creatine has been researched along with Friedreich Ataxia in 4 studies
Friedreich Ataxia: An autosomal recessive disease, usually of childhood onset, characterized pathologically by degeneration of the spinocerebellar tracts, posterior columns, and to a lesser extent the corticospinal tracts. Clinical manifestations include GAIT ATAXIA, pes cavus, speech impairment, lateral curvature of spine, rhythmic head tremor, kyphoscoliosis, congestive heart failure (secondary to a cardiomyopathy), and lower extremity weakness. Most forms of this condition are associated with a mutation in a gene on chromosome 9, at band q13, which codes for the mitochondrial protein frataxin. (From Adams et al., Principles of Neurology, 6th ed, p1081; N Engl J Med 1996 Oct 17;335(16):1169-75) The severity of Friedreich ataxia associated with expansion of GAA repeats in the first intron of the frataxin gene correlates with the number of trinucleotide repeats. (From Durr et al, N Engl J Med 1996 Oct 17;335(16):1169-75)
| Excerpt | Relevance | Reference |
|---|---|---|
| " Primary outcome measures were mitochondrial ATP production measured as phosphocreatine recovery by 31Phosphorus magnetic resonance spectroscopy, neurological deficits assessed by the international co-operative ataxia rating scale and cardiac hypertrophy in echocardiography." | 5.11 | L-carnitine and creatine in Friedreich's ataxia. A randomized, placebo-controlled crossover trial. ( Abele, M; Colier, WN; Klockgether, T; Kuntz-Hehner, S; Müller, K; Przuntek, H; Schillings, M; Schöls, L; Skipka, G; van Beekvelt, MC; Vorgerd, M; Zange, J, 2005) |
| "Disease severity was assessed by the Friedreich's Ataxia Rating Scale (FARS)." | 1.36 | (1)H MR spectroscopy in Friedreich's ataxia and ataxia with oculomotor apraxia type 2. ( Bushara, KO; Clark, HB; Eberly, LE; Gomez, CM; Gross, M; Hutter, D; Iltis, I; Oz, G, 2010) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (25.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (25.00) | 29.6817 |
| 2010's | 1 (25.00) | 24.3611 |
| 2020's | 1 (25.00) | 2.80 |
| Authors | Studies |
|---|---|
| Schur, GM | 1 |
| Dunn, J | 1 |
| Nguyen, S | 1 |
| Dedio, A | 1 |
| Wade, K | 1 |
| Tamaroff, J | 1 |
| Mitta, N | 1 |
| Wilson, N | 1 |
| Reddy, R | 1 |
| Lynch, DR | 1 |
| McCormack, SE | 1 |
| Iltis, I | 1 |
| Hutter, D | 1 |
| Bushara, KO | 1 |
| Clark, HB | 1 |
| Gross, M | 1 |
| Eberly, LE | 1 |
| Gomez, CM | 1 |
| Oz, G | 1 |
| Schöls, L | 1 |
| Zange, J | 1 |
| Abele, M | 1 |
| Schillings, M | 1 |
| Skipka, G | 1 |
| Kuntz-Hehner, S | 1 |
| van Beekvelt, MC | 1 |
| Colier, WN | 1 |
| Müller, K | 1 |
| Klockgether, T | 1 |
| Przuntek, H | 1 |
| Vorgerd, M | 1 |
| Lemieux, B | 1 |
| Giguère, R | 1 |
| Shapcott, D | 1 |
1 trial available for creatine and Friedreich Ataxia
| Article | Year |
|---|---|
L-carnitine and creatine in Friedreich's ataxia. A randomized, placebo-controlled crossover trial.
Topics: Adenosine Triphosphate; Adolescent; Adult; Cardiomegaly; Carnitine; Child; Creatine; Female; Friedre | 2005 |
3 other studies available for creatine and Friedreich Ataxia
| Article | Year |
|---|---|
In vivo assessment of OXPHOS capacity using 3 T CrCEST MRI in Friedreich's ataxia.
Topics: Adult; Creatine; Friedreich Ataxia; Humans; Iron-Binding Proteins; Magnetic Resonance Imaging; Neuro | 2022 |
(1)H MR spectroscopy in Friedreich's ataxia and ataxia with oculomotor apraxia type 2.
Topics: Adult; Aspartic Acid; Brain Mapping; Creatine; Female; Friedreich Ataxia; Gait Ataxia; Glutamic Acid | 2010 |
Studies on the role of taurine in Friedreich's ataxia.
Topics: Adolescent; Adult; Creatine; Creatinine; Female; Friedreich Ataxia; Humans; Kidney; Male; Muscular D | 1984 |