Page last updated: 2024-10-17

creatine and Hepatic Encephalopathy

creatine has been researched along with Hepatic Encephalopathy in 20 studies

Hepatic Encephalopathy: A syndrome characterized by central nervous system dysfunction in association with LIVER FAILURE, including portal-systemic shunts. Clinical features include lethargy and CONFUSION (frequently progressing to COMA); ASTERIXIS; NYSTAGMUS, PATHOLOGIC; brisk oculovestibular reflexes; decorticate and decerebrate posturing; MUSCLE SPASTICITY; and bilateral extensor plantar reflexes (see REFLEX, BABINSKI). ELECTROENCEPHALOGRAPHY may demonstrate triphasic waves. (From Adams et al., Principles of Neurology, 6th ed, pp1117-20; Plum & Posner, Diagnosis of Stupor and Coma, 3rd ed, p222-5)

Research Excerpts

ExcerptRelevanceReference
" Hepatic encephalopathy (HE) is characterized by abnormal cerebral metabolites, yet the response to lactulose and other anti-HE measures is still primarily determined by using arbitrary categorical clinical rating scales, rather than MR spectroscopy."7.70Proton MR spectroscopic measurement of neurometabolites in hepatic encephalopathy during oral lactulose therapy. ( Agarwal, VP; Haseler, LJ; McCarthy, DM; Mojtahedzadeh, HN; Reddy, S; Sibbitt, WL, 1998)
" Among a number of clinical and laboratory variables analyzed, the only independent predictive factors of overt HE were hyponatremia (serum sodium < 130 mEq / l), history of overt HE, serum bilirubin,and serum creatinine."3.75Hyponatremia is a risk factor of hepatic encephalopathy in patients with cirrhosis: a prospective study with time-dependent analysis. ( Arroyo, V; Baccaro, ME; Ginès, P; Gómez-Ansón, B; Guevara, M; Martín-Llahí, M; Monté-Rubio, GC; Rami, L; Ríos, J; Torre, A; Torres, F, 2009)
" Hepatic encephalopathy (HE) is characterized by abnormal cerebral metabolites, yet the response to lactulose and other anti-HE measures is still primarily determined by using arbitrary categorical clinical rating scales, rather than MR spectroscopy."3.70Proton MR spectroscopic measurement of neurometabolites in hepatic encephalopathy during oral lactulose therapy. ( Agarwal, VP; Haseler, LJ; McCarthy, DM; Mojtahedzadeh, HN; Reddy, S; Sibbitt, WL, 1998)
"Brain alterations such as hepatic encephalopathy or brain edema are usually associated with liver failure."2.50Magnetic resonance of the brain in chronic and acute liver failure. ( Chavarria, L; Cordoba, J, 2014)
"The sequence of events in hepatic encephalopathy (HE) remains unclear."1.51Longitudinal neurometabolic changes in the hippocampus of a rat model of chronic hepatic encephalopathy. ( Braissant, O; Cudalbu, C; Grosse, J; McLin, VA; Pierzchala, K; Rackayová, V, 2019)
"Hepatic encephalopathy is associated with a regional specific decrease of GABA levels in the visual cortex, while no changes were revealed for the sensorimotor cortex."1.42Low visual cortex GABA levels in hepatic encephalopathy: links to blood ammonia, critical flicker frequency, and brain osmolytes. ( Baumgarten, TJ; Butz, M; Hoogenboom, N; Oeltzschner, G; Schnitzler, A; Wittsack, HJ, 2015)
"To develop a reliable surgical model of acute hepatic failure and hyperammonemia in rats that avoids porto-systemic shunt and bile duct ligation, applicable to hepatic encephalopathy research."1.36A new experimental model for acute hepatic failure in rats. ( Bellodi-Privato, M; D'Albuquerque, LA; Kubrusly, MS; Leite, KR; Machado, MC; Molan, NT; Teixeira, AR, 2010)
"Cerebral edema is present in patients with MHE."1.36Effect of surgical portosystemic shunt on prevalence of minimal hepatic encephalopathy in children with extrahepatic portal venous obstruction: assessment by magnetic resonance imaging and psychometry. ( Gupta, RK; Lal, R; Saraswat, VA; Srivastava, A; Thomas, MA; Yachha, SK; Yadav, SK, 2010)
"Acute-on-chronic liver failure (ACLF), acute liver failure (ALF) and chronic liver disease (CLD) are common forms of liver failure and present with similar clinical profiles."1.35In vivo 1H magnetic resonance spectroscopy-derived metabolite variations between acute-on-chronic liver failure and acute liver failure. ( Gupta, RK; Nath, K; Radha Krishna, Y; Saraswat, VA; Thomas, MA; Verma, A, 2008)

Research

Studies (20)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's3 (15.00)18.2507
2000's6 (30.00)29.6817
2010's10 (50.00)24.3611
2020's1 (5.00)2.80

Authors

AuthorsStudies
Asaki, Y1
Murofushi, Y1
Yasukawa, K1
Hara, M1
Takanashi, JI1
Braissant, O1
Rackayová, V1
Pierzchala, K1
Grosse, J1
McLin, VA1
Cudalbu, C1
Chavarria, L1
Cordoba, J1
Razek, AA1
Abdalla, A1
Ezzat, A1
Megahed, A1
Barakat, T1
Meng, LP1
Chen, YC1
Li, YH1
Zhu, JS1
Ye, JL1
Oeltzschner, G2
Butz, M2
Baumgarten, TJ1
Hoogenboom, N1
Wittsack, HJ2
Schnitzler, A2
Wickrath, F1
Guevara, M1
Baccaro, ME1
Torre, A1
Gómez-Ansón, B1
Ríos, J1
Torres, F1
Rami, L1
Monté-Rubio, GC1
Martín-Llahí, M1
Arroyo, V1
Ginès, P1
Singhal, A1
Nagarajan, R1
Kumar, R1
Huda, A1
Gupta, RK4
Thomas, MA4
Teixeira, AR1
Machado, MC1
Kubrusly, MS1
Molan, NT1
Bellodi-Privato, M1
Leite, KR1
D'Albuquerque, LA1
Herman-Sucharska, I1
Grzybek, M1
Grochowska, A1
Karcz, P1
Urbanik, A1
Srivastava, A1
Yadav, SK1
Lal, R1
Yachha, SK1
Saraswat, VA3
Bokemeyer, M1
Ding, XQ1
Goldbecker, A1
Raab, P2
Heeren, M1
Arvanitis, D1
Tillmann, HL1
Lanfermann, H1
Weissenborn, K1
Saksena, S1
Rai, V1
Rathore, RS1
Purwar, A1
Kumar, M1
Verma, A1
Radha Krishna, Y1
Nath, K1
Danielsen, ER1
Michaelis, T1
Ross, BD1
Laubenberger, J1
Bayer, S1
Thiel, T1
Hennig, J1
Langer, M1
Haseler, LJ1
Sibbitt, WL1
Mojtahedzadeh, HN1
Reddy, S1
Agarwal, VP1
McCarthy, DM1
Naegele, T1
Grodd, W1
Viebahn, R1
Seeger, U1
Klose, U1
Seitz, D1
Kaiser, S1
Mader, I1
Mayer, J1
Lauchart, W1
Gregor, M1
Voigt, K1
Delcker, A1
Turowski, B1
Mihm, U1
Rusch, O1
Pilatus, U1
Zeuzem, S1
Zanella, FE1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Role of Magnetic Resonance Imaging in Detection of Minimal Hepatic Encephalopathy[NCT04131205]40 participants (Anticipated)Observational2019-06-01Recruiting
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

1 review available for creatine and Hepatic Encephalopathy

ArticleYear
Magnetic resonance of the brain in chronic and acute liver failure.
    Metabolic brain disease, 2014, Volume: 29, Issue:4

    Topics: Aspartic Acid; Biomarkers; Brain; Brain Chemistry; Brain Edema; Choline; Creatine; Glutamic Acid; Gl

2014

Trials

1 trial available for creatine and Hepatic Encephalopathy

ArticleYear
Minimal hepatic encephalopathy in children with liver cirrhosis: diffusion-weighted MR imaging and proton MR spectroscopy of the brain.
    Neuroradiology, 2014, Volume: 56, Issue:10

    Topics: Adolescent; Child; Choline; Creatine; Diffusion Magnetic Resonance Imaging; Female; Glutamic Acid; H

2014

Other Studies

18 other studies available for creatine and Hepatic Encephalopathy

ArticleYear
Neurochemistry of hyponatremic encephalopathy evaluated by MR spectroscopy.
    Brain & development, 2020, Volume: 42, Issue:10

    Topics: Aspartic Acid; Child; Creatine; Glutamic Acid; Glutamine; Hepatic Encephalopathy; Humans; Hyponatrem

2020
Longitudinal neurometabolic changes in the hippocampus of a rat model of chronic hepatic encephalopathy.
    Journal of hepatology, 2019, Volume: 71, Issue:3

    Topics: Ammonium Compounds; Animals; Ascorbic Acid; Astrocytes; Chronic Disease; Creatine; Disease Models, A

2019
Viability assessment of magnetic resonance spectroscopy for the detection of minimal hepatic encephalopathy severity.
    European journal of radiology, 2015, Volume: 84, Issue:10

    Topics: Adult; Aspartic Acid; Basal Ganglia; Brain; Cognition; Creatine; Female; Glutamic Acid; Glutamine; G

2015
Low visual cortex GABA levels in hepatic encephalopathy: links to blood ammonia, critical flicker frequency, and brain osmolytes.
    Metabolic brain disease, 2015, Volume: 30, Issue:6

    Topics: Ammonia; Brain Chemistry; Creatine; Female; Flicker Fusion; gamma-Aminobutyric Acid; Glutamine; Glyc

2015
Covert hepatic encephalopathy: elevated total glutathione and absence of brain water content changes.
    Metabolic brain disease, 2016, Volume: 31, Issue:3

    Topics: Aged; Ammonia; Brain; Brain Edema; Creatine; Female; Glutathione; Hepatic Encephalopathy; Humans; Ma

2016
Hyponatremia is a risk factor of hepatic encephalopathy in patients with cirrhosis: a prospective study with time-dependent analysis.
    The American journal of gastroenterology, 2009, Volume: 104, Issue:6

    Topics: Adult; Aged; Aspartic Acid; Bilirubin; Brain Chemistry; Creatine; Creatinine; Female; Follow-Up Stud

2009
Magnetic resonance T2-relaxometry and 2D L-correlated spectroscopy in patients with minimal hepatic encephalopathy.
    Journal of magnetic resonance imaging : JMRI, 2009, Volume: 30, Issue:5

    Topics: Adult; Aged; Brain; Choline; Creatine; Female; Hepatic Encephalopathy; Humans; Inositol; Liver; Magn

2009
A new experimental model for acute hepatic failure in rats.
    Acta cirurgica brasileira, 2010, Volume: 25, Issue:3

    Topics: Ammonia; Animals; Bilirubin; Creatine; Disease Models, Animal; Hepatectomy; Hepatic Encephalopathy;

2010
[Myoinositol trends in HMRS brain spectrum of patients with hepatic encephalopathy].
    Przeglad lekarski, 2010, Volume: 67, Issue:4

    Topics: Ammonia; Biomarkers; Choline; Creatine; Hepatic Encephalopathy; Humans; Inositol; Liver; Magnetic Re

2010
Effect of surgical portosystemic shunt on prevalence of minimal hepatic encephalopathy in children with extrahepatic portal venous obstruction: assessment by magnetic resonance imaging and psychometry.
    Journal of pediatric gastroenterology and nutrition, 2010, Volume: 51, Issue:6

    Topics: Adolescent; Ammonia; Brain Edema; Child; Creatine; Cross-Sectional Studies; Female; Glutamine; Hepat

2010
Evidence for neuroinflammation and neuroprotection in HCV infection-associated encephalopathy.
    Gut, 2011, Volume: 60, Issue:3

    Topics: Adult; Aged; Aspartic Acid; Brain; Brain Mapping; Case-Control Studies; Choline; Cognition Disorders

2011
Cerebral diffusion tensor imaging and in vivo proton magnetic resonance spectroscopy in patients with fulminant hepatic failure.
    Journal of gastroenterology and hepatology, 2008, Volume: 23, Issue:7 Pt 2

    Topics: Adolescent; Adult; Anisotropy; Aspartic Acid; Biomarkers; Case-Control Studies; Cerebrovascular Circ

2008
In vivo 1H magnetic resonance spectroscopy-derived metabolite variations between acute-on-chronic liver failure and acute liver failure.
    Liver international : official journal of the International Association for the Study of the Liver, 2008, Volume: 28, Issue:8

    Topics: Adolescent; Adult; Aged; Aspartic Acid; Brain; Case-Control Studies; Choline; Chronic Disease; Creat

2008
Three methods of calibration in quantitative proton MR spectroscopy.
    Journal of magnetic resonance. Series B, 1995, Volume: 106, Issue:3

    Topics: Adult; Aspartic Acid; Body Water; Brain; Brain Chemistry; Brain Injuries; Calibration; Choline; Crea

1995
[Clinical uses of proton magnetic resonance spectroscopy of the brain].
    RoFo : Fortschritte auf dem Gebiete der Rontgenstrahlen und der Nuklearmedizin, 1998, Volume: 168, Issue:6

    Topics: AIDS Dementia Complex; Alzheimer Disease; Animals; Aspartic Acid; Brain; Brain Diseases; Brain Disea

1998
Proton MR spectroscopic measurement of neurometabolites in hepatic encephalopathy during oral lactulose therapy.
    AJNR. American journal of neuroradiology, 1998, Volume: 19, Issue:9

    Topics: Administration, Oral; Adult; Brain; Choline; Creatine; Glutamic Acid; Glutamine; Hepatic Encephalopa

1998
MR imaging and (1)H spectroscopy of brain metabolites in hepatic encephalopathy: time-course of renormalization after liver transplantation.
    Radiology, 2000, Volume: 216, Issue:3

    Topics: Adult; Basal Ganglia; Choline; Creatine; Energy Metabolism; Female; Glutamic Acid; Glutamine; Hepati

2000
Proton MR spectroscopy of neurometabolites in hepatic encephalopathy during L-ornithine-L-aspartate treatment--results of a pilot study.
    Metabolic brain disease, 2002, Volume: 17, Issue:2

    Topics: Aged; Brain; Creatine; Dipeptides; Female; Glutamic Acid; Glutamine; Hepatic Encephalopathy; Humans;

2002