Page last updated: 2024-10-17

creatine and Coronary Disease

creatine has been researched along with Coronary Disease in 46 studies

Coronary Disease: An imbalance between myocardial functional requirements and the capacity of the CORONARY VESSELS to supply sufficient blood flow. It is a form of MYOCARDIAL ISCHEMIA (insufficient blood supply to the heart muscle) caused by a decreased capacity of the coronary vessels.

Research Excerpts

ExcerptRelevanceReference
"Hyperthyroid rat heart was studied with the purpose of identifying the mechanism for the significant decrease in total creatine (free creatine plus phosphocreatine) observed in this pathology and its consequences on heart function."7.67Hormone regulation of cardiac energy metabolism. I. Creatine transport across cell membranes of euthyroid and hyperthyroid rat heart. ( Adoyaan, AJ; Chernousova, GB; Kallikorm, AP; Lyulina, NV; Popovich, MI; Saks, VA; Seppet, EK; Severin, VV; Sharov, VG, 1985)
"We measured creatine kinase activity, isozyme composition, and total creatine content in biopsy samples of left ventricular myocardium from 34 adults in four groups: subjects with normal left ventricles, patients with left ventricular hypertrophy due to aortic stenosis, patients with coronary artery disease without left ventricular hypertrophy, and patients with coronary artery disease and left ventricular hypertrophy due to aortic stenosis."3.67The creatine kinase system in normal and diseased human myocardium. ( Allen, PD; Fifer, MA; Grossman, W; Ingwall, JS; Kramer, MF; Lorell, BH; Shemin, R, 1985)
"Hyperthyroid rat heart was studied with the purpose of identifying the mechanism for the significant decrease in total creatine (free creatine plus phosphocreatine) observed in this pathology and its consequences on heart function."3.67Hormone regulation of cardiac energy metabolism. I. Creatine transport across cell membranes of euthyroid and hyperthyroid rat heart. ( Adoyaan, AJ; Chernousova, GB; Kallikorm, AP; Lyulina, NV; Popovich, MI; Saks, VA; Seppet, EK; Severin, VV; Sharov, VG, 1985)
"The high prevalence of small LDL in diabetic nephropathy was also observed even when hypertriglyceridemic or hypertensive subjects were excluded from each group."1.29High prevalence of small LDL particles in non-insulin-dependent diabetic patients with nephropathy. ( Adachi, M; Ebara, T; Hirano, T; Kurokawa, M; Nagano, S; Naito, H; Yoshino, G, 1996)
"When verapamil was present before ischemia, pressure development during early ischemia was reduced to about 50% of control."1.27Verapamil protection of ischemic isolated rabbit heart: dependence on pretreatment. ( Bersohn, MM; Shine, KI, 1983)

Research

Studies (46)

TimeframeStudies, this research(%)All Research%
pre-199036 (78.26)18.7374
1990's5 (10.87)18.2507
2000's4 (8.70)29.6817
2010's1 (2.17)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Bonello, L1
De Labriolle, A1
Roy, P1
Steinberg, DH1
Okabe, T1
Pinto Slottow, TL1
Xue, Z1
Torguson, R1
Suddath, WO2
Satler, LF2
Kent, KM2
Pichard, AD2
Lindsay, J2
Waksman, R2
Mao, Y1
Yu, JM1
Zhang, F1
Zhan, YQ1
Hu, DY1
Jiang, QW1
Gruberg, L1
Weissman, NJ1
Pinnow, EE1
Gevorkian, N1
SCEBAT, L1
RENAIS, J1
LENEGRE, J1
LOCKWOOD, CH1
NICHOLLS, DM1
LEWIS, JA1
TROOP, VL1
JOHNSTON, LC1
GRIEBLE, HG1
SCHOENBERGER, JA1
FULLER, JB1
IMAI, S1
RILEY, AL1
BERNE, RM1
Weisbord, SD1
Chen, H1
Stone, RA1
Kip, KE1
Fine, MJ1
Saul, MI1
Palevsky, PM1
Schaeverbeke, T1
Héloire, F1
Deray, G1
Bersohn, MM1
Shine, KI3
Behrendt, W1
Minale, C1
Giani, G1
Douglas, AM2
Davydov, VV1
Tverdokhlib, VP1
Iakushev, VS1
Roberts, JJ1
Walker, JB1
Hirano, T1
Naito, H1
Kurokawa, M1
Ebara, T1
Nagano, S1
Adachi, M1
Yoshino, G1
Lip, GY1
Rathore, VS1
Katira, R1
Singh, SP1
Watson, RD1
Kohn, MC1
Achs, MJ1
Garfinkel, D1
Barlattani, M1
Guglielmi, G2
Mammarella, A2
Di Maio, F1
Neri, A1
Soccorsi, P1
Sciacca, A1
Rau, EE1
Gervais, A1
Amos, EC1
Cucchini, F1
Colla, B1
Di Donato, M1
Visioli, O1
Godfraind, T1
Reibel, DK1
Rovetto, MJ1
Sigurd, B1
Olesen, KH1
Wennevold, A1
Isselhard, W2
Lauterjung, KL2
Witte, J2
Ban, T1
Hübner, G1
Giersberg, O1
Heugel, E2
Hirt, HJ1
Geppert, E1
Menge, M1
Vogel, W1
Pisarenko, OI2
Studneva, IM2
Shul'zhenko, VS1
Khlopkov, VN1
Novikov, ID1
Kapel'ko, VI1
Zucchi, R2
Limbruno, U2
Di Vincenzo, A1
Mariani, M2
Ronca, G2
Otsu, N1
Yamaguchi, I1
Komatsu, E1
Miyazawa, K1
Oleynikov, OD1
Shulzhenko, VS1
Ryff, IM1
Kapelko, VI1
Poddighe, R1
Ronca-Testoni, S1
Zimmer, SD1
Uğurbil, K1
Michurski, SP1
Mohanakrishnan, P1
Ulstad, VK1
Foker, JE1
From, AH1
Ingwall, JS1
Kramer, MF1
Fifer, MA1
Lorell, BH1
Shemin, R1
Grossman, W1
Allen, PD1
Evanochko, WT1
Reeves, RC1
Sakai, TT1
Canby, RC1
Pohost, GM1
Fiolet, JW1
Baartscheer, A1
Schumacher, CA1
ter Welle, HF1
Krieger, WJ1
Sami, HM1
Koke, JR1
Bittar, N1
Seppet, EK1
Adoyaan, AJ1
Kallikorm, AP1
Chernousova, GB1
Lyulina, NV1
Sharov, VG1
Severin, VV1
Popovich, MI1
Saks, VA1
Fontana, A1
Lusena, S1
Mori, K1
Fox, AC1
Reed, GE1
Glassman, E1
Kaltman, AJ1
Silk, BB1
Telfer, N1
Persoff, M1
Chernukh, AM1
Vakar, MD1
Aleksandrov, PN1
Chernysheva, GV1
Stoĭda, LV1
Natale, L1
Moser, K2
Lujf, A2
Suko, J1

Clinical Trials (4)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Pragmatic Randomized Controlled Trial Comparing Treatment Effectiveness of Guideline Indicated Anti-platelet Therapy for Acute Coronary Syndrome in Patients With Chronic Kidney Disease[NCT03150667]Phase 4220 participants (Anticipated)Interventional2017-04-10Recruiting
Predictive Value of CHA2DS2-VASC Score and Contrast Volume to Creatinine Clearance Ratio in Relation to Mehran Score for Contrast-Induced Nephropathy In ST- Elevation Myocardial Infarction Patients Undergoing Primary Percutaneous Coronary Intervention[NCT03266458]210 participants (Anticipated)Observational [Patient Registry]2018-01-01Not yet recruiting
Phase III Study of Metabolic Intervention With Glutamate in Coronary Surgery II[NCT02592824]Phase 3321 participants (Actual)Interventional2015-11-15Completed
Phase III Study of Intravenous Glutamate Infusion for Metabolic Protection of the Heart in Surgery for Unstable Coronary Artery Disease[NCT00489827]Phase 3865 participants (Actual)Interventional2005-10-31Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

Incidence of Mortality

Postoperative mortality was defined as mortality within 30 days of surgery. (NCT02592824)
Timeframe: up to 30 days

InterventionParticipants (Count of Participants)
Intravenous Glutamate Infusion1
Intravenous Saline Infusion6

Incidence of Unexpected Adverse Events

suspected unexpected serious adverse reaction (NCT02592824)
Timeframe: within 24 hours from infusion

InterventionParticipants (Count of Participants)
Intravenous Glutamate Infusion0
Intravenous Saline Infusion0

Number of Participants With Incidence of Stroke

"Postoperative stroke was defined as neurological or cognitive deficit with a cerebral injury verified on (Computed Tomography) CT-scan. All suspected cases of stroke underwent CT-scan.~Stroke within 24 h of surgery was defined as a stroke that occurred within 24 h of surgery or signs of a stroke, when first assessable in deeply sedated patients on a ventilator." (NCT02592824)
Timeframe: within 24 hours from surgery

InterventionParticipants (Count of Participants)
Intravenous Glutamate Infusion0
Intravenous Saline Infusion4

Postoperative Increase of Plasma NT-proBNP

"Postoperative increase of NT-proBNP reflects postoperative myocardial dysfunction sustained in association with surgery. NT-proBNP usually peaks on the third to fourth postoperative day after coronary artery bypass surgery.~In the first GLUTAMICS trial a good agreement between hemodynamic criteria for postoperative heart failure and postoperative NT-proBNP was found." (NCT02592824)
Timeframe: from the day before surgery to the third postoperative day

Interventionng/L (Mean)
Intravenous Glutamate Infusion5390
Intravenous Saline Infusion6452

Postoperative Increase of Plasma NT-proBNP in Patients Without Diabetes

"Postoperative increase of NT-proBNP reflects postoperative myocardial dysfunction sustained in association with surgery. NT-proBNP usually peaks on the third to fourth postoperative day after coronary artery bypass surgery.~Previous observations suggest a blunted effect of glutamate in diabetic hearts." (NCT02592824)
Timeframe: from preoperative level to the third postoperative day

Interventionng/L (Mean)
Intravenous Glutamate Infusion4503
Intravenous Saline Infusion6825

Postoperative Plasma Level of NT-proBNP

Postoperative NT-proBNP reflects postoperative myocardial dysfunction. (NCT02592824)
Timeframe: first postoperative day

Interventionng/L (Mean)
Intravenous Glutamate Infusion4438
Intravenous Saline Infusion4420

Postoperative Plasma Level of NT-proBNP

Postoperative NT-proBNP reflects postoperative myocardial dysfunction. (NCT02592824)
Timeframe: third postoperative day

Interventionng/L (Mean)
Intravenous Glutamate Infusion8055
Intravenous Saline Infusion8804

Atrial Fibrillation

Number of patients with atrial fibrillation recorded postoperatively (NCT00489827)
Timeframe: Hospital stay

InterventionParticipants (Count of Participants)
Intravenous Glutamate147
Saline Infusion152

ICU Stay

ICU duration of stay (hours) (NCT00489827)
Timeframe: ICU stay

Interventionhours (Median)
Intravenous Glutamate21
Saline Infusion21

Number of Participants With Perioperative Myocardial Infarction, Postoperative Heart Failure or Postoperative Mortality

(NCT00489827)
Timeframe: 30 days

InterventionParticipants (Count of Participants)
Intravenous Glutamate31
Saline Infusion25

Number of Participants With Postoperative Stroke < 24 Hours

Incidence of Postoperative stroke < 24 hours of surgery verifed by CT-scan (NCT00489827)
Timeframe: 24 hours

InterventionParticipants (Count of Participants)
Intravenous Glutamate4
Saline Infusion6

Postoperative Hemodynamic State in Patients With Severely Reduced Left Ventricular Ejection Fraction (LVEF<0.40)

Hemodynamic instability despite inotropes or need for IABP at the end of surgery in patients with severely reduced left ventricular ejection fraction (LVEF<0.40) (NCT00489827)
Timeframe: End of surgery

InterventionParticipants (Count of Participants)
Intravenous Glutamate1
Saline Infusion5

Postoperative Renal Function

maximum p-creatinine value recorded postoperatively < 30 days (NCT00489827)
Timeframe: 30 days

Interventionµmol/L (Mean)
Intravenous Glutamate106
Saline Infusion106

Severe Circulatory Failure in CCS Class IV Patients

Severe circulatory failure according to prespecified criteria as judged by a blinded endpoints committee in CCS class IV patients (NCT00489827)
Timeframe: 30 days

InterventionParticipants (Count of Participants)
Intravenous Glutamate3
Saline Infusion16

Degree of Perioperative Myocardial Injury

p-CK-MB postoperative day 1, p-troponin-T postoperative day 3 (NCT00489827)
Timeframe: perioperative

,
Interventionµg/L (Median)
CK-MB day 1Troponin-T day 3
Intravenous Glutamate140.27
Saline Infusion140.24

Postoperative Hemodynamic State

Mixed venous oxygen saturation (SvO2) measured at weaning from cardiopulmonary bypass and on arrival to ICU (NCT00489827)
Timeframe: Until arrival to ICU

,
Interventionpercentage of saturated hemoglobin (Mean)
SvO2 at weaning from CPBSvO2 on arrival to ICU
Intravenous Glutamate72.065.0
Saline Infusion72.264.9

Trials

5 trials available for creatine and Coronary Disease

ArticleYear
[Parenteral feeding following heart surgery operations].
    Infusionstherapie und klinische Ernahrung, 1984, Volume: 11, Issue:6

    Topics: Blood Glucose; Blood Proteins; Blood Urea Nitrogen; Coronary Artery Bypass; Coronary Disease; Creati

1984
Creatinol O-phosphate therapy in patients with inadequate coronary circulation. Double-blind clinical trial.
    Arzneimittel-Forschung, 1979, Volume: 29, Issue:9a

    Topics: Adult; Aged; Blood Pressure; Clinical Trials as Topic; Coronary Disease; Creatine; Double-Blind Meth

1979
Activity of creatinol O-phosphate on persistent ventricular premature beats in ischemic heart disease. Double blind clinical trial.
    Arzneimittel-Forschung, 1979, Volume: 29, Issue:9a

    Topics: Aged; Arrhythmias, Cardiac; Clinical Trials as Topic; Coronary Disease; Creatine; Double-Blind Metho

1979
[Controlled clinical study of the use of creatinol-O-phosphate in subjects with deficient myocardial circulation].
    La Clinica terapeutica, 1979, Nov-30, Volume: 91, Issue:4

    Topics: Adult; Aged; Angina Pectoris; Arrhythmias, Cardiac; Clinical Trials as Topic; Coronary Disease; Crea

1979
The supra-additive natriuretic effect addition of bendroflumethiazide and bumetanide in congestive heart failure. Permutation trial tests in patients in long-term treatment with bumetanide.
    American heart journal, 1975, Volume: 89, Issue:2

    Topics: Adult; Bendroflumethiazide; Benzoates; Butylamines; Chlorides; Clinical Trials as Topic; Coronary Di

1975

Other Studies

41 other studies available for creatine and Coronary Disease

ArticleYear
Impact of optimal medical therapy and revascularization on outcome of patients with chronic kidney disease and on dialysis who presented with acute coronary syndrome.
    The American journal of cardiology, 2008, Sep-01, Volume: 102, Issue:5

    Topics: Acute Disease; Aged; Confidence Intervals; Coronary Angiography; Coronary Disease; Creatine; Disease

2008
[The association of target organ damage with abnormal ankle brachial index in hypertensive patients].
    Zhonghua nei ke za zhi, 2012, Volume: 51, Issue:2

    Topics: Adult; Aged; Aged, 80 and over; Ankle Brachial Index; Arteriosclerosis; China; Coronary Disease; Cre

2012
Impact of renal function on morbidity and mortality after percutaneous aortocoronary saphenous vein graft intervention.
    American heart journal, 2003, Volume: 145, Issue:3

    Topics: Age Factors; Aged; Comorbidity; Coronary Artery Bypass; Coronary Disease; Creatine; Diabetes Mellitu

2003
[Serum creatine-kinase in the diagnosis of myocardial lesions. (Clinical and experimental study)].
    Archives des maladies du coeur et des vaisseaux, 1961, Volume: 54

    Topics: Clinical Enzyme Tests; Coronary Disease; Creatine; Creatinine; Humans; Phosphotransferases

1961
THE DIURETIC EFFECT OF TRIAMTERENE.
    Medical services journal, Canada, 1964, Volume: 20

    Topics: Blood Chemical Analysis; Coronary Disease; Creatine; Creatinine; Diuretics; Heart Failure; Hypertens

1964
TREATMENT OF ARTERIAL HYPERTENSIVE DISEASE WITH DIURETICS. III. CHLORTHALIDONE ALONE AND IN COMBINATION WITH SPIRONOLACTONE.
    The American journal of the medical sciences, 1964, Volume: 247

    Topics: Bendroflumethiazide; Cardiomegaly; Chlorides; Chlorthalidone; Coronary Disease; Creatine; Creatinine

1964
EFFECT OF ISCHEMIA ON ADENINE NUCLEOTIDES IN CARDIAC AND SKELETAL MUSCLE.
    Circulation research, 1964, Volume: 15

    Topics: Adenine Nucleotides; Coenzymes; Coronary Disease; Creatine; Creatinine; Heart; Metabolism; Muscle, S

1964
Associations of increases in serum creatinine with mortality and length of hospital stay after coronary angiography.
    Journal of the American Society of Nephrology : JASN, 2006, Volume: 17, Issue:10

    Topics: Aged; Coronary Disease; Creatine; Female; Hospital Mortality; Humans; Kidney; Length of Stay; Male;

2006
[How to watch over a patient treated with a NSAID in relation to the cardiovascular and renal risk?].
    Presse medicale (Paris, France : 1983), 2006, Volume: 35, Issue:9 Spec No

    Topics: Adult; Age Factors; Aged; Algorithms; Anti-Inflammatory Agents, Non-Steroidal; Cardiovascular Diseas

2006
Verapamil protection of ischemic isolated rabbit heart: dependence on pretreatment.
    Journal of molecular and cellular cardiology, 1983, Volume: 15, Issue:10

    Topics: Adenosine Triphosphate; Animals; Blood Pressure; Calcium; Coronary Disease; Creatine; In Vitro Techn

1983
Low calcium reperfusion of ischemic myocardium.
    Journal of molecular and cellular cardiology, 1983, Volume: 15, Issue:4

    Topics: Adenosine Triphosphate; Animals; Calcium; Coronary Disease; Creatine; Electric Stimulation; Myocardi

1983
[Concentration of adenylic nucleotides and creatine phosphate in the cerebral hemispheres in various manifestations of stress].
    Zhurnal nevropatologii i psikhiatrii imeni S.S. Korsakova (Moscow, Russia : 1952), 1982, Volume: 82, Issue:5

    Topics: Adenine Nucleotides; Adenosine Triphosphate; Animals; Brain Chemistry; Coronary Disease; Creatine; N

1982
Feeding a creatine analogue delays ATP depletion and onset of rigor in ischemic heart.
    The American journal of physiology, 1982, Volume: 243, Issue:6

    Topics: Adenosine Triphosphate; Animals; Coronary Disease; Creatine; Creatinine; Heart; Kinetics; Male; Myoc

1982
High prevalence of small LDL particles in non-insulin-dependent diabetic patients with nephropathy.
    Atherosclerosis, 1996, Volume: 123, Issue:1-2

    Topics: Aged; Albuminuria; Apoproteins; Blood Glucose; Body Mass Index; Carrier Proteins; Cholesterol Ester

1996
Changes in renal function with percutaneous transluminal coronary angioplasty.
    International journal of cardiology, 1999, Jul-31, Volume: 70, Issue:2

    Topics: Angioplasty, Balloon, Coronary; Biomarkers; Coronary Disease; Creatine; Female; Follow-Up Studies; H

1999
Distribution of adenine nucleotides in the perfused rat heart.
    The American journal of physiology, 1977, Volume: 232, Issue:5

    Topics: Actins; Adenine Nucleotides; Animals; Computers; Coronary Disease; Creatine; Cytosol; Glucose; Hydro

1977
Enhanced mechanical recovery of anoxic and ischemic myocardium by amino acid perfusion.
    The American journal of physiology, 1979, Volume: 236, Issue:6

    Topics: Amino Acids; Animals; Arginine; Aspartic Acid; Coronary Disease; Creatine; Glutamates; Hypoxia; Male

1979
Enhanced mechanical recovery of anoxic and ischemic myocardium by amino acid perfusion.
    The American journal of physiology, 1979, Volume: 236, Issue:6

    Topics: Amino Acids; Animals; Arginine; Aspartic Acid; Coronary Disease; Creatine; Glutamates; Hypoxia; Male

1979
Enhanced mechanical recovery of anoxic and ischemic myocardium by amino acid perfusion.
    The American journal of physiology, 1979, Volume: 236, Issue:6

    Topics: Amino Acids; Animals; Arginine; Aspartic Acid; Coronary Disease; Creatine; Glutamates; Hypoxia; Male

1979
Enhanced mechanical recovery of anoxic and ischemic myocardium by amino acid perfusion.
    The American journal of physiology, 1979, Volume: 236, Issue:6

    Topics: Amino Acids; Animals; Arginine; Aspartic Acid; Coronary Disease; Creatine; Glutamates; Hypoxia; Male

1979
[Effects of creatinol-O-phosphate on left ventricular function in coronary disease patients].
    Bollettino della Societa italiana di cardiologia, 1978, Volume: 23, Issue:3

    Topics: Coronary Disease; Creatine; Heart Ventricles; Hemodynamics; Humans; Myocardial Contraction

1978
Concepts leading to the development of an anti-ischemic drug. Introductory remarks.
    Arzneimittel-Forschung, 1979, Volume: 29, Issue:9a

    Topics: Coronary Disease; Creatine; Hemodynamics; Humans; Myocardial Contraction; Necrosis

1979
Myocardial ATP synthesis and mechanical function following oxygen deficiency.
    The American journal of physiology, 1978, Volume: 234, Issue:5

    Topics: Adenosine; Adenosine Triphosphate; Animals; Coronary Disease; Creatine; In Vitro Techniques; Male; M

1978
Metabolic and structural recovery of left ventricular canine myocardium from regional complete ischemia.
    European surgical research. Europaische chirurgische Forschung. Recherches chirurgicales europeennes, 1975, Volume: 7, Issue:3

    Topics: Adenosine Diphosphate; Adenosine Monophosphate; Adenosine Triphosphate; Animals; Cell Nucleus; Colla

1975
Effect on myocardial metabolic pattern of local complete and incomplete ischemia.
    Recent advances in studies on cardiac structure and metabolism, 1975, Volume: 7

    Topics: Adenosine Monophosphate; Animals; Coronary Disease; Creatine; Disease Models, Animal; Dogs; Glycogen

1975
[Relation between the energy state of the myocardium and the release of products of anaerobic metabolism].
    Biokhimiia (Moscow, Russia), 1990, Volume: 55, Issue:1

    Topics: Adenosine Triphosphate; Alanine; Anaerobiosis; Animals; Bicarbonates; Buffers; Coronary Disease; Cre

1990
Adenine nucleotide depletion and contractile dysfunction in the "stunned" myocardium.
    Cardiovascular research, 1990, Volume: 24, Issue:6

    Topics: Adenine Nucleotides; Animals; Coronary Disease; Creatine; In Vitro Techniques; Myocardial Contractio

1990
[Immunoelectron microscopic studies on the localization of creatine kinase M in normal and ischemic myocardial cells].
    Rinsho byori. The Japanese journal of clinical pathology, 1990, Volume: 38, Issue:7

    Topics: Adenosine Triphosphate; Animals; Coronary Disease; Creatine; Creatine Kinase; Dogs; Energy Metabolis

1990
Association of myocardial glutamate and aspartate pool and functional recovery of postischemic heart.
    Biochemical medicine and metabolic biology, 1989, Volume: 42, Issue:2

    Topics: Adenosine Triphosphate; Animals; Aspartic Acid; Coronary Disease; Creatine; Energy Metabolism; Gluta

1989
Protection of isolated rat heart from oxidative stress by exogenous creatine phosphate.
    Journal of molecular and cellular cardiology, 1989, Volume: 21, Issue:1

    Topics: Animals; Coronary Disease; Creatine; Heart; Hemodynamics; Hydrogen Peroxide; Hypoxia; In Vitro Techn

1989
Alterations in oxidative function and respiratory regulation in the post-ischemic myocardium.
    The Journal of biological chemistry, 1989, Jul-25, Volume: 264, Issue:21

    Topics: Adenine Nucleotides; Adenosine Triphosphate; Animals; Coronary Disease; Creatine; Energy Metabolism;

1989
The creatine kinase system in normal and diseased human myocardium.
    The New England journal of medicine, 1985, Oct-24, Volume: 313, Issue:17

    Topics: Adult; Aged; Aortic Valve Stenosis; Cardiomegaly; Citrate (si)-Synthase; Coronary Disease; Creatine;

1985
Proton NMR spectroscopy in myocardial ischemic insult.
    Magnetic resonance in medicine, 1987, Volume: 5, Issue:1

    Topics: Animals; Coronary Circulation; Coronary Disease; Creatine; Dogs; Fatty Acids, Nonesterified; Lipid M

1987
Transmural inhomogeneity of energy metabolism during acute global ischemia in the isolated rat heart: dependence on environmental conditions.
    Journal of molecular and cellular cardiology, 1985, Volume: 17, Issue:1

    Topics: Adenosine Triphosphate; Animals; Collateral Circulation; Coronary Circulation; Coronary Disease; Cre

1985
Accelerated recovery of ischemic canine myocardium induced by AMP. Preliminary report.
    Advances in myocardiology, 1985, Volume: 6

    Topics: Adenosine Diphosphate; Adenosine Monophosphate; Adenosine Triphosphate; Animals; Coronary Disease; C

1985
Hormone regulation of cardiac energy metabolism. I. Creatine transport across cell membranes of euthyroid and hyperthyroid rat heart.
    Biochemical medicine, 1985, Volume: 34, Issue:3

    Topics: Animals; Cell Membrane; Coronary Disease; Creatine; Energy Metabolism; Hyperthyroidism; Kinetics; My

1985
[Clinical study on the effects of creatinol-O-phosphate in patients with heart diseases under digitalis treatment].
    Minerva medica, 1972, Nov-17, Volume: 63, Issue:82

    Topics: Aged; Alcohols; Arrhythmias, Cardiac; Coronary Disease; Creatine; Drug Synergism; Drug Tolerance; Fe

1972
[Effect of exercise on myocardial metabolism of inorganic phosphorus and creatine in patients with heart diseases].
    Japanese circulation journal, 1972, Volume: 36, Issue:10

    Topics: Adult; Asthenia; Coronary Disease; Coronary Vessels; Creatine; Female; Heart Diseases; Heart Valve D

1972
Release of adenosine from human hearts during angina induced by rapid atrial pacing.
    The Journal of clinical investigation, 1974, Volume: 53, Issue:5

    Topics: Adenosine; Adult; Aged; Angina Pectoris; Animals; Arteriosclerosis; Coronary Disease; Creatine; Crea

1974
The effect of tube feeding on the hydration of elderly patients.
    Journal of gerontology, 1965, Volume: 20, Issue:4

    Topics: Aged; Anuria; Blood Urea Nitrogen; Cerebrovascular Disorders; Chemistry Techniques, Analytical; Coro

1965
[Functional changes in the heart in experimental microcirculatory disorders].
    Kardiologiia, 1971, Volume: 11, Issue:11

    Topics: Adenine Nucleotides; Adenosine Diphosphate; Adenosine Monophosphate; Adenosine Triphosphate; Animals

1971
[Treatment of patients with coronary insufficiency with creatinol-o-phosphate].
    Minerva medica, 1968, Apr-11, Volume: 59, Issue:29

    Topics: Coronary Disease; Creatine; Female; Humans; Male; Phosphates

1968
[Enzyme activities, energy phosphates and noradrenaline content in the isolated ischemic guinea pig myocardium].
    Zeitschrift fur die gesamte experimentelle Medizin einschliesslich experimentelle Chirurgie, 1968, Volume: 147, Issue:4

    Topics: Adenine Nucleotides; Adenosine Triphosphate; Animals; Coronary Disease; Creatine; Enzymes; Guinea Pi

1968
[Effect of oxyfedrine on the enzymatic activity and on energy rich phosphates of isolated ischemic guinea pig heart].
    Arzneimittel-Forschung, 1969, Volume: 19, Issue:3

    Topics: Adenine Nucleotides; Adenosine Triphosphate; Animals; Coronary Disease; Creatine; Depression, Chemic

1969