cra1000 and Chronic-Disease

Cutaneous diseases such as psoriasis and atopic dermatitis are worsened by psychic stress. We attempted to clarify the involvement of the corticotropin-releasing factor (CRF) receptor (CRFR) in stress-induced exacerbation of chronic contact dermatitis in rats. Male Wistar rats, in which chronic contact dermatitis had been induced by 2,4,6-trinitro-1-chlorobenzene (TNCB), were exposed to a 1-h period of electric foot-shock following intraperitoneal administration of CRA1000, a selective CRFR type 1 (CRFR1) antagonist, or vehicle everyday for 9 days. Histological examination of the skin showed that the epidermis significantly thickened and the number of mast cells in the dermis significantly increased by repeated exposure to stress, and that these changes were blocked by CRA1000. These results suggest that CRFR1 is involved in the stress-induced exacerbation of chronic contact dermatitis.

Topics: Animals; Chronic Disease; Dermatitis, Contact; Dermis; Electroshock; Epidermis; Foot; Immunoglobulin E; Male; Mast Cells; Picryl Chloride; Pyridines; Pyrimidines; Rats; Rats, Wistar; Receptors, Corticotropin-Releasing Hormone; Stress, Physiological