cpu-23 has been researched along with Hypertension* in 2 studies
2 other study(ies) available for cpu-23 and Hypertension
Article | Year |
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Cardiac electric activity of 1-(2-[(6-methoxyl)-naphthylmethyl])-1-methyl-N-piperidinylacethyl-6,7- dimethoxyl-1,2,3,4-tetrahydroisoquinoline in SHR and WKY rats.
1-(2-[(6-Methoxyl)-naphthylmethyl)])-1-methyl-N-piperidinylacethyl -6,7- dimethoxyl-1,2,3,4-tetrahydroisoquinoline (CPU-23), a substituted tetrahydroisoquinoline, reduced the voltages of P wave and J point, prolonged PR interval, and slowed sinus rhythm of ECG in spontaneously hypertensive rats (SHR) and age-matched normotensive WKY rats. The effects of CPU-23 on cardiac electric activity were stronger in SHR than in WKY rats (P < 0.05 or P < 0.01). The results suggest that CPU-23 have a calcium antagonistic activity on rat hearts and that calcium antagonists may exert a stronger inhibition of the cardiac electric activity in hypertensive rats than in normotensive rats. Topics: Animals; Calcium Channel Blockers; Electrocardiography; Heart Rate; Hypertension; Isoquinolines; Piperidines; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Tetrahydroisoquinolines | 1993 |
Cardiovascular effects of substituted tetrahydroisoquinolines in rats.
1. A series of substituted tetrahydroisoquinolins derived from the cleavage products of tetrandrine were found to inhibit [3H]-nitrendipine binding to rat cerebral cortical membranes. Those compounds which displaced [3H]-nitrendipine binding were also able to inhibit high KCl-induced contraction of rat aorta in vitro. 2. There was a significant correlation between the ability of these tetrahydroisoquinolines to inhibit [3H]-nitrendipine binding and KCl-induced contraction (r = 0.99, P less than 0.001). 3. CPU-23 (1-(1-[(6-methoxy)-naphth-2-yl])-propyl-2-(1-piperidine)-acetyl- 6,7- dimethoxy-1,2,3,4-tetrahydroisoquinoline), one of the most potent compounds identified in this series, behaved as a simple competitive inhibitor at the [3H]-nitrendipine binding site and reduced the apparent affinity but not the maximal number of binding sites in saturation analysis. 4. In contrast to nifedipine which caused hypotension and tachycardia, CPU-23 induced both hypotension and bradycardia in a dose-dependent manner in pentobarbitone-anaesthetized Sprague-Dawley rats, spontaneously hypertensive and age-matched normotensive WKY rats. 5. It is suggested that CPU-23 may exert its cardiovascular effects via interaction with the dihydropyridine binding site on the L-type calcium channel. Topics: Alkaloids; Animals; Aorta; Benzylisoquinolines; Blood Pressure; Calcium Channels; Cerebral Cortex; Dose-Response Relationship, Drug; Female; Heart Rate; Hypertension; Isoquinolines; Male; Nitrendipine; Piperidines; Potassium Chloride; Rats; Rats, Inbred SHR; Rats, Sprague-Dawley; Rats, Wistar; Tetrahydroisoquinolines; Vasoconstriction | 1992 |