creatine has been researched along with Cognition Disorders in 100 studies
Cognition Disorders: Disorders characterized by disturbances in mental processes related to learning, thinking, reasoning, and judgment.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Our objective was to investigate the influence of hypertension on N-acetylaspartate (NAA) and choline (Cho) ratios in brain tissues in a community-dwelling elderly population." | 7.74 | N-acetylaspartate/creatine and choline/creatine ratios in the thalami, insular cortex and white matter as markers of hypertension and cognitive impairment in the elderly. ( Aho, SL; Bejot, Y; Ben Salem, D; Brunotte, F; Ricolfi, F; Rouaud, O; Tavernier, B; Walker, PM, 2008) |
| "Seventy-one-year-old identical twin brothers with chronic lead poisoning were identified from an occupational medicine clinic roster." | 7.72 | Cognitive deficits and magnetic resonance spectroscopy in adult monozygotic twins with lead poisoning. ( Aro, A; Hu, H; Mulkern, RV; Oliveira, S; Weisskopf, MG; White, R; Wright, RO, 2004) |
| "A diet rich in B-group vitamins is essential for optimal body and brain function, and insufficient amounts of such vitamins have been associated with higher levels of neural inflammation and oxidative stress, as marked by increased blood plasma homocysteine." | 5.27 | The Effect of a High-Dose Vitamin B Multivitamin Supplement on the Relationship between Brain Metabolism and Blood Biomarkers of Oxidative Stress: A Randomized Control Trial. ( Downey, LA; Ford, TC; McPhee, G; Oliver, C; Simpson, T; Stough, C, 2018) |
| " Neuroimaging measures were central (ventricular) cerebral atrophy, lesion volume, and ratios of N-acetyl aspartate (NAA) to both creatine and choline." | 5.10 | Cognitive performance and MR markers of cerebral injury in cognitively impaired MS patients. ( Christodoulou, C; Huang, W; Krupp, LB; Li, L; Li, X; Liang, Z; MacAllister, WS; Melville, P; Morgan, T; Peyster, R; Roche, P; Roque, C; Scherl, WF; Tudorica, LA, 2003) |
| "Creatine Transporter Deficiency (CTD) is an inborn error of metabolism presenting with intellectual disability, behavioral disturbances and epilepsy." | 3.96 | Cyclocreatine treatment ameliorates the cognitive, autistic and epileptic phenotype in a mouse model of Creatine Transporter Deficiency. ( Alessandrì, MG; Baroncelli, L; Battini, R; Butt, M; Cacciante, F; Cerri, E; Cioni, G; Do, MT; Gennaro, M; Lupori, L; Mazziotti, R; McKew, JC; Pizzorusso, T; Putignano, E; Sagona, G, 2020) |
| "We found lower GABA+/creatine in PD with visual hallucinations (0." | 3.88 | Reduced occipital GABA in Parkinson disease with visual hallucinations. ( Allan, CL; Blamire, AM; Collerton, D; Firbank, MJ; Killen, A; Murphy, N; Parikh, J; Taylor, JP, 2018) |
| "The NAA/Cr (N-acetyl aspartate/creatine) of the bilateral hippocampus of the cognitive impairment group was lower than those of both control group of stroke and health (p < 0." | 3.85 | Study on the clinical application of the MRS in the cognitive assessment after stroke. ( Chen, W; Gong, ZK; Sheng, C; Wang, M; Wang, SY; Wang, XX, 2017) |
| "目的：应用磁共振氢质子波谱(1H-proton magnetic resonance spectroscopy，1H-MRS)检测合并认知功能障碍的多系统萎缩(multiple system atrophy，MSA)患者双侧额叶的代谢特点。方法：收集23例合并认知功能障碍的MSA患者(研究组1)及19例认知功能正常的MSA患者(研究组2)，另选48名与两组MSA患者年龄、性别匹配的正常人(正常对照组)均进行1H-MRS检查，其包括双侧额叶区N-乙酰天门冬氨酸(N-acetylaspartate，NAA)/肌酸(creatine，Cr)、胆碱(choline，Cho)/肌酸(Cr)、肌醇(myoinositol，mI)/肌酸(Cr)的测定。结果：合并认知障碍的MSA患者双侧额叶NAA/Cr值较认知正常的MSA患者和正常对照组显著降低(P<0." | 3.81 | [1H-proton magnetic resonance spectroscopy in patients with multiple system atrophy and cognitive dysfunction]. ( Hou, X; Jiang, H; Sun, Z; Tang, B; Xiang, X; Zhou, G, 2015) |
| " A 61-year-old man presented with severe cognitive dysfunction after long-term methadone treatment for intercostal neuralgia and was diagnosed with GH insufficiency by GH releasing hormone-arginine testing." | 3.80 | Recombinant human growth hormone improves cognitive capacity in a pain patient exposed to chronic opioids. ( Gordh, T; Grönbladh, A; Nyberg, F; Ortiz-Nieto, F; Raininko, R; Rhodin, A; Skottheim, B; von Ehren, M, 2014) |
| "Our objective was to investigate the influence of hypertension on N-acetylaspartate (NAA) and choline (Cho) ratios in brain tissues in a community-dwelling elderly population." | 3.74 | N-acetylaspartate/creatine and choline/creatine ratios in the thalami, insular cortex and white matter as markers of hypertension and cognitive impairment in the elderly. ( Aho, SL; Bejot, Y; Ben Salem, D; Brunotte, F; Ricolfi, F; Rouaud, O; Tavernier, B; Walker, PM, 2008) |
| "Seventy-one-year-old identical twin brothers with chronic lead poisoning were identified from an occupational medicine clinic roster." | 3.72 | Cognitive deficits and magnetic resonance spectroscopy in adult monozygotic twins with lead poisoning. ( Aro, A; Hu, H; Mulkern, RV; Oliveira, S; Weisskopf, MG; White, R; Wright, RO, 2004) |
| "Creatine is a naturally occurring compound involved in the buffering, transport, and regulation of cellular energy, with the potential to replenish cellular adenosine triphosphate without oxygen." | 2.80 | Creatine supplementation enhances corticomotor excitability and cognitive performance during oxygen deprivation. ( Byblow, WD; Gant, N; Turner, CE, 2015) |
| "Dementia was an independent predictor of metabolite values." | 2.73 | Magnetic resonance spectroscopy performance for detection of dementia, Alzheimer's disease and mild cognitive impairment in a community-based survey. ( Antúnez, C; Carles, R; Fortuna, L; García Santos, JM; Gavrila, D; Jiménez Veiga, J; Navarro, C; Parrilla, G; Salmerón, D; Tormo, MJ; Torres del Río, S, 2008) |
| " Group 1 (n = 15) were given 5 g four times a day of placebo for 1 week, followed by the same dosage of creatine for the second week." | 2.73 | Creatine supplementation and cognitive performance in elderly individuals. ( Harris, RC; Howard, A; McMorris, T; Mielcarz, G; Swain, JP, 2007) |
| "Markers of nocturnal hypoxemia and SDB are associated with cerebral oxidative stress in older people at-risk for dementia, suggesting a potential mechanism by which SDB may contribute to brain degeneration, cognitive decline, and dementia." | 1.43 | Association of Anterior Cingulate Glutathione with Sleep Apnea in Older Adults At-Risk for Dementia. ( Cross, N; Duffy, SL; Grunstein, R; Hermens, DF; Hickie, IB; Lagopoulos, J; Lewis, SJ; Mowszowski, L; Naismith, SL; Terpening, Z, 2016) |
| "Eighty six patients with Type 2 diabetes mellitus (T2DM) were enrolled for this study." | 1.43 | [Correlation between cognitive impairment and diabetic nephropathy in patients with Type 2 diabetes mellitus]. ( Niu, H; Shen, J; Shi, X; Wang, R; Wang, S; Wu, J; Yang, H; Zhang, Y; Zhou, S, 2016) |
| "Increasing evidence suggest that Alzheimer's disease (AD) is a heterogeneous disorder that includes several subtypes with different etiology and progression." | 1.40 | Decreased cerebrospinal fluid levels of L-carnitine in non-apolipoprotein E4 carriers at early stages of Alzheimer's disease. ( Cedazo-Mínguez, Á; Cifuentes, A; Ibáñez, C; Lodeiro, M; Simó, C, 2014) |
| "Patients with advanced Parkinson's disease (PD) commonly suffer with significant executive dysfunction and concomitant visual hallucinations." | 1.38 | Anterior cingulate integrity: executive and neuropsychiatric features in Parkinson's disease. ( Duffy, S; Halliday, G; Lewis, SJ; Naismith, SL; Shine, JM, 2012) |
| "The cognitive decline in Alzheimer's disease (AD) patients has been reported to involve alterations in the medial temporal lobe and the posterior cingulate gyrus." | 1.34 | A decrease in N-acetylaspartate and an increase in myoinositol in the anterior cingulate gyrus are associated with behavioral and psychological symptoms in Alzheimer's disease. ( Horiguchi, J; Inagaki, T; Inami, Y; Kawamukai, T; Miyaoka, T; Okazaki, S; Shinno, H; Utani, E, 2007) |
| "Given the available therapies for Alzheimer's disease, early diagnosis is of paramount importance." | 1.33 | Conversion from mild cognitive impairment to probable Alzheimer's disease predicted by brain magnetic resonance spectroscopy. ( Fayed, N; Modrego, PJ; Pina, MA, 2005) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 6 (6.00) | 18.2507 |
| 2000's | 47 (47.00) | 29.6817 |
| 2010's | 46 (46.00) | 24.3611 |
| 2020's | 1 (1.00) | 2.80 |
| Authors | Studies |
|---|---|
| Cacciante, F | 1 |
| Gennaro, M | 1 |
| Sagona, G | 1 |
| Mazziotti, R | 1 |
| Lupori, L | 1 |
| Cerri, E | 1 |
| Putignano, E | 1 |
| Butt, M | 1 |
| Do, MT | 1 |
| McKew, JC | 1 |
| Alessandrì, MG | 1 |
| Battini, R | 1 |
| Cioni, G | 1 |
| Pizzorusso, T | 1 |
| Baroncelli, L | 1 |
| Wang, SY | 1 |
| Wang, M | 1 |
| Wang, XX | 1 |
| Chen, W | 2 |
| Sheng, C | 1 |
| Gong, ZK | 1 |
| Zhang, W | 1 |
| Gu, GJ | 1 |
| Zhang, Q | 2 |
| Liu, JH | 1 |
| Zhang, B | 2 |
| Guo, Y | 1 |
| Wang, MY | 1 |
| Gong, QY | 1 |
| Xu, JR | 1 |
| Firbank, MJ | 1 |
| Parikh, J | 1 |
| Murphy, N | 1 |
| Killen, A | 1 |
| Allan, CL | 1 |
| Collerton, D | 1 |
| Blamire, AM | 1 |
| Taylor, JP | 1 |
| Ford, TC | 1 |
| Downey, LA | 1 |
| Simpson, T | 1 |
| McPhee, G | 1 |
| Oliver, C | 1 |
| Stough, C | 1 |
| Gasparovic, C | 2 |
| Prestopnik, J | 1 |
| Thompson, J | 1 |
| Taheri, S | 1 |
| Huisa, B | 1 |
| Schrader, R | 1 |
| Adair, JC | 1 |
| Rosenberg, GA | 1 |
| Hautman, ER | 1 |
| Kokenge, AN | 1 |
| Udobi, KC | 1 |
| Williams, MT | 1 |
| Vorhees, CV | 1 |
| Skelton, MR | 1 |
| Bayer-Karpinska, A | 1 |
| Schwarz, F | 1 |
| Wollenweber, FA | 1 |
| Poppert, H | 1 |
| Boeckh-Behrens, T | 1 |
| Becker, A | 1 |
| Clevert, DA | 1 |
| Nikolaou, K | 1 |
| Opherk, C | 1 |
| Dichgans, M | 1 |
| Saam, T | 1 |
| Sivák, Š | 1 |
| Bittšanský, M | 1 |
| Grossmann, J | 1 |
| Nosál', V | 1 |
| Kantorová, E | 1 |
| Siváková, J | 1 |
| Demková, A | 1 |
| Hnilicová, P | 1 |
| Dobrota, D | 1 |
| Kurča, E | 1 |
| McCusker, EA | 1 |
| Myers, RH | 1 |
| Rosas, HD | 1 |
| Doros, G | 1 |
| Gevorkian, S | 1 |
| Malarick, K | 1 |
| Reuter, M | 1 |
| Coutu, JP | 1 |
| Triggs, TD | 1 |
| Wilkens, PJ | 1 |
| Matson, W | 1 |
| Salat, DH | 1 |
| Hersch, SM | 1 |
| Lodeiro, M | 1 |
| Ibáñez, C | 1 |
| Cifuentes, A | 1 |
| Simó, C | 1 |
| Cedazo-Mínguez, Á | 1 |
| Ma, Y | 1 |
| Zhan, M | 1 |
| OuYang, L | 1 |
| Li, Y | 1 |
| Chen, S | 1 |
| Wu, J | 2 |
| Chen, J | 1 |
| Luo, C | 1 |
| Lei, W | 1 |
| Rhodin, A | 1 |
| von Ehren, M | 1 |
| Skottheim, B | 1 |
| Grönbladh, A | 1 |
| Ortiz-Nieto, F | 1 |
| Raininko, R | 1 |
| Gordh, T | 1 |
| Nyberg, F | 1 |
| Wang, Y | 2 |
| Li, D | 1 |
| Bao, F | 1 |
| Ma, S | 1 |
| Guo, C | 1 |
| Jin, C | 1 |
| Zhang, M | 1 |
| Markakis, I | 1 |
| Alexopoulos, H | 1 |
| Poulopoulou, C | 1 |
| Akrivou, S | 1 |
| Papathanasiou, A | 1 |
| Katsiva, V | 1 |
| Lyrakos, G | 1 |
| Gekas, G | 1 |
| Dalakas, MC | 1 |
| Fayed, N | 2 |
| Andrés, E | 1 |
| Viguera, L | 1 |
| Modrego, PJ | 2 |
| Garcia-Campayo, J | 1 |
| Penner, J | 1 |
| Wells, JL | 1 |
| Borrie, MJ | 1 |
| Woolmore-Goodwin, SM | 1 |
| Bartha, R | 1 |
| Wataya, T | 1 |
| Ishizaki, R | 1 |
| Kitagawa, M | 1 |
| Tashiro, Y | 1 |
| Turner, CE | 1 |
| Byblow, WD | 1 |
| Gant, N | 1 |
| Engl, E | 1 |
| Garvert, MM | 1 |
| Xiang, X | 1 |
| Hou, X | 1 |
| Sun, Z | 1 |
| Zhou, G | 1 |
| Tang, B | 1 |
| Jiang, H | 1 |
| Duffy, SL | 2 |
| Lagopoulos, J | 2 |
| Cockayne, N | 1 |
| Lewis, SJ | 3 |
| Hickie, IB | 2 |
| Hermens, DF | 2 |
| Naismith, SL | 3 |
| Guo, Z | 1 |
| Zhang, J | 1 |
| Liu, X | 2 |
| Hou, H | 1 |
| Cao, Y | 1 |
| Wei, F | 1 |
| Li, J | 1 |
| Chen, X | 1 |
| Shen, Y | 1 |
| Terpening, Z | 1 |
| Grunstein, R | 1 |
| Mowszowski, L | 1 |
| Cross, N | 1 |
| Shi, X | 1 |
| Zhang, Y | 1 |
| Niu, H | 1 |
| Wang, R | 1 |
| Shen, J | 1 |
| Zhou, S | 1 |
| Yang, H | 1 |
| Wang, S | 1 |
| Van Dalen, YW | 1 |
| Blokhuis, C | 1 |
| Cohen, S | 1 |
| Ter Stege, JA | 1 |
| Teunissen, CE | 1 |
| Kuhle, J | 1 |
| Kootstra, NA | 1 |
| Scherpbier, HJ | 1 |
| Kuijpers, TW | 1 |
| Reiss, P | 1 |
| Majoie, CBLM | 1 |
| Caan, MWA | 1 |
| Pajkrt, D | 1 |
| García Santos, JM | 1 |
| Gavrila, D | 1 |
| Antúnez, C | 1 |
| Tormo, MJ | 1 |
| Salmerón, D | 1 |
| Carles, R | 1 |
| Jiménez Veiga, J | 1 |
| Parrilla, G | 1 |
| Torres del Río, S | 1 |
| Fortuna, L | 1 |
| Navarro, C | 1 |
| Paul, RH | 1 |
| Ernst, T | 1 |
| Brickman, AM | 1 |
| Yiannoutsos, CT | 1 |
| Tate, DF | 1 |
| Cohen, RA | 1 |
| Navia, BA | 1 |
| Ben Salem, D | 1 |
| Walker, PM | 1 |
| Bejot, Y | 1 |
| Aho, SL | 1 |
| Tavernier, B | 1 |
| Rouaud, O | 1 |
| Ricolfi, F | 1 |
| Brunotte, F | 1 |
| Kantarci, K | 5 |
| Petersen, RC | 5 |
| Przybelski, SA | 2 |
| Weigand, SD | 3 |
| Shiung, MM | 2 |
| Whitwell, JL | 2 |
| Negash, S | 2 |
| Ivnik, RJ | 4 |
| Boeve, BF | 5 |
| Knopman, DS | 4 |
| Smith, GE | 4 |
| Jack, CR | 5 |
| Erichsen, AK | 1 |
| Server, A | 1 |
| Landrø, NI | 1 |
| Sandvik, L | 1 |
| Tallaksen, CM | 1 |
| Wang, Z | 1 |
| Zhao, C | 1 |
| Yu, L | 1 |
| Zhou, W | 1 |
| Li, K | 1 |
| Kondziella, D | 1 |
| Danielsen, ER | 1 |
| Hansen, K | 1 |
| Thomsen, C | 1 |
| Jansen, EC | 1 |
| Arlien-Soeborg, P | 1 |
| Li, M | 2 |
| Sun, ZZ | 1 |
| Zhu, B | 1 |
| Yuan, L | 1 |
| Xu, Y | 1 |
| Yeo, R | 1 |
| Mannell, M | 1 |
| Ling, J | 1 |
| Elgie, R | 1 |
| Phillips, J | 1 |
| Doezema, D | 1 |
| Mayer, AR | 1 |
| Filley, CM | 1 |
| Kozora, E | 1 |
| Brown, MS | 1 |
| Miller, DE | 1 |
| West, SG | 1 |
| Arciniegas, DB | 1 |
| Grimm, A | 1 |
| Zhang, L | 1 |
| O'Brien, PC | 3 |
| Pilatus, U | 1 |
| Lais, C | 1 |
| Rochmont, Adu M | 1 |
| Kratzsch, T | 1 |
| Frölich, L | 1 |
| Maurer, K | 1 |
| Zanella, FE | 1 |
| Lanfermann, H | 2 |
| Pantel, J | 1 |
| Tiehuis, A | 1 |
| van der Meer, F | 1 |
| Mali, W | 1 |
| Pleizier, M | 1 |
| Biessels, GJ | 1 |
| Kappelle, J | 1 |
| Luijten, P | 1 |
| Govind, V | 1 |
| Gold, S | 1 |
| Kaliannan, K | 1 |
| Saigal, G | 1 |
| Falcone, S | 1 |
| Arheart, KL | 1 |
| Harris, L | 1 |
| Jagid, J | 1 |
| Maudsley, AA | 1 |
| Buschkuehl, M | 1 |
| Jaeggi, SM | 1 |
| Griffith, HR | 3 |
| Okonkwo, OC | 1 |
| den Hollander, JA | 2 |
| Belue, K | 1 |
| Copeland, J | 1 |
| Harrell, LE | 3 |
| Brockington, JC | 3 |
| Clark, DG | 1 |
| Marson, DC | 3 |
| Rao, V | 1 |
| Munro, CA | 1 |
| Rosenberg, P | 1 |
| Ward, J | 1 |
| Bertrand, M | 1 |
| Degoankar, M | 1 |
| Horská, A | 1 |
| Pham, D | 1 |
| Yousem, DM | 1 |
| Barker, PB | 1 |
| Li, X | 2 |
| Shao, X | 1 |
| Wang, N | 1 |
| Wang, T | 1 |
| Chen, G | 1 |
| Zhou, H | 1 |
| Premkumar, P | 1 |
| Parbhakar, VA | 1 |
| Fannon, D | 1 |
| Lythgoe, D | 1 |
| Williams, SC | 1 |
| Kuipers, E | 1 |
| Kumari, V | 1 |
| Bokemeyer, M | 1 |
| Ding, XQ | 1 |
| Goldbecker, A | 1 |
| Raab, P | 1 |
| Heeren, M | 1 |
| Arvanitis, D | 1 |
| Tillmann, HL | 1 |
| Weissenborn, K | 1 |
| Valayannopoulos, V | 1 |
| Boddaert, N | 1 |
| Chabli, A | 1 |
| Barbier, V | 1 |
| Desguerre, I | 1 |
| Philippe, A | 1 |
| Afenjar, A | 1 |
| Mazzuca, M | 1 |
| Cheillan, D | 1 |
| Munnich, A | 1 |
| de Keyzer, Y | 1 |
| Jakobs, C | 1 |
| Salomons, GS | 1 |
| de Lonlay, P | 1 |
| Pattullo, V | 1 |
| McAndrews, MP | 1 |
| Damyanovich, A | 1 |
| Heathcote, EJ | 1 |
| Seese, RR | 1 |
| O'Neill, J | 1 |
| Hudkins, M | 1 |
| Siddarth, P | 1 |
| Levitt, J | 1 |
| Tseng, B | 1 |
| Wu, KN | 1 |
| Caplan, R | 1 |
| Liu, ZY | 1 |
| Guo, H | 1 |
| Zhang, XL | 1 |
| Liu, J | 1 |
| Qu, HY | 1 |
| Peng, W | 1 |
| Bao, YM | 1 |
| Yin, LL | 1 |
| Song, YX | 1 |
| Byrnes, V | 1 |
| Miller, A | 1 |
| Lowry, D | 1 |
| Hill, E | 1 |
| Weinstein, C | 1 |
| Alsop, D | 1 |
| Lenkinski, R | 1 |
| Afdhal, NH | 1 |
| Blinkenberg, M | 1 |
| Mathiesen, HK | 1 |
| Tscherning, T | 1 |
| Jønsson, A | 1 |
| Svarer, C | 1 |
| Holm, S | 1 |
| Sellebjerg, F | 1 |
| Paulson, OB | 1 |
| Hanson, LG | 1 |
| Sorensen, PS | 1 |
| Owen, L | 1 |
| Sunram-Lea, SI | 1 |
| Lim, TS | 1 |
| Hong, YH | 1 |
| Lee, HY | 1 |
| Choi, JY | 1 |
| Kim, HS | 1 |
| Moon, SY | 1 |
| Gonzales, MM | 1 |
| Tarumi, T | 1 |
| Eagan, DE | 1 |
| Tanaka, H | 1 |
| Vaghasia, M | 1 |
| Haley, AP | 1 |
| Shine, JM | 1 |
| Duffy, S | 1 |
| Halliday, G | 1 |
| Bai, Z | 1 |
| Liu, F | 1 |
| Song, G | 1 |
| Xu, J | 1 |
| Chanson, JB | 1 |
| Echaniz-Laguna, A | 1 |
| Blanc, F | 1 |
| Lacour, A | 1 |
| Ballonzoli, L | 1 |
| Kremer, S | 1 |
| Namer, IJ | 1 |
| Lannes, B | 1 |
| Tranchant, C | 1 |
| Vermersch, P | 1 |
| de Seze, J | 1 |
| Bakker, FC | 1 |
| Klijn, CJ | 1 |
| Jennekens-Schinkel, A | 1 |
| van der Tweel, I | 1 |
| van der Grond, J | 2 |
| van Huffelen, AC | 1 |
| Tulleken, CA | 1 |
| Kappelle, LJ | 2 |
| Weiss, U | 1 |
| Bacher, R | 1 |
| Vonbank, H | 1 |
| Kemmler, G | 1 |
| Lingg, A | 1 |
| Marksteiner, J | 1 |
| Reynolds, G | 1 |
| Edland, SD | 1 |
| Tangalos, EG | 3 |
| Christodoulou, C | 1 |
| Krupp, LB | 1 |
| Liang, Z | 1 |
| Huang, W | 1 |
| Melville, P | 1 |
| Roque, C | 1 |
| Scherl, WF | 1 |
| Morgan, T | 1 |
| MacAllister, WS | 1 |
| Li, L | 1 |
| Tudorica, LA | 1 |
| Roche, P | 1 |
| Peyster, R | 1 |
| Obergriesser, T | 1 |
| Ende, G | 1 |
| Braus, DF | 1 |
| Henn, FA | 1 |
| Sparkes, SJ | 1 |
| MacMaster, FP | 1 |
| Carrey, NC | 1 |
| Weisskopf, MG | 1 |
| Hu, H | 1 |
| Mulkern, RV | 1 |
| White, R | 1 |
| Aro, A | 1 |
| Oliveira, S | 1 |
| Wright, RO | 1 |
| Assini, A | 1 |
| Cammarata, S | 1 |
| Vitali, A | 1 |
| Colucci, M | 1 |
| Giliberto, L | 1 |
| Borghi, R | 1 |
| Inglese, ML | 1 |
| Volpe, S | 1 |
| Ratto, S | 1 |
| Dagna-Bricarelli, F | 1 |
| Baldo, C | 1 |
| Argusti, A | 1 |
| Odetti, P | 1 |
| Piccini, A | 1 |
| Tabaton, M | 1 |
| Frederick, BD | 1 |
| Lyoo, IK | 1 |
| Satlin, A | 1 |
| Ahn, KH | 1 |
| Kim, MJ | 1 |
| Yurgelun-Todd, DA | 1 |
| Cohen, BM | 1 |
| Renshaw, PF | 1 |
| Parry, L | 1 |
| Shores, A | 1 |
| Rae, C | 1 |
| Kemp, A | 1 |
| Waugh, MC | 1 |
| Chaseling, R | 1 |
| Joy, P | 1 |
| Wang, LN | 1 |
| Wang, W | 1 |
| Zhang, XH | 1 |
| Ma, L | 1 |
| Yin, H | 1 |
| Li, DJ | 1 |
| van Zandvoort, MJ | 1 |
| de Haan, EH | 1 |
| Pina, MA | 1 |
| Nelson, JA | 1 |
| Dou, H | 1 |
| Ellison, B | 1 |
| Uberti, M | 1 |
| Xiong, H | 1 |
| Anderson, E | 1 |
| Mellon, M | 1 |
| Gelbard, HA | 1 |
| Boska, M | 1 |
| Gendelman, HE | 1 |
| Meng, XM | 1 |
| Zhu, DM | 1 |
| Ruan, DY | 1 |
| She, JQ | 1 |
| Luo, L | 1 |
| Metastasio, A | 1 |
| Rinaldi, P | 1 |
| Tarducci, R | 2 |
| Mariani, E | 1 |
| Feliziani, FT | 1 |
| Cherubini, A | 2 |
| Pelliccioli, GP | 2 |
| Gobbi, G | 2 |
| Senin, U | 2 |
| Mecocci, P | 2 |
| Azevedo, D | 2 |
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| Coplan, JD | 1 |
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| Mao, X | 1 |
| Smith, EL | 1 |
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| Evanochko, WT | 2 |
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| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Carotid Plaque Imaging in Acute Stroke[NCT01284933] | 234 participants (Actual) | Observational | 2011-02-28 | Completed | |||
| MRI Biomarkers of Risk in Sedentary and Exercise Trained Humans[NCT02729428] | 71 participants (Actual) | Observational | 2016-04-30 | Completed | |||
| Personalized Medicine in HCV Infection: Cognitive Impairments and Brain Anomalies in Chronic Hepatitis C Infected Individuals. Characterization and Potential Reversibility With Direct Antiviral Agents.[NCT02745132] | Phase 4 | 80 participants (Anticipated) | Interventional | 2016-06-30 | Not yet recruiting | ||
| A Study of the Cerebral Effect of Pegylated Interferon in Hepatitis C Positive Subjects[NCT00136214] | 22 participants (Actual) | Observational | 2004-03-31 | Completed | |||
| The Effects of PeakATP (Adenosine 5' - Triphosphate Disodium) Supplementation vs. Placebo on Measures of Mood, Reaction Time and Cognitive Performance[NCT05100589] | 35 participants (Actual) | Interventional | 2021-10-06 | Completed | |||
| In Vivo Investigation on Mitochondrial Dysfunction in Post-COVID Fatigue and Cancer Fatigue.[NCT05753228] | 90 participants (Anticipated) | Interventional | 2022-12-09 | Recruiting | |||
| An Open-label Exploratory Study With Memantine: Correlation Between Proton Magnetic Resonance Spectroscopy, Cerebrospinal Fluid Biomarkers, and Cognition in Patients With Mild to Moderate Alzheimer's Disease[NCT00551161] | Phase 4 | 12 participants (Actual) | Interventional | 2007-08-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
A battery of pen and paper neurocognitive tests where subject means are reported compared to the normative Z score. Data is reported at baseline (T1), week 12 on treatment (T2) and 12 weeks after treatment (week 60, T3). Improvements are increases in the test result compared to baseline as determined against the Z score. tests performed included Hopkins learning trials (HVLT), a measure of of verbal learning and memory and the Roy-Osterrieth Complex figure test (ROCF) which evaluates visio-spatal abilities, memory, planning and working memory. Improvements in the score (increases in value compared, either less negative or more positive to the Z score) shown in the table are reflective of improvements in these neurocognitive parameters. (NCT00136214)
Timeframe: 18 months overall with measures performed at baseline (T1), week 12 (T2) and 12 weeks after end of treatment (T3) with PEG-IFN for 48 weeks which is 60 weeks post baseline and only done in treated group and not controls
| Intervention | Z-score (Mean) | |||||
|---|---|---|---|---|---|---|
| HVLT, Verbal Learning Total, T1 | HVLT, Verbal Learning Total, T2 | HVLT, Verbal Learning Total, T3 | ROCF, T1 | ROCF, T2 | ROCF,T3 | |
| Interferon Treated Group | -1.43 | -0.78 | -0.7 | 0.34 | 0.15 | 0.33 |
| Non-treated Cohort Control | -2.0 | -1.16 | NA | -1.0 | 0.05 | NA |
Evaluation of changes in MR spectroscopy. reductions in ratio of Cho and MI reflect improvements in cerebral inflammation and improvement in cognition. Increases in the NAA ratio are suggestive of improvement in cognitive function. (NCT00136214)
Timeframe: 18 months overall with measures performed at baseline (T1), week 12 (T2) and 12 weeks after end of treatment (T3) with PEG-IFN for 48 weeks which is 60 weeks post baseline
| Intervention | ratio (Mean) | ||||||||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Basal Ganglia, T1, Cho/Cr | Basal Ganglia,T2, Cho/Cr | Basal Ganglia, T3, Cho/Cr | Basal Ganglia, T1, MI/Cr | Basal Ganglia T2. MI/C | Basal Ganglia T3, MI/C | Frontal Cortex T1, Cho/Cr | Frontal Cortex T2, Cho/Cr | Frontal Cortex T3, Cho/Cr | Basal Ganglia T1, NAA/Cr | Basal Ganglia T2, NAA/Cr | Basal Ganglia T3, NAA/Cr | Frontal Cortex T1,Mi/Cr | Frontal Cortex T2, MI/Cr | Frontal Cortex T3, MI/Cr | Frontal Cortex T1, NAA/Cr | Frontal Cortex T2, NAA/Cr | Frontal Cortex T3, NAA/Cr | DLPFC T1, Cho/Cr | DLPFC T2, Cho/Cr | DLPFC T3, Cho/Cr | DLPFC T1, MI/Cr | DLPFC T2, MI/Cr | DLPFC T3/ MI/Cr | DLPFC T1, NAA/Cr | DLPFC T2, NAA/Cr | DLFPC T3, NAA/Cr | |
| Interferon Treated Group | 0.42 | 0.28 | 0.34 | 0.78 | 0.71 | 0.75 | 0.29 | 0.26 | 0.29 | 1.26 | 1.25 | 1.09 | 0.68 | 0.75 | 0.71 | 1.73 | 1.74 | 1.75 | 0.31 | 0.25 | 0.26 | 0.79 | 0.75 | 0.93 | 1.72 | 1.65 | 1.78 |
| Non-treated Cohort Control | 0.30 | 0.28 | NA | 0.78 | 0.72 | NA | 0.28 | 0.29 | NA | 1.28 | 1.07 | NA | 0.77 | 1.19 | NA | 1.55 | 1.72 | NA | 0.27 | 0.27 | NA | 0.78 | 0.86 | NA | 1.61 | 1.60 | NA |
Ratios of myo-inositol (mI), N-acetylaspartate (NAA), total creatine (Cr), and choline (Cho) by single voxel 1H MRS (proton magnetic resonance spectroscopy). Mean (± SD) metabolite levels (normalized to T2-corrected water signal intensity) and metabolite ratios for Alzheimer's disease subjects at baseline (t0), after 24 weeks of ongoing monotherapy with stable-dose cholinesterase inhibitor (t1), and after another 24 weeks of combination therapy with memantine in addition to stable-dose cholinesterase inhibitor (t2). The Wilcoxon signed-rank test was used to examine whether the change between t0 and t1 differed from the change between t1 and t2 [(t2 - t1) - (t1 - t0)]. (NCT00551161)
Timeframe: Baseline, 24 weeks, and 48 weeks
| Intervention | ratio (normalized to T2-corrected water (Mean) | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| Change in NAA [(t2-t1) - (t1-t0)] | Change in Cr [(t2-t1) - (t1-t0)] | Change in Cho [(t2-t1) - (t1-t0)] | Change in mI [(t2-t1) - (t1-t0)] | Change in NAA/Cr [(t2-t1) - (t1-t0)] | Change in Cho/Cr [(t2-t1) - (t1-t0)] | Change in mI/Cr [(t2-t1) - (t1-t0)] | Change in NAA/Cho [(t2-t1) - (t1-t0)] | Change in NAA/mI [(t2-t1) - (t1-t0)] | |
| Memantine | -54 | -2 | 9 | 16 | -0.09 | 0.02 | 0.04 | -0.26 | -0.35 |
2 reviews available for creatine and Cognition Disorders
| Article | Year |
|---|---|
Improving intelligence: a literature review.
Topics: Achievement; Adolescent; Adult; Aged; Attention Deficit Disorder with Hyperactivity; Central Nervous | 2010 |
Metabolic agents that enhance ATP can improve cognitive functioning: a review of the evidence for glucose, oxygen, pyruvate, creatine, and L-carnitine.
Topics: Adenosine Triphosphate; Aging; Brain; Carnitine; Cognition; Cognition Disorders; Creatine; Energy Me | 2011 |
10 trials available for creatine and Cognition Disorders
| Article | Year |
|---|---|
The Effect of a High-Dose Vitamin B Multivitamin Supplement on the Relationship between Brain Metabolism and Blood Biomarkers of Oxidative Stress: A Randomized Control Trial.
Topics: Adult; Aged; Antioxidants; Aspartic Acid; Biomarkers; Brain; Cognition; Cognition Disorders; Creatin | 2018 |
PRECREST: a phase II prevention and biomarker trial of creatine in at-risk Huntington disease.
Topics: Adult; Atrophy; Biomarkers; Brain; Cognition Disorders; Creatine; Cross-Over Studies; Diffusion Magn | 2014 |
Creatine supplementation enhances corticomotor excitability and cognitive performance during oxygen deprivation.
Topics: Adult; Aspartic Acid; Blood Pressure; Cognition Disorders; Creatine; Dietary Supplements; Evoked Pot | 2015 |
The effect of 12-wk ω-3 fatty acid supplementation on in vivo thalamus glutathione concentration in patients "at risk" for major depression.
Topics: Aged; Aged, 80 and over; Cognition Disorders; Creatine; Depressive Disorder, Major; Dietary Suppleme | 2015 |
Magnetic resonance spectroscopy performance for detection of dementia, Alzheimer's disease and mild cognitive impairment in a community-based survey.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Aspartic Acid; Brain; Choline; Cognition Disorders; Crea | 2008 |
Effects of anti-viral therapy and HCV clearance on cerebral metabolism and cognition.
Topics: Adult; Aged; Antiviral Agents; Aspartic Acid; Basal Ganglia; Choline; Cognition; Cognition Disorders | 2012 |
Effects of anti-viral therapy and HCV clearance on cerebral metabolism and cognition.
Topics: Adult; Aged; Antiviral Agents; Aspartic Acid; Basal Ganglia; Choline; Cognition; Cognition Disorders | 2012 |
Effects of anti-viral therapy and HCV clearance on cerebral metabolism and cognition.
Topics: Adult; Aged; Antiviral Agents; Aspartic Acid; Basal Ganglia; Choline; Cognition; Cognition Disorders | 2012 |
Effects of anti-viral therapy and HCV clearance on cerebral metabolism and cognition.
Topics: Adult; Aged; Antiviral Agents; Aspartic Acid; Basal Ganglia; Choline; Cognition; Cognition Disorders | 2012 |
Cognitive impairment is related to cerebral lactate in patients with carotid artery occlusion and ipsilateral transient ischemic attacks.
Topics: Adult; Aged; Aspartic Acid; Blood Flow Velocity; Brain; Carbon Dioxide; Carotid Artery Diseases; Cer | 2003 |
Cognitive performance and MR markers of cerebral injury in cognitively impaired MS patients.
Topics: Adult; Aspartic Acid; Atrophy; Axons; Biomarkers; Cerebral Cortex; Choline; Cognition Disorders; Cre | 2003 |
Creatine supplementation and cognitive performance in elderly individuals.
Topics: Aged; Aged, 80 and over; Analysis of Variance; Cognition; Cognition Disorders; Creatine; Cross-Over | 2007 |
Proton spectroscopy in Alzheimer's disease and cognitive impairment no dementia: a community-based study.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Aspartic Acid; Atrophy; Brain; Choline; Cognition Disord | 2008 |
88 other studies available for creatine and Cognition Disorders
| Article | Year |
|---|---|
Cyclocreatine treatment ameliorates the cognitive, autistic and epileptic phenotype in a mouse model of Creatine Transporter Deficiency.
Topics: Animals; Autistic Disorder; Blood-Brain Barrier; Brain Diseases, Metabolic, Inborn; Cerebrovascular | 2020 |
Study on the clinical application of the MRS in the cognitive assessment after stroke.
Topics: Aspartic Acid; Cognition; Cognition Disorders; Cognitive Dysfunction; Creatine; Hippocampus; Humans; | 2017 |
NSCs promote hippocampal neurogenesis, metabolic changes and synaptogenesis in APP/PS1 transgenic mice.
Topics: Alzheimer Disease; Animals; Aspartic Acid; Cognition Disorders; Creatine; Disease Models, Animal; Gl | 2017 |
Reduced occipital GABA in Parkinson disease with visual hallucinations.
Topics: Aged; Aged, 80 and over; Cognition Disorders; Creatine; Female; gamma-Aminobutyric Acid; Gray Matter | 2018 |
1H-MR spectroscopy metabolite levels correlate with executive function in vascular cognitive impairment.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Aspartic Acid; Biomarkers; Brain Ischemia; Choline; Cogn | 2013 |
Female mice heterozygous for creatine transporter deficiency show moderate cognitive deficits.
Topics: Animals; Behavior, Animal; Brain; Brain Diseases, Metabolic, Inborn; Cognition Disorders; Creatine; | 2014 |
The carotid plaque imaging in acute stroke (CAPIAS) study: protocol and initial baseline data.
Topics: Aged; Carotid Stenosis; Cerebral Cortex; Cognition Disorders; Cohort Studies; Creatine; Disease Prog | 2013 |
Clinical correlations of proton magnetic resonance spectroscopy findings in acute phase after mild traumatic brain injury.
Topics: Adult; Aspartic Acid; Biomarkers; Brain Injuries; Cognition Disorders; Creatine; Female; Frontal Lob | 2014 |
Feasibility of Huntington disease trials in the disease prodrome.
Topics: Brain; Cognition Disorders; Creatine; Humans; Huntington Disease | 2014 |
Decreased cerebrospinal fluid levels of L-carnitine in non-apolipoprotein E4 carriers at early stages of Alzheimer's disease.
Topics: Aged; Alzheimer Disease; Amyloid beta-Peptides; Apolipoprotein E4; Arginine; Biomarkers; Carnitine; | 2014 |
The effects of unilateral 6-OHDA lesion in medial forebrain bundle on the motor, cognitive dysfunctions and vulnerability of different striatal interneuron types in rats.
Topics: Adrenergic Agents; Animals; Apomorphine; Choline O-Acetyltransferase; Cognition Disorders; Corpus St | 2014 |
Recombinant human growth hormone improves cognitive capacity in a pain patient exposed to chronic opioids.
Topics: Apoptosis; Arginine; Aspartic Acid; Cognition Disorders; Creatine; Growth Hormone; Growth Hormone-Re | 2014 |
Thalamic metabolic alterations with cognitive dysfunction in idiopathic trigeminal neuralgia: a multivoxel spectroscopy study.
Topics: Adult; Aged; Aspartic Acid; Case-Control Studies; Choline; Cognition Disorders; Creatine; Female; Hu | 2014 |
Immunotherapy-responsive limbic encephalitis with antibodies to glutamic acid decarboxylase.
Topics: Antibodies; Aspartic Acid; Choline; Cognition Disorders; Creatine; Female; Glutamate Decarboxylase; | 2014 |
Higher glutamate+glutamine and reduction of N-acetylaspartate in posterior cingulate according to age range in patients with cognitive impairment and/or pain.
Topics: Adult; Age Factors; Aged; Aged, 80 and over; Aspartic Acid; Case-Control Studies; Cognition Disorder | 2014 |
Reduced N-acetylaspartate to creatine ratio in the posterior cingulate correlates with cognition in Alzheimer's disease following four months of rivastigmine treatment.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Aspartic Acid; Cholinesterase Inhibitors; Cognition Diso | 2015 |
Germinoma in the bilateral basal ganglia presented with cognitive deterioration.
Topics: Adolescent; Aspartic Acid; Basal Ganglia; Brain Neoplasms; Cognition Disorders; Creatine; Germinoma; | 2015 |
A Prophylactic Role for Creatine in Hypoxia?
Topics: Cognition Disorders; Creatine; Dietary Supplements; Female; Humans; Hypoxia; Male; Motor Cortex; Neu | 2015 |
[1H-proton magnetic resonance spectroscopy in patients with multiple system atrophy and
cognitive dysfunction].
Topics: Aspartic Acid; Choline; Cognition Disorders; Creatine; Frontal Lobe; Humans; Inositol; Multiple Syst | 2015 |
Neurometabolic characteristics in the anterior cingulate gyrus of Alzheimer's disease patients with depression: a (1)H magnetic resonance spectroscopy study.
Topics: Aged; Alzheimer Disease; Aspartic Acid; Cognition Disorders; Creatine; Depressive Disorder; Female; | 2015 |
Association of Anterior Cingulate Glutathione with Sleep Apnea in Older Adults At-Risk for Dementia.
Topics: Aged; Aging; Biomarkers; Cognition Disorders; Cognitive Dysfunction; Creatine; Dementia; Depression; | 2016 |
[Correlation between cognitive impairment and diabetic nephropathy in patients with Type 2 diabetes mellitus].
Topics: Adult; Aspartic Acid; Case-Control Studies; Cerebrum; Choline; Cognition; Cognition Disorders; Creat | 2016 |
Neurometabolite Alterations Associated With Cognitive Performance in Perinatally HIV-Infected Children.
Topics: Adolescent; AIDS Dementia Complex; Aspartic Acid; Brain; CD4 Lymphocyte Count; Child; Choline; Cogni | 2016 |
Relative sensitivity of magnetic resonance spectroscopy and quantitative magnetic resonance imaging to cognitive function among nondemented individuals infected with HIV.
Topics: Adult; Affect; Aspartic Acid; Choline; Cognition Disorders; Creatine; Female; HIV Infections; Humans | 2008 |
N-acetylaspartate/creatine and choline/creatine ratios in the thalami, insular cortex and white matter as markers of hypertension and cognitive impairment in the elderly.
Topics: Aged; Aged, 80 and over; Aging; Aspartic Acid; Biomarkers; Cerebral Cortex; Choline; Cognition Disor | 2008 |
Hippocampal volumes, proton magnetic resonance spectroscopy metabolites, and cerebrovascular disease in mild cognitive impairment subtypes.
Topics: Aged; Aged, 80 and over; Aspartic Acid; Case-Control Studies; Cerebrovascular Disorders; Chi-Square | 2008 |
Proton magnetic resonance spectroscopy and cognition in patients with spastin mutations.
Topics: Adenosine Triphosphatases; Adult; Aspartic Acid; Biomarkers; Choline; Cognition Disorders; Creatine; | 2009 |
Regional metabolic changes in the hippocampus and posterior cingulate area detected with 3-Tesla magnetic resonance spectroscopy in patients with mild cognitive impairment and Alzheimer disease.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Aspartic Acid; Cognition Disorders; Creatine; Dominance, | 2009 |
1H MR spectroscopy of gray and white matter in carbon monoxide poisoning.
Topics: Adolescent; Adult; Aspartic Acid; Brain; Carbon Monoxide Poisoning; Choline; Cognition Disorders; Cr | 2009 |
Evaluation of functional MRI markers in mild cognitive impairment.
Topics: Aged; Aged, 80 and over; Analysis of Variance; Aspartic Acid; Brain; Brain Mapping; Cognition Disord | 2009 |
Neurometabolite concentrations in gray and white matter in mild traumatic brain injury: an 1H-magnetic resonance spectroscopy study.
Topics: Adult; Affective Symptoms; Axons; Biomarkers; Body Water; Brain; Brain Injuries; Cognition Disorders | 2009 |
White matter microstructure and cognition in non-neuropsychiatric systemic lupus erythematosus.
Topics: Adult; Aspartic Acid; Axons; Brain; Brain Chemistry; Choline; Cognition; Cognition Disorders; Creati | 2009 |
Risk of dementia in MCI: combined effect of cerebrovascular disease, volumetric MRI, and 1H MRS.
Topics: Aged; Aged, 80 and over; Aspartic Acid; Atrophy; Biomarkers; Brain; Cerebrovascular Disorders; Cogni | 2009 |
Conversion to dementia in mild cognitive impairment is associated with decline of N-actylaspartate and creatine as revealed by magnetic resonance spectroscopy.
Topics: Aged; Alzheimer Disease; Aspartic Acid; Brain; Choline; Cognition; Cognition Disorders; Creatine; De | 2009 |
MR spectroscopy of cerebral white matter in type 2 diabetes; no association with clinical variables and cognitive performance.
Topics: Aged; Aged, 80 and over; Aspartic Acid; Brain; Choline; Cognition; Cognition Disorders; Creatine; Di | 2010 |
Whole-brain proton MR spectroscopic imaging of mild-to-moderate traumatic brain injury and correlation with neuropsychological deficits.
Topics: Adolescent; Adult; Aspartic Acid; Biomarkers; Brain; Brain Injuries; Choline; Cognition Disorders; C | 2010 |
Brain metabolic correlates of decision making in amnestic mild cognitive impairment.
Topics: Aged; Amnesia; Aspartic Acid; Brain; Choline; Cognition Disorders; Creatine; Decision Making; Female | 2010 |
Neuroanatomical correlates of depression in post traumatic brain injury: preliminary results of a pilot study.
Topics: Adult; Aspartic Acid; Basal Ganglia; Brain; Brain Injuries; Case-Control Studies; Choline; Cognition | 2010 |
Correlation of auditory event-related potentials and magnetic resonance spectroscopy measures in mild cognitive impairment.
Topics: Acoustic Stimulation; Aged; Aspartic Acid; Brain Chemistry; Cognition Disorders; Creatine; Electroen | 2010 |
N-acetyl aspartate concentration in the anterior cingulate cortex in patients with schizophrenia: a study of clinical and neuropsychological correlates and preliminary exploration of cognitive behaviour therapy effects.
Topics: Adolescent; Adult; Analysis of Variance; Aspartic Acid; Child; Choline; Cognition Disorders; Cogniti | 2010 |
Evidence for neuroinflammation and neuroprotection in HCV infection-associated encephalopathy.
Topics: Adult; Aged; Aspartic Acid; Brain; Brain Mapping; Case-Control Studies; Choline; Cognition Disorders | 2011 |
Treatment by oral creatine, L-arginine and L-glycine in six severely affected patients with creatine transporter defect.
Topics: Administration, Oral; Adolescent; Amino Acid Transport Disorders, Inborn; Arginine; Child; Child, Pr | 2012 |
Influence of hepatitis C virus on neurocognitive function in patients free from other risk factors: validation from therapeutic outcomes.
Topics: Aspartic Acid; Brain; Cognition Disorders; Cohort Studies; Creatine; Fatigue; Female; Globus Pallidu | 2011 |
Proton magnetic resonance spectroscopy and thought disorder in childhood schizophrenia.
Topics: Adolescent; Analysis of Variance; Aspartic Acid; Brain; Child; Choline; Cognition Disorders; Creatin | 2011 |
[Impacts of electroacupuncture on left hippocampus NAA/Cr for patients of Uygur and Han nationality with mild cognitive impairment].
Topics: Aged; Aged, 80 and over; Aspartic Acid; China; Cognition Disorders; Creatine; Electroacupuncture; Fe | 2011 |
Cerebral metabolism, magnetic resonance spectroscopy and cognitive dysfunction in early multiple sclerosis: an exploratory study.
Topics: Adult; Aspartic Acid; Brain; Cerebral Cortex; Cognition Disorders; Creatine; Female; Glucose; Humans | 2012 |
Metabolite investigation in both anterior and posterior cingulate gyri in Alzheimer's disease spectrum using 3-tesla MR spectroscopy.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Aspartic Acid; Cognition Disorders; Creatine; Disease Pr | 2012 |
Indirect effects of elevated body mass index on memory performance through altered cerebral metabolite concentrations.
Topics: Adult; Aspartic Acid; Biomarkers; Body Mass Index; Brain; Choline; Cognition Disorders; Creatine; Fe | 2012 |
Anterior cingulate integrity: executive and neuropsychiatric features in Parkinson's disease.
Topics: Aged; Aspartic Acid; Case-Control Studies; Cognition Disorders; Creatine; Female; Gyrus Cinguli; Hum | 2012 |
Reduced posterior cingulate glutamate measured by magnetic resonance spectroscopy in hyperthyroidism.
Topics: Adult; Aspartic Acid; Choline; Cognition Disorders; Creatine; Female; Glutamic Acid; Gyrus Cinguli; | 2012 |
Central nervous system abnormalities in patients with PMP22 gene mutations: a prospective study.
Topics: Aged; Aspartic Acid; Brain; Brain Chemistry; Central Nervous System; Cognition Disorders; Cohort Stu | 2013 |
Cognitive impairment: assessment with brain magnetic resonance imaging and proton magnetic resonance spectroscopy.
Topics: Aged; Alzheimer Disease; Aspartic Acid; Brain; Brain Chemistry; Choline; Cognition Disorders; Creati | 2003 |
Proton MR spectroscopy in mild cognitive impairment and Alzheimer disease: comparison of 1.5 and 3 T.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Aspartic Acid; Brain; Choline; Cognition Disorders; Crea | 2003 |
Long-term follow-up of magnetic resonance-detectable choline signal changes in the hippocampus of patients treated with electroconvulsive therapy.
Topics: Aspartic Acid; Choline; Cognition Disorders; Creatine; Depressive Disorder, Major; Electroconvulsive | 2003 |
Proton magnetic resonance spectroscopy and cognitive function in pediatric attention-deficit/hyperactive disorder.
Topics: Aspartic Acid; Attention Deficit Disorder with Hyperactivity; Brain Stem; Child; Choline; Cognition | 2004 |
Cognitive deficits and magnetic resonance spectroscopy in adult monozygotic twins with lead poisoning.
Topics: Aged; Aspartic Acid; Bone and Bones; Brain; Cell Count; Cognition Disorders; Creatine; Diseases in T | 2004 |
Plasma levels of amyloid beta-protein 42 are increased in women with mild cognitive impairment.
Topics: Age of Onset; Aged; Alzheimer Disease; Amyloid beta-Peptides; Apolipoproteins E; Biomarkers; Cholest | 2004 |
In vivo proton magnetic resonance spectroscopy of the temporal lobe in Alzheimer's disease.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Analysis of Variance; Aspartic Acid; Brain Mapping; Case | 2004 |
An investigation of neuronal integrity in severe paediatric traumatic brain injury.
Topics: Adolescent; Age Factors; Aspartic Acid; Brain Injuries; Child; Choline; Cognition Disorders; Creatin | 2004 |
[An interventional study on amnestic mild cognitive impairment with small dose donepezil].
Topics: Aged; Aged, 80 and over; Amnesia; Aspartic Acid; Cognition; Cognition Disorders; Creatine; Donepezil | 2004 |
Cognitive deficits and changes in neurometabolites after a lacunar infarct.
Topics: Aged; Analysis of Variance; Aspartic Acid; Brain Infarction; Case-Control Studies; Choline; Cognitio | 2005 |
Conversion from mild cognitive impairment to probable Alzheimer's disease predicted by brain magnetic resonance spectroscopy.
Topics: Aged; Alzheimer Disease; Aspartic Acid; Brain; Choline; Cognition Disorders; Cohort Studies; Creatin | 2005 |
Coregistration of quantitative proton magnetic resonance spectroscopic imaging with neuropathological and neurophysiological analyses defines the extent of neuronal impairments in murine human immunodeficiency virus type-1 encephalitis.
Topics: AIDS Dementia Complex; Animals; Aspartic Acid; Brain Mapping; Calcium-Binding Proteins; Capsid Prote | 2005 |
Effects of chronic lead exposure on 1H MRS of hippocampus and frontal lobes in children.
Topics: Aspartic Acid; Cell Membrane; Cell Survival; Child; Choline; Chronic Disease; Cognition Disorders; C | 2005 |
Conversion of MCI to dementia: Role of proton magnetic resonance spectroscopy.
Topics: Aged; Amnesia; Aspartic Acid; Cerebral Cortex; Choline; Cognition Disorders; Creatine; Dementia; Dis | 2006 |
[Proton spectroscopy in Alzheimer's disease and cognitive impairment not dementia: a community study].
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Aspartic Acid; Case-Control Studies; Choline; Cognition | 2005 |
Decreased choline and creatine concentrations in centrum semiovale in patients with generalized anxiety disorder: relationship to IQ and early trauma.
Topics: Adult; Anxiety Disorders; Body Mass Index; Choline; Cognition Disorders; Creatine; Frontal Lobe; Fun | 2006 |
Longitudinal 1H MRS changes in mild cognitive impairment and Alzheimer's disease.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Analysis of Variance; Aspartic Acid; Choline; Cognition | 2007 |
Cognitive impairment and in vivo metabolites in first-episode neuroleptic-naive and chronic medicated schizophrenic patients: a proton magnetic resonance spectroscopy study.
Topics: Adult; Aged; Antipsychotic Agents; Aspartic Acid; Choline; Chronic Disease; Cognition Disorders; Cre | 2007 |
Prediction of cognitive decline after stroke using proton magnetic resonance spectroscopy.
Topics: Aged; Aged, 80 and over; Analysis of Variance; Aspartic Acid; Brain Chemistry; Cognition Disorders; | 2006 |
Elevated brain scyllo-inositol concentrations in patients with Alzheimer's disease.
Topics: Aged; Alzheimer Disease; Aspartic Acid; Biopsy; Brain; Cognition Disorders; Creatine; Female; Humans | 2007 |
A decrease in N-acetylaspartate and an increase in myoinositol in the anterior cingulate gyrus are associated with behavioral and psychological symptoms in Alzheimer's disease.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Aspartic Acid; Brain Chemistry; Cognition Disorders; Cre | 2007 |
Executive function is associated with brain proton magnetic resonance spectroscopy in amnestic mild cognitive impairment.
Topics: Aged; Amnesia; Analysis of Variance; Cognition Disorders; Creatine; Female; Gyrus Cinguli; Humans; I | 2007 |
Cortical brain metabolism as measured by proton spectroscopy is related to memory performance in patients with amnestic mild cognitive impairment and Alzheimer's disease.
Topics: Aged; Alzheimer Disease; Amnesia; Aspartic Acid; Cerebral Cortex; Cognition Disorders; Creatine; Fem | 2007 |
Naming is associated with left temporal pole metabolite levels in neurodegenerative diseases.
Topics: Aged; Amnesia; Anomia; Aspartic Acid; Choline; Cognition Disorders; Creatine; Dementia; Female; Huma | 2008 |
Elevated 3T proton MRS glutamate levels associated with poor Continuous Performance Test (CPT-0X) scores and genetic risk for schizophrenia.
Topics: Adult; Attention; Cognition Disorders; Creatine; Discrimination, Psychological; Female; Frontal Lobe | 2008 |
1H-magnetic resonance spectroscopy of the left temporal and frontal lobes in schizophrenia: clinical, neurodevelopmental, and cognitive correlates.
Topics: Adult; Choline; Cognition Disorders; Creatine; Female; Frontal Lobe; Humans; Magnetic Resonance Spec | 1994 |
Reduced brain N-acetylaspartate suggests neuronal loss in cognitively impaired human immunodeficiency virus-seropositive individuals: in vivo 1H magnetic resonance spectroscopic imaging.
Topics: Adult; Aspartic Acid; Brain; Choline; Cognition Disorders; Creatine; HIV Seropositivity; Humans; Mag | 1993 |
Proton magnetic resonance spectroscopy for detection of axonal injury in the splenium of the corpus callosum of brain-injured patients.
Topics: Acceleration; Accidents, Traffic; Adult; Aged; Aspartic Acid; Axons; Brain Concussion; Brain Disease | 1998 |
Relationship between neurometabolite derangement and neurocognitive dysfunction in systemic lupus erythematosus.
Topics: Adult; Aspartic Acid; Brain; Choline; Cognition Disorders; Creatine; Female; Humans; Lupus Erythemat | 1999 |
Correlates of executive function in multiple sclerosis: the use of magnetic resonance spectroscopy as an index of focal pathology.
Topics: Adult; Analysis of Variance; Aspartic Acid; Attention; Biomarkers; Case-Control Studies; Chi-Square | 1999 |
Cognitive correlates of 1H MRSI-detected hippocampal abnormalities in temporal lobe epilepsy.
Topics: Adult; Aspartic Acid; Brain Mapping; Cognition Disorders; Creatine; Dominance, Cerebral; Epilepsy, T | 1999 |
Creatine reduces 3-nitropropionic-acid-induced cognitive and motor abnormalities in rats.
Topics: Animals; Behavior, Animal; Cerebral Ventricles; Cognition Disorders; Corpus Striatum; Creatine; Male | 2000 |
Regional metabolic patterns in mild cognitive impairment and Alzheimer's disease: A 1H MRS study.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Aspartic Acid; Brain Mapping; Choline; Cognition Disorde | 2000 |
Correlation of cerebral metabolites with clinical outcome among patients with severe congestive heart failure.
Topics: Aspartic Acid; Brain; Choline; Cognition Disorders; Creatine; Disease Progression; Heart Failure; Hu | 2001 |
(1)H-MR spectroscopy differentiates mild cognitive impairment from normal brain aging.
Topics: Aged; Aged, 80 and over; Aging; Alzheimer Disease; Aspartic Acid; Brain Chemistry; Choline; Cognitio | 2001 |
Decrease of N-acetylaspartate in the MTL correlates with cognitive decline of AD patients.
Topics: Aged; Alzheimer Disease; Aspartic Acid; Cognition Disorders; Creatine; Cross-Sectional Studies; Fema | 2001 |
Hepatitis C and cognitive impairment in a cohort of patients with mild liver disease.
Topics: Adult; Aged; Brain; Choline; Cognition Disorders; Cohort Studies; Creatine; Female; Hepatitis C; Hum | 2002 |