creatine has been researched along with Epilepsy in 59 studies
Epilepsy: A disorder characterized by recurrent episodes of paroxysmal brain dysfunction due to a sudden, disorderly, and excessive neuronal discharge. Epilepsy classification systems are generally based upon: (1) clinical features of the seizure episodes (e.g., motor seizure), (2) etiology (e.g., post-traumatic), (3) anatomic site of seizure origin (e.g., frontal lobe seizure), (4) tendency to spread to other structures in the brain, and (5) temporal patterns (e.g., nocturnal epilepsy). (From Adams et al., Principles of Neurology, 6th ed, p313)
| Excerpt | Relevance | Reference |
|---|---|---|
| "The ratios of glutamate (Glu) and glutamate + glutamine (Glx) to total creatine (Glu/tCr and Glx/tCr) in the tumor were associated with epilepsy history." | 8.12 | Glutamic Acid and Total Creatine as Predictive Markers for Epilepsy in Glioblastoma by Using Magnetic Resonance Spectroscopy Before Surgery. ( Fujita, Y; Hashiguchi, M; Kohmura, E; Kohta, M; Maeyama, M; Nagashima, H; Nakai, T; Sasayama, T; Somiya, Y; Tanaka, H; Tanaka, K; Uozumi, Y, 2022) |
| "This article reports the clinical and genetic features of two cases of cerebral creatine deficiency syndrome I (CCDSI) caused by SLC6A8 gene mutations." | 7.96 | [Clinical features and SLC6A8 gene mutations of cerebral creatine deficiency syndrome I: an analysis of two families]. ( Dong, XR; Sun, WH; Wang, HJ; Wang, Y; Wu, BB; Wu, MY; Xiao, FF; Zhang, P; Zhou, WH; Zhuang, DY, 2020) |
| "Proton magnetic resonance spectroscopy analysis showed that the ratio of glutamate/glutamine to creatine (Glx/Cr) in the right hippocampus was significantly increased in patients with moderate depression and correlated positively with HAMD scores." | 7.79 | Increased ratio of glutamate/glutamine to creatine in the right hippocampus contributes to depressive symptoms in patients with epilepsy. ( Chen, CZ; Cheng, WZ; Ding, J; Fan, W; Li, X; Liang, L; Mao, LY; Peng, WF; Wang, X, 2013) |
| " We, therefore, utilized these methods to assess changes in glucose metabolism and metabolites in the rat lithium-pilocarpine model of epilepsy as markers of epileptogenesis from baseline to chronic spontaneous recurrent seizures (SRS)." | 7.78 | Changes in glucose metabolism and metabolites during the epileptogenic process in the lithium-pilocarpine model of epilepsy. ( Chung, JH; Im, KC; Kang, JK; Kim, JS; Kim, KS; Kim, ST; Kim, YI; Lee, EM; Park, GY; Shon, YM; Woo, CW, 2012) |
| "In order to confirm the roles of creatine (Cr) in epilepsy, we investigated the anti-convulsive effects of Cr, creatine transporter (CRT) and creatine kinases (CKs) against chemical-induced acute seizure activity and chronic epileptic seizure activity." | 7.76 | Effects of creatine and β-guanidinopropionic acid and alterations in creatine transporter and creatine kinases expression in acute seizure and chronic epilepsy models. ( Choi, SY; Kang, TC; Kim, DW; Kim, JE; Kwon, OS; Ryu, HJ; Song, HK; Yeo, SI, 2010) |
| "Disorders of creatine synthesis or its transporter resulting in neurological impairment with mental retardation and epilepsy have only been recognized in recent years." | 7.74 | Severe epilepsy in X-linked creatine transporter defect (CRTR-D). ( Baglietto, MG; Battaglia, FM; Caruso, U; Gaggero, R; Jakobs, C; Mancardi, MM; Rossi, A; Salomons, GS; Schiaffino, MC; Veneselli, E; Zara, F, 2007) |
| "Vigabatrin (VGB) is a new antiepileptic drug that increases the human brain gamma-aminobutyric acid (GABA) level by irreversibly inhibiting GABA transaminase." | 6.70 | Effects of vigabatrin on brain GABA+/CR signals in patients with epilepsy monitored by 1H-NMR-spectroscopy: responder characteristics. ( Boesiger, P; Duc, CO; Meier, D; Mueller, SG; Russ, W; Weber, B; Weber, OM; Wieser, HG, 2001) |
| "Epilepsy is one of the main symptoms in GAMT and CT1 deficiency, whereas the occurrence of febrile convulsions in infancy is a relatively common presenting symptom in all the three above-mentioned diseases." | 6.49 | Inborn errors of creatine metabolism and epilepsy. ( Battini, R; Cioni, G; Leuzzi, V; Mastrangelo, M, 2013) |
| "Epilepsy is often considered to be a progressive neurological disease, and the nature of this progression remains unclear." | 5.72 | Insights into the development of pentylenetetrazole-induced epileptic seizures from dynamic metabolomic changes. ( Cheng, P; Jia, P; Liao, S; Meng, K; Xiao, C; Xu, R; Zhao, X; Zheng, X, 2022) |
| "Although epilepsy was not affected by orally administered creatine (400 to 500 mg/kg per day), this treatment resulted in clinical improvement and an increase of creatine in cerebrospinal fluid and brain tissue." | 5.30 | Creatine deficiency syndrome caused by guanidinoacetate methyltransferase deficiency: diagnostic tools for a new inborn error of metabolism. ( Bachert, P; Bremer, HJ; De Deyn, PP; Hess, T; Knopp, MV; Marescau, B; Mayatepek, E; Rating, D; Schulze, A; Wevers, R, 1997) |
| "The ratios of glutamate (Glu) and glutamate + glutamine (Glx) to total creatine (Glu/tCr and Glx/tCr) in the tumor were associated with epilepsy history." | 4.12 | Glutamic Acid and Total Creatine as Predictive Markers for Epilepsy in Glioblastoma by Using Magnetic Resonance Spectroscopy Before Surgery. ( Fujita, Y; Hashiguchi, M; Kohmura, E; Kohta, M; Maeyama, M; Nagashima, H; Nakai, T; Sasayama, T; Somiya, Y; Tanaka, H; Tanaka, K; Uozumi, Y, 2022) |
| "This article reports the clinical and genetic features of two cases of cerebral creatine deficiency syndrome I (CCDSI) caused by SLC6A8 gene mutations." | 3.96 | [Clinical features and SLC6A8 gene mutations of cerebral creatine deficiency syndrome I: an analysis of two families]. ( Dong, XR; Sun, WH; Wang, HJ; Wang, Y; Wu, BB; Wu, MY; Xiao, FF; Zhang, P; Zhou, WH; Zhuang, DY, 2020) |
| "Creatine Transporter Deficiency (CTD) is an inborn error of metabolism presenting with intellectual disability, behavioral disturbances and epilepsy." | 3.96 | Cyclocreatine treatment ameliorates the cognitive, autistic and epileptic phenotype in a mouse model of Creatine Transporter Deficiency. ( Alessandrì, MG; Baroncelli, L; Battini, R; Butt, M; Cacciante, F; Cerri, E; Cioni, G; Do, MT; Gennaro, M; Lupori, L; Mazziotti, R; McKew, JC; Pizzorusso, T; Putignano, E; Sagona, G, 2020) |
| "Proton magnetic resonance spectroscopy analysis showed that the ratio of glutamate/glutamine to creatine (Glx/Cr) in the right hippocampus was significantly increased in patients with moderate depression and correlated positively with HAMD scores." | 3.79 | Increased ratio of glutamate/glutamine to creatine in the right hippocampus contributes to depressive symptoms in patients with epilepsy. ( Chen, CZ; Cheng, WZ; Ding, J; Fan, W; Li, X; Liang, L; Mao, LY; Peng, WF; Wang, X, 2013) |
| " We, therefore, utilized these methods to assess changes in glucose metabolism and metabolites in the rat lithium-pilocarpine model of epilepsy as markers of epileptogenesis from baseline to chronic spontaneous recurrent seizures (SRS)." | 3.78 | Changes in glucose metabolism and metabolites during the epileptogenic process in the lithium-pilocarpine model of epilepsy. ( Chung, JH; Im, KC; Kang, JK; Kim, JS; Kim, KS; Kim, ST; Kim, YI; Lee, EM; Park, GY; Shon, YM; Woo, CW, 2012) |
| "Metabolite maps of N-acetyl aspartate, choline and creatine were generated using (1)H-CSI data from the brain of healthy volunteers and patients with tumor and epilepsy." | 3.76 | Grid-free interactive and automated data processing for MR chemical shift imaging data. ( Confort-Gouny, S; Cozzone, PJ; Guye, M; Kober, F; Le Fur, Y; Nicoli, F, 2010) |
| "In order to confirm the roles of creatine (Cr) in epilepsy, we investigated the anti-convulsive effects of Cr, creatine transporter (CRT) and creatine kinases (CKs) against chemical-induced acute seizure activity and chronic epileptic seizure activity." | 3.76 | Effects of creatine and β-guanidinopropionic acid and alterations in creatine transporter and creatine kinases expression in acute seizure and chronic epilepsy models. ( Choi, SY; Kang, TC; Kim, DW; Kim, JE; Kwon, OS; Ryu, HJ; Song, HK; Yeo, SI, 2010) |
| "Disorders of creatine synthesis or its transporter resulting in neurological impairment with mental retardation and epilepsy have only been recognized in recent years." | 3.74 | Severe epilepsy in X-linked creatine transporter defect (CRTR-D). ( Baglietto, MG; Battaglia, FM; Caruso, U; Gaggero, R; Jakobs, C; Mancardi, MM; Rossi, A; Salomons, GS; Schiaffino, MC; Veneselli, E; Zara, F, 2007) |
| "Vigabatrin (VGB) is a new antiepileptic drug that increases the human brain gamma-aminobutyric acid (GABA) level by irreversibly inhibiting GABA transaminase." | 2.70 | Effects of vigabatrin on brain GABA+/CR signals in patients with epilepsy monitored by 1H-NMR-spectroscopy: responder characteristics. ( Boesiger, P; Duc, CO; Meier, D; Mueller, SG; Russ, W; Weber, B; Weber, OM; Wieser, HG, 2001) |
| "Levetiracetam was generally well tolerated." | 2.70 | Pharmacokinetic study of levetiracetam in children. ( Bebin, EM; Coupez, RM; Fountain, NB; Glauser, TA; Pellock, JM; Ritter, FJ; Shields, WD, 2001) |
| "Epilepsy is one of the main symptoms in GAMT and CT1 deficiency, whereas the occurrence of febrile convulsions in infancy is a relatively common presenting symptom in all the three above-mentioned diseases." | 2.49 | Inborn errors of creatine metabolism and epilepsy. ( Battini, R; Cioni, G; Leuzzi, V; Mastrangelo, M, 2013) |
| "Epilepsy is often considered to be a progressive neurological disease, and the nature of this progression remains unclear." | 1.72 | Insights into the development of pentylenetetrazole-induced epileptic seizures from dynamic metabolomic changes. ( Cheng, P; Jia, P; Liao, S; Meng, K; Xiao, C; Xu, R; Zhao, X; Zheng, X, 2022) |
| "Semiology, seizure frequency, and therapy were assessed for all patients." | 1.46 | Proton MR Spectroscopy in Patients With Sleep-Related Hypermotor Epilepsy (SHE): Evidence of Altered Cingulate Cortex Metabolism. ( Bisulli, F; Ferri, L; Gramegna, LL; Licchetta, L; Lodi, R; Naldi, I; Rizzo, G; Testa, C; Tinuper, P; Tonon, C, 2017) |
| "We present a case of infantile onset Krabbe disease with prolonged survival, initial intracranial optic nerves and optic chiasm hypertrophy, and serial changes on cranial magnetic resonance imaging and magnetic resonance spectroscopy." | 1.38 | Prolonged survival and serial magnetic resonance imaging/magnetic resonance spectroscopy changes in infantile Krabbe disease. ( Bunge, M; Mhanni, AA; Ryner, L; Salman, MS; Udow, S, 2012) |
| "Treatment with creatine monohydrate, to enhance cerebral creatine transport, combined with L-arginine and L-glycine, to enhance cerebral creatine synthesis, resulted in complete resolution of seizures." | 1.36 | Treatment of intractable epilepsy in a female with SLC6A8 deficiency. ( Casey, B; Connolly, MB; Davis, C; Horvath, GA; Jakobs, C; Lowry, N; Mercimek-Mahmutoglu, S; Poskitt, KJ; Salomons, GS; Sinclair, G; Stockler-Ipsiroglu, S, 2010) |
| "Intracranial arachnoid cysts (ACs) are usually asymptomatic, benign developmental anomalies." | 1.35 | Single-voxel magnetic resonance spectroscopy of brain tissue adjacent to arachnoid cysts of epileptic patients. ( Ozcan, C; Ozisik, HI; Sarac, K, 2008) |
| "These data argue that within the seizure onset zone, the tight correlation between total power and NAA/Cr suggests that total electrical output is powered by available mitochondrial function." | 1.35 | Intracranial EEG power and metabolism in human epilepsy. ( Hetherington, HP; Pan, JW; Spencer, DD; Spencer, SS; Zaveri, HP, 2009) |
| "Although epilepsy was not affected by orally administered creatine (400 to 500 mg/kg per day), this treatment resulted in clinical improvement and an increase of creatine in cerebrospinal fluid and brain tissue." | 1.30 | Creatine deficiency syndrome caused by guanidinoacetate methyltransferase deficiency: diagnostic tools for a new inborn error of metabolism. ( Bachert, P; Bremer, HJ; De Deyn, PP; Hess, T; Knopp, MV; Marescau, B; Mayatepek, E; Rating, D; Schulze, A; Wevers, R, 1997) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (3.39) | 18.7374 |
| 1990's | 5 (8.47) | 18.2507 |
| 2000's | 26 (44.07) | 29.6817 |
| 2010's | 22 (37.29) | 24.3611 |
| 2020's | 4 (6.78) | 2.80 |
| Authors | Studies |
|---|---|
| Hashiguchi, M | 1 |
| Tanaka, K | 1 |
| Nagashima, H | 1 |
| Fujita, Y | 1 |
| Tanaka, H | 1 |
| Kohta, M | 1 |
| Nakai, T | 1 |
| Uozumi, Y | 1 |
| Maeyama, M | 1 |
| Somiya, Y | 1 |
| Kohmura, E | 1 |
| Sasayama, T | 1 |
| Zhao, X | 1 |
| Cheng, P | 1 |
| Xu, R | 1 |
| Meng, K | 1 |
| Liao, S | 1 |
| Jia, P | 1 |
| Zheng, X | 1 |
| Xiao, C | 1 |
| Sun, WH | 1 |
| Zhuang, DY | 1 |
| Wang, Y | 1 |
| Xiao, FF | 1 |
| Wu, MY | 1 |
| Dong, XR | 1 |
| Zhang, P | 1 |
| Wang, HJ | 1 |
| Zhou, WH | 1 |
| Wu, BB | 1 |
| Cacciante, F | 1 |
| Gennaro, M | 1 |
| Sagona, G | 1 |
| Mazziotti, R | 1 |
| Lupori, L | 1 |
| Cerri, E | 1 |
| Putignano, E | 1 |
| Butt, M | 1 |
| Do, MT | 1 |
| McKew, JC | 1 |
| Alessandrì, MG | 1 |
| Battini, R | 2 |
| Cioni, G | 3 |
| Pizzorusso, T | 1 |
| Baroncelli, L | 1 |
| Lopez-Marin, L | 1 |
| Wu, HC | 1 |
| Dachet, F | 1 |
| Ghoddoussi, F | 1 |
| Bagla, S | 1 |
| Fuerst, D | 1 |
| Stanley, JA | 1 |
| Galloway, MP | 1 |
| Loeb, JA | 1 |
| Naldi, I | 1 |
| Bisulli, F | 1 |
| Testa, C | 1 |
| Rizzo, G | 1 |
| Ferri, L | 1 |
| Gramegna, LL | 1 |
| Licchetta, L | 1 |
| Lodi, R | 1 |
| Tonon, C | 1 |
| Tinuper, P | 1 |
| Hall, J | 1 |
| Frenguelli, BG | 1 |
| Barta, H | 1 |
| Jermendy, A | 1 |
| Kolossvary, M | 1 |
| Kozak, LR | 1 |
| Lakatos, A | 1 |
| Meder, U | 1 |
| Szabo, M | 1 |
| Rudas, G | 1 |
| Peng, WF | 1 |
| Ding, J | 1 |
| Mao, LY | 1 |
| Li, X | 1 |
| Liang, L | 1 |
| Chen, CZ | 1 |
| Cheng, WZ | 1 |
| Fan, W | 1 |
| Wang, X | 1 |
| Reid, CA | 1 |
| Mullen, S | 1 |
| Kim, TH | 1 |
| Petrou, S | 1 |
| Eldin, EE | 1 |
| Elshebiny, HA | 1 |
| Mohamed, TM | 1 |
| Abdel-Aziz, MA | 1 |
| El-Readi, MZ | 1 |
| Nozaki, F | 1 |
| Kumada, T | 1 |
| Shibata, M | 1 |
| Fujii, T | 1 |
| Wada, T | 1 |
| Osaka, H | 1 |
| Tschampa, HJ | 1 |
| Urbach, H | 1 |
| Träber, F | 1 |
| Sprinkart, AM | 1 |
| Greschus, S | 1 |
| Malter, MP | 1 |
| Surges, R | 1 |
| Gieseke, J | 1 |
| Block, W | 1 |
| Juhász, C | 1 |
| Hu, J | 1 |
| Xuan, Y | 1 |
| Chugani, HT | 1 |
| Romariz, SA | 1 |
| Paiva, DS | 1 |
| Galindo, LT | 1 |
| Barnabé, GF | 1 |
| Guedes, VA | 1 |
| Borlongan, CV | 1 |
| Longo, BM | 1 |
| Stern, WM | 1 |
| Winston, JS | 1 |
| Murphy, E | 1 |
| Cross, JH | 1 |
| Sander, JW | 1 |
| Fons, C | 2 |
| Sempere, A | 2 |
| Arias, A | 2 |
| López-Sala, A | 1 |
| Póo, P | 2 |
| Pineda, M | 2 |
| Mas, A | 1 |
| Vilaseca, MA | 2 |
| Salomons, GS | 5 |
| Ribes, A | 2 |
| Artuch, R | 2 |
| Campistol, J | 2 |
| Ozisik, HI | 1 |
| Sarac, K | 1 |
| Ozcan, C | 1 |
| Valayannopoulos, V | 1 |
| Boddaert, N | 1 |
| Mention, K | 1 |
| Touati, G | 1 |
| Barbier, V | 1 |
| Chabli, A | 1 |
| Sedel, F | 1 |
| Kaplan, J | 1 |
| Dufier, JL | 1 |
| Seidenwurm, D | 1 |
| Rabier, D | 1 |
| Saudubray, JM | 1 |
| de Lonlay, P | 1 |
| Pan, JW | 2 |
| Zaveri, HP | 1 |
| Spencer, DD | 2 |
| Hetherington, HP | 2 |
| Spencer, SS | 1 |
| Sanmartí, FX | 1 |
| Merinero, B | 1 |
| Le Fur, Y | 1 |
| Nicoli, F | 1 |
| Guye, M | 1 |
| Confort-Gouny, S | 1 |
| Cozzone, PJ | 1 |
| Kober, F | 1 |
| Nasrallah, F | 1 |
| Feki, M | 1 |
| Kaabachi, N | 1 |
| Mercimek-Mahmutoglu, S | 2 |
| Connolly, MB | 1 |
| Poskitt, KJ | 1 |
| Horvath, GA | 1 |
| Lowry, N | 1 |
| Casey, B | 1 |
| Sinclair, G | 1 |
| Davis, C | 1 |
| Jakobs, C | 4 |
| Stockler-Ipsiroglu, S | 2 |
| Kim, DW | 1 |
| Yeo, SI | 1 |
| Ryu, HJ | 1 |
| Kim, JE | 1 |
| Song, HK | 1 |
| Kwon, OS | 1 |
| Choi, SY | 1 |
| Kang, TC | 1 |
| Striano, P | 1 |
| Morana, G | 1 |
| Pezzella, M | 1 |
| Bellini, T | 1 |
| Rossi, A | 2 |
| Saraiva, AL | 1 |
| Ferreira, AP | 1 |
| Silva, LF | 1 |
| Hoffmann, MS | 1 |
| Dutra, FD | 1 |
| Furian, AF | 1 |
| Oliveira, MS | 1 |
| Fighera, MR | 1 |
| Royes, LF | 1 |
| Lee, EM | 1 |
| Park, GY | 1 |
| Im, KC | 1 |
| Kim, ST | 1 |
| Woo, CW | 1 |
| Chung, JH | 1 |
| Kim, KS | 1 |
| Kim, JS | 1 |
| Shon, YM | 1 |
| Kim, YI | 1 |
| Kang, JK | 1 |
| Udow, S | 1 |
| Bunge, M | 1 |
| Ryner, L | 1 |
| Mhanni, AA | 1 |
| Salman, MS | 1 |
| Leuzzi, V | 4 |
| Mastrangelo, M | 1 |
| Ziyeh, S | 1 |
| Thiel, T | 1 |
| Spreer, J | 1 |
| Klisch, J | 1 |
| Schumacher, M | 1 |
| Chang, L | 1 |
| Cloak, CC | 1 |
| Ernst, T | 1 |
| Kim, JH | 1 |
| Mueller, SG | 4 |
| D Laxer, K | 1 |
| Barakos, JA | 2 |
| Cashdollar, N | 3 |
| Flenniken, DL | 2 |
| Vermathen, P | 2 |
| Matson, GB | 2 |
| Weiner, MW | 4 |
| Shirayama, Y | 1 |
| Takahashi, S | 1 |
| Minabe, Y | 1 |
| Ogino, T | 1 |
| Briellmann, RS | 1 |
| Wellard, RM | 1 |
| Jackson, GD | 1 |
| Laxer, KD | 2 |
| Lopez, RC | 1 |
| Schuff, N | 1 |
| Meyerhoff, DJ | 1 |
| Mueller, S | 1 |
| Chao, L | 1 |
| Sacrey, DT | 1 |
| Laxer, K | 1 |
| Stoeckler-Ipsiroglu, S | 1 |
| Adami, A | 1 |
| Appleton, R | 1 |
| Araújo, HC | 1 |
| Duran, M | 1 |
| Ensenauer, R | 1 |
| Fernandez-Alvarez, E | 1 |
| Garcia, P | 1 |
| Grolik, C | 1 |
| Item, CB | 1 |
| Marquardt, I | 1 |
| Mühl, A | 1 |
| Saelke-Kellermann, RA | 1 |
| Schulze, A | 2 |
| Surtees, R | 1 |
| van der Knaap, MS | 2 |
| Vasconcelos, R | 1 |
| Verhoeven, NM | 2 |
| Vilarinho, L | 1 |
| Wilichowski, E | 1 |
| Mancardi, MM | 1 |
| Caruso, U | 1 |
| Schiaffino, MC | 1 |
| Baglietto, MG | 1 |
| Battaglia, FM | 1 |
| Zara, F | 1 |
| Veneselli, E | 1 |
| Gaggero, R | 1 |
| Yapici, Z | 1 |
| Dörtcan, N | 1 |
| Baykan, BB | 1 |
| Okan, F | 1 |
| Dinçer, A | 1 |
| Baykal, C | 1 |
| Eraksoy, M | 1 |
| Roach, S | 1 |
| Hiremath, GK | 1 |
| Najm, IM | 1 |
| Hojo, Y | 1 |
| Breiter, SN | 1 |
| Arroyo, S | 1 |
| Mathews, VP | 1 |
| Lesser, RP | 1 |
| Bryan, RN | 1 |
| Barker, PB | 1 |
| Gadian, DG | 1 |
| Kuzniecky, R | 1 |
| Hetherington, H | 1 |
| Pan, J | 1 |
| Hugg, J | 1 |
| Palmer, C | 1 |
| Gilliam, F | 1 |
| Faught, E | 1 |
| Morawetz, R | 1 |
| Hess, T | 1 |
| Wevers, R | 1 |
| Mayatepek, E | 1 |
| Bachert, P | 1 |
| Marescau, B | 1 |
| Knopp, MV | 1 |
| De Deyn, PP | 1 |
| Bremer, HJ | 1 |
| Rating, D | 1 |
| Maaswinkel-Mooij, P | 1 |
| Pouwels, PJ | 1 |
| Onkenhout, W | 1 |
| Peeters, EA | 1 |
| McLean, MA | 2 |
| Woermann, FG | 2 |
| Barker, GJ | 2 |
| Duncan, JS | 2 |
| Mizuno, S | 1 |
| Takahashi, Y | 1 |
| Kato, Z | 1 |
| Goto, H | 1 |
| Kondo, N | 1 |
| Hoshi, H | 1 |
| Bianchi, MC | 1 |
| Tosetti, M | 1 |
| Carducci, C | 1 |
| Cerquiglini, CA | 1 |
| Antonozzi, I | 1 |
| Bartlett, PA | 1 |
| Weber, OM | 1 |
| Duc, CO | 1 |
| Weber, B | 1 |
| Meier, D | 1 |
| Russ, W | 1 |
| Boesiger, P | 1 |
| Wieser, HG | 1 |
| Pellock, JM | 1 |
| Glauser, TA | 1 |
| Bebin, EM | 1 |
| Fountain, NB | 1 |
| Ritter, FJ | 1 |
| Coupez, RM | 1 |
| Shields, WD | 1 |
| Peeling, J | 1 |
| Sutherland, G | 1 |
| Berlet, HH | 1 |
| Pilz, H | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Remote Effects of Stroke on Cerebral Metabolism. Evaluation With Positron Emission Tomography and Proton Magnetic Resonance Spectroscopy[NCT00063180] | 70 participants | Observational | 2003-06-19 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
9 reviews available for creatine and Epilepsy
| Article | Year |
|---|---|
[Metabolic approach in epileptic encephalopathies in infants].
Topics: Age of Onset; Biotin; Brain Diseases, Metabolic; Brain Diseases, Metabolic, Inborn; Child, Preschool | 2017 |
Epilepsy, energy deficiency and new therapeutic approaches including diet.
Topics: Adenosine Triphosphatases; Adenosine Triphosphate; Astrocytes; Creatine; Diet, Ketogenic; Energy Int | 2014 |
Creatine and creatine deficiency syndromes: biochemical and clinical aspects.
Topics: Amidinotransferases; Amino Acid Metabolism, Inborn Errors; Autistic Disorder; Child; Creatine; Epile | 2010 |
Inborn errors of creatine metabolism and epilepsy.
Topics: Amidinotransferases; Amino Acid Metabolism, Inborn Errors; Animals; Brain Diseases, Metabolic, Inbor | 2013 |
Inborn errors of creatine metabolism and epilepsy: clinical features, diagnosis, and treatment.
Topics: Amidinotransferases; Brain; Child; Clinical Laboratory Techniques; Creatine; Electroencephalography; | 2002 |
Magnetic resonance spectroscopy studies of GABA in neuropsychiatric disorders.
Topics: Anxiety Disorders; Brain; Brain Chemistry; Creatine; Depressive Disorder; Epilepsy; GABA Agents; gam | 2003 |
Seizure-associated abnormalities in epilepsy: evidence from MR imaging.
Topics: Adult; Aspartic Acid; Atrophy; Brain; Brain Diseases; Brain Edema; Choline; Creatine; Diffusion Magn | 2005 |
N-acetylaspartate as a marker of neuronal injury in neurodegenerative disease.
Topics: Aging; Alcoholism; Amyotrophic Lateral Sclerosis; Aspartic Acid; Biomarkers; Brain; Brain Injuries; | 2006 |
Magnetic resonance spectroscopy in animal models of epilepsy.
Topics: Animals; Aspartic Acid; Brain; Carbon Isotopes; Choline; Creatine; Disease Models, Animal; Epilepsy; | 2007 |
4 trials available for creatine and Epilepsy
| Article | Year |
|---|---|
Quantitative analysis of short echo time (1)H-MRSI of cerebral gray and white matter.
Topics: Adult; Aspartic Acid; Brain; Brain Chemistry; Calibration; Cerebrospinal Fluid; Choline; Creatine; D | 2000 |
Quantitative short echo time proton magnetic resonance spectroscopic imaging study of malformations of cortical development causing epilepsy.
Topics: Adult; Analysis of Variance; Aspartic Acid; Cerebral Cortex; Choline; Creatine; Dipeptides; Epilepsy | 2001 |
Effects of vigabatrin on brain GABA+/CR signals in patients with epilepsy monitored by 1H-NMR-spectroscopy: responder characteristics.
Topics: Adolescent; Adult; Anticonvulsants; Brain; Brain Chemistry; Carnosine; Creatine; Epilepsy; Epilepsy, | 2001 |
Pharmacokinetic study of levetiracetam in children.
Topics: Adult; Age Factors; Anticonvulsants; Child; Creatine; Epilepsy; Female; Humans; Levetiracetam; Male; | 2001 |
46 other studies available for creatine and Epilepsy
| Article | Year |
|---|---|
Glutamic Acid and Total Creatine as Predictive Markers for Epilepsy in Glioblastoma by Using Magnetic Resonance Spectroscopy Before Surgery.
Topics: Creatine; Epilepsy; Glioblastoma; Glutamic Acid; Glutamine; Humans; Magnetic Resonance Imaging; Magn | 2022 |
Insights into the development of pentylenetetrazole-induced epileptic seizures from dynamic metabolomic changes.
Topics: Alanine; Animals; Anticonvulsants; Asparagine; Citrates; Creatine; Creatinine; Disease Models, Anima | 2022 |
[Clinical features and SLC6A8 gene mutations of cerebral creatine deficiency syndrome I: an analysis of two families].
Topics: Child; Child, Preschool; Creatine; Epilepsy; Genetic Testing; Humans; Male; Mutation; Nerve Tissue P | 2020 |
Cyclocreatine treatment ameliorates the cognitive, autistic and epileptic phenotype in a mouse model of Creatine Transporter Deficiency.
Topics: Animals; Autistic Disorder; Blood-Brain Barrier; Brain Diseases, Metabolic, Inborn; Cerebrovascular | 2020 |
Altered metabolomic-genomic signature: A potential noninvasive biomarker of epilepsy.
Topics: Adolescent; Biomarkers; Brain; Child; Child, Preschool; Choline; Creatine; Epilepsy; Female; Genetic | 2017 |
Proton MR Spectroscopy in Patients With Sleep-Related Hypermotor Epilepsy (SHE): Evidence of Altered Cingulate Cortex Metabolism.
Topics: Adult; Aspartic Acid; Case-Control Studies; Creatine; Epilepsy; Female; Gyrus Cinguli; Humans; Magne | 2017 |
The combination of ribose and adenine promotes adenosine release and attenuates the intensity and frequency of epileptiform activity in hippocampal slices: Evidence for the rapid depletion of cellular ATP during electrographic seizures.
Topics: Adenine; Adenosine; Adenosine Triphosphate; Animals; Creatine; Electrophysiological Phenomena; Epile | 2018 |
Prognostic value of early, conventional proton magnetic resonance spectroscopy in cooled asphyxiated infants.
Topics: Aspartic Acid; Brain; Creatine; Epilepsy; Female; Hearing Loss; Hospital Mortality; Humans; Hypother | 2018 |
Increased ratio of glutamate/glutamine to creatine in the right hippocampus contributes to depressive symptoms in patients with epilepsy.
Topics: Adolescent; Adult; Creatine; Depression; Epilepsy; Female; Functional Laterality; Glutamic Acid; Glu | 2013 |
The role of antiepileptic drugs in free radicals generation and antioxidant levels in epileptic patients.
Topics: Adolescent; Adult; Anticonvulsants; Antioxidants; Child; Creatine; Epilepsy; Female; Follow-Up Studi | 2016 |
[A family with creatine transporter deficiency diagnosed with urinary creatine/creatinine ratio and the family history: the third Japanese familial case].
Topics: Adolescent; Brain Diseases, Metabolic, Inborn; Child; Creatine; Creatinine; Epilepsy; Female; Humans | 2015 |
Proton magnetic resonance spectroscopy in focal cortical dysplasia at 3T.
Topics: Adolescent; Adult; Aged; Aspartic Acid; Brain; Child, Preschool; Choline; Creatine; Drug Resistant E | 2015 |
Imaging increased glutamate in children with Sturge-Weber syndrome: Association with epilepsy severity.
Topics: Aspartic Acid; Brain; Child; Child, Preschool; Creatine; Epilepsy; Female; Fluorodeoxyglucose F18; F | 2016 |
Medial Ganglionic Eminence Cells Freshly Obtained or Expanded as Neurospheres Show Distinct Cellular and Molecular Properties in Reducing Epileptic Seizures.
Topics: Animals; Cell Differentiation; Cells, Cultured; Creatine; Disease Models, Animal; Embryo, Mammalian; | 2017 |
Guanidinoacetate methyltransferase (GAMT) deficiency: a rare but treatable epilepsy.
Topics: Adult; Creatine; Epilepsy; Guanidinoacetate N-Methyltransferase; Humans; Language Development Disord | 2017 |
Arginine supplementation in four patients with X-linked creatine transporter defect.
Topics: Administration, Oral; Adolescent; Age of Onset; Arginine; Child; Chromosomes, Human, X; Creatine; Di | 2008 |
Single-voxel magnetic resonance spectroscopy of brain tissue adjacent to arachnoid cysts of epileptic patients.
Topics: Adolescent; Adult; Arachnoid Cysts; Aspartic Acid; Brain; Brain Mapping; Child; Choline; Creatine; E | 2008 |
Secondary creatine deficiency in ornithine delta-aminotransferase deficiency.
Topics: Adolescent; Adult; Aggression; Apraxias; Brain; Child; Creatine; Epilepsy; Female; Gyrate Atrophy; H | 2009 |
Intracranial EEG power and metabolism in human epilepsy.
Topics: Adolescent; Adult; Aspartic Acid; Brain; Creatine; Electrodes, Implanted; Electroencephalography; En | 2009 |
Epilepsy spectrum in cerebral creatine transporter deficiency.
Topics: Amino Acid Metabolism, Inborn Errors; Brain; Child, Preschool; Creatine; Electroencephalography; Epi | 2009 |
Grid-free interactive and automated data processing for MR chemical shift imaging data.
Topics: Aspartic Acid; Brain; Brain Mapping; Brain Neoplasms; Case-Control Studies; Choline; Creatine; Elect | 2010 |
Treatment of intractable epilepsy in a female with SLC6A8 deficiency.
Topics: Arginine; Child; Creatine; Drug Therapy, Combination; Epilepsy; Female; Glycine; Heterozygote; Human | 2010 |
Effects of creatine and β-guanidinopropionic acid and alterations in creatine transporter and creatine kinases expression in acute seizure and chronic epilepsy models.
Topics: Acute Disease; Animals; CA1 Region, Hippocampal; Chronic Disease; Creatine; Creatine Kinase; Disease | 2010 |
Rhombencephalosynapsis in a patient with mental retardation, epilepsy, and dysmorphisms.
Topics: Adolescent; Aspartic Acid; Body Dysmorphic Disorders; Creatine; Epilepsy; Humans; Intellectual Disab | 2011 |
Creatine reduces oxidative stress markers but does not protect against seizure susceptibility after severe traumatic brain injury.
Topics: Animals; Brain Injuries; Creatine; Dietary Supplements; Disease Models, Animal; Electroencephalograp | 2012 |
Changes in glucose metabolism and metabolites during the epileptogenic process in the lithium-pilocarpine model of epilepsy.
Topics: Animals; Aspartic Acid; Brain Mapping; Choline; Creatine; Disease Models, Animal; Epilepsy; Fluorode | 2012 |
Prolonged survival and serial magnetic resonance imaging/magnetic resonance spectroscopy changes in infantile Krabbe disease.
Topics: Anticonvulsants; Aspartic Acid; Brain Chemistry; Choline; Combined Modality Therapy; Creatine; DNA M | 2012 |
Valproate-induced encephalopathy: assessment with MR imaging and 1H MR spectroscopy.
Topics: Adult; Anticonvulsants; Aspartic Acid; Brain; Brain Diseases, Metabolic; Choline; Creatine; Epilepsy | 2002 |
1H and 31P spectroscopic imaging of epilepsy: spectroscopic and histologic correlations.
Topics: Adult; Amygdala; Aspartic Acid; Brain; Choline; Creatine; Epilepsy; Epilepsy, Temporal Lobe; Female; | 2004 |
Identification of the epileptogenic lobe in neocortical epilepsy with proton MR spectroscopic imaging.
Topics: Adolescent; Adult; Aspartic Acid; Brain Mapping; Choline; Creatine; Electroencephalography; Epilepsi | 2004 |
In vitro 1H NMR spectroscopy shows an increase in N-acetylaspartylglutamate and glutamine content in the hippocampus of amygdaloid-kindled rats.
Topics: Amino Acids; Amygdala; Animals; Creatine; Dipeptides; Disease Models, Animal; Energy Metabolism; Epi | 2005 |
Metabolic characteristics of cortical malformations causing epilepsy.
Topics: Adolescent; Adult; Aspartic Acid; Cerebral Cortex; Choline; Creatine; Epilepsy; Humans; Image Proces | 2005 |
Spectroscopic evidence of hippocampal abnormalities in neocortical epilepsy.
Topics: Adolescent; Adult; Aspartic Acid; Choline; Creatine; Epilepsy; Female; Functional Laterality; Hippoc | 2006 |
GAMT deficiency: features, treatment, and outcome in an inborn error of creatine synthesis.
Topics: Adolescent; Adult; Child; Creatine; Epilepsy; Female; Glycine; Guanidinoacetate N-Methyltransferase; | 2006 |
Severe epilepsy in X-linked creatine transporter defect (CRTR-D).
Topics: Anticonvulsants; Brain; Child, Preschool; Creatine; Electroencephalography; Epilepsy; Genes, X-Linke | 2007 |
Neurological aspects of tuberous sclerosis in relation to MRI/MR spectroscopy findings in children with epilepsy.
Topics: Adolescent; Aspartic Acid; Child; Child, Preschool; Creatine; Epilepsy; Female; Humans; Infant; Magn | 2007 |
Subject groups high and low in urinary selenium levels: workers exposed to heavy metals and patients with cancer and epilepsy.
Topics: Creatine; Environmental Exposure; Epilepsy; Humans; Industry; Metals; Neoplasms; Selenium | 1981 |
Proton MR spectroscopy in patients with seizure disorders.
Topics: Adolescent; Adult; Aspartic Acid; Brain; Cerebral Cortex; Child; Child, Preschool; Choline; Creatine | 1994 |
N-acetylaspartate and epilepsy.
Topics: Adult; Aspartic Acid; Brain Damage, Chronic; Brain Mapping; Child; Choline; Creatine; Dominance, Cer | 1995 |
Proton spectroscopic imaging at 4.1 tesla in patients with malformations of cortical development and epilepsy.
Topics: Acetylation; Adolescent; Adult; Brain; Brain Neoplasms; Cerebral Cortex; Choline; Choristoma; Creati | 1997 |
Creatine deficiency syndrome caused by guanidinoacetate methyltransferase deficiency: diagnostic tools for a new inborn error of metabolism.
Topics: Amino Acid Metabolism, Inborn Errors; Brain; Cells, Cultured; Child, Preschool; Creatine; Creatinine | 1997 |
Mental retardation and behavioral problems as presenting signs of a creatine synthesis defect.
Topics: Aspartic Acid; Body Fluids; Brain Diseases, Metabolic; Child, Preschool; Creatine; Diagnosis, Differ | 2000 |
Magnetic resonance spectroscopy of tubers in patients with tuberous sclerosis.
Topics: Adult; Age Factors; Aspartic Acid; Case-Control Studies; Child; Child, Preschool; Creatine; Disease | 2000 |
Brain creatine depletion: guanidinoacetate methyltransferase deficiency (improving with creatine supplementation).
Topics: Brain Chemistry; Child, Preschool; Creatine; Epilepsy; Guanidinoacetate N-Methyltransferase; Humans; | 2000 |
High-resolution 1H NMR spectroscopy studies of extracts of human cerebral neoplasms.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Alanine; Amino Acids; Astrocytoma; Brain; Brain Neoplasm | 1992 |
[Significance of plasma creatine and neurologic disorders for the creatine level of cerebrospinal fluid in man].
Topics: Amyotrophic Lateral Sclerosis; Creatine; Dementia; Encephalitis; Epilepsy; Humans; Meningitis; Multi | 1972 |