creatine has been researched along with AIDS Dementia Complex in 37 studies
AIDS Dementia Complex: A neurologic condition associated with the ACQUIRED IMMUNODEFICIENCY SYNDROME and characterized by impaired concentration and memory, slowness of hand movements, ATAXIA, incontinence, apathy, and gait difficulties associated with HIV-1 viral infection of the central nervous system. Pathologic examination of the brain reveals white matter rarefaction, perivascular infiltrates of lymphocytes, foamy macrophages, and multinucleated giant cells. (From Adams et al., Principles of Neurology, 6th ed, pp760-1; N Engl J Med, 1995 Apr 6;332(14):934-40)
| Excerpt | Relevance | Reference |
|---|---|---|
| " By contrast, a significant elevation in compounds containing choline was present in patients in the early stages of HIV infection of who had CD4 counts greater than 200/microliter, in patients with normal MRI scans, and in all AIDS dementia complex groups, including subjects with no or minimal cognitive impairment." | 7.69 | Brain choline-containing compounds are elevated in HIV-positive patients before the onset of AIDS dementia complex: A proton magnetic resonance spectroscopic study. ( Carr, CA; González, RG; Guimaraes, AR; Navia, BA; Tracey, I; Worth, JL, 1996) |
| "To demonstrate the technical feasibility and reliability of a multi-center study characterizing regional levels of the brain metabolite ratios choline (Cho)/creatine (Cr) and myoinositol (MI)/Cr, markers of glial cell activity, and N-acetyl aspartate (NAA)/Cr, a marker of mature neurons, in subjects with AIDS dementia complex (ADC)." | 5.10 | A multi-center 1H MRS study of the AIDS dementia complex: validation and preliminary analysis. ( Chang, L; Ernst, T; Gonzalez, RG; Jarvik, JG; Ketonen, LM; Kolson, DL; Kwok, EW; Lee, PL; Lenkinski, RE; Marra, CM; Meyerhoff, DJ; Navia, BA; Richards, TL; Schifitto, G; Simpson, D; Tang, CY; Yiannoutsos, CT, 2003) |
| " By contrast, a significant elevation in compounds containing choline was present in patients in the early stages of HIV infection of who had CD4 counts greater than 200/microliter, in patients with normal MRI scans, and in all AIDS dementia complex groups, including subjects with no or minimal cognitive impairment." | 3.69 | Brain choline-containing compounds are elevated in HIV-positive patients before the onset of AIDS dementia complex: A proton magnetic resonance spectroscopic study. ( Carr, CA; González, RG; Guimaraes, AR; Navia, BA; Tracey, I; Worth, JL, 1996) |
| "Patients with AIDS had more signs of neurological dysfunction, poorer performance on a neuropsychological test battery, were more likely to have an abnormal EEG, and to have abnormalities on MRI." | 1.30 | Evidence of CNS impairment in HIV infection: clinical, neuropsychological, EEG, and MRI/MRS study. ( Carter, S; Fowler, CJ; Hall-Craggs, MA; Harrison, MJ; Kendall, BE; Lunn, S; Miller, R; Newman, SP; Paley, M; Sweeney, B; Wilkinson, I; Williams, I, 1998) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 14 (37.84) | 18.2507 |
| 2000's | 14 (37.84) | 29.6817 |
| 2010's | 9 (24.32) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Alakkas, A | 1 |
| Ellis, RJ | 2 |
| Watson, CW | 1 |
| Umlauf, A | 1 |
| Heaton, RK | 1 |
| Letendre, S | 1 |
| Collier, A | 1 |
| Marra, C | 1 |
| Clifford, DB | 1 |
| Gelman, B | 1 |
| Sacktor, N | 2 |
| Morgello, S | 1 |
| Simpson, D | 2 |
| McCutchan, JA | 1 |
| Kallianpur, A | 1 |
| Gianella, S | 1 |
| Marcotte, T | 1 |
| Grant, I | 1 |
| Fennema-Notestine, C | 1 |
| Harezlak, J | 1 |
| Cohen, R | 1 |
| Gongvatana, A | 1 |
| Taylor, M | 1 |
| Buchthal, S | 2 |
| Schifitto, G | 4 |
| Zhong, J | 1 |
| Daar, ES | 1 |
| Alger, JR | 1 |
| Brown, M | 1 |
| Singer, EJ | 1 |
| Campbell, TB | 1 |
| McMahon, D | 1 |
| So, YT | 1 |
| Yiannoutsos, CT | 5 |
| Navia, BA | 5 |
| Van Dalen, YW | 1 |
| Blokhuis, C | 1 |
| Cohen, S | 1 |
| Ter Stege, JA | 1 |
| Teunissen, CE | 1 |
| Kuhle, J | 1 |
| Kootstra, NA | 1 |
| Scherpbier, HJ | 1 |
| Kuijpers, TW | 1 |
| Reiss, P | 1 |
| Majoie, CBLM | 1 |
| Caan, MWA | 1 |
| Pajkrt, D | 1 |
| Iqbal, Z | 1 |
| Wilson, NE | 1 |
| Keller, MA | 1 |
| Michalik, DE | 1 |
| Church, JA | 1 |
| Nielsen-Saines, K | 1 |
| Deville, J | 1 |
| Souza, R | 1 |
| Brecht, ML | 1 |
| Thomas, MA | 1 |
| Boban, J | 1 |
| Kozic, D | 1 |
| Turkulov, V | 1 |
| Ostojic, J | 1 |
| Semnic, R | 1 |
| Lendak, D | 1 |
| Brkic, S | 1 |
| Mohamed, MA | 1 |
| Lentz, MR | 4 |
| Lee, V | 2 |
| Halpern, EF | 2 |
| Selnes, O | 1 |
| Barker, PB | 1 |
| Pomper, MG | 1 |
| Winston, A | 2 |
| Duncombe, C | 2 |
| Li, PC | 2 |
| Gill, JM | 2 |
| Kerr, SJ | 2 |
| Puls, R | 1 |
| Petoumenos, K | 1 |
| Taylor-Robinson, SD | 2 |
| Emery, S | 2 |
| Cooper, DA | 2 |
| Nakas, CT | 1 |
| Alonzo, TA | 1 |
| Puls, RL | 1 |
| Chang, L | 7 |
| Ernst, T | 8 |
| Witt, MD | 1 |
| Ames, N | 1 |
| Gaiefsky, M | 1 |
| Miller, E | 1 |
| Hurley, RA | 1 |
| Khalili, K | 1 |
| Del Valle, L | 1 |
| Simone, IL | 2 |
| Taber, KH | 1 |
| Lee, PL | 2 |
| Marra, CM | 3 |
| Jarvik, JG | 2 |
| Richards, TL | 1 |
| Kwok, EW | 1 |
| Kolson, DL | 2 |
| Tang, CY | 1 |
| Ketonen, LM | 1 |
| Meyerhoff, DJ | 3 |
| Lenkinski, RE | 3 |
| Gonzalez, RG | 5 |
| Arnold, S | 1 |
| Fuller, RA | 1 |
| Westmoreland, SV | 3 |
| Ratai, E | 1 |
| Greco, JB | 2 |
| Kim, JP | 1 |
| He, J | 2 |
| Sehgal, PK | 2 |
| Masliah, E | 2 |
| Halpern, E | 1 |
| Lackner, AA | 2 |
| Ratai, EM | 2 |
| Sakaie, K | 1 |
| St Hillaire, C | 1 |
| Conant, K | 1 |
| Richards, T | 2 |
| Kolson, D | 2 |
| Miller, EN | 2 |
| Lenkinski, R | 1 |
| Gonzalez, G | 2 |
| Nelson, JA | 1 |
| Dou, H | 1 |
| Ellison, B | 1 |
| Uberti, M | 1 |
| Xiong, H | 1 |
| Anderson, E | 1 |
| Mellon, M | 1 |
| Gelbard, HA | 1 |
| Boska, M | 1 |
| Gendelman, HE | 2 |
| Tarasów, E | 1 |
| Wiercińska-Drapało, A | 1 |
| Jaroszewicz, J | 1 |
| Orzechowska-Bobkiewicz, A | 1 |
| Dzienis, W | 1 |
| Prokopowicz, D | 1 |
| Walecki, J | 1 |
| Roc, AC | 1 |
| Ances, BM | 1 |
| Chawla, S | 1 |
| Korczykowski, M | 1 |
| Wolf, RL | 1 |
| Detre, JA | 1 |
| Poptani, H | 1 |
| Paul, RH | 1 |
| Singer, E | 1 |
| Jarvik, GJ | 1 |
| Price, R | 1 |
| Cohen, RA | 1 |
| Miller, BL | 1 |
| McBride, D | 1 |
| Cornford, M | 1 |
| Oropilla, G | 1 |
| Chiang, F | 1 |
| Aronow, H | 1 |
| Beck, CK | 1 |
| McConnell, JR | 1 |
| Swindells, S | 1 |
| Ong, CS | 1 |
| Gmeiner, WH | 1 |
| Chu, WK | 1 |
| Brown, DK | 1 |
| Vion-Dury, J | 3 |
| Confort-Gouny, S | 3 |
| Nicoli, F | 2 |
| Dhiver, C | 1 |
| Gastaut, JA | 1 |
| Gastaut, JL | 1 |
| Cozzone, PJ | 3 |
| Chong, WK | 1 |
| Paley, M | 2 |
| Wilkinson, ID | 1 |
| Hall-Craggs, MA | 2 |
| Sweeney, B | 2 |
| Harrison, MJ | 2 |
| Miller, RF | 1 |
| Kendall, BE | 2 |
| Tracey, I | 1 |
| Carr, CA | 1 |
| Guimaraes, AR | 1 |
| Worth, JL | 1 |
| Lu, D | 2 |
| Pavlakis, SG | 2 |
| Frank, Y | 2 |
| Bakshi, S | 1 |
| Pahwa, S | 1 |
| Gould, RJ | 1 |
| Sison, C | 1 |
| Hsu, C | 1 |
| Lesser, M | 1 |
| Hoberman, M | 1 |
| Barnett, T | 2 |
| Hyman, RA | 2 |
| Weiner, MW | 1 |
| Fein, G | 1 |
| Salvan, AM | 2 |
| Lamoureux, S | 1 |
| López-Villegas, D | 1 |
| Frank, I | 1 |
| Wiznia, A | 1 |
| Eidelberg, D | 1 |
| Federico, F | 1 |
| Tortorella, C | 1 |
| Andreula, CF | 1 |
| Zimatore, GB | 1 |
| Giannini, P | 1 |
| Angarano, G | 1 |
| Lucivero, V | 1 |
| Picciola, P | 1 |
| Carrara, D | 1 |
| Bellacosa, A | 1 |
| Livrea, P | 1 |
| Laubenberger, J | 1 |
| Bayer, S | 1 |
| Thiel, T | 1 |
| Hennig, J | 1 |
| Langer, M | 1 |
| Newman, SP | 1 |
| Fowler, CJ | 1 |
| Miller, R | 1 |
| Wilkinson, I | 1 |
| Lunn, S | 1 |
| Carter, S | 1 |
| Williams, I | 1 |
| von Giesen, HJ | 1 |
| Wittsack, HJ | 1 |
| Wenserski, F | 1 |
| Köller, H | 1 |
| Hefter, H | 1 |
| Arendt, G | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A Randomised, Open-label, 96-week Study Comparing the Safety and Efficacy of Three Different Combination Antiretroviral Regimens as Initial Therapy for HIV Infection.[NCT00335322] | Phase 4 | 329 participants (Actual) | Interventional | 2007-02-28 | Completed | ||
| A Cognitive Rehabilitation Program to Promote Treatment Adherence for Individuals Who Are HIV Positive With Mild Neurocognitive Difficulties[NCT02392884] | 60 participants (Anticipated) | Interventional | 2014-09-30 | Recruiting | |||
| Adaptive Working Memory and Physical Exercise Training to Improve Brain and Mitochondrial Function in MCI[NCT05948930] | 90 participants (Anticipated) | Interventional | 2024-01-31 | Not yet recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
(NCT00335322)
Timeframe: 144 weeks
| Intervention | log copies/mL (Mean) |
|---|---|
| TDF/FTC+EFV | -2.77 |
| TDF/FTC+ r/ATV | -2.88 |
| TDF/FTC + AZT+ABC | -2.54 |
(NCT00335322)
Timeframe: 48 weeks
| Intervention | log copies/mL (Mean) |
|---|---|
| TDF/FTC+EFV | -2.59 |
| TDF/FTC+r/ATV | -2.69 |
| TDF/FTC+AZT+ABC | -2.39 |
5 trials available for creatine and AIDS Dementia Complex
| Article | Year |
|---|---|
Does choice of combination antiretroviral therapy (cART) alter changes in cerebral function testing after 48 weeks in treatment-naive, HIV-1-infected individuals commencing cART? A randomized, controlled study.
Topics: AIDS Dementia Complex; Anti-HIV Agents; Antiretroviral Therapy, Highly Active; Aspartic Acid; Brain | 2010 |
A multi-center 1H MRS study of the AIDS dementia complex: validation and preliminary analysis.
Topics: AIDS Dementia Complex; Analysis of Variance; Aspartic Acid; Brain; Choline; Creatine; Excitatory Ami | 2003 |
Antiretroviral treatment alters relationship between MCP-1 and neurometabolites in HIV patients.
Topics: Adult; AIDS Dementia Complex; Anti-HIV Agents; Antiretroviral Therapy, Highly Active; Brain; Brain C | 2004 |
A multicenter in vivo proton-MRS study of HIV-associated dementia and its relationship to age.
Topics: Adult; Age Factors; AIDS Dementia Complex; Anti-HIV Agents; Aspartic Acid; Basal Ganglia; Brain; Bra | 2004 |
Proton MRS and neuropsychological correlates in AIDS dementia complex: evidence of subcortical specificity.
Topics: AIDS Dementia Complex; Antiparkinson Agents; Aspartic Acid; Basal Ganglia; Creatine; Female; Humans; | 2007 |
32 other studies available for creatine and AIDS Dementia Complex
| Article | Year |
|---|---|
White matter damage, neuroinflammation, and neuronal integrity in HAND.
Topics: Adult; AIDS Dementia Complex; Anti-HIV Agents; Antiretroviral Therapy, Highly Active; Aspartic Acid; | 2019 |
Predictors of CNS injury as measured by proton magnetic resonance spectroscopy in the setting of chronic HIV infection and CART.
Topics: Adult; AIDS Dementia Complex; Anti-Retroviral Agents; Aspartic Acid; Basal Ganglia; Choline; Chronic | 2014 |
Neurometabolite Alterations Associated With Cognitive Performance in Perinatally HIV-Infected Children.
Topics: Adolescent; AIDS Dementia Complex; Aspartic Acid; Brain; CD4 Lymphocyte Count; Child; Choline; Cogni | 2016 |
Pilot Assessment of Brain Metabolism in Perinatally HIV-Infected Youths Using Accelerated 5D Echo Planar J-Resolved Spectroscopic Imaging.
Topics: Adolescent; AIDS Dementia Complex; Algorithms; Anti-HIV Agents; Aspartic Acid; Brain; Case-Control S | 2016 |
HIV-associated neurodegeneration and neuroimmunity: multivoxel MR spectroscopy study in drug-naïve and treated patients.
Topics: Adult; AIDS Dementia Complex; Aspartic Acid; Biomarkers; Brain; Case-Control Studies; Choline; Creat | 2017 |
Factor analysis of proton MR spectroscopic imaging data in HIV infection: metabolite-derived factors help identify infection and dementia.
Topics: Adult; AIDS Dementia Complex; Analysis of Variance; Aspartic Acid; Case-Control Studies; Chi-Square | 2010 |
Accuracy and cut-off point selection in three-class classification problems using a generalization of the Youden index.
Topics: AIDS Dementia Complex; Aspartic Acid; Bias; Biomarkers; Biostatistics; Classification; Computer Simu | 2010 |
Two patterns of cerebral metabolite abnormalities are detected on proton magnetic resonance spectroscopy in HIV-infected subjects commencing antiretroviral therapy.
Topics: Adult; AIDS Dementia Complex; Anti-HIV Agents; Antiretroviral Therapy, Highly Active; Aspartic Acid; | 2012 |
Relationships among brain metabolites, cognitive function, and viral loads in antiretroviral-naïve HIV patients.
Topics: Adult; AIDS Dementia Complex; Aspartic Acid; Basal Ganglia; Brain; CD4 Lymphocyte Count; Cerebral Co | 2002 |
Identification of HIV-associated progressive multifocal leukoencephalopathy: magnetic resonance imaging and spectroscopy.
Topics: AIDS Dementia Complex; AIDS-Related Opportunistic Infections; Aspartic Acid; Astrocytes; Brain; Chol | 2003 |
Increased glial metabolites predict increased working memory network activation in HIV brain injury.
Topics: Adult; AIDS Dementia Complex; Attention; Basal Ganglia; Brain Mapping; Choline; Creatine; Frontal Lo | 2003 |
A prospective longitudinal in vivo 1H MR spectroscopy study of the SIV/macaque model of neuroAIDS.
Topics: Acute Disease; AIDS Dementia Complex; Animals; Aspartic Acid; Brain; Choline; Chronic Disease; Creat | 2004 |
In vivo 1H MRS of brain injury and repair during acute SIV infection in the macaque model of neuroAIDS.
Topics: Acute Disease; AIDS Dementia Complex; Animals; Aspartic Acid; Brain; Choline; Creatine; Female; Fron | 2004 |
Coregistration of quantitative proton magnetic resonance spectroscopic imaging with neuropathological and neurophysiological analyses defines the extent of neuronal impairments in murine human immunodeficiency virus type-1 encephalitis.
Topics: AIDS Dementia Complex; Animals; Aspartic Acid; Brain Mapping; Calcium-Binding Proteins; Capsid Prote | 2005 |
Antiretroviral therapy and its influence on the stage of brain damage in patients with HIV - 1H MRS evaluation.
Topics: Adult; AIDS Dementia Complex; Antiretroviral Therapy, Highly Active; Aspartic Acid; Brain; Choline; | 2004 |
Detection of human immunodeficiency virus induced inflammation and oxidative stress in lenticular nuclei with magnetic resonance spectroscopy despite antiretroviral therapy.
Topics: Adult; AIDS Dementia Complex; Antiretroviral Therapy, Highly Active; Aspartic Acid; Atrophy; Biomark | 2007 |
Metabolic markers of neuronal injury correlate with SIV CNS disease severity and inoculum in the macaque model of neuroAIDS.
Topics: AIDS Dementia Complex; Analysis of Variance; Animals; Aspartic Acid; Choline; Creatine; Disease Mode | 2008 |
Brain lesions in patients with AIDS: H-1 MR spectroscopy.
Topics: Abscess; Adult; AIDS Dementia Complex; Aspartic Acid; Brain Diseases; Brain Neoplasms; Choline; Crea | 1995 |
Prospective utility of cerebral proton magnetic resonance spectroscopy in monitoring HIV infection and its associated neurological impairment.
Topics: Adult; AIDS Dementia Complex; Aspartic Acid; Biomarkers; Child; Choline; Creatine; Humans; Magnetic | 1994 |
Localized brain proton MRS metabolic patterns in HIV-related encephalopathies.
Topics: AIDS Dementia Complex; Aspartic Acid; Brain; Choline; Creatine; HIV Infections; Humans; Magnetic Res | 1994 |
Localized cerebral proton MR spectroscopy in HIV infection and AIDS.
Topics: Acquired Immunodeficiency Syndrome; Adult; AIDS Dementia Complex; AIDS-Related Complex; Aspartic Aci | 1994 |
Brain choline-containing compounds are elevated in HIV-positive patients before the onset of AIDS dementia complex: A proton magnetic resonance spectroscopic study.
Topics: Adult; AIDS Dementia Complex; Aspartic Acid; Brain; Choline; Creatine; Female; HIV Seropositivity; H | 1996 |
Proton MR spectroscopy of the basal ganglia in healthy children and children with AIDS.
Topics: AIDS Dementia Complex; Aspartic Acid; Basal Ganglia; Brain Chemistry; Case-Control Studies; CD4 Lymp | 1996 |
Deep gray matter structures in HIV infection: a proton MR spectroscopic study.
Topics: Adult; AIDS Dementia Complex; Aspartic Acid; Basal Ganglia; Brain; Cerebral Ventricles; Choline; Cor | 1996 |
Cerebral metabolic alterations in human immunodeficiency virus-related encephalopathy detected by proton magnetic resonance spectroscopy. Comparison between sequences using short and long echo times.
Topics: Adult; Aged; AIDS Dementia Complex; Aspartic Acid; Brain; CD4 Lymphocyte Count; Choline; Creatine; F | 1997 |
Biochemical changes in the frontal lobe of HIV-infected individuals detected by magnetic resonance spectroscopy.
Topics: Adult; AIDS Dementia Complex; Brain Chemistry; Creatine; Female; Frontal Lobe; HIV Infections; HIV-1 | 1997 |
Brain lactate and N-acetylaspartate in pediatric AIDS encephalopathy.
Topics: AIDS Dementia Complex; Anti-HIV Agents; Aspartic Acid; Brain; Child; Child, Preschool; Creatine; Did | 1998 |
Localised 1H-MR spectroscopy for metabolic characterisation of diffuse and focal brain lesions in patients infected with HIV.
Topics: Adolescent; Adult; AIDS Dementia Complex; Aspartic Acid; Case-Control Studies; Choline; Creatine; Di | 1998 |
[Clinical uses of proton magnetic resonance spectroscopy of the brain].
Topics: AIDS Dementia Complex; Alzheimer Disease; Animals; Aspartic Acid; Brain; Brain Diseases; Brain Disea | 1998 |
Evidence of CNS impairment in HIV infection: clinical, neuropsychological, EEG, and MRI/MRS study.
Topics: Acquired Immunodeficiency Syndrome; Adult; AIDS Dementia Complex; Aspartic Acid; Atrophy; Brain; CD4 | 1998 |
[Brain proton magnetic resonance spectroscopy. Indications for diagnosis and follow-up of HIV-related encephalopathy in the adult].
Topics: AIDS Dementia Complex; Aspartic Acid; Brain; Choline; Creatine; Energy Metabolism; Humans; Magnetic | 1998 |
Basal ganglia metabolite abnormalities in minor motor disorders associated with human immunodeficiency virus type 1.
Topics: Adult; AIDS Dementia Complex; Aspartic Acid; Basal Ganglia; Choline; Creatine; Electrophysiology; HI | 2001 |