creatine and Anemia studies

Anemia: A reduction in the number of circulating ERYTHROCYTES or in the quantity of HEMOGLOBIN.

Research Excerpts

Excerpt	Relevance	Reference
"In bleeding induced anemia of rabbits an increase of creatine in the red cells occurred, which in some cases amounted to more than 5-times the normal concentration."	7.65	Creatine during bleeding anemia of rabbits. ( Dumdey, E; Rapoport, S; Syllm-Rapoport, I, 1977)
"No creatine phosphate was found in either erythrocytes or reticulocytes."	5.26	[Creatine content in erythrocytes and blood plasma of chickens before and following stimulation of erythropoiesis by anemia]. ( Daniel, A; Dumdey, E; Syllm-Rapoport, I, 1980)
"Hemolytic or blood loss anemia was induce in six ponies and red blood cell concentrations of creatine, glucose-6-phosphate dehydrogenase (G-6-PD), lactate dehydrogenase (LDH), and aspartate transaminase (AST) were measured during the ensuing regenerative period."	3.66	Biochemical changes in equine erythrocytes during experimental regenerative anemia. ( Shull, RM, 1981)
"In bleeding induced anemia of rabbits an increase of creatine in the red cells occurred, which in some cases amounted to more than 5-times the normal concentration."	3.65	Creatine during bleeding anemia of rabbits. ( Dumdey, E; Rapoport, S; Syllm-Rapoport, I, 1977)
" Extended dosing of ESP has potential advantages for the patient and may also improve resource utilization."	2.43	Practical approach to the diagnosis and treatment of anemia associated with CKD in elderly. ( Agarwal, AK, 2006)
"The newly developed erythropoiesis agent darbepoetin alpha (DA) allows for once-monthly dosing in the treatment of anemia in patients on dialysis."	1.37	Testing a single monthly dose of darbepoetin alpha to maintain hemoglobin levels in continuous ambulatory peritoneal dialysis patients. ( Inoue, T; Kikuta, T; Sato, T; Suzuki, H; Tsuda, M; Uchida, K; Watanabe, Y, 2011)
" Therefore, a dose level of at least 28 kBq/kg may be a safe starting dose in humans."	1.32	Pharmacokinetics, dosimetry, and toxicity of the targetable atomic generator, 225Ac-HuM195, in nonhuman primates. ( Cheung, NK; Kramer, K; McDevitt, MR; Miederer, M; Scheinberg, DA; Sgouros, G, 2004)
" In the present report the first 9 weeks shall be presented in which all patients received an identical dosage of rh-EPO per kg body weight."	1.28	Evaluation of indicators of erythropoiesis stimulated by recombinant human erythropoietin in renal anemia. ( Daniel, A; Gross, J; Lun, A; Schmidt, G; Stamminger, G; Syllm-Rapoport, I; Zoellner, K, 1990)
"No creatine phosphate was found in either erythrocytes or reticulocytes."	1.26	[Creatine content in erythrocytes and blood plasma of chickens before and following stimulation of erythropoiesis by anemia]. ( Daniel, A; Dumdey, E; Syllm-Rapoport, I, 1980)

Timeframe	Studies, this research(%)	All Research%
pre-1990	26 (59.09)	18.7374
1990's	5 (11.36)	18.2507
2000's	8 (18.18)	29.6817
2010's	2 (4.55)	24.3611
2020's	3 (6.82)	2.80

Authors	Studies
Hasegawa, S	2
Nakamura, S	2
Sugiura, T	3
Tsuka, Y	2
Takahashi, N	3
Matsumura, K	3
Okumiya, T	3
Baden, M	2
Shiojima, I	3
Hayashi, O	1
Kikuchi, S	2
Yamamoto, Y	1
Fujii, K	1
Otagaki, M	1
Chase, HS	1
Hirsch, JS	1
Mohan, S	1
Rao, MK	1
Radhakrishnan, J	1
Esteva, S	1
Panisello, P	1
Casas, M	1
Torrella, JR	1
Pagés, T	1
Viscor, G	1
Gheith, O	1
Wafa, E	1
Hassan, N	1
Mostafa, A	1
Sheashaa, HA	1
Mahmoud, K	1
Shokeir, A	1
Ghoneim, MA	1
Kawada, N	1
Moriyama, T	1
Ichimaru, N	1
Imamura, R	1
Matsui, I	1
Takabatake, Y	1
Nagasawa, Y	1
Isaka, Y	1
Kojima, Y	1
Kokado, Y	1
Rakugi, H	1
Imai, E	1
Takahara, S	1
Suzuki, H	1
Inoue, T	1
Watanabe, Y	1
Kikuta, T	1
Sato, T	1
Tsuda, M	1
Uchida, K	1
Nakatan, T	1
Takemoto, Y	2
Tsuchida, AK	1
PIOTROWSKI, Z	1
Dinning, JS	1
Majaj, AS	1
Azzam, SA	1
Darby, WJ	1
Shunk, CH	1
Folkers, K	2
PRASAD, AS	1
SANDSTEAD, HH	1
SCHULERT, AR	1
EL-ROOBY, AS	1
JUNGNER, G	1
JUNGER, I	1
HERTZ, H	1
KRISTENSEN, HP	1
HOFF-JORGENSEN, E	1
KURTIDES, ES	1
RAMBACH, WA	1
ALT, HL	1
DELGRECO, F	1
MAHER, JF	1
FREEMAN, RB	1
SCHREINER, GE	2
BOCK, HE	1
WALLER, HD	1
KAUFMANN, W	1
LOEHR, GW	1
Miederer, M	1
McDevitt, MR	1
Sgouros, G	1
Kramer, K	1
Cheung, NK	1
Scheinberg, DA	1
Agarwal, AK	1
Go, I	1
Tsuchida, K	1
Sugimura, K	1
Nakatani, T	1
Zellner, DC	1
Iacono, JM	1
Wu, MJ	1
Feldman, BF	1
Zinkl, JG	1
Jain, NC	1
Syllm-Rapoport, I	3
Daniel, A	2
Dumdey, E	2
Shull, RM	1
Qu, N	1
Wen, JK	1
Li, E	1
Field, ML	1
Clark, JF	1
Henderson, C	1
Seymour, AM	1
Radda, GK	1
Umar, IA	1
Wuro-Chekke, AU	1
Gidado, A	1
Igbokwe, IO	1
Combet, S	1
Ferrier, ML	1
Landschoot, MV	1
Stoenoiu, M	1
Moulin, P	1
Miyata, T	1
Lameire, N	1
Devuyst, O	1
Rapoport, S	1
Ohno, Y	1
Rege, AB	1
Fisher, JW	1
Barona, J	1
Jóhannson, H	1
Siesjö, BK	1
Rotellar, C	1
Mazzoni, MJ	1
Mosher, WF	1
Aminrazavi, M	1
Bauer, A	1
Rakowski, TA	1
Winchester, JF	1
Schmidt, G	1
Stamminger, G	1
Gross, J	1
Lun, A	1
Zoellner, K	1
Rejman, AS	1
Grimes, AJ	1
Cotes, PM	1
Mansell, MA	1
Joekes, AM	1
Smith, EK	1
Welt, LG	1
Parisi, R	1
Astrup, J	1
Rörth, M	1
Farley, TM	1
Scholler, J	1
Smith, JL	1
Fitch, CD	1
Biron, PE	1
Howard, J	1
Valeri, CR	3
Kopriva, CJ	1
Fortier, NL	1
Opalinski, A	1
Beutler, E	1
Krupa, B	1

Trial			Phase	Enrollment	Study Type	Start Date	Status
A Cohort Study of Conversion From Aranesp® to NESP® for the Treatment of Anemia in Dialysis Patients[NCT02439697]				50 participants (Actual)	Interventional	2015-11-30	Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Article	Year
Negative effects of anemia on quality of life and its improvement by complete correction of anemia by administration of recombinant human erythropoietin in posttransplant patients. Clinical and experimental nephrology, 2009, Volume: 13, Issue:4 Topics: Adult; Anemia; Biomarkers; Creatine; Erythropoietin; Female; Glomerular Filtration Rate; Hematinics;	2009
The effect of ultrapure dialysate on improving renal anemia. Osaka city medical journal, 2007, Volume: 53, Issue:1 Topics: Aged; Anemia; C-Reactive Protein; Creatine; Dialysis Solutions; Dose-Response Relationship, Drug; Er	2007

Article	Year
Evaluation of recombinant human erythropoietin responsiveness by measuring erythrocyte creatine content in haemodialysis patients. BMC nephrology, 2021, 12-12, Volume: 22, Issue:1 Topics: Aged; Aged, 80 and over; Anemia; Creatine; Erythrocytes; Erythropoietin; Female; Humans; Male; Middl	2021
Diagnostic accuracy and clinical usefulness of erythrocyte creatine content to predict the improvement of anaemia in patients receiving maintenance haemodialysis. BMC nephrology, 2023, 01-03, Volume: 24, Issue:1 Topics: Anemia; Creatine; Erythrocytes; Erythropoietin; Hematinics; Hemoglobins; Humans; Renal Dialysis; Sod	2023
Shortened red blood cell age in patients with end-stage renal disease who were receiving haemodialysis: a cross-sectional study. BMC nephrology, 2020, 09-29, Volume: 21, Issue:1 Topics: Aged; Anemia; Creatine; Cross-Sectional Studies; Erythrocytes; Female; Humans; Kidney Failure, Chron	2020
Presence of early CKD-related metabolic complications predict progression of stage 3 CKD: a case-controlled study. BMC nephrology, 2014, Nov-27, Volume: 15 Topics: Acidosis; Aged; Aged, 80 and over; Anemia; Bicarbonates; Calcium; Case-Control Studies; Creatine; Di	2014
Morphofunctional responses to anaemia in rat skeletal muscle. Journal of anatomy, 2008, Volume: 212, Issue:6 Topics: Adenosine Triphosphate; Anemia; Animals; Capillaries; Creatine; Histocytochemistry; Hypoxia; Lactic	2008
Does posttransplant anemia at 6 months affect long-term outcome of live-donor kidney transplantation? A single-center experience. Clinical and experimental nephrology, 2009, Volume: 13, Issue:4 Topics: Adolescent; Adult; Anemia; Biomarkers; Creatine; Female; Graft Rejection; Graft Survival; Hemoglobin	2009
Testing a single monthly dose of darbepoetin alpha to maintain hemoglobin levels in continuous ambulatory peritoneal dialysis patients. Advances in peritoneal dialysis. Conference on Peritoneal Dialysis, 2011, Volume: 27 Topics: Anemia; Creatine; Darbepoetin alfa; Drug Administration Schedule; Erythropoietin; Female; Hematinics	2011
The effect of vitamin E-bonded dialyzer membrane on red blood cell survival in hemodialyzed patients. Artificial organs, 2003, Volume: 27, Issue:3 Topics: Adult; Anemia; Antioxidants; Cell Survival; Creatine; Erythrocyte Count; Erythrocytes; Female; Follo	2003
[STUDIES ON THE IMMEDIATE EFFECT OF TRANSFUSING PRESERVED BLOOD ON RENAL BLOOD SUPPLY AND GLOMERULAR FILTRATION]. Polskie Archiwum Medycyny Wewnetrznej, 1963, Volume: 33 Topics: Anemia; Blood Preservation; Blood Transfusion; Creatine; Creatinine; Humans; Iodopyracet; Kidney; Ki	1963
RESPONSE OF MACROCYTIC ANEMIA IN CHILDREN TO THE COENZYME Q4-CHROMANOL. The American journal of clinical nutrition, 1963, Volume: 13 Topics: Anemia; Anemia, Macrocytic; Blood Chemical Analysis; Child; Chromans; Creatine; Creatinine; Erythroc	1963
URINARY EXCRETION OF ZINC IN PATIENTS WITH THE SYNDROME OF ANEMIA, HEPATOSPLENOMEGALY, DWARFISM, AND HYPOGONADISM. The Journal of laboratory and clinical medicine, 1963, Volume: 62 Topics: Adolescent; Alkaline Phosphatase; Amebiasis; Anemia; Anemia, Hypochromic; Ascariasis; Aspartate Amin	1963
[RESULTS OF THE PRESENT STUDIES IN VAERMLAND AND GENERAL REMARKS ON HEALTH CONTROL BY DRUGS]. Svenska lakartidningen, 1964, May-20, Volume: 61 Topics: Alanine Transaminase; Anemia; Anemia, Hypochromic; Aspartate Aminotransferases; Blood Chemical Analy	1964
[RETENTION OF VITAMIN B12. A COMPARATIVE STUDY OF RETENTION AFTER INTRAMUSCULAR INJECTION OF CYANOCOBALAMIN AND HYDROOXOCOBALAMIN RESPECTIVELY]. Ugeskrift for laeger, 1964, Apr-16, Volume: 126 Topics: Anemia; Anemia, Pernicious; Blood Chemical Analysis; Creatine; Creatinine; Humans; Hydroxocobalamin;	1964
EFFECT OF HEMODIALYSIS ON ERYTHROKINETICS IN ANEMIA OF UREMIA. The Journal of laboratory and clinical medicine, 1964, Volume: 63 Topics: Adolescent; Amyloidosis; Anemia; Blood Cell Count; Creatine; Creatinine; Dialysis; Erythropoiesis; G	1964
HEMODIALYSIS FOR CHRONIC RENAL FAILURE. II. BIOCHEMICAL AND CLINICAL ASPECTS. Annals of internal medicine, 1965, Volume: 62 Topics: Anemia; Biochemical Phenomena; Biochemistry; Blood; Blood Pressure; Blood Urea Nitrogen; Calcium; Ch	1965
[EXPERIMENTAL CONTRIBUTION TO THE PATHOGENESIS OF RENAL ANEMIA]. Deutsches Archiv fur klinische Medizin, 1965, Apr-29, Volume: 211 Topics: Anemia; Creatine; Creatinine; Humans; Kidney Diseases; Urologic Diseases	1965
Pharmacokinetics, dosimetry, and toxicity of the targetable atomic generator, 225Ac-HuM195, in nonhuman primates. Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 2004, Volume: 45, Issue:1 Topics: Actinium; Anemia; Animals; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Creatine; Dose	2004
"Dilution anemia" associated with multiple infusions of a fat emulsion. The American journal of clinical nutrition, 1967, Volume: 20, Issue:7 Topics: Adult; Anemia; Chromium Isotopes; Creatine; Emulsions; Erythrocyte Aging; Fats; Feces; Humans; Infus	1967
Using red blood cell creatine concentration to evaluate the equine erythropoietic response. American journal of veterinary research, 1983, Volume: 44, Issue:8 Topics: Anemia; Animals; Creatine; Erythrocyte Aging; Erythrocyte Indices; Erythrocytes; Erythropoiesis; Fem	1983
[Creatine content in erythrocytes and blood plasma of chickens before and following stimulation of erythropoiesis by anemia]. Acta biologica et medica Germanica, 1980, Volume: 39, Issue:10 Topics: Anemia; Animals; Bloodletting; Chickens; Creatine; Erythrocytes; Erythropoiesis; Hydrolysis; Phenylh	1980
Biochemical changes in equine erythrocytes during experimental regenerative anemia. The Cornell veterinarian, 1981, Volume: 71, Issue:3 Topics: Anemia; Animals; Aspartate Aminotransferases; Creatine; Erythrocytes; Erythropoiesis; Glucosephospha	1981
[Effect of bushen shengxue recipe on EPO gene expression of chronic renal insufficiency anemia in rats]. Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine, 1995, Volume: 15, Issue:4 Topics: Anemia; Animals; Blood Urea Nitrogen; Creatine; Drugs, Chinese Herbal; Erythropoietin; Gene Expressi	1995
Alterations in the myocardial creatine kinase system during chronic anaemic hypoxia. Cardiovascular research, 1994, Volume: 28, Issue:1 Topics: Adenosine Diphosphate; Adenosine Triphosphate; Anemia; Animals; Cell Hypoxia; Chronic Disease; Creat	1994
Effects of combined parenteral vitamins C and E administration on the severity of anaemia, hepatic and renal damage in Trypanosoma brucei brucei infected rabbits. Veterinary parasitology, 1999, Aug-16, Volume: 85, Issue:1 Topics: Alanine Transaminase; Anemia; Animals; Ascorbic Acid; Aspartate Aminotransferases; Creatine; Hematoc	1999
Chronic uremia induces permeability changes, increased nitric oxide synthase expression, and structural modifications in the peritoneum. Journal of the American Society of Nephrology : JASN, 2001, Volume: 12, Issue:10 Topics: Anemia; Animals; Chronic Disease; Creatine; Erythropoietin; Growth Substances; Kidney Failure, Chron	2001
Creatine during bleeding anemia of rabbits. Acta biologica et medica Germanica, 1977, Volume: 36, Issue:3-4 Topics: Anemia; Animals; Creatine; Erythrocytes; Hematocrit; Hemorrhage; Mice; Oxygen Consumption; Rabbits;	1977
Inhibitors of erythroid colony-forming cells (CFU-E and BFU-E) in sera of azotemic patients with anemia of renal disease. The Journal of laboratory and clinical medicine, 1978, Volume: 92, Issue:6 Topics: Anemia; Bone Marrow Cells; Creatine; Erythropoiesis; Guanidines; Humans; Renal Dialysis; Uremia	1978
Brain energy metabolism in anesthetized rats in acute anemia. Acta physiologica Scandinavica, 1975, Volume: 93, Issue:4 Topics: Acute Disease; Adenine Nucleotides; Anemia; Animals; Blood Pressure; Brain; Carbon Dioxide; Cerebrov	1975
Low-dose subcutaneous erythropoietin in continuous ambulatory peritoneal dialysis. American journal of hematology, 1991, Volume: 37, Issue:1 Topics: Adult; Aged; Anemia; Creatine; Dose-Response Relationship, Drug; Erythropoietin; Female; Hematocrit;	1991
Evaluation of indicators of erythropoiesis stimulated by recombinant human erythropoietin in renal anemia. Biomedica biochimica acta, 1990, Volume: 49, Issue:2-3 Topics: Adolescent; Anemia; Child; Creatine; Erythrocytes; Erythropoiesis; Erythropoietin; Hematocrit; Human	1990
Correction of anaemia following renal transplantation: serial changes in serum immunoreactive erythropoietin, absolute reticulocyte count and red-cell creatine levels. British journal of haematology, 1985, Volume: 61, Issue:3 Topics: Adult; Anemia; Creatine; Erythrocyte Count; Erythropoietin; Female; Graft Rejection; Hemoglobins; Hu	1985
The red blood cell as a model for the study of uremic toxins. Archives of internal medicine, 1970, Volume: 126, Issue:5 Topics: Acetates; Adenosine Triphosphatases; Anemia; Biological Transport, Active; Cell Membrane; Creatine;	1970
Progress with jejunal loop dialysis. British journal of urology, 1972, Volume: 44, Issue:6 Topics: Adult; Anemia; Creatine; Female; Glucuronates; Humans; Hypertension, Renal; Indoles; Jejunum; Kidney	1972
Oxygen affinity of hemoglobin and red cell 2,3-diphosphoglycerate in hepatic cirrhosis. Scandinavian journal of clinical and laboratory investigation, 1973, Volume: 31, Issue:3 Topics: Acid-Base Equilibrium; Ammonium Chloride; Anemia; Blood; Creatine; Diphosphoglyceric Acids; Erythroc	1973
Hematopoietic activity of hexahydrocoenzyme Q4 in the monkey. Archives of biochemistry and biophysics, 1967, Volume: 121, Issue:3 Topics: Anemia; Animals; Antioxidants; Creatine; Creatinine; Diet; Electron Transport; Haplorhini; Hematopoi	1967
Chronic deficits in red-cell mass in patients with orthopaedic injuries (stress anemia). The Journal of bone and joint surgery. American volume, 1972, Volume: 54, Issue:5 Topics: Adult; Anemia; Arm Injuries; Blood Preservation; Blood Transfusion; Blood Volume; Chromium Isotopes;	1972
Oxyhemoglobin dissociation curve in hemorrhagic and septic shock. Advances in experimental medicine and biology, 1971, Volume: 23, Issue:0 Topics: Adult; Anemia; Blood Transfusion; Cardiac Output; Creatine; Diphosphoglyceric Acids; Erythrocytes; F	1971
Is red-cell creatine metabolic garbage? The New England journal of medicine, 1970, Apr-23, Volume: 282, Issue:17 Topics: Acidosis; Anemia; Creatine; Erythrocytes; Hemoglobins; Humans; Oxygen	1970
Criteria for the evaluation of the severity of established renal disease. Council on the Kidney in Cardiovascular disease. American Heart Association, 1971. Annals of internal medicine, 1971, Volume: 75, Issue:2 Topics: Acidosis; Anemia; Coma; Creatine; Glomerular Filtration Rate; Hypertension; Kidney; Kidney Diseases;	1971
Creatine, 2,3-diphosphoglycerate and anemia. The New England journal of medicine, 1971, Aug-26, Volume: 285, Issue:9 Topics: Anemia; Anemia, Aplastic; Anemia, Hemolytic, Autoimmune; Anemia, Hypochromic; Anemia, Sickle Cell; A	1971
[Excretion of delta-aminolevulinic acid and porphobilinogen in the course of pregnancy in relation to anemia]. Ginekologia polska, 1969, Volume: 40, Issue:1 Topics: Adolescent; Adult; Anemia; Creatine; Erythrocyte Count; Female; Hemoglobins; Humans; Levulinic Acids	1969

creatine and Anemia

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