creatine has been researched along with Degenerative Diseases, Central Nervous System in 27 studies
| Excerpt | Relevance | Reference |
|---|---|---|
| "The supplementation of creatine has shown a marked neuroprotective effect in mouse models of neurodegenerative diseases (Parkinson's disease, Huntington's disease, amyotrophic lateral sclerosis)." | 8.87 | Creatine in mouse models of neurodegeneration and aging. ( Bender, A; Elstner, M; Klopstock, T, 2011) |
| "Creatine is a molecule that is produced both endogenously, and acquired exogenously through diet, and is an extremely important molecule that participates in buffering intracellular energy stores." | 6.44 | Creatine and its potential therapeutic value for targeting cellular energy impairment in neurodegenerative diseases. ( Adhihetty, PJ; Beal, MF, 2008) |
| "The supplementation of creatine has shown a marked neuroprotective effect in mouse models of neurodegenerative diseases (Parkinson's disease, Huntington's disease, amyotrophic lateral sclerosis)." | 4.87 | Creatine in mouse models of neurodegeneration and aging. ( Bender, A; Elstner, M; Klopstock, T, 2011) |
| "Creatine is a nitrogenous organic acid that plays a central role as an energy buffer in high energy demanding systems, including the muscular and the central nervous system." | 2.61 | Creatine as a Neuroprotector: an Actor that Can Play Many Parts. ( Marques, EP; Wyse, ATS, 2019) |
| "Creatine (Cr) is a natural compound that plays an important role in cellular energy homeostasis." | 2.53 | Creatine for neuroprotection in neurodegenerative disease: end of story? ( Bender, A; Klopstock, T, 2016) |
| "Creatine, however, was still neuroprotective in mice, which were deficient in mitochondrial creatine kinase." | 2.47 | Neuroprotective effects of creatine. ( Beal, MF, 2011) |
| "Creatine is a critical component in maintaining cellular energy homeostasis, and its administration has been reported to be neuroprotective in a wide number of both acute and chronic experimental models of neurological disease." | 2.44 | The neuroprotective role of creatine. ( Ferrante, RJ; Klein, AM, 2007) |
| "Creatine is a molecule that is produced both endogenously, and acquired exogenously through diet, and is an extremely important molecule that participates in buffering intracellular energy stores." | 2.44 | Creatine and its potential therapeutic value for targeting cellular energy impairment in neurodegenerative diseases. ( Adhihetty, PJ; Beal, MF, 2008) |
| "Creatine has been shown to be neuroprotective in aging, neurodegenerative conditions and brain injury." | 1.38 | Creatine protects against excitoxicity in an in vitro model of neurodegeneration. ( Bender, A; Geiger, J; Genius, J; Klopstock, T; Möller, HJ; Rujescu, D, 2012) |
| "PEHO syndrome is a rare symptom complex of severe progressive encephalopathy, edema, hypsarrhythmia, and optic atrophy." | 1.33 | Serial MR imaging, diffusion tensor imaging, and MR spectroscopic findings in a child with progressive encephalopathy, edema, hypsarrhythmia, and optic atrophy (PEHO) syndrome. ( Boltshauser, E; Huisman, TA; Klein, A; Straube, T; Werner, B, 2006) |
| "Choline (Cho)/Cr was higher than normal in patients with AD, FTLD, and DLB." | 1.32 | 1H MR spectroscopy in common dementias. ( Boeve, BF; Edland, SD; Ferman, TJ; Ivnik, RJ; Jack, CR; Kantarci, K; Knopman, DS; O'Brien, PC; Petersen, RC; Smith, GE; Tang-Wai, DF; Tangalos, EG; Weigand, SD, 2004) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (3.70) | 18.2507 |
| 2000's | 13 (48.15) | 29.6817 |
| 2010's | 10 (37.04) | 24.3611 |
| 2020's | 3 (11.11) | 2.80 |
| Authors | Studies |
|---|---|
| Schur, GM | 1 |
| Dunn, J | 1 |
| Nguyen, S | 1 |
| Dedio, A | 1 |
| Wade, K | 1 |
| Tamaroff, J | 1 |
| Mitta, N | 1 |
| Wilson, N | 1 |
| Reddy, R | 1 |
| Lynch, DR | 1 |
| McCormack, SE | 1 |
| Ostojic, SM | 1 |
| van Zijl, PCM | 1 |
| Brindle, K | 1 |
| Lu, H | 1 |
| Barker, PB | 1 |
| Edden, R | 1 |
| Yadav, N | 1 |
| Knutsson, L | 1 |
| Cervinkova, B | 1 |
| Krcmova, LK | 1 |
| Sestakova, V | 1 |
| Solichova, D | 1 |
| Solich, P | 1 |
| Marques, EP | 1 |
| Wyse, ATS | 1 |
| Liu, J | 1 |
| Wang, LN | 1 |
| Bender, A | 3 |
| Klopstock, T | 3 |
| Donadieu, M | 1 |
| Le Fur, Y | 1 |
| Confort-Gouny, S | 1 |
| Le Troter, A | 1 |
| Guye, M | 1 |
| Ranjeva, JP | 1 |
| Boban, J | 1 |
| Kozic, D | 1 |
| Turkulov, V | 1 |
| Ostojic, J | 1 |
| Semnic, R | 1 |
| Lendak, D | 1 |
| Brkic, S | 1 |
| Klein, AM | 1 |
| Ferrante, RJ | 1 |
| Adhihetty, PJ | 1 |
| Beal, MF | 2 |
| Rákóczi, K | 1 |
| Klivényi, P | 1 |
| Vécsei, L | 1 |
| Béard, E | 1 |
| Braissant, O | 1 |
| Elstner, M | 1 |
| Genius, J | 1 |
| Geiger, J | 1 |
| Möller, HJ | 1 |
| Rujescu, D | 1 |
| Gambini, A | 1 |
| Falini, A | 1 |
| Moiola, L | 1 |
| Comi, G | 1 |
| Scotti, G | 1 |
| Dolder, M | 1 |
| Walzel, B | 1 |
| Speer, O | 1 |
| Schlattner, U | 2 |
| Wallimann, T | 2 |
| Kantarci, K | 1 |
| Petersen, RC | 1 |
| Boeve, BF | 1 |
| Knopman, DS | 1 |
| Tang-Wai, DF | 1 |
| O'Brien, PC | 1 |
| Weigand, SD | 1 |
| Edland, SD | 1 |
| Smith, GE | 1 |
| Ivnik, RJ | 1 |
| Ferman, TJ | 1 |
| Tangalos, EG | 1 |
| Jack, CR | 1 |
| Peña-Altamira, E | 1 |
| Crochemore, C | 1 |
| Virgili, M | 1 |
| Contestabile, A | 1 |
| Yang, Y | 1 |
| Wu, Z | 1 |
| Kuo, YM | 1 |
| Zhou, B | 1 |
| Burguera, EF | 1 |
| Love, BJ | 1 |
| Schuff, N | 1 |
| Meyerhoff, DJ | 1 |
| Mueller, S | 1 |
| Chao, L | 1 |
| Sacrey, DT | 1 |
| Laxer, K | 1 |
| Weiner, MW | 1 |
| Huisman, TA | 1 |
| Klein, A | 1 |
| Werner, B | 1 |
| Straube, T | 1 |
| Boltshauser, E | 1 |
| Dreha-Kulaczewski, SF | 1 |
| Dechent, P | 1 |
| Finsterbusch, J | 1 |
| Brockmann, K | 1 |
| Gärtner, J | 1 |
| Frahm, J | 1 |
| Hanefeld, FA | 1 |
| Andres, RH | 1 |
| Ducray, AD | 1 |
| Widmer, HR | 1 |
| Terakawa, H | 1 |
| Abe, K | 1 |
| Watanabe, Y | 1 |
| Nakamura, M | 1 |
| Fujita, N | 1 |
| Hirabuki, N | 1 |
| Yanagihara, T | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| The Effect of Creatine Monohydrate on Persistent Post-concussive Symptoms - a Pilot Study Protocol[NCT05562232] | 45 participants (Anticipated) | Interventional | 2022-10-01 | Not yet recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
13 reviews available for creatine and Degenerative Diseases, Central Nervous System
| Article | Year |
|---|---|
Creatine and multiple sclerosis.
Topics: Brain; Creatine; Humans; Multiple Sclerosis; Neurodegenerative Diseases | 2022 |
Hyperpolarized MRI, functional MRI, MR spectroscopy and CEST to provide metabolic information in vivo.
Topics: Animals; Brain; Carbon Isotopes; Contrast Media; Creatine; Deep Learning; Glycogen; Humans; Liver; M | 2021 |
Creatine as a Neuroprotector: an Actor that Can Play Many Parts.
Topics: Animals; Brain; Creatine; Energy Metabolism; Humans; Mitochondria; Neurodegenerative Diseases; Neuro | 2019 |
Mitochondrial enhancement for neurodegenerative movement disorders: a systematic review of trials involving creatine, coenzyme Q10, idebenone and mitoquinone.
Topics: Animals; Creatine; Dose-Response Relationship, Drug; Humans; Mitochondria; Mitochondrial Diseases; N | 2014 |
Creatine for neuroprotection in neurodegenerative disease: end of story?
Topics: Animals; Creatine; Disease Models, Animal; Dose-Response Relationship, Drug; Humans; Neurodegenerati | 2016 |
The neuroprotective role of creatine.
Topics: Acute Disease; Adenosine Triphosphate; Animals; Cell Death; Chronic Disease; Creatine; Disease Model | 2007 |
Creatine and its potential therapeutic value for targeting cellular energy impairment in neurodegenerative diseases.
Topics: Adenosine Triphosphate; Animals; Creatine; Dietary Supplements; Energy Metabolism; Humans; Mitochond | 2008 |
[Neuroprotection in Parkinson's disease and other neurodegenerative disorders: preclinical and clinical findings].
Topics: Animals; Creatine; Dopamine Agonists; Glatiramer Acetate; Humans; Indans; Kynurenic Acid; Micronutri | 2009 |
Synthesis and transport of creatine in the CNS: importance for cerebral functions.
Topics: Amidinotransferases; Animals; Central Nervous System; Cerebral Cortex; Creatine; Guanidinoacetate N- | 2010 |
Creatine in mouse models of neurodegeneration and aging.
Topics: Aging; Animals; Creatine; Disease Models, Animal; Humans; Mice; Neurodegenerative Diseases; Rejuvena | 2011 |
Neuroprotective effects of creatine.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Creatine; Humans; Neurodegenerative Diseases; | 2011 |
N-acetylaspartate as a marker of neuronal injury in neurodegenerative disease.
Topics: Aging; Alcoholism; Amyotrophic Lateral Sclerosis; Aspartic Acid; Biomarkers; Brain; Brain Injuries; | 2006 |
Functions and effects of creatine in the central nervous system.
Topics: Animals; Brain Diseases, Metabolic; Brain Injuries; Central Nervous System; Creatine; Creatine Kinas | 2008 |
14 other studies available for creatine and Degenerative Diseases, Central Nervous System
| Article | Year |
|---|---|
In vivo assessment of OXPHOS capacity using 3 T CrCEST MRI in Friedreich's ataxia.
Topics: Adult; Creatine; Friedreich Ataxia; Humans; Iron-Binding Proteins; Magnetic Resonance Imaging; Neuro | 2022 |
A fully validated bioanalytical method using an UHPLC-MS/MS system for quantification of DNA and RNA oxidative stress biomarkers.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Adult; Biomarkers; Chromatography, High Pressure Liquid; Creatine; Deox | 2017 |
Evidencing different neurochemical profiles between thalamic nuclei using high resolution 2D-PRESS semi-LASER (1)H-MRSI at 7 T.
Topics: Adult; Analysis of Variance; Aspartic Acid; Brain; Choline; Creatine; Female; Healthy Volunteers; Hu | 2016 |
HIV-associated neurodegeneration and neuroimmunity: multivoxel MR spectroscopy study in drug-naïve and treated patients.
Topics: Adult; AIDS Dementia Complex; Aspartic Acid; Biomarkers; Brain; Case-Control Studies; Choline; Creat | 2017 |
Creatine protects against excitoxicity in an in vitro model of neurodegeneration.
Topics: Animals; Cells, Cultured; Cerebral Cortex; Creatine; Energy Metabolism; Glutamic Acid; Hippocampus; | 2012 |
Marchiafava-Bignami disease: longitudinal MR imaging and MR spectroscopy study.
Topics: Alcohol-Related Disorders; Atrophy; Choline; Corpus Callosum; Creatine; Demyelinating Diseases; Huma | 2003 |
Inhibition of the mitochondrial permeability transition by creatine kinase substrates. Requirement for microcompartmentation.
Topics: Adenine; Adenosine Diphosphate; Adenosine Triphosphate; Animals; Calcium; Cell Survival; Chromatogra | 2003 |
1H MR spectroscopy in common dementias.
Topics: Acetylcholine; Aged; Aged, 80 and over; Alzheimer Disease; Aspartic Acid; Brain; Brain Chemistry; Ch | 2004 |
Neurochemical correlates of differential neuroprotection by long-term dietary creatine supplementation.
Topics: Acetylcholine; Amyotrophic Lateral Sclerosis; Animals; Basal Nucleus of Meynert; Biomarkers; Brain; | 2005 |
Dietary rescue of fumble--a Drosophila model for pantothenate-kinase-associated neurodegeneration.
Topics: Acetylcysteine; Adenosine Triphosphate; Animal Feed; Animals; Ascorbic Acid; Carnitine; Cloning, Mol | 2005 |
Reduced transglutaminase-catalyzed protein aggregation is observed in the presence of creatine using sedimentation velocity.
Topics: Centrifugation, Density Gradient; Creatine; Humans; Lasers; Microspheres; Neurodegenerative Diseases | 2006 |
Serial MR imaging, diffusion tensor imaging, and MR spectroscopic findings in a child with progressive encephalopathy, edema, hypsarrhythmia, and optic atrophy (PEHO) syndrome.
Topics: Aspartic Acid; Atrophy; Brain Diseases; Brain Edema; Cerebellum; Child; Choline; Creatine; Diffusion | 2006 |
Early reduction of total N-acetyl-aspartate-compounds in patients with classical vanishing white matter disease. A long-term follow-up MRS study.
Topics: Adolescent; Adult; Aspartic Acid; Axons; Brain Diseases; Cerebrum; Child; Child, Preschool; Creatine | 2008 |
Proton magnetic resonance spectroscopy (1H MRS) in patients with sporadic cerebellar degeneration.
Topics: Adult; Aged; Aspartic Acid; Atrophy; Cerebellar Diseases; Cerebellum; Choline; Creatine; Disease Pro | 1999 |