coumarin has been researched along with Melanoma in 7 studies
2H-chromen-2-one: coumarin derivative
Melanoma: A malignant neoplasm derived from cells that are capable of forming melanin, which may occur in the skin of any part of the body, in the eye, or, rarely, in the mucous membranes of the genitalia, anus, oral cavity, or other sites. It occurs mostly in adults and may originate de novo or from a pigmented nevus or malignant lentigo. Melanomas frequently metastasize widely, and the regional lymph nodes, liver, lungs, and brain are likely to be involved. The incidence of malignant skin melanomas is rising rapidly in all parts of the world. (Stedman, 25th ed; from Rook et al., Textbook of Dermatology, 4th ed, p2445)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Both coumarin (1,2-benzopyrone) and warfarin (4-hydroxycoumarin) have been shown to prevent the recurrence of malignant melanoma." | 9.07 | Treatment with coumarin to prevent or delay recurrence of malignant melanoma. ( Breslin, B; Browne, H; Browne, HY; Corrigan, T; Daly, L; Daly, P; Edwards, G; Gaffney, E; Lynch, G; Thornes, RD, 1994) |
| "Coumarin (1,2-benzopyrone) as a daily oral dose of 50 mg was evaluated in a multicentre prospectively randomized, double-blind, placebo-controlled trial to prevent early recurrence of malignant melanoma TNM Stage IB (Breslow thickness greater than 1." | 9.06 | Prevention of early recurrence of high risk malignant melanoma by coumarin. Irish Melanoma Group. ( Browne, H; Corrigan, T; Daly, L; Daly, P; Edwards, G; Keane, F; Lynch, G; O'Loughlin, S; Tanner, A; Thornes, D, 1989) |
| "A375 melanoma cancer cells were used for testing cellular entry and anticancer potentials of HMC and nano-7-hydroxy-6-methoxy coumarin (NHMC) through several standard protocols." | 7.76 | Polymeric nanoparticle encapsulation of a naturally occurring plant scopoletin and its effects on human melanoma cell A375. ( Bhattacharyya, SS; Boujedaini, N; Khuda-Bukhsh, AR; Paul, S, 2010) |
| "Based on previous results demonstrating that coumarin and cimetidine render objective tumor regressions in renal cell carcinoma, we conducted a pilot study to determine whether these drugs possess activity against malignant melanoma." | 7.67 | Treatment of advanced malignant melanoma with coumarin and cimetidine: a pilot study. ( Butler, K; Cantrell, J; Marshall, ME; Mendelsohn, L; Wiseman, C, 1989) |
| "Immunostimulant therapy with coumarin and cimetidine was evaluated in 17 patients with advanced malignant melanoma." | 7.67 | Combined treatment of advanced malignant melanoma with coumarin and cimetidine. A phase II study. ( Langvad, E; Pedersen, L; Rose, C, 1987) |
| "Unlike other skin cancers, CM does not clearly correlate with exposure to ultraviolet radiation." | 5.35 | The increase in melanoma: are dietary furocoumarins responsible? ( Dowdy, JC; Sayre, RM, 2008) |
| "Both coumarin (1,2-benzopyrone) and warfarin (4-hydroxycoumarin) have been shown to prevent the recurrence of malignant melanoma." | 5.07 | Treatment with coumarin to prevent or delay recurrence of malignant melanoma. ( Breslin, B; Browne, H; Browne, HY; Corrigan, T; Daly, L; Daly, P; Edwards, G; Gaffney, E; Lynch, G; Thornes, RD, 1994) |
| "Coumarin (1,2-benzopyrone) as a daily oral dose of 50 mg was evaluated in a multicentre prospectively randomized, double-blind, placebo-controlled trial to prevent early recurrence of malignant melanoma TNM Stage IB (Breslow thickness greater than 1." | 5.06 | Prevention of early recurrence of high risk malignant melanoma by coumarin. Irish Melanoma Group. ( Browne, H; Corrigan, T; Daly, L; Daly, P; Edwards, G; Keane, F; Lynch, G; O'Loughlin, S; Tanner, A; Thornes, D, 1989) |
| "A375 melanoma cancer cells were used for testing cellular entry and anticancer potentials of HMC and nano-7-hydroxy-6-methoxy coumarin (NHMC) through several standard protocols." | 3.76 | Polymeric nanoparticle encapsulation of a naturally occurring plant scopoletin and its effects on human melanoma cell A375. ( Bhattacharyya, SS; Boujedaini, N; Khuda-Bukhsh, AR; Paul, S, 2010) |
| "Based on previous results demonstrating that coumarin and cimetidine render objective tumor regressions in renal cell carcinoma, we conducted a pilot study to determine whether these drugs possess activity against malignant melanoma." | 3.67 | Treatment of advanced malignant melanoma with coumarin and cimetidine: a pilot study. ( Butler, K; Cantrell, J; Marshall, ME; Mendelsohn, L; Wiseman, C, 1989) |
| "Immunostimulant therapy with coumarin and cimetidine was evaluated in 17 patients with advanced malignant melanoma." | 3.67 | Combined treatment of advanced malignant melanoma with coumarin and cimetidine. A phase II study. ( Langvad, E; Pedersen, L; Rose, C, 1987) |
| "Unlike other skin cancers, CM does not clearly correlate with exposure to ultraviolet radiation." | 1.35 | The increase in melanoma: are dietary furocoumarins responsible? ( Dowdy, JC; Sayre, RM, 2008) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (42.86) | 18.7374 |
| 1990's | 2 (28.57) | 18.2507 |
| 2000's | 1 (14.29) | 29.6817 |
| 2010's | 1 (14.29) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Khuda-Bukhsh, AR | 1 |
| Bhattacharyya, SS | 1 |
| Paul, S | 1 |
| Boujedaini, N | 1 |
| Sayre, RM | 1 |
| Dowdy, JC | 1 |
| Thornes, RD | 1 |
| Daly, L | 2 |
| Lynch, G | 2 |
| Breslin, B | 1 |
| Browne, H | 2 |
| Browne, HY | 1 |
| Corrigan, T | 2 |
| Daly, P | 2 |
| Edwards, G | 2 |
| Gaffney, E | 1 |
| Thornes, D | 1 |
| Tanner, A | 1 |
| Keane, F | 1 |
| O'Loughlin, S | 1 |
| Marshall, ME | 1 |
| Butler, K | 1 |
| Cantrell, J | 1 |
| Wiseman, C | 1 |
| Mendelsohn, L | 1 |
| Pedersen, L | 1 |
| Rose, C | 1 |
| Langvad, E | 1 |
2 trials available for coumarin and Melanoma
| Article | Year |
|---|---|
Treatment with coumarin to prevent or delay recurrence of malignant melanoma.
Topics: Chemotherapy, Adjuvant; Coumarins; Double-Blind Method; Female; Humans; Life Tables; Male; Melanoma; | 1994 |
Prevention of early recurrence of high risk malignant melanoma by coumarin. Irish Melanoma Group.
Topics: Adult; Combined Modality Therapy; Coumarins; Female; Humans; Male; Melanoma; Middle Aged; Multicente | 1989 |
5 other studies available for coumarin and Melanoma
| Article | Year |
|---|---|
Polymeric nanoparticle encapsulation of a naturally occurring plant scopoletin and its effects on human melanoma cell A375.
Topics: Apoptosis; Caspase 3; Coumarins; Down-Regulation; Humans; Imidazoles; Lactic Acid; Melanoma; Nanopar | 2010 |
The increase in melanoma: are dietary furocoumarins responsible?
Topics: Animals; Coumarins; Diet; Family Health; Furocoumarins; Humans; Light; Melanoma; Models, Biological; | 2008 |
2nd Proceedings of The International Society of Coumarin Investigators (ISCI). 1,2-Benzopyrone (Coumarin): update on mechanisms of action - Treatment of renal cell carcinoma and prostate cancer - Prevention of melanoma recurrence. Hamburg, Germany, 9 Marc
Topics: Animals; Antineoplastic Agents; Carcinoma, Renal Cell; Coumarins; Humans; Kidney Neoplasms; Male; Me | 1994 |
Treatment of advanced malignant melanoma with coumarin and cimetidine: a pilot study.
Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Cimetidine; Coumarin | 1989 |
Combined treatment of advanced malignant melanoma with coumarin and cimetidine. A phase II study.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Cimetidine; Coumarins; Drug Evaluation; | 1987 |