Page last updated: 2024-10-17

creatine and Cardiomegaly

creatine has been researched along with Cardiomegaly in 16 studies

Cardiomegaly: Enlargement of the HEART, usually indicated by a cardiothoracic ratio above 0.50. Heart enlargement may involve the right, the left, or both HEART VENTRICLES or HEART ATRIA. Cardiomegaly is a nonspecific symptom seen in patients with chronic systolic heart failure (HEART FAILURE) or several forms of CARDIOMYOPATHIES.

Research Excerpts

ExcerptRelevanceReference
"Cysteine oxidative modification of cellular proteins is crucial for many aspects of cardiac hypertrophy development."7.88Integrated Dissection of Cysteine Oxidative Post-translational Modification Proteome During Cardiac Hypertrophy. ( Cao, Q; Choi, H; Chung, NC; Garlid, AO; Mirza, B; Ng, DCM; Ping, P; Scruggs, SB; Wang, D; Wang, J, 2018)
" Primary outcome measures were mitochondrial ATP production measured as phosphocreatine recovery by 31Phosphorus magnetic resonance spectroscopy, neurological deficits assessed by the international co-operative ataxia rating scale and cardiac hypertrophy in echocardiography."5.11L-carnitine and creatine in Friedreich's ataxia. A randomized, placebo-controlled crossover trial. ( Abele, M; Colier, WN; Klockgether, T; Kuntz-Hehner, S; Müller, K; Przuntek, H; Schillings, M; Schöls, L; Skipka, G; van Beekvelt, MC; Vorgerd, M; Zange, J, 2005)
"Cysteine oxidative modification of cellular proteins is crucial for many aspects of cardiac hypertrophy development."3.88Integrated Dissection of Cysteine Oxidative Post-translational Modification Proteome During Cardiac Hypertrophy. ( Cao, Q; Choi, H; Chung, NC; Garlid, AO; Mirza, B; Ng, DCM; Ping, P; Scruggs, SB; Wang, D; Wang, J, 2018)
"To address the hypothesis that impaired ATP synthesis rates caused by changes in the creatine kinase system is an important mechanism underlying cardiac failure, we measured total creatine kinase activity, isoenzyme composition and creatine content in two animal models of hypertrophy with cardiac dysfunction, the spontaneously hypertensive rat in the transition to failure and the creatine-depleted hyperthyroid rat heart challenged by hypoxia."3.68Energetic correlates of cardiac failure: changes in the creatine kinase system in the failing myocardium. ( Atkinson, DE; Clarke, K; Fetters, JK; Ingwall, JS, 1990)
"We measured creatine kinase activity, isozyme composition, and total creatine content in biopsy samples of left ventricular myocardium from 34 adults in four groups: subjects with normal left ventricles, patients with left ventricular hypertrophy due to aortic stenosis, patients with coronary artery disease without left ventricular hypertrophy, and patients with coronary artery disease and left ventricular hypertrophy due to aortic stenosis."3.67The creatine kinase system in normal and diseased human myocardium. ( Allen, PD; Fifer, MA; Grossman, W; Ingwall, JS; Kramer, MF; Lorell, BH; Shemin, R, 1985)
" Chronic administration of oxfenicine to dogs for 1 year produced dose-related, nonpathological increases in relative heart weight (up to 85% at 750 mg/kg per day)."1.27Coronary hyperemia and cardiac hypertrophy following inhibition of fatty acid oxidation. Evidence of a regulatory role for cytosolic phosphorylation potential. ( Faccini, JM; Greaves, P; Higgins, AJ, 1985)

Research

Studies (16)

TimeframeStudies, this research(%)All Research%
pre-19908 (50.00)18.7374
1990's3 (18.75)18.2507
2000's2 (12.50)29.6817
2010's3 (18.75)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Wang, J1
Choi, H1
Chung, NC1
Cao, Q1
Ng, DCM1
Mirza, B1
Scruggs, SB1
Wang, D1
Garlid, AO1
Ping, P1
Phillips, D1
Ten Hove, M1
Schneider, JE1
Wu, CO1
Sebag-Montefiore, L1
Aponte, AM1
Lygate, CA1
Wallis, J1
Clarke, K2
Watkins, H1
Balaban, RS1
Neubauer, S1
Shen, W1
Vatner, DE1
Vatner, SF1
Ingwall, JS4
GANGLOFF, EC1
HEMMINGS, IL1
KRAUSE, RF1
JOHNSTON, LC1
GRIEBLE, HG1
SCHOENBERGER, JA1
FULLER, JB1
FOX, AC1
WIKLER, NS1
REED, GE1
Schöls, L1
Zange, J1
Abele, M1
Schillings, M1
Skipka, G1
Kuntz-Hehner, S1
van Beekvelt, MC1
Colier, WN1
Müller, K1
Klockgether, T1
Przuntek, H1
Vorgerd, M1
Srivastava, PM1
Calafiore, P1
Macisaac, RJ1
Patel, SK1
Thomas, MC1
Jerums, G1
Burrell, LM1
Ben Cheikh, R1
Guendouz, A1
Moravec, J1
Lortet, S1
Heckmann, M1
Ray, A1
Rossi, A1
Aussedat, J1
Grably, S1
Zimmer, HG1
Morales, MF1
Stockdale, FE1
Wildenthal, K1
Reilly, PJ1
Cooksey, JD1
Atkinson, DE1
Fetters, JK1
Kramer, MF1
Fifer, MA1
Lorell, BH1
Shemin, R1
Grossman, W1
Allen, PD1
Siehl, D1
Chua, BH1
Lautensack-Belser, N1
Morgan, HE1
Higgins, AJ1
Faccini, JM1
Greaves, P1

Trials

1 trial available for creatine and Cardiomegaly

ArticleYear
L-carnitine and creatine in Friedreich's ataxia. A randomized, placebo-controlled crossover trial.
    Journal of neural transmission (Vienna, Austria : 1996), 2005, Volume: 112, Issue:6

    Topics: Adenosine Triphosphate; Adolescent; Adult; Cardiomegaly; Carnitine; Child; Creatine; Female; Friedre

2005

Other Studies

15 other studies available for creatine and Cardiomegaly

ArticleYear
Integrated Dissection of Cysteine Oxidative Post-translational Modification Proteome During Cardiac Hypertrophy.
    Journal of proteome research, 2018, 12-07, Volume: 17, Issue:12

    Topics: Calcium; Cardiomegaly; Creatine; Cysteine; Glucose; Humans; Oxidation-Reduction; Phosphorylation; Pr

2018
Mice over-expressing the myocardial creatine transporter develop progressive heart failure and show decreased glycolytic capacity.
    Journal of molecular and cellular cardiology, 2010, Volume: 48, Issue:4

    Topics: Animals; Aorta; Cardiomegaly; Creatine; Electrophoresis, Gel, Two-Dimensional; Female; Glycolysis; H

2010
Progressive loss of creatine maintains a near normal DeltaG approximately (ATP) in transgenic mouse hearts with cardiomyopathy caused by overexpressing Gsalpha.
    Journal of molecular and cellular cardiology, 2010, Volume: 48, Issue:4

    Topics: Adenosine Diphosphate; Adenosine Triphosphate; Animals; Cardiomegaly; Cardiomyopathies; Creatine; Cy

2010
Creatine, creatinine, and creatine phosphate in normal and hypertrophied rat hearts.
    The American journal of physiology, 1961, Volume: 201

    Topics: Cardiomegaly; Coenzymes; Creatine; Creatinine; Hypertrophy; Phosphocreatine

1961
TREATMENT OF ARTERIAL HYPERTENSIVE DISEASE WITH DIURETICS. III. CHLORTHALIDONE ALONE AND IN COMBINATION WITH SPIRONOLACTONE.
    The American journal of the medical sciences, 1964, Volume: 247

    Topics: Bendroflumethiazide; Cardiomegaly; Chlorides; Chlorthalidone; Coronary Disease; Creatine; Creatinine

1964
HIGH ENERGY PHOSPHATE COMPOUNDS IN THE MYOCARDIUM DURING EXPERIMENTAL CONGESTIVE HEART FAILURE. PURINE AND PYRIMIDINE NUCLEOTIDES, CREATINE, AND CREATINE PHOSPHATE IN NORMAL AND IN FAILING HEARTS.
    The Journal of clinical investigation, 1965, Volume: 44

    Topics: Adenine Nucleotides; Adenosine Triphosphate; Animals; Biochemical Phenomena; Biochemistry; Cardiomeg

1965
Prevalence and predictors of cardiac hypertrophy and dysfunction in patients with Type 2 diabetes.
    Clinical science (London, England : 1979), 2008, Volume: 114, Issue:4

    Topics: Aging; Analysis of Variance; Antihypertensive Agents; Cardiomegaly; Creatine; Cross-Sectional Studie

2008
Control of oxidative metabolism in volume-overloaded rat hearts: effects of different lipid substrates.
    The American journal of physiology, 1994, Volume: 266, Issue:5 Pt 2

    Topics: Adenosine Diphosphate; Adenosine Triphosphate; Animals; Caprylates; Cardiomegaly; Creatine; Energy M

1994
Energy metabolism response to calcium activation in isolated rat hearts during development and regression of T3-induced hypertrophy.
    Molecular and cellular biochemistry, 1995, Oct-18, Volume: 151, Issue:2

    Topics: Adenosine Diphosphate; Adenosine Triphosphate; Animals; Calcium; Cardiomegaly; Creatine; Energy Meta

1995
Creatine: a possible stimulus skeletal cardiac muscle hypertrophy.
    Recent advances in studies on cardiac structure and metabolism, 1975, Volume: 8

    Topics: Actins; Animals; Cardiomegaly; Chick Embryo; Creatine; Culture Techniques; DNA; Hypertrophy; Leucine

1975
Cardiac energy stores and creatine in experimental cardiac hypertrophy.
    Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.), 1979, Volume: 161, Issue:2

    Topics: Adenosine Triphosphate; Animals; Cardiomegaly; Creatine; Female; Heart Ventricles; Myocardium; Phosp

1979
Energetic correlates of cardiac failure: changes in the creatine kinase system in the failing myocardium.
    European heart journal, 1990, Volume: 11 Suppl B

    Topics: Animals; Cardiac Output, Low; Cardiomegaly; Creatine; Creatine Kinase; Hypoxia; Isoenzymes; Mitochon

1990
The creatine kinase system in normal and diseased human myocardium.
    The New England journal of medicine, 1985, Oct-24, Volume: 313, Issue:17

    Topics: Adult; Aged; Aortic Valve Stenosis; Cardiomegaly; Citrate (si)-Synthase; Coronary Disease; Creatine;

1985
Faster protein and ribosome synthesis in thyroxine-induced hypertrophy of rat heart.
    The American journal of physiology, 1985, Volume: 248, Issue:3 Pt 1

    Topics: Adenine Nucleotides; Amino Acids; Animals; Cardiomegaly; Creatine; Female; Insulin; Perfusion; Phosp

1985
Coronary hyperemia and cardiac hypertrophy following inhibition of fatty acid oxidation. Evidence of a regulatory role for cytosolic phosphorylation potential.
    Advances in myocardiology, 1985, Volume: 6

    Topics: Adenosine Diphosphate; Adenosine Triphosphate; Animals; Cardiomegaly; Coronary Circulation; Creatine

1985