creatine has been researched along with Brain Ischemia in 66 studies
Brain Ischemia: Localized reduction of blood flow to brain tissue due to arterial obstruction or systemic hypoperfusion. This frequently occurs in conjunction with brain hypoxia (HYPOXIA, BRAIN). Prolonged ischemia is associated with BRAIN INFARCTION.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Serum metabonomic profiles of the model of focal cerebral ischemia reperfusion is established with the suture-occluded method by Longa to study the effect of ginsenosides." | 7.96 | [Effect of ginsenosides on serous metabonomic profiles in cerebral ischemia-reperfusion rats based on ~1H-NMR]. ( Cao, DM; Guan, QX; Liu, YL; Wang, SM, 2020) |
| "Choline and creatine are commonly used as denominators for other metabolites in ischemic stroke spectroscopy, assuming that they do not change." | 7.74 | Choline and creatine are not reliable denominators for calculating metabolite ratios in acute ischemic stroke. ( Armitage, PA; Bastin, ME; Cvoro, V; Marshall, I; Muñoz Maniega, S; Wardlaw, JM, 2008) |
| "Phosphocreatine is a major cellular source of high energy phosphates, which is crucial to maintain cell viability under conditions of impaired metabolic states, such as decreased oxygen and energy availability (i." | 5.38 | FTIR imaging of brain tissue reveals crystalline creatine deposits are an ex vivo marker of localized ischemia during murine cerebral malaria: general implications for disease neurochemistry. ( Carter, EA; El-Assaad, F; Grau, GE; Hackett, MJ; Hunt, NH; Lay, PA; Lee, J; McQuillan, JA, 2012) |
| " We decided to administer it by intracerebroventricular infusion, to maximize its bioavailability to the brain." | 5.33 | Intracerebroventricular administration of creatine protects against damage by global cerebral ischemia in rat. ( Balestrino, M; Gandolfo, C; Izvarina, N; Korzhevskii, DE; Kostkin, VB; Lensman, M; Mourovets, VO; Otellin, VA; Perasso, L; Polenov, SA, 2006) |
| "Serum metabonomic profiles of the model of focal cerebral ischemia reperfusion is established with the suture-occluded method by Longa to study the effect of ginsenosides." | 3.96 | [Effect of ginsenosides on serous metabonomic profiles in cerebral ischemia-reperfusion rats based on ~1H-NMR]. ( Cao, DM; Guan, QX; Liu, YL; Wang, SM, 2020) |
| "Choline and creatine are commonly used as denominators for other metabolites in ischemic stroke spectroscopy, assuming that they do not change." | 3.74 | Choline and creatine are not reliable denominators for calculating metabolite ratios in acute ischemic stroke. ( Armitage, PA; Bastin, ME; Cvoro, V; Marshall, I; Muñoz Maniega, S; Wardlaw, JM, 2008) |
| " T2 weighted-imaging (T2WI) and 1H-magnetic resonance spectroscopy (1H-MRS) were performed, to study the changes of the imaging and the neuronal metabolites N-acetyl aspartate (NAA), creatine/phosphocreatine (Cr/PCr), choline (Cho) and lactose (Lac) in cerebrum following cerebral ischemia." | 3.72 | [The effects of Erigeron breviscapus preparation on the imaging and neuronal metabolites at the early time points after reperfusion following the ischemic cerebral injury in rats]. ( Fan, M; Li, LY; Liao, WJ; Liu, ML; Yang, WT; Yang, YH, 2003) |
| "The apparent diffusion coefficient (ADC) of choline-containing compounds (Cho), creatine and phosphocreatine (Cre), N-acetyl-aspartate (NAA), lactate, and water was measured in normal rat brain, and in the ischemic and contralateral region of rat brain approximately 3 and 24 h after induction of focal cerebral ischemia." | 3.69 | Diffusion of metabolites in normal and ischemic rat brain measured by localized 1H MRS. ( Dijkhuizen, RM; Nicolay, K; Tulleken, CA; van der Toorn, A, 1996) |
| " First, in patients with cerebral infarctions, increased concentrations of lactate were found in the majority of patients, and N-acetyl aspartate (NAA) was reduced to a significantly greater extent than choline (Cho) or creatine (Cre)." | 3.68 | Proton magnetic resonance spectroscopy of human brain: applications to normal white matter, chronic infarction, and MRI white matter signal hyperintensities. ( Calabrese, G; Deicken, R; Fein, G; Fisher, SN; Hetherington, HP; Sappey-Marinier, D; Van Dyke, C; Weiner, MW, 1992) |
| "Phosphocreatine (PCr) has been administered after human MI, where it proved to be safe and probably helpful." | 2.49 | Therapeutic use of creatine in brain or heart ischemia: available data and future perspectives. ( Balestrino, M; Gandolfo, C; Perasso, L; Ruggeri, P; Spallarossa, P, 2013) |
| "In this study, we used a global cerebral ischemia induced by four-vessel occlusion as an established animal model for ischemic stroke to investigate metabolic changes after 24 h reperfusion, when transitions occur due to the onset of delayed neuronal death." | 1.48 | NMR metabolomic study of blood plasma in ischemic and ischemically preconditioned rats: an increased level of ketone bodies and decreased content of glycolytic products 24 h after global cerebral ischemia. ( Baranovicova, E; Cierny, D; Grendar, M; Kalenska, D; Lehotsky, J; Tomascova, A, 2018) |
| "Phosphocreatine is a major cellular source of high energy phosphates, which is crucial to maintain cell viability under conditions of impaired metabolic states, such as decreased oxygen and energy availability (i." | 1.38 | FTIR imaging of brain tissue reveals crystalline creatine deposits are an ex vivo marker of localized ischemia during murine cerebral malaria: general implications for disease neurochemistry. ( Carter, EA; El-Assaad, F; Grau, GE; Hackett, MJ; Hunt, NH; Lay, PA; Lee, J; McQuillan, JA, 2012) |
| "We utilized a global cerebral ischemia model induced by arresting the heart with a combination of hypovolemia and intracardiac injections of a cold potassium chloride solution in order to study the potential therapeutic benefits of human mesenchymal stem cells (hMSCs) on global cerebral ischemia." | 1.36 | Therapeutic benefits of human mesenchymal stem cells derived from bone marrow after global cerebral ischemia. ( Hamada, H; Harada, K; Honmou, O; Houkin, K; Kocsis, JD; Liu, H; Miyata, K; Suzuki, J; Zheng, W, 2010) |
| "We used a mouse model of transient middle cerebral artery occlusion." | 1.35 | In vivo neuroprotection by a creatine-derived compound: phosphocreatine-Mg-complex acetate. ( Adriano, E; Balestrino, M; Burov, SV; Gandolfo, C; Perasso, L; Ruggeri, P, 2009) |
| " We decided to administer it by intracerebroventricular infusion, to maximize its bioavailability to the brain." | 1.33 | Intracerebroventricular administration of creatine protects against damage by global cerebral ischemia in rat. ( Balestrino, M; Gandolfo, C; Izvarina, N; Korzhevskii, DE; Kostkin, VB; Lensman, M; Mourovets, VO; Otellin, VA; Perasso, L; Polenov, SA, 2006) |
| "GbE could prevent and treat acute cerebral ischemia." | 1.32 | Effects of Ginkgo biloba extract on acute cerebral ischemia in rats analyzed by magnetic resonance spectroscopy. ( Li, YF; Peng, H; Sun, SG, 2003) |
| "Creatine was infused intraventricularly to 11 animals using an automatic Alzet osmotic minipump." | 1.32 | [Structural characteristics of astrocytes from the rat hippocampus in postischemia]. ( Balestrino, M; Grigor'ev, IP; Korzhevskiĭ, DE; Kostkin, VB; Lentsman, MV; Otellin, VA; Polenov, SA, 2004) |
| "Subcortical ischemic vascular dementia is associated with cortical hypometabolism and hypoperfusion, and this reduced cortical metabolism or blood flow can be detected with functional imaging such as positron emission tomography." | 1.31 | Subcortical ischemic vascular dementia: assessment with quantitative MR imaging and 1H MR spectroscopy. ( Amend, DL; Capizzano, AA; Chui, HC; Fein, G; Jagust, W; Maudsley, AA; Norman, D; Schuff, N; Segal, MR; Tanabe, JL; Weiner, MW, 2000) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (4.55) | 18.7374 |
| 1990's | 21 (31.82) | 18.2507 |
| 2000's | 23 (34.85) | 29.6817 |
| 2010's | 16 (24.24) | 24.3611 |
| 2020's | 3 (4.55) | 2.80 |
| Authors | Studies |
|---|---|
| Laredo, C | 1 |
| Rodríguez, A | 1 |
| Oleaga, L | 1 |
| Hernández-Pérez, M | 1 |
| Renú, A | 1 |
| Puig, J | 1 |
| Román, LS | 1 |
| Planas, AM | 1 |
| Urra, X | 1 |
| Chamorro, Á | 1 |
| Genovese, G | 1 |
| Diaz-Fernandez, B | 1 |
| Lejeune, FX | 1 |
| Ronen, I | 1 |
| Marjańska, M | 1 |
| Yahia-Cherif, L | 1 |
| Lehéricy, S | 1 |
| Branzoli, F | 1 |
| Rosso, C | 1 |
| Cao, DM | 1 |
| Guan, QX | 1 |
| Liu, YL | 1 |
| Wang, SM | 1 |
| Baranovicova, E | 1 |
| Grendar, M | 1 |
| Kalenska, D | 1 |
| Tomascova, A | 1 |
| Cierny, D | 1 |
| Lehotsky, J | 1 |
| Gasparovic, C | 1 |
| Prestopnik, J | 1 |
| Thompson, J | 1 |
| Taheri, S | 1 |
| Huisa, B | 1 |
| Schrader, R | 1 |
| Adair, JC | 1 |
| Rosenberg, GA | 2 |
| Guan, YM | 1 |
| Zhu, Y | 1 |
| Liu, XC | 1 |
| Huang, HL | 1 |
| Wang, ZW | 1 |
| Liu, B | 1 |
| Zhu, YZ | 1 |
| Wang, QS | 1 |
| Shemesh, N | 1 |
| Rosenberg, JT | 1 |
| Dumez, JN | 1 |
| Grant, SC | 1 |
| Frydman, L | 1 |
| Hackett, MJ | 2 |
| Britz, CJ | 1 |
| Paterson, PG | 1 |
| Nichol, H | 1 |
| Pickering, IJ | 1 |
| George, GN | 1 |
| Kolpakova, ME | 1 |
| Veselkina, OS | 2 |
| Vlasov, TD | 2 |
| Bivard, A | 1 |
| Yassi, N | 1 |
| Krishnamurthy, V | 1 |
| Lin, L | 1 |
| Levi, C | 1 |
| Spratt, NJ | 1 |
| Mittef, F | 1 |
| Davis, S | 1 |
| Parsons, M | 1 |
| Auriel, E | 1 |
| Kliper, E | 1 |
| Shenhar-Tsarfaty, S | 1 |
| Molad, J | 1 |
| Berliner, S | 1 |
| Shapira, I | 1 |
| Ben-Bashat, D | 1 |
| Shopin, L | 1 |
| Tene, O | 1 |
| Bornstein, NM | 1 |
| Ben Assayag, E | 1 |
| Jiménez-Xarrié, E | 1 |
| Davila, M | 1 |
| Candiota, AP | 1 |
| Delgado-Mederos, R | 1 |
| Ortega-Martorell, S | 1 |
| Julià-Sapé, M | 1 |
| Arús, C | 1 |
| Martí-Fàbregas, J | 1 |
| Muñoz Maniega, S | 1 |
| Cvoro, V | 1 |
| Armitage, PA | 2 |
| Marshall, I | 3 |
| Bastin, ME | 1 |
| Wardlaw, JM | 3 |
| Perasso, L | 4 |
| Adriano, E | 1 |
| Ruggeri, P | 2 |
| Burov, SV | 2 |
| Gandolfo, C | 3 |
| Balestrino, M | 5 |
| Zheng, W | 1 |
| Honmou, O | 1 |
| Miyata, K | 1 |
| Harada, K | 1 |
| Suzuki, J | 1 |
| Liu, H | 1 |
| Houkin, K | 2 |
| Hamada, H | 1 |
| Kocsis, JD | 1 |
| Karaszewski, B | 1 |
| Thomas, RG | 1 |
| Chappell, FM | 1 |
| Carpenter, TK | 1 |
| Lymer, GK | 1 |
| Dennis, MS | 1 |
| Chefu, SG | 1 |
| Baĭsa, AE | 1 |
| Leko, MV | 1 |
| Mullins, ME | 1 |
| Zheng, DD | 1 |
| Liu, ZH | 1 |
| Fang, J | 1 |
| Wang, XY | 1 |
| Zhang, J | 1 |
| Spallarossa, P | 1 |
| Lee, J | 1 |
| El-Assaad, F | 1 |
| McQuillan, JA | 1 |
| Carter, EA | 1 |
| Grau, GE | 1 |
| Hunt, NH | 1 |
| Lay, PA | 1 |
| Lensman, M | 2 |
| Parodi, M | 1 |
| Rebaudo, R | 1 |
| Melani, R | 1 |
| Polenov, S | 1 |
| Cupello, A | 1 |
| Macmillan, CS | 1 |
| Wild, JM | 1 |
| Andrews, PJ | 1 |
| Easton, VJ | 1 |
| Schwarcz, A | 1 |
| Natt, O | 1 |
| Watanabe, T | 1 |
| Boretius, S | 1 |
| Frahm, J | 3 |
| Michaelis, T | 2 |
| Peng, H | 1 |
| Li, YF | 1 |
| Sun, SG | 1 |
| Lei, H | 1 |
| Zhang, Y | 1 |
| Zhu, XH | 1 |
| Chen, W | 1 |
| Liao, WJ | 1 |
| Yang, YH | 1 |
| Fan, M | 1 |
| Yang, WT | 1 |
| Li, LY | 1 |
| Liu, ML | 1 |
| Zhu, S | 1 |
| Li, M | 1 |
| Figueroa, BE | 1 |
| Liu, A | 1 |
| Stavrovskaya, IG | 1 |
| Pasinelli, P | 1 |
| Beal, MF | 1 |
| Brown, RH | 1 |
| Kristal, BS | 1 |
| Ferrante, RJ | 1 |
| Friedlander, RM | 1 |
| Korzhevskiĭ, DE | 2 |
| Otellin, VA | 2 |
| Grigor'ev, IP | 1 |
| Kostkin, VB | 2 |
| Polenov, SA | 2 |
| Lentsman, MV | 1 |
| Marmarou, A | 1 |
| Signoretti, S | 1 |
| Fatouros, P | 1 |
| Aygok, GA | 1 |
| Bullock, R | 1 |
| Prass, K | 1 |
| Royl, G | 1 |
| Lindauer, U | 1 |
| Freyer, D | 1 |
| Megow, D | 1 |
| Dirnagl, U | 1 |
| Stöckler-Ipsiroglu, G | 1 |
| Wallimann, T | 1 |
| Priller, J | 1 |
| Mourovets, VO | 1 |
| Izvarina, N | 1 |
| Glodzik-Sobanska, L | 1 |
| Li, J | 1 |
| Mosconi, L | 1 |
| Slowik, A | 1 |
| Walecki, J | 1 |
| Szczudlik, A | 1 |
| Sobiecka, B | 1 |
| de Leon, MJ | 1 |
| Nitkunan, A | 1 |
| Charlton, RA | 1 |
| McIntyre, DJ | 1 |
| Barrick, TR | 1 |
| Howe, FA | 1 |
| Markus, HS | 1 |
| Whittingham, TS | 1 |
| Lust, WD | 1 |
| Passonneau, JV | 1 |
| Woznicki, DT | 1 |
| Walker, JB | 1 |
| Constans, JM | 2 |
| Meyerhoff, DJ | 2 |
| Gerson, J | 1 |
| MacKay, S | 2 |
| Norman, D | 3 |
| Fein, G | 4 |
| Weiner, MW | 6 |
| Wick, M | 2 |
| Nagatomo, Y | 1 |
| Prielmeier, F | 1 |
| van der Toorn, A | 2 |
| Verheul, HB | 1 |
| Berkelbach van der Sprenkel, JW | 1 |
| Tulleken, CA | 2 |
| Nicolay, K | 2 |
| Federico, F | 2 |
| Conte, C | 2 |
| Simone, IL | 1 |
| Giannini, P | 1 |
| Liguori, M | 1 |
| Picciola, E | 1 |
| Tortorella, C | 1 |
| Ferrari, E | 1 |
| Kamada, K | 1 |
| Hida, K | 1 |
| Matsuzawa, H | 1 |
| Iwasaki, Y | 1 |
| Abe, H | 1 |
| Nakada, T | 1 |
| van Zijl, PC | 1 |
| Moonen, CT | 1 |
| Bourgeois, D | 1 |
| Kozlowski, P | 1 |
| Lauriero, F | 1 |
| Rubini, G | 1 |
| Simone, I | 1 |
| Inchingolo, V | 1 |
| d'Addabbo, A | 1 |
| Dijkhuizen, RM | 1 |
| Higuchi, T | 2 |
| Graham, SH | 1 |
| Fernandez, EJ | 2 |
| Rooney, WD | 1 |
| Gaspary, HL | 1 |
| Maudsley, AA | 3 |
| Harada, M | 3 |
| Miyoshi, H | 1 |
| Ootsuka, H | 1 |
| Taoka, Y | 1 |
| Tanouchi, M | 1 |
| Nishitani, H | 2 |
| Sibbitt, WL | 1 |
| Haseler, LJ | 1 |
| Griffey, RR | 1 |
| Friedman, SD | 1 |
| Brooks, WM | 1 |
| Sengar, AR | 1 |
| Gupta, RK | 1 |
| Dhanuka, AK | 1 |
| Roy, R | 1 |
| Das, K | 1 |
| Fujimori, H | 1 |
| Nonaka, M | 1 |
| Yoshimine, T | 1 |
| Kohmura, E | 1 |
| Wakayama, A | 1 |
| Yamashita, T | 1 |
| Hayakawa, T | 1 |
| Toner, CC | 1 |
| Stamford, JA | 1 |
| Vahedi, K | 1 |
| Domigo, V | 1 |
| Amarenco, P | 1 |
| Bousser, MG | 1 |
| George, AE | 1 |
| Cha, S | 1 |
| Capizzano, AA | 1 |
| Schuff, N | 1 |
| Amend, DL | 1 |
| Tanabe, JL | 1 |
| Jagust, W | 1 |
| Chui, HC | 1 |
| Segal, MR | 1 |
| Kim, GE | 1 |
| Lee, JH | 1 |
| Cho, YP | 1 |
| Kim, ST | 1 |
| Son, BC | 1 |
| Park, CK | 1 |
| Choi, BG | 1 |
| Kim, EN | 1 |
| Choe, BY | 1 |
| Lee, KS | 1 |
| Kim, MC | 1 |
| Kang, JK | 1 |
| Uno, M | 2 |
| Nagahiro, S | 1 |
| Massieu, L | 1 |
| Del Río, P | 1 |
| Montiel, T | 1 |
| Hong, F | 1 |
| Hisaoka, S | 1 |
| Matsuda, T | 1 |
| Lebedev, VV | 1 |
| Iunovidov, IM | 1 |
| Smirnova, EL | 1 |
| Wang, Z | 1 |
| Bogdan, AR | 1 |
| Zimmerman, RA | 1 |
| Gusnard, DA | 1 |
| Leigh, JS | 1 |
| Ohene-Frempong, K | 1 |
| Gideon, P | 1 |
| Henriksen, O | 1 |
| Sappey-Marinier, D | 1 |
| Calabrese, G | 1 |
| Hetherington, HP | 1 |
| Fisher, SN | 1 |
| Deicken, R | 1 |
| Van Dyke, C | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| CHemical OptImization of Cerebral Embolectomy in Patients With Acute Stroke Treated With Mechanical Thrombectomy 2 (CHOICE 2 TRIAL)[NCT05797792] | Phase 3 | 440 participants (Anticipated) | Interventional | 2023-06-01 | Not yet recruiting | ||
| MRI for Early Identification of Underlying Pathology in Patients With Acute Intracerebral Hemorrhage[NCT01689402] | 60 participants (Actual) | Observational | 2012-04-30 | Completed | |||
| Libman-Sacks Endocarditis as a Cause of Neuropsychiatric Systemic Lupus Erythematosus[NCT00858884] | 68 participants (Actual) | Interventional | 2006-08-31 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
3 reviews available for creatine and Brain Ischemia
| Article | Year |
|---|---|
[Creatine in a metabolism of cell and its protective action at brain ischemia].
Topics: Blood-Brain Barrier; Brain Ischemia; Creatine; Energy Metabolism; Humans; Hypoxia; Membrane Transpor | 2013 |
Therapeutic use of creatine in brain or heart ischemia: available data and future perspectives.
Topics: Blood-Brain Barrier; Brain Ischemia; Cardiotonic Agents; Creatine; Female; Forecasting; Humans; In V | 2013 |
Role of creatine and phosphocreatine in neuronal protection from anoxic and ischemic damage.
Topics: Adenosine Triphosphate; Animals; Blood-Brain Barrier; Brain Ischemia; Creatine; Glucose; Hippocampus | 2002 |
2 trials available for creatine and Brain Ischemia
| Article | Year |
|---|---|
Adjunct Thrombolysis Enhances Brain Reperfusion following Successful Thrombectomy.
Topics: Aged; Aged, 80 and over; Brain; Brain Ischemia; Cerebral Infarction; Creatine; Endovascular Procedur | 2022 |
Mitochondrial injury measured by proton magnetic resonance spectroscopy in severe head trauma patients.
Topics: Adult; Aspartic Acid; Biomarkers; Brain; Brain Ischemia; Choline; Craniocerebral Trauma; Creatine; F | 2005 |
61 other studies available for creatine and Brain Ischemia
| Article | Year |
|---|---|
Longitudinal Monitoring of Microstructural Alterations in Cerebral Ischemia with in Vivo Diffusion-weighted MR Spectroscopy.
Topics: Brain Ischemia; Choline; Creatine; Female; Humans; Ischemic Stroke; Longitudinal Studies; Magnetic R | 2023 |
[Effect of ginsenosides on serous metabonomic profiles in cerebral ischemia-reperfusion rats based on ~1H-NMR].
Topics: 3-Hydroxybutyric Acid; Animals; Brain Ischemia; Creatine; Ginsenosides; Hemolymph; Metabolome; Phosp | 2020 |
NMR metabolomic study of blood plasma in ischemic and ischemically preconditioned rats: an increased level of ketone bodies and decreased content of glycolytic products 24 h after global cerebral ischemia.
Topics: Acetic Acid; Animals; Biomarkers; Blood Glucose; Brain Ischemia; Cerebrovascular Disorders; Creatine | 2018 |
1H-MR spectroscopy metabolite levels correlate with executive function in vascular cognitive impairment.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Aspartic Acid; Biomarkers; Brain Ischemia; Choline; Cogn | 2013 |
Effect of human umbilical cord blood mesenchymal stem cell transplantation on neuronal metabolites in ischemic rabbits.
Topics: Animals; Aspartic Acid; Brain; Brain Ischemia; Choline; Cord Blood Stem Cell Transplantation; Creati | 2014 |
Metabolic T1 dynamics and longitudinal relaxation enhancement in vivo at ultrahigh magnetic fields on ischemia.
Topics: Animals; Aspartic Acid; Brain Ischemia; Cerebral Angiography; Cerebrovascular Circulation; Choline; | 2014 |
In situ biospectroscopic investigation of rapid ischemic and postmortem induced biochemical alterations in the rat brain.
Topics: Animals; Brain Ischemia; Cerebellum; Creatine; Decapitation; Dissection; Disulfides; Freezing; Lacti | 2015 |
A comprehensive analysis of metabolic changes in the salvaged penumbra.
Topics: Adult; Aged; Aged, 80 and over; Brain Ischemia; Case-Control Studies; Creatine; Female; Glutamic Aci | 2016 |
Impaired renal function is associated with brain atrophy and poststroke cognitive decline.
Topics: Aged; Atrophy; Brain; Brain Ischemia; Cognitive Dysfunction; Creatine; Diffusion Tensor Imaging; Fem | 2016 |
Brain metabolic pattern analysis using a magnetic resonance spectra classification software in experimental stroke.
Topics: Animals; Brain; Brain Ischemia; Creatine; Image Processing, Computer-Assisted; Inositol; Lactic Acid | 2017 |
Choline and creatine are not reliable denominators for calculating metabolite ratios in acute ischemic stroke.
Topics: Acute Disease; Aged; Aged, 80 and over; Biomarkers; Brain; Brain Ischemia; Choline; Creatine; Down-R | 2008 |
In vivo neuroprotection by a creatine-derived compound: phosphocreatine-Mg-complex acetate.
Topics: Animals; Brain Infarction; Brain Ischemia; Creatine; Cytoprotection; Disease Models, Animal; Infarct | 2009 |
Therapeutic benefits of human mesenchymal stem cells derived from bone marrow after global cerebral ischemia.
Topics: Analysis of Variance; Animals; Bone Marrow Cells; Brain Ischemia; Brain-Derived Neurotrophic Factor; | 2010 |
Brain choline concentration. Early quantitative marker of ischemia and infarct expansion?
Topics: Aged; Aged, 80 and over; Brain; Brain Ischemia; Brain Mapping; Cerebral Infarction; Choline; Creatin | 2010 |
[Amides of creatine: perspectives of neuroprotection].
Topics: Amides; Animals; Brain Ischemia; Creatine; Female; gamma-Aminobutyric Acid; Glycine; Hemodynamics; I | 2011 |
Daydreaming about our metaphorical tool belt.
Topics: Aging; Aspartic Acid; Brain; Brain Ischemia; Choline; Creatine; Female; Humans; Male | 2012 |
The effect of age and cerebral ischemia on diffusion-weighted proton MR spectroscopy of the human brain.
Topics: Adult; Aging; Aspartic Acid; Brain; Brain Ischemia; Choline; Creatine; Female; Humans; Male; Reprodu | 2012 |
FTIR imaging of brain tissue reveals crystalline creatine deposits are an ex vivo marker of localized ischemia during murine cerebral malaria: general implications for disease neurochemistry.
Topics: Animals; Biomarkers; Brain; Brain Ischemia; Creatine; Malaria, Cerebral; Mice; Phosphocreatine; Spec | 2012 |
Traumatic brain injury and subarachnoid hemorrhage: in vivo occult pathology demonstrated by magnetic resonance spectroscopy may not be "ischaemic". A primary study and review of the literature.
Topics: Adolescent; Adult; Aspartic Acid; Brain; Brain Injuries; Brain Ischemia; Child; Choline; Creatine; C | 2002 |
Localized proton MRS of cerebral metabolite profiles in different mouse strains.
Topics: Animals; Aspartic Acid; Brain; Brain Ischemia; Choline; Creatine; Magnetic Resonance Spectroscopy; M | 2003 |
Effects of Ginkgo biloba extract on acute cerebral ischemia in rats analyzed by magnetic resonance spectroscopy.
Topics: Animals; Aspartic Acid; Brain Ischemia; Choline; Creatine; Drugs, Chinese Herbal; Ginkgo biloba; Hip | 2003 |
Changes in the proton T2 relaxation times of cerebral water and metabolites during forebrain ischemia in rat at 9.4 T.
Topics: Animals; Aspartic Acid; Brain Ischemia; Creatine; Linear Models; Magnetic Resonance Spectroscopy; Ma | 2003 |
[The effects of Erigeron breviscapus preparation on the imaging and neuronal metabolites at the early time points after reperfusion following the ischemic cerebral injury in rats].
Topics: Animals; Aspartic Acid; Asteraceae; Brain; Brain Ischemia; Choline; Creatine; Drugs, Chinese Herbal; | 2003 |
Prophylactic creatine administration mediates neuroprotection in cerebral ischemia in mice.
Topics: Adenosine Triphosphate; Administration, Oral; Animals; Apoptosis; Brain Ischemia; Caspase 3; Caspase | 2004 |
[Structural characteristics of astrocytes from the rat hippocampus in postischemia].
Topics: Animals; Astrocytes; Brain Ischemia; Creatine; Glial Fibrillary Acidic Protein; Hippocampus; Male; N | 2004 |
Improved reperfusion and neuroprotection by creatine in a mouse model of stroke.
Topics: Adenosine Triphosphate; Animals; Brain; Brain Ischemia; Cerebrovascular Circulation; Creatine; Disea | 2007 |
Intracerebroventricular administration of creatine protects against damage by global cerebral ischemia in rat.
Topics: Animals; Brain Ischemia; Cerebral Infarction; Creatine; Disease Models, Animal; Drug Administration | 2006 |
Prefrontal N-acetylaspartate and poststroke recovery: a longitudinal proton spectroscopy study.
Topics: Aged; Aged, 80 and over; Aspartic Acid; Brain Ischemia; Creatine; Female; Follow-Up Studies; Functio | 2007 |
Diffusion tensor imaging and MR spectroscopy in hypertension and presumed cerebral small vessel disease.
Topics: Aged; Aspartic Acid; Brain Diseases; Brain Ischemia; Case-Control Studies; Cerebrovascular Circulati | 2008 |
An in vitro model of ischemia: metabolic and electrical alterations in the hippocampal slice.
Topics: Adenosine Monophosphate; Adenosine Triphosphate; Animals; Brain Ischemia; Creatine; Cyclic AMP; Cycl | 1984 |
Utilization of cyclocreatine phosphate, and analogue of creatine phosphate, by mouse brain during ischemia and its sparing action on brain energy reserves.
Topics: Adenosine Triphosphate; Animals; Aspartic Acid; Brain; Brain Ischemia; Creatine; Energy Metabolism; | 1980 |
H-1 MR spectroscopic imaging of white matter signal hyperintensities: Alzheimer disease and ischemic vascular dementia.
Topics: Aged; Alzheimer Disease; Aspartic Acid; Brain; Brain Diseases; Brain Ischemia; Case-Control Studies; | 1995 |
Alteration of intracellular metabolite diffusion in rat brain in vivo during ischemia and reperfusion.
Topics: Animals; Aspartic Acid; Body Water; Brain; Brain Ischemia; Choline; Creatine; Diffusion; Inositol; I | 1995 |
Changes in metabolites and tissue water status after focal ischemia in cat brain assessed with localized proton MR spectroscopy.
Topics: Animals; Aspartic Acid; Body Water; Brain; Brain Ischemia; Cats; Creatine; Diffusion; Female; Lactat | 1994 |
Proton magnetic resonance spectroscopy in patients with ischemic stroke.
Topics: Adult; Aged; Aspartic Acid; Brain; Brain Ischemia; Case-Control Studies; Choline; Creatine; Female; | 1994 |
Localized proton spectroscopy of focal brain pathology in humans: significant effects of edema on spin-spin relaxation time.
Topics: Adult; Aged; Aspartic Acid; Astrocytoma; Brain; Brain Edema; Brain Ischemia; Brain Neoplasms; Cerebr | 1994 |
In situ changes in purine nucleotide and N-acetyl concentrations upon inducing global ischemia in cat brain.
Topics: Acetylation; Adenosine; Animals; Aspartic Acid; Brain Ischemia; Cats; Choline; Creatine; Female; gam | 1993 |
A highly sensitive lactate editing technique for surface coil spectroscopic imaging in vivo.
Topics: Animals; Aspartic Acid; Brain; Brain Ischemia; Choline; Creatine; Electron Spin Resonance Spectrosco | 1993 |
Regional gray and white matter metabolite differences in subjects with AD, with subcortical ischemic vascular dementia, and elderly controls with 1H magnetic resonance spectroscopic imaging.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Analysis of Variance; Aspartic Acid; Brain; Brain Ischem | 1996 |
99Tcm-HMPAO SPET and 1H-MRS (proton magnetic resonance spectroscopy) in patients with ischaemic cerebral infarction.
Topics: Adult; Aged; Aspartic Acid; Brain Ischemia; Cerebral Infarction; Cerebrovascular Circulation; Cholin | 1996 |
Diffusion of metabolites in normal and ischemic rat brain measured by localized 1H MRS.
Topics: Animals; Aspartic Acid; Brain; Brain Ischemia; Choline; Creatine; Diffusion; Lactic Acid; Magnetic R | 1996 |
Effects of severe global ischemia on N-acetylaspartate and other metabolites in the rat brain.
Topics: Alanine; Animals; Aspartic Acid; Brain; Brain Ischemia; Creatine; Lactic Acid; Magnetic Resonance Im | 1997 |
[Accuracy and clinical utility of quantitative proton magnetic resonance spectroscopy (MRS) on phantom and chronic cerebral ischemia].
Topics: Aspartic Acid; Brain; Brain Ischemia; Chronic Disease; Creatine; Humans; Magnetic Resonance Spectros | 1997 |
Neurometabolism of active neuropsychiatric lupus determined with proton MR spectroscopy.
Topics: Adult; Aspartic Acid; Brain; Brain Damage, Chronic; Brain Ischemia; Brain Mapping; Choline; Creatine | 1997 |
MR imaging, MR angiography, and MR spectroscopy of the brain in eclampsia.
Topics: Adolescent; Adult; Aspartic Acid; Brain; Brain Edema; Brain Ischemia; Cerebral Arteries; Choline; Cr | 1997 |
Proton T2 relaxation of cerebral metabolites during transient global ischemia in rat brain.
Topics: Animals; Aspartic Acid; Brain; Brain Ischemia; Choline; Creatine; Image Processing, Computer-Assiste | 1998 |
Changes in brain organic osmolytes in experimental cerebral ischemia.
Topics: Alanine; Amino Acids; Animals; Aspartic Acid; Brain Chemistry; Brain Ischemia; Creatine; Disease Mod | 1998 |
Effects of metabolic alterations on dopamine release in an in vitro model of neostriatal ischaemia.
Topics: Animals; Brain Ischemia; Creatine; Dopamine; Electrophysiology; Hypoxia; In Vitro Techniques; Male; | 1999 |
Ischaemic stroke in a sportsman who consumed MaHuang extract and creatine monohydrate for body building.
Topics: Adult; Brain Ischemia; Creatine; Ephedra sinica; Ephedrine; Humans; Male; Plant Preparations; Stroke | 2000 |
Applying functional MR imaging to brain-behavioral research: can we do better than simple clinical measures?
Topics: Aspartic Acid; Brain; Brain Ischemia; Creatine; Dementia, Vascular; Humans; Magnetic Resonance Imagi | 2000 |
Subcortical ischemic vascular dementia: assessment with quantitative MR imaging and 1H MR spectroscopy.
Topics: Aged; Aspartic Acid; Brain Ischemia; Creatine; Dementia, Vascular; Female; Humans; Magnetic Resonanc | 2000 |
Metabolic changes in the ischemic penumbra after carotid endarterectomy in stroke patients by localized in vivo proton magnetic resonance spectroscopy (1H-MRS).
Topics: Aged; Aspartic Acid; Brain Ischemia; Carotid Stenosis; Cerebral Infarction; Choline; Creatine; Endar | 2001 |
Metabolic changes in pericontusional oedematous areas in mild head injury evaluated by 1H MRS.
Topics: Adolescent; Adult; Aged; Aspartic Acid; Brain; Brain Concussion; Brain Edema; Brain Ischemia; Creati | 2000 |
Quantitative evaluation of cerebral metabolites and cerebral blood flow in patients with carotid stenosis.
Topics: Adult; Aged; Aging; Aspartic Acid; Basal Ganglia; Brain Ischemia; Carotid Stenosis; Cerebral Cortex; | 2001 |
Neurotoxicity of glutamate uptake inhibition in vivo: correlation with succinate dehydrogenase activity and prevention by energy substrates.
Topics: 3-Hydroxybutyric Acid; Acetoacetates; Amino Acid Transport System X-AG; Animals; Brain Ischemia; Con | 2001 |
Diffusion-weighted in vivo localized proton MR spectroscopy of human cerebral ischemia and tumor.
Topics: Adult; Aspartic Acid; Brain Ischemia; Brain Neoplasms; Cerebral Infarction; Creatine; Diffusion; Fem | 2002 |
[Functional state of the kidneys in patients with acute cerebrovascular disorders].
Topics: Acute Disease; Adult; Aged; Blood Pressure; Brain Ischemia; Cerebral Hemorrhage; Creatine; Creatinin | 1978 |
Investigation of stroke in sickle cell disease by 1H nuclear magnetic resonance spectroscopy.
Topics: Adolescent; Adult; Anemia, Sickle Cell; Aspartic Acid; Atrophy; Brain; Brain Ischemia; Cerebral Infa | 1992 |
1H spectroscopic imaging of rat brain at 7 tesla.
Topics: Amino Acids; Animals; Aspartic Acid; Brain; Brain Ischemia; Choline; Creatine; Glutamates; Glutamic | 1992 |
In vivo relaxation of N-acetyl-aspartate, creatine plus phosphocreatine, and choline containing compounds during the course of brain infarction: a proton MRS study.
Topics: Adult; Aged; Aged, 80 and over; Aspartic Acid; Brain Ischemia; Choline; Creatine; Humans; Magnetic R | 1992 |
Proton magnetic resonance spectroscopy of human brain: applications to normal white matter, chronic infarction, and MRI white matter signal hyperintensities.
Topics: Aged; Aged, 80 and over; Aspartic Acid; Brain; Brain Chemistry; Brain Ischemia; Cerebral Infarction; | 1992 |