cpi203 and Carcinoma--Pancreatic-Ductal

Pancreatic ductal adenocarcinoma (PDAC) is characterized by a highly desmoplastic reaction, warranting intense cancer-stroma communication. In this study, we interrogated the contribution of the BET family of chromatin adaptors to the cross-talk between PDAC cells and the tumor stroma. Short-term treatment of orthotopic xenograft tumors with CPI203, a small-molecule inhibitor of BET proteins, resulted in broad changes in the expression of genes encoding components of the extracellular matrix (matrisome) in both cancer and stromal cells. Remarkably, more than half of matrisome genes were expressed by cancer cells.

Topics: Acetamides; Animals; Azepines; Cancer-Associated Fibroblasts; Carcinoma, Pancreatic Ductal; Cell Communication; Cell Line, Tumor; Cell Proliferation; Collagen; Extracellular Matrix Proteins; Gene Expression Regulation, Neoplastic; Humans; Mice; Pancreatic Neoplasms; Tumor Microenvironment; Xenograft Model Antitumor Assays