coumestrol has been researched along with Alzheimer-Disease* in 2 studies
2 other study(ies) available for coumestrol and Alzheimer-Disease
| Article | Year |
|---|---|
Phytoestrogen Coumestrol Selectively Inhibits Monoamine Oxidase-A and Amyloid β Self-Aggregation.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Coumestrol; Flavin-Adenine Dinucleotide; Flavonoids; Humans; Molecular Docking Simulation; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Phytoestrogens; Structure-Activity Relationship | 2022 |
Phenolic compounds from Pueraria lobata protect PC12 cells against Aβ-induced toxicity.
Bioassay-guided fractionation of the EtOAc-soluble extract of Pueraria lobata based on the inhibition of Aβ-induced toxicity in PC12 cells resulted in the isolation of four known active compounds, genistein (8), biochanin A (9), sissotrin (10), and puerol B (11). Of these, genistein (8) and biochanin A (9) exhibited potent neuroprotective effects with ED(50) values of 33.7 and 27.8 μM, respectively. In addition, a new coumestan, 2-(α,α-dimethylallyl)coumestrol (1) was isolated and characterized, but proved to be inactive, as were additional seven known compounds. The structure of new compound 1 was determined using spectroscopic techniques. Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Cell Survival; Coumestrol; Drug Discovery; Flavonoids; Genistein; Inhibitory Concentration 50; Magnetic Resonance Spectroscopy; Medicine, East Asian Traditional; Molecular Structure; Neurons; Neuroprotective Agents; PC12 Cells; Phenols; Plant Extracts; Plant Roots; Polyphenols; Pueraria; Rats; Spectrometry, Mass, Electrospray Ionization | 2010 |