creatine has been researched along with Acquired-Immune Deficiency Syndrome Dementia Complex in 37 studies
| Excerpt | Relevance | Reference |
|---|---|---|
| " By contrast, a significant elevation in compounds containing choline was present in patients in the early stages of HIV infection of who had CD4 counts greater than 200/microliter, in patients with normal MRI scans, and in all AIDS dementia complex groups, including subjects with no or minimal cognitive impairment." | 7.69 | Brain choline-containing compounds are elevated in HIV-positive patients before the onset of AIDS dementia complex: A proton magnetic resonance spectroscopic study. ( Carr, CA; González, RG; Guimaraes, AR; Navia, BA; Tracey, I; Worth, JL, 1996) |
| "To demonstrate the technical feasibility and reliability of a multi-center study characterizing regional levels of the brain metabolite ratios choline (Cho)/creatine (Cr) and myoinositol (MI)/Cr, markers of glial cell activity, and N-acetyl aspartate (NAA)/Cr, a marker of mature neurons, in subjects with AIDS dementia complex (ADC)." | 5.10 | A multi-center 1H MRS study of the AIDS dementia complex: validation and preliminary analysis. ( Chang, L; Ernst, T; Gonzalez, RG; Jarvik, JG; Ketonen, LM; Kolson, DL; Kwok, EW; Lee, PL; Lenkinski, RE; Marra, CM; Meyerhoff, DJ; Navia, BA; Richards, TL; Schifitto, G; Simpson, D; Tang, CY; Yiannoutsos, CT, 2003) |
| " By contrast, a significant elevation in compounds containing choline was present in patients in the early stages of HIV infection of who had CD4 counts greater than 200/microliter, in patients with normal MRI scans, and in all AIDS dementia complex groups, including subjects with no or minimal cognitive impairment." | 3.69 | Brain choline-containing compounds are elevated in HIV-positive patients before the onset of AIDS dementia complex: A proton magnetic resonance spectroscopic study. ( Carr, CA; González, RG; Guimaraes, AR; Navia, BA; Tracey, I; Worth, JL, 1996) |
| "Patients with AIDS had more signs of neurological dysfunction, poorer performance on a neuropsychological test battery, were more likely to have an abnormal EEG, and to have abnormalities on MRI." | 1.30 | Evidence of CNS impairment in HIV infection: clinical, neuropsychological, EEG, and MRI/MRS study. ( Carter, S; Fowler, CJ; Hall-Craggs, MA; Harrison, MJ; Kendall, BE; Lunn, S; Miller, R; Newman, SP; Paley, M; Sweeney, B; Wilkinson, I; Williams, I, 1998) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 14 (37.84) | 18.2507 |
| 2000's | 14 (37.84) | 29.6817 |
| 2010's | 9 (24.32) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Alakkas, A | 1 |
| Ellis, RJ | 2 |
| Watson, CW | 1 |
| Umlauf, A | 1 |
| Heaton, RK | 1 |
| Letendre, S | 1 |
| Collier, A | 1 |
| Marra, C | 1 |
| Clifford, DB | 1 |
| Gelman, B | 1 |
| Sacktor, N | 2 |
| Morgello, S | 1 |
| Simpson, D | 2 |
| McCutchan, JA | 1 |
| Kallianpur, A | 1 |
| Gianella, S | 1 |
| Marcotte, T | 1 |
| Grant, I | 1 |
| Fennema-Notestine, C | 1 |
| Harezlak, J | 1 |
| Cohen, R | 1 |
| Gongvatana, A | 1 |
| Taylor, M | 1 |
| Buchthal, S | 2 |
| Schifitto, G | 4 |
| Zhong, J | 1 |
| Daar, ES | 1 |
| Alger, JR | 1 |
| Brown, M | 1 |
| Singer, EJ | 1 |
| Campbell, TB | 1 |
| McMahon, D | 1 |
| So, YT | 1 |
| Yiannoutsos, CT | 5 |
| Navia, BA | 5 |
| Van Dalen, YW | 1 |
| Blokhuis, C | 1 |
| Cohen, S | 1 |
| Ter Stege, JA | 1 |
| Teunissen, CE | 1 |
| Kuhle, J | 1 |
| Kootstra, NA | 1 |
| Scherpbier, HJ | 1 |
| Kuijpers, TW | 1 |
| Reiss, P | 1 |
| Majoie, CBLM | 1 |
| Caan, MWA | 1 |
| Pajkrt, D | 1 |
| Iqbal, Z | 1 |
| Wilson, NE | 1 |
| Keller, MA | 1 |
| Michalik, DE | 1 |
| Church, JA | 1 |
| Nielsen-Saines, K | 1 |
| Deville, J | 1 |
| Souza, R | 1 |
| Brecht, ML | 1 |
| Thomas, MA | 1 |
| Boban, J | 1 |
| Kozic, D | 1 |
| Turkulov, V | 1 |
| Ostojic, J | 1 |
| Semnic, R | 1 |
| Lendak, D | 1 |
| Brkic, S | 1 |
| Mohamed, MA | 1 |
| Lentz, MR | 4 |
| Lee, V | 2 |
| Halpern, EF | 2 |
| Selnes, O | 1 |
| Barker, PB | 1 |
| Pomper, MG | 1 |
| Winston, A | 2 |
| Duncombe, C | 2 |
| Li, PC | 2 |
| Gill, JM | 2 |
| Kerr, SJ | 2 |
| Puls, R | 1 |
| Petoumenos, K | 1 |
| Taylor-Robinson, SD | 2 |
| Emery, S | 2 |
| Cooper, DA | 2 |
| Nakas, CT | 1 |
| Alonzo, TA | 1 |
| Puls, RL | 1 |
| Chang, L | 7 |
| Ernst, T | 8 |
| Witt, MD | 1 |
| Ames, N | 1 |
| Gaiefsky, M | 1 |
| Miller, E | 1 |
| Hurley, RA | 1 |
| Khalili, K | 1 |
| Del Valle, L | 1 |
| Simone, IL | 2 |
| Taber, KH | 1 |
| Lee, PL | 2 |
| Marra, CM | 3 |
| Jarvik, JG | 2 |
| Richards, TL | 1 |
| Kwok, EW | 1 |
| Kolson, DL | 2 |
| Tang, CY | 1 |
| Ketonen, LM | 1 |
| Meyerhoff, DJ | 3 |
| Lenkinski, RE | 3 |
| Gonzalez, RG | 5 |
| Arnold, S | 1 |
| Fuller, RA | 1 |
| Westmoreland, SV | 3 |
| Ratai, E | 1 |
| Greco, JB | 2 |
| Kim, JP | 1 |
| He, J | 2 |
| Sehgal, PK | 2 |
| Masliah, E | 2 |
| Halpern, E | 1 |
| Lackner, AA | 2 |
| Ratai, EM | 2 |
| Sakaie, K | 1 |
| St Hillaire, C | 1 |
| Conant, K | 1 |
| Richards, T | 2 |
| Kolson, D | 2 |
| Miller, EN | 2 |
| Lenkinski, R | 1 |
| Gonzalez, G | 2 |
| Nelson, JA | 1 |
| Dou, H | 1 |
| Ellison, B | 1 |
| Uberti, M | 1 |
| Xiong, H | 1 |
| Anderson, E | 1 |
| Mellon, M | 1 |
| Gelbard, HA | 1 |
| Boska, M | 1 |
| Gendelman, HE | 2 |
| Tarasów, E | 1 |
| Wiercińska-Drapało, A | 1 |
| Jaroszewicz, J | 1 |
| Orzechowska-Bobkiewicz, A | 1 |
| Dzienis, W | 1 |
| Prokopowicz, D | 1 |
| Walecki, J | 1 |
| Roc, AC | 1 |
| Ances, BM | 1 |
| Chawla, S | 1 |
| Korczykowski, M | 1 |
| Wolf, RL | 1 |
| Detre, JA | 1 |
| Poptani, H | 1 |
| Paul, RH | 1 |
| Singer, E | 1 |
| Jarvik, GJ | 1 |
| Price, R | 1 |
| Cohen, RA | 1 |
| Miller, BL | 1 |
| McBride, D | 1 |
| Cornford, M | 1 |
| Oropilla, G | 1 |
| Chiang, F | 1 |
| Aronow, H | 1 |
| Beck, CK | 1 |
| McConnell, JR | 1 |
| Swindells, S | 1 |
| Ong, CS | 1 |
| Gmeiner, WH | 1 |
| Chu, WK | 1 |
| Brown, DK | 1 |
| Vion-Dury, J | 3 |
| Confort-Gouny, S | 3 |
| Nicoli, F | 2 |
| Dhiver, C | 1 |
| Gastaut, JA | 1 |
| Gastaut, JL | 1 |
| Cozzone, PJ | 3 |
| Chong, WK | 1 |
| Paley, M | 2 |
| Wilkinson, ID | 1 |
| Hall-Craggs, MA | 2 |
| Sweeney, B | 2 |
| Harrison, MJ | 2 |
| Miller, RF | 1 |
| Kendall, BE | 2 |
| Tracey, I | 1 |
| Carr, CA | 1 |
| Guimaraes, AR | 1 |
| Worth, JL | 1 |
| Lu, D | 2 |
| Pavlakis, SG | 2 |
| Frank, Y | 2 |
| Bakshi, S | 1 |
| Pahwa, S | 1 |
| Gould, RJ | 1 |
| Sison, C | 1 |
| Hsu, C | 1 |
| Lesser, M | 1 |
| Hoberman, M | 1 |
| Barnett, T | 2 |
| Hyman, RA | 2 |
| Weiner, MW | 1 |
| Fein, G | 1 |
| Salvan, AM | 2 |
| Lamoureux, S | 1 |
| López-Villegas, D | 1 |
| Frank, I | 1 |
| Wiznia, A | 1 |
| Eidelberg, D | 1 |
| Federico, F | 1 |
| Tortorella, C | 1 |
| Andreula, CF | 1 |
| Zimatore, GB | 1 |
| Giannini, P | 1 |
| Angarano, G | 1 |
| Lucivero, V | 1 |
| Picciola, P | 1 |
| Carrara, D | 1 |
| Bellacosa, A | 1 |
| Livrea, P | 1 |
| Laubenberger, J | 1 |
| Bayer, S | 1 |
| Thiel, T | 1 |
| Hennig, J | 1 |
| Langer, M | 1 |
| Newman, SP | 1 |
| Fowler, CJ | 1 |
| Miller, R | 1 |
| Wilkinson, I | 1 |
| Lunn, S | 1 |
| Carter, S | 1 |
| Williams, I | 1 |
| von Giesen, HJ | 1 |
| Wittsack, HJ | 1 |
| Wenserski, F | 1 |
| Köller, H | 1 |
| Hefter, H | 1 |
| Arendt, G | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A Randomised, Open-label, 96-week Study Comparing the Safety and Efficacy of Three Different Combination Antiretroviral Regimens as Initial Therapy for HIV Infection.[NCT00335322] | Phase 4 | 329 participants (Actual) | Interventional | 2007-02-28 | Completed | ||
| A Cognitive Rehabilitation Program to Promote Treatment Adherence for Individuals Who Are HIV Positive With Mild Neurocognitive Difficulties[NCT02392884] | 60 participants (Anticipated) | Interventional | 2014-09-30 | Recruiting | |||
| Adaptive Working Memory and Physical Exercise Training to Improve Brain and Mitochondrial Function in MCI[NCT05948930] | 90 participants (Anticipated) | Interventional | 2024-01-31 | Not yet recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
(NCT00335322)
Timeframe: 144 weeks
| Intervention | log copies/mL (Mean) |
|---|---|
| TDF/FTC+EFV | -2.77 |
| TDF/FTC+ r/ATV | -2.88 |
| TDF/FTC + AZT+ABC | -2.54 |
(NCT00335322)
Timeframe: 48 weeks
| Intervention | log copies/mL (Mean) |
|---|---|
| TDF/FTC+EFV | -2.59 |
| TDF/FTC+r/ATV | -2.69 |
| TDF/FTC+AZT+ABC | -2.39 |
5 trials available for creatine and Acquired-Immune Deficiency Syndrome Dementia Complex
| Article | Year |
|---|---|
Does choice of combination antiretroviral therapy (cART) alter changes in cerebral function testing after 48 weeks in treatment-naive, HIV-1-infected individuals commencing cART? A randomized, controlled study.
Topics: AIDS Dementia Complex; Anti-HIV Agents; Antiretroviral Therapy, Highly Active; Aspartic Acid; Brain | 2010 |
A multi-center 1H MRS study of the AIDS dementia complex: validation and preliminary analysis.
Topics: AIDS Dementia Complex; Analysis of Variance; Aspartic Acid; Brain; Choline; Creatine; Excitatory Ami | 2003 |
Antiretroviral treatment alters relationship between MCP-1 and neurometabolites in HIV patients.
Topics: Adult; AIDS Dementia Complex; Anti-HIV Agents; Antiretroviral Therapy, Highly Active; Brain; Brain C | 2004 |
A multicenter in vivo proton-MRS study of HIV-associated dementia and its relationship to age.
Topics: Adult; Age Factors; AIDS Dementia Complex; Anti-HIV Agents; Aspartic Acid; Basal Ganglia; Brain; Bra | 2004 |
Proton MRS and neuropsychological correlates in AIDS dementia complex: evidence of subcortical specificity.
Topics: AIDS Dementia Complex; Antiparkinson Agents; Aspartic Acid; Basal Ganglia; Creatine; Female; Humans; | 2007 |
32 other studies available for creatine and Acquired-Immune Deficiency Syndrome Dementia Complex
| Article | Year |
|---|---|
White matter damage, neuroinflammation, and neuronal integrity in HAND.
Topics: Adult; AIDS Dementia Complex; Anti-HIV Agents; Antiretroviral Therapy, Highly Active; Aspartic Acid; | 2019 |
Predictors of CNS injury as measured by proton magnetic resonance spectroscopy in the setting of chronic HIV infection and CART.
Topics: Adult; AIDS Dementia Complex; Anti-Retroviral Agents; Aspartic Acid; Basal Ganglia; Choline; Chronic | 2014 |
Neurometabolite Alterations Associated With Cognitive Performance in Perinatally HIV-Infected Children.
Topics: Adolescent; AIDS Dementia Complex; Aspartic Acid; Brain; CD4 Lymphocyte Count; Child; Choline; Cogni | 2016 |
Pilot Assessment of Brain Metabolism in Perinatally HIV-Infected Youths Using Accelerated 5D Echo Planar J-Resolved Spectroscopic Imaging.
Topics: Adolescent; AIDS Dementia Complex; Algorithms; Anti-HIV Agents; Aspartic Acid; Brain; Case-Control S | 2016 |
HIV-associated neurodegeneration and neuroimmunity: multivoxel MR spectroscopy study in drug-naïve and treated patients.
Topics: Adult; AIDS Dementia Complex; Aspartic Acid; Biomarkers; Brain; Case-Control Studies; Choline; Creat | 2017 |
Factor analysis of proton MR spectroscopic imaging data in HIV infection: metabolite-derived factors help identify infection and dementia.
Topics: Adult; AIDS Dementia Complex; Analysis of Variance; Aspartic Acid; Case-Control Studies; Chi-Square | 2010 |
Accuracy and cut-off point selection in three-class classification problems using a generalization of the Youden index.
Topics: AIDS Dementia Complex; Aspartic Acid; Bias; Biomarkers; Biostatistics; Classification; Computer Simu | 2010 |
Two patterns of cerebral metabolite abnormalities are detected on proton magnetic resonance spectroscopy in HIV-infected subjects commencing antiretroviral therapy.
Topics: Adult; AIDS Dementia Complex; Anti-HIV Agents; Antiretroviral Therapy, Highly Active; Aspartic Acid; | 2012 |
Relationships among brain metabolites, cognitive function, and viral loads in antiretroviral-naïve HIV patients.
Topics: Adult; AIDS Dementia Complex; Aspartic Acid; Basal Ganglia; Brain; CD4 Lymphocyte Count; Cerebral Co | 2002 |
Identification of HIV-associated progressive multifocal leukoencephalopathy: magnetic resonance imaging and spectroscopy.
Topics: AIDS Dementia Complex; AIDS-Related Opportunistic Infections; Aspartic Acid; Astrocytes; Brain; Chol | 2003 |
Increased glial metabolites predict increased working memory network activation in HIV brain injury.
Topics: Adult; AIDS Dementia Complex; Attention; Basal Ganglia; Brain Mapping; Choline; Creatine; Frontal Lo | 2003 |
A prospective longitudinal in vivo 1H MR spectroscopy study of the SIV/macaque model of neuroAIDS.
Topics: Acute Disease; AIDS Dementia Complex; Animals; Aspartic Acid; Brain; Choline; Chronic Disease; Creat | 2004 |
In vivo 1H MRS of brain injury and repair during acute SIV infection in the macaque model of neuroAIDS.
Topics: Acute Disease; AIDS Dementia Complex; Animals; Aspartic Acid; Brain; Choline; Creatine; Female; Fron | 2004 |
Coregistration of quantitative proton magnetic resonance spectroscopic imaging with neuropathological and neurophysiological analyses defines the extent of neuronal impairments in murine human immunodeficiency virus type-1 encephalitis.
Topics: AIDS Dementia Complex; Animals; Aspartic Acid; Brain Mapping; Calcium-Binding Proteins; Capsid Prote | 2005 |
Antiretroviral therapy and its influence on the stage of brain damage in patients with HIV - 1H MRS evaluation.
Topics: Adult; AIDS Dementia Complex; Antiretroviral Therapy, Highly Active; Aspartic Acid; Brain; Choline; | 2004 |
Detection of human immunodeficiency virus induced inflammation and oxidative stress in lenticular nuclei with magnetic resonance spectroscopy despite antiretroviral therapy.
Topics: Adult; AIDS Dementia Complex; Antiretroviral Therapy, Highly Active; Aspartic Acid; Atrophy; Biomark | 2007 |
Metabolic markers of neuronal injury correlate with SIV CNS disease severity and inoculum in the macaque model of neuroAIDS.
Topics: AIDS Dementia Complex; Analysis of Variance; Animals; Aspartic Acid; Choline; Creatine; Disease Mode | 2008 |
Brain lesions in patients with AIDS: H-1 MR spectroscopy.
Topics: Abscess; Adult; AIDS Dementia Complex; Aspartic Acid; Brain Diseases; Brain Neoplasms; Choline; Crea | 1995 |
Prospective utility of cerebral proton magnetic resonance spectroscopy in monitoring HIV infection and its associated neurological impairment.
Topics: Adult; AIDS Dementia Complex; Aspartic Acid; Biomarkers; Child; Choline; Creatine; Humans; Magnetic | 1994 |
Localized brain proton MRS metabolic patterns in HIV-related encephalopathies.
Topics: AIDS Dementia Complex; Aspartic Acid; Brain; Choline; Creatine; HIV Infections; Humans; Magnetic Res | 1994 |
Localized cerebral proton MR spectroscopy in HIV infection and AIDS.
Topics: Acquired Immunodeficiency Syndrome; Adult; AIDS Dementia Complex; AIDS-Related Complex; Aspartic Aci | 1994 |
Brain choline-containing compounds are elevated in HIV-positive patients before the onset of AIDS dementia complex: A proton magnetic resonance spectroscopic study.
Topics: Adult; AIDS Dementia Complex; Aspartic Acid; Brain; Choline; Creatine; Female; HIV Seropositivity; H | 1996 |
Proton MR spectroscopy of the basal ganglia in healthy children and children with AIDS.
Topics: AIDS Dementia Complex; Aspartic Acid; Basal Ganglia; Brain Chemistry; Case-Control Studies; CD4 Lymp | 1996 |
Deep gray matter structures in HIV infection: a proton MR spectroscopic study.
Topics: Adult; AIDS Dementia Complex; Aspartic Acid; Basal Ganglia; Brain; Cerebral Ventricles; Choline; Cor | 1996 |
Cerebral metabolic alterations in human immunodeficiency virus-related encephalopathy detected by proton magnetic resonance spectroscopy. Comparison between sequences using short and long echo times.
Topics: Adult; Aged; AIDS Dementia Complex; Aspartic Acid; Brain; CD4 Lymphocyte Count; Choline; Creatine; F | 1997 |
Biochemical changes in the frontal lobe of HIV-infected individuals detected by magnetic resonance spectroscopy.
Topics: Adult; AIDS Dementia Complex; Brain Chemistry; Creatine; Female; Frontal Lobe; HIV Infections; HIV-1 | 1997 |
Brain lactate and N-acetylaspartate in pediatric AIDS encephalopathy.
Topics: AIDS Dementia Complex; Anti-HIV Agents; Aspartic Acid; Brain; Child; Child, Preschool; Creatine; Did | 1998 |
Localised 1H-MR spectroscopy for metabolic characterisation of diffuse and focal brain lesions in patients infected with HIV.
Topics: Adolescent; Adult; AIDS Dementia Complex; Aspartic Acid; Case-Control Studies; Choline; Creatine; Di | 1998 |
[Clinical uses of proton magnetic resonance spectroscopy of the brain].
Topics: AIDS Dementia Complex; Alzheimer Disease; Animals; Aspartic Acid; Brain; Brain Diseases; Brain Disea | 1998 |
Evidence of CNS impairment in HIV infection: clinical, neuropsychological, EEG, and MRI/MRS study.
Topics: Acquired Immunodeficiency Syndrome; Adult; AIDS Dementia Complex; Aspartic Acid; Atrophy; Brain; CD4 | 1998 |
[Brain proton magnetic resonance spectroscopy. Indications for diagnosis and follow-up of HIV-related encephalopathy in the adult].
Topics: AIDS Dementia Complex; Aspartic Acid; Brain; Choline; Creatine; Energy Metabolism; Humans; Magnetic | 1998 |
Basal ganglia metabolite abnormalities in minor motor disorders associated with human immunodeficiency virus type 1.
Topics: Adult; AIDS Dementia Complex; Aspartic Acid; Basal Ganglia; Choline; Creatine; Electrophysiology; HI | 2001 |