Page last updated: 2024-10-17

coumarin and Edema

coumarin has been researched along with Edema in 17 studies

2H-chromen-2-one: coumarin derivative

Edema: Abnormal fluid accumulation in TISSUES or body cavities. Most cases of edema are present under the SKIN in SUBCUTANEOUS TISSUE.

Research Excerpts

ExcerptRelevanceReference
"The aim of the study was to explore the inhibition efficacy of new synthetic coumarinolignans (SCLs) against the secretion of pro-inflammatory cytokines in two in vivo models of inflammation."7.96New synthetic coumarinolignans as attenuators of pro-inflammatory cytokines in LPS-induced sepsis and carrageenan-induced paw oedema models. ( Araya, H; Begum Ahil, S; Fujimoto, Y; Hira, K; Kulkarni, OP; Kumar, SS, 2020)
"The dose-response relationship upon intraperitoneal administration of coumarin (C) and 7-hydroxycoumarin (7HC) in rats was evaluated using the carrageenan induced edema of the hind paw."7.66Investigation of the dose-response relationship upon intraperitoneal administration of coumarin and 7-hydroxycoumarin on the carrageenan induced edema of the rat hind paw. ( Hardt, TJ; Ritschel, WA, 1983)
"The aim of the study was to explore the inhibition efficacy of new synthetic coumarinolignans (SCLs) against the secretion of pro-inflammatory cytokines in two in vivo models of inflammation."3.96New synthetic coumarinolignans as attenuators of pro-inflammatory cytokines in LPS-induced sepsis and carrageenan-induced paw oedema models. ( Araya, H; Begum Ahil, S; Fujimoto, Y; Hira, K; Kulkarni, OP; Kumar, SS, 2020)
"The dose-response relationship upon intraperitoneal administration of coumarin (C) and 7-hydroxycoumarin (7HC) in rats was evaluated using the carrageenan induced edema of the hind paw."3.66Investigation of the dose-response relationship upon intraperitoneal administration of coumarin and 7-hydroxycoumarin on the carrageenan induced edema of the rat hind paw. ( Hardt, TJ; Ritschel, WA, 1983)
" No adverse events were recorded."2.90Effectiveness and safety of a mixture of diosmin, coumarin and arbutin (Linfadren ( Cacchio, A; De Blasis, E; Di Carlo, G; Vincenza, C, 2019)
"Coumarin is a secondary phytochemical with hepatotoxic and carcinogenic properties."2.46Toxicology and risk assessment of coumarin: focus on human data. ( Abraham, K; Heinemeyer, G; Lampen, A; Lindtner, O; Wöhrlin, F, 2010)

Research

Studies (17)

TimeframeStudies, this research(%)All Research%
pre-19905 (29.41)18.7374
1990's1 (5.88)18.2507
2000's5 (29.41)29.6817
2010's4 (23.53)24.3611
2020's2 (11.76)2.80

Authors

AuthorsStudies
Kontogiorgis, CA2
Hadjipavlou-Litina, DJ4
Symeonidis, T1
Chamilos, M1
Kallitsakis, M1
Litinas, KE1
Kumar, SS1
Hira, K1
Begum Ahil, S1
Kulkarni, OP1
Araya, H1
Fujimoto, Y1
Alshibl, HM1
Al-Abdullah, ES1
Haiba, ME1
Alkahtani, HM1
Awad, GEA1
Mahmoud, AH1
Ibrahim, BMM1
Bari, A1
Villinger, A1
Cacchio, A1
Di Carlo, G1
Vincenza, C1
De Blasis, E1
Belczak, SQ1
Sincos, IR1
Campos, W1
Beserra, J1
Nering, G1
Aun, R1
Melagraki, G1
Afantitis, A1
Igglessi-Markopoulou, O1
Detsi, A1
Koufaki, M1
Kontogiorgis, C1
Abraham, K1
Wöhrlin, F1
Lindtner, O1
Heinemeyer, G1
Lampen, A1
Sashidhara, KV1
Kumar, M1
Modukuri, RK1
Sonkar, R1
Bhatia, G1
Khanna, AK1
Rai, S1
Shukla, R1
SZIRMAI, E2
Hardt, TJ1
Ritschel, WA1
Miller, SH1
Abell, M1
Buck, D1
Kress, D1
Davis, TS1
DeMuth, RJ1
Gaffney, RM1
Jörger, U1
Ludwig, MM1
Vahlensieck, M1
Stumpe, KO1
Clement, DL1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Randomized, Double-blind, Placebo-controlled Clinical Trial to Assess the Efficacy of µSmin® Plus (Dietary Supplement) in Chronic Venous Insufficiency Symptoms Relief[NCT04101201]73 participants (Actual)Interventional2019-11-15Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

2 reviews available for coumarin and Edema

ArticleYear
Toxicology and risk assessment of coumarin: focus on human data.
    Molecular nutrition & food research, 2010, Volume: 54, Issue:2

    Topics: Animals; Biotransformation; Chemical and Drug Induced Liver Injury; Coumarins; Edema; Flavoring Agen

2010
Management of venous edema: insights from an international task force.
    Angiology, 2000, Volume: 51, Issue:1

    Topics: Anticoagulants; Bandages; Calcium Dobesilate; Cardiovascular Agents; Chronic Disease; Controlled Cli

2000

Trials

2 trials available for coumarin and Edema

ArticleYear
Effectiveness and safety of a mixture of diosmin, coumarin and arbutin (Linfadren
    Clinical rehabilitation, 2019, Volume: 33, Issue:5

    Topics: Adult; Aged; Arbutin; Child; Combined Modality Therapy; Coumarins; Diosmin; Drug Combinations; Edema

2019
Veno-active drugs for chronic venous disease: A randomized, double-blind, placebo-controlled parallel-design trial.
    Phlebology, 2014, Volume: 29, Issue:7

    Topics: Biomechanical Phenomena; Brazil; Cardiovascular Agents; Chronic Disease; Coumarins; Diosmin; Double-

2014

Other Studies

13 other studies available for coumarin and Edema

ArticleYear
Synthesis and biological evaluation of novel coumarin derivatives with a 7-azomethine linkage.
    Bioorganic & medicinal chemistry letters, 2004, Feb-09, Volume: 14, Issue:3

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Antioxidants; Azo Compounds; Carrageenan; Coumarin

2004
Synthesis and antiinflammatory activity of coumarin derivatives.
    Journal of medicinal chemistry, 2005, Oct-06, Volume: 48, Issue:20

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Experimental; Carrageenan; Coumarins; C

2005
Synthesis of hydroxycoumarins and hydroxybenzo[f]- or [h]coumarins as lipid peroxidation inhibitors.
    Bioorganic & medicinal chemistry letters, 2009, Feb-15, Volume: 19, Issue:4

    Topics: Animals; Antioxidants; Biphenyl Compounds; Combinatorial Chemistry Techniques; Coumarins; Edema; Lip

2009
New synthetic coumarinolignans as attenuators of pro-inflammatory cytokines in LPS-induced sepsis and carrageenan-induced paw oedema models.
    Inflammopharmacology, 2020, Volume: 28, Issue:5

    Topics: Animals; Anti-Inflammatory Agents; Carrageenan; Coumarins; Cytokines; Disease Models, Animal; Edema;

2020
Synthesis and Evaluation of New Coumarin Derivatives as Antioxidant, Antimicrobial, and Anti-Inflammatory Agents.
    Molecules (Basel, Switzerland), 2020, Jul-16, Volume: 25, Issue:14

    Topics: Animals; Anti-Infective Agents; Anti-Inflammatory Agents; Antioxidants; Coumarins; Edema; Formaldehy

2020
Synthesis and evaluation of the antioxidant and anti-inflammatory activity of novel coumarin-3-aminoamides and their alpha-lipoic acid adducts.
    European journal of medicinal chemistry, 2009, Volume: 44, Issue:7

    Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Coumarins; Edema; Female; Glycine max; Lipoxygenase

2009
Synthesis and anti-inflammatory activity of novel biscoumarin-chalcone hybrids.
    Bioorganic & medicinal chemistry letters, 2011, Aug-01, Volume: 21, Issue:15

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Chalcone; Coumarins; Edema; Microsomes; Rats

2011
[Therapeutic and diuretic effects of dicumarin in hydrops gravidarum].
    Magyar noorvosok lapja, 1951, Volume: 14, Issue:12

    Topics: Coumarins; Diuretics; Edema; Female; Humans; Pregnancy

1951
[The therapeutic and diuretic effect of dicoumarin in pregnancy dropsy].
    Gynaecologia. International monthly review of obstetrics and gynecology. Revue internationale mensuelle d'obstetrique et de gynecologie. Monatsschrift fur Geburtshilfe und Gynakologie, 1952, Volume: 133, Issue:4

    Topics: Coumarins; Dicumarol; Diuretics; Edema; Female; Pregnancy; Pregnancy Complications

1952
Investigation of the dose-response relationship upon intraperitoneal administration of coumarin and 7-hydroxycoumarin on the carrageenan induced edema of the rat hind paw.
    Arzneimittel-Forschung, 1983, Volume: 33, Issue:12

    Topics: Animals; Anti-Inflammatory Agents; Carrageenan; Coumarins; Dose-Response Relationship, Drug; Edema;

1983
Effects of 5,6 benzo-alphapyrone on traumatic edema due to crush and burn injury.
    The Journal of trauma, 1981, Volume: 21, Issue:5

    Topics: Animals; Burns; Coumarins; Edema; Hindlimb; Male; Organ Size; Rats

1981
Resolution rates of artificially produced protein and amino acid oedemas and the effects of a benzopyrone.
    British journal of experimental pathology, 1981, Volume: 62, Issue:5

    Topics: Amino Acids; Animals; Blood Proteins; Coumarins; Edema; Male; Povidone; Rats; Rats, Inbred Strains;

1981
Intermittent edema of the upper and lower extremities and the abdominal wall caused by membranous stenosis of the superior vena cava and membranous obstruction of the inferior vena cava.
    European journal of medical research, 1996, Apr-18, Volume: 1, Issue:7

    Topics: Abdominal Muscles; Adult; Anticoagulants; Arm; Bandages; Clothing; Coumarins; Edema; Humans; Leg; Ma

1996