coumarin has been researched along with Venous Insufficiency in 7 studies
2H-chromen-2-one: coumarin derivative
Venous Insufficiency: Impaired venous blood flow or venous return (venous stasis), usually caused by inadequate venous valves. Venous insufficiency often occurs in the legs, and is associated with EDEMA and sometimes with VENOUS STASIS ULCERS at the ankle.
| Excerpt | Relevance | Reference |
|---|---|---|
| "No evidence was obtained that the studied polymorphism in CYP2A6 is a determinant of the coumarin-associated liver dysfunction." | 9.10 | Single copy of variant CYP2A6 alleles does not confer susceptibility to liver dysfunction in patients treated with coumarin. ( Burian, M; Freudenstein, J; Henneicke-von Zepelin, HH; Legrum, W; Naser-Hijazi, B; Tegtmeier, M, 2003) |
| "No evidence was obtained that the studied polymorphism in CYP2A6 is a determinant of the coumarin-associated liver dysfunction." | 5.10 | Single copy of variant CYP2A6 alleles does not confer susceptibility to liver dysfunction in patients treated with coumarin. ( Burian, M; Freudenstein, J; Henneicke-von Zepelin, HH; Legrum, W; Naser-Hijazi, B; Tegtmeier, M, 2003) |
| "Coumarin is a secondary phytochemical with hepatotoxic and carcinogenic properties." | 2.46 | Toxicology and risk assessment of coumarin: focus on human data. ( Abraham, K; Heinemeyer, G; Lampen, A; Lindtner, O; Wöhrlin, F, 2010) |
| "Coumarin is a drug which is extensively used to treat lymphedema." | 2.40 | [Acute cytolytic hepatitis caused by coumarin. 2 cases]. ( Becker, MC; Beurton, I; Bresson-Hadni, S; Carbillet, JP; Hrusovsky, S; Koch, S; Miguet, JP; Monnot, B; Vanlemmens, C, 1997) |
| "Non-fatal pulmonary embolism after onset of treatment occurred in both cohorts with an equal frequency of 13%." | 1.28 | Surgical thrombectomy versus conservative treatment for deep venous thrombosis; functional comparison of long-term results. ( Gänger, KH; Nachbur, BH; Ris, HB; Zurbrügg, H, 1989) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (14.29) | 18.7374 |
| 1990's | 2 (28.57) | 18.2507 |
| 2000's | 2 (28.57) | 29.6817 |
| 2010's | 2 (28.57) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Belczak, SQ | 1 |
| Sincos, IR | 1 |
| Campos, W | 1 |
| Beserra, J | 1 |
| Nering, G | 1 |
| Aun, R | 1 |
| Abraham, K | 1 |
| Wöhrlin, F | 1 |
| Lindtner, O | 1 |
| Heinemeyer, G | 1 |
| Lampen, A | 1 |
| Burian, M | 1 |
| Freudenstein, J | 1 |
| Tegtmeier, M | 1 |
| Naser-Hijazi, B | 1 |
| Henneicke-von Zepelin, HH | 1 |
| Legrum, W | 1 |
| Koch, S | 1 |
| Beurton, I | 1 |
| Bresson-Hadni, S | 1 |
| Monnot, B | 1 |
| Hrusovsky, S | 1 |
| Becker, MC | 1 |
| Vanlemmens, C | 1 |
| Carbillet, JP | 1 |
| Miguet, JP | 1 |
| Jörger, U | 1 |
| Ludwig, MM | 1 |
| Vahlensieck, M | 1 |
| Stumpe, KO | 1 |
| Clement, DL | 1 |
| Gänger, KH | 1 |
| Nachbur, BH | 1 |
| Ris, HB | 1 |
| Zurbrügg, H | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Randomized, Double-blind, Placebo-controlled Clinical Trial to Assess the Efficacy of µSmin® Plus (Dietary Supplement) in Chronic Venous Insufficiency Symptoms Relief[NCT04101201] | 73 participants (Actual) | Interventional | 2019-11-15 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
3 reviews available for coumarin and Venous Insufficiency
| Article | Year |
|---|---|
Toxicology and risk assessment of coumarin: focus on human data.
Topics: Animals; Biotransformation; Chemical and Drug Induced Liver Injury; Coumarins; Edema; Flavoring Agen | 2010 |
[Acute cytolytic hepatitis caused by coumarin. 2 cases].
Topics: Acute Disease; Adult; Anticoagulants; Chemical and Drug Induced Liver Injury; Coumarins; Female; Hum | 1997 |
Management of venous edema: insights from an international task force.
Topics: Anticoagulants; Bandages; Calcium Dobesilate; Cardiovascular Agents; Chronic Disease; Controlled Cli | 2000 |
2 trials available for coumarin and Venous Insufficiency
| Article | Year |
|---|---|
Veno-active drugs for chronic venous disease: A randomized, double-blind, placebo-controlled parallel-design trial.
Topics: Biomechanical Phenomena; Brazil; Cardiovascular Agents; Chronic Disease; Coumarins; Diosmin; Double- | 2014 |
Single copy of variant CYP2A6 alleles does not confer susceptibility to liver dysfunction in patients treated with coumarin.
Topics: Adult; Aged; Anticoagulants; Aryl Hydrocarbon Hydroxylases; Chemical and Drug Induced Liver Injury; | 2003 |
2 other studies available for coumarin and Venous Insufficiency
| Article | Year |
|---|---|
Intermittent edema of the upper and lower extremities and the abdominal wall caused by membranous stenosis of the superior vena cava and membranous obstruction of the inferior vena cava.
Topics: Abdominal Muscles; Adult; Anticoagulants; Arm; Bandages; Clothing; Coumarins; Edema; Humans; Leg; Ma | 1996 |
Surgical thrombectomy versus conservative treatment for deep venous thrombosis; functional comparison of long-term results.
Topics: Bandages; Combined Modality Therapy; Coumarins; Drug Therapy, Combination; Follow-Up Studies; Hepari | 1989 |