creatine has been researched along with Depressive Disorder in 27 studies
Depressive Disorder: An affective disorder manifested by either a dysphoric mood or loss of interest or pleasure in usual activities. The mood disturbance is prominent and relatively persistent.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Adolescent major depressive disorder (MDD) is a life-threatening brain disease with limited interventions." | 6.76 | Open-label adjunctive creatine for female adolescents with SSRI-resistant major depressive disorder: a 31-phosphorus magnetic resonance spectroscopy study. ( Fiedler, KK; Hellem, TL; Jeong, EK; Kondo, DG; Renshaw, PF; Shi, X; Sung, YH, 2011) |
| "In an attempt to chemically estimate cerebral energy metabolism, creatine and creatinine was measured in cerebrospinal fluid and plasma of up to 135 patients with RDC diagnoses of major depressive disorders." | 3.67 | Creatinine and creatine in CSF: indices of brain energy metabolism in depression. Short note. ( Agren, H; Niklasson, F, 1988) |
| "Adolescent major depressive disorder (MDD) is a life-threatening brain disease with limited interventions." | 2.76 | Open-label adjunctive creatine for female adolescents with SSRI-resistant major depressive disorder: a 31-phosphorus magnetic resonance spectroscopy study. ( Fiedler, KK; Hellem, TL; Jeong, EK; Kondo, DG; Renshaw, PF; Shi, X; Sung, YH, 2011) |
| "Creatine was previously shown to produce an antidepressant-like effect in the tail suspension test through a modulation of the dopaminergic system." | 1.39 | Evidence for the involvement of 5-HT1A receptor in the acute antidepressant-like effect of creatine in mice. ( Cunha, MP; Machado, DG; Oliveira, Á; Pazini, FL; Rodrigues, AL, 2013) |
| "Partial or total overnight sleep deprivation produces immediate mood improvement in about 50% of patients with depression, but not in healthy controls." | 1.35 | Effects of overnight sleep restriction on brain chemistry and mood in women with unipolar depression and healthy controls. ( Bartha, R; Bernier, D; Devarajan, S; Macmaster, FP; Rusak, B; Schmidt, MH, 2009) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 4 (14.81) | 18.7374 |
| 1990's | 3 (11.11) | 18.2507 |
| 2000's | 10 (37.04) | 29.6817 |
| 2010's | 10 (37.04) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Pazini, FL | 2 |
| Cunha, MP | 2 |
| Rodrigues, ALS | 1 |
| Liu, W | 1 |
| Yu, H | 1 |
| Jiang, B | 1 |
| Zheng, L | 1 |
| Yu, S | 1 |
| Pan, B | 1 |
| Yu, R | 1 |
| Bogdanova, OV | 1 |
| Abdullah, O | 1 |
| Kanekar, S | 1 |
| Bogdanov, VB | 1 |
| Prescot, AP | 1 |
| Renshaw, PF | 4 |
| Hellem, TL | 2 |
| Sung, YH | 2 |
| Shi, XF | 1 |
| Pett, MA | 1 |
| Latendresse, G | 1 |
| Morgan, J | 1 |
| Huber, RS | 1 |
| Kuykendall, D | 1 |
| Lundberg, KJ | 1 |
| Guo, Z | 1 |
| Zhang, J | 3 |
| Liu, X | 1 |
| Hou, H | 1 |
| Cao, Y | 1 |
| Wei, F | 1 |
| Li, J | 2 |
| Chen, X | 1 |
| Shen, Y | 1 |
| Chen, W | 1 |
| Li, H | 1 |
| Xu, H | 1 |
| Zhang, Y | 1 |
| Guan, J | 1 |
| Xu, C | 1 |
| Shen, Z | 1 |
| Xiao, B | 1 |
| Liang, C | 1 |
| Chen, K | 1 |
| Wu, R | 1 |
| Hong, ST | 1 |
| Choi, CB | 1 |
| Park, C | 1 |
| Moon, HY | 1 |
| Hong, KS | 1 |
| Cheong, C | 1 |
| Chae, JH | 1 |
| Choe, BY | 1 |
| Kuang, WH | 1 |
| Zou, K | 1 |
| Deng, W | 1 |
| Li, T | 1 |
| Gong, QY | 1 |
| Sun, XL | 1 |
| Bernier, D | 1 |
| Bartha, R | 1 |
| Devarajan, S | 1 |
| Macmaster, FP | 1 |
| Schmidt, MH | 1 |
| Rusak, B | 1 |
| Herman-Sucharska, I | 1 |
| Werewka-Maczuga, A | 1 |
| Urbanik, A | 2 |
| Rachel, W | 1 |
| Siwek, M | 1 |
| Dudek, D | 1 |
| Zieba, A | 1 |
| D'Anci, KE | 1 |
| Allen, PJ | 1 |
| Kanarek, RB | 1 |
| Kondo, DG | 1 |
| Fiedler, KK | 1 |
| Shi, X | 1 |
| Jeong, EK | 1 |
| Oliveira, Á | 1 |
| Machado, DG | 1 |
| Rodrigues, AL | 1 |
| Chang, L | 1 |
| Cloak, CC | 1 |
| Ernst, T | 1 |
| OYEN, I | 1 |
| BOYLAN, JW | 1 |
| PRYCE, IG | 1 |
| Elderkin-Thompson, V | 1 |
| Thomas, MA | 2 |
| Binesh, N | 2 |
| Mintz, J | 2 |
| Haroon, E | 1 |
| Dunkin, JJ | 1 |
| Kumar, A | 2 |
| Hwang, S | 1 |
| Kado, H | 1 |
| Kimura, H | 1 |
| Murata, T | 1 |
| Nagata, K | 1 |
| Kanno, I | 1 |
| Amital, D | 1 |
| Vishne, T | 1 |
| Rubinow, A | 1 |
| Levine, J | 2 |
| Glodzik-Sobanska, L | 1 |
| Slowik, A | 1 |
| McHugh, P | 1 |
| Sobiecka, B | 1 |
| Kozub, J | 1 |
| Rich, KE | 1 |
| Szczudlik, A | 1 |
| Niklasson, F | 2 |
| Agren, H | 2 |
| Hamakawa, H | 1 |
| Kato, T | 1 |
| Murashita, J | 1 |
| Kato, N | 1 |
| Sonawalla, SB | 1 |
| Moore, CM | 1 |
| Alpert, JE | 1 |
| Nierenberg, AA | 1 |
| Rosenbaum, JF | 1 |
| Fava, M | 1 |
| Panchalingam, K | 1 |
| Rapoport, A | 1 |
| Gershon, S | 1 |
| McClure, RJ | 1 |
| Pettegrew, JW | 1 |
| Sharma, R | 1 |
| Venkatasubramanian, PN | 1 |
| Bárány, M | 1 |
| Davis, JM | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Creatine as a Treatment Option for Depression in Methamphetamine Using Females[NCT01514630] | Phase 4 | 14 participants (Actual) | Interventional | 2013-01-31 | Completed | ||
| Creatine Augmentation in Female & Male Veterans With Selective Serotonin Reuptake Inhibitor-Resistant Major Depressive Disorder[NCT01175616] | Phase 4 | 0 participants (Actual) | Interventional | 2012-09-30 | Withdrawn (stopped due to Study withdrawn from ClinicalTrials.gov.) | ||
| Adjunctive Creatine Treatment for Adolescent Females With Major Depressive Disorder Who Are Non-Responders to Fluoxetine or Escitalopram: A Magnetic Resonance Spectroscopy Study[NCT00851006] | Phase 2 | 13 participants (Actual) | Interventional | 2009-04-30 | Completed | ||
| Placebo-Controlled Trial of Creatine Augmentation for Adolescent Females With Treatment-Resistant Major Depressive Disorder: a Magnetic Resonance Spectroscopy Study[NCT02134808] | Phase 4 | 71 participants (Actual) | Interventional | 2014-11-21 | Completed | ||
| Remote Effects of Stroke on Cerebral Metabolism. Evaluation With Positron Emission Tomography and Proton Magnetic Resonance Spectroscopy[NCT00063180] | 70 participants | Observational | 2003-06-19 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
"Eight weeks of oral creatine supplementation will result in improvements in Hamilton Depression Rating Scale (HAMD) in female methamphetamine users. HAMD scoring is based on 17 items. Minimum score is 0 and maximum 52. A score of 0-7 is considered to be normal. Scores of 20 or higher indicate moderate or severe depression.~0-7 = Normal 8-13 = Mild Depression 14-18 = Moderate Depression 19-22 = Severe Depression~≥ 23 = Very Severe Depression" (NCT01514630)
Timeframe: Over the course of eight weeks. Depression rating scores will be measured weekly for eight weeks for each subject enrolled.
| Intervention | Units on a scale (Mean) | |||||||
|---|---|---|---|---|---|---|---|---|
| Baseline | week 2 | week 3 | week 4 | week 5 | week 6 | week 7 | week 8 | |
| Creatine Monohydrate | 16.86 | 10.71 | 9.81 | 7.33 | 8.35 | 7.73 | 6.28 | 7.36 |
Phosphocreatine Metabolite is a phosphorylated creatine molecule that plays a role in the production of the energy in the body. Phosphocreatine (PCr) metabolite was quantified by calculating the ratio of PCr over total phosphorus resonance from 31-Phosphorus Magnetic Resonance Spectroscopy. (NCT00851006)
Timeframe: 8 weeks
| Intervention | ratio of PCr and total phosphorus (Mean) | |
|---|---|---|
| Baseline | After 8 weeks | |
| Healthy Control Group | 0.1556 | 0.1558 |
| Open Label Creatine Treatment | 0.1513 | 0.1610 |
The CDRS-R is a 17-item scale, with items ranging from 1 to 5 or 1 to 7 (possible total score from 17 to 113), rated by a clinician via interviews with the child or parent. Scores ≥40 are indicative of depression, whereas scores ≤28 is often used to define remission (NCT00851006)
Timeframe: 8 weeks
| Intervention | Units on a scale (Mean) | |
|---|---|---|
| Baseline | After 8 week Creatine treatment | |
| Open Label Creatine Treatment | 69 | 30.6 |
3 reviews available for creatine and Depressive Disorder
| Article | Year |
|---|---|
The possible beneficial effects of creatine for the management of depression.
Topics: Animals; Creatine; Depressive Disorder; Dietary Supplements; Humans | 2019 |
A potential role for creatine in drug abuse?
Topics: Brain; Brain Injuries; Creatine; Depressive Disorder; Dietary Supplements; Energy Metabolism; Humans | 2011 |
Magnetic resonance spectroscopy studies of GABA in neuropsychiatric disorders.
Topics: Anxiety Disorders; Brain; Brain Chemistry; Creatine; Depressive Disorder; Epilepsy; GABA Agents; gam | 2003 |
2 trials available for creatine and Depressive Disorder
| Article | Year |
|---|---|
Open-label adjunctive creatine for female adolescents with SSRI-resistant major depressive disorder: a 31-phosphorus magnetic resonance spectroscopy study.
Topics: Adolescent; Antidepressive Agents; Creatine; Depressive Disorder; Depressive Disorder, Major; Female | 2011 |
Open-label adjunctive creatine for female adolescents with SSRI-resistant major depressive disorder: a 31-phosphorus magnetic resonance spectroscopy study.
Topics: Adolescent; Antidepressive Agents; Creatine; Depressive Disorder; Depressive Disorder, Major; Female | 2011 |
Open-label adjunctive creatine for female adolescents with SSRI-resistant major depressive disorder: a 31-phosphorus magnetic resonance spectroscopy study.
Topics: Adolescent; Antidepressive Agents; Creatine; Depressive Disorder; Depressive Disorder, Major; Female | 2011 |
Open-label adjunctive creatine for female adolescents with SSRI-resistant major depressive disorder: a 31-phosphorus magnetic resonance spectroscopy study.
Topics: Adolescent; Antidepressive Agents; Creatine; Depressive Disorder; Depressive Disorder, Major; Female | 2011 |
Open-label adjunctive creatine for female adolescents with SSRI-resistant major depressive disorder: a 31-phosphorus magnetic resonance spectroscopy study.
Topics: Adolescent; Antidepressive Agents; Creatine; Depressive Disorder; Depressive Disorder, Major; Female | 2011 |
Open-label adjunctive creatine for female adolescents with SSRI-resistant major depressive disorder: a 31-phosphorus magnetic resonance spectroscopy study.
Topics: Adolescent; Antidepressive Agents; Creatine; Depressive Disorder; Depressive Disorder, Major; Female | 2011 |
Open-label adjunctive creatine for female adolescents with SSRI-resistant major depressive disorder: a 31-phosphorus magnetic resonance spectroscopy study.
Topics: Adolescent; Antidepressive Agents; Creatine; Depressive Disorder; Depressive Disorder, Major; Female | 2011 |
Open-label adjunctive creatine for female adolescents with SSRI-resistant major depressive disorder: a 31-phosphorus magnetic resonance spectroscopy study.
Topics: Adolescent; Antidepressive Agents; Creatine; Depressive Disorder; Depressive Disorder, Major; Female | 2011 |
Open-label adjunctive creatine for female adolescents with SSRI-resistant major depressive disorder: a 31-phosphorus magnetic resonance spectroscopy study.
Topics: Adolescent; Antidepressive Agents; Creatine; Depressive Disorder; Depressive Disorder, Major; Female | 2011 |
Compounds containing cytosolic choline in the basal ganglia: a potential biological marker of true drug response to fluoxetine.
Topics: Adult; Ambulatory Care; Analysis of Variance; Basal Ganglia; Biomarkers; Choline; Creatine; Cytosol; | 1999 |
22 other studies available for creatine and Depressive Disorder
| Article | Year |
|---|---|
[Correlation of neurochemical metabolism with memory function in young adult patients with first-episode depression studied with proton magnetic resonance spectroscopy].
Topics: Adolescent; Adult; Aspartic Acid; Case-Control Studies; Creatine; Depressive Disorder; Female; Hippo | 2013 |
Neurochemical alterations in frontal cortex of the rat after one week of hypobaric hypoxia.
Topics: Alanine; Altitude; Animals; Corpus Striatum; Creatine; Depressive Disorder; Female; Frontal Lobe; Gl | 2014 |
Creatine as a Novel Treatment for Depression in Females Using Methamphetamine: A Pilot Study.
Topics: Adult; Amphetamine-Related Disorders; Antidepressive Agents; Brain; Creatine; Depressive Disorder; D | 2015 |
Neurometabolic characteristics in the anterior cingulate gyrus of Alzheimer's disease patients with depression: a (1)H magnetic resonance spectroscopy study.
Topics: Aged; Alzheimer Disease; Aspartic Acid; Cognition Disorders; Creatine; Depressive Disorder; Female; | 2015 |
Differential neurometabolite alterations in brains of medication-free individuals with bipolar disorder and those with unipolar depression: a two-dimensional proton magnetic resonance spectroscopy study.
Topics: Adult; Aspartic Acid; Bipolar Disorder; Choline; Creatine; Depressive Disorder; Female; Gyrus Cingul | 2016 |
Specific hippocampal choline decrease in an animal model of depression.
Topics: Animals; Aspartic Acid; Biomarkers; Choline; Creatine; Depressive Disorder; Hippocampus; Magnetic Re | 2009 |
[A proton magnetic spectroscopy research on hippocampus metabolisms in people with suicide-attempted depressions].
Topics: Adult; Aspartic Acid; Creatine; Depressive Disorder; Female; Hippocampus; Humans; Magnetic Resonance | 2009 |
Effects of overnight sleep restriction on brain chemistry and mood in women with unipolar depression and healthy controls.
Topics: Adult; Affect; Analysis of Variance; Aspartic Acid; Choline; Creatine; Depressive Disorder; Female; | 2009 |
[Usefulness of proton MR spectroscopy for determining diagnosis and treatment outcome in unipolar depressive disorder].
Topics: Adolescent; Adult; Choline; Creatine; Depressive Disorder; Frontal Lobe; Hippocampus; Humans; Magnet | 2010 |
Evidence for the involvement of 5-HT1A receptor in the acute antidepressant-like effect of creatine in mice.
Topics: Animals; Antidepressive Agents; Creatine; Depression; Depressive Disorder; Hindlimb Suspension; Huma | 2013 |
Renal clearance in the unanesthetized guinea pig: depression of inulin clearance by creatinine.
Topics: Creatine; Creatinine; Depression; Depressive Disorder; Guinea Pigs; Inulin; Kidney Function Tests | 1962 |
THE RELATIONSHIP BETWEEN 17-HYDROXYCORTICOSTEROID EXCRETION AND GLUCOSE UTILIZATION IN DEPRESSIONS.
Topics: 17-Hydroxycorticosteroids; Adrenal Cortex Hormones; Blood Glucose; Body Weight; Carbohydrate Metabol | 1964 |
Brain metabolites and cognitive function among older depressed and healthy individuals using 2D MR spectroscopy.
Topics: Age Factors; Aged; Aged, 80 and over; Brain; Case-Control Studies; Choline; Cognition; Creatine; Dep | 2004 |
Neurochemistry of late-life major depression: a pilot two-dimensional MR spectroscopic study.
Topics: Aged; Aged, 80 and over; Brain Chemistry; Choline; Creatine; Depressive Disorder; Female; Humans; Ma | 2004 |
Depressive psychosis: clinical usefulness of MR spectroscopy data in predicting prognosis.
Topics: Aged; Analysis of Variance; Antidepressive Agents; Area Under Curve; Aspartic Acid; Choline; Creatin | 2006 |
Observed effects of creatine monohydrate in a patient with depression and fibromyalgia.
Topics: Comorbidity; Creatine; Depressive Disorder; Drug Therapy, Combination; Female; Fibromyalgia; Humans; | 2006 |
Single voxel proton magnetic resonance spectroscopy in post-stroke depression.
Topics: Aged; Aspartic Acid; Cerebral Infarction; Choline; Creatine; Depressive Disorder; Dominance, Cerebra | 2006 |
Brain energy metabolism and blood-brain barrier permeability in depressive patients: analyses of creatine, creatinine, urate, and albumin in CSF and blood.
Topics: Adult; Aged; Albumins; Blood-Brain Barrier; Brain; Creatine; Creatinine; Depressive Disorder; Energy | 1984 |
Quantitative proton magnetic resonance spectroscopy of the basal ganglia in patients with affective disorders.
Topics: Adult; Aspartic Acid; Basal Ganglia; Bipolar Disorder; Choline; Creatine; Depressive Disorder; Femal | 1998 |
Increased cerebrospinal fluid glutamine levels in depressed patients.
Topics: Adolescent; Adult; Age Factors; Aged; Aged, 80 and over; Bipolar Disorder; Case-Control Studies; Cre | 2000 |
Proton magnetic resonance spectroscopy of the brain in schizophrenic and affective patients.
Topics: Adult; Aspartic Acid; Basal Ganglia; Bipolar Disorder; Choline; Creatine; Depressive Disorder; Energ | 1992 |
Creatinine and creatine in CSF: indices of brain energy metabolism in depression. Short note.
Topics: Adolescent; Adult; Age Factors; Aged; Brain; Creatine; Creatinine; Depressive Disorder; Energy Metab | 1988 |