creatine has been researched along with Hepatic Encephalopathy in 20 studies
Hepatic Encephalopathy: A syndrome characterized by central nervous system dysfunction in association with LIVER FAILURE, including portal-systemic shunts. Clinical features include lethargy and CONFUSION (frequently progressing to COMA); ASTERIXIS; NYSTAGMUS, PATHOLOGIC; brisk oculovestibular reflexes; decorticate and decerebrate posturing; MUSCLE SPASTICITY; and bilateral extensor plantar reflexes (see REFLEX, BABINSKI). ELECTROENCEPHALOGRAPHY may demonstrate triphasic waves. (From Adams et al., Principles of Neurology, 6th ed, pp1117-20; Plum & Posner, Diagnosis of Stupor and Coma, 3rd ed, p222-5)
| Excerpt | Relevance | Reference |
|---|---|---|
| " Hepatic encephalopathy (HE) is characterized by abnormal cerebral metabolites, yet the response to lactulose and other anti-HE measures is still primarily determined by using arbitrary categorical clinical rating scales, rather than MR spectroscopy." | 7.70 | Proton MR spectroscopic measurement of neurometabolites in hepatic encephalopathy during oral lactulose therapy. ( Agarwal, VP; Haseler, LJ; McCarthy, DM; Mojtahedzadeh, HN; Reddy, S; Sibbitt, WL, 1998) |
| " Among a number of clinical and laboratory variables analyzed, the only independent predictive factors of overt HE were hyponatremia (serum sodium < 130 mEq / l), history of overt HE, serum bilirubin,and serum creatinine." | 3.75 | Hyponatremia is a risk factor of hepatic encephalopathy in patients with cirrhosis: a prospective study with time-dependent analysis. ( Arroyo, V; Baccaro, ME; Ginès, P; Gómez-Ansón, B; Guevara, M; Martín-Llahí, M; Monté-Rubio, GC; Rami, L; Ríos, J; Torre, A; Torres, F, 2009) |
| " Hepatic encephalopathy (HE) is characterized by abnormal cerebral metabolites, yet the response to lactulose and other anti-HE measures is still primarily determined by using arbitrary categorical clinical rating scales, rather than MR spectroscopy." | 3.70 | Proton MR spectroscopic measurement of neurometabolites in hepatic encephalopathy during oral lactulose therapy. ( Agarwal, VP; Haseler, LJ; McCarthy, DM; Mojtahedzadeh, HN; Reddy, S; Sibbitt, WL, 1998) |
| "Brain alterations such as hepatic encephalopathy or brain edema are usually associated with liver failure." | 2.50 | Magnetic resonance of the brain in chronic and acute liver failure. ( Chavarria, L; Cordoba, J, 2014) |
| "The sequence of events in hepatic encephalopathy (HE) remains unclear." | 1.51 | Longitudinal neurometabolic changes in the hippocampus of a rat model of chronic hepatic encephalopathy. ( Braissant, O; Cudalbu, C; Grosse, J; McLin, VA; Pierzchala, K; Rackayová, V, 2019) |
| "Hepatic encephalopathy is associated with a regional specific decrease of GABA levels in the visual cortex, while no changes were revealed for the sensorimotor cortex." | 1.42 | Low visual cortex GABA levels in hepatic encephalopathy: links to blood ammonia, critical flicker frequency, and brain osmolytes. ( Baumgarten, TJ; Butz, M; Hoogenboom, N; Oeltzschner, G; Schnitzler, A; Wittsack, HJ, 2015) |
| "To develop a reliable surgical model of acute hepatic failure and hyperammonemia in rats that avoids porto-systemic shunt and bile duct ligation, applicable to hepatic encephalopathy research." | 1.36 | A new experimental model for acute hepatic failure in rats. ( Bellodi-Privato, M; D'Albuquerque, LA; Kubrusly, MS; Leite, KR; Machado, MC; Molan, NT; Teixeira, AR, 2010) |
| "Cerebral edema is present in patients with MHE." | 1.36 | Effect of surgical portosystemic shunt on prevalence of minimal hepatic encephalopathy in children with extrahepatic portal venous obstruction: assessment by magnetic resonance imaging and psychometry. ( Gupta, RK; Lal, R; Saraswat, VA; Srivastava, A; Thomas, MA; Yachha, SK; Yadav, SK, 2010) |
| "Acute-on-chronic liver failure (ACLF), acute liver failure (ALF) and chronic liver disease (CLD) are common forms of liver failure and present with similar clinical profiles." | 1.35 | In vivo 1H magnetic resonance spectroscopy-derived metabolite variations between acute-on-chronic liver failure and acute liver failure. ( Gupta, RK; Nath, K; Radha Krishna, Y; Saraswat, VA; Thomas, MA; Verma, A, 2008) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 3 (15.00) | 18.2507 |
| 2000's | 6 (30.00) | 29.6817 |
| 2010's | 10 (50.00) | 24.3611 |
| 2020's | 1 (5.00) | 2.80 |
| Authors | Studies |
|---|---|
| Asaki, Y | 1 |
| Murofushi, Y | 1 |
| Yasukawa, K | 1 |
| Hara, M | 1 |
| Takanashi, JI | 1 |
| Braissant, O | 1 |
| Rackayová, V | 1 |
| Pierzchala, K | 1 |
| Grosse, J | 1 |
| McLin, VA | 1 |
| Cudalbu, C | 1 |
| Chavarria, L | 1 |
| Cordoba, J | 1 |
| Razek, AA | 1 |
| Abdalla, A | 1 |
| Ezzat, A | 1 |
| Megahed, A | 1 |
| Barakat, T | 1 |
| Meng, LP | 1 |
| Chen, YC | 1 |
| Li, YH | 1 |
| Zhu, JS | 1 |
| Ye, JL | 1 |
| Oeltzschner, G | 2 |
| Butz, M | 2 |
| Baumgarten, TJ | 1 |
| Hoogenboom, N | 1 |
| Wittsack, HJ | 2 |
| Schnitzler, A | 2 |
| Wickrath, F | 1 |
| Guevara, M | 1 |
| Baccaro, ME | 1 |
| Torre, A | 1 |
| Gómez-Ansón, B | 1 |
| Ríos, J | 1 |
| Torres, F | 1 |
| Rami, L | 1 |
| Monté-Rubio, GC | 1 |
| Martín-Llahí, M | 1 |
| Arroyo, V | 1 |
| Ginès, P | 1 |
| Singhal, A | 1 |
| Nagarajan, R | 1 |
| Kumar, R | 1 |
| Huda, A | 1 |
| Gupta, RK | 4 |
| Thomas, MA | 4 |
| Teixeira, AR | 1 |
| Machado, MC | 1 |
| Kubrusly, MS | 1 |
| Molan, NT | 1 |
| Bellodi-Privato, M | 1 |
| Leite, KR | 1 |
| D'Albuquerque, LA | 1 |
| Herman-Sucharska, I | 1 |
| Grzybek, M | 1 |
| Grochowska, A | 1 |
| Karcz, P | 1 |
| Urbanik, A | 1 |
| Srivastava, A | 1 |
| Yadav, SK | 1 |
| Lal, R | 1 |
| Yachha, SK | 1 |
| Saraswat, VA | 3 |
| Bokemeyer, M | 1 |
| Ding, XQ | 1 |
| Goldbecker, A | 1 |
| Raab, P | 2 |
| Heeren, M | 1 |
| Arvanitis, D | 1 |
| Tillmann, HL | 1 |
| Lanfermann, H | 1 |
| Weissenborn, K | 1 |
| Saksena, S | 1 |
| Rai, V | 1 |
| Rathore, RS | 1 |
| Purwar, A | 1 |
| Kumar, M | 1 |
| Verma, A | 1 |
| Radha Krishna, Y | 1 |
| Nath, K | 1 |
| Danielsen, ER | 1 |
| Michaelis, T | 1 |
| Ross, BD | 1 |
| Laubenberger, J | 1 |
| Bayer, S | 1 |
| Thiel, T | 1 |
| Hennig, J | 1 |
| Langer, M | 1 |
| Haseler, LJ | 1 |
| Sibbitt, WL | 1 |
| Mojtahedzadeh, HN | 1 |
| Reddy, S | 1 |
| Agarwal, VP | 1 |
| McCarthy, DM | 1 |
| Naegele, T | 1 |
| Grodd, W | 1 |
| Viebahn, R | 1 |
| Seeger, U | 1 |
| Klose, U | 1 |
| Seitz, D | 1 |
| Kaiser, S | 1 |
| Mader, I | 1 |
| Mayer, J | 1 |
| Lauchart, W | 1 |
| Gregor, M | 1 |
| Voigt, K | 1 |
| Delcker, A | 1 |
| Turowski, B | 1 |
| Mihm, U | 1 |
| Rusch, O | 1 |
| Pilatus, U | 1 |
| Zeuzem, S | 1 |
| Zanella, FE | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Role of Magnetic Resonance Imaging in Detection of Minimal Hepatic Encephalopathy[NCT04131205] | 40 participants (Anticipated) | Observational | 2019-06-01 | Recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 review available for creatine and Hepatic Encephalopathy
| Article | Year |
|---|---|
Magnetic resonance of the brain in chronic and acute liver failure.
Topics: Aspartic Acid; Biomarkers; Brain; Brain Chemistry; Brain Edema; Choline; Creatine; Glutamic Acid; Gl | 2014 |
1 trial available for creatine and Hepatic Encephalopathy
| Article | Year |
|---|---|
Minimal hepatic encephalopathy in children with liver cirrhosis: diffusion-weighted MR imaging and proton MR spectroscopy of the brain.
Topics: Adolescent; Child; Choline; Creatine; Diffusion Magnetic Resonance Imaging; Female; Glutamic Acid; H | 2014 |
18 other studies available for creatine and Hepatic Encephalopathy
| Article | Year |
|---|---|
Neurochemistry of hyponatremic encephalopathy evaluated by MR spectroscopy.
Topics: Aspartic Acid; Child; Creatine; Glutamic Acid; Glutamine; Hepatic Encephalopathy; Humans; Hyponatrem | 2020 |
Longitudinal neurometabolic changes in the hippocampus of a rat model of chronic hepatic encephalopathy.
Topics: Ammonium Compounds; Animals; Ascorbic Acid; Astrocytes; Chronic Disease; Creatine; Disease Models, A | 2019 |
Viability assessment of magnetic resonance spectroscopy for the detection of minimal hepatic encephalopathy severity.
Topics: Adult; Aspartic Acid; Basal Ganglia; Brain; Cognition; Creatine; Female; Glutamic Acid; Glutamine; G | 2015 |
Low visual cortex GABA levels in hepatic encephalopathy: links to blood ammonia, critical flicker frequency, and brain osmolytes.
Topics: Ammonia; Brain Chemistry; Creatine; Female; Flicker Fusion; gamma-Aminobutyric Acid; Glutamine; Glyc | 2015 |
Covert hepatic encephalopathy: elevated total glutathione and absence of brain water content changes.
Topics: Aged; Ammonia; Brain; Brain Edema; Creatine; Female; Glutathione; Hepatic Encephalopathy; Humans; Ma | 2016 |
Hyponatremia is a risk factor of hepatic encephalopathy in patients with cirrhosis: a prospective study with time-dependent analysis.
Topics: Adult; Aged; Aspartic Acid; Bilirubin; Brain Chemistry; Creatine; Creatinine; Female; Follow-Up Stud | 2009 |
Magnetic resonance T2-relaxometry and 2D L-correlated spectroscopy in patients with minimal hepatic encephalopathy.
Topics: Adult; Aged; Brain; Choline; Creatine; Female; Hepatic Encephalopathy; Humans; Inositol; Liver; Magn | 2009 |
A new experimental model for acute hepatic failure in rats.
Topics: Ammonia; Animals; Bilirubin; Creatine; Disease Models, Animal; Hepatectomy; Hepatic Encephalopathy; | 2010 |
[Myoinositol trends in HMRS brain spectrum of patients with hepatic encephalopathy].
Topics: Ammonia; Biomarkers; Choline; Creatine; Hepatic Encephalopathy; Humans; Inositol; Liver; Magnetic Re | 2010 |
Effect of surgical portosystemic shunt on prevalence of minimal hepatic encephalopathy in children with extrahepatic portal venous obstruction: assessment by magnetic resonance imaging and psychometry.
Topics: Adolescent; Ammonia; Brain Edema; Child; Creatine; Cross-Sectional Studies; Female; Glutamine; Hepat | 2010 |
Evidence for neuroinflammation and neuroprotection in HCV infection-associated encephalopathy.
Topics: Adult; Aged; Aspartic Acid; Brain; Brain Mapping; Case-Control Studies; Choline; Cognition Disorders | 2011 |
Cerebral diffusion tensor imaging and in vivo proton magnetic resonance spectroscopy in patients with fulminant hepatic failure.
Topics: Adolescent; Adult; Anisotropy; Aspartic Acid; Biomarkers; Case-Control Studies; Cerebrovascular Circ | 2008 |
In vivo 1H magnetic resonance spectroscopy-derived metabolite variations between acute-on-chronic liver failure and acute liver failure.
Topics: Adolescent; Adult; Aged; Aspartic Acid; Brain; Case-Control Studies; Choline; Chronic Disease; Creat | 2008 |
Three methods of calibration in quantitative proton MR spectroscopy.
Topics: Adult; Aspartic Acid; Body Water; Brain; Brain Chemistry; Brain Injuries; Calibration; Choline; Crea | 1995 |
[Clinical uses of proton magnetic resonance spectroscopy of the brain].
Topics: AIDS Dementia Complex; Alzheimer Disease; Animals; Aspartic Acid; Brain; Brain Diseases; Brain Disea | 1998 |
Proton MR spectroscopic measurement of neurometabolites in hepatic encephalopathy during oral lactulose therapy.
Topics: Administration, Oral; Adult; Brain; Choline; Creatine; Glutamic Acid; Glutamine; Hepatic Encephalopa | 1998 |
MR imaging and (1)H spectroscopy of brain metabolites in hepatic encephalopathy: time-course of renormalization after liver transplantation.
Topics: Adult; Basal Ganglia; Choline; Creatine; Energy Metabolism; Female; Glutamic Acid; Glutamine; Hepati | 2000 |
Proton MR spectroscopy of neurometabolites in hepatic encephalopathy during L-ornithine-L-aspartate treatment--results of a pilot study.
Topics: Aged; Brain; Creatine; Dipeptides; Female; Glutamic Acid; Glutamine; Hepatic Encephalopathy; Humans; | 2002 |