Page last updated: 2024-10-17

creatine and Hypertrophy

creatine has been researched along with Hypertrophy in 29 studies

Hypertrophy: General increase in bulk of a part or organ due to CELL ENLARGEMENT and accumulation of FLUIDS AND SECRETIONS, not due to tumor formation, nor to an increase in the number of cells (HYPERPLASIA).

Research Excerpts

ExcerptRelevanceReference
"Creatine supplementation, immediately before or immediately after unilateral resistance training, produces similar gains in muscle hypertrophy and strength in young adults."9.41Timing of creatine supplementation does not influence gains in unilateral muscle hypertrophy or strength from resistance training in young adults: a within-subject design. ( Candow, DG; Forbes, SC; Krentz, JR, 2021)
"The purpose of this paper was to carry out a systematic review with a meta-analysis of randomized controlled trials that examined the combined effects of resistance training (RT) and creatine supplementation on regional changes in muscle mass, with direct imaging measures of hypertrophy."9.41The Effects of Creatine Supplementation Combined with Resistance Training on Regional Measures of Muscle Hypertrophy: A Systematic Review with Meta-Analysis. ( Aragon, AA; Augustin, F; Burke, R; Candow, DG; Coleman, M; Forbes, SC; Mohan, A; Piñero, A; Sapuppo, M; Schoenfeld, BJ; Swinton, P, 2023)
" Our aim was to evaluate the changes in the protein kinase R-like endoplasmic reticulum kinase (PERK) arm of the UPR and hypertrophy signaling pathway following 8 weeks of resistance training and creatine (Cr) supplementation in rats."8.02Changes in UPR-PERK pathway and muscle hypertrophy following resistance training and creatine supplementation in rats. ( Moloudi, MR; Nouri, H; Sheikholeslami-Vatani, D, 2021)
"The purpose of this study was to examine the effect of creatine supplementation in conjunction with resistance training on physiological adaptations including muscle fiber hypertrophy and muscle creatine accumulation."5.09Performance and muscle fiber adaptations to creatine supplementation and heavy resistance training. ( Duncan, ND; Fink, WJ; Gómez, AL; Kraemer, WJ; Mazzetti, SA; Pearson, DR; Putukian, M; Staron, RS; Volek, JS, 1999)
"Creatine has been used to maximize resistance training effects on skeletal muscles, including muscle hypertrophy and fiber type changes."4.31Effects of Creatine Supplementation on the Myostatin Pathway and Myosin Heavy Chain Isoforms in Different Skeletal Muscles of Resistance-Trained Rats. ( Damatto, FC; de Carvalho, MR; de Morais, CS; de Oliveira Filiú, WF; de Oliveira-Junior, SA; Duarte, EF; Gaspar-Junior, JJ; Martinez, PF; Mendonça, MLM; Okoshi, K; Okoshi, MP; Oliveira, RJ; Ota, GE, 2023)
"This study investigated the effect of dietary creatine supplementation on hypertrophy and performance of rat skeletal muscle."3.74The effect of creatine supplementation on mass and performance of rat skeletal muscle. ( Young, JC; Young, RE, 2007)
" In megacolon the following occur: 1) structural remodeling expressed as a greater increase in the fraction of maximum force production at short lengths, a shift of optimum length (Lo) to longer lengths, and no change in force per square centimeter; 2) hypertrophy and hyperplasia of both circular and longitudinal muscle; 3) high resting compliance consistent with no disproportionate change in collagen or elastin composition; 4) marked distension so that in situ circumference approximately 1."3.69Hypertrophy of colonic smooth muscle: structural remodeling, chemical composition, and force output. ( Butler, TM; Mooers, SU; Narayan, S; Siegman, MJ; Starcher, BC; Stirewalt, WS; Trinkle-Mulcahy, L, 1997)
"We present a case of infantile onset Krabbe disease with prolonged survival, initial intracranial optic nerves and optic chiasm hypertrophy, and serial changes on cranial magnetic resonance imaging and magnetic resonance spectroscopy."1.38Prolonged survival and serial magnetic resonance imaging/magnetic resonance spectroscopy changes in infantile Krabbe disease. ( Bunge, M; Mhanni, AA; Ryner, L; Salman, MS; Udow, S, 2012)
"After a successful treatment of the nephrotic syndrome with steroids, there was no enlargement of the JGC complex."1.25The size of the juxtaglomerular apparatus in glomerulonephritis with the nephrotic syndrome: a morphometrical study of renal biopsies. ( Hara, M; Meyer, D, 1975)

Research

Studies (29)

TimeframeStudies, this research(%)All Research%
pre-19909 (31.03)18.7374
1990's4 (13.79)18.2507
2000's9 (31.03)29.6817
2010's3 (10.34)24.3611
2020's4 (13.79)2.80

Authors

AuthorsStudies
Forbes, SC2
Krentz, JR1
Candow, DG2
Burke, R1
Piñero, A1
Coleman, M1
Mohan, A1
Sapuppo, M1
Augustin, F1
Aragon, AA1
Swinton, P1
Schoenfeld, BJ1
de Carvalho, MR1
Duarte, EF1
Mendonça, MLM1
de Morais, CS1
Ota, GE1
Gaspar-Junior, JJ1
de Oliveira Filiú, WF1
Damatto, FC1
Okoshi, MP1
Okoshi, K1
Oliveira, RJ1
Martinez, PF1
de Oliveira-Junior, SA1
Nouri, H1
Sheikholeslami-Vatani, D1
Moloudi, MR1
Aguiar, AF1
de Souza, RW1
Aguiar, DH1
Aguiar, RC1
Vechetti, IJ1
Dal-Pai-Silva, M1
Do Amaral, VC1
Simões, Mde J1
Marcondes, RR1
Matozinho Cubas, JJ1
Baracat, EC1
Soares, JM1
Udow, S1
Bunge, M1
Ryner, L1
Mhanni, AA1
Salman, MS1
GANGLOFF, EC1
HEMMINGS, IL1
KRAUSE, RF1
SILVER, HK1
SCHROEDER, FA1
Joly, E1
Nonclercq, D1
Caron, N1
Mertens, J1
Flamion, B1
Toubeau, G1
Kramp, R1
Bouby, N1
Koudijs, SM1
van der Grond, J1
Hoogendoorn, ML1
Hulshoff Pol, HE1
Schnack, HG1
Witkamp, TD1
Gooskens, RH1
van Nieuwenhuizen, O1
Braun, KP1
Cribb, PJ1
Hayes, A1
Young, RE1
Young, JC1
Rous, SN1
Wakim, KG1
Siegman, MJ1
Butler, TM1
Mooers, SU1
Trinkle-Mulcahy, L1
Narayan, S1
Stirewalt, WS1
Starcher, BC1
Yang, CW1
Yu, CC1
Ko, YC1
Huang, CC1
Volek, JS1
Duncan, ND1
Mazzetti, SA1
Staron, RS1
Putukian, M1
Gómez, AL1
Pearson, DR1
Fink, WJ1
Kraemer, WJ1
Dangott, B1
Schultz, E1
Mozdziak, PE1
Gibala, MJ1
Deicken, RF1
Eliaz, Y1
Feiwell, R1
Schuff, N1
Eijnde, BO1
Hespel, P1
Stevenson, SW1
Dudley, GA1
Ingwall, JS1
Morales, MF1
Stockdale, FE1
Wildenthal, K1
Hofmann, WW1
Butte, J1
Leon, HA1
Hara, M1
Meyer, D1
Rogozkin, VA1
Shimamura, T1
Garcia-Caceres, U1
Ortega, J1
Rossmann, P1
Hurych, J1

Reviews

2 reviews available for creatine and Hypertrophy

ArticleYear
The Effects of Creatine Supplementation Combined with Resistance Training on Regional Measures of Muscle Hypertrophy: A Systematic Review with Meta-Analysis.
    Nutrients, 2023, Apr-28, Volume: 15, Issue:9

    Topics: Aged; Creatine; Dietary Supplements; Humans; Hypertrophy; Muscles; Resistance Training

2023
Nutritional supplementation and resistance exercise: what is the evidence for enhanced skeletal muscle hypertrophy?
    Canadian journal of applied physiology = Revue canadienne de physiologie appliquee, 2000, Volume: 25, Issue:6

    Topics: Amino Acids; Creatine; Dietary Carbohydrates; Dietary Supplements; Fasting; Humans; Hypertrophy; Ins

2000

Trials

5 trials available for creatine and Hypertrophy

ArticleYear
Timing of creatine supplementation does not influence gains in unilateral muscle hypertrophy or strength from resistance training in young adults: a within-subject design.
    The Journal of sports medicine and physical fitness, 2021, Volume: 61, Issue:9

    Topics: Adolescent; Adult; Creatine; Dietary Supplements; Female; Humans; Hypertrophy; Male; Muscle Strength

2021
Effects of supplement timing and resistance exercise on skeletal muscle hypertrophy.
    Medicine and science in sports and exercise, 2006, Volume: 38, Issue:11

    Topics: Absorptiometry, Photon; Adult; Biopsy, Needle; Body Composition; Contractile Proteins; Creatine; Die

2006
Performance and muscle fiber adaptations to creatine supplementation and heavy resistance training.
    Medicine and science in sports and exercise, 1999, Volume: 31, Issue:8

    Topics: Adaptation, Physiological; Adult; Body Composition; Creatine; Dietary Supplements; Double-Blind Meth

1999
Short-term creatine supplementation does not alter the hormonal response to resistance training.
    Medicine and science in sports and exercise, 2001, Volume: 33, Issue:3

    Topics: Administration, Oral; Adult; Creatine; Cross-Over Studies; Dietary Supplements; Double-Blind Method;

2001
Dietary creatine supplementation and muscular adaptation to resistive overload.
    Medicine and science in sports and exercise, 2001, Volume: 33, Issue:8

    Topics: Adult; Biomechanical Phenomena; Creatine; Dietary Supplements; Electric Stimulation Therapy; Ergonom

2001

Other Studies

22 other studies available for creatine and Hypertrophy

ArticleYear
Effects of Creatine Supplementation on the Myostatin Pathway and Myosin Heavy Chain Isoforms in Different Skeletal Muscles of Resistance-Trained Rats.
    Nutrients, 2023, May-08, Volume: 15, Issue:9

    Topics: Animals; Creatine; Dietary Supplements; Follistatin; Hypertrophy; Male; Muscle, Skeletal; Myosin Hea

2023
Changes in UPR-PERK pathway and muscle hypertrophy following resistance training and creatine supplementation in rats.
    Journal of physiology and biochemistry, 2021, Volume: 77, Issue:2

    Topics: Activating Transcription Factor 4; Adaptation, Physiological; Animals; Creatine; Dietary Supplements

2021
Creatine does not promote hypertrophy in skeletal muscle in supplemented compared with nonsupplemented rats subjected to a similar workload.
    Nutrition research (New York, N.Y.), 2011, Volume: 31, Issue:8

    Topics: Animals; Creatine; Dietary Supplements; Hypertrophy; Male; Muscle Fibers, Skeletal; Muscle, Skeletal

2011
Histomorphometric analysis of the effects of creatine on rat myometrium.
    Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology, 2012, Volume: 28, Issue:8

    Topics: Animals; Creatine; Diestrus; Dietary Supplements; Endometrium; Female; Hypertrophy; Myometrium; Orga

2012
Prolonged survival and serial magnetic resonance imaging/magnetic resonance spectroscopy changes in infantile Krabbe disease.
    Pediatric neurology, 2012, Volume: 47, Issue:4

    Topics: Anticonvulsants; Aspartic Acid; Brain Chemistry; Choline; Combined Modality Therapy; Creatine; DNA M

2012
Creatine, creatinine, and creatine phosphate in normal and hypertrophied rat hearts.
    The American journal of physiology, 1961, Volume: 201

    Topics: Cardiomegaly; Coenzymes; Creatine; Creatinine; Hypertrophy; Phosphocreatine

1961
CONGENITAL MUSCULAR HYPERTROPHY. AN ASSOCIATION WITH INCREASED URINARY MUCOPOLYSACCHARIDES.
    American journal of diseases of children (1960), 1964, Volume: 108

    Topics: Carbohydrate Metabolism; Carbohydrate Metabolism, Inborn Errors; Child; Creatine; Creatinine; Diagno

1964
Differential regulation of angiotensin II receptors during renal injury and compensatory hypertrophy in the rat.
    Clinical and experimental pharmacology & physiology, 2005, Volume: 32, Issue:4

    Topics: Animals; Body Weight; Creatine; Down-Regulation; Eating; Hypertrophy; Immunohistochemistry; Kidney;

2005
MRI, volumetry, 1H spectroscopy, and cerebropetal blood flowmetry in childhood idiopathic anatomic megalencephaly.
    Journal of magnetic resonance imaging : JMRI, 2006, Volume: 24, Issue:2

    Topics: Aspartic Acid; Blood Flow Velocity; Brain; Brain Diseases; Case-Control Studies; Cerebrovascular Cir

2006
The effect of creatine supplementation on mass and performance of rat skeletal muscle.
    Life sciences, 2007, Aug-09, Volume: 81, Issue:9

    Topics: Animals; Creatine; Dietary Supplements; Electric Stimulation; Hypertrophy; Male; Muscle Strength; Mu

2007
Kidney function before, during and after compensatory hypertrophy.
    The Journal of urology, 1967, Volume: 98, Issue:1

    Topics: Aminohippuric Acids; Animals; Creatine; Dogs; Hypertrophy; Kidney; Kidney Function Tests; Nephrectom

1967
Hypertrophy of colonic smooth muscle: structural remodeling, chemical composition, and force output.
    The American journal of physiology, 1997, Volume: 272, Issue:6 Pt 1

    Topics: Actins; Adenine Nucleotides; Aging; Animals; Collagen; Colon; Creatine; Creatinine; Elastin; Electri

1997
Aminoguanidine reduces glomerular inducible nitric oxide synthase (iNOS) and transforming growth factor-beta 1 (TGF-beta1) mRNA expression and diminishes glomerulosclerosis in NZB/W F1 mice.
    Clinical and experimental immunology, 1998, Volume: 113, Issue:2

    Topics: Animals; Body Weight; Cell Count; Creatine; Crosses, Genetic; Enzyme Inhibitors; Female; Guanidines;

1998
Dietary creatine monohydrate supplementation increases satellite cell mitotic activity during compensatory hypertrophy.
    International journal of sports medicine, 2000, Volume: 21, Issue:1

    Topics: Administration, Oral; Animals; Body Composition; Bromodeoxyuridine; Creatine; Dietary Supplements; H

2000
Increased thalamic N-acetylaspartate in male patients with familial bipolar I disorder.
    Psychiatry research, 2001, Feb-28, Volume: 106, Issue:1

    Topics: Adult; Aspartic Acid; Bipolar Disorder; Choline; Creatine; Humans; Hypertrophy; Magnetic Resonance S

2001
Creatine: a possible stimulus skeletal cardiac muscle hypertrophy.
    Recent advances in studies on cardiac structure and metabolism, 1975, Volume: 8

    Topics: Actins; Animals; Cardiomegaly; Chick Embryo; Creatine; Culture Techniques; DNA; Hypertrophy; Leucine

1975
Relationship of intracellular creatine concentration and uptake to muscle mass in vivo.
    The American journal of physiology, 1978, Volume: 235, Issue:5

    Topics: Animals; Atrophy; Biological Transport, Active; Creatine; Hypertrophy; Male; Muscle Contraction; Mus

1978
The size of the juxtaglomerular apparatus in glomerulonephritis with the nephrotic syndrome: a morphometrical study of renal biopsies.
    Virchows Archiv. A, Pathological anatomy and histology, 1975, Jun-23, Volume: 367, Issue:1

    Topics: Age Factors; Basement Membrane; Biometry; Creatine; Diuretics; Glomerulonephritis; Humans; Hypertens

1975
The role of low molecular weight compounds in the regulation of skeletal muscle genome activity during exercise.
    Medicine and science in sports, 1976,Spring, Volume: 8, Issue:1

    Topics: Amino Acids; Animals; Creatine; DNA-Directed RNA Polymerases; Hypertrophy; Male; Muscle Proteins; Mu

1976
Prevention of 11-deoxycorticosterone-salt-induced glomerular hypertrophy and glomerulosclerosis by dietary phosphate binder.
    The American journal of pathology, 1990, Volume: 136, Issue:3

    Topics: Aluminum Hydroxide; Animals; Antacids; Blood Pressure; Calcium; Creatine; Desoxycorticosterone; Dise

1990
Studies of tubular alterations in diffuse renal disease. II. Quantitative evaluation of cellularity and length of proximal convoluted tubules in the kidney of lupus nephritis.
    The American journal of pathology, 1967, Volume: 50, Issue:6

    Topics: Albuminuria; Blood Urea Nitrogen; Cell Nucleus; Creatine; Humans; Hypertrophy; Kidney Tubules; Lupus

1967
Influence of preexistent pyelonephritis on the development and manifestations of acute fatal glomerulonephritis.
    International urology and nephrology, 1973, Volume: 5, Issue:1

    Topics: Acute Disease; Adult; Arteriosclerosis; Blood Pressure; Creatine; Edema; Female; Glomerulonephritis;

1973