cpp-199 and Drug-Hypersensitivity

cpp-199 has been researched along with Drug-Hypersensitivity* in 1 studies

Trials

1 trial(s) available for cpp-199 and Drug-Hypersensitivity

Article	Year
Effect of zimeldine and its metabolites on [3H]thymidine incorporation in lymphocyte cultures from psychiatric patients with or without a hypersensitivity reaction during zimeldine therapy. International clinical psychopharmacology, 1994, Volume: 9, Issue:3 Lymphocyte transformation test (LTT) was applied to 28 patients who had developed a hypersensitivity syndrome (HSS) during treatment with the antidepressant drug zimeldine. Twenty-seven patients treated with zimeldine without any symptom of an HSS were matched controls. Zimeldine and its metabolites norzimeldine and CPP 200 all induced statistically significant increased [3H]thymidine incorporation in cultured lymphocytes from the HSS patients compared with the controls, norzimeldine being the most potent inducer. The results indicate an immunoreactive process in the development of the HSS induced by zimeldine. Topics: Adult; Aged; Antidepressive Agents; Dose-Response Relationship, Drug; Drug Hypersensitivity; Female; Humans; Lymphocyte Activation; Lymphocyte Culture Test, Mixed; Male; Middle Aged; Thymidine; Zimeldine	1994

Article

Year

Effect of zimeldine and its metabolites on [3H]thymidine incorporation in lymphocyte cultures from psychiatric patients with or without a hypersensitivity reaction during zimeldine therapy.

International clinical psychopharmacology, 1994, Volume: 9, Issue:3

Lymphocyte transformation test (LTT) was applied to 28 patients who had developed a hypersensitivity syndrome (HSS) during treatment with the antidepressant drug zimeldine. Twenty-seven patients treated with zimeldine without any symptom of an HSS were matched controls. Zimeldine and its metabolites norzimeldine and CPP 200 all induced statistically significant increased [3H]thymidine incorporation in cultured lymphocytes from the HSS patients compared with the controls, norzimeldine being the most potent inducer. The results indicate an immunoreactive process in the development of the HSS induced by zimeldine.

Topics: Adult; Aged; Antidepressive Agents; Dose-Response Relationship, Drug; Drug Hypersensitivity; Female; Humans; Lymphocyte Activation; Lymphocyte Culture Test, Mixed; Male; Middle Aged; Thymidine; Zimeldine

1994