Page last updated: 2024-10-17

creatine and Cognition Disorders

creatine has been researched along with Cognition Disorders in 100 studies

Cognition Disorders: Disorders characterized by disturbances in mental processes related to learning, thinking, reasoning, and judgment.

Research Excerpts

ExcerptRelevanceReference
"Our objective was to investigate the influence of hypertension on N-acetylaspartate (NAA) and choline (Cho) ratios in brain tissues in a community-dwelling elderly population."7.74N-acetylaspartate/creatine and choline/creatine ratios in the thalami, insular cortex and white matter as markers of hypertension and cognitive impairment in the elderly. ( Aho, SL; Bejot, Y; Ben Salem, D; Brunotte, F; Ricolfi, F; Rouaud, O; Tavernier, B; Walker, PM, 2008)
"Seventy-one-year-old identical twin brothers with chronic lead poisoning were identified from an occupational medicine clinic roster."7.72Cognitive deficits and magnetic resonance spectroscopy in adult monozygotic twins with lead poisoning. ( Aro, A; Hu, H; Mulkern, RV; Oliveira, S; Weisskopf, MG; White, R; Wright, RO, 2004)
"A diet rich in B-group vitamins is essential for optimal body and brain function, and insufficient amounts of such vitamins have been associated with higher levels of neural inflammation and oxidative stress, as marked by increased blood plasma homocysteine."5.27The Effect of a High-Dose Vitamin B Multivitamin Supplement on the Relationship between Brain Metabolism and Blood Biomarkers of Oxidative Stress: A Randomized Control Trial. ( Downey, LA; Ford, TC; McPhee, G; Oliver, C; Simpson, T; Stough, C, 2018)
" Neuroimaging measures were central (ventricular) cerebral atrophy, lesion volume, and ratios of N-acetyl aspartate (NAA) to both creatine and choline."5.10Cognitive performance and MR markers of cerebral injury in cognitively impaired MS patients. ( Christodoulou, C; Huang, W; Krupp, LB; Li, L; Li, X; Liang, Z; MacAllister, WS; Melville, P; Morgan, T; Peyster, R; Roche, P; Roque, C; Scherl, WF; Tudorica, LA, 2003)
"Creatine Transporter Deficiency (CTD) is an inborn error of metabolism presenting with intellectual disability, behavioral disturbances and epilepsy."3.96Cyclocreatine treatment ameliorates the cognitive, autistic and epileptic phenotype in a mouse model of Creatine Transporter Deficiency. ( Alessandrì, MG; Baroncelli, L; Battini, R; Butt, M; Cacciante, F; Cerri, E; Cioni, G; Do, MT; Gennaro, M; Lupori, L; Mazziotti, R; McKew, JC; Pizzorusso, T; Putignano, E; Sagona, G, 2020)
"We found lower GABA+/creatine in PD with visual hallucinations (0."3.88Reduced occipital GABA in Parkinson disease with visual hallucinations. ( Allan, CL; Blamire, AM; Collerton, D; Firbank, MJ; Killen, A; Murphy, N; Parikh, J; Taylor, JP, 2018)
"The NAA/Cr (N-acetyl aspartate/creatine) of the bilateral hippocampus of the cognitive impairment group was lower than those of both control group of stroke and health (p < 0."3.85Study on the clinical application of the MRS in the cognitive assessment after stroke. ( Chen, W; Gong, ZK; Sheng, C; Wang, M; Wang, SY; Wang, XX, 2017)
"目的:应用磁共振氢质子波谱(1H-proton magnetic resonance spectroscopy,1H-MRS)检测合并认知功能障碍的多系统萎缩(multiple system atrophy,MSA)患者双侧额叶的代谢特点。方法:收集23例合并认知功能障碍的MSA患者(研究组1)及19例认知功能正常的MSA患者(研究组2),另选48名与两组MSA患者年龄、性别匹配的正常人(正常对照组)均进行1H-MRS检查,其包括双侧额叶区N-乙酰天门冬氨酸(N-acetylaspartate,NAA)/肌酸(creatine,Cr)、胆碱(choline,Cho)/肌酸(Cr)、肌醇(myoinositol,mI)/肌酸(Cr)的测定。结果:合并认知障碍的MSA患者双侧额叶NAA/Cr值较认知正常的MSA患者和正常对照组显著降低(P<0."3.81[1H-proton magnetic resonance spectroscopy in patients with multiple system atrophy and 
cognitive dysfunction]. ( Hou, X; Jiang, H; Sun, Z; Tang, B; Xiang, X; Zhou, G, 2015)
" A 61-year-old man presented with severe cognitive dysfunction after long-term methadone treatment for intercostal neuralgia and was diagnosed with GH insufficiency by GH releasing hormone-arginine testing."3.80Recombinant human growth hormone improves cognitive capacity in a pain patient exposed to chronic opioids. ( Gordh, T; Grönbladh, A; Nyberg, F; Ortiz-Nieto, F; Raininko, R; Rhodin, A; Skottheim, B; von Ehren, M, 2014)
"Our objective was to investigate the influence of hypertension on N-acetylaspartate (NAA) and choline (Cho) ratios in brain tissues in a community-dwelling elderly population."3.74N-acetylaspartate/creatine and choline/creatine ratios in the thalami, insular cortex and white matter as markers of hypertension and cognitive impairment in the elderly. ( Aho, SL; Bejot, Y; Ben Salem, D; Brunotte, F; Ricolfi, F; Rouaud, O; Tavernier, B; Walker, PM, 2008)
"Seventy-one-year-old identical twin brothers with chronic lead poisoning were identified from an occupational medicine clinic roster."3.72Cognitive deficits and magnetic resonance spectroscopy in adult monozygotic twins with lead poisoning. ( Aro, A; Hu, H; Mulkern, RV; Oliveira, S; Weisskopf, MG; White, R; Wright, RO, 2004)
"Creatine is a naturally occurring compound involved in the buffering, transport, and regulation of cellular energy, with the potential to replenish cellular adenosine triphosphate without oxygen."2.80Creatine supplementation enhances corticomotor excitability and cognitive performance during oxygen deprivation. ( Byblow, WD; Gant, N; Turner, CE, 2015)
"Dementia was an independent predictor of metabolite values."2.73Magnetic resonance spectroscopy performance for detection of dementia, Alzheimer's disease and mild cognitive impairment in a community-based survey. ( Antúnez, C; Carles, R; Fortuna, L; García Santos, JM; Gavrila, D; Jiménez Veiga, J; Navarro, C; Parrilla, G; Salmerón, D; Tormo, MJ; Torres del Río, S, 2008)
" Group 1 (n = 15) were given 5 g four times a day of placebo for 1 week, followed by the same dosage of creatine for the second week."2.73Creatine supplementation and cognitive performance in elderly individuals. ( Harris, RC; Howard, A; McMorris, T; Mielcarz, G; Swain, JP, 2007)
"Markers of nocturnal hypoxemia and SDB are associated with cerebral oxidative stress in older people at-risk for dementia, suggesting a potential mechanism by which SDB may contribute to brain degeneration, cognitive decline, and dementia."1.43Association of Anterior Cingulate Glutathione with Sleep Apnea in Older Adults At-Risk for Dementia. ( Cross, N; Duffy, SL; Grunstein, R; Hermens, DF; Hickie, IB; Lagopoulos, J; Lewis, SJ; Mowszowski, L; Naismith, SL; Terpening, Z, 2016)
"Eighty six patients with Type 2 diabetes mellitus (T2DM) were enrolled for this study."1.43[Correlation between cognitive impairment and diabetic nephropathy in patients with Type 2 diabetes mellitus]. ( Niu, H; Shen, J; Shi, X; Wang, R; Wang, S; Wu, J; Yang, H; Zhang, Y; Zhou, S, 2016)
"Increasing evidence suggest that Alzheimer's disease (AD) is a heterogeneous disorder that includes several subtypes with different etiology and progression."1.40Decreased cerebrospinal fluid levels of L-carnitine in non-apolipoprotein E4 carriers at early stages of Alzheimer's disease. ( Cedazo-Mínguez, Á; Cifuentes, A; Ibáñez, C; Lodeiro, M; Simó, C, 2014)
"Patients with advanced Parkinson's disease (PD) commonly suffer with significant executive dysfunction and concomitant visual hallucinations."1.38Anterior cingulate integrity: executive and neuropsychiatric features in Parkinson's disease. ( Duffy, S; Halliday, G; Lewis, SJ; Naismith, SL; Shine, JM, 2012)
"The cognitive decline in Alzheimer's disease (AD) patients has been reported to involve alterations in the medial temporal lobe and the posterior cingulate gyrus."1.34A decrease in N-acetylaspartate and an increase in myoinositol in the anterior cingulate gyrus are associated with behavioral and psychological symptoms in Alzheimer's disease. ( Horiguchi, J; Inagaki, T; Inami, Y; Kawamukai, T; Miyaoka, T; Okazaki, S; Shinno, H; Utani, E, 2007)
"Given the available therapies for Alzheimer's disease, early diagnosis is of paramount importance."1.33Conversion from mild cognitive impairment to probable Alzheimer's disease predicted by brain magnetic resonance spectroscopy. ( Fayed, N; Modrego, PJ; Pina, MA, 2005)

Research

Studies (100)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's6 (6.00)18.2507
2000's47 (47.00)29.6817
2010's46 (46.00)24.3611
2020's1 (1.00)2.80

Authors

AuthorsStudies
Cacciante, F1
Gennaro, M1
Sagona, G1
Mazziotti, R1
Lupori, L1
Cerri, E1
Putignano, E1
Butt, M1
Do, MT1
McKew, JC1
Alessandrì, MG1
Battini, R1
Cioni, G1
Pizzorusso, T1
Baroncelli, L1
Wang, SY1
Wang, M1
Wang, XX1
Chen, W2
Sheng, C1
Gong, ZK1
Zhang, W1
Gu, GJ1
Zhang, Q2
Liu, JH1
Zhang, B2
Guo, Y1
Wang, MY1
Gong, QY1
Xu, JR1
Firbank, MJ1
Parikh, J1
Murphy, N1
Killen, A1
Allan, CL1
Collerton, D1
Blamire, AM1
Taylor, JP1
Ford, TC1
Downey, LA1
Simpson, T1
McPhee, G1
Oliver, C1
Stough, C1
Gasparovic, C2
Prestopnik, J1
Thompson, J1
Taheri, S1
Huisa, B1
Schrader, R1
Adair, JC1
Rosenberg, GA1
Hautman, ER1
Kokenge, AN1
Udobi, KC1
Williams, MT1
Vorhees, CV1
Skelton, MR1
Bayer-Karpinska, A1
Schwarz, F1
Wollenweber, FA1
Poppert, H1
Boeckh-Behrens, T1
Becker, A1
Clevert, DA1
Nikolaou, K1
Opherk, C1
Dichgans, M1
Saam, T1
Sivák, Š1
Bittšanský, M1
Grossmann, J1
Nosál', V1
Kantorová, E1
Siváková, J1
Demková, A1
Hnilicová, P1
Dobrota, D1
Kurča, E1
McCusker, EA1
Myers, RH1
Rosas, HD1
Doros, G1
Gevorkian, S1
Malarick, K1
Reuter, M1
Coutu, JP1
Triggs, TD1
Wilkens, PJ1
Matson, W1
Salat, DH1
Hersch, SM1
Lodeiro, M1
Ibáñez, C1
Cifuentes, A1
Simó, C1
Cedazo-Mínguez, Á1
Ma, Y1
Zhan, M1
OuYang, L1
Li, Y1
Chen, S1
Wu, J2
Chen, J1
Luo, C1
Lei, W1
Rhodin, A1
von Ehren, M1
Skottheim, B1
Grönbladh, A1
Ortiz-Nieto, F1
Raininko, R1
Gordh, T1
Nyberg, F1
Wang, Y2
Li, D1
Bao, F1
Ma, S1
Guo, C1
Jin, C1
Zhang, M1
Markakis, I1
Alexopoulos, H1
Poulopoulou, C1
Akrivou, S1
Papathanasiou, A1
Katsiva, V1
Lyrakos, G1
Gekas, G1
Dalakas, MC1
Fayed, N2
Andrés, E1
Viguera, L1
Modrego, PJ2
Garcia-Campayo, J1
Penner, J1
Wells, JL1
Borrie, MJ1
Woolmore-Goodwin, SM1
Bartha, R1
Wataya, T1
Ishizaki, R1
Kitagawa, M1
Tashiro, Y1
Turner, CE1
Byblow, WD1
Gant, N1
Engl, E1
Garvert, MM1
Xiang, X1
Hou, X1
Sun, Z1
Zhou, G1
Tang, B1
Jiang, H1
Duffy, SL2
Lagopoulos, J2
Cockayne, N1
Lewis, SJ3
Hickie, IB2
Hermens, DF2
Naismith, SL3
Guo, Z1
Zhang, J1
Liu, X2
Hou, H1
Cao, Y1
Wei, F1
Li, J1
Chen, X1
Shen, Y1
Terpening, Z1
Grunstein, R1
Mowszowski, L1
Cross, N1
Shi, X1
Zhang, Y1
Niu, H1
Wang, R1
Shen, J1
Zhou, S1
Yang, H1
Wang, S1
Van Dalen, YW1
Blokhuis, C1
Cohen, S1
Ter Stege, JA1
Teunissen, CE1
Kuhle, J1
Kootstra, NA1
Scherpbier, HJ1
Kuijpers, TW1
Reiss, P1
Majoie, CBLM1
Caan, MWA1
Pajkrt, D1
García Santos, JM1
Gavrila, D1
Antúnez, C1
Tormo, MJ1
Salmerón, D1
Carles, R1
Jiménez Veiga, J1
Parrilla, G1
Torres del Río, S1
Fortuna, L1
Navarro, C1
Paul, RH1
Ernst, T1
Brickman, AM1
Yiannoutsos, CT1
Tate, DF1
Cohen, RA1
Navia, BA1
Ben Salem, D1
Walker, PM1
Bejot, Y1
Aho, SL1
Tavernier, B1
Rouaud, O1
Ricolfi, F1
Brunotte, F1
Kantarci, K5
Petersen, RC5
Przybelski, SA2
Weigand, SD3
Shiung, MM2
Whitwell, JL2
Negash, S2
Ivnik, RJ4
Boeve, BF5
Knopman, DS4
Smith, GE4
Jack, CR5
Erichsen, AK1
Server, A1
Landrø, NI1
Sandvik, L1
Tallaksen, CM1
Wang, Z1
Zhao, C1
Yu, L1
Zhou, W1
Li, K1
Kondziella, D1
Danielsen, ER1
Hansen, K1
Thomsen, C1
Jansen, EC1
Arlien-Soeborg, P1
Li, M2
Sun, ZZ1
Zhu, B1
Yuan, L1
Xu, Y1
Yeo, R1
Mannell, M1
Ling, J1
Elgie, R1
Phillips, J1
Doezema, D1
Mayer, AR1
Filley, CM1
Kozora, E1
Brown, MS1
Miller, DE1
West, SG1
Arciniegas, DB1
Grimm, A1
Zhang, L1
O'Brien, PC3
Pilatus, U1
Lais, C1
Rochmont, Adu M1
Kratzsch, T1
Frölich, L1
Maurer, K1
Zanella, FE1
Lanfermann, H2
Pantel, J1
Tiehuis, A1
van der Meer, F1
Mali, W1
Pleizier, M1
Biessels, GJ1
Kappelle, J1
Luijten, P1
Govind, V1
Gold, S1
Kaliannan, K1
Saigal, G1
Falcone, S1
Arheart, KL1
Harris, L1
Jagid, J1
Maudsley, AA1
Buschkuehl, M1
Jaeggi, SM1
Griffith, HR3
Okonkwo, OC1
den Hollander, JA2
Belue, K1
Copeland, J1
Harrell, LE3
Brockington, JC3
Clark, DG1
Marson, DC3
Rao, V1
Munro, CA1
Rosenberg, P1
Ward, J1
Bertrand, M1
Degoankar, M1
Horská, A1
Pham, D1
Yousem, DM1
Barker, PB1
Li, X2
Shao, X1
Wang, N1
Wang, T1
Chen, G1
Zhou, H1
Premkumar, P1
Parbhakar, VA1
Fannon, D1
Lythgoe, D1
Williams, SC1
Kuipers, E1
Kumari, V1
Bokemeyer, M1
Ding, XQ1
Goldbecker, A1
Raab, P1
Heeren, M1
Arvanitis, D1
Tillmann, HL1
Weissenborn, K1
Valayannopoulos, V1
Boddaert, N1
Chabli, A1
Barbier, V1
Desguerre, I1
Philippe, A1
Afenjar, A1
Mazzuca, M1
Cheillan, D1
Munnich, A1
de Keyzer, Y1
Jakobs, C1
Salomons, GS1
de Lonlay, P1
Pattullo, V1
McAndrews, MP1
Damyanovich, A1
Heathcote, EJ1
Seese, RR1
O'Neill, J1
Hudkins, M1
Siddarth, P1
Levitt, J1
Tseng, B1
Wu, KN1
Caplan, R1
Liu, ZY1
Guo, H1
Zhang, XL1
Liu, J1
Qu, HY1
Peng, W1
Bao, YM1
Yin, LL1
Song, YX1
Byrnes, V1
Miller, A1
Lowry, D1
Hill, E1
Weinstein, C1
Alsop, D1
Lenkinski, R1
Afdhal, NH1
Blinkenberg, M1
Mathiesen, HK1
Tscherning, T1
Jønsson, A1
Svarer, C1
Holm, S1
Sellebjerg, F1
Paulson, OB1
Hanson, LG1
Sorensen, PS1
Owen, L1
Sunram-Lea, SI1
Lim, TS1
Hong, YH1
Lee, HY1
Choi, JY1
Kim, HS1
Moon, SY1
Gonzales, MM1
Tarumi, T1
Eagan, DE1
Tanaka, H1
Vaghasia, M1
Haley, AP1
Shine, JM1
Duffy, S1
Halliday, G1
Bai, Z1
Liu, F1
Song, G1
Xu, J1
Chanson, JB1
Echaniz-Laguna, A1
Blanc, F1
Lacour, A1
Ballonzoli, L1
Kremer, S1
Namer, IJ1
Lannes, B1
Tranchant, C1
Vermersch, P1
de Seze, J1
Bakker, FC1
Klijn, CJ1
Jennekens-Schinkel, A1
van der Tweel, I1
van der Grond, J2
van Huffelen, AC1
Tulleken, CA1
Kappelle, LJ2
Weiss, U1
Bacher, R1
Vonbank, H1
Kemmler, G1
Lingg, A1
Marksteiner, J1
Reynolds, G1
Edland, SD1
Tangalos, EG3
Christodoulou, C1
Krupp, LB1
Liang, Z1
Huang, W1
Melville, P1
Roque, C1
Scherl, WF1
Morgan, T1
MacAllister, WS1
Li, L1
Tudorica, LA1
Roche, P1
Peyster, R1
Obergriesser, T1
Ende, G1
Braus, DF1
Henn, FA1
Sparkes, SJ1
MacMaster, FP1
Carrey, NC1
Weisskopf, MG1
Hu, H1
Mulkern, RV1
White, R1
Aro, A1
Oliveira, S1
Wright, RO1
Assini, A1
Cammarata, S1
Vitali, A1
Colucci, M1
Giliberto, L1
Borghi, R1
Inglese, ML1
Volpe, S1
Ratto, S1
Dagna-Bricarelli, F1
Baldo, C1
Argusti, A1
Odetti, P1
Piccini, A1
Tabaton, M1
Frederick, BD1
Lyoo, IK1
Satlin, A1
Ahn, KH1
Kim, MJ1
Yurgelun-Todd, DA1
Cohen, BM1
Renshaw, PF1
Parry, L1
Shores, A1
Rae, C1
Kemp, A1
Waugh, MC1
Chaseling, R1
Joy, P1
Wang, LN1
Wang, W1
Zhang, XH1
Ma, L1
Yin, H1
Li, DJ1
van Zandvoort, MJ1
de Haan, EH1
Pina, MA1
Nelson, JA1
Dou, H1
Ellison, B1
Uberti, M1
Xiong, H1
Anderson, E1
Mellon, M1
Gelbard, HA1
Boska, M1
Gendelman, HE1
Meng, XM1
Zhu, DM1
Ruan, DY1
She, JQ1
Luo, L1
Metastasio, A1
Rinaldi, P1
Tarducci, R2
Mariani, E1
Feliziani, FT1
Cherubini, A2
Pelliccioli, GP2
Gobbi, G2
Senin, U2
Mecocci, P2
Azevedo, D2
Bottino, CM2
Tatsch, M2
Hototian, SR2
Bazzarella, MC2
Castro, CC2
Coplan, JD1
Mathew, SJ1
Mao, X1
Smith, EL1
Hof, PR1
Coplan, PM1
Rosenblum, LA1
Gorman, JM1
Shungu, DC1
Gunter, J1
Reyes, D1
Shiung, M1
Ohrmann, P1
Siegmund, A1
Suslow, T1
Pedersen, A1
Spitzberg, K1
Kersting, A1
Rothermundt, M1
Arolt, V1
Heindel, W1
Pfleiderer, B1
Ross, AJ1
Sachdev, PS1
Wen, W1
Brodaty, H1
Joscelyne, A1
Lorentz, LM1
Stewart, CC1
Evanochko, WT2
Buchthal, SD1
Zamrini, EY2
Shinno, H1
Inagaki, T1
Miyaoka, T1
Okazaki, S1
Kawamukai, T1
Utani, E1
Inami, Y1
Horiguchi, J1
Hollander, JA1
Okonkwo, O1
Rami, L2
Gómez-Ansón, B2
Bosch, B2
Sánchez-Valle, R2
Monte, GC2
Villar, A1
Molinuevo, JL2
McMorris, T1
Mielcarz, G1
Harris, RC1
Swain, JP1
Howard, A1
Caprile, C1
Purdon, SE1
Valiakalayil, A1
Hanstock, CC1
Seres, P1
Tibbo, P1
Buckley, PF1
Moore, C1
Long, H1
Larkin, C1
Thompson, P1
Mulvany, F1
Redmond, O1
Stack, JP1
Ennis, JT1
Waddington, JL1
Meyerhoff, DJ1
MacKay, S1
Bachman, L1
Poole, N1
Dillon, WP1
Weiner, MW1
Fein, G1
Cecil, KM1
Hills, EC1
Sandel, ME1
Smith, DH1
McIntosh, TK1
Mannon, LJ1
Sinson, GP1
Bagley, LJ1
Grossman, RI1
Lenkinski, RE1
Brooks, WM1
Jung, RE1
Ford, CC1
Greinel, EJ1
Sibbitt, WL1
Foong, J1
Rozewicz, L1
Davie, CA1
Thompson, AJ1
Miller, DH1
Ron, MA1
Martin, RC1
Sawrie, S1
Hugg, J1
Gilliam, F1
Faught, E1
Kuzniecky, R1
Shear, DA1
Haik, KL1
Dunbar, GL1
Xu, YC1
Campeau, NG1
Kokmen, E1
Malloy, CR1
Catani, M1
Howard, R1
Piccirilli, M1
Jessen, F1
Block, W1
Träber, F1
Keller, E1
Flacke, S1
Lamerichs, R1
Schild, HH1
Heun, R1
Forton, DM1
Thomas, HC1
Murphy, CA1
Allsop, JM1
Foster, GR1
Main, J1
Wesnes, KA1
Taylor-Robinson, SD1

Clinical Trials (7)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Carotid Plaque Imaging in Acute Stroke[NCT01284933]234 participants (Actual)Observational2011-02-28Completed
MRI Biomarkers of Risk in Sedentary and Exercise Trained Humans[NCT02729428]71 participants (Actual)Observational2016-04-30Completed
Personalized Medicine in HCV Infection: Cognitive Impairments and Brain Anomalies in Chronic Hepatitis C Infected Individuals. Characterization and Potential Reversibility With Direct Antiviral Agents.[NCT02745132]Phase 480 participants (Anticipated)Interventional2016-06-30Not yet recruiting
A Study of the Cerebral Effect of Pegylated Interferon in Hepatitis C Positive Subjects[NCT00136214]22 participants (Actual)Observational2004-03-31Completed
The Effects of PeakATP (Adenosine 5' - Triphosphate Disodium) Supplementation vs. Placebo on Measures of Mood, Reaction Time and Cognitive Performance[NCT05100589]35 participants (Actual)Interventional2021-10-06Completed
In Vivo Investigation on Mitochondrial Dysfunction in Post-COVID Fatigue and Cancer Fatigue.[NCT05753228]90 participants (Anticipated)Interventional2022-12-09Recruiting
An Open-label Exploratory Study With Memantine: Correlation Between Proton Magnetic Resonance Spectroscopy, Cerebrospinal Fluid Biomarkers, and Cognition in Patients With Mild to Moderate Alzheimer's Disease[NCT00551161]Phase 412 participants (Actual)Interventional2007-08-31Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

Neurocognitive Tests for Cerebral Function

A battery of pen and paper neurocognitive tests where subject means are reported compared to the normative Z score. Data is reported at baseline (T1), week 12 on treatment (T2) and 12 weeks after treatment (week 60, T3). Improvements are increases in the test result compared to baseline as determined against the Z score. tests performed included Hopkins learning trials (HVLT), a measure of of verbal learning and memory and the Roy-Osterrieth Complex figure test (ROCF) which evaluates visio-spatal abilities, memory, planning and working memory. Improvements in the score (increases in value compared, either less negative or more positive to the Z score) shown in the table are reflective of improvements in these neurocognitive parameters. (NCT00136214)
Timeframe: 18 months overall with measures performed at baseline (T1), week 12 (T2) and 12 weeks after end of treatment (T3) with PEG-IFN for 48 weeks which is 60 weeks post baseline and only done in treated group and not controls

,
InterventionZ-score (Mean)
HVLT, Verbal Learning Total, T1HVLT, Verbal Learning Total, T2HVLT, Verbal Learning Total, T3ROCF, T1ROCF, T2ROCF,T3
Interferon Treated Group-1.43-0.78-0.70.340.150.33
Non-treated Cohort Control-2.0-1.16NA-1.00.05NA

Ratios of Cerebral Metabolites Choline (CH), Myoinisitol (MI) and N-acety Aspartate (NAA)to Creatine (Cr) in 3 Brain Regions Including Basal Ganglia, Frontal Cortex and Left Dorsolateral Prefrontal Cortex

Evaluation of changes in MR spectroscopy. reductions in ratio of Cho and MI reflect improvements in cerebral inflammation and improvement in cognition. Increases in the NAA ratio are suggestive of improvement in cognitive function. (NCT00136214)
Timeframe: 18 months overall with measures performed at baseline (T1), week 12 (T2) and 12 weeks after end of treatment (T3) with PEG-IFN for 48 weeks which is 60 weeks post baseline

,
Interventionratio (Mean)
Basal Ganglia, T1, Cho/CrBasal Ganglia,T2, Cho/CrBasal Ganglia, T3, Cho/CrBasal Ganglia, T1, MI/CrBasal Ganglia T2. MI/CBasal Ganglia T3, MI/CFrontal Cortex T1, Cho/CrFrontal Cortex T2, Cho/CrFrontal Cortex T3, Cho/CrBasal Ganglia T1, NAA/CrBasal Ganglia T2, NAA/CrBasal Ganglia T3, NAA/CrFrontal Cortex T1,Mi/CrFrontal Cortex T2, MI/CrFrontal Cortex T3, MI/CrFrontal Cortex T1, NAA/CrFrontal Cortex T2, NAA/CrFrontal Cortex T3, NAA/CrDLPFC T1, Cho/CrDLPFC T2, Cho/CrDLPFC T3, Cho/CrDLPFC T1, MI/CrDLPFC T2, MI/CrDLPFC T3/ MI/CrDLPFC T1, NAA/CrDLPFC T2, NAA/CrDLFPC T3, NAA/Cr
Interferon Treated Group0.420.280.340.780.710.750.290.260.291.261.251.090.680.750.711.731.741.750.310.250.260.790.750.931.721.651.78
Non-treated Cohort Control0.300.28NA0.780.72NA0.280.29NA1.281.07NA0.771.19NA1.551.72NA0.270.27NA0.780.86NA1.611.60NA

Changes in the Metabolite Ratios of N-acetylaspartate (NAA) to Creatine (Cr), Myo-inositol (mI) to Cr, Choline (Cho) to Cr, NAA to Cho, and NAA to mI, on Cholinesterase Monotherapy vs Combination of Memantine and Cholinesterase Inhibitor

Ratios of myo-inositol (mI), N-acetylaspartate (NAA), total creatine (Cr), and choline (Cho) by single voxel 1H MRS (proton magnetic resonance spectroscopy). Mean (± SD) metabolite levels (normalized to T2-corrected water signal intensity) and metabolite ratios for Alzheimer's disease subjects at baseline (t0), after 24 weeks of ongoing monotherapy with stable-dose cholinesterase inhibitor (t1), and after another 24 weeks of combination therapy with memantine in addition to stable-dose cholinesterase inhibitor (t2). The Wilcoxon signed-rank test was used to examine whether the change between t0 and t1 differed from the change between t1 and t2 [(t2 - t1) - (t1 - t0)]. (NCT00551161)
Timeframe: Baseline, 24 weeks, and 48 weeks

Interventionratio (normalized to T2-corrected water (Mean)
Change in NAA [(t2-t1) - (t1-t0)]Change in Cr [(t2-t1) - (t1-t0)]Change in Cho [(t2-t1) - (t1-t0)]Change in mI [(t2-t1) - (t1-t0)]Change in NAA/Cr [(t2-t1) - (t1-t0)]Change in Cho/Cr [(t2-t1) - (t1-t0)]Change in mI/Cr [(t2-t1) - (t1-t0)]Change in NAA/Cho [(t2-t1) - (t1-t0)]Change in NAA/mI [(t2-t1) - (t1-t0)]
Memantine-54-2916-0.090.020.04-0.26-0.35

Reviews

2 reviews available for creatine and Cognition Disorders

ArticleYear
Improving intelligence: a literature review.
    Swiss medical weekly, 2010, Volume: 140, Issue:19-20

    Topics: Achievement; Adolescent; Adult; Aged; Attention Deficit Disorder with Hyperactivity; Central Nervous

2010
Metabolic agents that enhance ATP can improve cognitive functioning: a review of the evidence for glucose, oxygen, pyruvate, creatine, and L-carnitine.
    Nutrients, 2011, Volume: 3, Issue:8

    Topics: Adenosine Triphosphate; Aging; Brain; Carnitine; Cognition; Cognition Disorders; Creatine; Energy Me

2011

Trials

10 trials available for creatine and Cognition Disorders

ArticleYear
The Effect of a High-Dose Vitamin B Multivitamin Supplement on the Relationship between Brain Metabolism and Blood Biomarkers of Oxidative Stress: A Randomized Control Trial.
    Nutrients, 2018, Dec-01, Volume: 10, Issue:12

    Topics: Adult; Aged; Antioxidants; Aspartic Acid; Biomarkers; Brain; Cognition; Cognition Disorders; Creatin

2018
PRECREST: a phase II prevention and biomarker trial of creatine in at-risk Huntington disease.
    Neurology, 2014, Mar-11, Volume: 82, Issue:10

    Topics: Adult; Atrophy; Biomarkers; Brain; Cognition Disorders; Creatine; Cross-Over Studies; Diffusion Magn

2014
Creatine supplementation enhances corticomotor excitability and cognitive performance during oxygen deprivation.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 2015, Jan-28, Volume: 35, Issue:4

    Topics: Adult; Aspartic Acid; Blood Pressure; Cognition Disorders; Creatine; Dietary Supplements; Evoked Pot

2015
The effect of 12-wk ω-3 fatty acid supplementation on in vivo thalamus glutathione concentration in patients "at risk" for major depression.
    Nutrition (Burbank, Los Angeles County, Calif.), 2015, Volume: 31, Issue:10

    Topics: Aged; Aged, 80 and over; Cognition Disorders; Creatine; Depressive Disorder, Major; Dietary Suppleme

2015
Magnetic resonance spectroscopy performance for detection of dementia, Alzheimer's disease and mild cognitive impairment in a community-based survey.
    Dementia and geriatric cognitive disorders, 2008, Volume: 26, Issue:1

    Topics: Aged; Aged, 80 and over; Alzheimer Disease; Aspartic Acid; Brain; Choline; Cognition Disorders; Crea

2008
Effects of anti-viral therapy and HCV clearance on cerebral metabolism and cognition.
    Journal of hepatology, 2012, Volume: 56, Issue:3

    Topics: Adult; Aged; Antiviral Agents; Aspartic Acid; Basal Ganglia; Choline; Cognition; Cognition Disorders

2012
Effects of anti-viral therapy and HCV clearance on cerebral metabolism and cognition.
    Journal of hepatology, 2012, Volume: 56, Issue:3

    Topics: Adult; Aged; Antiviral Agents; Aspartic Acid; Basal Ganglia; Choline; Cognition; Cognition Disorders

2012
Effects of anti-viral therapy and HCV clearance on cerebral metabolism and cognition.
    Journal of hepatology, 2012, Volume: 56, Issue:3

    Topics: Adult; Aged; Antiviral Agents; Aspartic Acid; Basal Ganglia; Choline; Cognition; Cognition Disorders

2012
Effects of anti-viral therapy and HCV clearance on cerebral metabolism and cognition.
    Journal of hepatology, 2012, Volume: 56, Issue:3

    Topics: Adult; Aged; Antiviral Agents; Aspartic Acid; Basal Ganglia; Choline; Cognition; Cognition Disorders

2012
Cognitive impairment is related to cerebral lactate in patients with carotid artery occlusion and ipsilateral transient ischemic attacks.
    Stroke, 2003, Volume: 34, Issue:6

    Topics: Adult; Aged; Aspartic Acid; Blood Flow Velocity; Brain; Carbon Dioxide; Carotid Artery Diseases; Cer

2003
Cognitive performance and MR markers of cerebral injury in cognitively impaired MS patients.
    Neurology, 2003, Jun-10, Volume: 60, Issue:11

    Topics: Adult; Aspartic Acid; Atrophy; Axons; Biomarkers; Cerebral Cortex; Choline; Cognition Disorders; Cre

2003
Creatine supplementation and cognitive performance in elderly individuals.
    Neuropsychology, development, and cognition. Section B, Aging, neuropsychology and cognition, 2007, Volume: 14, Issue:5

    Topics: Aged; Aged, 80 and over; Analysis of Variance; Cognition; Cognition Disorders; Creatine; Cross-Over

2007
Proton spectroscopy in Alzheimer's disease and cognitive impairment no dementia: a community-based study.
    Dementia and geriatric cognitive disorders, 2008, Volume: 25, Issue:6

    Topics: Aged; Aged, 80 and over; Alzheimer Disease; Aspartic Acid; Atrophy; Brain; Choline; Cognition Disord

2008

Other Studies

88 other studies available for creatine and Cognition Disorders

ArticleYear
Cyclocreatine treatment ameliorates the cognitive, autistic and epileptic phenotype in a mouse model of Creatine Transporter Deficiency.
    Scientific reports, 2020, 10-27, Volume: 10, Issue:1

    Topics: Animals; Autistic Disorder; Blood-Brain Barrier; Brain Diseases, Metabolic, Inborn; Cerebrovascular

2020
Study on the clinical application of the MRS in the cognitive assessment after stroke.
    European review for medical and pharmacological sciences, 2017, Volume: 21, Issue:10

    Topics: Aspartic Acid; Cognition; Cognition Disorders; Cognitive Dysfunction; Creatine; Hippocampus; Humans;

2017
NSCs promote hippocampal neurogenesis, metabolic changes and synaptogenesis in APP/PS1 transgenic mice.
    Hippocampus, 2017, Volume: 27, Issue:12

    Topics: Alzheimer Disease; Animals; Aspartic Acid; Cognition Disorders; Creatine; Disease Models, Animal; Gl

2017
Reduced occipital GABA in Parkinson disease with visual hallucinations.
    Neurology, 2018, 08-14, Volume: 91, Issue:7

    Topics: Aged; Aged, 80 and over; Cognition Disorders; Creatine; Female; gamma-Aminobutyric Acid; Gray Matter

2018
1H-MR spectroscopy metabolite levels correlate with executive function in vascular cognitive impairment.
    Journal of neurology, neurosurgery, and psychiatry, 2013, Volume: 84, Issue:7

    Topics: Aged; Aged, 80 and over; Alzheimer Disease; Aspartic Acid; Biomarkers; Brain Ischemia; Choline; Cogn

2013
Female mice heterozygous for creatine transporter deficiency show moderate cognitive deficits.
    Journal of inherited metabolic disease, 2014, Volume: 37, Issue:1

    Topics: Animals; Behavior, Animal; Brain; Brain Diseases, Metabolic, Inborn; Cognition Disorders; Creatine;

2014
The carotid plaque imaging in acute stroke (CAPIAS) study: protocol and initial baseline data.
    BMC neurology, 2013, Dec-13, Volume: 13

    Topics: Aged; Carotid Stenosis; Cerebral Cortex; Cognition Disorders; Cohort Studies; Creatine; Disease Prog

2013
Clinical correlations of proton magnetic resonance spectroscopy findings in acute phase after mild traumatic brain injury.
    Brain injury, 2014, Volume: 28, Issue:3

    Topics: Adult; Aspartic Acid; Biomarkers; Brain Injuries; Cognition Disorders; Creatine; Female; Frontal Lob

2014
Feasibility of Huntington disease trials in the disease prodrome.
    Neurology, 2014, Mar-11, Volume: 82, Issue:10

    Topics: Brain; Cognition Disorders; Creatine; Humans; Huntington Disease

2014
Decreased cerebrospinal fluid levels of L-carnitine in non-apolipoprotein E4 carriers at early stages of Alzheimer's disease.
    Journal of Alzheimer's disease : JAD, 2014, Volume: 41, Issue:1

    Topics: Aged; Alzheimer Disease; Amyloid beta-Peptides; Apolipoprotein E4; Arginine; Biomarkers; Carnitine;

2014
The effects of unilateral 6-OHDA lesion in medial forebrain bundle on the motor, cognitive dysfunctions and vulnerability of different striatal interneuron types in rats.
    Behavioural brain research, 2014, Jun-01, Volume: 266

    Topics: Adrenergic Agents; Animals; Apomorphine; Choline O-Acetyltransferase; Cognition Disorders; Corpus St

2014
Recombinant human growth hormone improves cognitive capacity in a pain patient exposed to chronic opioids.
    Acta anaesthesiologica Scandinavica, 2014, Volume: 58, Issue:6

    Topics: Apoptosis; Arginine; Aspartic Acid; Cognition Disorders; Creatine; Growth Hormone; Growth Hormone-Re

2014
Thalamic metabolic alterations with cognitive dysfunction in idiopathic trigeminal neuralgia: a multivoxel spectroscopy study.
    Neuroradiology, 2014, Volume: 56, Issue:8

    Topics: Adult; Aged; Aspartic Acid; Case-Control Studies; Choline; Cognition Disorders; Creatine; Female; Hu

2014
Immunotherapy-responsive limbic encephalitis with antibodies to glutamic acid decarboxylase.
    Journal of the neurological sciences, 2014, Aug-15, Volume: 343, Issue:1-2

    Topics: Antibodies; Aspartic Acid; Choline; Cognition Disorders; Creatine; Female; Glutamate Decarboxylase;

2014
Higher glutamate+glutamine and reduction of N-acetylaspartate in posterior cingulate according to age range in patients with cognitive impairment and/or pain.
    Academic radiology, 2014, Volume: 21, Issue:9

    Topics: Adult; Age Factors; Aged; Aged, 80 and over; Aspartic Acid; Case-Control Studies; Cognition Disorder

2014
Reduced N-acetylaspartate to creatine ratio in the posterior cingulate correlates with cognition in Alzheimer's disease following four months of rivastigmine treatment.
    Dementia and geriatric cognitive disorders, 2015, Volume: 39, Issue:1-2

    Topics: Aged; Aged, 80 and over; Alzheimer Disease; Aspartic Acid; Cholinesterase Inhibitors; Cognition Diso

2015
Germinoma in the bilateral basal ganglia presented with cognitive deterioration.
    Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery, 2015, Volume: 31, Issue:6

    Topics: Adolescent; Aspartic Acid; Basal Ganglia; Brain Neoplasms; Cognition Disorders; Creatine; Germinoma;

2015
A Prophylactic Role for Creatine in Hypoxia?
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 2015, Jun-24, Volume: 35, Issue:25

    Topics: Cognition Disorders; Creatine; Dietary Supplements; Female; Humans; Hypoxia; Male; Motor Cortex; Neu

2015
[1H-proton magnetic resonance spectroscopy in patients with multiple system atrophy and 
cognitive dysfunction].
    Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences, 2015, Volume: 40, Issue:6

    Topics: Aspartic Acid; Choline; Cognition Disorders; Creatine; Frontal Lobe; Humans; Inositol; Multiple Syst

2015
Neurometabolic characteristics in the anterior cingulate gyrus of Alzheimer's disease patients with depression: a (1)H magnetic resonance spectroscopy study.
    BMC psychiatry, 2015, Dec-02, Volume: 15

    Topics: Aged; Alzheimer Disease; Aspartic Acid; Cognition Disorders; Creatine; Depressive Disorder; Female;

2015
Association of Anterior Cingulate Glutathione with Sleep Apnea in Older Adults At-Risk for Dementia.
    Sleep, 2016, Apr-01, Volume: 39, Issue:4

    Topics: Aged; Aging; Biomarkers; Cognition Disorders; Cognitive Dysfunction; Creatine; Dementia; Depression;

2016
[Correlation between cognitive impairment and diabetic nephropathy in patients with Type 2 diabetes mellitus].
    Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences, 2016, Volume: 41, Issue:2

    Topics: Adult; Aspartic Acid; Case-Control Studies; Cerebrum; Choline; Cognition; Cognition Disorders; Creat

2016
Neurometabolite Alterations Associated With Cognitive Performance in Perinatally HIV-Infected Children.
    Medicine, 2016, Volume: 95, Issue:12

    Topics: Adolescent; AIDS Dementia Complex; Aspartic Acid; Brain; CD4 Lymphocyte Count; Child; Choline; Cogni

2016
Relative sensitivity of magnetic resonance spectroscopy and quantitative magnetic resonance imaging to cognitive function among nondemented individuals infected with HIV.
    Journal of the International Neuropsychological Society : JINS, 2008, Volume: 14, Issue:5

    Topics: Adult; Affect; Aspartic Acid; Choline; Cognition Disorders; Creatine; Female; HIV Infections; Humans

2008
N-acetylaspartate/creatine and choline/creatine ratios in the thalami, insular cortex and white matter as markers of hypertension and cognitive impairment in the elderly.
    Hypertension research : official journal of the Japanese Society of Hypertension, 2008, Volume: 31, Issue:10

    Topics: Aged; Aged, 80 and over; Aging; Aspartic Acid; Biomarkers; Cerebral Cortex; Choline; Cognition Disor

2008
Hippocampal volumes, proton magnetic resonance spectroscopy metabolites, and cerebrovascular disease in mild cognitive impairment subtypes.
    Archives of neurology, 2008, Volume: 65, Issue:12

    Topics: Aged; Aged, 80 and over; Aspartic Acid; Case-Control Studies; Cerebrovascular Disorders; Chi-Square

2008
Proton magnetic resonance spectroscopy and cognition in patients with spastin mutations.
    Journal of the neurological sciences, 2009, Feb-15, Volume: 277, Issue:1-2

    Topics: Adenosine Triphosphatases; Adult; Aspartic Acid; Biomarkers; Choline; Cognition Disorders; Creatine;

2009
Regional metabolic changes in the hippocampus and posterior cingulate area detected with 3-Tesla magnetic resonance spectroscopy in patients with mild cognitive impairment and Alzheimer disease.
    Acta radiologica (Stockholm, Sweden : 1987), 2009, Volume: 50, Issue:3

    Topics: Aged; Aged, 80 and over; Alzheimer Disease; Aspartic Acid; Cognition Disorders; Creatine; Dominance,

2009
1H MR spectroscopy of gray and white matter in carbon monoxide poisoning.
    Journal of neurology, 2009, Volume: 256, Issue:6

    Topics: Adolescent; Adult; Aspartic Acid; Brain; Carbon Monoxide Poisoning; Choline; Cognition Disorders; Cr

2009
Evaluation of functional MRI markers in mild cognitive impairment.
    Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia, 2009, Volume: 16, Issue:5

    Topics: Aged; Aged, 80 and over; Analysis of Variance; Aspartic Acid; Brain; Brain Mapping; Cognition Disord

2009
Neurometabolite concentrations in gray and white matter in mild traumatic brain injury: an 1H-magnetic resonance spectroscopy study.
    Journal of neurotrauma, 2009, Volume: 26, Issue:10

    Topics: Adult; Affective Symptoms; Axons; Biomarkers; Body Water; Brain; Brain Injuries; Cognition Disorders

2009
White matter microstructure and cognition in non-neuropsychiatric systemic lupus erythematosus.
    Cognitive and behavioral neurology : official journal of the Society for Behavioral and Cognitive Neurology, 2009, Volume: 22, Issue:1

    Topics: Adult; Aspartic Acid; Axons; Brain; Brain Chemistry; Choline; Cognition; Cognition Disorders; Creati

2009
Risk of dementia in MCI: combined effect of cerebrovascular disease, volumetric MRI, and 1H MRS.
    Neurology, 2009, Apr-28, Volume: 72, Issue:17

    Topics: Aged; Aged, 80 and over; Aspartic Acid; Atrophy; Biomarkers; Brain; Cerebrovascular Disorders; Cogni

2009
Conversion to dementia in mild cognitive impairment is associated with decline of N-actylaspartate and creatine as revealed by magnetic resonance spectroscopy.
    Psychiatry research, 2009, Jul-15, Volume: 173, Issue:1

    Topics: Aged; Alzheimer Disease; Aspartic Acid; Brain; Choline; Cognition; Cognition Disorders; Creatine; De

2009
MR spectroscopy of cerebral white matter in type 2 diabetes; no association with clinical variables and cognitive performance.
    Neuroradiology, 2010, Volume: 52, Issue:2

    Topics: Aged; Aged, 80 and over; Aspartic Acid; Brain; Choline; Cognition; Cognition Disorders; Creatine; Di

2010
Whole-brain proton MR spectroscopic imaging of mild-to-moderate traumatic brain injury and correlation with neuropsychological deficits.
    Journal of neurotrauma, 2010, Volume: 27, Issue:3

    Topics: Adolescent; Adult; Aspartic Acid; Biomarkers; Brain; Brain Injuries; Choline; Cognition Disorders; C

2010
Brain metabolic correlates of decision making in amnestic mild cognitive impairment.
    Neuropsychology, development, and cognition. Section B, Aging, neuropsychology and cognition, 2010, Volume: 17, Issue:4

    Topics: Aged; Amnesia; Aspartic Acid; Brain; Choline; Cognition Disorders; Creatine; Decision Making; Female

2010
Neuroanatomical correlates of depression in post traumatic brain injury: preliminary results of a pilot study.
    The Journal of neuropsychiatry and clinical neurosciences, 2010,Spring, Volume: 22, Issue:2

    Topics: Adult; Aspartic Acid; Basal Ganglia; Brain; Brain Injuries; Case-Control Studies; Choline; Cognition

2010
Correlation of auditory event-related potentials and magnetic resonance spectroscopy measures in mild cognitive impairment.
    Brain research, 2010, Jul-30, Volume: 1346

    Topics: Acoustic Stimulation; Aged; Aspartic Acid; Brain Chemistry; Cognition Disorders; Creatine; Electroen

2010
N-acetyl aspartate concentration in the anterior cingulate cortex in patients with schizophrenia: a study of clinical and neuropsychological correlates and preliminary exploration of cognitive behaviour therapy effects.
    Psychiatry research, 2010, 06-30, Volume: 182, Issue:3

    Topics: Adolescent; Adult; Analysis of Variance; Aspartic Acid; Child; Choline; Cognition Disorders; Cogniti

2010
Evidence for neuroinflammation and neuroprotection in HCV infection-associated encephalopathy.
    Gut, 2011, Volume: 60, Issue:3

    Topics: Adult; Aged; Aspartic Acid; Brain; Brain Mapping; Case-Control Studies; Choline; Cognition Disorders

2011
Treatment by oral creatine, L-arginine and L-glycine in six severely affected patients with creatine transporter defect.
    Journal of inherited metabolic disease, 2012, Volume: 35, Issue:1

    Topics: Administration, Oral; Adolescent; Amino Acid Transport Disorders, Inborn; Arginine; Child; Child, Pr

2012
Influence of hepatitis C virus on neurocognitive function in patients free from other risk factors: validation from therapeutic outcomes.
    Liver international : official journal of the International Association for the Study of the Liver, 2011, Volume: 31, Issue:7

    Topics: Aspartic Acid; Brain; Cognition Disorders; Cohort Studies; Creatine; Fatigue; Female; Globus Pallidu

2011
Proton magnetic resonance spectroscopy and thought disorder in childhood schizophrenia.
    Schizophrenia research, 2011, Volume: 133, Issue:1-3

    Topics: Adolescent; Analysis of Variance; Aspartic Acid; Brain; Child; Choline; Cognition Disorders; Creatin

2011
[Impacts of electroacupuncture on left hippocampus NAA/Cr for patients of Uygur and Han nationality with mild cognitive impairment].
    Zhongguo zhen jiu = Chinese acupuncture & moxibustion, 2011, Volume: 31, Issue:9

    Topics: Aged; Aged, 80 and over; Aspartic Acid; China; Cognition Disorders; Creatine; Electroacupuncture; Fe

2011
Cerebral metabolism, magnetic resonance spectroscopy and cognitive dysfunction in early multiple sclerosis: an exploratory study.
    Neurological research, 2012, Volume: 34, Issue:1

    Topics: Adult; Aspartic Acid; Brain; Cerebral Cortex; Cognition Disorders; Creatine; Female; Glucose; Humans

2012
Metabolite investigation in both anterior and posterior cingulate gyri in Alzheimer's disease spectrum using 3-tesla MR spectroscopy.
    Dementia and geriatric cognitive disorders, 2012, Volume: 33, Issue:2-3

    Topics: Aged; Aged, 80 and over; Alzheimer Disease; Aspartic Acid; Cognition Disorders; Creatine; Disease Pr

2012
Indirect effects of elevated body mass index on memory performance through altered cerebral metabolite concentrations.
    Psychosomatic medicine, 2012, Volume: 74, Issue:7

    Topics: Adult; Aspartic Acid; Biomarkers; Body Mass Index; Brain; Choline; Cognition Disorders; Creatine; Fe

2012
Anterior cingulate integrity: executive and neuropsychiatric features in Parkinson's disease.
    Movement disorders : official journal of the Movement Disorder Society, 2012, Sep-01, Volume: 27, Issue:10

    Topics: Aged; Aspartic Acid; Case-Control Studies; Cognition Disorders; Creatine; Female; Gyrus Cinguli; Hum

2012
Reduced posterior cingulate glutamate measured by magnetic resonance spectroscopy in hyperthyroidism.
    Neuro endocrinology letters, 2012, Volume: 33, Issue:6

    Topics: Adult; Aspartic Acid; Choline; Cognition Disorders; Creatine; Female; Glutamic Acid; Gyrus Cinguli;

2012
Central nervous system abnormalities in patients with PMP22 gene mutations: a prospective study.
    Journal of neurology, neurosurgery, and psychiatry, 2013, Volume: 84, Issue:4

    Topics: Aged; Aspartic Acid; Brain; Brain Chemistry; Central Nervous System; Cognition Disorders; Cohort Stu

2013
Cognitive impairment: assessment with brain magnetic resonance imaging and proton magnetic resonance spectroscopy.
    The Journal of clinical psychiatry, 2003, Volume: 64, Issue:3

    Topics: Aged; Alzheimer Disease; Aspartic Acid; Brain; Brain Chemistry; Choline; Cognition Disorders; Creati

2003
Proton MR spectroscopy in mild cognitive impairment and Alzheimer disease: comparison of 1.5 and 3 T.
    AJNR. American journal of neuroradiology, 2003, Volume: 24, Issue:5

    Topics: Aged; Aged, 80 and over; Alzheimer Disease; Aspartic Acid; Brain; Choline; Cognition Disorders; Crea

2003
Long-term follow-up of magnetic resonance-detectable choline signal changes in the hippocampus of patients treated with electroconvulsive therapy.
    The Journal of clinical psychiatry, 2003, Volume: 64, Issue:7

    Topics: Aspartic Acid; Choline; Cognition Disorders; Creatine; Depressive Disorder, Major; Electroconvulsive

2003
Proton magnetic resonance spectroscopy and cognitive function in pediatric attention-deficit/hyperactive disorder.
    Brain and cognition, 2004, Volume: 54, Issue:2

    Topics: Aspartic Acid; Attention Deficit Disorder with Hyperactivity; Brain Stem; Child; Choline; Cognition

2004
Cognitive deficits and magnetic resonance spectroscopy in adult monozygotic twins with lead poisoning.
    Environmental health perspectives, 2004, Volume: 112, Issue:5

    Topics: Aged; Aspartic Acid; Bone and Bones; Brain; Cell Count; Cognition Disorders; Creatine; Diseases in T

2004
Plasma levels of amyloid beta-protein 42 are increased in women with mild cognitive impairment.
    Neurology, 2004, Sep-14, Volume: 63, Issue:5

    Topics: Age of Onset; Aged; Alzheimer Disease; Amyloid beta-Peptides; Apolipoproteins E; Biomarkers; Cholest

2004
In vivo proton magnetic resonance spectroscopy of the temporal lobe in Alzheimer's disease.
    Progress in neuro-psychopharmacology & biological psychiatry, 2004, Volume: 28, Issue:8

    Topics: Aged; Aged, 80 and over; Alzheimer Disease; Analysis of Variance; Aspartic Acid; Brain Mapping; Case

2004
An investigation of neuronal integrity in severe paediatric traumatic brain injury.
    Child neuropsychology : a journal on normal and abnormal development in childhood and adolescence, 2004, Volume: 10, Issue:4

    Topics: Adolescent; Age Factors; Aspartic Acid; Brain Injuries; Child; Choline; Cognition Disorders; Creatin

2004
[An interventional study on amnestic mild cognitive impairment with small dose donepezil].
    Zhonghua nei ke za zhi, 2004, Volume: 43, Issue:10

    Topics: Aged; Aged, 80 and over; Amnesia; Aspartic Acid; Cognition; Cognition Disorders; Creatine; Donepezil

2004
Cognitive deficits and changes in neurometabolites after a lacunar infarct.
    Journal of neurology, 2005, Volume: 252, Issue:2

    Topics: Aged; Analysis of Variance; Aspartic Acid; Brain Infarction; Case-Control Studies; Choline; Cognitio

2005
Conversion from mild cognitive impairment to probable Alzheimer's disease predicted by brain magnetic resonance spectroscopy.
    The American journal of psychiatry, 2005, Volume: 162, Issue:4

    Topics: Aged; Alzheimer Disease; Aspartic Acid; Brain; Choline; Cognition Disorders; Cohort Studies; Creatin

2005
Coregistration of quantitative proton magnetic resonance spectroscopic imaging with neuropathological and neurophysiological analyses defines the extent of neuronal impairments in murine human immunodeficiency virus type-1 encephalitis.
    Journal of neuroscience research, 2005, May-15, Volume: 80, Issue:4

    Topics: AIDS Dementia Complex; Animals; Aspartic Acid; Brain Mapping; Calcium-Binding Proteins; Capsid Prote

2005
Effects of chronic lead exposure on 1H MRS of hippocampus and frontal lobes in children.
    Neurology, 2005, May-10, Volume: 64, Issue:9

    Topics: Aspartic Acid; Cell Membrane; Cell Survival; Child; Choline; Chronic Disease; Cognition Disorders; C

2005
Conversion of MCI to dementia: Role of proton magnetic resonance spectroscopy.
    Neurobiology of aging, 2006, Volume: 27, Issue:7

    Topics: Aged; Amnesia; Aspartic Acid; Cerebral Cortex; Choline; Cognition Disorders; Creatine; Dementia; Dis

2006
[Proton spectroscopy in Alzheimer's disease and cognitive impairment not dementia: a community study].
    Arquivos de neuro-psiquiatria, 2005, Volume: 63, Issue:4

    Topics: Aged; Aged, 80 and over; Alzheimer Disease; Aspartic Acid; Case-Control Studies; Choline; Cognition

2005
Decreased choline and creatine concentrations in centrum semiovale in patients with generalized anxiety disorder: relationship to IQ and early trauma.
    Psychiatry research, 2006, Jun-30, Volume: 147, Issue:1

    Topics: Adult; Anxiety Disorders; Body Mass Index; Choline; Cognition Disorders; Creatine; Frontal Lobe; Fun

2006
Longitudinal 1H MRS changes in mild cognitive impairment and Alzheimer's disease.
    Neurobiology of aging, 2007, Volume: 28, Issue:9

    Topics: Aged; Aged, 80 and over; Alzheimer Disease; Analysis of Variance; Aspartic Acid; Choline; Cognition

2007
Cognitive impairment and in vivo metabolites in first-episode neuroleptic-naive and chronic medicated schizophrenic patients: a proton magnetic resonance spectroscopy study.
    Journal of psychiatric research, 2007, Volume: 41, Issue:8

    Topics: Adult; Aged; Antipsychotic Agents; Aspartic Acid; Choline; Chronic Disease; Cognition Disorders; Cre

2007
Prediction of cognitive decline after stroke using proton magnetic resonance spectroscopy.
    Journal of the neurological sciences, 2006, Dec-21, Volume: 251, Issue:1-2

    Topics: Aged; Aged, 80 and over; Analysis of Variance; Aspartic Acid; Brain Chemistry; Cognition Disorders;

2006
Elevated brain scyllo-inositol concentrations in patients with Alzheimer's disease.
    NMR in biomedicine, 2007, Volume: 20, Issue:8

    Topics: Aged; Alzheimer Disease; Aspartic Acid; Biopsy; Brain; Cognition Disorders; Creatine; Female; Humans

2007
A decrease in N-acetylaspartate and an increase in myoinositol in the anterior cingulate gyrus are associated with behavioral and psychological symptoms in Alzheimer's disease.
    Journal of the neurological sciences, 2007, Sep-15, Volume: 260, Issue:1-2

    Topics: Aged; Aged, 80 and over; Alzheimer Disease; Aspartic Acid; Brain Chemistry; Cognition Disorders; Cre

2007
Executive function is associated with brain proton magnetic resonance spectroscopy in amnestic mild cognitive impairment.
    Journal of clinical and experimental neuropsychology, 2007, Volume: 29, Issue:6

    Topics: Aged; Amnesia; Analysis of Variance; Cognition Disorders; Creatine; Female; Gyrus Cinguli; Humans; I

2007
Cortical brain metabolism as measured by proton spectroscopy is related to memory performance in patients with amnestic mild cognitive impairment and Alzheimer's disease.
    Dementia and geriatric cognitive disorders, 2007, Volume: 24, Issue:4

    Topics: Aged; Alzheimer Disease; Amnesia; Aspartic Acid; Cerebral Cortex; Cognition Disorders; Creatine; Fem

2007
Naming is associated with left temporal pole metabolite levels in neurodegenerative diseases.
    Dementia and geriatric cognitive disorders, 2008, Volume: 25, Issue:3

    Topics: Aged; Amnesia; Anomia; Aspartic Acid; Choline; Cognition Disorders; Creatine; Dementia; Female; Huma

2008
Elevated 3T proton MRS glutamate levels associated with poor Continuous Performance Test (CPT-0X) scores and genetic risk for schizophrenia.
    Schizophrenia research, 2008, Volume: 99, Issue:1-3

    Topics: Adult; Attention; Cognition Disorders; Creatine; Discrimination, Psychological; Female; Frontal Lobe

2008
1H-magnetic resonance spectroscopy of the left temporal and frontal lobes in schizophrenia: clinical, neurodevelopmental, and cognitive correlates.
    Biological psychiatry, 1994, Dec-15, Volume: 36, Issue:12

    Topics: Adult; Choline; Cognition Disorders; Creatine; Female; Frontal Lobe; Humans; Magnetic Resonance Spec

1994
Reduced brain N-acetylaspartate suggests neuronal loss in cognitively impaired human immunodeficiency virus-seropositive individuals: in vivo 1H magnetic resonance spectroscopic imaging.
    Neurology, 1993, Volume: 43, Issue:3 Pt 1

    Topics: Adult; Aspartic Acid; Brain; Choline; Cognition Disorders; Creatine; HIV Seropositivity; Humans; Mag

1993
Proton magnetic resonance spectroscopy for detection of axonal injury in the splenium of the corpus callosum of brain-injured patients.
    Journal of neurosurgery, 1998, Volume: 88, Issue:5

    Topics: Acceleration; Accidents, Traffic; Adult; Aged; Aspartic Acid; Axons; Brain Concussion; Brain Disease

1998
Relationship between neurometabolite derangement and neurocognitive dysfunction in systemic lupus erythematosus.
    The Journal of rheumatology, 1999, Volume: 26, Issue:1

    Topics: Adult; Aspartic Acid; Brain; Choline; Cognition Disorders; Creatine; Female; Humans; Lupus Erythemat

1999
Correlates of executive function in multiple sclerosis: the use of magnetic resonance spectroscopy as an index of focal pathology.
    The Journal of neuropsychiatry and clinical neurosciences, 1999,Winter, Volume: 11, Issue:1

    Topics: Adult; Analysis of Variance; Aspartic Acid; Attention; Biomarkers; Case-Control Studies; Chi-Square

1999
Cognitive correlates of 1H MRSI-detected hippocampal abnormalities in temporal lobe epilepsy.
    Neurology, 1999, Dec-10, Volume: 53, Issue:9

    Topics: Adult; Aspartic Acid; Brain Mapping; Cognition Disorders; Creatine; Dominance, Cerebral; Epilepsy, T

1999
Creatine reduces 3-nitropropionic-acid-induced cognitive and motor abnormalities in rats.
    Neuroreport, 2000, Jun-26, Volume: 11, Issue:9

    Topics: Animals; Behavior, Animal; Cerebral Ventricles; Cognition Disorders; Corpus Striatum; Creatine; Male

2000
Regional metabolic patterns in mild cognitive impairment and Alzheimer's disease: A 1H MRS study.
    Neurology, 2000, Jul-25, Volume: 55, Issue:2

    Topics: Aged; Aged, 80 and over; Alzheimer Disease; Aspartic Acid; Brain Mapping; Choline; Cognition Disorde

2000
Correlation of cerebral metabolites with clinical outcome among patients with severe congestive heart failure.
    Circulation, 2001, Jun-12, Volume: 103, Issue:23

    Topics: Aspartic Acid; Brain; Choline; Cognition Disorders; Creatine; Disease Progression; Heart Failure; Hu

2001
(1)H-MR spectroscopy differentiates mild cognitive impairment from normal brain aging.
    Neuroreport, 2001, Aug-08, Volume: 12, Issue:11

    Topics: Aged; Aged, 80 and over; Aging; Alzheimer Disease; Aspartic Acid; Brain Chemistry; Choline; Cognitio

2001
Decrease of N-acetylaspartate in the MTL correlates with cognitive decline of AD patients.
    Neurology, 2001, Sep-11, Volume: 57, Issue:5

    Topics: Aged; Alzheimer Disease; Aspartic Acid; Cognition Disorders; Creatine; Cross-Sectional Studies; Fema

2001
Hepatitis C and cognitive impairment in a cohort of patients with mild liver disease.
    Hepatology (Baltimore, Md.), 2002, Volume: 35, Issue:2

    Topics: Adult; Aged; Brain; Choline; Cognition Disorders; Cohort Studies; Creatine; Female; Hepatitis C; Hum

2002