creatine has been researched along with Age-Related Memory Disorders in 26 studies
| Excerpt | Relevance | Reference |
|---|---|---|
| "In the present study, we investigate the effect of severe hyperhomocysteinemia on biochemical (creatine kinase activity), behavioral (memory tests), and histological assessments (hippocampal volume)." | 7.85 | Severe Hyperhomocysteinemia Decreases Creatine Kinase Activity and Causes Memory Impairment: Neuroprotective Role of Creatine. ( Carletti, J; Dos Santos, TM; Kolling, J; Longoni, A; Marques, EP; Pereira, LO; Siebert, C; Wyse, ATS, 2017) |
| "In the present study, we investigate the effect of severe hyperhomocysteinemia on biochemical (creatine kinase activity), behavioral (memory tests), and histological assessments (hippocampal volume)." | 3.85 | Severe Hyperhomocysteinemia Decreases Creatine Kinase Activity and Causes Memory Impairment: Neuroprotective Role of Creatine. ( Carletti, J; Dos Santos, TM; Kolling, J; Longoni, A; Marques, EP; Pereira, LO; Siebert, C; Wyse, ATS, 2017) |
| "Obsessive-compulsive disorder (OCD) and major depressive disorder (MDD) both showed cognitive impairment, and the altered neurometabolic may associate with cognitive impairment." | 1.72 | Similarities and differences in working memory and neurometabolism of obsessive-compulsive disorder and major depressive disorder. ( Chen, G; Chen, P; He, J; Jia, Y; Lai, S; Lu, Q; Song, Z; Wang, Y; Yan, S; Zhang, Y; Zhao, H; Zhong, S, 2022) |
| "Creatine (Cr) is a guanidino compound that provides readily available phosphate pools for the regeneration of spent adenosine triphosphate (ATP)." | 1.51 | Deletion of the creatine transporter gene in neonatal, but not adult, mice leads to cognitive deficits. ( Abdulla, ZI; Delcimmuto, N; Kokenge, AN; Perna, MK; Skelton, MR; Udobi, KC, 2019) |
| "Mice were tested for learning and memory deficits and assayed for Cr and neurotransmitter levels." | 1.37 | Creatine transporter (CrT; Slc6a8) knockout mice as a model of human CrT deficiency. ( Clark, JF; Degrauw, TJ; Graham, DL; Schaefer, TL; Skelton, MR; Vorhees, CV; Williams, MT, 2011) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (3.85) | 18.2507 |
| 2000's | 11 (42.31) | 29.6817 |
| 2010's | 11 (42.31) | 24.3611 |
| 2020's | 3 (11.54) | 2.80 |
| Authors | Studies |
|---|---|
| He, J | 1 |
| Yan, S | 1 |
| Song, Z | 1 |
| Lu, Q | 2 |
| Zhong, S | 2 |
| Lai, S | 2 |
| Wang, Y | 2 |
| Chen, G | 1 |
| Zhao, H | 2 |
| Chen, P | 1 |
| Zhang, Y | 1 |
| Jia, Y | 2 |
| Bahari, Z | 1 |
| Jangravi, Z | 1 |
| Hatef, B | 1 |
| Valipour, H | 1 |
| Meftahi, GH | 1 |
| Mao, X | 1 |
| Kelty, TJ | 1 |
| Kerr, NR | 1 |
| Childs, TE | 1 |
| Roberts, MD | 1 |
| Booth, FW | 1 |
| Kolling, J | 1 |
| Longoni, A | 1 |
| Siebert, C | 1 |
| Dos Santos, TM | 1 |
| Marques, EP | 1 |
| Carletti, J | 1 |
| Pereira, LO | 1 |
| Wyse, ATS | 1 |
| Shan, Y | 1 |
| Li, X | 1 |
| Chen, J | 1 |
| Zhang, L | 2 |
| Li, Z | 1 |
| Udobi, KC | 3 |
| Kokenge, AN | 3 |
| Hautman, ER | 2 |
| Ullio, G | 1 |
| Coene, J | 1 |
| Williams, MT | 3 |
| Vorhees, CV | 3 |
| Mabondzo, A | 1 |
| Skelton, MR | 4 |
| Delcimmuto, N | 1 |
| Abdulla, ZI | 1 |
| Perna, MK | 1 |
| Calderón-Garcidueñas, L | 1 |
| Mora-Tiscareño, A | 1 |
| Franco-Lira, M | 1 |
| Zhu, H | 1 |
| Lu, Z | 1 |
| Solorio, E | 1 |
| Torres-Jardón, R | 1 |
| D'Angiulli, A | 1 |
| Mazgaj, R | 1 |
| Tal, A | 1 |
| Goetz, R | 1 |
| Lazar, M | 1 |
| Rothman, K | 1 |
| Messinger, JW | 1 |
| Malaspina, D | 1 |
| Gonen, O | 1 |
| Yoon, KJ | 1 |
| Lee, YT | 1 |
| Chae, SW | 1 |
| Park, CR | 1 |
| Kim, DY | 1 |
| Moon, CM | 1 |
| Sundaram, T | 1 |
| Choi, NG | 1 |
| Jeong, GW | 1 |
| Mantoan, MA | 1 |
| Caboclo, LO | 1 |
| de Figueiredo Ferreira Guilhoto, LM | 1 |
| Lin, K | 1 |
| da Silva Noffs, MH | 1 |
| de Souza Silva Tudesco, I | 1 |
| Belzunces, E | 1 |
| Carrete, H | 1 |
| Bussoletti, RT | 1 |
| Centeno, RS | 1 |
| Sakamoto, AC | 1 |
| Yacubian, EM | 1 |
| Schaefer, TL | 1 |
| Graham, DL | 1 |
| Degrauw, TJ | 1 |
| Clark, JF | 1 |
| Kozora, E | 1 |
| Brown, MS | 1 |
| Filley, CM | 1 |
| Miller, DE | 1 |
| West, SG | 1 |
| Pelzman, J | 1 |
| Arciniegas, DB | 1 |
| Bertolino, A | 1 |
| Sciota, D | 1 |
| Brudaglio, F | 1 |
| Altamura, M | 1 |
| Blasi, G | 1 |
| Bellomo, A | 1 |
| Antonucci, N | 1 |
| Callicott, JH | 1 |
| Goldberg, TE | 1 |
| Scarabino, T | 1 |
| Weinberger, DR | 1 |
| Nardini, M | 1 |
| Weiss, U | 1 |
| Bacher, R | 1 |
| Vonbank, H | 1 |
| Kemmler, G | 1 |
| Lingg, A | 1 |
| Marksteiner, J | 1 |
| Assini, A | 1 |
| Cammarata, S | 1 |
| Vitali, A | 1 |
| Colucci, M | 1 |
| Giliberto, L | 1 |
| Borghi, R | 1 |
| Inglese, ML | 1 |
| Volpe, S | 1 |
| Ratto, S | 1 |
| Dagna-Bricarelli, F | 1 |
| Baldo, C | 1 |
| Argusti, A | 1 |
| Odetti, P | 1 |
| Piccini, A | 1 |
| Tabaton, M | 1 |
| Frederick, BD | 1 |
| Lyoo, IK | 1 |
| Satlin, A | 1 |
| Ahn, KH | 1 |
| Kim, MJ | 1 |
| Yurgelun-Todd, DA | 1 |
| Cohen, BM | 1 |
| Renshaw, PF | 1 |
| Metastasio, A | 1 |
| Rinaldi, P | 1 |
| Tarducci, R | 1 |
| Mariani, E | 1 |
| Feliziani, FT | 1 |
| Cherubini, A | 1 |
| Pelliccioli, GP | 1 |
| Gobbi, G | 1 |
| Senin, U | 1 |
| Mecocci, P | 1 |
| Vasques, V | 1 |
| Brinco, F | 1 |
| Viegas, CM | 1 |
| Wajner, M | 1 |
| Hermann, D | 1 |
| Sartorius, A | 1 |
| Welzel, H | 1 |
| Walter, S | 2 |
| Skopp, G | 1 |
| Ende, G | 2 |
| Mann, K | 1 |
| Zimmerman, ME | 1 |
| Pan, JW | 1 |
| Hetherington, HP | 1 |
| Katz, MJ | 1 |
| Verghese, J | 1 |
| Buschke, H | 1 |
| Derby, CA | 1 |
| Lipton, RB | 1 |
| Buckley, PF | 1 |
| Moore, C | 1 |
| Long, H | 1 |
| Larkin, C | 1 |
| Thompson, P | 1 |
| Mulvany, F | 1 |
| Redmond, O | 1 |
| Stack, JP | 1 |
| Ennis, JT | 1 |
| Waddington, JL | 1 |
| Braus, DF | 1 |
| Weber-Fahr, W | 1 |
| Henn, FA | 1 |
| Lin, A | 1 |
| Nguy, CH | 1 |
| Shic, F | 1 |
| Ross, BD | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| An Open-label Exploratory Study With Memantine: Correlation Between Proton Magnetic Resonance Spectroscopy, Cerebrospinal Fluid Biomarkers, and Cognition in Patients With Mild to Moderate Alzheimer's Disease[NCT00551161] | Phase 4 | 12 participants (Actual) | Interventional | 2007-08-31 | Completed | ||
| Effects of Cannabidiol (CBD) on the Brain[NCT04831294] | 15 participants (Actual) | Interventional | 2021-07-15 | Active, not recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Ratios of myo-inositol (mI), N-acetylaspartate (NAA), total creatine (Cr), and choline (Cho) by single voxel 1H MRS (proton magnetic resonance spectroscopy). Mean (± SD) metabolite levels (normalized to T2-corrected water signal intensity) and metabolite ratios for Alzheimer's disease subjects at baseline (t0), after 24 weeks of ongoing monotherapy with stable-dose cholinesterase inhibitor (t1), and after another 24 weeks of combination therapy with memantine in addition to stable-dose cholinesterase inhibitor (t2). The Wilcoxon signed-rank test was used to examine whether the change between t0 and t1 differed from the change between t1 and t2 [(t2 - t1) - (t1 - t0)]. (NCT00551161)
Timeframe: Baseline, 24 weeks, and 48 weeks
| Intervention | ratio (normalized to T2-corrected water (Mean) | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| Change in NAA [(t2-t1) - (t1-t0)] | Change in Cr [(t2-t1) - (t1-t0)] | Change in Cho [(t2-t1) - (t1-t0)] | Change in mI [(t2-t1) - (t1-t0)] | Change in NAA/Cr [(t2-t1) - (t1-t0)] | Change in Cho/Cr [(t2-t1) - (t1-t0)] | Change in mI/Cr [(t2-t1) - (t1-t0)] | Change in NAA/Cho [(t2-t1) - (t1-t0)] | Change in NAA/mI [(t2-t1) - (t1-t0)] | |
| Memantine | -54 | -2 | 9 | 16 | -0.09 | 0.02 | 0.04 | -0.26 | -0.35 |
1 trial available for creatine and Age-Related Memory Disorders
| Article | Year |
|---|---|
Accumulation of methylsulfonylmethane in the human brain: identification by multinuclear magnetic resonance spectroscopy.
Topics: Administration, Oral; Adult; Aged; Aspartic Acid; Brain; Brain Chemistry; Choline; Creatine; Dimethy | 2001 |
25 other studies available for creatine and Age-Related Memory Disorders
| Article | Year |
|---|---|
Similarities and differences in working memory and neurometabolism of obsessive-compulsive disorder and major depressive disorder.
Topics: Creatine; Depressive Disorder, Major; Humans; Magnetic Resonance Imaging; Memory Disorders; Memory, | 2022 |
Creatine supplementation protects spatial memory and long-term potentiation against chronic restraint stress.
Topics: Animals; Creatine; Dietary Supplements; Hippocampus; Long-Term Potentiation; Male; Maze Learning; Me | 2023 |
Creatine Supplementation Upregulates mTORC1 Signaling and Markers of Synaptic Plasticity in the Dentate Gyrus While Ameliorating LPS-Induced Cognitive Impairment in Female Rats.
Topics: Animal Nutritional Physiological Phenomena; Animals; Behavior, Animal; Cognitive Dysfunction; Creati | 2021 |
Severe Hyperhomocysteinemia Decreases Creatine Kinase Activity and Causes Memory Impairment: Neuroprotective Role of Creatine.
Topics: Animals; Creatine; Creatine Kinase; Female; Hippocampus; Homeostasis; Hyperhomocysteinemia; Male; Me | 2017 |
Correlations between working memory impairment and neurometabolites of prefrontal cortex and lenticular nucleus in patients with major depressive disorder.
Topics: Adult; Aspartic Acid; Case-Control Studies; Choline; Corpus Striatum; Creatine; Depressive Disorder, | 2018 |
Cognitive deficits and increases in creatine precursors in a brain-specific knockout of the creatine transporter gene Slc6a8.
Topics: Animals; Brain; Brain Diseases, Metabolic, Inborn; Cognitive Dysfunction; Creatine; Fear; Learning; | 2018 |
Deletion of the creatine transporter gene in neonatal, but not adult, mice leads to cognitive deficits.
Topics: Animals; Brain; Brain Diseases, Metabolic, Inborn; Cognitive Dysfunction; Creatine; Fear; Female; Ma | 2019 |
Female mice heterozygous for creatine transporter deficiency show moderate cognitive deficits.
Topics: Animals; Behavior, Animal; Brain; Brain Diseases, Metabolic, Inborn; Cognition Disorders; Creatine; | 2014 |
Decreases in Short Term Memory, IQ, and Altered Brain Metabolic Ratios in Urban Apolipoprotein ε4 Children Exposed to Air Pollution.
Topics: Adolescent; Age Factors; Air Pollution; Analysis of Variance; Apolipoprotein E4; Aspartic Acid; Brai | 2015 |
Hypo-metabolism of the rostral anterior cingulate cortex associated with working memory impairment in 18 cases of schizophrenia.
Topics: Adult; Aging; Aspartic Acid; Creatine; Female; Gliosis; Gyrus Cinguli; Humans; Inositol; Intelligenc | 2016 |
Effects of anodal transcranial direct current stimulation (tDCS) on behavioral and spatial memory during the early stage of traumatic brain injury in the rats.
Topics: Analysis of Variance; Animals; Aspartic Acid; Brain Edema; Brain Injuries, Traumatic; Brain-Derived | 2016 |
Working memory dysfunction associated with brain functional deficits and cellular metabolic changes in patients with generalized anxiety disorder.
Topics: Adult; Anxiety Disorders; Aspartic Acid; Brain; Brain Mapping; Case-Control Studies; Choline; Creati | 2016 |
Correlation between memory, proton magnetic resonance spectroscopy, and interictal epileptiform discharges in temporal lobe epilepsy related to mesial temporal sclerosis.
Topics: Adult; Aspartic Acid; Choline; Creatine; Epilepsy, Temporal Lobe; Female; Functional Laterality; Hum | 2009 |
Creatine transporter (CrT; Slc6a8) knockout mice as a model of human CrT deficiency.
Topics: Animals; Brain Chemistry; Creatine; Disease Models, Animal; Female; Humans; Indoles; Learning Disabi | 2011 |
Memory impairment associated with neurometabolic abnormalities of the hippocampus in patients with non-neuropsychiatric systemic lupus erythematosus.
Topics: Adult; Aspartic Acid; Case-Control Studies; Creatine; Female; Glutamic Acid; Hippocampus; Humans; Lu | 2011 |
Working memory deficits and levels of N-acetylaspartate in patients with schizophreniform disorder.
Topics: Adult; Aspartic Acid; Creatine; Female; Hippocampus; Humans; Magnetic Resonance Spectroscopy; Male; | 2003 |
Cognitive impairment: assessment with brain magnetic resonance imaging and proton magnetic resonance spectroscopy.
Topics: Aged; Alzheimer Disease; Aspartic Acid; Brain; Brain Chemistry; Choline; Cognition Disorders; Creati | 2003 |
Plasma levels of amyloid beta-protein 42 are increased in women with mild cognitive impairment.
Topics: Age of Onset; Aged; Alzheimer Disease; Amyloid beta-Peptides; Apolipoproteins E; Biomarkers; Cholest | 2004 |
In vivo proton magnetic resonance spectroscopy of the temporal lobe in Alzheimer's disease.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Analysis of Variance; Aspartic Acid; Brain Mapping; Case | 2004 |
Conversion of MCI to dementia: Role of proton magnetic resonance spectroscopy.
Topics: Aged; Amnesia; Aspartic Acid; Cerebral Cortex; Choline; Cognition Disorders; Creatine; Dementia; Dis | 2006 |
Creatine prevents behavioral alterations caused by methylmalonic acid administration into the hippocampus of rats in the open field task.
Topics: Animals; Avoidance Learning; Brain Diseases, Metabolic, Inborn; Creatine; Disease Models, Animal; En | 2006 |
Dorsolateral prefrontal cortex N-acetylaspartate/total creatine (NAA/tCr) loss in male recreational cannabis users.
Topics: Adult; Alcohol Drinking; Aspartic Acid; Attention; Creatine; Globus Pallidus; Gyrus Cinguli; Hair; H | 2007 |
Hippocampal neurochemistry, neuromorphometry, and verbal memory in nondemented older adults.
Topics: Aged; Aged, 80 and over; Aging; Aspartic Acid; Creatine; Female; Hippocampus; Humans; Magnetic Reson | 2008 |
1H-magnetic resonance spectroscopy of the left temporal and frontal lobes in schizophrenia: clinical, neurodevelopmental, and cognitive correlates.
Topics: Adult; Choline; Cognition Disorders; Creatine; Female; Frontal Lobe; Humans; Magnetic Resonance Spec | 1994 |
The hippocampus in patients treated with electroconvulsive therapy: a proton magnetic resonance spectroscopic imaging study.
Topics: Adult; Aspartic Acid; Cell Death; Choline; Creatine; Electroconvulsive Therapy; Female; Hippocampus; | 2000 |