creatine has been researched along with Depression, Involutional in 62 studies
Depression, Involutional: Form of depression in those MIDDLE AGE with feelings of ANXIETY.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Altered brain creatine-phosphocreatine levels might reflect changes in brain energy use and have been implicated in the pathogenesis of obsessive-compulsive disorder and major depressive disorder." | 7.73 | Increased medial thalamic creatine-phosphocreatine found by proton magnetic resonance spectroscopy in children with obsessive-compulsive disorder versus major depression and healthy controls. ( Banerjee, SP; Bhandari, R; Boyd, C; Ivey, J; Mirza, Y; O'Neill, J; Renshaw, PF; Rose, M; Rosenberg, DR; Russell, A; Smith, EA; Smith, JM, 2006) |
| "Adolescent major depressive disorder (MDD) is a life-threatening brain disease with limited interventions." | 6.76 | Open-label adjunctive creatine for female adolescents with SSRI-resistant major depressive disorder: a 31-phosphorus magnetic resonance spectroscopy study. ( Fiedler, KK; Hellem, TL; Jeong, EK; Kondo, DG; Renshaw, PF; Shi, X; Sung, YH, 2011) |
| "Altered brain creatine-phosphocreatine levels might reflect changes in brain energy use and have been implicated in the pathogenesis of obsessive-compulsive disorder and major depressive disorder." | 3.73 | Increased medial thalamic creatine-phosphocreatine found by proton magnetic resonance spectroscopy in children with obsessive-compulsive disorder versus major depression and healthy controls. ( Banerjee, SP; Bhandari, R; Boyd, C; Ivey, J; Mirza, Y; O'Neill, J; Renshaw, PF; Rose, M; Rosenberg, DR; Russell, A; Smith, EA; Smith, JM, 2006) |
| "Fifty-two women with major depressive disorder were enrolled in an 8-week double-blind placebo-controlled clinical trial and randomly assigned to receive escitalopram in addition to either creatine (5 g/day, N=25) or placebo (N=27)." | 2.77 | A randomized, double-blind placebo-controlled trial of oral creatine monohydrate augmentation for enhanced response to a selective serotonin reuptake inhibitor in women with major depressive disorder. ( Bae, S; Hwang, J; Kim, JE; Kim, TS; Lyoo, IK; Renshaw, PF; Won, W; Yoon, S, 2012) |
| "Adolescent major depressive disorder (MDD) is a life-threatening brain disease with limited interventions." | 2.76 | Open-label adjunctive creatine for female adolescents with SSRI-resistant major depressive disorder: a 31-phosphorus magnetic resonance spectroscopy study. ( Fiedler, KK; Hellem, TL; Jeong, EK; Kondo, DG; Renshaw, PF; Shi, X; Sung, YH, 2011) |
| "Symptoms of GAD overlap with those of major depressive disorder to such an extent that studying one disorder without studying the other may be impossible." | 2.45 | Neurobiology of generalized anxiety disorder. ( Stein, MB, 2009) |
| "Obsessive-compulsive disorder (OCD) and major depressive disorder (MDD) both showed cognitive impairment, and the altered neurometabolic may associate with cognitive impairment." | 1.72 | Similarities and differences in working memory and neurometabolism of obsessive-compulsive disorder and major depressive disorder. ( Chen, G; Chen, P; He, J; Jia, Y; Lai, S; Lu, Q; Song, Z; Wang, Y; Yan, S; Zhang, Y; Zhao, H; Zhong, S, 2022) |
| "Rates of major depressive disorder (MDD) increase with living at altitude." | 1.62 | Sex-Based Impact of Creatine Supplementation on Depressive Symptoms, Brain Serotonin and SSRI Efficacy in an Animal Model of Treatment-Resistant Depression. ( Brown, J; Ettaro, R; Hoffman, MD; Kanekar, S; Lynch, C; Ombach, HJ; Renshaw, PF; Sheth, CS, 2021) |
| "Despite the high incidence of major depressive disorder (MDD) in females, the detailed neurobiology mechanism remains not fully understood." | 1.48 | Left fimbria atrophy is associated with hippocampal metabolism in female major depressive disorder patients. ( Cecilio Baro, C; Li, Y; Meng, Z; Tang, Y; Xu, J; Zhang, X, 2018) |
| "Major depression is common in older adults and associated with greater health care utilisation and increased risk of poor health outcomes." | 1.42 | Oxidative stress and depressive symptoms in older adults: A magnetic resonance spectroscopy study. ( Cockayne, N; Duffy, SL; Hermens, DF; Hickie, IB; Lagopoulos, J; Naismith, SL, 2015) |
| "Insomnia is closely related to major depressive disorder (MDD) both cross-sectionally and longitudinally, and as such, offers potential opportunities to refine our understanding of the neurobiology of both sleep and mood disorders." | 1.38 | Reduced γ-aminobutyric acid in occipital and anterior cingulate cortices in primary insomnia: a link to major depressive disorder? ( Jensen, JE; Plante, DT; Schoerning, L; Winkelman, JW, 2012) |
| "Seventy-five elderly patients with major depressive disorder in remission underwent assessment of insight using the Mood Disorders Insight Scale (MDIS), including awareness, attribution, and need for treatment." | 1.36 | Brain proton magnetic resonance spectroscopic study of insight among elders with late-life depression in remission. ( Chang, HC; Chen, CS; Ko, CH; Kuo, YT; Li, CW; Lin, HF; Liu, GC; Yeh, YC; Yen, CF, 2010) |
| "Patients with late-life major depressive disorder had a significantly lower NAA/creatine ratio in the left frontal white matter, and higher Cho/creatine and myo-inositol/creatine ratios in the left basal ganglia when compared with the control subjects." | 1.35 | Proton magnetic resonance spectroscopy of late-life major depressive disorder. ( Chen, CS; Chiang, IC; Hsieh, TJ; Kuo, YT; Li, CW; Lin, HF; Lin, WC; Liu, GC; Lu, CY, 2009) |
| "Co-morbidities of PTSD, notably alcohol abuse, may have contributed to the inconsistency." | 1.35 | Abnormal N-acetylaspartate in hippocampus and anterior cingulate in posttraumatic stress disorder. ( Fox-Bosetti, S; Kornak, J; Lenoci, M; Marmar, CR; Neylan, TC; Samuelson, KW; Schuff, N; Studholme, C; Weiner, MW, 2008) |
| "Patients with type 2 diabetes and major depression (n=20) were scanned along with patients with diabetes alone (n=24) and healthy controls (n=21) on a 1." | 1.34 | Measurement of brain metabolites in patients with type 2 diabetes and major depression using proton magnetic resonance spectroscopy. ( Ajilore, O; Binesh, N; Darwin, C; Haroon, E; Kumar, A; Kumaran, S; Miller, J; Mintz, J; Thomas, MA, 2007) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 25 (40.32) | 29.6817 |
| 2010's | 26 (41.94) | 24.3611 |
| 2020's | 11 (17.74) | 2.80 |
| Authors | Studies |
|---|---|
| Lv, S | 2 |
| Zhong, S | 9 |
| Zhang, S | 1 |
| Lai, S | 7 |
| Wang, Y | 10 |
| Zhao, H | 5 |
| Zhang, Y | 5 |
| Luo, Y | 2 |
| Yan, S | 3 |
| Ran, H | 2 |
| Chen, P | 5 |
| Chen, G | 4 |
| Jia, Y | 11 |
| Wu, W | 1 |
| He, J | 3 |
| Zhu, Y | 2 |
| Qi, Z | 1 |
| Song, Z | 3 |
| Hu, Y | 1 |
| Miao, H | 2 |
| Huang, X | 2 |
| Lu, X | 2 |
| Liu, X | 1 |
| Lu, Q | 2 |
| Yang, H | 1 |
| Tran, KH | 1 |
| Luki, J | 1 |
| Hanstock, S | 1 |
| Hanstock, CC | 2 |
| Seres, P | 2 |
| Aitchison, K | 1 |
| Shandro, T | 1 |
| Le Melledo, JM | 1 |
| Ye, K | 1 |
| Duan, M | 1 |
| Song, K | 1 |
| Kious, BM | 1 |
| Kondo, DG | 3 |
| Renshaw, PF | 7 |
| Güleş, E | 1 |
| Iosifescu, DV | 1 |
| Tural, Ü | 1 |
| Kahl, KG | 1 |
| Atalay, S | 1 |
| Maudsley, AA | 1 |
| Sheriff, S | 1 |
| Cummings, A | 1 |
| Frieling, H | 1 |
| Schmitz, B | 1 |
| Lanfermann, H | 1 |
| Ding, XQ | 1 |
| Smith, GS | 1 |
| Oeltzschner, G | 1 |
| Gould, NF | 1 |
| Leoutsakos, JS | 1 |
| Nassery, N | 1 |
| Joo, JH | 1 |
| Kraut, MA | 1 |
| Edden, RAE | 1 |
| Barker, PB | 2 |
| Wijtenburg, SA | 1 |
| Rowland, LM | 1 |
| Workman, CI | 1 |
| Kanekar, S | 1 |
| Ettaro, R | 1 |
| Hoffman, MD | 1 |
| Ombach, HJ | 1 |
| Brown, J | 1 |
| Lynch, C | 1 |
| Sheth, CS | 1 |
| Freed, RD | 1 |
| Hollenhorst, CN | 1 |
| Weiduschat, N | 1 |
| Mao, X | 2 |
| Kang, G | 2 |
| Shungu, DC | 2 |
| Gabbay, V | 3 |
| Shan, Y | 1 |
| Li, X | 1 |
| Chen, J | 1 |
| Zhang, L | 1 |
| Li, Z | 1 |
| Xu, J | 1 |
| Tang, Y | 1 |
| Cecilio Baro, C | 1 |
| Zhang, X | 1 |
| Meng, Z | 1 |
| Li, Y | 1 |
| Nemets, B | 1 |
| Levine, J | 2 |
| Tae, WS | 1 |
| Kim, SS | 1 |
| Lee, KU | 1 |
| Nam, EC | 1 |
| Koh, SH | 1 |
| Shi, XF | 1 |
| Forrest, LN | 1 |
| Kuykendall, MD | 1 |
| Prescot, AP | 1 |
| Sung, YH | 2 |
| Huber, RS | 1 |
| Hellem, TL | 2 |
| Jeong, EK | 2 |
| Zhao, G | 1 |
| Xiang, Q | 1 |
| Ling, X | 3 |
| Liu, S | 4 |
| Huang, L | 4 |
| Duffy, SL | 2 |
| Lagopoulos, J | 2 |
| Cockayne, N | 2 |
| Hermens, DF | 2 |
| Hickie, IB | 2 |
| Naismith, SL | 2 |
| Liu, T | 1 |
| Liao, X | 1 |
| Lewis, SJ | 1 |
| Bradley, KA | 1 |
| Case, JA | 1 |
| Yoon, S | 2 |
| Kim, JE | 2 |
| Hwang, J | 2 |
| Kim, TS | 2 |
| Kang, HJ | 1 |
| Namgung, E | 1 |
| Ban, S | 1 |
| Oh, S | 1 |
| Yang, J | 1 |
| Lyoo, IK | 2 |
| Demenescu, LR | 1 |
| Colic, L | 1 |
| Li, M | 1 |
| Safron, A | 1 |
| Biswal, B | 1 |
| Metzger, CD | 1 |
| Li, S | 1 |
| Walter, M | 1 |
| Tan, HZ | 1 |
| Li, H | 1 |
| Liu, CF | 1 |
| Guan, JT | 1 |
| Guo, XB | 1 |
| Wen, CH | 1 |
| Ou, SM | 1 |
| Zhang, YN | 1 |
| Zhang, J | 1 |
| Xu, CT | 1 |
| Shen, ZW | 1 |
| Wu, RH | 1 |
| Wang, XQ | 1 |
| Murck, H | 1 |
| Schubert, MI | 1 |
| Schmid, D | 1 |
| Schüssler, P | 1 |
| Steiger, A | 1 |
| Auer, DP | 2 |
| MacMaster, FP | 2 |
| Moore, GJ | 2 |
| Russell, A | 3 |
| Mirza, Y | 3 |
| Taormina, SP | 1 |
| Buhagiar, C | 1 |
| Rosenberg, DR | 3 |
| Venkatraman, TN | 1 |
| Krishnan, RR | 1 |
| Steffens, DC | 1 |
| Song, AW | 1 |
| Taylor, WD | 1 |
| Chen, CS | 2 |
| Chiang, IC | 1 |
| Li, CW | 2 |
| Lin, WC | 1 |
| Lu, CY | 1 |
| Hsieh, TJ | 1 |
| Liu, GC | 2 |
| Lin, HF | 2 |
| Kuo, YT | 2 |
| Stein, MB | 1 |
| Kaymak, SU | 1 |
| Demir, B | 1 |
| Oğuz, KK | 1 |
| Sentürk, S | 1 |
| Uluğ, B | 1 |
| Nery, FG | 1 |
| Stanley, JA | 2 |
| Chen, HH | 2 |
| Hatch, JP | 2 |
| Nicoletti, MA | 1 |
| Monkul, ES | 1 |
| Matsuo, K | 1 |
| Caetano, SC | 2 |
| Peluso, MA | 1 |
| Najt, P | 1 |
| Soares, JC | 2 |
| Rao, V | 1 |
| Munro, CA | 1 |
| Rosenberg, P | 1 |
| Ward, J | 1 |
| Bertrand, M | 1 |
| Degoankar, M | 1 |
| Horská, A | 1 |
| Pham, D | 1 |
| Yousem, DM | 1 |
| Ko, CH | 1 |
| Yeh, YC | 1 |
| Chang, HC | 1 |
| Yen, CF | 1 |
| Olvera, RL | 1 |
| Nicoletti, M | 1 |
| Fonseca, M | 1 |
| Pliszka, SR | 1 |
| Merkl, A | 1 |
| Schubert, F | 1 |
| Quante, A | 1 |
| Luborzewski, A | 1 |
| Brakemeier, EL | 1 |
| Grimm, S | 1 |
| Heuser, I | 1 |
| Bajbouj, M | 1 |
| Fiedler, KK | 1 |
| Shi, X | 1 |
| Xu, G | 2 |
| Zheng, P | 1 |
| Gao, HC | 1 |
| Li, Q | 1 |
| Shao, WH | 1 |
| Zhang, ML | 1 |
| Cheng, K | 1 |
| Yang, DY | 1 |
| Fan, SH | 1 |
| Chen, L | 1 |
| Fang, L | 1 |
| Xie, P | 1 |
| Plante, DT | 1 |
| Jensen, JE | 1 |
| Schoerning, L | 1 |
| Winkelman, JW | 1 |
| Chen, X | 1 |
| Won, W | 1 |
| Bae, S | 1 |
| Strakowski, SM | 1 |
| Obergriesser, T | 1 |
| Ende, G | 2 |
| Braus, DF | 1 |
| Henn, FA | 2 |
| Vythilingam, M | 1 |
| Charles, HC | 1 |
| Tupler, LA | 1 |
| Blitchington, T | 1 |
| Kelly, L | 1 |
| Krishnan, KR | 1 |
| Wood, SJ | 1 |
| Berger, G | 1 |
| Velakoulis, D | 1 |
| Phillips, LJ | 1 |
| McGorry, PD | 1 |
| Yung, AR | 1 |
| Desmond, P | 1 |
| Pantelis, C | 1 |
| Blasi, G | 1 |
| Bertolino, A | 1 |
| Brudaglio, F | 1 |
| Sciota, D | 1 |
| Altamura, M | 1 |
| Antonucci, N | 1 |
| Scarabino, T | 1 |
| Weinberger, DR | 1 |
| Nardini, M | 1 |
| Tang, J | 1 |
| Smith, JM | 2 |
| Banerjee, SP | 2 |
| Bhandari, R | 2 |
| Rose, M | 2 |
| Ivey, J | 2 |
| Boyd, C | 2 |
| Coupland, NJ | 1 |
| Ogilvie, CJ | 1 |
| Hegadoren, KM | 1 |
| Allen, PS | 1 |
| O'Neill, J | 1 |
| Smith, EA | 1 |
| Yildiz-Yesiloglu, A | 1 |
| Ankerst, DP | 1 |
| Amital, D | 1 |
| Vishne, T | 1 |
| Roitman, S | 1 |
| Kotler, M | 1 |
| Demirakca, T | 1 |
| Walter, S | 1 |
| Wokrina, T | 1 |
| Sartorius, A | 1 |
| Wildgruber, D | 1 |
| Ajilore, O | 1 |
| Haroon, E | 1 |
| Kumaran, S | 1 |
| Darwin, C | 1 |
| Binesh, N | 1 |
| Mintz, J | 2 |
| Miller, J | 1 |
| Thomas, MA | 1 |
| Kumar, A | 2 |
| Bhagwagar, Z | 1 |
| Wylezinska, M | 1 |
| Jezzard, P | 1 |
| Evans, J | 1 |
| Boorman, E | 1 |
| M Matthews, P | 1 |
| J Cowen, P | 1 |
| Hess, DA | 1 |
| Babb, JS | 1 |
| Klein, RG | 1 |
| Gonen, O | 1 |
| Schuff, N | 1 |
| Neylan, TC | 1 |
| Fox-Bosetti, S | 1 |
| Lenoci, M | 1 |
| Samuelson, KW | 1 |
| Studholme, C | 1 |
| Kornak, J | 1 |
| Marmar, CR | 1 |
| Weiner, MW | 1 |
| Pütz, B | 1 |
| Kraft, E | 1 |
| Lipinski, B | 1 |
| Schill, J | 1 |
| Holsboer, F | 1 |
| Murata, T | 1 |
| Kimura, H | 1 |
| Omori, M | 1 |
| Kado, H | 1 |
| Kosaka, H | 1 |
| Iidaka, T | 1 |
| Itoh, H | 1 |
| Wada, Y | 1 |
| Kusumakar, V | 1 |
| Gates, L | 1 |
| Sparkes, SJ | 1 |
| Khan, SC | 1 |
| Thomas, A | 1 |
| Lavretsky, H | 1 |
| Yue, K | 1 |
| Huda, A | 1 |
| Curran, J | 1 |
| Venkatraman, T | 1 |
| Estanol, L | 1 |
| Mega, M | 1 |
| Toga, A | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Efficacy and Safety of Augmentation of Creatine for the Patients With Major Depressive Disorder[NCT00729755] | 59 participants (Actual) | Interventional | 2008-08-31 | Completed | |||
| Creatine Augmentation in Female & Male Veterans With Selective Serotonin Reuptake Inhibitor-Resistant Major Depressive Disorder[NCT01175616] | Phase 4 | 0 participants (Actual) | Interventional | 2012-09-30 | Withdrawn (stopped due to Study withdrawn from ClinicalTrials.gov.) | ||
| Adjunctive Creatine Treatment for Adolescent Females With Major Depressive Disorder Who Are Non-Responders to Fluoxetine or Escitalopram: A Magnetic Resonance Spectroscopy Study[NCT00851006] | Phase 2 | 13 participants (Actual) | Interventional | 2009-04-30 | Completed | ||
| Placebo-Controlled Trial of Creatine Augmentation for Adolescent Females With Treatment-Resistant Major Depressive Disorder: a Magnetic Resonance Spectroscopy Study[NCT02134808] | Phase 4 | 71 participants (Actual) | Interventional | 2014-11-21 | Completed | ||
| Creatine Monohydrate Use for Preventing Altitude Induced Depression[NCT03433651] | Phase 4 | 0 participants (Actual) | Interventional | 2019-01-01 | Withdrawn (stopped due to Unable to locate grant funding.) | ||
| An Investigation of the Antidepressant Efficacy of Memantine, an NMDA Antagonist With Neurotrophic Properties in Major Depression[NCT00040261] | Phase 3 | 112 participants | Interventional | 2002-06-30 | Completed | ||
| An Investigation of the Antidepressant Efficacy of an Antiglutamatergic Agent in Bipolar Depression[NCT00054704] | Phase 2 | 19 participants (Actual) | Interventional | 2003-02-28 | Terminated (stopped due to Placebo was better than active drug.) | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Phosphocreatine Metabolite is a phosphorylated creatine molecule that plays a role in the production of the energy in the body. Phosphocreatine (PCr) metabolite was quantified by calculating the ratio of PCr over total phosphorus resonance from 31-Phosphorus Magnetic Resonance Spectroscopy. (NCT00851006)
Timeframe: 8 weeks
| Intervention | ratio of PCr and total phosphorus (Mean) | |
|---|---|---|
| Baseline | After 8 weeks | |
| Healthy Control Group | 0.1556 | 0.1558 |
| Open Label Creatine Treatment | 0.1513 | 0.1610 |
The CDRS-R is a 17-item scale, with items ranging from 1 to 5 or 1 to 7 (possible total score from 17 to 113), rated by a clinician via interviews with the child or parent. Scores ≥40 are indicative of depression, whereas scores ≤28 is often used to define remission (NCT00851006)
Timeframe: 8 weeks
| Intervention | Units on a scale (Mean) | |
|---|---|---|
| Baseline | After 8 week Creatine treatment | |
| Open Label Creatine Treatment | 69 | 30.6 |
The Montgomery-Asberg Depression Rating Scale (MADRS) is a clinician-rated assessment of depression symptoms. Patients were rated weekly on 10 symptoms on a scale of 0 to 6 for each item, where 0 indicated no symptoms and 6 indicated the highest severity of that symptom. Total scores range from 0 to 60, where a moderate severity of depression would be present with a score of at least 20. (NCT00054704)
Timeframe: 8 weeks
| Intervention | Units on a scale (Least Squares Mean) |
|---|---|
| Riluzole | 29.551 |
| Placebo | 23.723 |
3 reviews available for creatine and Depression, Involutional
| Article | Year |
|---|---|
Creatine for the Treatment of Depression.
Topics: Animals; Bipolar Disorder; Brain; Clinical Studies as Topic; Creatine; Depressive Disorder, Major; E | 2019 |
Neurobiology of generalized anxiety disorder.
Topics: Anxiety Disorders; Aspartic Acid; Brain; Cognition; Comorbidity; Creatine; Depressive Disorder, Majo | 2009 |
Review of 1H magnetic resonance spectroscopy findings in major depressive disorder: a meta-analysis.
Topics: Aspartic Acid; Brain; Choline; Creatine; Depressive Disorder, Major; gamma-Aminobutyric Acid; Glutam | 2006 |
8 trials available for creatine and Depression, Involutional
| Article | Year |
|---|---|
A pilot dose-finding clinical trial of creatine monohydrate augmentation to SSRIs/SNRIs/NASA antidepressant treatment in major depression.
Topics: Adult; Aged; Antidepressive Agents; Creatine; Depressive Disorder, Major; Dose-Response Relationship | 2013 |
The effect of 12-wk ω-3 fatty acid supplementation on in vivo thalamus glutathione concentration in patients "at risk" for major depression.
Topics: Aged; Aged, 80 and over; Cognition Disorders; Creatine; Depressive Disorder, Major; Dietary Suppleme | 2015 |
Effects of Creatine Monohydrate Augmentation on Brain Metabolic and Network Outcome Measures in Women With Major Depressive Disorder.
Topics: Adult; Aged; Aspartic Acid; Brain; Case-Control Studies; Citalopram; Creatine; Depressive Disorder, | 2016 |
The glutamatergic system and its relation to the clinical effect of therapeutic-sleep deprivation in depression - an MR spectroscopy study.
Topics: Adult; Aged; Analysis of Variance; Antidepressive Agents; Choline; Creatine; Depressive Disorder, Ma | 2009 |
Open-label adjunctive creatine for female adolescents with SSRI-resistant major depressive disorder: a 31-phosphorus magnetic resonance spectroscopy study.
Topics: Adolescent; Antidepressive Agents; Creatine; Depressive Disorder; Depressive Disorder, Major; Female | 2011 |
Open-label adjunctive creatine for female adolescents with SSRI-resistant major depressive disorder: a 31-phosphorus magnetic resonance spectroscopy study.
Topics: Adolescent; Antidepressive Agents; Creatine; Depressive Disorder; Depressive Disorder, Major; Female | 2011 |
Open-label adjunctive creatine for female adolescents with SSRI-resistant major depressive disorder: a 31-phosphorus magnetic resonance spectroscopy study.
Topics: Adolescent; Antidepressive Agents; Creatine; Depressive Disorder; Depressive Disorder, Major; Female | 2011 |
Open-label adjunctive creatine for female adolescents with SSRI-resistant major depressive disorder: a 31-phosphorus magnetic resonance spectroscopy study.
Topics: Adolescent; Antidepressive Agents; Creatine; Depressive Disorder; Depressive Disorder, Major; Female | 2011 |
Open-label adjunctive creatine for female adolescents with SSRI-resistant major depressive disorder: a 31-phosphorus magnetic resonance spectroscopy study.
Topics: Adolescent; Antidepressive Agents; Creatine; Depressive Disorder; Depressive Disorder, Major; Female | 2011 |
Open-label adjunctive creatine for female adolescents with SSRI-resistant major depressive disorder: a 31-phosphorus magnetic resonance spectroscopy study.
Topics: Adolescent; Antidepressive Agents; Creatine; Depressive Disorder; Depressive Disorder, Major; Female | 2011 |
Open-label adjunctive creatine for female adolescents with SSRI-resistant major depressive disorder: a 31-phosphorus magnetic resonance spectroscopy study.
Topics: Adolescent; Antidepressive Agents; Creatine; Depressive Disorder; Depressive Disorder, Major; Female | 2011 |
Open-label adjunctive creatine for female adolescents with SSRI-resistant major depressive disorder: a 31-phosphorus magnetic resonance spectroscopy study.
Topics: Adolescent; Antidepressive Agents; Creatine; Depressive Disorder; Depressive Disorder, Major; Female | 2011 |
Open-label adjunctive creatine for female adolescents with SSRI-resistant major depressive disorder: a 31-phosphorus magnetic resonance spectroscopy study.
Topics: Adolescent; Antidepressive Agents; Creatine; Depressive Disorder; Depressive Disorder, Major; Female | 2011 |
Hippocampal N-acetylaspartate and morning cortisol levels in drug-naive, first-episode patients with major depressive disorder: effects of treatment.
Topics: Adolescent; Adult; Antidepressive Agents; Aspartic Acid; Case-Control Studies; Choline; Creatine; De | 2012 |
A randomized, double-blind placebo-controlled trial of oral creatine monohydrate augmentation for enhanced response to a selective serotonin reuptake inhibitor in women with major depressive disorder.
Topics: Administration, Oral; Adult; Aged; Antidepressive Agents; Citalopram; Creatine; Depressive Disorder, | 2012 |
A randomized, double-blind placebo-controlled trial of oral creatine monohydrate augmentation for enhanced response to a selective serotonin reuptake inhibitor in women with major depressive disorder.
Topics: Administration, Oral; Adult; Aged; Antidepressive Agents; Citalopram; Creatine; Depressive Disorder, | 2012 |
A randomized, double-blind placebo-controlled trial of oral creatine monohydrate augmentation for enhanced response to a selective serotonin reuptake inhibitor in women with major depressive disorder.
Topics: Administration, Oral; Adult; Aged; Antidepressive Agents; Citalopram; Creatine; Depressive Disorder, | 2012 |
A randomized, double-blind placebo-controlled trial of oral creatine monohydrate augmentation for enhanced response to a selective serotonin reuptake inhibitor in women with major depressive disorder.
Topics: Administration, Oral; Adult; Aged; Antidepressive Agents; Citalopram; Creatine; Depressive Disorder, | 2012 |
A randomized, double-blind placebo-controlled trial of oral creatine monohydrate augmentation for enhanced response to a selective serotonin reuptake inhibitor in women with major depressive disorder.
Topics: Administration, Oral; Adult; Aged; Antidepressive Agents; Citalopram; Creatine; Depressive Disorder, | 2012 |
A randomized, double-blind placebo-controlled trial of oral creatine monohydrate augmentation for enhanced response to a selective serotonin reuptake inhibitor in women with major depressive disorder.
Topics: Administration, Oral; Adult; Aged; Antidepressive Agents; Citalopram; Creatine; Depressive Disorder, | 2012 |
A randomized, double-blind placebo-controlled trial of oral creatine monohydrate augmentation for enhanced response to a selective serotonin reuptake inhibitor in women with major depressive disorder.
Topics: Administration, Oral; Adult; Aged; Antidepressive Agents; Citalopram; Creatine; Depressive Disorder, | 2012 |
A randomized, double-blind placebo-controlled trial of oral creatine monohydrate augmentation for enhanced response to a selective serotonin reuptake inhibitor in women with major depressive disorder.
Topics: Administration, Oral; Adult; Aged; Antidepressive Agents; Citalopram; Creatine; Depressive Disorder, | 2012 |
A randomized, double-blind placebo-controlled trial of oral creatine monohydrate augmentation for enhanced response to a selective serotonin reuptake inhibitor in women with major depressive disorder.
Topics: Administration, Oral; Adult; Aged; Antidepressive Agents; Citalopram; Creatine; Depressive Disorder, | 2012 |
Open study of creatine monohydrate in treatment-resistant posttraumatic stress disorder.
Topics: Adult; Comorbidity; Creatine; Depressive Disorder, Major; Diagnostic and Statistical Manual of Menta | 2006 |
51 other studies available for creatine and Depression, Involutional
| Article | Year |
|---|---|
Correlations between facial emotion processing and biochemical abnormalities in untreated adolescent patients with major depressive disorder: A proton magnetic resonance spectroscopy study.
Topics: Adolescent; Aspartic Acid; Choline; Creatine; Depressive Disorder, Major; Emotions; Humans; Prefront | 2022 |
Associations between executive function impairment and biochemical abnormalities in depressed adolescents with non-suicidal self-injury.
Topics: Adolescent; Aspartic Acid; Choline; Creatine; Depressive Disorder, Major; Executive Function; Humans | 2022 |
Childhood trauma history is linked to abnormal brain metabolism of non-medicated adult patients with major depressive disorder.
Topics: Adult; Adverse Childhood Experiences; Aspartic Acid; Brain; Child, Preschool; Choline; Creatine; Cro | 2022 |
Similarities and differences in working memory and neurometabolism of obsessive-compulsive disorder and major depressive disorder.
Topics: Creatine; Depressive Disorder, Major; Humans; Magnetic Resonance Imaging; Memory Disorders; Memory, | 2022 |
Variation in Thyroid-Stimulating Hormone and Cognitive Disorders in Unmedicated Middle-Aged Patients with Major Depressive Disorder: A Proton Magnetic Resonance Spectroscopy Study.
Topics: Cognition; Creatine; Depressive Disorder, Major; Humans; Middle Aged; Proton Magnetic Resonance Spec | 2022 |
Decreased GABA+ Levels in the Medial Prefrontal Cortex of Perimenopausal Women: A 3T 1H-MRS Study.
Topics: Adult; Creatine; Depressive Disorder, Major; Female; gamma-Aminobutyric Acid; Humans; Magnetic Reson | 2023 |
Cognitive dysfunction and neurometabolic alternations in major depressive disorder with gastrointestinal symptoms.
Topics: Aspartic Acid; Choline; Cognitive Dysfunction; Creatine; Depressive Disorder, Major; Humans; Proton | 2023 |
Plasma Neuronal and Glial Markers and Anterior Cingulate Metabolite Levels in Major Depressive Disorder: A Pilot Study.
Topics: Adult; Aspartic Acid; Choline; Creatine; Depressive Disorder, Major; Female; Gyrus Cinguli; Humans; | 2020 |
Altered neurometabolism in major depressive disorder: A whole brain
Topics: Adult; Aspartic Acid; Brain; Choline; Creatine; Depressive Disorder, Major; Energy Metabolism; Femal | 2020 |
Neurotransmitters and Neurometabolites in Late-Life Depression: A Preliminary Magnetic Resonance Spectroscopy Study at 7T.
Topics: Aspartic Acid; Creatine; Depression; Depressive Disorder, Major; Glutamic Acid; Gyrus Cinguli; Human | 2021 |
Sex-Based Impact of Creatine Supplementation on Depressive Symptoms, Brain Serotonin and SSRI Efficacy in an Animal Model of Treatment-Resistant Depression.
Topics: Animals; Brain; Creatine; Depressive Disorder, Major; Dietary Supplements; Drug Synergism; Energy Me | 2021 |
A pilot study of cortical glutathione in youth with depression.
Topics: Adolescent; Anhedonia; Aspartic Acid; Case-Control Studies; Child; Choline; Creatine; Depression; De | 2017 |
Correlations between working memory impairment and neurometabolites of prefrontal cortex and lenticular nucleus in patients with major depressive disorder.
Topics: Adult; Aspartic Acid; Case-Control Studies; Choline; Corpus Striatum; Creatine; Depressive Disorder, | 2018 |
Left fimbria atrophy is associated with hippocampal metabolism in female major depressive disorder patients.
Topics: Atrophy; Creatine; Depressive Disorder, Major; Female; Hippocampus; Humans; Magnetic Resonance Imagi | 2018 |
Progressive decrease of N-acetylaspartate to total creatine ratio in the pregenual anterior cingulate cortex in patients with major depressive disorder: longitudinal 1H-MR spectroscopy study.
Topics: Adult; Antidepressive Agents; Aspartic Acid; Case-Control Studies; Choline; Creatine; Cross-Sectiona | 2014 |
Anterior cingulate cortex choline levels in female adolescents with unipolar versus bipolar depression: a potential new tool for diagnosis.
Topics: Adolescent; Analysis of Variance; Bipolar Disorder; Choline; Creatine; Cross-Sectional Studies; Depr | 2014 |
Similarities of biochemical abnormalities between major depressive disorder and bipolar depression: a proton magnetic resonance spectroscopy study.
Topics: Adolescent; Adult; Aspartic Acid; Bipolar Disorder; Brain; Choline; Creatine; Depressive Disorder, M | 2014 |
Oxidative stress and depressive symptoms in older adults: A magnetic resonance spectroscopy study.
Topics: Aged; Aged, 80 and over; Brain; Creatine; Depression; Depressive Disorder, Major; Female; Glutathion | 2015 |
The correlation between biochemical abnormalities in frontal white matter, hippocampus and serum thyroid hormone levels in first-episode patients with major depressive disorder.
Topics: Adult; Aspartic Acid; Brain Chemistry; Choline; Creatine; Depressive Disorder, Major; Female; Hippoc | 2015 |
Increased ventricular cerebrospinal fluid lactate in depressed adolescents.
Topics: Adolescent; Aspartic Acid; Cerebral Ventricles; Cerebrospinal Fluid; Choline; Creatine; Depressive D | 2016 |
A spectroscopic approach toward depression diagnosis: local metabolism meets functional connectivity.
Topics: Adult; Cerebral Cortex; Connectome; Creatine; Depressive Disorder, Major; Female; Glutamic Acid; Glu | 2017 |
Main Effects of Diagnoses, Brain Regions, and their Interaction Effects for Cerebral Metabolites in Bipolar and Unipolar Depressive Disorders.
Topics: Adult; Aspartic Acid; Biomarkers; Bipolar Disorder; Case-Control Studies; Choline; Creatine; Depress | 2016 |
Medial temporal N-acetyl-aspartate in pediatric major depression.
Topics: Adolescent; Aspartic Acid; Child; Choline; Creatine; Depressive Disorder, Major; Female; Humans; Mal | 2008 |
Biochemical abnormalities of the medial temporal lobe and medial prefrontal cortex in late-life depression.
Topics: Aspartic Acid; Choline; Creatine; Depressive Disorder, Major; Energy Metabolism; Functional Laterali | 2009 |
Proton magnetic resonance spectroscopy of late-life major depressive disorder.
Topics: Aged; Aging; Aspartic Acid; Basal Ganglia; Biomarkers; Brain; Choline; Cognition; Creatine; Depressi | 2009 |
Antidepressant effect detected on proton magnetic resonance spectroscopy in drug-naïve female patients with first-episode major depression.
Topics: Adult; Antidepressive Agents; Aspartic Acid; Case-Control Studies; Choline; Creatine; Depressive Dis | 2009 |
Normal metabolite levels in the left dorsolateral prefrontal cortex of unmedicated major depressive disorder patients: a single voxel (1)H spectroscopy study.
Topics: Adolescent; Adult; Aspartic Acid; Brain Mapping; Case-Control Studies; Chi-Square Distribution; Crea | 2009 |
Neuroanatomical correlates of depression in post traumatic brain injury: preliminary results of a pilot study.
Topics: Adult; Aspartic Acid; Basal Ganglia; Brain; Brain Injuries; Case-Control Studies; Choline; Cognition | 2010 |
Brain proton magnetic resonance spectroscopic study of insight among elders with late-life depression in remission.
Topics: Aged; Aspartic Acid; Awareness; Choline; Creatine; Depressive Disorder, Major; Dominance, Cerebral; | 2010 |
Reduced medial prefrontal N-acetyl-aspartate levels in pediatric major depressive disorder: a multi-voxel in vivo(1)H spectroscopy study.
Topics: Adolescent; Affect; Aspartic Acid; Brain Mapping; Child; Creatine; Depressive Disorder, Major; Femal | 2010 |
Abnormal cingulate and prefrontal cortical neurochemistry in major depression after electroconvulsive therapy.
Topics: Adult; Analysis of Variance; Aspartic Acid; Creatine; Depressive Disorder, Major; Electroconvulsive | 2011 |
Frontal white matter biochemical abnormalities in first-episode, treatment-naive patients with major depressive disorder: a proton magnetic resonance spectroscopy study.
Topics: Adolescent; Adult; Aspartic Acid; Brain Chemistry; Brain Diseases; Choline; Creatine; Depressive Dis | 2012 |
Plasma metabonomics as a novel diagnostic approach for major depressive disorder.
Topics: Acetates; Adult; Amino Acids; Biomarkers; Case-Control Studies; Creatine; Creatinine; Depressive Dis | 2012 |
Reduced γ-aminobutyric acid in occipital and anterior cingulate cortices in primary insomnia: a link to major depressive disorder?
Topics: Actigraphy; Adult; Brain Mapping; Case-Control Studies; Creatine; Depressive Disorder, Major; Female | 2012 |
Bioenergetics for depression: something different for depression.
Topics: Citalopram; Creatine; Depressive Disorder, Major; Drug Therapy, Combination; Female; Humans; Selecti | 2012 |
Long-term follow-up of magnetic resonance-detectable choline signal changes in the hippocampus of patients treated with electroconvulsive therapy.
Topics: Aspartic Acid; Choline; Cognition Disorders; Creatine; Depressive Disorder, Major; Electroconvulsive | 2003 |
Focal and lateralized subcortical abnormalities in unipolar major depressive disorder: an automated multivoxel proton magnetic resonance spectroscopy study.
Topics: Adult; Aspartic Acid; Brain; Brain Chemistry; Brain Mapping; Choline; Creatine; Depressive Disorder, | 2003 |
Proton magnetic resonance spectroscopy in first episode psychosis and ultra high-risk individuals.
Topics: Adolescent; Adult; Aspartic Acid; Bipolar Disorder; Brain Mapping; Choline; Creatine; Depressive Dis | 2003 |
Hippocampal neurochemical pathology in patients at first episode of affective psychosis: a proton magnetic resonance spectroscopic imaging study.
Topics: Adolescent; Adult; Aspartic Acid; Bipolar Disorder; Cerebral Cortex; Choline; Creatine; Depressive D | 2004 |
Reduced anterior cingulate glutamatergic concentrations in childhood OCD and major depression versus healthy controls.
Topics: Adolescent; Aspartic Acid; Child; Choline; Creatine; Depressive Disorder, Major; Female; Glutamic Ac | 2004 |
Decreased prefrontal Myo-inositol in major depressive disorder.
Topics: Adult; Aspartic Acid; Brain Chemistry; Brain Mapping; Case-Control Studies; Choline; Creatine; Depre | 2005 |
Increased medial thalamic creatine-phosphocreatine found by proton magnetic resonance spectroscopy in children with obsessive-compulsive disorder versus major depression and healthy controls.
Topics: Adolescent; Brain Mapping; Child; Creatine; Depressive Disorder, Major; Dominance, Cerebral; Energy | 2006 |
Subcortical and medial temporal MR-detectable metabolite abnormalities in unipolar major depression.
Topics: Adult; Aspartic Acid; Brain Chemistry; Cell Membrane; Cerebral Cortex; Creatine; Depressive Disorder | 2007 |
Measurement of brain metabolites in patients with type 2 diabetes and major depression using proton magnetic resonance spectroscopy.
Topics: Adult; Aged; Aged, 80 and over; Aspartic Acid; Brain Chemistry; Choline; Creatine; Depressive Disord | 2007 |
Low GABA concentrations in occipital cortex and anterior cingulate cortex in medication-free, recovered depressed patients.
Topics: Adult; Case-Control Studies; Creatine; Depressive Disorder, Major; Down-Regulation; Feasibility Stud | 2008 |
Lateralized caudate metabolic abnormalities in adolescent major depressive disorder: a proton MR spectroscopy study.
Topics: Adolescent; Aspartic Acid; Caudate Nucleus; Choline; Cohort Studies; Creatine; Depressive Disorder, | 2007 |
Abnormal N-acetylaspartate in hippocampus and anterior cingulate in posttraumatic stress disorder.
Topics: Adult; Alcoholism; Algorithms; Aspartic Acid; Atrophy; Combat Disorders; Comorbidity; Conditioning, | 2008 |
Reduced glutamate in the anterior cingulate cortex in depression: an in vivo proton magnetic resonance spectroscopy study.
Topics: Adult; Aged; Aspartic Acid; Choline; Creatine; Depressive Disorder, Major; Female; Frontal Lobe; Glu | 2000 |
Reduced glutamate in the anterior cingulate cortex in depression: an in vivo proton magnetic resonance spectroscopy study.
Topics: Adult; Aged; Aspartic Acid; Choline; Creatine; Depressive Disorder, Major; Female; Frontal Lobe; Glu | 2000 |
Reduced glutamate in the anterior cingulate cortex in depression: an in vivo proton magnetic resonance spectroscopy study.
Topics: Adult; Aged; Aspartic Acid; Choline; Creatine; Depressive Disorder, Major; Female; Frontal Lobe; Glu | 2000 |
Reduced glutamate in the anterior cingulate cortex in depression: an in vivo proton magnetic resonance spectroscopy study.
Topics: Adult; Aged; Aspartic Acid; Choline; Creatine; Depressive Disorder, Major; Female; Frontal Lobe; Glu | 2000 |
MRI white matter hyperintensities, (1)H-MR spectroscopy and cognitive function in geriatric depression: a comparison of early- and late-onset cases.
Topics: Aged; Alzheimer Disease; Aspartic Acid; Brain; Choline; Creatine; Depressive Disorder, Major; Energy | 2001 |
Left medial temporal cytosolic choline in early onset depression.
Topics: Adolescent; Amygdala; Aspartic Acid; Choline; Creatine; Cytosol; Depressive Disorder, Major; Dominan | 2001 |
Frontal white matter biochemical abnormalities in late-life major depression detected with proton magnetic resonance spectroscopy.
Topics: Aged; Aspartic Acid; Choline; Creatine; Depressive Disorder, Major; Dominance, Cerebral; Energy Meta | 2002 |