creatine has been researched along with Dementia in 28 studies
Dementia: An acquired organic mental disorder with loss of intellectual abilities of sufficient severity to interfere with social or occupational functioning. The dysfunction is multifaceted and involves memory, behavior, personality, judgment, attention, spatial relations, language, abstract thought, and other executive functions. The intellectual decline is usually progressive, and initially spares the level of consciousness.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The purpose of this study was to determine cerebral myo-inositol (mI) in adults with Down syndrome (DS), and to trace the chronobiology of DS to Alzheimer disease (AD)." | 7.69 | Role of increased cerebral myo-inositol in the dementia of Down syndrome. ( Ross, BD; Shonk, T, 1995) |
| " Although changes in myo-inositol and creatine occur in the early stages of AD, abnormalities of N-acetyl aspartate do not occur in mild AD but progressively change with dementia severity." | 3.71 | Brain metabolite concentration and dementia severity in Alzheimer's disease: a (1)H MRS study. ( Alexander, GE; Chang, L; Huang, W; Krasuski, JS; Rapoport, SI; Schapiro, MB; Shetty, HU, 2001) |
| "The purpose of this study was to determine cerebral myo-inositol (mI) in adults with Down syndrome (DS), and to trace the chronobiology of DS to Alzheimer disease (AD)." | 3.69 | Role of increased cerebral myo-inositol in the dementia of Down syndrome. ( Ross, BD; Shonk, T, 1995) |
| "Dementia was an independent predictor of metabolite values." | 2.73 | Magnetic resonance spectroscopy performance for detection of dementia, Alzheimer's disease and mild cognitive impairment in a community-based survey. ( Antúnez, C; Carles, R; Fortuna, L; García Santos, JM; Gavrila, D; Jiménez Veiga, J; Navarro, C; Parrilla, G; Salmerón, D; Tormo, MJ; Torres del Río, S, 2008) |
| "Markers of nocturnal hypoxemia and SDB are associated with cerebral oxidative stress in older people at-risk for dementia, suggesting a potential mechanism by which SDB may contribute to brain degeneration, cognitive decline, and dementia." | 1.43 | Association of Anterior Cingulate Glutathione with Sleep Apnea in Older Adults At-Risk for Dementia. ( Cross, N; Duffy, SL; Grunstein, R; Hermens, DF; Hickie, IB; Lagopoulos, J; Lewis, SJ; Mowszowski, L; Naismith, SL; Terpening, Z, 2016) |
| "Disease-specific metabolic changes in Alzheimer's disease and frontotemporal dementia/Pick complex were examined by proton magnetic resonance spectroscopy at 3." | 1.33 | Magnetic resonance spectroscopic study of Alzheimer's disease and frontotemporal dementia/Pick complex. ( Abe, K; Hattori, N; Mihara, M; Sakoda, S; Sawada, T, 2006) |
| "Choline (Cho)/Cr was higher than normal in patients with AD, FTLD, and DLB." | 1.32 | 1H MR spectroscopy in common dementias. ( Boeve, BF; Edland, SD; Ferman, TJ; Ivnik, RJ; Jack, CR; Kantarci, K; Knopman, DS; O'Brien, PC; Petersen, RC; Smith, GE; Tang-Wai, DF; Tangalos, EG; Weigand, SD, 2004) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (3.57) | 18.7374 |
| 1990's | 5 (17.86) | 18.2507 |
| 2000's | 15 (53.57) | 29.6817 |
| 2010's | 6 (21.43) | 24.3611 |
| 2020's | 1 (3.57) | 2.80 |
| Authors | Studies |
|---|---|
| Lyros, E | 1 |
| Ragoschke-Schumm, A | 1 |
| Kostopoulos, P | 1 |
| Sehr, A | 1 |
| Backens, M | 1 |
| Kalampokini, S | 1 |
| Decker, Y | 1 |
| Lesmeister, M | 1 |
| Liu, Y | 1 |
| Reith, W | 1 |
| Fassbender, K | 1 |
| Kantarci, K | 3 |
| Targosz-Gajniak, MG | 1 |
| Siuda, JS | 1 |
| Wicher, MM | 1 |
| Banasik, TJ | 1 |
| Bujak, MA | 1 |
| Augusciak-Duma, AM | 1 |
| Opala, G | 1 |
| Almuqbel, M | 1 |
| Melzer, TR | 1 |
| Myall, DJ | 1 |
| MacAskill, MR | 1 |
| Pitcher, TL | 1 |
| Livingston, L | 1 |
| Wood, KL | 1 |
| Keenan, RJ | 1 |
| Dalrymple-Alford, JC | 1 |
| Anderson, TJ | 1 |
| Duffy, SL | 1 |
| Lagopoulos, J | 1 |
| Terpening, Z | 1 |
| Lewis, SJ | 1 |
| Grunstein, R | 1 |
| Mowszowski, L | 1 |
| Cross, N | 1 |
| Hermens, DF | 1 |
| Hickie, IB | 1 |
| Naismith, SL | 1 |
| Ryu, B | 1 |
| Kawamata, T | 1 |
| Wakai, T | 1 |
| Shimizu, M | 1 |
| Yagi, S | 1 |
| Shimizu, T | 1 |
| García Santos, JM | 1 |
| Gavrila, D | 1 |
| Antúnez, C | 1 |
| Tormo, MJ | 1 |
| Salmerón, D | 1 |
| Carles, R | 1 |
| Jiménez Veiga, J | 1 |
| Parrilla, G | 1 |
| Torres del Río, S | 1 |
| Fortuna, L | 1 |
| Navarro, C | 1 |
| Caserta, MT | 1 |
| Ragin, A | 1 |
| Hermida, AP | 1 |
| Ahrens, RJ | 1 |
| Wise, L | 1 |
| Weigand, SD | 2 |
| Przybelski, SA | 1 |
| Shiung, MM | 1 |
| Whitwell, JL | 1 |
| Negash, S | 1 |
| Knopman, DS | 2 |
| Boeve, BF | 2 |
| O'Brien, PC | 2 |
| Petersen, RC | 2 |
| Jack, CR | 2 |
| Pilatus, U | 1 |
| Lais, C | 1 |
| Rochmont, Adu M | 1 |
| Kratzsch, T | 1 |
| Frölich, L | 1 |
| Maurer, K | 1 |
| Zanella, FE | 1 |
| Lanfermann, H | 1 |
| Pantel, J | 1 |
| Jickling, G | 1 |
| Salam, A | 1 |
| Mohammad, A | 1 |
| Hussain, MS | 1 |
| Scozzafava, J | 1 |
| Nasser, AM | 1 |
| Jeerakathil, T | 1 |
| Shuaib, A | 1 |
| Camicioli, R | 1 |
| Buschkuehl, M | 1 |
| Jaeggi, SM | 1 |
| Weiss, U | 1 |
| Bacher, R | 1 |
| Vonbank, H | 1 |
| Kemmler, G | 1 |
| Lingg, A | 1 |
| Marksteiner, J | 1 |
| Kizu, O | 1 |
| Yamada, K | 1 |
| Ito, H | 1 |
| Nishimura, T | 1 |
| Tang-Wai, DF | 1 |
| Edland, SD | 1 |
| Smith, GE | 1 |
| Ivnik, RJ | 1 |
| Ferman, TJ | 1 |
| Tangalos, EG | 1 |
| Frederick, BD | 1 |
| Lyoo, IK | 1 |
| Satlin, A | 1 |
| Ahn, KH | 1 |
| Kim, MJ | 1 |
| Yurgelun-Todd, DA | 1 |
| Cohen, BM | 1 |
| Renshaw, PF | 1 |
| Pfefferbaum, A | 1 |
| Adalsteinsson, E | 1 |
| Sullivan, EV | 1 |
| Metastasio, A | 1 |
| Rinaldi, P | 1 |
| Tarducci, R | 1 |
| Mariani, E | 1 |
| Feliziani, FT | 1 |
| Cherubini, A | 1 |
| Pelliccioli, GP | 1 |
| Gobbi, G | 1 |
| Senin, U | 1 |
| Mecocci, P | 1 |
| Mihara, M | 1 |
| Hattori, N | 1 |
| Abe, K | 1 |
| Sakoda, S | 1 |
| Sawada, T | 1 |
| Rami, L | 1 |
| Caprile, C | 1 |
| Gómez-Ansón, B | 1 |
| Sánchez-Valle, R | 1 |
| Monte, GC | 1 |
| Bosch, B | 1 |
| Molinuevo, JL | 1 |
| Xuan, X | 1 |
| Ding, M | 1 |
| Gong, X | 1 |
| Constans, JM | 1 |
| Meyerhoff, DJ | 1 |
| Gerson, J | 1 |
| MacKay, S | 1 |
| Norman, D | 1 |
| Fein, G | 1 |
| Weiner, MW | 1 |
| Shonk, T | 1 |
| Ross, BD | 2 |
| Shonk, TK | 1 |
| Moats, RA | 1 |
| Gifford, P | 1 |
| Michaelis, T | 1 |
| Mandigo, JC | 1 |
| Izumi, J | 1 |
| Bowen, BC | 1 |
| Block, RE | 1 |
| Sanchez-Ramos, J | 1 |
| Pattany, PM | 1 |
| Lampman, DA | 1 |
| Murdoch, JB | 1 |
| Quencer, RM | 1 |
| Shiino, A | 1 |
| Matsuda, M | 1 |
| Morikawa, S | 1 |
| Inubushi, T | 1 |
| Akiguchi, I | 1 |
| Handa, J | 1 |
| Huang, W | 1 |
| Alexander, GE | 1 |
| Chang, L | 1 |
| Shetty, HU | 1 |
| Krasuski, JS | 1 |
| Rapoport, SI | 1 |
| Schapiro, MB | 1 |
| Berlet, HH | 1 |
| Pilz, H | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Open Label Study for the Use of Tyrosine Kinase Inhibitors for Treatment of Cognitive Decline Due to Degenerative Dementias[NCT02921477] | Phase 1 | 150 participants (Anticipated) | Interventional | 2016-09-30 | Enrolling by invitation | ||
| Focused Ultrasound Delivery of Exosomes for Treatment of Refractory Depression, Anxiety, and Neurodegenerative Dementias[NCT04202770] | 300 participants (Anticipated) | Interventional | 2019-12-01 | Suspended (stopped due to Pending COVID-19 pandemic; pending status of product development) | |||
| MRI Biomarkers of Risk in Sedentary and Exercise Trained Humans[NCT02729428] | 71 participants (Actual) | Observational | 2016-04-30 | Completed | |||
| An Open-label Exploratory Study With Memantine: Correlation Between Proton Magnetic Resonance Spectroscopy, Cerebrospinal Fluid Biomarkers, and Cognition in Patients With Mild to Moderate Alzheimer's Disease[NCT00551161] | Phase 4 | 12 participants (Actual) | Interventional | 2007-08-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Ratios of myo-inositol (mI), N-acetylaspartate (NAA), total creatine (Cr), and choline (Cho) by single voxel 1H MRS (proton magnetic resonance spectroscopy). Mean (± SD) metabolite levels (normalized to T2-corrected water signal intensity) and metabolite ratios for Alzheimer's disease subjects at baseline (t0), after 24 weeks of ongoing monotherapy with stable-dose cholinesterase inhibitor (t1), and after another 24 weeks of combination therapy with memantine in addition to stable-dose cholinesterase inhibitor (t2). The Wilcoxon signed-rank test was used to examine whether the change between t0 and t1 differed from the change between t1 and t2 [(t2 - t1) - (t1 - t0)]. (NCT00551161)
Timeframe: Baseline, 24 weeks, and 48 weeks
| Intervention | ratio (normalized to T2-corrected water (Mean) | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| Change in NAA [(t2-t1) - (t1-t0)] | Change in Cr [(t2-t1) - (t1-t0)] | Change in Cho [(t2-t1) - (t1-t0)] | Change in mI [(t2-t1) - (t1-t0)] | Change in NAA/Cr [(t2-t1) - (t1-t0)] | Change in Cho/Cr [(t2-t1) - (t1-t0)] | Change in mI/Cr [(t2-t1) - (t1-t0)] | Change in NAA/Cho [(t2-t1) - (t1-t0)] | Change in NAA/mI [(t2-t1) - (t1-t0)] | |
| Memantine | -54 | -2 | 9 | 16 | -0.09 | 0.02 | 0.04 | -0.26 | -0.35 |
2 reviews available for creatine and Dementia
| Article | Year |
|---|---|
Proton MRS in mild cognitive impairment.
Topics: Alzheimer Disease; Animals; Aspartic Acid; Biomarkers; Brain; Choline; Cognitive Dysfunction; Creati | 2013 |
Improving intelligence: a literature review.
Topics: Achievement; Adolescent; Adult; Aged; Attention Deficit Disorder with Hyperactivity; Central Nervous | 2010 |
2 trials available for creatine and Dementia
| Article | Year |
|---|---|
Magnetic resonance spectroscopy performance for detection of dementia, Alzheimer's disease and mild cognitive impairment in a community-based survey.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Aspartic Acid; Brain; Choline; Cognition Disorders; Crea | 2008 |
Probable Alzheimer disease: diagnosis with proton MR spectroscopy.
Topics: Aged; Alzheimer Disease; Aspartic Acid; Brain; Brain Diseases, Metabolic; Creatine; Dementia; Diagno | 1995 |
24 other studies available for creatine and Dementia
| Article | Year |
|---|---|
Normal brain aging and Alzheimer's disease are associated with lower cerebral pH: an in vivo histidine
Topics: Adult; Aged; Aged, 80 and over; Aging; Alzheimer Disease; Brain; Cognitive Dysfunction; Creatine; De | 2020 |
Magnetic resonance spectroscopy as a predictor of conversion of mild cognitive impairment to dementia.
Topics: Aged; Aged, 80 and over; Aspartic Acid; Brain; Choline; Cognitive Dysfunction; Creatine; Dementia; D | 2013 |
Magnetic resonance spectroscopy as a predictor of conversion of mild cognitive impairment to dementia.
Topics: Aged; Aged, 80 and over; Aspartic Acid; Brain; Choline; Cognitive Dysfunction; Creatine; Dementia; D | 2013 |
Magnetic resonance spectroscopy as a predictor of conversion of mild cognitive impairment to dementia.
Topics: Aged; Aged, 80 and over; Aspartic Acid; Brain; Choline; Cognitive Dysfunction; Creatine; Dementia; D | 2013 |
Magnetic resonance spectroscopy as a predictor of conversion of mild cognitive impairment to dementia.
Topics: Aged; Aged, 80 and over; Aspartic Acid; Brain; Choline; Cognitive Dysfunction; Creatine; Dementia; D | 2013 |
Metabolite ratios in the posterior cingulate cortex do not track cognitive decline in Parkinson's disease in a clinical setting.
Topics: Aged; Aged, 80 and over; Aspartic Acid; Bayes Theorem; Case-Control Studies; Choline; Cognitive Dysf | 2016 |
Association of Anterior Cingulate Glutathione with Sleep Apnea in Older Adults At-Risk for Dementia.
Topics: Aged; Aging; Biomarkers; Cognition Disorders; Cognitive Dysfunction; Creatine; Dementia; Depression; | 2016 |
Reversible Cerebral Metabolism Changes Using Proton Magnetic Resonance Spectroscopy in a Patient with Intracranial Dural Arteriovenous Fistula: A Case Report.
Topics: Aged; Aspartic Acid; Central Nervous System Vascular Malformations; Coronary Angiography; Creatine; | 2016 |
Single voxel magnetic resonance spectroscopy at 3 Tesla in a memory disorders clinic: early right hippocampal NAA/Cr loss in mildly impaired subjects.
Topics: Aged; Aspartic Acid; Choline; Creatine; Dementia; Female; Functional Laterality; Hippocampus; Humans | 2008 |
Risk of dementia in MCI: combined effect of cerebrovascular disease, volumetric MRI, and 1H MRS.
Topics: Aged; Aged, 80 and over; Aspartic Acid; Atrophy; Biomarkers; Brain; Cerebrovascular Disorders; Cogni | 2009 |
Conversion to dementia in mild cognitive impairment is associated with decline of N-actylaspartate and creatine as revealed by magnetic resonance spectroscopy.
Topics: Aged; Alzheimer Disease; Aspartic Acid; Brain; Choline; Cognition; Cognition Disorders; Creatine; De | 2009 |
Circulating endothelial progenitor cells and age-related white matter changes.
Topics: Age Distribution; Aged; Aging; Angiotensin-Converting Enzyme Inhibitors; Brain; C-Reactive Protein; | 2009 |
Cognitive impairment: assessment with brain magnetic resonance imaging and proton magnetic resonance spectroscopy.
Topics: Aged; Alzheimer Disease; Aspartic Acid; Brain; Brain Chemistry; Choline; Cognition Disorders; Creati | 2003 |
Posterior cingulate metabolic changes in frontotemporal lobar degeneration detected by magnetic resonance spectroscopy.
Topics: Adult; Aged; Alzheimer Disease; Aspartic Acid; Case-Control Studies; Choline; Creatine; Dementia; Di | 2004 |
1H MR spectroscopy in common dementias.
Topics: Acetylcholine; Aged; Aged, 80 and over; Alzheimer Disease; Aspartic Acid; Brain; Brain Chemistry; Ch | 2004 |
In vivo proton magnetic resonance spectroscopy of the temporal lobe in Alzheimer's disease.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Analysis of Variance; Aspartic Acid; Brain Mapping; Case | 2004 |
Cortical NAA deficits in HIV infection without dementia: influence of alcoholism comorbidity.
Topics: Adult; Alcoholism; Aspartic Acid; Brain Mapping; Case-Control Studies; Cerebral Cortex; Choline; Com | 2005 |
Conversion of MCI to dementia: Role of proton magnetic resonance spectroscopy.
Topics: Aged; Amnesia; Aspartic Acid; Cerebral Cortex; Choline; Cognition Disorders; Creatine; Dementia; Dis | 2006 |
Magnetic resonance spectroscopic study of Alzheimer's disease and frontotemporal dementia/Pick complex.
Topics: Aged; Alzheimer Disease; Aspartic Acid; Brain Mapping; Cerebral Cortex; Creatine; Dementia; Down-Reg | 2006 |
Naming is associated with left temporal pole metabolite levels in neurodegenerative diseases.
Topics: Aged; Amnesia; Anomia; Aspartic Acid; Choline; Cognition Disorders; Creatine; Dementia; Female; Huma | 2008 |
Proton magnetic resonance spectroscopy detects a relative decrease of N-acetylaspartate in the hippocampus of patients with dementia with Lewy bodies.
Topics: Aged; Aspartic Acid; Chi-Square Distribution; Choline; Creatine; Dementia; Female; Hippocampus; Huma | 2008 |
H-1 MR spectroscopic imaging of white matter signal hyperintensities: Alzheimer disease and ischemic vascular dementia.
Topics: Aged; Alzheimer Disease; Aspartic Acid; Brain; Brain Diseases; Brain Ischemia; Case-Control Studies; | 1995 |
Role of increased cerebral myo-inositol in the dementia of Down syndrome.
Topics: Adolescent; Adult; Alzheimer Disease; Aspartic Acid; Brain; Child; Child, Preschool; Choline; Creati | 1995 |
Proton MR spectroscopy of the brain in 14 patients with Parkinson disease.
Topics: Adult; Aged; Aged, 80 and over; Aspartic Acid; Brain; Choline; Creatine; Dementia; Energy Metabolism | 1995 |
Proton magnetic resonance spectroscopy with dementia.
Topics: Adult; Aged; Aged, 80 and over; Alzheimer Disease; Aspartic Acid; Creatine; Dementia; Female; Humans | 1993 |
Brain metabolite concentration and dementia severity in Alzheimer's disease: a (1)H MRS study.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Analysis of Variance; Aspartic Acid; Brain; Choline; Cre | 2001 |
[Significance of plasma creatine and neurologic disorders for the creatine level of cerebrospinal fluid in man].
Topics: Amyotrophic Lateral Sclerosis; Creatine; Dementia; Encephalitis; Epilepsy; Humans; Meningitis; Multi | 1972 |