Page last updated: 2024-10-17

creatine and Anoxia-Ischemia, Brain

creatine has been researched along with Anoxia-Ischemia, Brain in 30 studies

Research Excerpts

ExcerptRelevanceReference
"While the use of creatine in human pregnancy is yet to be fully evaluated, its long-term use in healthy adults appears to be safe, and its well documented neuroprotective properties have recently been extended by demonstrations that creatine improves cognitive function in normal and elderly people, and motor skills in sleep-deprived subjects."8.90Creatine supplementation during pregnancy: summary of experimental studies suggesting a treatment to improve fetal and neonatal morbidity and reduce mortality in high-risk human pregnancy. ( Dickinson, H; Ellery, S; Ireland, Z; LaRosa, D; Snow, R; Walker, DW, 2014)
" In this review we discuss the prospect of using creatine as a dietary supplement during pregnancy and nutritional intervention that can significantly decrease the risk of brain damage in the event of severe oxygen deprivation at birth."4.93Dietary interventions designed to protect the perinatal brain from hypoxic-ischemic encephalopathy--Creatine prophylaxis and the need for multi-organ protection. ( Dickinson, H; Ellery, SJ; McKenzie, M; Walker, DW, 2016)
"While the use of creatine in human pregnancy is yet to be fully evaluated, its long-term use in healthy adults appears to be safe, and its well documented neuroprotective properties have recently been extended by demonstrations that creatine improves cognitive function in normal and elderly people, and motor skills in sleep-deprived subjects."4.90Creatine supplementation during pregnancy: summary of experimental studies suggesting a treatment to improve fetal and neonatal morbidity and reduce mortality in high-risk human pregnancy. ( Dickinson, H; Ellery, S; Ireland, Z; LaRosa, D; Snow, R; Walker, DW, 2014)
"We hypothesized that creatine (Cr) supplementation would preserve energy metabolism and thus ameliorate the energy failure and the extent of brain edema seen after severe but transient cerebral hypoxia-ischemia (HI) in the neonatal rat model."3.71Neuroprotection of creatine supplementation in neonatal rats with transient cerebral hypoxia-ischemia. ( Adcock, KH; Loenneker, T; Martin, E; Nedelcu, J; Wagner, BP; Wallimann, T, 2002)
"Creatine is a promising neuroprotective intervention for HIE."2.72Assessing Creatine Supplementation for Neuroprotection against Perinatal Hypoxic-Ischaemic Encephalopathy: A Systematic Review of Perinatal and Adult Pre-Clinical Studies. ( Ellery, SJ; Galinsky, R; Kelly, SB; Snow, RJ; Tran, NT; Walker, DW, 2021)
"Creatine (3 mM) was applied to tissue slices of the study groups 2 hours before the insult."1.32Creatine protects the immature brain from hypoxic-ischemic injury. ( Berger, R; Jensen, A; Middelanis, J; Mies, G; Vaihinger, HM; Wilken, B, 2004)

Research

Studies (30)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's11 (36.67)29.6817
2010's16 (53.33)24.3611
2020's3 (10.00)2.80

Authors

AuthorsStudies
Barta, H2
Jermendy, A2
Kovacs, L1
Schiever, N1
Rudas, G2
Szabo, M2
Tran, NT1
Kelly, SB1
Snow, RJ1
Walker, DW3
Ellery, SJ2
Galinsky, R1
Lee, JW1
Sreepada, LP1
Bevers, MB1
Li, K1
Scirica, BM1
Santana da Silva, D1
Henderson, GV1
Bay, C1
Lin, AP1
Lopez-Marin, L1
Crespo-Eguilaz, N1
Dominguez, PD1
Vaquero, M1
Narbona, J1
Shibasaki, J1
Aida, N1
Morisaki, N1
Tomiyasu, M1
Nishi, Y1
Toyoshima, K1
Kolossvary, M1
Kozak, LR1
Lakatos, A1
Meder, U1
Seo, H1
Lim, KH1
Choi, JH1
Jeong, SM1
Dickinson, H2
Ellery, S1
Ireland, Z1
LaRosa, D1
Snow, R1
Robertson, NJ2
Thayyil, S1
Cady, EB2
Raivich, G1
Iqbal, S3
Ali, M3
Iqbal, F4
Allah Yar, R1
Akbar, A2
Xu, S1
Waddell, J1
Zhu, W2
Shi, D1
Marshall, AD1
McKenna, MC1
Gullapalli, RP1
McKenzie, M1
Munkeby, BH1
De Lange, C1
Emblem, KE1
Bjørnerud, A1
Kro, GA1
Andresen, J1
Winther-Larssen, EH1
Løberg, EM1
Hald, JK1
Zhong, W1
Qi, J1
Yin, P1
Wang, C1
Chang, L1
Horecký, J1
Gvozdjáková, A1
Kucharská, J1
Obrenovich, ME1
Palacios, HH1
Li, Y1
Vančová, O1
Aliev, G1
Park, HK1
Seol, IJ1
Kim, KS1
Jian, H1
Yi-Fang, W1
Qi, L1
Xiao-Song, H1
Gui-Yun, Z1
Adcock, KH1
Nedelcu, J1
Loenneker, T1
Martin, E1
Wallimann, T1
Wagner, BP1
Berger, R1
Middelanis, J1
Vaihinger, HM1
Mies, G1
Wilken, B1
Jensen, A1
He, SR1
Liu, R1
Cai, M1
Cai, Q1
Li, GF1
Xiao, JQ1
Lin, YX1
Huang, RY1
Huang, JY1
Wartenberg, KE1
Patsalides, A1
Yepes, MS1
Vannucci, RC1
Towfighi, J1
Vannucci, SJ1
da Silva, LF1
Höefel Filho, JR1
Anés, M1
Nunes, ML1
Cheong, JL1
Penrice, J1
Wyatt, JS1
Cox, IJ1
Pundik, S1
Robinson, S1
Lust, WD1
Zechel, J1
Buczek, M1
Selman, WR1
Gwak, M1
Park, P1
Kim, K1
Lim, K1
Jeong, S1
Baek, C1
Lee, J1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Optimising the Duration of Cooling Therapy in Mild Neonatal Encephalopathy[NCT03409770]140 participants (Anticipated)Interventional2019-10-10Active, not recruiting
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

5 reviews available for creatine and Anoxia-Ischemia, Brain

ArticleYear
Assessing Creatine Supplementation for Neuroprotection against Perinatal Hypoxic-Ischaemic Encephalopathy: A Systematic Review of Perinatal and Adult Pre-Clinical Studies.
    Cells, 2021, 10-27, Volume: 10, Issue:11

    Topics: Aging; Animals; Creatine; Dietary Supplements; Female; Hypoxia-Ischemia, Brain; Male; Neuroprotectio

2021
[Metabolic approach in epileptic encephalopathies in infants].
    Revista de neurologia, 2017, May-17, Volume: 64, Issue:s03

    Topics: Age of Onset; Biotin; Brain Diseases, Metabolic; Brain Diseases, Metabolic, Inborn; Child, Preschool

2017
Creatine supplementation during pregnancy: summary of experimental studies suggesting a treatment to improve fetal and neonatal morbidity and reduce mortality in high-risk human pregnancy.
    BMC pregnancy and childbirth, 2014, Apr-27, Volume: 14

    Topics: Creatine; Dietary Supplements; Female; Fetal Hypoxia; Humans; Hypoxia-Ischemia, Brain; Infant, Newbo

2014
Magnetic resonance spectroscopy biomarkers in term perinatal asphyxial encephalopathy: from neuropathological correlates to future clinical applications.
    Current pediatric reviews, 2014, Volume: 10, Issue:1

    Topics: Animals; Animals, Newborn; Aspartic Acid; Asphyxia Neonatorum; Biomarkers; Choline; Creatine; Diseas

2014
Dietary interventions designed to protect the perinatal brain from hypoxic-ischemic encephalopathy--Creatine prophylaxis and the need for multi-organ protection.
    Neurochemistry international, 2016, Volume: 95

    Topics: Animals; Asphyxia Neonatorum; Brain; Creatine; Dietary Supplements; Female; Humans; Hypoxia-Ischemia

2016

Trials

2 trials available for creatine and Anoxia-Ischemia, Brain

ArticleYear
Proton magnetic resonance spectroscopy in neonates with hypoxic-ischemic injury and its prognostic value.
    Translational research : the journal of laboratory and clinical medicine, 2008, Volume: 152, Issue:5

    Topics: Asphyxia Neonatorum; Basal Ganglia; Choline; Creatine; Female; Follow-Up Studies; Glutamic Acid; Glu

2008
Prognostic value of 1H-MRS in neonatal encephalopathy.
    Pediatric neurology, 2006, Volume: 34, Issue:5

    Topics: Apgar Score; Aspartic Acid; Asphyxia Neonatorum; Basal Ganglia; Choline; Creatine; Creatinine; Femal

2006

Other Studies

23 other studies available for creatine and Anoxia-Ischemia, Brain

ArticleYear
Predictive performance and metabolite dynamics of proton MR spectroscopy in neonatal hypoxic-ischemic encephalopathy.
    Pediatric research, 2022, Volume: 91, Issue:3

    Topics: Aspartic Acid; Choline; Creatine; Humans; Hypoxia-Ischemia, Brain; Infant, Newborn; Inositol; Proton

2022
Magnetic Resonance Spectroscopy of Hypoxic-Ischemic Encephalopathy After Cardiac Arrest.
    Neurology, 2022, 03-22, Volume: 98, Issue:12

    Topics: Aspartic Acid; Brain; Choline; Creatine; Heart Arrest; Humans; Hypoxia-Ischemia, Brain; Magnetic Res

2022
[Developmental amnesia and early brain damage: neuropsychology and neuroimaging].
    Revista de neurologia, 2018, Mar-01, Volume: 66, Issue:S01

    Topics: Adolescent; Amnesia; Aspartic Acid; Atrophy; Cerebral Palsy; Child; Choline; Creatine; Female; Fetal

2018
Changes in Brain Metabolite Concentrations after Neonatal Hypoxic-ischemic Encephalopathy.
    Radiology, 2018, Volume: 288, Issue:3

    Topics: Aspartic Acid; Creatine; Female; Glutamic Acid; Glutamine; Gray Matter; Humans; Hypoxia-Ischemia, Br

2018
Prognostic value of early, conventional proton magnetic resonance spectroscopy in cooled asphyxiated infants.
    BMC pediatrics, 2018, 09-15, Volume: 18, Issue:1

    Topics: Aspartic Acid; Brain; Creatine; Epilepsy; Female; Hearing Loss; Hospital Mortality; Humans; Hypother

2018
Similar neuroprotective effects of ischemic and hypoxic preconditioning on hypoxia-ischemia in the neonatal rat: a proton MRS study.
    International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience, 2013, Volume: 31, Issue:7

    Topics: Analysis of Variance; Animals; Animals, Newborn; Aspartic Acid; Brain; Creatine; Hypoxia-Ischemia, B

2013
Long term creatine monohydrate supplementation, following neonatal hypoxic ischemic insult, improves neuromuscular coordination and spatial learning in male albino mouse.
    Brain research, 2015, Apr-07, Volume: 1603

    Topics: Animals; Body Weight; Carotid Artery Diseases; Creatine; Disease Models, Animal; Hypoxia-Ischemia, B

2015
Creatine monohydrate supplementation for 10 weeks mediates neuroprotection and improves learning/memory following neonatal hypoxia ischemia encephalopathy in female albino mice.
    Brain research, 2015, Jan-21, Volume: 1595

    Topics: Analysis of Variance; Animals; Animals, Newborn; Creatine; Disease Models, Animal; Dose-Response Rel

2015
In vivo longitudinal proton magnetic resonance spectroscopy on neonatal hypoxic-ischemic rat brain injury: Neuroprotective effects of acetyl-L-carnitine.
    Magnetic resonance in medicine, 2015, Volume: 74, Issue:6

    Topics: Acetylcarnitine; Animals; Creatine; Drug Monitoring; Female; Humans; Hypoxia-Ischemia, Brain; Infant

2015
Effects of dietary creatine supplementation for 8 weeks on neuromuscular coordination and learning in male albino mouse following neonatal hypoxic ischemic insult.
    Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology, 2015, Volume: 36, Issue:5

    Topics: Animals; Animals, Newborn; Creatine; Dietary Supplements; Exploratory Behavior; Hypoxia-Ischemia, Br

2015
Effect of creatine monohydrate supplementation on relative serum level of IL-6 and IL-18 following neonatal hypoxia ischemia in male albino mouse.
    Pakistan journal of pharmaceutical sciences, 2015, Volume: 28, Issue:6

    Topics: Animals; Animals, Newborn; Asphyxia Neonatorum; Biomarkers; Creatine; Dietary Supplements; Disease M

2015
A piglet model for detection of hypoxic-ischemic brain injury with magnetic resonance imaging.
    Acta radiologica (Stockholm, Sweden : 1987), 2008, Volume: 49, Issue:9

    Topics: Animals; Animals, Newborn; Aspartic Acid; Basal Ganglia; Brain; Brain Chemistry; Choline; Creatine;

2008
Effects of coenzyme Q and creatine supplementation on brain energy metabolism in rats exposed to chronic cerebral hypoperfusion.
    Current Alzheimer research, 2011, Volume: 8, Issue:8

    Topics: Animals; Cerebral Cortex; Chronic Disease; Citrates; Creatine; Dietary Supplements; Disease Models,

2011
Protective effect of hypoxic preconditioning on hypoxic-ischemic injured newborn rats.
    Journal of Korean medical science, 2011, Volume: 26, Issue:11

    Topics: Animals; Animals, Newborn; Apoptosis; Aspartic Acid; Brain; Carotid Arteries; Creatine; Hypoxia-Isch

2011
Cerebral blood flow and metabolic changes in hippocampal regions of a modified rat model with chronic cerebral hypoperfusion.
    Acta neurologica Belgica, 2013, Volume: 113, Issue:3

    Topics: Animals; Aspartic Acid; Cerebrovascular Circulation; Creatine; Disease Models, Animal; Hippocampus;

2013
Neuroprotection of creatine supplementation in neonatal rats with transient cerebral hypoxia-ischemia.
    Developmental neuroscience, 2002, Volume: 24, Issue:5

    Topics: Animals; Animals, Newborn; Brain Edema; Creatine; Hypoxia-Ischemia, Brain; Magnetic Resonance Imagin

2002
Creatine protects the immature brain from hypoxic-ischemic injury.
    Journal of the Society for Gynecologic Investigation, 2004, Volume: 11, Issue:1

    Topics: Adenosine Triphosphate; Animals; Animals, Newborn; Brain; Creatine; Disease Models, Animal; Gestatio

2004
[Measurement of urinary lactate: creatine ratio for early identification of newborn infants at risk for the hypoxic-ischemic encephalopathy].
    Zhonghua er ke za zhi = Chinese journal of pediatrics, 2003, Volume: 41, Issue:4

    Topics: Case-Control Studies; Creatine; Female; Humans; Hypoxia-Ischemia, Brain; Infant, Newborn; Lactic Aci

2003
Is magnetic resonance spectroscopy superior to conventional diagnostic tools in hypoxic-ischemic encephalopathy?
    Journal of neuroimaging : official journal of the American Society of Neuroimaging, 2004, Volume: 14, Issue:2

    Topics: Aspartic Acid; Brain; Brain Death; Cell Death; Choline; Coma; Creatine; Diffusion Magnetic Resonance

2004
Secondary energy failure after cerebral hypoxia-ischemia in the immature rat.
    Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 2004, Volume: 24, Issue:10

    Topics: Adenosine Triphosphate; Age Factors; Animals; Biomarkers; Brain; Creatine; Energy Metabolism; Female

2004
Proton MR spectroscopy in neonates with perinatal cerebral hypoxic-ischemic injury: metabolite peak-area ratios, relaxation times, and absolute concentrations.
    AJNR. American journal of neuroradiology, 2006, Volume: 27, Issue:7

    Topics: Aspartic Acid; Birth Injuries; Body Water; Brain; Brain Chemistry; Child Development; Choline; Creat

2006
Regional metabolic status of the E-18 rat fetal brain following transient hypoxia/ischemia.
    Metabolic brain disease, 2006, Volume: 21, Issue:4

    Topics: Adenosine Triphosphate; Animals; Brain; Creatine; Disease Models, Animal; Female; Fetal Hypoxia; Glu

2006
The effects of dantrolene on hypoxic-ischemic injury in the neonatal rat brain.
    Anesthesia and analgesia, 2008, Volume: 106, Issue:1

    Topics: Animals; Animals, Newborn; Apoptosis; Aspartic Acid; Brain; Carotid Artery, Common; Creatine; Dantro

2008