creatine has been researched along with Acute Relapsing Multiple Sclerosis in 27 studies
| Excerpt | Relevance | Reference |
|---|---|---|
| "Citrulline was more frequently identified in the brains of patients with early-onset MS than in healthy subjects by (1)H-MR spectroscopy, suggesting an association of increased citrullination of myelin proteins with demyelinating diseases." | 5.14 | Assessment of citrullinated myelin by 1H-MR spectroscopy in early-onset multiple sclerosis. ( Aksu, AO; Anlar, B; Haspolat, S; Karabulut, E; Kurne, A; Kurul, S; Oguz, KK; Senbil, N; Serdaroglu, A; Teber, S, 2009) |
| "Compared to healthy controls, the RRMS group showed significantly higher fatigue and lower metabolic ratios for tyrosine, glutathione, homocarnosine (GSH+Hca), fucose-3, glutamine+glutamate (Glx), glycerophosphocholine (GPC), total choline, and N-acetylaspartate (NAA-2), while increased levels for isoleucine and glucose (P ≤ ." | 4.02 | Biochemical Correlations with Fatigue in Multiple Sclerosis Detected by MR 2D Localized Correlated Spectroscopy. ( Al-Iedani, O; Arm, J; Lea, R; Lechner-Scott, J; Ramadan, S; Ribbons, K, 2021) |
| " Concentrations of glutamate + glutamin (Glx), cholin (Cho), myoinositol (mIns), N-acetyl aspartate (NAA) expressed as ratio with creatine (Cr) and NAA were correlated with markers of disease activity (RIO score), Multiple Sclerosis Severity Scale (MSSS), Depressive-Severity Status Scale and Simple Numerical Fatigue Scale." | 3.85 | Hypothalamic damage in multiple sclerosis correlates with disease activity, disability, depression, and fatigue. ( Baranovičová, E; Bittšanský, M; Čierny, D; Hnilicová, P; Kantorová, E; Kurča, E; Nosáľ, V; Poláček, H; Sivák, Š; Zeleňák, K, 2017) |
| "Fatigue was assessed by the Fatigue Severity Scale (FSS) and the Modified Fatigue Impact Scale (MFIS)." | 1.35 | The basal ganglia: a substrate for fatigue in multiple sclerosis. ( Alonso, J; Montalban, X; Nos, C; Río, J; Rovira, A; Téllez, N; Tintoré, M, 2008) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 17 (62.96) | 29.6817 |
| 2010's | 9 (33.33) | 24.3611 |
| 2020's | 1 (3.70) | 2.80 |
| Authors | Studies |
|---|---|
| Arm, J | 1 |
| Al-Iedani, O | 1 |
| Ribbons, K | 1 |
| Lea, R | 1 |
| Lechner-Scott, J | 1 |
| Ramadan, S | 1 |
| Schneider, R | 1 |
| Bellenberg, B | 1 |
| Hoepner, R | 1 |
| Kolb, EM | 1 |
| Ellrichmann, G | 1 |
| Haghikia, A | 1 |
| Gold, R | 1 |
| Lukas, C | 1 |
| Kirov, II | 3 |
| Liu, S | 3 |
| Tal, A | 2 |
| Wu, WE | 1 |
| Davitz, MS | 1 |
| Babb, JS | 5 |
| Rusinek, H | 1 |
| Herbert, J | 3 |
| Gonen, O | 6 |
| Zhou, L | 1 |
| Fan, Y | 1 |
| Yetkin, MF | 1 |
| Mirza, M | 1 |
| Dönmez, H | 1 |
| Kantorová, E | 1 |
| Poláček, H | 1 |
| Bittšanský, M | 1 |
| Baranovičová, E | 1 |
| Hnilicová, P | 1 |
| Čierny, D | 1 |
| Sivák, Š | 1 |
| Nosáľ, V | 1 |
| Zeleňák, K | 1 |
| Kurča, E | 1 |
| Oguz, KK | 1 |
| Kurne, A | 1 |
| Aksu, AO | 1 |
| Karabulut, E | 1 |
| Serdaroglu, A | 1 |
| Teber, S | 1 |
| Haspolat, S | 1 |
| Senbil, N | 1 |
| Kurul, S | 1 |
| Anlar, B | 1 |
| Fleysher, R | 1 |
| Fleysher, L | 1 |
| Zeller, D | 1 |
| aufm Kampe, K | 1 |
| Biller, A | 1 |
| Stefan, K | 1 |
| Gentner, R | 1 |
| Schütz, A | 1 |
| Bartsch, A | 1 |
| Bendszus, M | 1 |
| Toyka, KV | 1 |
| Rieckmann, P | 1 |
| Classen, J | 1 |
| Blinkenberg, M | 1 |
| Mathiesen, HK | 2 |
| Tscherning, T | 2 |
| Jønsson, A | 1 |
| Svarer, C | 1 |
| Holm, S | 1 |
| Sellebjerg, F | 1 |
| Paulson, OB | 2 |
| Hanson, LG | 2 |
| Sorensen, PS | 2 |
| Pan, JW | 1 |
| Coyle, PK | 1 |
| Bashir, K | 1 |
| Whitaker, JN | 1 |
| Krupp, LB | 1 |
| Hetherington, HP | 1 |
| Li, BS | 2 |
| Regal, J | 1 |
| Soher, BJ | 2 |
| Mannon, LJ | 2 |
| Grossman, RI | 3 |
| Ruiz-Peña, JL | 1 |
| Piñero, P | 1 |
| Sellers, G | 1 |
| Argente, J | 1 |
| Casado, A | 1 |
| Foronda, J | 1 |
| Uclés, A | 1 |
| Izquierdo, G | 1 |
| Inglese, M | 2 |
| He, J | 1 |
| Larsson, HB | 1 |
| Rostrup, E | 1 |
| Sijens, PE | 1 |
| Mostert, JP | 1 |
| Oudkerk, M | 1 |
| De Keyser, J | 1 |
| Tiberio, M | 1 |
| Chard, DT | 1 |
| Altmann, DR | 1 |
| Davies, G | 1 |
| Griffin, CM | 1 |
| McLean, MA | 1 |
| Rashid, W | 1 |
| Sastre-Garriga, J | 1 |
| Thompson, AJ | 1 |
| Miller, DH | 1 |
| Khan, O | 1 |
| Shen, Y | 1 |
| Caon, C | 1 |
| Bao, F | 1 |
| Ching, W | 1 |
| Reznar, M | 1 |
| Buccheister, A | 1 |
| Hu, J | 1 |
| Latif, Z | 1 |
| Tselis, A | 1 |
| Lisak, R | 1 |
| Pascual, AM | 1 |
| Martínez-Bisbal, MC | 1 |
| Boscá, I | 1 |
| Valero, C | 1 |
| Coret, F | 1 |
| Martínez-Granados, B | 1 |
| Marti-Bonmati, L | 1 |
| Mir, A | 1 |
| Celda, B | 1 |
| Casanova, B | 1 |
| Téllez, N | 1 |
| Alonso, J | 1 |
| Río, J | 1 |
| Tintoré, M | 1 |
| Nos, C | 1 |
| Montalban, X | 1 |
| Rovira, A | 1 |
| Suhy, J | 1 |
| Rooney, WD | 1 |
| Goodkin, DE | 1 |
| Capizzano, AA | 1 |
| Maudsley, AA | 1 |
| Waubant, E | 1 |
| Andersson, PB | 1 |
| Weiner, MW | 1 |
| Mader, I | 1 |
| Roser, W | 1 |
| Kappos, L | 1 |
| Hagberg, G | 1 |
| Seelig, J | 1 |
| Radue, EW | 1 |
| Steinbrich, W | 1 |
| Helms, G | 1 |
| Pozdniakov, AV | 1 |
| Tiutin, LA | 1 |
| Bisaga, GN | 1 |
| Odinak, MM | 1 |
| Schubert, F | 1 |
| Seifert, F | 1 |
| Elster, C | 1 |
| Link, A | 1 |
| Walzel, M | 1 |
| Mientus, S | 1 |
| Haas, J | 1 |
| Rinneberg, H | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| An Open-label, Non-randomized, Phase I/II Study of Autologous Bone Marrow-Derived Mononuclear Stem Cells (BM-MNC) and Liberation Therapy (When Associated With CCSVI) in Patients With RRMS[NCT02587806] | Phase 1/Phase 2 | 69 participants (Anticipated) | Interventional | 2015-02-28 | Recruiting | ||
| An Open-label, Non-randomized, Phase I/II Study of Allogeneic Human Umbilical Cord Tissue-Derived Mesenchymal Stem Cells (UC-MSC) and Liberation Therapy (When Associated With Chronic Cerebrovascular Venous Insufficiency) in Patients With Relapsing Remitti[NCT02587715] | Phase 1/Phase 2 | 69 participants (Anticipated) | Interventional | 2015-02-28 | Recruiting | ||
| An Open-label, Non-randomized, Phase I/II Study of Allogeneic Human Umbilical Cord Tissue-Derived Mesenchymal Stem Cells (UC-MSC) and Liberation Therapy (When Associated With Chronic Cerebrovascular Venous Insufficiency) in Patients With Relapsing Remitti[NCT02418325] | Phase 1/Phase 2 | 69 participants (Anticipated) | Interventional | 2015-02-28 | Terminated (stopped due to Lack of funding) | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
6 trials available for creatine and Acute Relapsing Multiple Sclerosis
| Article | Year |
|---|---|
Randomized trial of erhuangfang for relapsing multiple sclerosis.
Topics: Adolescent; Adult; Anti-Inflammatory Agents; Aspartic Acid; Brain; Creatine; Disability Evaluation; | 2015 |
Assessment of citrullinated myelin by 1H-MR spectroscopy in early-onset multiple sclerosis.
Topics: Adolescent; Age of Onset; Aspartic Acid; Child; Child, Preschool; Choline; Citrulline; Creatine; Dem | 2009 |
Magnetic resonance spectroscopy of normal appearing white matter in early relapsing-remitting multiple sclerosis: correlations between disability and spectroscopy.
Topics: Adolescent; Adult; Aged; Aspartic Acid; Axons; Biomarkers; Brain; Creatine; Cross-Sectional Studies; | 2004 |
Axonal metabolic recovery and potential neuroprotective effect of glatiramer acetate in relapsing-remitting multiple sclerosis.
Topics: Adult; Aspartic Acid; Axons; Creatine; Female; Glatiramer Acetate; Humans; Immunosuppressive Agents; | 2005 |
Serial proton MR spectroscopy of contrast-enhancing multiple sclerosis plaques: absolute metabolic values over 2 years during a clinical pharmacological study.
Topics: Adult; Aspartic Acid; Brain; Choline; Creatine; Female; Follow-Up Studies; Guanidines; Humans; Image | 2000 |
Serial 1H-MRS in relapsing-remitting multiple sclerosis: effects of interferon-beta therapy on absolute metabolite concentrations.
Topics: Adult; Aspartic Acid; Brain; Choline; Creatine; Female; Humans; Image Enhancement; Interferon-beta; | 2002 |
21 other studies available for creatine and Acute Relapsing Multiple Sclerosis
| Article | Year |
|---|---|
Biochemical Correlations with Fatigue in Multiple Sclerosis Detected by MR 2D Localized Correlated Spectroscopy.
Topics: Adult; Aspartic Acid; Carnosine; Choline; Creatine; Fatigue; Female; Glutathione; Gyrus Cinguli; Hum | 2021 |
Metabolic profiles by 1H-magnetic resonance spectroscopy in natalizumab-associated post-PML lesions of multiple sclerosis patients who survived progressive multifocal leukoencephalopathy (PML).
Topics: Adult; Aspartic Acid; Brain; Choline; Creatine; Female; Humans; Immunologic Factors; JC Virus; Leuko | 2017 |
Proton MR spectroscopy of lesion evolution in multiple sclerosis: Steady-state metabolism and its relationship to conventional imaging.
Topics: Adult; Aspartic Acid; Brain; Choline; Creatine; Cross-Sectional Studies; Disease Progression; Female | 2017 |
Monitoring interferon β treatment response with magnetic resonance spectroscopy in relapsing remitting multiple sclerosis.
Topics: Adult; Aftercare; Aspartic Acid; Case-Control Studies; Chlorine; Creatine; Disability Evaluation; Fe | 2016 |
Hypothalamic damage in multiple sclerosis correlates with disease activity, disability, depression, and fatigue.
Topics: Adult; Aging; Aspartic Acid; Case-Control Studies; Choline; Creatine; Cross-Sectional Studies; Depre | 2017 |
Brain metabolite proton T2 mapping at 3.0 T in relapsing-remitting multiple sclerosis.
Topics: Adult; Aspartic Acid; Brain Mapping; Choline; Creatine; Female; Humans; Image Processing, Computer-A | 2010 |
Rapid-onset central motor plasticity in multiple sclerosis.
Topics: Adult; Aspartic Acid; Creatine; Cross-Sectional Studies; Female; Humans; Learning; Male; Middle Aged | 2010 |
Cerebral metabolism, magnetic resonance spectroscopy and cognitive dysfunction in early multiple sclerosis: an exploratory study.
Topics: Adult; Aspartic Acid; Brain; Cerebral Cortex; Cognition Disorders; Creatine; Female; Glucose; Humans | 2012 |
Serial proton MR spectroscopy of gray and white matter in relapsing-remitting MS.
Topics: Adult; Aspartic Acid; Brain; Case-Control Studies; Choline; Creatine; Disability Evaluation; Female; | 2013 |
Metabolic differences between multiple sclerosis subtypes measured by quantitative MR spectroscopy.
Topics: Aspartic Acid; Brain; Choline; Creatine; Female; Humans; Magnetic Resonance Spectroscopy; Male; Mult | 2002 |
Brain metabolite profiles of T1-hypointense lesions in relapsing-remitting multiple sclerosis.
Topics: Adult; Aspartic Acid; Brain; Choline; Creatine; Energy Metabolism; Female; Humans; Image Processing, | 2003 |
Three-dimensional proton spectroscopy of deep gray matter nuclei in relapsing-remitting MS.
Topics: Adult; Aspartic Acid; Basal Ganglia; Choline; Creatine; Female; Humans; Imaging, Three-Dimensional; | 2004 |
Relapsing-remitting multiple sclerosis: metabolic abnormality in nonenhancing lesions and normal-appearing white matter at MR imaging: initial experience.
Topics: Adult; Aspartic Acid; Brain; Case-Control Studies; Choline; Creatine; Female; Humans; Imaging, Three | 2005 |
Multi-slice echo-planar spectroscopic MR imaging provides both global and local metabolite measures in multiple sclerosis.
Topics: Adult; Aspartic Acid; Brain; Case-Control Studies; Choline; Creatine; Echo-Planar Imaging; Female; H | 2005 |
(1)H MR spectroscopy of the brain in multiple sclerosis subtypes with analysis of the metabolite concentrations in gray and white matter: initial findings.
Topics: Adult; Aspartic Acid; Brain; Choline; Creatine; Energy Metabolism; Female; Humans; Image Processing, | 2006 |
Metabolite changes in early relapsing-remitting multiple sclerosis. A two year follow-up study.
Topics: Adult; Aspartic Acid; Choline; Creatine; Dipeptides; Female; Follow-Up Studies; Glutamic Acid; Human | 2006 |
Axonal loss is progressive and partly dissociated from lesion load in early multiple sclerosis.
Topics: Adult; Aspartic Acid; Axons; Brain; Brain Chemistry; Choline; Creatine; Disease Progression; Female; | 2007 |
Axonal loss is progressive and partly dissociated from lesion load in early multiple sclerosis.
Topics: Adult; Aspartic Acid; Axons; Brain; Brain Chemistry; Choline; Creatine; Disease Progression; Female; | 2007 |
Axonal loss is progressive and partly dissociated from lesion load in early multiple sclerosis.
Topics: Adult; Aspartic Acid; Axons; Brain; Brain Chemistry; Choline; Creatine; Disease Progression; Female; | 2007 |
Axonal loss is progressive and partly dissociated from lesion load in early multiple sclerosis.
Topics: Adult; Aspartic Acid; Axons; Brain; Brain Chemistry; Choline; Creatine; Disease Progression; Female; | 2007 |
Axonal loss is progressive and partly dissociated from lesion load in early multiple sclerosis.
Topics: Adult; Aspartic Acid; Axons; Brain; Brain Chemistry; Choline; Creatine; Disease Progression; Female; | 2007 |
Axonal loss is progressive and partly dissociated from lesion load in early multiple sclerosis.
Topics: Adult; Aspartic Acid; Axons; Brain; Brain Chemistry; Choline; Creatine; Disease Progression; Female; | 2007 |
Axonal loss is progressive and partly dissociated from lesion load in early multiple sclerosis.
Topics: Adult; Aspartic Acid; Axons; Brain; Brain Chemistry; Choline; Creatine; Disease Progression; Female; | 2007 |
Axonal loss is progressive and partly dissociated from lesion load in early multiple sclerosis.
Topics: Adult; Aspartic Acid; Axons; Brain; Brain Chemistry; Choline; Creatine; Disease Progression; Female; | 2007 |
Axonal loss is progressive and partly dissociated from lesion load in early multiple sclerosis.
Topics: Adult; Aspartic Acid; Axons; Brain; Brain Chemistry; Choline; Creatine; Disease Progression; Female; | 2007 |
The basal ganglia: a substrate for fatigue in multiple sclerosis.
Topics: Adolescent; Adult; Aspartic Acid; Choline; Corpus Striatum; Creatine; Disability Evaluation; Energy | 2008 |
1H MRSI comparison of white matter and lesions in primary progressive and relapsing-remitting MS.
Topics: Adult; Aspartic Acid; Brain; Creatine; Female; Humans; Magnetic Resonance Imaging; Magnetic Resonanc | 2000 |
Volume correction for edema in single-volume proton MR spectroscopy of contrast-enhancing multiple sclerosis lesions.
Topics: Adult; Aspartic Acid; Brain; Case-Control Studies; Choline; Contrast Media; Creatine; Edema; Female; | 2001 |
[Proton magnetic-resonance spectroscopy in remitting and secondary-progressive multiple sclerosis].
Topics: Adolescent; Adult; Aspartic Acid; Brain; Choline; Creatine; Demyelinating Diseases; Female; gamma-Am | 2001 |