Topics: Adult; Anemia; Arm Injuries; Blood Preservation; Blood Transfusion; Blood Volume; Chromium Isotopes; | 1972 |
[High energy phosphates, glucose, lactate, and pyruvate in rat brain under varying pO2].
Topics: Adenine Nucleotides; Adenosine Diphosphate; Adenosine Monophosphate; Adenosine Triphosphate; Age Fac | 1971 |
Oxyhemoglobin dissociation curve in hemorrhagic and septic shock.
Topics: Adult; Anemia; Blood Transfusion; Cardiac Output; Creatine; Diphosphoglyceric Acids; Erythrocytes; F | 1971 |
2,3-Diphosphoglycerate in trauma. In: Energy metabolism in trauma.
Topics: Animals; Creatine; Dogs; Erythrocytes; Glycerophosphates; Humans; Hypoxia; Oxygen Consumption; Rats; | 1970 |
Red-cell 2,3-diphosphoglycerate and creatine levels in patients with red-cell mass deficits or with cardiopulmonary insufficiency.
Topics: Adolescent; Adult; Aged; Creatine; Erythrocytes; Glycerophosphates; Heart Failure; Hematologic Disea | 1969 |
[Present state of research on pangamic acid (Vitamin B 15)].
Topics: Antidotes; Creatine; Humans; Hypoxia; Poisons; Vitamin B Complex; Vitamin B Deficiency | 1970 |
[Differential diagnosis of organ involvement in exogenous poisoning by means of clinical and clinico-chemical studies].
Topics: Alanine Transaminase; Alcohol Oxidoreductases; Aspartate Aminotransferases; Barbiturates; Blood Chem | 1970 |