Page last updated: 2024-10-17

creatine and Acute Post-Traumatic Stress Disorder

creatine has been researched along with Acute Post-Traumatic Stress Disorder in 26 studies

Research Excerpts

ExcerptRelevanceReference
"Twenty-one veterans with PTSD and eight age-matched control veterans were studied using proton magnetic resonance spectroscopy to test the hypothesis that the N-acetyl-L-aspartic acid/creatine (NAA/Cr) ratio would be decreased in the right medial temporal lobe structures of patients with PTSD compared to controls."2.69In vivo proton magnetic resonance spectroscopy of the medial temporal lobes of subjects with combat-related posttraumatic stress disorder. ( Cardwell, D; Freeman, TW; Karson, CN; Komoroski, RA, 1998)
"Posttraumatic stress disorder (PTSD) is a trauma and stressor-related disorder that results in complex somatic, cognitive, affective and behavioural effects, after exposure to traumatic event(s)."2.58Systematic review of in-vivo neuro magnetic resonance spectroscopy for the assessment of posttraumatic stress disorder. ( Mountford, C; Quadrelli, S; Ramadan, S, 2018)
"The Clinician Administered PTSD Scale measured hyperarousal symptoms, including sleep disruption."1.72Regional specificity and clinical correlates of cortical GABA alterations in posttraumatic stress disorder. ( Eric Jensen, J; Olson, EA; Ren, B; Rosso, IM; Silveri, MM, 2022)
"Seventy-eight drug-naïve PTSD subjects and 71 non-PTSD age- and sex-matched control subjects were enrolled, all of whom had suffered the same earthquake about one year before."1.48Abnormal metabolite concentrations and amygdala volume in patients with recent-onset posttraumatic stress disorder. ( Gong, Q; Kemp, GJ; Li, L; Su, X; Sun, H; Tan, Q; Wang, W; Xia, C; Yue, Q; Zhang, S, 2018)
"Fluoxetine treatment corrected the SPS increases in the NAA/Cr and Cho/Cr levels in the amygdala on day 4 and in the hippocampus on day 14, but it failed to normalise SPS-associated decreases in NAA/Cr levels in the left hippocampus on day 1."1.42Effects of fluoxetine on the amygdala and the hippocampus after administration of a single prolonged stress to male Wistar rates: In vivo proton magnetic resonance spectroscopy findings. ( Han, F; Shi, Y; Wen, L; Xiao, B, 2015)
"Posttraumatic stress disorder (PTSD) patients have low cortical concentrations of γ-aminobutyric acid (GABA) and elevated glutamate (Glu) as measured by proton magnetic resonance spectroscopy ((1)H MRS)."1.40A preliminary examination of cortical neurotransmitter levels associated with heavy drinking in posttraumatic stress disorder. ( Abé, C; Batki, SL; Meyerhoff, DJ; Pennington, DL, 2014)
"The severity of PTSD was evaluated by the Clinician-Administered PTSD Scale (CAPS)."1.39More vulnerability of left than right hippocampal damage in right-handed patients with post-traumatic stress disorder. ( Chen, FY; Liu, W; Liu, ZC; Shu, XJ; Sun, XH; Wang, XP; Xue, L; Zhao, H; Zhu, C, 2013)
"Associative (freezing to trauma context) and nonassociative (freezing to a neutral tone; i."1.35Hippocampal N-acetylaspartate levels before trauma predict the development of long-lasting posttraumatic stress disorder-like symptoms in mice. ( Czisch, M; Holsboer, F; Kaltwasser, SF; Siegmund, A; Wotjak, CT, 2009)
"Co-morbidities of PTSD, notably alcohol abuse, may have contributed to the inconsistency."1.35Abnormal N-acetylaspartate in hippocampus and anterior cingulate in posttraumatic stress disorder. ( Fox-Bosetti, S; Kornak, J; Lenoci, M; Marmar, CR; Neylan, TC; Samuelson, KW; Schuff, N; Studholme, C; Weiner, MW, 2008)
"Intimate partner violence subjects with PTSD had significantly higher anterior cingulate Cho/Cr than intimate partner violence subjects without PTSD."1.33Single voxel proton magnetic resonance spectroscopy in women with and without intimate partner violence-related posttraumatic stress disorder. ( Kennedy, CM; Seedat, S; Stein, MB; Videen, JS, 2005)
"Eight patients with PTSD and 5 control subjects underwent single-voxel 1H-MRS of the hippocampi and bilateral OWM."1.31Proton magnetic resonance spectroscopy of the hippocampus and occipital white matter in PTSD: preliminary results. ( Brooks, WM; Griego, JA; Hamilton, DA; Hart, BL; Horan, WP; Moreshead, M; Petropoulos, H; Rowland, LM; Villarreal, G, 2002)

Research

Studies (26)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's1 (3.85)18.2507
2000's13 (50.00)29.6817
2010's11 (42.31)24.3611
2020's1 (3.85)2.80

Authors

AuthorsStudies
Rosso, IM1
Silveri, MM1
Olson, EA1
Eric Jensen, J1
Ren, B1
Harnett, NG1
Wood, KH1
Ference, EW1
Reid, MA1
Lahti, AC1
Knight, AJ1
Knight, DC1
Quadrelli, S1
Mountford, C1
Ramadan, S1
Su, X2
Xia, C2
Wang, W2
Sun, H2
Tan, Q2
Zhang, S2
Li, L2
Kemp, GJ2
Yue, Q2
Gong, Q2
Pennington, DL1
Abé, C1
Batki, SL1
Meyerhoff, DJ2
Han, F1
Xiao, B1
Wen, L1
Shi, Y1
Yang, ZY1
Quan, H1
Peng, ZL1
Zhong, Y1
Tan, ZJ1
Gong, QY1
Siegmund, A1
Kaltwasser, SF1
Holsboer, F1
Czisch, M1
Wotjak, CT1
Hoerst, M1
Weber-Fahr, W1
Tunc-Skarka, N1
Ruf, M1
Bohus, M1
Schmahl, C1
Ende, G1
Knox, D1
Perrine, SA1
George, SA1
Galloway, MP1
Liberzon, I1
Guo, M1
Chen, F1
Guo, JC1
Lu, CZ1
Jiang, XL1
Liu, T1
Li, M1
Song, W1
Shu, XJ1
Xue, L1
Liu, W1
Chen, FY1
Zhu, C1
Sun, XH1
Wang, XP1
Liu, ZC1
Zhao, H1
Villarreal, G1
Petropoulos, H1
Hamilton, DA1
Rowland, LM1
Horan, WP1
Griego, JA1
Moreshead, M1
Hart, BL1
Brooks, WM1
Mohanakrishnan Menon, P1
Nasrallah, HA1
Lyons, JA1
Scott, MF1
Liberto, V1
Brown, S1
Freeman, T1
Kimbrell, T1
Cardwell, D2
Komoroski, R1
Seedat, S1
Videen, JS1
Kennedy, CM1
Stein, MB1
Coplan, JD1
Mathew, SJ1
Mao, X1
Smith, EL1
Hof, PR1
Coplan, PM1
Rosenblum, LA1
Gorman, JM1
Shungu, DC1
Schuff, N3
Mueller, S1
Chao, L1
Sacrey, DT1
Laxer, K1
Weiner, MW3
Amital, D2
Vishne, T2
Roitman, S1
Kotler, M1
Levine, J2
Rubinow, A1
Neylan, TC2
Fox-Bosetti, S1
Lenoci, M1
Samuelson, KW1
Studholme, C1
Kornak, J1
Marmar, CR2
Freeman, TW1
Karson, CN1
Komoroski, RA1
De Bellis, MD2
Keshavan, MS2
Spencer, S1
Hall, J1
Harenski, KA1
Lenoci, MA1
Du, AT1
Weiss, DS1

Reviews

2 reviews available for creatine and Acute Post-Traumatic Stress Disorder

ArticleYear
Systematic review of in-vivo neuro magnetic resonance spectroscopy for the assessment of posttraumatic stress disorder.
    Psychiatry research. Neuroimaging, 2018, 12-30, Volume: 282

    Topics: Aspartic Acid; Atrophy; Brain; Creatine; Female; gamma-Aminobutyric Acid; Gyrus Cinguli; Hippocampus

2018
N-acetylaspartate as a marker of neuronal injury in neurodegenerative disease.
    Advances in experimental medicine and biology, 2006, Volume: 576

    Topics: Aging; Alcoholism; Amyotrophic Lateral Sclerosis; Aspartic Acid; Biomarkers; Brain; Brain Injuries;

2006

Trials

2 trials available for creatine and Acute Post-Traumatic Stress Disorder

ArticleYear
Open study of creatine monohydrate in treatment-resistant posttraumatic stress disorder.
    The Journal of clinical psychiatry, 2006, Volume: 67, Issue:5

    Topics: Adult; Comorbidity; Creatine; Depressive Disorder, Major; Diagnostic and Statistical Manual of Menta

2006
In vivo proton magnetic resonance spectroscopy of the medial temporal lobes of subjects with combat-related posttraumatic stress disorder.
    Magnetic resonance in medicine, 1998, Volume: 40, Issue:1

    Topics: Adult; Aspartic Acid; Creatine; Humans; Magnetic Resonance Spectroscopy; Male; Middle Aged; Protons;

1998

Other Studies

22 other studies available for creatine and Acute Post-Traumatic Stress Disorder

ArticleYear
Regional specificity and clinical correlates of cortical GABA alterations in posttraumatic stress disorder.
    Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2022, Volume: 47, Issue:5

    Topics: Adult; Brain; Creatine; Dissociative Disorders; gamma-Aminobutyric Acid; Humans; Magnetic Resonance

2022
Glutamate/glutamine concentrations in the dorsal anterior cingulate vary with Post-Traumatic Stress Disorder symptoms.
    Journal of psychiatric research, 2017, Volume: 91

    Topics: Adult; Creatine; Female; Glutamic Acid; Glutamine; Gyrus Cinguli; Humans; Intelligence Tests; Male;

2017
Abnormal metabolite concentrations and amygdala volume in patients with recent-onset posttraumatic stress disorder.
    Journal of affective disorders, 2018, 12-01, Volume: 241

    Topics: Adult; Amygdala; Aspartic Acid; Brain; Creatine; Female; Gyrus Cinguli; Humans; Inositol; Magnetic R

2018
Increased right amygdala metabolite concentrations in the absence of atrophy in children and adolescents with PTSD.
    European child & adolescent psychiatry, 2019, Volume: 28, Issue:6

    Topics: Adolescent; Amygdala; Aspartic Acid; Atrophy; Biomarkers; Child; Choline; Creatine; Cross-Sectional

2019
A preliminary examination of cortical neurotransmitter levels associated with heavy drinking in posttraumatic stress disorder.
    Psychiatry research, 2014, Dec-30, Volume: 224, Issue:3

    Topics: Adult; Aged; Alcoholism; Aspartic Acid; Cerebral Cortex; Choline; Comorbidity; Creatine; gamma-Amino

2014
Effects of fluoxetine on the amygdala and the hippocampus after administration of a single prolonged stress to male Wistar rates: In vivo proton magnetic resonance spectroscopy findings.
    Psychiatry research, 2015, May-30, Volume: 232, Issue:2

    Topics: Amygdala; Animals; Aspartic Acid; Choline; Creatine; Fluoxetine; Hippocampus; Male; Proton Magnetic

2015
Proton magnetic resonance spectroscopy revealed differences in the glutamate + glutamine/creatine ratio of the anterior cingulate cortex between healthy and pediatric post-traumatic stress disorder patients diagnosed after 2008 Wenchuan earthquake.
    Psychiatry and clinical neurosciences, 2015, Volume: 69, Issue:12

    Topics: Adolescent; Case-Control Studies; China; Creatine; Disasters; Earthquakes; Female; Glutamic Acid; Gl

2015
Hippocampal N-acetylaspartate levels before trauma predict the development of long-lasting posttraumatic stress disorder-like symptoms in mice.
    Biological psychiatry, 2009, Feb-01, Volume: 65, Issue:3

    Topics: Animals; Aspartic Acid; Behavior, Animal; Creatine; Data Interpretation, Statistical; Electroshock;

2009
Metabolic alterations in the amygdala in borderline personality disorder: a proton magnetic resonance spectroscopy study.
    Biological psychiatry, 2010, Mar-01, Volume: 67, Issue:5

    Topics: Adult; Amygdala; Aspartic Acid; Borderline Personality Disorder; Creatine; Female; Functional Latera

2010
Single prolonged stress decreases glutamate, glutamine, and creatine concentrations in the rat medial prefrontal cortex.
    Neuroscience letters, 2010, Aug-09, Volume: 480, Issue:1

    Topics: Amygdala; Animals; Aspartic Acid; Creatine; Energy Metabolism; gamma-Aminobutyric Acid; Glutamic Aci

2010
Study of the hippocampus and the anterior cingulate gyrus by proton MR spectroscopy in patients with post-traumatic stress disorder.
    Asian Pacific journal of tropical medicine, 2012, Volume: 5, Issue:2

    Topics: Adolescent; Adult; Aspartic Acid; China; Choline; Creatine; Female; Gyrus Cinguli; Hippocampus; Huma

2012
More vulnerability of left than right hippocampal damage in right-handed patients with post-traumatic stress disorder.
    Psychiatry research, 2013, Jun-30, Volume: 212, Issue:3

    Topics: Adolescent; Adult; Case-Control Studies; Choline; Creatine; Female; Functional Laterality; Hippocamp

2013
Proton magnetic resonance spectroscopy of the hippocampus and occipital white matter in PTSD: preliminary results.
    Canadian journal of psychiatry. Revue canadienne de psychiatrie, 2002, Volume: 47, Issue:7

    Topics: Adult; Aspartic Acid; Choline; Creatine; Dominance, Cerebral; Energy Metabolism; Female; Hippocampus

2002
Single-voxel proton MR spectroscopy of right versus left hippocampi in PTSD.
    Psychiatry research, 2003, Jun-30, Volume: 123, Issue:2

    Topics: Adult; Aged; Aspartic Acid; Cell Survival; Choline; Combat Disorders; Creatine; Dominance, Cerebral;

2003
In vivo proton magnetic resonance spectroscopy of the medial temporal lobes of former prisoners of war with and without posttraumatic stress disorder.
    The Journal of neuropsychiatry and clinical neurosciences, 2003,Summer, Volume: 15, Issue:3

    Topics: Aged; Aged, 80 and over; Aspartic Acid; Choline; Creatine; Humans; Magnetic Resonance Spectroscopy;

2003
Single voxel proton magnetic resonance spectroscopy in women with and without intimate partner violence-related posttraumatic stress disorder.
    Psychiatry research, 2005, Aug-30, Volume: 139, Issue:3

    Topics: Adult; Aspartic Acid; Brain; Choline; Conflict, Psychological; Creatine; Diagnostic and Statistical

2005
Decreased choline and creatine concentrations in centrum semiovale in patients with generalized anxiety disorder: relationship to IQ and early trauma.
    Psychiatry research, 2006, Jun-30, Volume: 147, Issue:1

    Topics: Adult; Anxiety Disorders; Body Mass Index; Choline; Cognition Disorders; Creatine; Frontal Lobe; Fun

2006
Observed effects of creatine monohydrate in a patient with depression and fibromyalgia.
    The American journal of psychiatry, 2006, Volume: 163, Issue:10

    Topics: Comorbidity; Creatine; Depressive Disorder; Drug Therapy, Combination; Female; Fibromyalgia; Humans;

2006
Abnormal N-acetylaspartate in hippocampus and anterior cingulate in posttraumatic stress disorder.
    Psychiatry research, 2008, Feb-28, Volume: 162, Issue:2

    Topics: Adult; Alcoholism; Algorithms; Aspartic Acid; Atrophy; Combat Disorders; Comorbidity; Conditioning,

2008
N-Acetylaspartate concentration in the anterior cingulate of maltreated children and adolescents with PTSD.
    The American journal of psychiatry, 2000, Volume: 157, Issue:7

    Topics: Adolescent; Aspartic Acid; Child; Child Abuse; Creatine; Gyrus Cinguli; Humans; Stress Disorders, Po

2000
Anterior cingulate N-acetylaspartate/creatine ratios during clonidine treatment in a maltreated child with posttraumatic stress disorder.
    Journal of child and adolescent psychopharmacology, 2001,Fall, Volume: 11, Issue:3

    Topics: Adrenergic alpha-Agonists; Aspartic Acid; Child; Child Abuse; Clonidine; Creatine; Gyrus Cinguli; Hu

2001
Decreased hippocampal N-acetylaspartate in the absence of atrophy in posttraumatic stress disorder.
    Biological psychiatry, 2001, Dec-15, Volume: 50, Issue:12

    Topics: Aspartic Acid; Atrophy; Brain; Case-Control Studies; Creatine; Hippocampus; Humans; Magnetic Resonan

2001