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creatine and Degenerative Diseases, Central Nervous System

creatine has been researched along with Degenerative Diseases, Central Nervous System in 27 studies

Research Excerpts

ExcerptRelevanceReference
"The supplementation of creatine has shown a marked neuroprotective effect in mouse models of neurodegenerative diseases (Parkinson's disease, Huntington's disease, amyotrophic lateral sclerosis)."8.87Creatine in mouse models of neurodegeneration and aging. ( Bender, A; Elstner, M; Klopstock, T, 2011)
"Creatine is a molecule that is produced both endogenously, and acquired exogenously through diet, and is an extremely important molecule that participates in buffering intracellular energy stores."6.44Creatine and its potential therapeutic value for targeting cellular energy impairment in neurodegenerative diseases. ( Adhihetty, PJ; Beal, MF, 2008)
"The supplementation of creatine has shown a marked neuroprotective effect in mouse models of neurodegenerative diseases (Parkinson's disease, Huntington's disease, amyotrophic lateral sclerosis)."4.87Creatine in mouse models of neurodegeneration and aging. ( Bender, A; Elstner, M; Klopstock, T, 2011)
"Creatine is a nitrogenous organic acid that plays a central role as an energy buffer in high energy demanding systems, including the muscular and the central nervous system."2.61Creatine as a Neuroprotector: an Actor that Can Play Many Parts. ( Marques, EP; Wyse, ATS, 2019)
"Creatine (Cr) is a natural compound that plays an important role in cellular energy homeostasis."2.53Creatine for neuroprotection in neurodegenerative disease: end of story? ( Bender, A; Klopstock, T, 2016)
"Creatine, however, was still neuroprotective in mice, which were deficient in mitochondrial creatine kinase."2.47Neuroprotective effects of creatine. ( Beal, MF, 2011)
"Creatine is a critical component in maintaining cellular energy homeostasis, and its administration has been reported to be neuroprotective in a wide number of both acute and chronic experimental models of neurological disease."2.44The neuroprotective role of creatine. ( Ferrante, RJ; Klein, AM, 2007)
"Creatine is a molecule that is produced both endogenously, and acquired exogenously through diet, and is an extremely important molecule that participates in buffering intracellular energy stores."2.44Creatine and its potential therapeutic value for targeting cellular energy impairment in neurodegenerative diseases. ( Adhihetty, PJ; Beal, MF, 2008)
"Creatine has been shown to be neuroprotective in aging, neurodegenerative conditions and brain injury."1.38Creatine protects against excitoxicity in an in vitro model of neurodegeneration. ( Bender, A; Geiger, J; Genius, J; Klopstock, T; Möller, HJ; Rujescu, D, 2012)
"PEHO syndrome is a rare symptom complex of severe progressive encephalopathy, edema, hypsarrhythmia, and optic atrophy."1.33Serial MR imaging, diffusion tensor imaging, and MR spectroscopic findings in a child with progressive encephalopathy, edema, hypsarrhythmia, and optic atrophy (PEHO) syndrome. ( Boltshauser, E; Huisman, TA; Klein, A; Straube, T; Werner, B, 2006)
"Choline (Cho)/Cr was higher than normal in patients with AD, FTLD, and DLB."1.321H MR spectroscopy in common dementias. ( Boeve, BF; Edland, SD; Ferman, TJ; Ivnik, RJ; Jack, CR; Kantarci, K; Knopman, DS; O'Brien, PC; Petersen, RC; Smith, GE; Tang-Wai, DF; Tangalos, EG; Weigand, SD, 2004)

Research

Studies (27)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's1 (3.70)18.2507
2000's13 (48.15)29.6817
2010's10 (37.04)24.3611
2020's3 (11.11)2.80

Authors

AuthorsStudies
Schur, GM1
Dunn, J1
Nguyen, S1
Dedio, A1
Wade, K1
Tamaroff, J1
Mitta, N1
Wilson, N1
Reddy, R1
Lynch, DR1
McCormack, SE1
Ostojic, SM1
van Zijl, PCM1
Brindle, K1
Lu, H1
Barker, PB1
Edden, R1
Yadav, N1
Knutsson, L1
Cervinkova, B1
Krcmova, LK1
Sestakova, V1
Solichova, D1
Solich, P1
Marques, EP1
Wyse, ATS1
Liu, J1
Wang, LN1
Bender, A3
Klopstock, T3
Donadieu, M1
Le Fur, Y1
Confort-Gouny, S1
Le Troter, A1
Guye, M1
Ranjeva, JP1
Boban, J1
Kozic, D1
Turkulov, V1
Ostojic, J1
Semnic, R1
Lendak, D1
Brkic, S1
Klein, AM1
Ferrante, RJ1
Adhihetty, PJ1
Beal, MF2
Rákóczi, K1
Klivényi, P1
Vécsei, L1
Béard, E1
Braissant, O1
Elstner, M1
Genius, J1
Geiger, J1
Möller, HJ1
Rujescu, D1
Gambini, A1
Falini, A1
Moiola, L1
Comi, G1
Scotti, G1
Dolder, M1
Walzel, B1
Speer, O1
Schlattner, U2
Wallimann, T2
Kantarci, K1
Petersen, RC1
Boeve, BF1
Knopman, DS1
Tang-Wai, DF1
O'Brien, PC1
Weigand, SD1
Edland, SD1
Smith, GE1
Ivnik, RJ1
Ferman, TJ1
Tangalos, EG1
Jack, CR1
Peña-Altamira, E1
Crochemore, C1
Virgili, M1
Contestabile, A1
Yang, Y1
Wu, Z1
Kuo, YM1
Zhou, B1
Burguera, EF1
Love, BJ1
Schuff, N1
Meyerhoff, DJ1
Mueller, S1
Chao, L1
Sacrey, DT1
Laxer, K1
Weiner, MW1
Huisman, TA1
Klein, A1
Werner, B1
Straube, T1
Boltshauser, E1
Dreha-Kulaczewski, SF1
Dechent, P1
Finsterbusch, J1
Brockmann, K1
Gärtner, J1
Frahm, J1
Hanefeld, FA1
Andres, RH1
Ducray, AD1
Widmer, HR1
Terakawa, H1
Abe, K1
Watanabe, Y1
Nakamura, M1
Fujita, N1
Hirabuki, N1
Yanagihara, T1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
The Effect of Creatine Monohydrate on Persistent Post-concussive Symptoms - a Pilot Study Protocol[NCT05562232]45 participants (Anticipated)Interventional2022-10-01Not yet recruiting
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

13 reviews available for creatine and Degenerative Diseases, Central Nervous System

ArticleYear
Creatine and multiple sclerosis.
    Nutritional neuroscience, 2022, Volume: 25, Issue:5

    Topics: Brain; Creatine; Humans; Multiple Sclerosis; Neurodegenerative Diseases

2022
Hyperpolarized MRI, functional MRI, MR spectroscopy and CEST to provide metabolic information in vivo.
    Current opinion in chemical biology, 2021, Volume: 63

    Topics: Animals; Brain; Carbon Isotopes; Contrast Media; Creatine; Deep Learning; Glycogen; Humans; Liver; M

2021
Creatine as a Neuroprotector: an Actor that Can Play Many Parts.
    Neurotoxicity research, 2019, Volume: 36, Issue:2

    Topics: Animals; Brain; Creatine; Energy Metabolism; Humans; Mitochondria; Neurodegenerative Diseases; Neuro

2019
Mitochondrial enhancement for neurodegenerative movement disorders: a systematic review of trials involving creatine, coenzyme Q10, idebenone and mitoquinone.
    CNS drugs, 2014, Volume: 28, Issue:1

    Topics: Animals; Creatine; Dose-Response Relationship, Drug; Humans; Mitochondria; Mitochondrial Diseases; N

2014
Creatine for neuroprotection in neurodegenerative disease: end of story?
    Amino acids, 2016, Volume: 48, Issue:8

    Topics: Animals; Creatine; Disease Models, Animal; Dose-Response Relationship, Drug; Humans; Neurodegenerati

2016
The neuroprotective role of creatine.
    Sub-cellular biochemistry, 2007, Volume: 46

    Topics: Acute Disease; Adenosine Triphosphate; Animals; Cell Death; Chronic Disease; Creatine; Disease Model

2007
Creatine and its potential therapeutic value for targeting cellular energy impairment in neurodegenerative diseases.
    Neuromolecular medicine, 2008, Volume: 10, Issue:4

    Topics: Adenosine Triphosphate; Animals; Creatine; Dietary Supplements; Energy Metabolism; Humans; Mitochond

2008
[Neuroprotection in Parkinson's disease and other neurodegenerative disorders: preclinical and clinical findings].
    Ideggyogyaszati szemle, 2009, Jan-30, Volume: 62, Issue:1-2

    Topics: Animals; Creatine; Dopamine Agonists; Glatiramer Acetate; Humans; Indans; Kynurenic Acid; Micronutri

2009
Synthesis and transport of creatine in the CNS: importance for cerebral functions.
    Journal of neurochemistry, 2010, Volume: 115, Issue:2

    Topics: Amidinotransferases; Animals; Central Nervous System; Cerebral Cortex; Creatine; Guanidinoacetate N-

2010
Creatine in mouse models of neurodegeneration and aging.
    Amino acids, 2011, Volume: 40, Issue:5

    Topics: Aging; Animals; Creatine; Disease Models, Animal; Humans; Mice; Neurodegenerative Diseases; Rejuvena

2011
Neuroprotective effects of creatine.
    Amino acids, 2011, Volume: 40, Issue:5

    Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Creatine; Humans; Neurodegenerative Diseases;

2011
N-acetylaspartate as a marker of neuronal injury in neurodegenerative disease.
    Advances in experimental medicine and biology, 2006, Volume: 576

    Topics: Aging; Alcoholism; Amyotrophic Lateral Sclerosis; Aspartic Acid; Biomarkers; Brain; Brain Injuries;

2006
Functions and effects of creatine in the central nervous system.
    Brain research bulletin, 2008, Jul-01, Volume: 76, Issue:4

    Topics: Animals; Brain Diseases, Metabolic; Brain Injuries; Central Nervous System; Creatine; Creatine Kinas

2008

Other Studies

14 other studies available for creatine and Degenerative Diseases, Central Nervous System

ArticleYear
In vivo assessment of OXPHOS capacity using 3 T CrCEST MRI in Friedreich's ataxia.
    Journal of neurology, 2022, Volume: 269, Issue:5

    Topics: Adult; Creatine; Friedreich Ataxia; Humans; Iron-Binding Proteins; Magnetic Resonance Imaging; Neuro

2022
A fully validated bioanalytical method using an UHPLC-MS/MS system for quantification of DNA and RNA oxidative stress biomarkers.
    Analytical and bioanalytical chemistry, 2017, Volume: 409, Issue:14

    Topics: 8-Hydroxy-2'-Deoxyguanosine; Adult; Biomarkers; Chromatography, High Pressure Liquid; Creatine; Deox

2017
Evidencing different neurochemical profiles between thalamic nuclei using high resolution 2D-PRESS semi-LASER (1)H-MRSI at 7 T.
    Magma (New York, N.Y.), 2016, Volume: 29, Issue:3

    Topics: Adult; Analysis of Variance; Aspartic Acid; Brain; Choline; Creatine; Female; Healthy Volunteers; Hu

2016
HIV-associated neurodegeneration and neuroimmunity: multivoxel MR spectroscopy study in drug-naïve and treated patients.
    European radiology, 2017, Volume: 27, Issue:10

    Topics: Adult; AIDS Dementia Complex; Aspartic Acid; Biomarkers; Brain; Case-Control Studies; Choline; Creat

2017
Creatine protects against excitoxicity in an in vitro model of neurodegeneration.
    PloS one, 2012, Volume: 7, Issue:2

    Topics: Animals; Cells, Cultured; Cerebral Cortex; Creatine; Energy Metabolism; Glutamic Acid; Hippocampus;

2012
Marchiafava-Bignami disease: longitudinal MR imaging and MR spectroscopy study.
    AJNR. American journal of neuroradiology, 2003, Volume: 24, Issue:2

    Topics: Alcohol-Related Disorders; Atrophy; Choline; Corpus Callosum; Creatine; Demyelinating Diseases; Huma

2003
Inhibition of the mitochondrial permeability transition by creatine kinase substrates. Requirement for microcompartmentation.
    The Journal of biological chemistry, 2003, May-16, Volume: 278, Issue:20

    Topics: Adenine; Adenosine Diphosphate; Adenosine Triphosphate; Animals; Calcium; Cell Survival; Chromatogra

2003
1H MR spectroscopy in common dementias.
    Neurology, 2004, Oct-26, Volume: 63, Issue:8

    Topics: Acetylcholine; Aged; Aged, 80 and over; Alzheimer Disease; Aspartic Acid; Brain; Brain Chemistry; Ch

2004
Neurochemical correlates of differential neuroprotection by long-term dietary creatine supplementation.
    Brain research, 2005, Oct-05, Volume: 1058, Issue:1-2

    Topics: Acetylcholine; Amyotrophic Lateral Sclerosis; Animals; Basal Nucleus of Meynert; Biomarkers; Brain;

2005
Dietary rescue of fumble--a Drosophila model for pantothenate-kinase-associated neurodegeneration.
    Journal of inherited metabolic disease, 2005, Volume: 28, Issue:6

    Topics: Acetylcysteine; Adenosine Triphosphate; Animal Feed; Animals; Ascorbic Acid; Carnitine; Cloning, Mol

2005
Reduced transglutaminase-catalyzed protein aggregation is observed in the presence of creatine using sedimentation velocity.
    Analytical biochemistry, 2006, Mar-01, Volume: 350, Issue:1

    Topics: Centrifugation, Density Gradient; Creatine; Humans; Lasers; Microspheres; Neurodegenerative Diseases

2006
Serial MR imaging, diffusion tensor imaging, and MR spectroscopic findings in a child with progressive encephalopathy, edema, hypsarrhythmia, and optic atrophy (PEHO) syndrome.
    AJNR. American journal of neuroradiology, 2006, Volume: 27, Issue:7

    Topics: Aspartic Acid; Atrophy; Brain Diseases; Brain Edema; Cerebellum; Child; Choline; Creatine; Diffusion

2006
Early reduction of total N-acetyl-aspartate-compounds in patients with classical vanishing white matter disease. A long-term follow-up MRS study.
    Pediatric research, 2008, Volume: 63, Issue:4

    Topics: Adolescent; Adult; Aspartic Acid; Axons; Brain Diseases; Cerebrum; Child; Child, Preschool; Creatine

2008
Proton magnetic resonance spectroscopy (1H MRS) in patients with sporadic cerebellar degeneration.
    Journal of neuroimaging : official journal of the American Society of Neuroimaging, 1999, Volume: 9, Issue:2

    Topics: Adult; Aged; Aspartic Acid; Atrophy; Cerebellar Diseases; Cerebellum; Choline; Creatine; Disease Pro

1999