cp-673-451 and Hypertrophy

The platelet-derived growth factor receptors alpha and beta (PDGFRα and PDGFRβ) mark fibroadipogenic progenitor cells/fibroblasts and pericytes in skeletal muscle, respectively. While the role that these cells play in muscle growth and development has been evaluated, it was not known whether the PDGF receptors activate signaling pathways that control transcriptional and functional changes during skeletal muscle hypertrophy. To evaluate this, we inhibited PDGFR signaling in mice subjected to a synergist ablation muscle growth procedure, and performed analyses 3 and 10 days after induction of hypertrophy. The results from this study indicate that PDGF signaling is required for fiber hypertrophy, extracellular matrix production, and angiogenesis that occur during muscle growth.

Topics: Achilles Tendon; Animals; Animals, Newborn; Benzimidazoles; Extracellular Matrix; Gene Expression Profiling; Gene Expression Regulation; Hypertrophy; Mice; Mice, Inbred C57BL; Mice, Transgenic; Muscle Fibers, Skeletal; Muscle, Skeletal; Neovascularization, Physiologic; Platelet-Derived Growth Factor; Quinolines; Receptor, Platelet-Derived Growth Factor alpha; Receptor, Platelet-Derived Growth Factor beta; Signal Transduction; Weight-Bearing