creatine has been researched along with Depression in 53 studies
Depression: Depressive states usually of moderate intensity in contrast with MAJOR DEPRESSIVE DISORDER present in neurotic and psychotic disorders.
| Excerpt | Relevance | Reference |
|---|---|---|
| "DASS depression scores were negatively associated (a) with concentrations of creatine (but not other metabolites) in the prefrontal cortex and (b) with grey matter volume in the right superior medial frontal gyrus." | 8.02 | Relationship between depression, prefrontal creatine and grey matter volume. ( Allen, P; Barker, H; Daniju, Y; Faulkner, P; Kozhuharova, P; Lythgoe, DJ; Morgenroth, E; Orlov, N; Paioni, SL, 2021) |
| "Creatine monohydrate is actively being researched for its antidepressant effects, yet little is known about the link between dietary creatine and depression risk." | 7.96 | Dietary creatine intake and depression risk among U.S. adults. ( Bakian, AV; Huber, RS; Kondo, D; Renshaw, PF; Scholl, L, 2020) |
| " However, there were no associations between NAA/Cr, Glu/Cr, or Gln/Cr and either depression severity or lamotrigine treatment." | 7.91 | Lamotrigine Therapy and Biomarkers of Cerebral Energy Metabolism in Older Age Bipolar Depression. ( Forester, BP; Harper, DG; Jensen, E; Mellen, EJ; Ravichandran, C; Silveri, M, 2019) |
| "Proton magnetic resonance spectroscopy analysis showed that the ratio of glutamate/glutamine to creatine (Glx/Cr) in the right hippocampus was significantly increased in patients with moderate depression and correlated positively with HAMD scores." | 7.79 | Increased ratio of glutamate/glutamine to creatine in the right hippocampus contributes to depressive symptoms in patients with epilepsy. ( Chen, CZ; Cheng, WZ; Ding, J; Fan, W; Li, X; Liang, L; Mao, LY; Peng, WF; Wang, X, 2013) |
| "The intensity of convulsion was scored according to a seven-point scale ranging from stage 0-7." | 5.62 | Creatine attenuates seizure severity, anxiety and depressive-like behaviors in pentylenetetrazole kindled mice. ( Abiola, AL; Akhigbemen, AM; Chinazamoku, O; Igbe, I; Ogundepo, GE; Okwuofu, EO; Ozolua, RI, 2021) |
| "Creatine is an antioxidant, neuromodulator and key regulator of energy metabolism shown to improve depressive symptoms in humans and animals, especially in females." | 5.42 | Chronic high-dose creatine has opposing effects on depression-related gene expression and behavior in intact and sex hormone-treated gonadectomized male and female rats. ( Allen, PJ; DeBold, JF; Kanarek, RB; Rios, M, 2015) |
| "We investigated the antidepressant effect of creatine (CRE) and taurine (TAU) mixtures on behavioural changes and biomarkers in stress-induced depression in Drosophila melanogaster and a mouse model." | 3.96 | Creatine and taurine mixtures alleviate depressive-like behaviour in Drosophila melanogaster and mice via regulating Akt and ERK/BDNF pathways. ( Hong, KB; Jo, K; Kim, S; Suh, HJ, 2020) |
| " However, there were no associations between NAA/Cr, Glu/Cr, or Gln/Cr and either depression severity or lamotrigine treatment." | 3.91 | Lamotrigine Therapy and Biomarkers of Cerebral Energy Metabolism in Older Age Bipolar Depression. ( Forester, BP; Harper, DG; Jensen, E; Mellen, EJ; Ravichandran, C; Silveri, M, 2019) |
| "The benefits of creatine supplementation have been reported in a broad range of central nervous system diseases, including depression, although the mechanisms underlying these effects remain to be understood." | 3.85 | Creatine Prevents Corticosterone-Induced Reduction in Hippocampal Proliferation and Differentiation: Possible Implication for Its Antidepressant Effect. ( Azevedo, D; Brocardo, PS; Colla, A; Cunha, MP; de Oliveira, J; Gil-Mohapel, J; Pazini, FL; Ramos-Hryb, AB; Rodrigues, ALS; Rosa, JM, 2017) |
| " Concentrations of glutamate + glutamin (Glx), cholin (Cho), myoinositol (mIns), N-acetyl aspartate (NAA) expressed as ratio with creatine (Cr) and NAA were correlated with markers of disease activity (RIO score), Multiple Sclerosis Severity Scale (MSSS), Depressive-Severity Status Scale and Simple Numerical Fatigue Scale." | 3.85 | Hypothalamic damage in multiple sclerosis correlates with disease activity, disability, depression, and fatigue. ( Baranovičová, E; Bittšanský, M; Čierny, D; Hnilicová, P; Kantorová, E; Kurča, E; Nosáľ, V; Poláček, H; Sivák, Š; Zeleňák, K, 2017) |
| "Ketamine has emerged as a novel strategy to treat refractory depression, producing rapid remission, but elicits some side effects that limit its use." | 3.83 | Creatine, Similar to Ketamine, Counteracts Depressive-Like Behavior Induced by Corticosterone via PI3K/Akt/mTOR Pathway. ( Colla, AR; Cunha, MP; Lieberknecht, V; Oliveira, Á; Pazini, FL; Rodrigues, AL; Rosa, JM, 2016) |
| "The modulation of N-methyl-D-aspartate receptor (NMDAR) and L-arginine/nitric oxide (NO) pathway is a therapeutic strategy for treating depression and neurologic disorders that involves excitotoxicity." | 3.81 | The modulation of NMDA receptors and L-arginine/nitric oxide pathway is implicated in the anti-immobility effect of creatine in the tail suspension test. ( Bettio, LE; Budni, J; Cunha, MP; Lieberknecht, V; López, MG; Ludka, FK; Martín-de-Saavedra, MD; Oliveira, Á; Pazini, FL; Ramos-Hryb, AB; Rodrigues, AL; Rosa, JM; Tasca, CI, 2015) |
| "The benefits of creatine supplementation have been reported in a broad range of central nervous systems diseases, including depression." | 3.81 | Creatine, similarly to ketamine, affords antidepressant-like effects in the tail suspension test via adenosine A₁ and A2A receptor activation. ( Cunha, MP; Kaster, MP; Oliveira, Á; Pazini, FL; Ramos-Hryb, AB; Rodrigues, AL; Rosa, JM, 2015) |
| " Single-voxel magnetic resonance spectroscopy (MRS) was employed to measure glutamate concentrations normalized to creatine (Glu/Cr) in dACC and basal ganglia of 31 patients with hepatitis C before and after ∼ 1 month of either no treatment (n = 14) or treatment with IFN-alpha (n = 17)." | 3.80 | IFN-alpha-induced cortical and subcortical glutamate changes assessed by magnetic resonance spectroscopy. ( Chen, X; Haroon, E; Hu, XP; Miller, AH; Pace, TW; Parekh, S; Spivey, JR; Woolwine, BJ, 2014) |
| "Proton magnetic resonance spectroscopy analysis showed that the ratio of glutamate/glutamine to creatine (Glx/Cr) in the right hippocampus was significantly increased in patients with moderate depression and correlated positively with HAMD scores." | 3.79 | Increased ratio of glutamate/glutamine to creatine in the right hippocampus contributes to depressive symptoms in patients with epilepsy. ( Chen, CZ; Cheng, WZ; Ding, J; Fan, W; Li, X; Liang, L; Mao, LY; Peng, WF; Wang, X, 2013) |
| "The potential role of metabolic impairments in the pathophysiology of depression is motivating researchers to evaluate the treatment efficacy of creatine, a naturally occurring energetic and neuroprotective compound found in brain and muscle tissues." | 3.78 | Sex-specific antidepressant effects of dietary creatine with and without sub-acute fluoxetine in rats. ( Allen, PJ; D'Anci, KE; Kanarek, RB; Renshaw, PF, 2012) |
| "Patients with first-episode depression may have myo-inositol and phosphoric acid metabolism disorder in the thalamus and hypothalamus with malfunction of cellular osmotic pressure adjustment mechanism." | 3.75 | [Proton magnetic resonance spectroscopy of the thalamus and hypothalamus in patients with first-episode depression]. ( Bai, XY; Ning, WD; Wu, XP; Xie, ZC; Yang, JL; Yang, R, 2009) |
| "To identify possible alterations in orbitofrontal cortex levels of cytosolic choline in adolescents with and without depression, 22 depressed and 43 control adolescents were recruited." | 3.70 | Increased orbitofrontal cortex levels of choline in depressed adolescents as detected by in vivo proton magnetic resonance spectroscopy. ( Beardslee, WR; Hennen, J; Katic, A; Moore, CM; Moore, JC; Renshaw, PF; Steingard, RJ; Vakili, K; Young, AD; Yurgelun-Todd, DA, 2000) |
| "The intensity of convulsion was scored according to a seven-point scale ranging from stage 0-7." | 1.62 | Creatine attenuates seizure severity, anxiety and depressive-like behaviors in pentylenetetrazole kindled mice. ( Abiola, AL; Akhigbemen, AM; Chinazamoku, O; Igbe, I; Ogundepo, GE; Okwuofu, EO; Ozolua, RI, 2021) |
| "Creatine treatment increased PGC-1α, FNDC5 and BDNF mRNA in the hippocampus as well as BDNF immunocontent." | 1.48 | Subchronic administration of creatine produces antidepressant-like effect by modulating hippocampal signaling pathway mediated by FNDC5/BDNF/Akt in mice. ( Cunha, MP; Lieberknecht, V; Pazini, FL; Rodrigues, ALS, 2018) |
| "Markers of nocturnal hypoxemia and SDB are associated with cerebral oxidative stress in older people at-risk for dementia, suggesting a potential mechanism by which SDB may contribute to brain degeneration, cognitive decline, and dementia." | 1.43 | Association of Anterior Cingulate Glutathione with Sleep Apnea in Older Adults At-Risk for Dementia. ( Cross, N; Duffy, SL; Grunstein, R; Hermens, DF; Hickie, IB; Lagopoulos, J; Lewis, SJ; Mowszowski, L; Naismith, SL; Terpening, Z, 2016) |
| "Creatine is an antioxidant, neuromodulator and key regulator of energy metabolism shown to improve depressive symptoms in humans and animals, especially in females." | 1.42 | Chronic high-dose creatine has opposing effects on depression-related gene expression and behavior in intact and sex hormone-treated gonadectomized male and female rats. ( Allen, PJ; DeBold, JF; Kanarek, RB; Rios, M, 2015) |
| "Major depression is common in older adults and associated with greater health care utilisation and increased risk of poor health outcomes." | 1.42 | Oxidative stress and depressive symptoms in older adults: A magnetic resonance spectroscopy study. ( Cockayne, N; Duffy, SL; Hermens, DF; Hickie, IB; Lagopoulos, J; Naismith, SL, 2015) |
| "Agitation and depression are among the commonest behavioural and psychological symptoms exhibited by Alzheimer's disease patients." | 1.39 | Differences in brain metabolism associated with agitation and depression in Alzheimer's disease. ( Fuh, JL; Hung, CW; Lirng, JF; Tsai, CF; Wang, SJ, 2013) |
| "Creatine was previously shown to produce an antidepressant-like effect in the tail suspension test through a modulation of the dopaminergic system." | 1.39 | Evidence for the involvement of 5-HT1A receptor in the acute antidepressant-like effect of creatine in mice. ( Cunha, MP; Machado, DG; Oliveira, Á; Pazini, FL; Rodrigues, AL, 2013) |
| "Creatine has been shown to play a significant role in health and disease." | 1.38 | Antidepressant-like effect of creatine in mice involves dopaminergic activation. ( Bettio, LE; Capra, JC; Cunha, MP; Jacinto, J; Machado, DG; Rodrigues, AL, 2012) |
| "Moreover, depression was significantly correlated with titers of autoantibodies against DNA, NMDA receptors and cardiolipin." | 1.35 | Depression is an early disease manifestation in lupus-prone MRL/lpr mice. ( Campbell, SR; Cui, MH; Gao, HX; Gulinello, M; Hee-Hwang, J; Putterman, C; Zong, P, 2009) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 5 (9.43) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 10 (18.87) | 29.6817 |
| 2010's | 30 (56.60) | 24.3611 |
| 2020's | 8 (15.09) | 2.80 |
| Authors | Studies |
|---|---|
| Faulkner, P | 1 |
| Paioni, SL | 1 |
| Kozhuharova, P | 1 |
| Orlov, N | 1 |
| Lythgoe, DJ | 1 |
| Daniju, Y | 1 |
| Morgenroth, E | 1 |
| Barker, H | 1 |
| Allen, P | 1 |
| Xie, T | 1 |
| Li, R | 1 |
| Long, X | 1 |
| Chen, J | 1 |
| Ye, L | 1 |
| Wang, J | 2 |
| Jiang, G | 1 |
| Lv, J | 1 |
| Abdulla, ZI | 1 |
| Pennington, JL | 1 |
| Gutierrez, A | 1 |
| Skelton, MR | 1 |
| Bakian, AV | 1 |
| Huber, RS | 1 |
| Scholl, L | 1 |
| Renshaw, PF | 4 |
| Kondo, D | 1 |
| Zhou, T | 1 |
| Liu, J | 1 |
| Shangguan, J | 1 |
| Liu, X | 1 |
| Li, Z | 1 |
| Zhou, X | 1 |
| Ren, Y | 1 |
| Wang, C | 1 |
| Kim, S | 2 |
| Hong, KB | 1 |
| Suh, HJ | 1 |
| Jo, K | 1 |
| Smith, GS | 1 |
| Oeltzschner, G | 1 |
| Gould, NF | 1 |
| Leoutsakos, JS | 1 |
| Nassery, N | 1 |
| Joo, JH | 1 |
| Kraut, MA | 1 |
| Edden, RAE | 1 |
| Barker, PB | 1 |
| Wijtenburg, SA | 1 |
| Rowland, LM | 1 |
| Workman, CI | 1 |
| Okwuofu, EO | 1 |
| Ogundepo, GE | 1 |
| Akhigbemen, AM | 1 |
| Abiola, AL | 1 |
| Ozolua, RI | 1 |
| Igbe, I | 1 |
| Chinazamoku, O | 1 |
| Urrila, AS | 1 |
| Hakkarainen, A | 1 |
| Castaneda, A | 1 |
| Paunio, T | 1 |
| Marttunen, M | 1 |
| Lundbom, N | 1 |
| Freed, RD | 1 |
| Hollenhorst, CN | 1 |
| Weiduschat, N | 1 |
| Mao, X | 1 |
| Kang, G | 1 |
| Shungu, DC | 1 |
| Gabbay, V | 1 |
| Cunha, MP | 8 |
| Pazini, FL | 7 |
| Lieberknecht, V | 3 |
| Rodrigues, ALS | 2 |
| Mellen, EJ | 1 |
| Harper, DG | 1 |
| Ravichandran, C | 1 |
| Jensen, E | 1 |
| Silveri, M | 1 |
| Forester, BP | 1 |
| Demartini, B | 1 |
| Gambini, O | 1 |
| Uggetti, C | 1 |
| Cariati, M | 1 |
| Cadioli, M | 1 |
| Goeta, D | 1 |
| Marceglia, S | 1 |
| Ferrucci, R | 1 |
| Priori, A | 1 |
| Muelly, ER | 1 |
| Moore, GJ | 1 |
| Bunce, SC | 1 |
| Mack, J | 1 |
| Bigler, DC | 1 |
| Morton, DH | 1 |
| Strauss, KA | 1 |
| Ezzati, A | 1 |
| Zimmerman, ME | 1 |
| Katz, MJ | 1 |
| Lipton, RB | 1 |
| Peng, WF | 1 |
| Ding, J | 1 |
| Mao, LY | 1 |
| Li, X | 1 |
| Liang, L | 1 |
| Chen, CZ | 1 |
| Cheng, WZ | 1 |
| Fan, W | 1 |
| Wang, X | 2 |
| Chamard, E | 1 |
| Henry, L | 1 |
| Boulanger, Y | 1 |
| Lassonde, M | 1 |
| Théoret, H | 1 |
| Tsai, CF | 1 |
| Hung, CW | 1 |
| Lirng, JF | 1 |
| Wang, SJ | 1 |
| Fuh, JL | 1 |
| Haroon, E | 1 |
| Woolwine, BJ | 1 |
| Chen, X | 1 |
| Pace, TW | 1 |
| Parekh, S | 1 |
| Spivey, JR | 1 |
| Hu, XP | 1 |
| Miller, AH | 1 |
| Ludka, FK | 1 |
| Rosa, JM | 5 |
| Oliveira, Á | 5 |
| Budni, J | 1 |
| Ramos-Hryb, AB | 3 |
| Bettio, LE | 3 |
| Martín-de-Saavedra, MD | 1 |
| López, MG | 1 |
| Tasca, CI | 1 |
| Rodrigues, AL | 6 |
| Allen, PJ | 3 |
| DeBold, JF | 1 |
| Rios, M | 1 |
| Kanarek, RB | 3 |
| Kaster, MP | 1 |
| Duffy, SL | 2 |
| Lagopoulos, J | 2 |
| Cockayne, N | 1 |
| Hermens, DF | 2 |
| Hickie, IB | 2 |
| Naismith, SL | 2 |
| Colla, AR | 1 |
| Terpening, Z | 1 |
| Lewis, SJ | 1 |
| Grunstein, R | 1 |
| Mowszowski, L | 1 |
| Cross, N | 1 |
| Azevedo, D | 1 |
| Colla, A | 1 |
| de Oliveira, J | 1 |
| Brocardo, PS | 1 |
| Gil-Mohapel, J | 1 |
| Zhang, L | 2 |
| Sui, R | 1 |
| Zhang, Z | 2 |
| Kantorová, E | 1 |
| Poláček, H | 1 |
| Bittšanský, M | 2 |
| Baranovičová, E | 1 |
| Hnilicová, P | 1 |
| Čierny, D | 1 |
| Sivák, Š | 1 |
| Nosáľ, V | 1 |
| Zeleňák, K | 1 |
| Kurča, E | 1 |
| Gao, HX | 1 |
| Campbell, SR | 1 |
| Cui, MH | 1 |
| Zong, P | 1 |
| Hee-Hwang, J | 1 |
| Gulinello, M | 1 |
| Putterman, C | 1 |
| Duan, DM | 1 |
| Tu, Y | 1 |
| Chen, LP | 1 |
| Wu, ZJ | 1 |
| D'Anci, KE | 2 |
| Yang, R | 1 |
| Wu, XP | 1 |
| Bai, XY | 1 |
| Ning, WD | 1 |
| Yang, JL | 1 |
| Xie, ZC | 1 |
| Valdés, M | 1 |
| Collado, A | 1 |
| Bargalló, N | 1 |
| Vázquez, M | 1 |
| Rami, L | 1 |
| Gómez, E | 1 |
| Salamero, M | 1 |
| Bédard, MJ | 1 |
| Chantal, S | 1 |
| Li, YH | 1 |
| Li, MH | 1 |
| Lu, J | 1 |
| Zhao, JG | 1 |
| Sun, XJ | 1 |
| Zhang, B | 1 |
| Ye, JL | 1 |
| Xi, G | 1 |
| Hui, J | 1 |
| Liu, S | 1 |
| Zhang, X | 1 |
| Teng, G | 1 |
| Chan, KC | 1 |
| Wu, EX | 1 |
| Nie, B | 1 |
| Shan, B | 1 |
| Li, L | 1 |
| Reynolds, GP | 1 |
| Husarova, V | 1 |
| Ondrejka, I | 1 |
| Kerna, V | 1 |
| Dobrota, D | 1 |
| Machado, DG | 3 |
| Capra, JC | 1 |
| Jacinto, J | 1 |
| Gruber, S | 1 |
| Frey, R | 1 |
| Mlynárik, V | 1 |
| Stadlbauer, A | 1 |
| Heiden, A | 1 |
| Kasper, S | 1 |
| Kemp, GJ | 1 |
| Moser, E | 1 |
| OYEN, I | 1 |
| BOYLAN, JW | 1 |
| PRYCE, IG | 1 |
| Kleefstra, T | 1 |
| Rosenberg, EH | 1 |
| Salomons, GS | 1 |
| Stroink, H | 1 |
| van Bokhoven, H | 1 |
| Hamel, BC | 1 |
| de Vries, BB | 1 |
| Gonul, AS | 1 |
| Kitis, O | 1 |
| Ozan, E | 1 |
| Akdeniz, F | 1 |
| Eker, C | 1 |
| Eker, OD | 1 |
| Vahip, S | 1 |
| Crawford, B | 1 |
| Gilliam, FG | 1 |
| Maton, BM | 1 |
| Martin, RC | 1 |
| Sawrie, SM | 1 |
| Faught, RE | 1 |
| Hugg, JW | 1 |
| Viikinsalo, M | 1 |
| Kuzniecky, RI | 1 |
| Hong, ST | 1 |
| Choi, CB | 1 |
| Park, C | 1 |
| Hong, KS | 1 |
| Cheong, C | 1 |
| Jeon, YW | 1 |
| Choe, BY | 1 |
| Mu, J | 1 |
| Xie, P | 1 |
| Yang, ZS | 1 |
| Yang, DL | 1 |
| Lv, FJ | 1 |
| Luo, TY | 1 |
| Li, Y | 1 |
| Bertolini, AM | 1 |
| Santagostino, A | 1 |
| Steingard, RJ | 1 |
| Yurgelun-Todd, DA | 1 |
| Hennen, J | 1 |
| Moore, JC | 1 |
| Moore, CM | 1 |
| Vakili, K | 1 |
| Young, AD | 1 |
| Katic, A | 1 |
| Beardslee, WR | 1 |
| McNamee, HB | 1 |
| Moody, JP | 1 |
| Naylor, GJ | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| The Effect of Creatine Monohydrate on Persistent Post-concussive Symptoms - a Pilot Study Protocol[NCT05562232] | 45 participants (Anticipated) | Interventional | 2022-10-01 | Not yet recruiting | |||
| Creatine Augmentation in Female & Male Veterans With Selective Serotonin Reuptake Inhibitor-Resistant Major Depressive Disorder[NCT01175616] | Phase 4 | 0 participants (Actual) | Interventional | 2012-09-30 | Withdrawn (stopped due to Study withdrawn from ClinicalTrials.gov.) | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
2 trials available for creatine and Depression
| Article | Year |
|---|---|
[Study on electroacupuncture treatment of depression by magnetic resonance imaging].
Topics: Adult; Choline; Creatine; Depression; Electroacupuncture; Female; Frontal Lobe; Hippocampus; Humans; | 2009 |
The effect of antidepressant treatment on N-acetyl aspartate levels of medial frontal cortex in drug-free depressed patients.
Topics: Adult; Analysis of Variance; Antidepressive Agents; Aspartic Acid; Brain Mapping; Choline; Creatine; | 2006 |
51 other studies available for creatine and Depression
| Article | Year |
|---|---|
Relationship between depression, prefrontal creatine and grey matter volume.
Topics: Adolescent; Adult; Creatine; Depression; Female; Gray Matter; Humans; Magnetic Resonance Imaging; Ma | 2021 |
Magnetic resonance imaging features of hippocampus and mechanism of neurocognitive dysfunction for antiepileptic drugs in treatment of depression rats.
Topics: Animals; Anticonvulsants; Aspartic Acid; Creatine; Depression; Hippocampus; Magnetic Resonance Imagi | 2022 |
Creatine transporter knockout mice (Slc6a8) show increases in serotonin-related proteins and are resilient to learned helplessness.
Topics: Animals; Anxiety; Behavior, Animal; Corpus Striatum; Creatine; Depression; Disease Models, Animal; E | 2020 |
Dietary creatine intake and depression risk among U.S. adults.
Topics: Adult; Creatine; Cross-Sectional Studies; Depression; Diet; Female; Humans; Nutrition Surveys | 2020 |
Application of
Topics: Adult; Aspartic Acid; Choline; Creatine; Depression; Female; Frontal Lobe; Humans; Kidney Failure, C | 2020 |
Creatine and taurine mixtures alleviate depressive-like behaviour in Drosophila melanogaster and mice via regulating Akt and ERK/BDNF pathways.
Topics: Animals; Antidepressive Agents; Behavior, Animal; Brain-Derived Neurotrophic Factor; Catecholamines; | 2020 |
Neurotransmitters and Neurometabolites in Late-Life Depression: A Preliminary Magnetic Resonance Spectroscopy Study at 7T.
Topics: Aspartic Acid; Creatine; Depression; Depressive Disorder, Major; Glutamic Acid; Gyrus Cinguli; Human | 2021 |
Creatine attenuates seizure severity, anxiety and depressive-like behaviors in pentylenetetrazole kindled mice.
Topics: Animals; Anxiety; Convulsants; Creatine; Depression; Dose-Response Relationship, Drug; Glutathione; | 2021 |
Frontal Cortex Myo-Inositol Is Associated with Sleep and Depression in Adolescents: A Proton Magnetic Resonance Spectroscopy Study.
Topics: Adolescent; Aspartic Acid; Creatine; Depression; Female; Frontal Lobe; Humans; Image Processing, Com | 2017 |
A pilot study of cortical glutathione in youth with depression.
Topics: Adolescent; Anhedonia; Aspartic Acid; Case-Control Studies; Child; Choline; Creatine; Depression; De | 2017 |
Subchronic administration of creatine produces antidepressant-like effect by modulating hippocampal signaling pathway mediated by FNDC5/BDNF/Akt in mice.
Topics: Animals; Antidepressive Agents; bcl-2-Associated X Protein; Brain-Derived Neurotrophic Factor; Creat | 2018 |
Lamotrigine Therapy and Biomarkers of Cerebral Energy Metabolism in Older Age Bipolar Depression.
Topics: Aged; Aging; Antipsychotic Agents; Aspartic Acid; Biomarkers; Bipolar Disorder; Cerebral Cortex; Cre | 2019 |
Limbic neurochemical changes in patients with functional motor symptoms.
Topics: Adult; Affective Symptoms; Anxiety; Case-Control Studies; Creatine; Depression; Female; Glutamic Aci | 2019 |
Biochemical correlates of neuropsychiatric illness in maple syrup urine disease.
Topics: Adolescent; Adult; Affect; Anxiety; Aspartic Acid; Attention; Brain; Case-Control Studies; Child; Ch | 2013 |
Hippocampal correlates of depression in healthy elderly adults.
Topics: Aged; Aged, 80 and over; Aspartic Acid; Creatine; Depression; Female; Geriatrics; Hippocampus; Human | 2013 |
Increased ratio of glutamate/glutamine to creatine in the right hippocampus contributes to depressive symptoms in patients with epilepsy.
Topics: Adolescent; Adult; Creatine; Depression; Epilepsy; Female; Functional Laterality; Glutamic Acid; Glu | 2013 |
A follow-up study of neurometabolic alterations in female concussed athletes.
Topics: Aspartic Acid; Athletes; Athletic Injuries; Brain Chemistry; Brain Concussion; Creatine; Depression; | 2014 |
Differences in brain metabolism associated with agitation and depression in Alzheimer's disease.
Topics: Aged; Alzheimer Disease; Aspartic Acid; Choline; Creatine; Depression; Female; Gyrus Cinguli; Humans | 2013 |
IFN-alpha-induced cortical and subcortical glutamate changes assessed by magnetic resonance spectroscopy.
Topics: Adult; Aged; Antiviral Agents; Brain; Creatine; Cytokines; Depression; Female; Glutamic Acid; Hepaci | 2014 |
The modulation of NMDA receptors and L-arginine/nitric oxide pathway is implicated in the anti-immobility effect of creatine in the tail suspension test.
Topics: Animals; Antidepressive Agents; Arginine; Creatine; Depression; Female; Hindlimb Suspension; Humans; | 2015 |
Chronic high-dose creatine has opposing effects on depression-related gene expression and behavior in intact and sex hormone-treated gonadectomized male and female rats.
Topics: Animals; Behavior, Animal; Creatine; Depression; Doublecortin Protein; Drug Synergism; Estradiol; Fe | 2015 |
Creatine, similarly to ketamine, affords antidepressant-like effects in the tail suspension test via adenosine A₁ and A2A receptor activation.
Topics: Adenosine; Animals; Antidepressive Agents; Creatine; Depression; Excitatory Amino Acid Antagonists; | 2015 |
Oxidative stress and depressive symptoms in older adults: A magnetic resonance spectroscopy study.
Topics: Aged; Aged, 80 and over; Brain; Creatine; Depression; Depressive Disorder, Major; Female; Glutathion | 2015 |
Creatine, Similar to Ketamine, Counteracts Depressive-Like Behavior Induced by Corticosterone via PI3K/Akt/mTOR Pathway.
Topics: Animals; Antidepressive Agents; Behavior, Animal; Brain-Derived Neurotrophic Factor; Corticosterone; | 2016 |
Association of Anterior Cingulate Glutathione with Sleep Apnea in Older Adults At-Risk for Dementia.
Topics: Aged; Aging; Biomarkers; Cognition Disorders; Cognitive Dysfunction; Creatine; Dementia; Depression; | 2016 |
Creatine Prevents Corticosterone-Induced Reduction in Hippocampal Proliferation and Differentiation: Possible Implication for Its Antidepressant Effect.
Topics: Animals; Antidepressive Agents; Behavior, Animal; Cell Differentiation; Cell Proliferation; Corticos | 2017 |
Morphological and Metabolic Alteration of Cerebellum in Patients with Post-Stroke Depression.
Topics: Anisotropy; Case-Control Studies; Cerebellum; Choline; Creatine; Depression; Female; Humans; Magneti | 2016 |
Hypothalamic damage in multiple sclerosis correlates with disease activity, disability, depression, and fatigue.
Topics: Adult; Aging; Aspartic Acid; Case-Control Studies; Choline; Creatine; Cross-Sectional Studies; Depre | 2017 |
Depression is an early disease manifestation in lupus-prone MRL/lpr mice.
Topics: Animals; Aspartic Acid; Autoantibodies; Brain; Cardiolipins; Choline; Chromatin; Creatine; Depressio | 2009 |
Chronic creatine supplementation alters depression-like behavior in rodents in a sex-dependent manner.
Topics: Analysis of Variance; Animals; Antidepressive Agents; Body Temperature; Creatine; Depression; Diseas | 2010 |
[Proton magnetic resonance spectroscopy of the thalamus and hypothalamus in patients with first-episode depression].
Topics: Adolescent; Adult; Case-Control Studies; Choline; Creatine; Depression; Female; Humans; Hypothalamus | 2009 |
Increased glutamate/glutamine compounds in the brains of patients with fibromyalgia: a magnetic resonance spectroscopy study.
Topics: Anxiety; Brain; Brain Mapping; Chi-Square Distribution; Creatine; Depression; Female; Fibromyalgia; | 2010 |
Brain magnetic resonance spectroscopy in obsessive-compulsive disorder: the importance of considering subclinical symptoms of anxiety and depression.
Topics: Adult; Anxiety; Aspartic Acid; Brain; Brain Mapping; Choline; Creatine; Depression; Female; Function | 2011 |
Glutamate level detection by magnetic resonance spectroscopy in patients with post-stroke depression.
Topics: Aged; Aspartic Acid; Brain; Brain Mapping; Creatine; Depression; Female; Glutamic Acid; Humans; Inos | 2012 |
Learning and memory alterations are associated with hippocampal N-acetylaspartate in a rat model of depression as measured by 1H-MRS.
Topics: Animals; Aspartic Acid; Behavior, Animal; Citalopram; Creatine; Depression; Disease Models, Animal; | 2011 |
Sex-specific antidepressant effects of dietary creatine with and without sub-acute fluoxetine in rats.
Topics: Animals; Antidepressive Agents; Behavior, Animal; Brain; Creatine; Depression; Dietary Supplements; | 2012 |
Hippocampal neurometabolite changes in depression treatment: a (1)H magnetic resonance spectroscopy study.
Topics: Adult; Antidepressive Agents; Aspartic Acid; Choline; Creatine; Depression; Female; Functional Later | 2012 |
Antidepressant-like effect of creatine in mice involves dopaminergic activation.
Topics: Animals; Antidepressive Agents; Creatine; Depression; Disease Models, Animal; Dopamine; Dopamine Ago | 2012 |
Evidence for the involvement of 5-HT1A receptor in the acute antidepressant-like effect of creatine in mice.
Topics: Animals; Antidepressive Agents; Creatine; Depression; Depressive Disorder; Hindlimb Suspension; Huma | 2013 |
The activation of α1-adrenoceptors is implicated in the antidepressant-like effect of creatine in the tail suspension test.
Topics: Adrenergic Agents; alpha-Methyltyrosine; Analysis of Variance; Animals; Antidepressive Agents; Creat | 2013 |
Quantification of metabolic differences in the frontal brain of depressive patients and controls obtained by 1H-MRS at 3 Tesla.
Topics: Adult; Antidepressive Agents; Aspartic Acid; Case-Control Studies; Choline; Creatine; Depression; Fe | 2003 |
Renal clearance in the unanesthetized guinea pig: depression of inulin clearance by creatinine.
Topics: Creatine; Creatinine; Depression; Depressive Disorder; Guinea Pigs; Inulin; Kidney Function Tests | 1962 |
THE RELATIONSHIP BETWEEN 17-HYDROXYCORTICOSTEROID EXCRETION AND GLUCOSE UTILIZATION IN DEPRESSIONS.
Topics: 17-Hydroxycorticosteroids; Adrenal Cortex Hormones; Blood Glucose; Body Weight; Carbohydrate Metabol | 1964 |
Progressive intestinal, neurological and psychiatric problems in two adult males with cerebral creatine deficiency caused by an SLC6A8 mutation.
Topics: Aged; Amino Acid Transport Disorders, Inborn; Brain; Creatine; Depression; Disease Progression; Fema | 2005 |
DEPRESSION OF THE EXOGENOUS CREATININE/INULIN OR THIOSULFATE CLEARANCE RATIOS IN MAN BY DIODRAST AND p-AMINOHIPPURIC ACID.
Topics: Creatine; Creatinine; Depression; Humans; Inulin; Iodopyracet; p-Aminohippuric Acid; Thiosulfates | 1948 |
Hippocampal 1H-MRSI correlates with severity of depression symptoms in temporal lobe epilepsy.
Topics: Adult; Aspartic Acid; Biomarkers; Creatine; Depression; Epilepsy, Temporal Lobe; Female; Hippocampus | 2007 |
Variation of the choline signal intensity in the dorsolateral prefrontal cortex of rats exposed to the forced swimming test as detected by in vivo 1H MR spectroscopy.
Topics: Animals; Aspartic Acid; Choline; Creatine; Depression; Magnetic Resonance Spectroscopy; Male; Prefro | 2007 |
1H magnetic resonance spectroscopy study of thalamus in treatment resistant depressive patients.
Topics: Adult; Aspartic Acid; Choline; Creatine; Depression; Female; Humans; Magnetic Resonance Spectroscopy | 2007 |
[Deficiency of amino acid precursors of chemical mediators and of creatine in the aged].
Topics: Acetylcholine; Aged; Aging; Amino Acids; Creatine; Depression; Histamine; Humans; Nicotinic Acids; S | 1981 |
Increased orbitofrontal cortex levels of choline in depressed adolescents as detected by in vivo proton magnetic resonance spectroscopy.
Topics: Adolescent; Aspartic Acid; Case-Control Studies; Choline; Creatine; Cytosol; Depression; Female; Fro | 2000 |
Indoleamine metabolism in affective disorders: excretion of tryptamine, indoleacetic acid and 5-hydroxy-indoleacetic acid in depressive states.
Topics: Adult; Affective Symptoms; Aged; Creatine; Depression; Female; Humans; Hydroxyindoleacetic Acid; Ind | 1972 |