creatine has been researched along with Glioma in 125 studies
Glioma: Benign and malignant central nervous system neoplasms derived from glial cells (i.e., astrocytes, oligodendrocytes, and ependymocytes). Astrocytes may give rise to astrocytomas (ASTROCYTOMA) or glioblastoma multiforme (see GLIOBLASTOMA). Oligodendrocytes give rise to oligodendrogliomas (OLIGODENDROGLIOMA) and ependymocytes may undergo transformation to become EPENDYMOMA; CHOROID PLEXUS NEOPLASMS; or colloid cysts of the third ventricle. (From Escourolle et al., Manual of Basic Neuropathology, 2nd ed, p21)
| Excerpt | Relevance | Reference |
|---|---|---|
| "We performed serial (1)H-MRSI examinations to assess intratumoral metabolite intensities in 16 patients receiving high-dose oral tamoxifen monotherapy for recurrent malignant glioma (WHO grade III or IV) as part of a phase II clinical trial." | 9.13 | Prospective serial proton MR spectroscopic assessment of response to tamoxifen for recurrent malignant glioma. ( Arnold, DL; Assina, R; Caramanos, Z; Langleben, A; Leblanc, R; Preul, MC; Sankar, T; Villemure, JG, 2008) |
| "This study was designed to evaluate proton magnetic resonance spectroscopy ((1)H-MRS) for monitoring the WHO grade II glioma (low-grade glioma (LGG)) treated with temozolomide (TMZ)." | 7.77 | Predicting the outcome of grade II glioma treated with temozolomide using proton magnetic resonance spectroscopy. ( Abud, L; Capelle, L; Chiras, J; Costalat, R; De Marco, G; Guillevin, R; Habas, C; Hoang-Xuan, K; Menuel, C; Taillibert, S; Vallée, JN, 2011) |
| "PURPOSE Our purpose was to evaluate cerebral glioma grade by using normal side creatine (Cr) as an internal reference in multi-voxel 1H-MR spectroscopy." | 7.74 | Evaluation of cerebral glioma grade by using normal side creatine as an internal reference in multi-voxel 1H-MR spectroscopy. ( Ağildere, AM; Atalay, B; Elhan, AH; Geyik, E; Ozen, O; Yerli, H, 2007) |
| " Considering that brain energy metabolism is possibly altered in MSUD, the objective of this study was to determine creatine kinase (CK) activity, a key enzyme of energy homeostasis, in C6 glioma cells exposed to BCKA." | 7.73 | Creatine and antioxidant treatment prevent the inhibition of creatine kinase activity and the morphological alterations of C6 glioma cells induced by the branched-chain alpha-keto acids accumulating in maple syrup urine disease. ( Funchal, C; Gottfried, C; Jacques-Silva, MC; Pessoa-Pureur, R; Santos, AQ; Schuck, PF; Wajner, M, 2006) |
| "Creatine (Cr) is a major metabolite in the bioenergetic system." | 5.46 | Creatine CEST MRI for Differentiating Gliomas with Different Degrees of Aggressiveness. ( Cai, K; Damen, FC; Hariharan, H; Poptani, H; Reddy, R; Scotti, AM; Tain, RW; Zhou, XJ, 2017) |
| "We performed serial (1)H-MRSI examinations to assess intratumoral metabolite intensities in 16 patients receiving high-dose oral tamoxifen monotherapy for recurrent malignant glioma (WHO grade III or IV) as part of a phase II clinical trial." | 5.13 | Prospective serial proton MR spectroscopic assessment of response to tamoxifen for recurrent malignant glioma. ( Arnold, DL; Assina, R; Caramanos, Z; Langleben, A; Leblanc, R; Preul, MC; Sankar, T; Villemure, JG, 2008) |
| " There are a number of metabolites that can be identified by standard brain proton MRS but only a few of them has a clinical significance in diagnosis of gliomas including N-acetylaspartate, choline, creatine, myo-inositol, lactate, and lipids." | 4.89 | Potential of MR spectroscopy for assessment of glioma grading. ( Bulik, M; Jancalek, R; Mechl, M; Skoch, A; Vanicek, J, 2013) |
| "Age and choline/creatine ratio are strong independent prognostic factors in high grade gliomas." | 3.81 | Prognostic Value of MRS Metabolites in Postoperative Irradiated High Grade Gliomas. ( Kelekis, N; Kokakis, I; Kouloulias, V; Kouvaris, JR; Kyrgias, G; Mosa, E; Papathanasiou, M; Pissakas, G; Pistevou-Gombaki, K; Tolia, M; Tsoukalas, N; Verganelakis, D, 2015) |
| "There is significant elevation of the choline (Cho) /creatine (Cr) ratio, Cho peak and depression of the N-acetylaspartate (NAA) peak in gliomas." | 3.78 | Preoperative assessment using multimodal functional magnetic resonance imaging techniques in patients with brain gliomas. ( Shang, HB; Zhang, WF; Zhao, WG, 2012) |
| "This study was designed to evaluate proton magnetic resonance spectroscopy ((1)H-MRS) for monitoring the WHO grade II glioma (low-grade glioma (LGG)) treated with temozolomide (TMZ)." | 3.77 | Predicting the outcome of grade II glioma treated with temozolomide using proton magnetic resonance spectroscopy. ( Abud, L; Capelle, L; Chiras, J; Costalat, R; De Marco, G; Guillevin, R; Habas, C; Hoang-Xuan, K; Menuel, C; Taillibert, S; Vallée, JN, 2011) |
| "Our purpose was to investigate whether in vivo proton magnetic resonance spectroscopic imaging, using normalized concentrations of total choline (tCho) and total creatine (tCr), can differentiate between WHO grade I pilocytic astrocytoma (PA) and diffuse, fibrillary WHO grade II astrocytoma (DA) in children." | 3.76 | Proton magnetic resonance spectroscopic imaging in pediatric low-grade gliomas. ( Franz, K; Hattingen, E; Kieslich, M; Lehrbecher, T; Pilatus, U; Porto, L, 2010) |
| "PURPOSE Our purpose was to evaluate cerebral glioma grade by using normal side creatine (Cr) as an internal reference in multi-voxel 1H-MR spectroscopy." | 3.74 | Evaluation of cerebral glioma grade by using normal side creatine as an internal reference in multi-voxel 1H-MR spectroscopy. ( Ağildere, AM; Atalay, B; Elhan, AH; Geyik, E; Ozen, O; Yerli, H, 2007) |
| "In vivo magnetic resonance spectroscopy (MRS) studies of glial brain tumours reported that higher grade of astrocytoma is associated with increased level of choline-containing compounds (Cho) and decreased levels of N-acetylaspartate (NAA) and creatine and phosphocreatine (Cr)." | 3.73 | In vitro study of astrocytic tumour metabolism by proton magnetic resonance spectroscopy. ( Belan, V; Béres, A; De Riggo, J; Dobrota, D; Galanda, M; Likavcanová, K; Liptaj, T; Mlynárik, V; Prónayová, N, 2005) |
| " Considering that brain energy metabolism is possibly altered in MSUD, the objective of this study was to determine creatine kinase (CK) activity, a key enzyme of energy homeostasis, in C6 glioma cells exposed to BCKA." | 3.73 | Creatine and antioxidant treatment prevent the inhibition of creatine kinase activity and the morphological alterations of C6 glioma cells induced by the branched-chain alpha-keto acids accumulating in maple syrup urine disease. ( Funchal, C; Gottfried, C; Jacques-Silva, MC; Pessoa-Pureur, R; Santos, AQ; Schuck, PF; Wajner, M, 2006) |
| "Diffusion tensor imaging (DTI) and MR spectroscopy are noninvasive, quantitative tools for the preoperative assessment of gliomas with which the quantitative parameter fractional anisotropy (FA) and the concentration of neurometabolites N-acetylaspartate (NAA), choline (Cho), creatine (Cr) of the brain can be determined." | 3.73 | Disarrangement of fiber tracts and decline of neuronal density correlate in glioma patients--a combined diffusion tensor imaging and 1H-MR spectroscopy study. ( Ding, XQ; Fiehler, J; Goebell, E; Hagel, C; Heese, O; Kucinski, T; Nietz, S; Paustenbach, S; Westphal, M; Zeumer, H, 2006) |
| " The concentration of taurine (Tau) in medulloblastomas was 29." | 3.72 | In vivo quantification of the metabolites in normal brain and brain tumors by proton MR spectroscopy using water as an internal standard. ( Harada, K; Houkin, K; Tong, Z; Yamaki, T, 2004) |
| " MRS of normal brain parenchyma displays 4 main metabolites: N-acetyl aspartate (neuronal marker), creatine (cellular density marker), choline (membrane activity marker) and myoinositol (glial marker); pathological processes lead to variations of the level of these metabolites and/or the appearance of abnormal metabolites (lactate), following different patterns according to pathological process involved: glioma, meningioma, metastasis, bacterial or toxoplasmic abscess, radionecrosis." | 3.71 | [Contribution of magnetic resonance spectrometry to the diagnosis of intracranial tumors]. ( Confort-Gouny, S; Cozzone, PJ; Dufour, H; Galanaud, D; Le Fur, Y; Nicoli, F; Peragut, JC; Ranjeva, JP; Roche, P; Viout, P, 2002) |
| " Non-neoplastic lesions such as cerebral infarctions and brain abscesses are marked by decreases in choline (Cho), creatine (Cr) and N-acetyl-aspartate (NAA), while tumours generally have elevated Cho and decreased levels of Cr and NAA." | 3.71 | Clinical application of proton magnetic resonance spectroscopy in the diagnosis of intracranial mass lesions. ( Herminghaus, S; Krings, T; Lanfermann, H; Marquardt, G; Möller-Hartmann, W; Pilatus, U; Zanella, FE, 2002) |
| " Spectroscopy is a reliable technique for grading of gliomas when N-acetyl-aspartate/choline and choline/creatine ratios and presence of lipids are used in combination." | 3.69 | Characterization of intracranial mass lesions with in vivo proton MR spectroscopy. ( Chhabra, DK; Gupta, RK; Jain, VK; Pandey, R; Poptani, H; Roy, R, 1995) |
| " The NAA (N-acetylaspartate)/Cho (choline) ratio of Grade 2 astrocytoma was higher than that of Grade 4." | 3.69 | Non-invasive characterization of brain tumor by in-vivo proton magnetic resonance spectroscopy. ( Bandou, K; Harada, M; Kannuki, S; Miyoshi, H; Nishitani, H; Tanouchi, M, 1995) |
| "(a) Hamartomas showed higher N-acetyl aspartate/creatine, creatine/choline, and N-acetyl aspartate/choline ratios than gliomas." | 3.69 | Proton MR spectroscopy in patients with neurofibromatosis type 1: evaluation of hamartomas and clinical correlation. ( Castillo, M; Green, C; Greenwood, R; Kwock, L; Schiro, S; Smith, K; Wilson, D, 1995) |
| " We used proton nuclear magnetic resonance spectroscopy to detect the presence of simple metabolites (such as lactic acid, creatine/phosphocreatine, N-acetyl aspartate, and the "choline" pool) in extracts of a human glioma grown subcutaneously in athymic ("nu/nu") mice." | 3.69 | Effects of therapy on the 1H NMR spectrum of a human glioma line. ( Cazzaniga, S; Charles, HC; Schold, SC; Sostman, HD, 1994) |
| "There were no significant adverse effects from FLT injected at a dose of 0." | 2.73 | NCI-sponsored trial for the evaluation of safety and preliminary efficacy of FLT as a marker of proliferation in patients with recurrent gliomas: safety studies. ( Eary, JF; Hoffman, JM; Krohn, KA; Link, JM; Muzi, M; Spence, AM, 2008) |
| "Creatine (Cr) is a major metabolite in the bioenergetic system." | 1.46 | Creatine CEST MRI for Differentiating Gliomas with Different Degrees of Aggressiveness. ( Cai, K; Damen, FC; Hariharan, H; Poptani, H; Reddy, R; Scotti, AM; Tain, RW; Zhou, XJ, 2017) |
| "Glioma is one of the most common types of brain tumors." | 1.46 | Assessment of alterations in X-ray irradiation-induced DNA damage of glioma cells by using proton nuclear magnetic resonance spectroscopy. ( Li, F; Li, H; Shi, W; Xu, Y; Yi, C; Zeng, Q, 2017) |
| "Glioma is the most common type of the primary CNS tumor." | 1.43 | Noninvasive evaluation of radiation-enhanced glioma cells invasiveness by ultra-high-field (1)H-MRS in vitro. ( Cui, Y; Li, FY; Li, HX; Shi, WQ; Wang, JZ; Xu, YJ; Zeng, QS, 2016) |
| "Monofocal acute inflammatory demyelination (MAID), which is observable by CT and MRI as a well-enhanced mass lesion with prominent perifocal edema, is very similar to malignant gliomas radiologically, making differential diagnosis of the two pathologies difficult." | 1.37 | Metabolic assessment of monofocal acute inflammatory demyelination using MR spectroscopy and (11)C-methionine-, (11)C-choline-, and (18)F-fluorodeoxyglucose-PET. ( Aki, T; Asano, Y; Ito, T; Iwama, T; Miwa, K; Shinoda, J; Takenaka, S; Yokoyama, K, 2011) |
| "Most of the brain tumors were characterized by strongly reduced total N-acetylaspartyl compounds and marked increases of myo-inositol and choline-containing compounds, consistent with a lack of neuroaxonal tissue and a proliferation of glial cells." | 1.31 | Quantitative proton magnetic resonance spectroscopy of focal brain lesions. ( Dechent, P; Frahm, J; Hanefeld, F; Herms, J; Markakis, E; Maxton, C; Wilken, B, 2000) |
| "High-grade brain tumors are known to have a high rate of glucose (Glc) consumption." | 1.31 | High glycolytic activity in rat glioma demonstrated in vivo by correlation peak 1H magnetic resonance imaging. ( Décorps, M; Rémy, C; von Kienlin , M; Ziegler, A, 2001) |
| "Seventeen brain tumors were measured by 1H-CSI (chemical shift imaging) in a 1." | 1.30 | Evaluation of metabolic heterogeneity in brain tumors using 1H-chemical shift imaging method. ( Furuya, S; Ide, M; Kizu, O; Maeda, T; Morishita, H; Naruse, S; Ueda, S, 1997) |
| "Higher grades of brain tumors in this study were associated with higher Cho/reference and lower NAA/reference values." | 1.29 | Noninvasive evaluation of malignancy of brain tumors with proton MR spectroscopy. ( Arai, N; Fujiwara, S; Hara, K; Kayama, T; Kumabe, T; Ono, Y; Sato, K; Shimizu, H; Tominaga, T; Yoshimoto, T, 1996) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (0.80) | 18.7374 |
| 1990's | 20 (16.00) | 18.2507 |
| 2000's | 53 (42.40) | 29.6817 |
| 2010's | 42 (33.60) | 24.3611 |
| 2020's | 9 (7.20) | 2.80 |
| Authors | Studies |
|---|---|
| Rudnay, M | 1 |
| Waczulikova, I | 1 |
| Bullova, A | 1 |
| Rjaskova, G | 1 |
| Chorvath, M | 1 |
| Jezberova, M | 1 |
| Lehotska, V | 1 |
| Wang, MH | 1 |
| Roa, W | 1 |
| Wachowicz, K | 1 |
| Yahya, A | 1 |
| Murtha, A | 1 |
| Amanie, J | 1 |
| Chainey, J | 1 |
| Quon, H | 1 |
| Ghosh, S | 1 |
| Patel, S | 1 |
| Tran, D | 3 |
| Nguyen, DH | 3 |
| Nguyen, HK | 3 |
| Nguyen-Thanh, VA | 3 |
| Dong-Van, H | 3 |
| Nguyen, MD | 3 |
| De Stefano, FA | 1 |
| Morell, AA | 1 |
| Smith, G | 1 |
| Warner, T | 1 |
| Soldozy, S | 1 |
| Elarjani, T | 1 |
| Eichberg, DG | 1 |
| Luther, E | 1 |
| Komotar, RJ | 1 |
| Qiao, J | 1 |
| Wu, H | 1 |
| Liu, J | 1 |
| Kang, H | 1 |
| Wang, S | 1 |
| Fang, J | 1 |
| Zhang, J | 3 |
| Zhang, W | 1 |
| Goryawala, M | 1 |
| Saraf-Lavi, E | 1 |
| Nagornaya, N | 1 |
| Heros, D | 1 |
| Komotar, R | 1 |
| Maudsley, AA | 1 |
| Fujita, Y | 1 |
| Kohta, M | 1 |
| Sasayama, T | 1 |
| Tanaka, K | 1 |
| Hashiguchi, M | 1 |
| Nagashima, H | 1 |
| Kyotani, K | 1 |
| Nakai, T | 1 |
| Ito, T | 2 |
| Kohmura, E | 1 |
| Wang, AP | 1 |
| Suryavanshi, T | 1 |
| Marcucci, M | 1 |
| Fong, C | 1 |
| Whitton, AC | 1 |
| Reddy, KKV | 1 |
| Alirezaei, Z | 1 |
| Amouheidari, A | 1 |
| Hassanpour, M | 1 |
| Davanian, F | 1 |
| Iraji, S | 1 |
| Shokrani, P | 1 |
| Nazem-Zadeh, MR | 1 |
| Ditter, P | 1 |
| Hattingen, E | 7 |
| Liu, Z | 1 |
| Berrington, A | 1 |
| Voets, NL | 1 |
| Larkin, SJ | 1 |
| de Pennington, N | 1 |
| Mccullagh, J | 1 |
| Stacey, R | 1 |
| Schofield, CJ | 1 |
| Jezzard, P | 1 |
| Clare, S | 1 |
| Cadoux-Hudson, T | 1 |
| Plaha, P | 1 |
| Ansorge, O | 1 |
| Emir, UE | 1 |
| Gao, W | 2 |
| Wang, X | 2 |
| Li, F | 5 |
| Shi, W | 4 |
| Li, H | 4 |
| Zeng, Q | 5 |
| Pedrosa de Barros, N | 1 |
| Meier, R | 1 |
| Pletscher, M | 1 |
| Stettler, S | 1 |
| Knecht, U | 1 |
| Herrmann, E | 1 |
| Schucht, P | 1 |
| Reyes, M | 1 |
| Gralla, J | 1 |
| Wiest, R | 1 |
| Slotboom, J | 1 |
| Cui, Y | 2 |
| Balos, DR | 1 |
| Gavrilović, S | 1 |
| Lavrnić, S | 1 |
| Vasić, B | 1 |
| Macvanski, M | 1 |
| Damjanović, D | 1 |
| Opinćal, TS | 1 |
| Roder, C | 1 |
| Skardelly, M | 1 |
| Ramina, KF | 1 |
| Beschorner, R | 1 |
| Honneger, J | 1 |
| Nägele, T | 1 |
| Tatagiba, MS | 1 |
| Ernemann, U | 1 |
| Bisdas, S | 1 |
| Bradac, O | 1 |
| Vrana, J | 1 |
| Jiru, F | 1 |
| Kramar, F | 1 |
| Netuka, D | 1 |
| Hrabal, P | 1 |
| Horinek, D | 1 |
| de Lacy, P | 1 |
| Benes, V | 1 |
| Madan, A | 1 |
| Ganji, SK | 2 |
| An, Z | 1 |
| Choe, KS | 1 |
| Pinho, MC | 1 |
| Bachoo, RM | 2 |
| Maher, EM | 1 |
| Choi, C | 2 |
| Babourina-Brooks, B | 1 |
| Wilson, M | 1 |
| Arvanitis, TN | 1 |
| Peet, AC | 1 |
| Davies, NP | 1 |
| Stadler, KL | 1 |
| Ober, CP | 1 |
| Feeney, DA | 1 |
| Jessen, CR | 1 |
| Yamamoto, T | 1 |
| Isobe, T | 1 |
| Akutsu, H | 1 |
| Masumoto, T | 1 |
| Ando, H | 1 |
| Sato, E | 1 |
| Takada, K | 1 |
| Anno, I | 1 |
| Matsumura, A | 1 |
| Ranjith, G | 1 |
| Parvathy, R | 1 |
| Vikas, V | 1 |
| Chandrasekharan, K | 1 |
| Nair, S | 1 |
| Ghasemi, K | 1 |
| Khanmohammadi, M | 1 |
| Saligheh Rad, H | 1 |
| Tolia, M | 1 |
| Verganelakis, D | 1 |
| Tsoukalas, N | 1 |
| Kyrgias, G | 1 |
| Papathanasiou, M | 1 |
| Mosa, E | 1 |
| Kokakis, I | 1 |
| Kouvaris, JR | 1 |
| Pissakas, G | 1 |
| Pistevou-Gombaki, K | 1 |
| Kelekis, N | 1 |
| Kouloulias, V | 1 |
| Wang, Q | 1 |
| Zhang, H | 1 |
| Wu, C | 1 |
| Zhu, W | 1 |
| Chen, X | 1 |
| Xu, B | 1 |
| Carrera, I | 1 |
| Richter, H | 1 |
| Beckmann, K | 1 |
| Meier, D | 1 |
| Dennler, M | 1 |
| Kircher, PR | 1 |
| Xu, YJ | 1 |
| Li, HX | 1 |
| Shi, WQ | 1 |
| Li, FY | 1 |
| Wang, JZ | 1 |
| Zeng, QS | 2 |
| Cai, K | 1 |
| Tain, RW | 1 |
| Zhou, XJ | 1 |
| Damen, FC | 1 |
| Scotti, AM | 1 |
| Hariharan, H | 1 |
| Poptani, H | 2 |
| Reddy, R | 1 |
| Roldan-Valadez, E | 1 |
| Rios, C | 1 |
| Motola-Kuba, D | 1 |
| Matus-Santos, J | 1 |
| Villa, AR | 1 |
| Moreno-Jimenez, S | 1 |
| Xu, Y | 2 |
| Yi, C | 1 |
| Raab, P | 2 |
| Franz, K | 5 |
| Lanfermann, H | 5 |
| Setzer, M | 1 |
| Gerlach, R | 2 |
| Zanella, FE | 3 |
| Pilatus, U | 7 |
| Spence, AM | 1 |
| Muzi, M | 1 |
| Link, JM | 1 |
| Hoffman, JM | 1 |
| Eary, JF | 1 |
| Krohn, KA | 1 |
| Sankar, T | 1 |
| Caramanos, Z | 1 |
| Assina, R | 1 |
| Villemure, JG | 1 |
| Leblanc, R | 1 |
| Langleben, A | 1 |
| Arnold, DL | 2 |
| Preul, MC | 1 |
| Li, Y | 1 |
| Srinivasan, R | 1 |
| Ratiney, H | 1 |
| Lu, Y | 2 |
| Chang, SM | 2 |
| Nelson, SJ | 4 |
| Douis, H | 1 |
| Jafri, M | 1 |
| Sherlala, K | 1 |
| Delic, O | 1 |
| Blamek, S | 1 |
| Larysz, D | 1 |
| Ficek, K | 1 |
| Sokół, M | 2 |
| Miszczyk, L | 1 |
| Tarnawski, R | 1 |
| Senft, C | 1 |
| Schänzer, A | 1 |
| Seifert, V | 1 |
| Gasser, T | 1 |
| Matsusue, E | 1 |
| Fink, JR | 1 |
| Rockhill, JK | 1 |
| Ogawa, T | 1 |
| Maravilla, KR | 1 |
| Goenka, AH | 1 |
| Kumar, A | 1 |
| Sharma, R | 1 |
| Server, A | 2 |
| Josefsen, R | 2 |
| Kulle, B | 2 |
| Maehlen, J | 1 |
| Schellhorn, T | 1 |
| Gadmar, Ø | 1 |
| Kumar, T | 2 |
| Haakonsen, M | 1 |
| Langberg, CW | 1 |
| Nakstad, PH | 2 |
| Gadmar, ØB | 1 |
| Liu, H | 2 |
| Zhang, K | 2 |
| Li, C | 1 |
| Zhou, G | 1 |
| Widhalm, G | 1 |
| Krssak, M | 1 |
| Minchev, G | 1 |
| Wöhrer, A | 1 |
| Traub-Weidinger, T | 1 |
| Czech, T | 1 |
| Asenbaum, S | 1 |
| Marosi, C | 1 |
| Knosp, E | 1 |
| Hainfellner, JA | 1 |
| Prayer, D | 1 |
| Wolfsberger, S | 1 |
| Porto, L | 2 |
| Kieslich, M | 2 |
| Lehrbecher, T | 1 |
| Wagner, M | 1 |
| Nafe, R | 1 |
| Jurcoane, A | 1 |
| Rieger, J | 1 |
| Steinbach, JP | 1 |
| Takenaka, S | 1 |
| Shinoda, J | 1 |
| Asano, Y | 1 |
| Aki, T | 1 |
| Miwa, K | 1 |
| Yokoyama, K | 1 |
| Iwama, T | 1 |
| Guillevin, R | 1 |
| Menuel, C | 1 |
| Taillibert, S | 1 |
| Capelle, L | 1 |
| Costalat, R | 1 |
| Abud, L | 1 |
| Habas, C | 1 |
| De Marco, G | 1 |
| Hoang-Xuan, K | 1 |
| Chiras, J | 1 |
| Vallée, JN | 1 |
| Amin, A | 1 |
| Moustafa, H | 1 |
| Ahmed, E | 1 |
| El-Toukhy, M | 1 |
| DeBerardinis, RJ | 1 |
| Hatanpaa, KJ | 1 |
| Rakheja, D | 1 |
| Kovacs, Z | 1 |
| Yang, XL | 1 |
| Mashimo, T | 1 |
| Raisanen, JM | 1 |
| Marin-Valencia, I | 1 |
| Pascual, JM | 1 |
| Madden, CJ | 1 |
| Mickey, BE | 1 |
| Malloy, CR | 1 |
| Maher, EA | 1 |
| Nicolasjilwan, M | 1 |
| Lopes, MB | 1 |
| Larner, J | 1 |
| Wintermark, M | 1 |
| Schiff, D | 1 |
| Steffen-Smith, EA | 1 |
| Venzon, DJ | 1 |
| Bent, RS | 1 |
| Hipp, SJ | 1 |
| Warren, KE | 1 |
| Mertens, K | 1 |
| Acou, M | 1 |
| Van den Broecke, C | 1 |
| Nuyts, R | 1 |
| Van Roost, D | 1 |
| Achten, E | 1 |
| Goethals, I | 1 |
| Shang, HB | 1 |
| Zhao, WG | 1 |
| Zhang, WF | 1 |
| Bulik, M | 1 |
| Jancalek, R | 1 |
| Vanicek, J | 1 |
| Skoch, A | 1 |
| Mechl, M | 1 |
| Caivano, R | 1 |
| Lotumolo, A | 1 |
| Rabasco, P | 1 |
| Zandolino, A | 1 |
| D'Antuono, F | 1 |
| Villonio, A | 1 |
| Lancellotti, MI | 1 |
| Macarini, L | 1 |
| Cammarota, A | 1 |
| Saindane, AM | 1 |
| Cha, S | 4 |
| Law, M | 2 |
| Xue, X | 1 |
| Knopp, EA | 2 |
| Zagzag, D | 1 |
| Rock, JP | 2 |
| Hearshen, D | 2 |
| Scarpace, L | 2 |
| Croteau, D | 2 |
| Gutierrez, J | 2 |
| Fisher, JL | 2 |
| Rosenblum, ML | 1 |
| Mikkelsen, T | 2 |
| Bulakbasi, N | 2 |
| Kocaoglu, M | 2 |
| Ors, F | 1 |
| Tayfun, C | 2 |
| Uçöz, T | 1 |
| Galanaud, D | 1 |
| Nicoli, F | 1 |
| Le Fur, Y | 1 |
| Roche, P | 1 |
| Confort-Gouny, S | 1 |
| Dufour, H | 1 |
| Ranjeva, JP | 1 |
| Peragut, JC | 1 |
| Viout, P | 1 |
| Cozzone, PJ | 1 |
| Simonetti, AW | 1 |
| Melssen, WJ | 1 |
| van der Graaf, M | 1 |
| Postma, GJ | 1 |
| Heerschap, A | 2 |
| Buydens, LM | 1 |
| Lee, MC | 1 |
| Pirzkall, A | 2 |
| McKnight, TR | 4 |
| Ando, K | 1 |
| Ishikura, R | 1 |
| Nagami, Y | 1 |
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| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| NCI-Sponsored Trial for the Evaluation of Safety and Preliminary Efficacy Using [F18] Fluorothymidine (FLT) As a Marker of Proliferation in Patients With Primary Brain Tumors[NCT00276770] | 12 participants (Actual) | Interventional | 2006-02-28 | Completed | |||
| Multi-paramEtric Imaging to Assess Treatment REsponse After Stereotactic Radiosurgery of Brain Metastases[NCT04626206] | 12 participants (Anticipated) | Observational | 2020-12-31 | Not yet recruiting | |||
| Treatment Development of Triheptanoin for Glucose Transporter Type I Deficiency[NCT02021526] | Phase 1/Phase 2 | 0 participants (Actual) | Interventional | 2015-12-31 | Withdrawn (stopped due to NIH funding resulted in new clinical trial) | ||
| Metabolic Characterization of Space Occupying Lesions of the Brain Using in Vivo MR- (Spectroscopic) Imaging at 3 Tesla and 7 Tesla[NCT04233788] | 55 participants (Anticipated) | Observational | 2021-09-01 | Recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
7 reviews available for creatine and Glioma
| Article | Year |
|---|---|
Unique magnetic resonance spectroscopy profile of intracranial meningiomas compared to gliomas: a systematic review.
Topics: Aspartic Acid; Brain Neoplasms; Choline; Creatine; Female; Glioma; Humans; Magnetic Resonance Spectr | 2023 |
The diagnostic performance of magnetic resonance spectroscopy in differentiating high-from low-grade gliomas: A systematic review and meta-analysis.
Topics: Area Under Curve; Aspartic Acid; Brain Neoplasms; Choline; Creatine; Databases, Factual; Glioma; Hum | 2016 |
Potential of MR spectroscopy for assessment of glioma grading.
Topics: Aspartic Acid; Brain Neoplasms; Choline; Creatine; Glioma; Humans; Inositol; Lactates; Lipid Metabol | 2013 |
3 Tesla magnetic resonance spectroscopy: cerebral gliomas vs. metastatic brain tumors. Our experience and review of the literature.
Topics: Adult; Aged; Aged, 80 and over; Aspartic Acid; Brain Neoplasms; Choline; Creatine; Diagnosis, Differ | 2013 |
Proton magnetic resonance spectroscopic evaluation of brain tumor metabolism.
Topics: Alanine; Aspartic Acid; Brain Neoplasms; Choline; Creatine; Glioma; Glutamic Acid; Glutamine; Humans | 2004 |
Brain stem involvement in children with neurofibromatosis type 1: role of magnetic resonance imaging and spectroscopy in the distinction from diffuse pontine glioma.
Topics: Adolescent; Aspartic Acid; Brain Neoplasms; Brain Stem; Child; Child, Preschool; Choline; Creatine; | 1997 |
Anaerobic energy metabolism in brain tumors.
Topics: Adenosine Diphosphate; Adenosine Monophosphate; Adenosine Triphosphate; Aerobiosis; Anaerobiosis; An | 1972 |
8 trials available for creatine and Glioma
| Article | Year |
|---|---|
Evaluation of human glioma using in-vivo proton magnetic resonance spectroscopy combined with expression of cyclooxygenase-2: a preliminary clinical trial.
Topics: Adult; Aged; Biomarkers, Tumor; Brain; Brain Neoplasms; Choline; Creatine; Cyclooxygenase 2; Female; | 2017 |
NCI-sponsored trial for the evaluation of safety and preliminary efficacy of FLT as a marker of proliferation in patients with recurrent gliomas: safety studies.
Topics: Adult; Biomarkers; Carbon Dioxide; Cell Proliferation; Creatine; Dideoxynucleosides; Drug-Related Si | 2008 |
Prospective serial proton MR spectroscopic assessment of response to tamoxifen for recurrent malignant glioma.
Topics: Adult; Aged; Antineoplastic Agents, Hormonal; Aspartic Acid; Brain Neoplasms; Choline; Creatine; Dis | 2008 |
Distinction between high-grade gliomas and solitary metastases using peritumoral 3-T magnetic resonance spectroscopy, diffusion, and perfusion imagings.
Topics: Adult; Aged; Aspartic Acid; Blood Volume; Brain; Brain Neoplasms; Cerebrovascular Circulation; Choli | 2004 |
Contrast/Noise ratio on conventional MRI and choline/creatine ratio on proton MRI spectroscopy accurately discriminate low-grade from high-grade cerebral gliomas.
Topics: Adolescent; Adult; Aged; Algorithms; Brain Neoplasms; Child; Child, Preschool; Choline; Creatine; Fe | 2006 |
Correlation of magnetic resonance spectroscopic and growth characteristics within Grades II and III gliomas.
Topics: Antibodies, Antinuclear; Antibodies, Monoclonal; Apoptosis; Aspartic Acid; Brain Neoplasms; Cell Pro | 2007 |
Multivoxel 3D proton MR spectroscopy in the distinction of recurrent glioma from radiation injury.
Topics: Adult; Aged; Aspartic Acid; Brain; Brain Neoplasms; Choline; Creatine; Diagnosis, Differential; Fema | 2007 |
Proton magnetic resonance spectroscopy in patients with glial tumors: a multicenter study.
Topics: Adolescent; Adult; Aged; Analysis of Variance; Astrocytoma; Brain; Brain Neoplasms; Child; Child, Pr | 1996 |
110 other studies available for creatine and Glioma
| Article | Year |
|---|---|
Magnetic resonance spectroscopy - its added value in brain glioma multiparametric assessment.
Topics: Aspartic Acid; Brain; Brain Neoplasms; Choline; Creatine; Glioma; Humans; Magnetic Resonance Spectro | 2021 |
Early Metabolic Changes in 1H-MRSI Predictive for Survival in Patients With Newly Diagnosed High-grade Glioma.
Topics: Brain Neoplasms; Choline; Creatine; Glioma; Humans; Magnetic Resonance Imaging; Magnetic Resonance S | 2022 |
Diagnostic performance of MRI perfusion and spectroscopy for brainstem glioma grading.
Topics: Aspartic Acid; Brain Neoplasms; Brain Stem; Child; Choline; Creatine; Glioma; Humans; Magnetic Reson | 2022 |
Diagnostic performance of MRI perfusion and spectroscopy for brainstem glioma grading.
Topics: Aspartic Acid; Brain Neoplasms; Brain Stem; Child; Choline; Creatine; Glioma; Humans; Magnetic Reson | 2022 |
Diagnostic performance of MRI perfusion and spectroscopy for brainstem glioma grading.
Topics: Aspartic Acid; Brain Neoplasms; Brain Stem; Child; Choline; Creatine; Glioma; Humans; Magnetic Reson | 2022 |
Diagnostic performance of MRI perfusion and spectroscopy for brainstem glioma grading.
Topics: Aspartic Acid; Brain Neoplasms; Brain Stem; Child; Choline; Creatine; Glioma; Humans; Magnetic Reson | 2022 |
Diagnostic performance of MRI perfusion and spectroscopy for brainstem glioma grading.
Topics: Aspartic Acid; Brain Neoplasms; Brain Stem; Child; Choline; Creatine; Glioma; Humans; Magnetic Reson | 2022 |
Diagnostic performance of MRI perfusion and spectroscopy for brainstem glioma grading.
Topics: Aspartic Acid; Brain Neoplasms; Brain Stem; Child; Choline; Creatine; Glioma; Humans; Magnetic Reson | 2022 |
Diagnostic performance of MRI perfusion and spectroscopy for brainstem glioma grading.
Topics: Aspartic Acid; Brain Neoplasms; Brain Stem; Child; Choline; Creatine; Glioma; Humans; Magnetic Reson | 2022 |
Diagnostic performance of MRI perfusion and spectroscopy for brainstem glioma grading.
Topics: Aspartic Acid; Brain Neoplasms; Brain Stem; Child; Choline; Creatine; Glioma; Humans; Magnetic Reson | 2022 |
Diagnostic performance of MRI perfusion and spectroscopy for brainstem glioma grading.
Topics: Aspartic Acid; Brain Neoplasms; Brain Stem; Child; Choline; Creatine; Glioma; Humans; Magnetic Reson | 2022 |
Spectral Analysis Based on Hemodynamic Habitat Imaging Predicts Isocitrate Dehydrogenase Status and Prognosis in High-Grade Glioma.
Topics: Brain Neoplasms; Creatine; Glioma; Hemodynamics; Humans; Isocitrate Dehydrogenase; Magnetic Resonanc | 2023 |
The Association between Whole-Brain MR Spectroscopy and IDH Mutation Status in Gliomas.
Topics: Adult; Aspartic Acid; Brain; Brain Neoplasms; Choline; Creatine; Female; Glioma; Humans; Isocitrate | 2020 |
Intraoperative 3-T Magnetic Resonance Spectroscopy for Detection of Proliferative Remnants of Glioma.
Topics: Adult; Aged; Aged, 80 and over; Brain; Brain Neoplasms; Choline; Creatine; Female; Glioma; Humans; M | 2020 |
Radiation Necrosis Following Stereotactic Radiosurgery for Trigeminal Neuralgia.
Topics: Aged, 80 and over; Aspartic Acid; Brain Diseases; Brain Neoplasms; Choline; Creatine; Diagnostic Err | 2020 |
Early Detection of Radiation-Induced Injury and Prediction of Cognitive Deficit by MRS Metabolites in Radiotherapy of Low-Grade Glioma.
Topics: Adolescent; Adult; Aspartic Acid; Brain Neoplasms; Cognitive Dysfunction; Creatine; Early Diagnosis; | 2021 |
[Magnetic resonance spectroscopy of brain tumors].
Topics: Aspartic Acid; Brain; Brain Neoplasms; Choline; Creatine; Glioma; Humans; Magnetic Resonance Imaging | 2017 |
Age, choline-to-N-acetyl aspartate, and lipids-lactate-to-creatine ratios assemble a significant Cox's proportional-hazards regression model for survival prediction in patients with high-grade gliomas.
Topics: Aspartic Acid; Brain Neoplasms; Choline; Creatine; Glioma; Humans; Lactic Acid; Lipids; Magnetic Res | 2017 |
A comparison of 2-hydroxyglutarate detection at 3 and 7 T with long-TE semi-LASER.
Topics: Adult; Brain Neoplasms; Choline; Creatine; Female; Glioma; Glutarates; Humans; Isocitrate Dehydrogen | 2018 |
Cho/Cr ratio at MR spectroscopy as a biomarker for cellular proliferation activity and prognosis in glioma: correlation with the expression of minichromosome maintenance protein 2.
Topics: Adolescent; Adult; Aged; Aspartic Acid; Biomarkers; Brain; Brain Neoplasms; Cell Proliferation; Chil | 2019 |
On the relation between MR spectroscopy features and the distance to MRI-visible solid tumor in GBM patients.
Topics: Algorithms; Aspartic Acid; Brain; Brain Neoplasms; Choline; Creatine; Glioma; Healthy Volunteers; Hu | 2018 |
Measuring the lactate-to-creatine ratio via
Topics: Apoptosis; Brain Neoplasms; Cell Cycle Checkpoints; Cell Line, Tumor; Creatine; DNA Damage; Electrop | 2018 |
Proton magnetic resonance spectroscopy and apparent diffusion coefficient in evaluation of solid brain lesions.
Topics: Adolescent; Adult; Aged; Aspartic Acid; Brain; Brain Neoplasms; Child; Choline; Creatine; Diffusion | 2013 |
Spectroscopy imaging in intraoperative MR suite: tissue characterization and optimization of tumor resection.
Topics: Adult; Aged; Aspartic Acid; Brain; Brain Neoplasms; Choline; Creatine; Female; Glioma; Humans; Image | 2014 |
Recognition of anaplastic foci within low-grade gliomas using MR spectroscopy.
Topics: Adult; Aged; Biopsy; Brain Neoplasms; Creatine; Glioma; Humans; Magnetic Resonance Spectroscopy; Mid | 2014 |
Proton T2 measurement and quantification of lactate in brain tumors by MRS at 3 Tesla in vivo.
Topics: Adult; Aged; Artifacts; Aspartic Acid; Brain Chemistry; Brain Neoplasms; Choline; Creatine; Female; | 2015 |
MRS water resonance frequency in childhood brain tumours: a novel potential biomarker of temperature and tumour environment.
Topics: Adolescent; Algorithms; Biomarkers, Tumor; Body Water; Brain Neoplasms; Cerebellar Neoplasms; Child; | 2014 |
Multivoxel proton magnetic resonance spectroscopy of inflammatory and neoplastic lesions of the canine brain at 3.0 T.
Topics: Analysis of Variance; Animals; Aspartic Acid; Brain; Brain Neoplasms; Choline; Creatine; Diagnosis, | 2014 |
Influence of echo time in quantitative proton MR spectroscopy using LCModel.
Topics: Aspartic Acid; Brain; Brain Neoplasms; Choline; Creatine; Glioma; Humans; Image Processing, Computer | 2015 |
Machine learning methods for the classification of gliomas: Initial results using features extracted from MR spectroscopy.
Topics: Algorithms; Artificial Intelligence; Aspartic Acid; Biomarkers, Tumor; Brain Neoplasms; Choline; Cre | 2015 |
Accurate grading of brain gliomas by soft independent modeling of class analogy based on non-negative matrix factorization of proton magnetic resonance spectra.
Topics: Algorithms; Aspartic Acid; Brain Neoplasms; Choline; Creatine; Glioma; Glycine; Humans; Neoplasm Gra | 2016 |
Prognostic Value of MRS Metabolites in Postoperative Irradiated High Grade Gliomas.
Topics: Adult; Age Factors; Aged; Choline; Creatine; Disease-Free Survival; Female; Glioma; Humans; Magnetic | 2015 |
Evaluation of intracranial neoplasia and noninfectious meningoencephalitis in dogs by use of short echo time, single voxel proton magnetic resonance spectroscopy at 3.0 Tesla.
Topics: Animals; Aspartic Acid; Brain Neoplasms; Case-Control Studies; Creatine; Dog Diseases; Dogs; Female; | 2016 |
Noninvasive evaluation of radiation-enhanced glioma cells invasiveness by ultra-high-field (1)H-MRS in vitro.
Topics: Aspartic Acid; Brain Neoplasms; Cell Culture Techniques; Cell Line, Tumor; Cell Survival; Choline; C | 2016 |
Creatine CEST MRI for Differentiating Gliomas with Different Degrees of Aggressiveness.
Topics: Animals; Brain Neoplasms; Cell Differentiation; Creatine; Glioma; Image Processing, Computer-Assiste | 2017 |
Choline-to-N-acetyl aspartate and lipids-lactate-to-creatine ratios together with age assemble a significant Cox's proportional-hazards regression model for prediction of survival in high-grade gliomas.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Aspartic Acid; Biomarkers; Brain Neoplasms; Choline; Cre | 2016 |
Assessment of alterations in X-ray irradiation-induced DNA damage of glioma cells by using proton nuclear magnetic resonance spectroscopy.
Topics: Apoptosis; Astrocytes; Brain Neoplasms; Cell Cycle; Cell Line, Tumor; Cell Survival; Choline; Creati | 2017 |
Prognostic value of choline and creatine in WHO grade II gliomas.
Topics: Adult; Aged; Brain Neoplasms; Choline; Creatine; Disease-Free Survival; Female; Follow-Up Studies; G | 2008 |
Comparison of T(1) and T(2) metabolite relaxation times in glioma and normal brain at 3T.
Topics: Adult; Analysis of Variance; Aspartic Acid; Brain; Brain Neoplasms; Choline; Creatine; Female; Gliom | 2008 |
Bilateral thalamic glioma.
Topics: Aspartic Acid; Brain Neoplasms; Choline; Creatine; Female; Glioma; Humans; Magnetic Resonance Imagin | 2008 |
(1)H MRSI and progression-free survival in patients with WHO grades II and III gliomas.
Topics: Adult; Aged; Brain Neoplasms; Choline; Creatine; Disease Progression; Disease-Free Survival; Female; | 2010 |
MR spectroscopic evaluation of brain tissue damage after treatment for pediatric brain tumors.
Topics: Adolescent; Aspartic Acid; Brain; Brain Neoplasms; Child; Choline; Creatine; Ependymoma; Female; Gli | 2010 |
Diagnostic value of proton magnetic resonance spectroscopy in the noninvasive grading of solid gliomas: comparison of maximum and mean choline values.
Topics: Adult; Brain Neoplasms; Choline; Creatine; Glioma; Humans; Image Processing, Computer-Assisted; Magn | 2009 |
Distinction between glioma progression and post-radiation change by combined physiologic MR imaging.
Topics: Adult; Aspartic Acid; Blood Volume; Brain; Brain Neoplasms; Cerebrovascular Circulation; Choline; Cr | 2010 |
MR spectroscopy for differentiation of recurrent glioma from radiation-induced changes.
Topics: Adolescent; Adult; Aged; Aspartic Acid; Brain Neoplasms; Child; Child, Preschool; Choline; Contrast | 2009 |
Proton magnetic resonance spectroscopy in the distinction of high-grade cerebral gliomas from single metastatic brain tumors.
Topics: Adult; Aged; Aged, 80 and over; Aspartic Acid; Biomarkers; Brain Neoplasms; Choline; Contrast Media; | 2010 |
Measurements of diagnostic examination performance using quantitative apparent diffusion coefficient and proton MR spectroscopic imaging in the preoperative evaluation of tumor grade in cerebral gliomas.
Topics: Area Under Curve; Aspartic Acid; Brain Neoplasms; Choline; Creatine; Diffusion Magnetic Resonance Im | 2011 |
Noninvasive evaluation of cerebral glioma grade by using multivoxel 3D proton MR spectroscopy.
Topics: Adult; Aged; Aspartic Acid; Biomarkers, Tumor; Brain Neoplasms; Choline; Creatine; Female; Glioma; H | 2011 |
Value of 1H-magnetic resonance spectroscopy chemical shift imaging for detection of anaplastic foci in diffusely infiltrating gliomas with non-significant contrast-enhancement.
Topics: Adolescent; Adult; Aged; Aspartic Acid; Brain; Brain Neoplasms; Choline; Creatine; Female; Glioma; H | 2011 |
Proton magnetic resonance spectroscopic imaging in pediatric low-grade gliomas.
Topics: Adolescent; Astrocytoma; Brain; Brain Neoplasms; Child; Child, Preschool; Choline; Creatine; Diagnos | 2010 |
Heterogeneity in malignant gliomas: a magnetic resonance analysis of spatial distribution of metabolite changes and regional blood volume.
Topics: Adult; Aged; Brain Neoplasms; Cerebrovascular Circulation; Choline; Creatine; Female; Glioma; Humans | 2011 |
Metabolic assessment of monofocal acute inflammatory demyelination using MR spectroscopy and (11)C-methionine-, (11)C-choline-, and (18)F-fluorodeoxyglucose-PET.
Topics: Brain Neoplasms; Carbon Radioisotopes; Choline; Creatine; Demyelinating Diseases; Diagnosis, Differe | 2011 |
Predicting the outcome of grade II glioma treated with temozolomide using proton magnetic resonance spectroscopy.
Topics: Adult; Aged; Antineoplastic Agents, Alkylating; Aspartic Acid; Brain Neoplasms; Choline; Creatine; D | 2011 |
Glioma residual or recurrence versus radiation necrosis: accuracy of pentavalent technetium-99m-dimercaptosuccinic acid [Tc-99m (V) DMSA] brain SPECT compared to proton magnetic resonance spectroscopy (1H-MRS): initial results.
Topics: Adolescent; Adult; Aged; Aspartic Acid; Brain Neoplasms; Choline; Creatine; Female; Follow-Up Studie | 2012 |
2-hydroxyglutarate detection by magnetic resonance spectroscopy in IDH-mutated patients with gliomas.
Topics: Algorithms; Aspartic Acid; Brain; Brain Mapping; Brain Neoplasms; Choline; Creatine; Female; Glioma; | 2012 |
2-hydroxyglutarate detection by magnetic resonance spectroscopy in IDH-mutated patients with gliomas.
Topics: Algorithms; Aspartic Acid; Brain; Brain Mapping; Brain Neoplasms; Choline; Creatine; Female; Glioma; | 2012 |
2-hydroxyglutarate detection by magnetic resonance spectroscopy in IDH-mutated patients with gliomas.
Topics: Algorithms; Aspartic Acid; Brain; Brain Mapping; Brain Neoplasms; Choline; Creatine; Female; Glioma; | 2012 |
2-hydroxyglutarate detection by magnetic resonance spectroscopy in IDH-mutated patients with gliomas.
Topics: Algorithms; Aspartic Acid; Brain; Brain Mapping; Brain Neoplasms; Choline; Creatine; Female; Glioma; | 2012 |
Subependymal seeding of low-grade oligodendroglial neoplasms: a case series.
Topics: Adult; Aspartic Acid; Creatine; Disease Progression; Ependyma; Fourth Ventricle; Glioma; Humans; Iso | 2012 |
Single- and multivoxel proton spectroscopy in pediatric patients with diffuse intrinsic pontine glioma.
Topics: Adolescent; Aspartic Acid; Brain Stem Neoplasms; Child; Child, Preschool; Choline; Creatine; Feasibi | 2012 |
Progressive multifocal leukoencephalopathy (PML) mimicking high-grade glioma on delayed F-18 FDG PET imaging.
Topics: Aspartic Acid; Brain Neoplasms; Choline; Creatine; Diffusion Magnetic Resonance Imaging; Fluorodeoxy | 2012 |
Preoperative assessment using multimodal functional magnetic resonance imaging techniques in patients with brain gliomas.
Topics: Adolescent; Adult; Aged; Anisotropy; Aspartic Acid; Brain Neoplasms; Cerebral Cortex; Child; Choline | 2012 |
Proton MR spectroscopy of tumefactive demyelinating lesions.
Topics: Adult; Aspartic Acid; Brain; Brain Neoplasms; Creatine; Demyelinating Diseases; Diagnosis, Different | 2002 |
Correlations between magnetic resonance spectroscopy and image-guided histopathology, with special attention to radiation necrosis.
Topics: Adult; Brain Neoplasms; Choline; Creatine; Diagnosis, Differential; Glioma; Humans; Lactic Acid; Lip | 2002 |
Combination of single-voxel proton MR spectroscopy and apparent diffusion coefficient calculation in the evaluation of common brain tumors.
Topics: Adolescent; Adult; Aged; Alanine; Aspartic Acid; Astrocytoma; Brain; Brain Neoplasms; Choline; Creat | 2003 |
[Contribution of magnetic resonance spectrometry to the diagnosis of intracranial tumors].
Topics: Aspartic Acid; Biomarkers; Brain Abscess; Brain Neoplasms; Choline; Computer Graphics; Creatine; Dia | 2002 |
A chemometric approach for brain tumor classification using magnetic resonance imaging and spectroscopy.
Topics: Aspartic Acid; Brain; Brain Chemistry; Brain Neoplasms; Cerebrospinal Fluid; Choline; Creatine; Disc | 2003 |
1H-MRSI of radiation effects in normal-appearing white matter: dose-dependence and impact on automated spectral classification.
Topics: Aspartic Acid; Brain; Brain Chemistry; Brain Neoplasms; Choline; Creatine; Dose-Response Relationshi | 2004 |
[Usefulness of Cho/Cr ratio in proton MR spectroscopy for differentiating residual/recurrent glioma from non-neoplastic lesions].
Topics: Adolescent; Adult; Aged; Brain Neoplasms; Child; Child, Preschool; Choline; Creatine; Female; Glioma | 2004 |
Proton magnetic resonance spectroscopy-guided biopsy for cerebral glial tumors.
Topics: Adult; Aged; Biopsy; Brain Neoplasms; Choline; Creatine; Female; Glioma; Humans; Ki-67 Antigen; Magn | 2004 |
In vivo quantification of the metabolites in normal brain and brain tumors by proton MR spectroscopy using water as an internal standard.
Topics: Adult; Aged; Aspartic Acid; Body Water; Brain; Brain Neoplasms; Child; Child, Preschool; Choline; Cr | 2004 |
Perfusion magnetic resonance imaging and magnetic resonance spectroscopy of cerebral gliomas showing imperceptible contrast enhancement on conventional magnetic resonance imaging.
Topics: Adult; Blood Volume; Brain; Choline; Creatine; Female; Glioma; Humans; Magnetic Resonance Angiograph | 2004 |
Proton magnetic resonance spectroscopy of brain tumors correlated with pathology.
Topics: Adult; Aged; Aged, 80 and over; Aspartic Acid; Astrocytoma; Brain; Brain Neoplasms; Choline; Creatin | 2005 |
Longitudinal multivoxel MR spectroscopy study of pediatric diffuse brainstem gliomas treated with radiotherapy.
Topics: Aspartic Acid; Brain Stem Neoplasms; Child; Child, Preschool; Choline; Creatine; Disease Progression | 2005 |
The contribution of magnetic resonance spectroscopy and echoplanar perfusion-weighted MRI in the initial assessment of brain tumours.
Topics: Adolescent; Adult; Aged; Astrocytoma; Blood Volume; Brain Neoplasms; Child; Child, Preschool; Cholin | 2005 |
Proton magnetic resonance spectroscopy of normal human brain and glioma: a quantitative in vivo study.
Topics: Adult; Aspartic Acid; Brain; Choline; Creatine; Female; Glioma; Glycine; Humans; Inositol; Magnetic | 2005 |
Multisection 1H magnetic resonance spectroscopic imaging assessment of glioma response to chemotherapy.
Topics: Adult; Antineoplastic Agents; Aspartic Acid; Brain Neoplasms; Choline; Creatine; Disease-Free Surviv | 2006 |
Independent component analysis to proton spectroscopic imaging data of human brain tumours.
Topics: Algorithms; Aspartic Acid; Astrocytoma; Brain Neoplasms; Cell Proliferation; Choline; Creatine; Glio | 2005 |
In vitro study of astrocytic tumour metabolism by proton magnetic resonance spectroscopy.
Topics: Aspartic Acid; Astrocytes; Astrocytoma; Brain; Brain Neoplasms; Choline; Chromium; Creatine; Gliobla | 2005 |
Preoperative grading of gliomas by using metabolite quantification with high-spatial-resolution proton MR spectroscopic imaging.
Topics: Adolescent; Adult; Aspartic Acid; Brain Neoplasms; Case-Control Studies; Choline; Creatine; Female; | 2006 |
Creatine and antioxidant treatment prevent the inhibition of creatine kinase activity and the morphological alterations of C6 glioma cells induced by the branched-chain alpha-keto acids accumulating in maple syrup urine disease.
Topics: Animals; Antioxidants; Cell Line, Tumor; Cell Shape; Creatine; Creatine Kinase; Glioma; Hemiterpenes | 2006 |
Multiparametric 3T MR approach to the assessment of cerebral gliomas: tumor extent and malignancy.
Topics: Adolescent; Adult; Aged; Aspartic Acid; Brain Neoplasms; Choline; Contrast Media; Creatine; Diffusio | 2006 |
3T 1H-MR spectroscopy in grading of cerebral gliomas: comparison of short and intermediate echo time sequences.
Topics: Adult; Aged; Aspartic Acid; Brain Neoplasms; Choline; Creatine; Echo-Planar Imaging; Female; Glioma; | 2006 |
Disarrangement of fiber tracts and decline of neuronal density correlate in glioma patients--a combined diffusion tensor imaging and 1H-MR spectroscopy study.
Topics: Adult; Aged; Anisotropy; Aspartic Acid; Astrocytoma; Brain; Brain Neoplasms; Cell Size; Choline; Cre | 2006 |
Long-term normal-appearing brain tissue monitoring after irradiation using proton magnetic resonance spectroscopy in vivo: statistical analysis of a large group of patients.
Topics: Adult; Aged; Aspartic Acid; Blood-Brain Barrier; Brain; Brain Neoplasms; Choline; Creatine; Female; | 2006 |
Comments and controversies: magnetic resonance spectroscopy and gliomas.
Topics: Aspartic Acid; Brain Neoplasms; Choline; Creatine; Glioma; Humans; Magnetic Resonance Spectroscopy; | 2006 |
Proton magnetic resonance spectroscopy in childhood brainstem lesions.
Topics: Adolescent; Amino Acids; Aspartic Acid; Brain Chemistry; Brain Diseases; Brain Stem; Brain Stem Neop | 2007 |
Use of MR spectroscopy and functional imaging in the treatment planning of gliomas.
Topics: Brain; Brain Neoplasms; Choline; Cranial Irradiation; Creatine; Glioma; Humans; Image Processing, Co | 2007 |
Proton magnetic resonance spectroscopic imaging in the border zone of gliomas: correlation of metabolic and histological changes at low tumor infiltration--initial results.
Topics: Aspartic Acid; Choline; Creatine; Glioma; Humans; Magnetic Resonance Spectroscopy; Neoplasm Invasive | 2007 |
Evaluation of cerebral glioma grade by using normal side creatine as an internal reference in multi-voxel 1H-MR spectroscopy.
Topics: Adult; Aged; Brain Neoplasms; Choline; Creatine; Female; Glioma; Humans; Magnetic Resonance Imaging; | 2007 |
Multimodal MRI in the characterization of glial neoplasms: the combined role of single-voxel MR spectroscopy, diffusion imaging and echo-planar perfusion imaging.
Topics: Adolescent; Adult; Aged; Aspartic Acid; Biopsy; Blood Flow Velocity; Brain; Brain Neoplasms; Choline | 2007 |
Dysembryoplastic neuroepithelial tumors: proton MR spectroscopy, diffusion and perfusion characteristics.
Topics: Adolescent; Adult; Blood Flow Velocity; Choline; Creatine; Diagnosis, Differential; Diffusion Magnet | 2007 |
Monovoxel 1H magnetic resonance spectroscopy in the progression of gliomas.
Topics: Adult; Aged; Aspartic Acid; Brain Neoplasms; Choline; Creatine; Disease Progression; Female; Glioma; | 2007 |
Analysis of metabolic indices in regions of abnormal perfusion in patients with high-grade glioma.
Topics: Adult; Aged; Brain Neoplasms; Creatine; Female; Glioma; Humans; Lactic Acid; Magnetic Resonance Imag | 2007 |
In vivo proton MR spectroscopy of human gliomas: definition of metabolic coordinates for multi-dimensional classification.
Topics: Adult; Aspartic Acid; Astrocytoma; Brain Neoplasms; Choline; Cluster Analysis; Creatine; Discriminan | 1995 |
Characterization of intracranial mass lesions with in vivo proton MR spectroscopy.
Topics: Adolescent; Adult; Aged; Aspartic Acid; Brain; Brain Diseases; Brain Neoplasms; Child; Choline; Crea | 1995 |
Spectral editing with adiabatic pulses.
Topics: Animals; Aspartic Acid; Brain Neoplasms; Carbon Isotopes; Choline; Creatine; Feasibility Studies; Gl | 1995 |
Localised proton spectroscopy and spectroscopic imaging in cerebral gliomas, with comparison to positron emission tomography.
Topics: Aspartic Acid; Brain; Brain Chemistry; Brain Edema; Carbon Radioisotopes; Creatine; Deoxyglucose; Fl | 1995 |
Proton magnetic resonance spectroscopy of astrocytic tumors: an in vitro study.
Topics: Antibodies, Monoclonal; Astrocytoma; Brain Neoplasms; Choline; Creatine; Diagnosis, Differential; Fe | 1993 |
Non-invasive characterization of brain tumor by in-vivo proton magnetic resonance spectroscopy.
Topics: Aspartic Acid; Astrocytoma; Brain Neoplasms; Choline; Creatine; Ependymoma; Glioma; Humans; Magnetic | 1995 |
Proton MR spectroscopy in patients with neurofibromatosis type 1: evaluation of hamartomas and clinical correlation.
Topics: Adolescent; Adult; Aspartic Acid; Astrocytoma; Brain; Brain Diseases; Brain Neoplasms; Cerebellar Di | 1995 |
Effects of therapy on the 1H NMR spectrum of a human glioma line.
Topics: Animals; Aspartic Acid; Brain Neoplasms; Choline; Creatine; Glioma; Lactates; Magnetic Resonance Spe | 1994 |
Quantitative proton spectroscopy and histology of a canine brain tumor model.
Topics: Animals; Aspartic Acid; Brain Neoplasms; Choline; Creatine; Dogs; Glioma; Lactates; Lactic Acid; Mag | 1993 |
Noninvasive evaluation of malignancy of brain tumors with proton MR spectroscopy.
Topics: Adolescent; Adult; Aged; Aspartic Acid; Brain Neoplasms; Choline; Creatine; Energy Metabolism; Femal | 1996 |
Absolute concentrations of metabolites in human brain tumors using in vitro proton magnetic resonance spectroscopy.
Topics: Adenoma; Adolescent; Adult; Aged; Amino Acids; Brain; Brain Neoplasms; Child; Choline; Creatine; Fem | 1997 |
Evaluation of metabolic heterogeneity in brain tumors using 1H-chemical shift imaging method.
Topics: Aspartic Acid; Brain Neoplasms; Choline; Creatine; Evaluation Studies as Topic; Glioma; Humans; Imag | 1997 |
Increased choline signal coinciding with malignant degeneration of cerebral gliomas: a serial proton magnetic resonance spectroscopy imaging study.
Topics: Adult; Aged; Aspartic Acid; Biomarkers, Tumor; Biopsy; Brain Neoplasms; Cell Transformation, Neoplas | 1997 |
Proton (1H) MR spectroscopy for routine diagnostic evaluation of brain lesions.
Topics: Adenocarcinoma; Adolescent; Adult; Aged; Aged, 80 and over; Aspartic Acid; Brain Diseases; Brain Neo | 1997 |
MR spectroscopy of bilateral thalamic gliomas.
Topics: Adult; Brain Chemistry; Brain Neoplasms; Creatine; Glioma; Humans; Magnetic Resonance Imaging; Magne | 1999 |
Quantitative proton magnetic resonance spectroscopy of focal brain lesions.
Topics: Adolescent; Aspartic Acid; Biomarkers, Tumor; Brain; Brain Abscess; Brain Diseases; Brain Neoplasms; | 2000 |
Proton magnetic resonance chemical shift imaging (1H CSI)-directed stereotactic biopsy.
Topics: Adult; Aspartic Acid; Biopsy, Needle; Brain; Brain Neoplasms; Creatine; Diagnosis, Differential; Ene | 2001 |
Malignancy of brain tumors evaluated by proton magnetic resonance spectroscopy (1H-MRS) in vitro.
Topics: Biopsy; Brain; Brain Neoplasms; Creatine; Diagnosis, Differential; Energy Metabolism; Glioma; Humans | 2000 |
High glycolytic activity in rat glioma demonstrated in vivo by correlation peak 1H magnetic resonance imaging.
Topics: Alanine; Animals; Aspartic Acid; Brain Neoplasms; Choline; Creatine; Ethanolamines; Female; Glioma; | 2001 |
Mapping extracellular pH in rat brain gliomas in vivo by 1H magnetic resonance spectroscopic imaging: comparison with maps of metabolites.
Topics: Animals; Aspartic Acid; Brain Neoplasms; Buffers; Choline; Contrast Media; Creatine; Extracellular S | 2001 |
Correlation between magnetic resonance spectroscopy imaging and image-guided biopsies: semiquantitative and qualitative histopathological analyses of patients with untreated glioma.
Topics: Adolescent; Adult; Aged; Aspartic Acid; Brain; Brain Neoplasms; Choline; Creatine; Dominance, Cerebr | 2001 |
Proton magnetic resonance spectroscopy of cerebral glioma after irradiation.
Topics: Brain; Brain Neoplasms; Choline; Creatine; Glioma; Humans; Magnetic Resonance Spectroscopy | 2001 |
High-grade gliomas and solitary metastases: differentiation by using perfusion and proton spectroscopic MR imaging.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Aspartic Acid; Blood Volume; Brain; Brain Chemistry; Bra | 2002 |
Clinical application of proton magnetic resonance spectroscopy in the diagnosis of intracranial mass lesions.
Topics: Aspartic Acid; Brain Abscess; Brain Neoplasms; Cerebral Infarction; Choline; Creatine; Diagnosis, Di | 2002 |
Proton magnetic resonance spectroscopic imaging for metabolic characterization of demyelinating plaques.
Topics: Acute Disease; Adult; Aspartic Acid; Biopsy; Brain Chemistry; Brain Neoplasms; Choline; Creatine; De | 1992 |
Spatially localized in vivo 1H magnetic resonance spectroscopy of an intracerebral rat glioma.
Topics: Animals; Aspartic Acid; Brain; Brain Neoplasms; Creatine; Female; Glioma; Hydrogen; Lactates; Lactic | 1992 |
Detection of metabolic heterogeneity of human intracranial tumors in vivo by 1H NMR spectroscopic imaging.
Topics: Adult; Aspartic Acid; Astrocytoma; Brain; Brain Neoplasms; Creatine; Glioma; Humans; Magnetic Resona | 1990 |