Page last updated: 2024-10-17

creatine and Brain Ischemia

creatine has been researched along with Brain Ischemia in 66 studies

Brain Ischemia: Localized reduction of blood flow to brain tissue due to arterial obstruction or systemic hypoperfusion. This frequently occurs in conjunction with brain hypoxia (HYPOXIA, BRAIN). Prolonged ischemia is associated with BRAIN INFARCTION.

Research Excerpts

ExcerptRelevanceReference
"Serum metabonomic profiles of the model of focal cerebral ischemia reperfusion is established with the suture-occluded method by Longa to study the effect of ginsenosides."7.96[Effect of ginsenosides on serous metabonomic profiles in cerebral ischemia-reperfusion rats based on ~1H-NMR]. ( Cao, DM; Guan, QX; Liu, YL; Wang, SM, 2020)
"Choline and creatine are commonly used as denominators for other metabolites in ischemic stroke spectroscopy, assuming that they do not change."7.74Choline and creatine are not reliable denominators for calculating metabolite ratios in acute ischemic stroke. ( Armitage, PA; Bastin, ME; Cvoro, V; Marshall, I; Muñoz Maniega, S; Wardlaw, JM, 2008)
"Phosphocreatine is a major cellular source of high energy phosphates, which is crucial to maintain cell viability under conditions of impaired metabolic states, such as decreased oxygen and energy availability (i."5.38FTIR imaging of brain tissue reveals crystalline creatine deposits are an ex vivo marker of localized ischemia during murine cerebral malaria: general implications for disease neurochemistry. ( Carter, EA; El-Assaad, F; Grau, GE; Hackett, MJ; Hunt, NH; Lay, PA; Lee, J; McQuillan, JA, 2012)
" We decided to administer it by intracerebroventricular infusion, to maximize its bioavailability to the brain."5.33Intracerebroventricular administration of creatine protects against damage by global cerebral ischemia in rat. ( Balestrino, M; Gandolfo, C; Izvarina, N; Korzhevskii, DE; Kostkin, VB; Lensman, M; Mourovets, VO; Otellin, VA; Perasso, L; Polenov, SA, 2006)
"Serum metabonomic profiles of the model of focal cerebral ischemia reperfusion is established with the suture-occluded method by Longa to study the effect of ginsenosides."3.96[Effect of ginsenosides on serous metabonomic profiles in cerebral ischemia-reperfusion rats based on ~1H-NMR]. ( Cao, DM; Guan, QX; Liu, YL; Wang, SM, 2020)
"Choline and creatine are commonly used as denominators for other metabolites in ischemic stroke spectroscopy, assuming that they do not change."3.74Choline and creatine are not reliable denominators for calculating metabolite ratios in acute ischemic stroke. ( Armitage, PA; Bastin, ME; Cvoro, V; Marshall, I; Muñoz Maniega, S; Wardlaw, JM, 2008)
" T2 weighted-imaging (T2WI) and 1H-magnetic resonance spectroscopy (1H-MRS) were performed, to study the changes of the imaging and the neuronal metabolites N-acetyl aspartate (NAA), creatine/phosphocreatine (Cr/PCr), choline (Cho) and lactose (Lac) in cerebrum following cerebral ischemia."3.72[The effects of Erigeron breviscapus preparation on the imaging and neuronal metabolites at the early time points after reperfusion following the ischemic cerebral injury in rats]. ( Fan, M; Li, LY; Liao, WJ; Liu, ML; Yang, WT; Yang, YH, 2003)
"The apparent diffusion coefficient (ADC) of choline-containing compounds (Cho), creatine and phosphocreatine (Cre), N-acetyl-aspartate (NAA), lactate, and water was measured in normal rat brain, and in the ischemic and contralateral region of rat brain approximately 3 and 24 h after induction of focal cerebral ischemia."3.69Diffusion of metabolites in normal and ischemic rat brain measured by localized 1H MRS. ( Dijkhuizen, RM; Nicolay, K; Tulleken, CA; van der Toorn, A, 1996)
" First, in patients with cerebral infarctions, increased concentrations of lactate were found in the majority of patients, and N-acetyl aspartate (NAA) was reduced to a significantly greater extent than choline (Cho) or creatine (Cre)."3.68Proton magnetic resonance spectroscopy of human brain: applications to normal white matter, chronic infarction, and MRI white matter signal hyperintensities. ( Calabrese, G; Deicken, R; Fein, G; Fisher, SN; Hetherington, HP; Sappey-Marinier, D; Van Dyke, C; Weiner, MW, 1992)
"Phosphocreatine (PCr) has been administered after human MI, where it proved to be safe and probably helpful."2.49Therapeutic use of creatine in brain or heart ischemia: available data and future perspectives. ( Balestrino, M; Gandolfo, C; Perasso, L; Ruggeri, P; Spallarossa, P, 2013)
"In this study, we used a global cerebral ischemia induced by four-vessel occlusion as an established animal model for ischemic stroke to investigate metabolic changes after 24 h reperfusion, when transitions occur due to the onset of delayed neuronal death."1.48NMR metabolomic study of blood plasma in ischemic and ischemically preconditioned rats: an increased level of ketone bodies and decreased content of glycolytic products 24 h after global cerebral ischemia. ( Baranovicova, E; Cierny, D; Grendar, M; Kalenska, D; Lehotsky, J; Tomascova, A, 2018)
"Phosphocreatine is a major cellular source of high energy phosphates, which is crucial to maintain cell viability under conditions of impaired metabolic states, such as decreased oxygen and energy availability (i."1.38FTIR imaging of brain tissue reveals crystalline creatine deposits are an ex vivo marker of localized ischemia during murine cerebral malaria: general implications for disease neurochemistry. ( Carter, EA; El-Assaad, F; Grau, GE; Hackett, MJ; Hunt, NH; Lay, PA; Lee, J; McQuillan, JA, 2012)
"We utilized a global cerebral ischemia model induced by arresting the heart with a combination of hypovolemia and intracardiac injections of a cold potassium chloride solution in order to study the potential therapeutic benefits of human mesenchymal stem cells (hMSCs) on global cerebral ischemia."1.36Therapeutic benefits of human mesenchymal stem cells derived from bone marrow after global cerebral ischemia. ( Hamada, H; Harada, K; Honmou, O; Houkin, K; Kocsis, JD; Liu, H; Miyata, K; Suzuki, J; Zheng, W, 2010)
"We used a mouse model of transient middle cerebral artery occlusion."1.35In vivo neuroprotection by a creatine-derived compound: phosphocreatine-Mg-complex acetate. ( Adriano, E; Balestrino, M; Burov, SV; Gandolfo, C; Perasso, L; Ruggeri, P, 2009)
" We decided to administer it by intracerebroventricular infusion, to maximize its bioavailability to the brain."1.33Intracerebroventricular administration of creatine protects against damage by global cerebral ischemia in rat. ( Balestrino, M; Gandolfo, C; Izvarina, N; Korzhevskii, DE; Kostkin, VB; Lensman, M; Mourovets, VO; Otellin, VA; Perasso, L; Polenov, SA, 2006)
"GbE could prevent and treat acute cerebral ischemia."1.32Effects of Ginkgo biloba extract on acute cerebral ischemia in rats analyzed by magnetic resonance spectroscopy. ( Li, YF; Peng, H; Sun, SG, 2003)
"Creatine was infused intraventricularly to 11 animals using an automatic Alzet osmotic minipump."1.32[Structural characteristics of astrocytes from the rat hippocampus in postischemia]. ( Balestrino, M; Grigor'ev, IP; Korzhevskiĭ, DE; Kostkin, VB; Lentsman, MV; Otellin, VA; Polenov, SA, 2004)
"Subcortical ischemic vascular dementia is associated with cortical hypometabolism and hypoperfusion, and this reduced cortical metabolism or blood flow can be detected with functional imaging such as positron emission tomography."1.31Subcortical ischemic vascular dementia: assessment with quantitative MR imaging and 1H MR spectroscopy. ( Amend, DL; Capizzano, AA; Chui, HC; Fein, G; Jagust, W; Maudsley, AA; Norman, D; Schuff, N; Segal, MR; Tanabe, JL; Weiner, MW, 2000)

Research

Studies (66)

TimeframeStudies, this research(%)All Research%
pre-19903 (4.55)18.7374
1990's21 (31.82)18.2507
2000's23 (34.85)29.6817
2010's16 (24.24)24.3611
2020's3 (4.55)2.80

Authors

AuthorsStudies
Laredo, C1
Rodríguez, A1
Oleaga, L1
Hernández-Pérez, M1
Renú, A1
Puig, J1
Román, LS1
Planas, AM1
Urra, X1
Chamorro, Á1
Genovese, G1
Diaz-Fernandez, B1
Lejeune, FX1
Ronen, I1
Marjańska, M1
Yahia-Cherif, L1
Lehéricy, S1
Branzoli, F1
Rosso, C1
Cao, DM1
Guan, QX1
Liu, YL1
Wang, SM1
Baranovicova, E1
Grendar, M1
Kalenska, D1
Tomascova, A1
Cierny, D1
Lehotsky, J1
Gasparovic, C1
Prestopnik, J1
Thompson, J1
Taheri, S1
Huisa, B1
Schrader, R1
Adair, JC1
Rosenberg, GA2
Guan, YM1
Zhu, Y1
Liu, XC1
Huang, HL1
Wang, ZW1
Liu, B1
Zhu, YZ1
Wang, QS1
Shemesh, N1
Rosenberg, JT1
Dumez, JN1
Grant, SC1
Frydman, L1
Hackett, MJ2
Britz, CJ1
Paterson, PG1
Nichol, H1
Pickering, IJ1
George, GN1
Kolpakova, ME1
Veselkina, OS2
Vlasov, TD2
Bivard, A1
Yassi, N1
Krishnamurthy, V1
Lin, L1
Levi, C1
Spratt, NJ1
Mittef, F1
Davis, S1
Parsons, M1
Auriel, E1
Kliper, E1
Shenhar-Tsarfaty, S1
Molad, J1
Berliner, S1
Shapira, I1
Ben-Bashat, D1
Shopin, L1
Tene, O1
Bornstein, NM1
Ben Assayag, E1
Jiménez-Xarrié, E1
Davila, M1
Candiota, AP1
Delgado-Mederos, R1
Ortega-Martorell, S1
Julià-Sapé, M1
Arús, C1
Martí-Fàbregas, J1
Muñoz Maniega, S1
Cvoro, V1
Armitage, PA2
Marshall, I3
Bastin, ME1
Wardlaw, JM3
Perasso, L4
Adriano, E1
Ruggeri, P2
Burov, SV2
Gandolfo, C3
Balestrino, M5
Zheng, W1
Honmou, O1
Miyata, K1
Harada, K1
Suzuki, J1
Liu, H1
Houkin, K2
Hamada, H1
Kocsis, JD1
Karaszewski, B1
Thomas, RG1
Chappell, FM1
Carpenter, TK1
Lymer, GK1
Dennis, MS1
Chefu, SG1
Baĭsa, AE1
Leko, MV1
Mullins, ME1
Zheng, DD1
Liu, ZH1
Fang, J1
Wang, XY1
Zhang, J1
Spallarossa, P1
Lee, J1
El-Assaad, F1
McQuillan, JA1
Carter, EA1
Grau, GE1
Hunt, NH1
Lay, PA1
Lensman, M2
Parodi, M1
Rebaudo, R1
Melani, R1
Polenov, S1
Cupello, A1
Macmillan, CS1
Wild, JM1
Andrews, PJ1
Easton, VJ1
Schwarcz, A1
Natt, O1
Watanabe, T1
Boretius, S1
Frahm, J3
Michaelis, T2
Peng, H1
Li, YF1
Sun, SG1
Lei, H1
Zhang, Y1
Zhu, XH1
Chen, W1
Liao, WJ1
Yang, YH1
Fan, M1
Yang, WT1
Li, LY1
Liu, ML1
Zhu, S1
Li, M1
Figueroa, BE1
Liu, A1
Stavrovskaya, IG1
Pasinelli, P1
Beal, MF1
Brown, RH1
Kristal, BS1
Ferrante, RJ1
Friedlander, RM1
Korzhevskiĭ, DE2
Otellin, VA2
Grigor'ev, IP1
Kostkin, VB2
Polenov, SA2
Lentsman, MV1
Marmarou, A1
Signoretti, S1
Fatouros, P1
Aygok, GA1
Bullock, R1
Prass, K1
Royl, G1
Lindauer, U1
Freyer, D1
Megow, D1
Dirnagl, U1
Stöckler-Ipsiroglu, G1
Wallimann, T1
Priller, J1
Mourovets, VO1
Izvarina, N1
Glodzik-Sobanska, L1
Li, J1
Mosconi, L1
Slowik, A1
Walecki, J1
Szczudlik, A1
Sobiecka, B1
de Leon, MJ1
Nitkunan, A1
Charlton, RA1
McIntyre, DJ1
Barrick, TR1
Howe, FA1
Markus, HS1
Whittingham, TS1
Lust, WD1
Passonneau, JV1
Woznicki, DT1
Walker, JB1
Constans, JM2
Meyerhoff, DJ2
Gerson, J1
MacKay, S2
Norman, D3
Fein, G4
Weiner, MW6
Wick, M2
Nagatomo, Y1
Prielmeier, F1
van der Toorn, A2
Verheul, HB1
Berkelbach van der Sprenkel, JW1
Tulleken, CA2
Nicolay, K2
Federico, F2
Conte, C2
Simone, IL1
Giannini, P1
Liguori, M1
Picciola, E1
Tortorella, C1
Ferrari, E1
Kamada, K1
Hida, K1
Matsuzawa, H1
Iwasaki, Y1
Abe, H1
Nakada, T1
van Zijl, PC1
Moonen, CT1
Bourgeois, D1
Kozlowski, P1
Lauriero, F1
Rubini, G1
Simone, I1
Inchingolo, V1
d'Addabbo, A1
Dijkhuizen, RM1
Higuchi, T2
Graham, SH1
Fernandez, EJ2
Rooney, WD1
Gaspary, HL1
Maudsley, AA3
Harada, M3
Miyoshi, H1
Ootsuka, H1
Taoka, Y1
Tanouchi, M1
Nishitani, H2
Sibbitt, WL1
Haseler, LJ1
Griffey, RR1
Friedman, SD1
Brooks, WM1
Sengar, AR1
Gupta, RK1
Dhanuka, AK1
Roy, R1
Das, K1
Fujimori, H1
Nonaka, M1
Yoshimine, T1
Kohmura, E1
Wakayama, A1
Yamashita, T1
Hayakawa, T1
Toner, CC1
Stamford, JA1
Vahedi, K1
Domigo, V1
Amarenco, P1
Bousser, MG1
George, AE1
Cha, S1
Capizzano, AA1
Schuff, N1
Amend, DL1
Tanabe, JL1
Jagust, W1
Chui, HC1
Segal, MR1
Kim, GE1
Lee, JH1
Cho, YP1
Kim, ST1
Son, BC1
Park, CK1
Choi, BG1
Kim, EN1
Choe, BY1
Lee, KS1
Kim, MC1
Kang, JK1
Uno, M2
Nagahiro, S1
Massieu, L1
Del Río, P1
Montiel, T1
Hong, F1
Hisaoka, S1
Matsuda, T1
Lebedev, VV1
Iunovidov, IM1
Smirnova, EL1
Wang, Z1
Bogdan, AR1
Zimmerman, RA1
Gusnard, DA1
Leigh, JS1
Ohene-Frempong, K1
Gideon, P1
Henriksen, O1
Sappey-Marinier, D1
Calabrese, G1
Hetherington, HP1
Fisher, SN1
Deicken, R1
Van Dyke, C1

Clinical Trials (3)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
CHemical OptImization of Cerebral Embolectomy in Patients With Acute Stroke Treated With Mechanical Thrombectomy 2 (CHOICE 2 TRIAL)[NCT05797792]Phase 3440 participants (Anticipated)Interventional2023-06-01Not yet recruiting
MRI for Early Identification of Underlying Pathology in Patients With Acute Intracerebral Hemorrhage[NCT01689402]60 participants (Actual)Observational2012-04-30Completed
Libman-Sacks Endocarditis as a Cause of Neuropsychiatric Systemic Lupus Erythematosus[NCT00858884]68 participants (Actual)Interventional2006-08-31Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

3 reviews available for creatine and Brain Ischemia

ArticleYear
[Creatine in a metabolism of cell and its protective action at brain ischemia].
    Rossiiskii fiziologicheskii zhurnal imeni I.M. Sechenova, 2013, Volume: 99, Issue:8

    Topics: Blood-Brain Barrier; Brain Ischemia; Creatine; Energy Metabolism; Humans; Hypoxia; Membrane Transpor

2013
Therapeutic use of creatine in brain or heart ischemia: available data and future perspectives.
    Medicinal research reviews, 2013, Volume: 33, Issue:2

    Topics: Blood-Brain Barrier; Brain Ischemia; Cardiotonic Agents; Creatine; Female; Forecasting; Humans; In V

2013
Role of creatine and phosphocreatine in neuronal protection from anoxic and ischemic damage.
    Amino acids, 2002, Volume: 23, Issue:1-3

    Topics: Adenosine Triphosphate; Animals; Blood-Brain Barrier; Brain Ischemia; Creatine; Glucose; Hippocampus

2002

Trials

2 trials available for creatine and Brain Ischemia

ArticleYear
Adjunct Thrombolysis Enhances Brain Reperfusion following Successful Thrombectomy.
    Annals of neurology, 2022, Volume: 92, Issue:5

    Topics: Aged; Aged, 80 and over; Brain; Brain Ischemia; Cerebral Infarction; Creatine; Endovascular Procedur

2022
Mitochondrial injury measured by proton magnetic resonance spectroscopy in severe head trauma patients.
    Acta neurochirurgica. Supplement, 2005, Volume: 95

    Topics: Adult; Aspartic Acid; Biomarkers; Brain; Brain Ischemia; Choline; Craniocerebral Trauma; Creatine; F

2005

Other Studies

61 other studies available for creatine and Brain Ischemia

ArticleYear
Longitudinal Monitoring of Microstructural Alterations in Cerebral Ischemia with in Vivo Diffusion-weighted MR Spectroscopy.
    Radiology, 2023, Volume: 306, Issue:3

    Topics: Brain Ischemia; Choline; Creatine; Female; Humans; Ischemic Stroke; Longitudinal Studies; Magnetic R

2023
[Effect of ginsenosides on serous metabonomic profiles in cerebral ischemia-reperfusion rats based on ~1H-NMR].
    Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica, 2020, Volume: 45, Issue:5

    Topics: 3-Hydroxybutyric Acid; Animals; Brain Ischemia; Creatine; Ginsenosides; Hemolymph; Metabolome; Phosp

2020
NMR metabolomic study of blood plasma in ischemic and ischemically preconditioned rats: an increased level of ketone bodies and decreased content of glycolytic products 24 h after global cerebral ischemia.
    Journal of physiology and biochemistry, 2018, Volume: 74, Issue:3

    Topics: Acetic Acid; Animals; Biomarkers; Blood Glucose; Brain Ischemia; Cerebrovascular Disorders; Creatine

2018
1H-MR spectroscopy metabolite levels correlate with executive function in vascular cognitive impairment.
    Journal of neurology, neurosurgery, and psychiatry, 2013, Volume: 84, Issue:7

    Topics: Aged; Aged, 80 and over; Alzheimer Disease; Aspartic Acid; Biomarkers; Brain Ischemia; Choline; Cogn

2013
Effect of human umbilical cord blood mesenchymal stem cell transplantation on neuronal metabolites in ischemic rabbits.
    BMC neuroscience, 2014, Mar-17, Volume: 15

    Topics: Animals; Aspartic Acid; Brain; Brain Ischemia; Choline; Cord Blood Stem Cell Transplantation; Creati

2014
Metabolic T1 dynamics and longitudinal relaxation enhancement in vivo at ultrahigh magnetic fields on ischemia.
    Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 2014, Volume: 34, Issue:11

    Topics: Animals; Aspartic Acid; Brain Ischemia; Cerebral Angiography; Cerebrovascular Circulation; Choline;

2014
In situ biospectroscopic investigation of rapid ischemic and postmortem induced biochemical alterations in the rat brain.
    ACS chemical neuroscience, 2015, Feb-18, Volume: 6, Issue:2

    Topics: Animals; Brain Ischemia; Cerebellum; Creatine; Decapitation; Dissection; Disulfides; Freezing; Lacti

2015
A comprehensive analysis of metabolic changes in the salvaged penumbra.
    Neuroradiology, 2016, Volume: 58, Issue:4

    Topics: Adult; Aged; Aged, 80 and over; Brain Ischemia; Case-Control Studies; Creatine; Female; Glutamic Aci

2016
Impaired renal function is associated with brain atrophy and poststroke cognitive decline.
    Neurology, 2016, 05-24, Volume: 86, Issue:21

    Topics: Aged; Atrophy; Brain; Brain Ischemia; Cognitive Dysfunction; Creatine; Diffusion Tensor Imaging; Fem

2016
Brain metabolic pattern analysis using a magnetic resonance spectra classification software in experimental stroke.
    BMC neuroscience, 2017, 01-13, Volume: 18, Issue:1

    Topics: Animals; Brain; Brain Ischemia; Creatine; Image Processing, Computer-Assisted; Inositol; Lactic Acid

2017
Choline and creatine are not reliable denominators for calculating metabolite ratios in acute ischemic stroke.
    Stroke, 2008, Volume: 39, Issue:9

    Topics: Acute Disease; Aged; Aged, 80 and over; Biomarkers; Brain; Brain Ischemia; Choline; Creatine; Down-R

2008
In vivo neuroprotection by a creatine-derived compound: phosphocreatine-Mg-complex acetate.
    Brain research, 2009, Aug-18, Volume: 1285

    Topics: Animals; Brain Infarction; Brain Ischemia; Creatine; Cytoprotection; Disease Models, Animal; Infarct

2009
Therapeutic benefits of human mesenchymal stem cells derived from bone marrow after global cerebral ischemia.
    Brain research, 2010, Jan-15, Volume: 1310

    Topics: Analysis of Variance; Animals; Bone Marrow Cells; Brain Ischemia; Brain-Derived Neurotrophic Factor;

2010
Brain choline concentration. Early quantitative marker of ischemia and infarct expansion?
    Neurology, 2010, Sep-07, Volume: 75, Issue:10

    Topics: Aged; Aged, 80 and over; Brain; Brain Ischemia; Brain Mapping; Cerebral Infarction; Choline; Creatin

2010
[Amides of creatine: perspectives of neuroprotection].
    Rossiiskii fiziologicheskii zhurnal imeni I.M. Sechenova, 2011, Volume: 97, Issue:7

    Topics: Amides; Animals; Brain Ischemia; Creatine; Female; gamma-Aminobutyric Acid; Glycine; Hemodynamics; I

2011
Daydreaming about our metaphorical tool belt.
    AJNR. American journal of neuroradiology, 2012, Volume: 33, Issue:3

    Topics: Aging; Aspartic Acid; Brain; Brain Ischemia; Choline; Creatine; Female; Humans; Male

2012
The effect of age and cerebral ischemia on diffusion-weighted proton MR spectroscopy of the human brain.
    AJNR. American journal of neuroradiology, 2012, Volume: 33, Issue:3

    Topics: Adult; Aging; Aspartic Acid; Brain; Brain Ischemia; Choline; Creatine; Female; Humans; Male; Reprodu

2012
FTIR imaging of brain tissue reveals crystalline creatine deposits are an ex vivo marker of localized ischemia during murine cerebral malaria: general implications for disease neurochemistry.
    ACS chemical neuroscience, 2012, Dec-19, Volume: 3, Issue:12

    Topics: Animals; Biomarkers; Brain; Brain Ischemia; Creatine; Malaria, Cerebral; Mice; Phosphocreatine; Spec

2012
Traumatic brain injury and subarachnoid hemorrhage: in vivo occult pathology demonstrated by magnetic resonance spectroscopy may not be "ischaemic". A primary study and review of the literature.
    Acta neurochirurgica, 2002, Volume: 144, Issue:9

    Topics: Adolescent; Adult; Aspartic Acid; Brain; Brain Injuries; Brain Ischemia; Child; Choline; Creatine; C

2002
Localized proton MRS of cerebral metabolite profiles in different mouse strains.
    Magnetic resonance in medicine, 2003, Volume: 49, Issue:5

    Topics: Animals; Aspartic Acid; Brain; Brain Ischemia; Choline; Creatine; Magnetic Resonance Spectroscopy; M

2003
Effects of Ginkgo biloba extract on acute cerebral ischemia in rats analyzed by magnetic resonance spectroscopy.
    Acta pharmacologica Sinica, 2003, Volume: 24, Issue:5

    Topics: Animals; Aspartic Acid; Brain Ischemia; Choline; Creatine; Drugs, Chinese Herbal; Ginkgo biloba; Hip

2003
Changes in the proton T2 relaxation times of cerebral water and metabolites during forebrain ischemia in rat at 9.4 T.
    Magnetic resonance in medicine, 2003, Volume: 49, Issue:6

    Topics: Animals; Aspartic Acid; Brain Ischemia; Creatine; Linear Models; Magnetic Resonance Spectroscopy; Ma

2003
[The effects of Erigeron breviscapus preparation on the imaging and neuronal metabolites at the early time points after reperfusion following the ischemic cerebral injury in rats].
    Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica, 2003, Volume: 28, Issue:2

    Topics: Animals; Aspartic Acid; Asteraceae; Brain; Brain Ischemia; Choline; Creatine; Drugs, Chinese Herbal;

2003
Prophylactic creatine administration mediates neuroprotection in cerebral ischemia in mice.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 2004, Jun-30, Volume: 24, Issue:26

    Topics: Adenosine Triphosphate; Administration, Oral; Animals; Apoptosis; Brain Ischemia; Caspase 3; Caspase

2004
[Structural characteristics of astrocytes from the rat hippocampus in postischemia].
    Morfologiia (Saint Petersburg, Russia), 2004, Volume: 125, Issue:2

    Topics: Animals; Astrocytes; Brain Ischemia; Creatine; Glial Fibrillary Acidic Protein; Hippocampus; Male; N

2004
Improved reperfusion and neuroprotection by creatine in a mouse model of stroke.
    Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 2007, Volume: 27, Issue:3

    Topics: Adenosine Triphosphate; Animals; Brain; Brain Ischemia; Cerebrovascular Circulation; Creatine; Disea

2007
Intracerebroventricular administration of creatine protects against damage by global cerebral ischemia in rat.
    Brain research, 2006, Oct-09, Volume: 1114, Issue:1

    Topics: Animals; Brain Ischemia; Cerebral Infarction; Creatine; Disease Models, Animal; Drug Administration

2006
Prefrontal N-acetylaspartate and poststroke recovery: a longitudinal proton spectroscopy study.
    AJNR. American journal of neuroradiology, 2007, Volume: 28, Issue:3

    Topics: Aged; Aged, 80 and over; Aspartic Acid; Brain Ischemia; Creatine; Female; Follow-Up Studies; Functio

2007
Diffusion tensor imaging and MR spectroscopy in hypertension and presumed cerebral small vessel disease.
    Magnetic resonance in medicine, 2008, Volume: 59, Issue:3

    Topics: Aged; Aspartic Acid; Brain Diseases; Brain Ischemia; Case-Control Studies; Cerebrovascular Circulati

2008
An in vitro model of ischemia: metabolic and electrical alterations in the hippocampal slice.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 1984, Volume: 4, Issue:3

    Topics: Adenosine Monophosphate; Adenosine Triphosphate; Animals; Brain Ischemia; Creatine; Cyclic AMP; Cycl

1984
Utilization of cyclocreatine phosphate, and analogue of creatine phosphate, by mouse brain during ischemia and its sparing action on brain energy reserves.
    Journal of neurochemistry, 1980, Volume: 34, Issue:5

    Topics: Adenosine Triphosphate; Animals; Aspartic Acid; Brain; Brain Ischemia; Creatine; Energy Metabolism;

1980
H-1 MR spectroscopic imaging of white matter signal hyperintensities: Alzheimer disease and ischemic vascular dementia.
    Radiology, 1995, Volume: 197, Issue:2

    Topics: Aged; Alzheimer Disease; Aspartic Acid; Brain; Brain Diseases; Brain Ischemia; Case-Control Studies;

1995
Alteration of intracellular metabolite diffusion in rat brain in vivo during ischemia and reperfusion.
    Stroke, 1995, Volume: 26, Issue:10

    Topics: Animals; Aspartic Acid; Body Water; Brain; Brain Ischemia; Choline; Creatine; Diffusion; Inositol; I

1995
Changes in metabolites and tissue water status after focal ischemia in cat brain assessed with localized proton MR spectroscopy.
    Magnetic resonance in medicine, 1994, Volume: 32, Issue:6

    Topics: Animals; Aspartic Acid; Body Water; Brain; Brain Ischemia; Cats; Creatine; Diffusion; Female; Lactat

1994
Proton magnetic resonance spectroscopy in patients with ischemic stroke.
    Italian journal of neurological sciences, 1994, Volume: 15, Issue:8

    Topics: Adult; Aged; Aspartic Acid; Brain; Brain Ischemia; Case-Control Studies; Choline; Creatine; Female;

1994
Localized proton spectroscopy of focal brain pathology in humans: significant effects of edema on spin-spin relaxation time.
    Magnetic resonance in medicine, 1994, Volume: 31, Issue:5

    Topics: Adult; Aged; Aspartic Acid; Astrocytoma; Brain; Brain Edema; Brain Ischemia; Brain Neoplasms; Cerebr

1994
In situ changes in purine nucleotide and N-acetyl concentrations upon inducing global ischemia in cat brain.
    Magnetic resonance in medicine, 1993, Volume: 29, Issue:3

    Topics: Acetylation; Adenosine; Animals; Aspartic Acid; Brain Ischemia; Cats; Choline; Creatine; Female; gam

1993
A highly sensitive lactate editing technique for surface coil spectroscopic imaging in vivo.
    Magnetic resonance in medicine, 1993, Volume: 29, Issue:3

    Topics: Animals; Aspartic Acid; Brain; Brain Ischemia; Choline; Creatine; Electron Spin Resonance Spectrosco

1993
Regional gray and white matter metabolite differences in subjects with AD, with subcortical ischemic vascular dementia, and elderly controls with 1H magnetic resonance spectroscopic imaging.
    Archives of neurology, 1996, Volume: 53, Issue:2

    Topics: Aged; Aged, 80 and over; Alzheimer Disease; Analysis of Variance; Aspartic Acid; Brain; Brain Ischem

1996
99Tcm-HMPAO SPET and 1H-MRS (proton magnetic resonance spectroscopy) in patients with ischaemic cerebral infarction.
    Nuclear medicine communications, 1996, Volume: 17, Issue:2

    Topics: Adult; Aged; Aspartic Acid; Brain Ischemia; Cerebral Infarction; Cerebrovascular Circulation; Cholin

1996
Diffusion of metabolites in normal and ischemic rat brain measured by localized 1H MRS.
    Magnetic resonance in medicine, 1996, Volume: 36, Issue:6

    Topics: Animals; Aspartic Acid; Brain; Brain Ischemia; Choline; Creatine; Diffusion; Lactic Acid; Magnetic R

1996
Effects of severe global ischemia on N-acetylaspartate and other metabolites in the rat brain.
    Magnetic resonance in medicine, 1997, Volume: 37, Issue:6

    Topics: Alanine; Animals; Aspartic Acid; Brain; Brain Ischemia; Creatine; Lactic Acid; Magnetic Resonance Im

1997
[Accuracy and clinical utility of quantitative proton magnetic resonance spectroscopy (MRS) on phantom and chronic cerebral ischemia].
    Nihon Igaku Hoshasen Gakkai zasshi. Nippon acta radiologica, 1997, Volume: 57, Issue:8

    Topics: Aspartic Acid; Brain; Brain Ischemia; Chronic Disease; Creatine; Humans; Magnetic Resonance Spectros

1997
Neurometabolism of active neuropsychiatric lupus determined with proton MR spectroscopy.
    AJNR. American journal of neuroradiology, 1997, Volume: 18, Issue:7

    Topics: Adult; Aspartic Acid; Brain; Brain Damage, Chronic; Brain Ischemia; Brain Mapping; Choline; Creatine

1997
MR imaging, MR angiography, and MR spectroscopy of the brain in eclampsia.
    AJNR. American journal of neuroradiology, 1997, Volume: 18, Issue:8

    Topics: Adolescent; Adult; Aspartic Acid; Brain; Brain Edema; Brain Ischemia; Cerebral Arteries; Choline; Cr

1997
Proton T2 relaxation of cerebral metabolites during transient global ischemia in rat brain.
    Magnetic resonance in medicine, 1998, Volume: 39, Issue:4

    Topics: Animals; Aspartic Acid; Brain; Brain Ischemia; Choline; Creatine; Image Processing, Computer-Assiste

1998
Changes in brain organic osmolytes in experimental cerebral ischemia.
    Journal of the neurological sciences, 1998, Apr-15, Volume: 157, Issue:1

    Topics: Alanine; Amino Acids; Animals; Aspartic Acid; Brain Chemistry; Brain Ischemia; Creatine; Disease Mod

1998
Effects of metabolic alterations on dopamine release in an in vitro model of neostriatal ischaemia.
    Brain research bulletin, 1999, Mar-01, Volume: 48, Issue:4

    Topics: Animals; Brain Ischemia; Creatine; Dopamine; Electrophysiology; Hypoxia; In Vitro Techniques; Male;

1999
Ischaemic stroke in a sportsman who consumed MaHuang extract and creatine monohydrate for body building.
    Journal of neurology, neurosurgery, and psychiatry, 2000, Volume: 68, Issue:1

    Topics: Adult; Brain Ischemia; Creatine; Ephedra sinica; Ephedrine; Humans; Male; Plant Preparations; Stroke

2000
Applying functional MR imaging to brain-behavioral research: can we do better than simple clinical measures?
    AJNR. American journal of neuroradiology, 2000, Volume: 21, Issue:4

    Topics: Aspartic Acid; Brain; Brain Ischemia; Creatine; Dementia, Vascular; Humans; Magnetic Resonance Imagi

2000
Subcortical ischemic vascular dementia: assessment with quantitative MR imaging and 1H MR spectroscopy.
    AJNR. American journal of neuroradiology, 2000, Volume: 21, Issue:4

    Topics: Aged; Aspartic Acid; Brain Ischemia; Creatine; Dementia, Vascular; Female; Humans; Magnetic Resonanc

2000
Metabolic changes in the ischemic penumbra after carotid endarterectomy in stroke patients by localized in vivo proton magnetic resonance spectroscopy (1H-MRS).
    Cardiovascular surgery (London, England), 2001, Volume: 9, Issue:4

    Topics: Aged; Aspartic Acid; Brain Ischemia; Carotid Stenosis; Cerebral Infarction; Choline; Creatine; Endar

2001
Metabolic changes in pericontusional oedematous areas in mild head injury evaluated by 1H MRS.
    Acta neurochirurgica. Supplement, 2000, Volume: 76

    Topics: Adolescent; Adult; Aged; Aspartic Acid; Brain; Brain Concussion; Brain Edema; Brain Ischemia; Creati

2000
Quantitative evaluation of cerebral metabolites and cerebral blood flow in patients with carotid stenosis.
    Neurological research, 2001, Volume: 23, Issue:6

    Topics: Adult; Aged; Aging; Aspartic Acid; Basal Ganglia; Brain Ischemia; Carotid Stenosis; Cerebral Cortex;

2001
Neurotoxicity of glutamate uptake inhibition in vivo: correlation with succinate dehydrogenase activity and prevention by energy substrates.
    Neuroscience, 2001, Volume: 106, Issue:4

    Topics: 3-Hydroxybutyric Acid; Acetoacetates; Amino Acid Transport System X-AG; Animals; Brain Ischemia; Con

2001
Diffusion-weighted in vivo localized proton MR spectroscopy of human cerebral ischemia and tumor.
    NMR in biomedicine, 2002, Volume: 15, Issue:1

    Topics: Adult; Aspartic Acid; Brain Ischemia; Brain Neoplasms; Cerebral Infarction; Creatine; Diffusion; Fem

2002
[Functional state of the kidneys in patients with acute cerebrovascular disorders].
    Zhurnal nevropatologii i psikhiatrii imeni S.S. Korsakova (Moscow, Russia : 1952), 1978, Volume: 78, Issue:9

    Topics: Acute Disease; Adult; Aged; Blood Pressure; Brain Ischemia; Cerebral Hemorrhage; Creatine; Creatinin

1978
Investigation of stroke in sickle cell disease by 1H nuclear magnetic resonance spectroscopy.
    Neuroradiology, 1992, Volume: 35, Issue:1

    Topics: Adolescent; Adult; Anemia, Sickle Cell; Aspartic Acid; Atrophy; Brain; Brain Ischemia; Cerebral Infa

1992
1H spectroscopic imaging of rat brain at 7 tesla.
    Magnetic resonance in medicine, 1992, Volume: 25, Issue:1

    Topics: Amino Acids; Animals; Aspartic Acid; Brain; Brain Ischemia; Choline; Creatine; Glutamates; Glutamic

1992
In vivo relaxation of N-acetyl-aspartate, creatine plus phosphocreatine, and choline containing compounds during the course of brain infarction: a proton MRS study.
    Magnetic resonance imaging, 1992, Volume: 10, Issue:6

    Topics: Adult; Aged; Aged, 80 and over; Aspartic Acid; Brain Ischemia; Choline; Creatine; Humans; Magnetic R

1992
Proton magnetic resonance spectroscopy of human brain: applications to normal white matter, chronic infarction, and MRI white matter signal hyperintensities.
    Magnetic resonance in medicine, 1992, Volume: 26, Issue:2

    Topics: Aged; Aged, 80 and over; Aspartic Acid; Brain; Brain Chemistry; Brain Ischemia; Cerebral Infarction;

1992