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coumarin and Congenital Familial Lymphedema

coumarin has been researched along with Congenital Familial Lymphedema in 26 studies

2H-chromen-2-one: coumarin derivative

Research Excerpts

ExcerptRelevanceReference
"Coumarin is not effective therapy for women who have lymphedema of the arm after treatment for breast cancer."9.09Lack of effect of coumarin in women with lymphedema after treatment for breast cancer. ( Kugler, JW; Levitt, R; Loprinzi, CL; Michalak, JC; Mowat, RB; Novotny, P; Quella, SK; Rooke, TW; Sloan, JA; Stella, PJ; Tschetter, LK; Windschitl, H, 1999)
"In a randomized, double-blind, parallel group study, we compared the clinical efficacy of coumarin 90 mg/day (Group A) with 135 mg/day (Group B) in 77 women (age 35-65 years) with lymphedema of the upper limb secondary to surgery and irradiation for treatment of breast cancer."9.09Comparative study of the clinical efficacy of two different coumarin dosages in the management of arm lymphedema after treatment for breast cancer. ( Alcaide, A; Alcoba, C; Azcona, JM; Burgos, A; Garrido, J; Lorente, C; Moreno, E; Murillo, E; Olsina-Kissler, J; Olsina-Pavia, J; Samaniego, E; Serra, M, 1999)
"Although there remains some significant controversy regarding the use and benefits of coumarin (5,6-benzo-alpha pyrone), it would seem that targeted appropriate and monitored use of the drug does have a significant role in the treatment of lymphedemas."8.82Pharmacogenomics: its role in re-establishing coumarin as treatment for lymphedema. ( Farinola, N; Piller, N, 2005)
"Coumarin is an effective pharmacological treatment, but is banned in some countries due to incidences of hepatotoxicity in rats and mice, and the rare finding of similar hepatotoxicity in humans."6.44CYP2A6 polymorphisms: is there a role for pharmacogenomics in preventing coumarin-induced hepatotoxicity in lymphedema patients? ( Farinola, N; Piller, NB, 2007)
"Coumarin is not effective therapy for women who have lymphedema of the arm after treatment for breast cancer."5.09Lack of effect of coumarin in women with lymphedema after treatment for breast cancer. ( Kugler, JW; Levitt, R; Loprinzi, CL; Michalak, JC; Mowat, RB; Novotny, P; Quella, SK; Rooke, TW; Sloan, JA; Stella, PJ; Tschetter, LK; Windschitl, H, 1999)
"In a randomized, double-blind, parallel group study, we compared the clinical efficacy of coumarin 90 mg/day (Group A) with 135 mg/day (Group B) in 77 women (age 35-65 years) with lymphedema of the upper limb secondary to surgery and irradiation for treatment of breast cancer."5.09Comparative study of the clinical efficacy of two different coumarin dosages in the management of arm lymphedema after treatment for breast cancer. ( Alcaide, A; Alcoba, C; Azcona, JM; Burgos, A; Garrido, J; Lorente, C; Moreno, E; Murillo, E; Olsina-Kissler, J; Olsina-Pavia, J; Samaniego, E; Serra, M, 1999)
"We conducted a randomized, double-blind, placebo-controlled, crossover trial of 5,6-benzo-[alpha]-pyrone in 31 patients with postmastectomy lymphedema of the arm and 21 patients with lymphedema of the leg of various causes (this agent, also known as 56 BaP, 1,2-benzopyrone, or coumarin, is not an anticoagulant)."5.07Treatment of lymphedema of the arms and legs with 5,6-benzo-[alpha]-pyrone. ( Casley-Smith, JR; Morgan, RG; Piller, NB, 1993)
"Although there remains some significant controversy regarding the use and benefits of coumarin (5,6-benzo-alpha pyrone), it would seem that targeted appropriate and monitored use of the drug does have a significant role in the treatment of lymphedemas."4.82Pharmacogenomics: its role in re-establishing coumarin as treatment for lymphedema. ( Farinola, N; Piller, N, 2005)
"Lympidem is a coumarin derivative which is advocated for treatment of mainly chronic lymphedema by the manufacturer."3.75Lympidem (a coumarin derivative) induced reversible hepatotoxicity in an adult Sri Lankan. ( Jayawardana, MA; Satarasinghe, RL, 2009)
"A study was performed on the use of an ideal phlebolymphological association (Tonka Beans, Gingko Biloba, Melilotus Officinalis) as a practical standpoint in the treatment of lymphedema of lower limbs in order to create an efficacious dose of Coumarin, Benzopyrones and Ginkolidi."3.69[Contribution of a combination of alpha and beta benzopyrones, flavonoids and natural terpenes in the treatment of lymphedema of the lower limbs at the 2d stage of the surgical classification]. ( Cataldi, A; Cerreta, G; Derwish, A; Donini, I; Occhionorelli, S; Schettino, A; Vettorello, G, 1996)
"Diethylcarbamazine (DEC) was studied with and without 56 BaP."2.67Reduction of filaritic lymphoedema and elephantiasis by 5,6 benzo-alpha-pyrone (coumarin), and the effects of diethylcarbamazine (DEC). ( Casley-Smith, J; Casley-Smith, JR; Jamal, S, 1993)
"Coumarin is a secondary phytochemical with hepatotoxic and carcinogenic properties."2.46Toxicology and risk assessment of coumarin: focus on human data. ( Abraham, K; Heinemeyer, G; Lampen, A; Lindtner, O; Wöhrlin, F, 2010)
"Coumarin is an effective pharmacological treatment, but is banned in some countries due to incidences of hepatotoxicity in rats and mice, and the rare finding of similar hepatotoxicity in humans."2.44CYP2A6 polymorphisms: is there a role for pharmacogenomics in preventing coumarin-induced hepatotoxicity in lymphedema patients? ( Farinola, N; Piller, NB, 2007)

Research

Studies (26)

TimeframeStudies, this research(%)All Research%
pre-19903 (11.54)18.7374
1990's16 (61.54)18.2507
2000's5 (19.23)29.6817
2010's2 (7.69)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Leung, EY1
Tirlapur, SA1
Meads, C1
Satarasinghe, RL1
Jayawardana, MA1
Rockson, SG1
Abraham, K1
Wöhrlin, F1
Lindtner, O1
Heinemeyer, G1
Lampen, A1
Boursier, V1
Farinola, N2
Piller, N1
Piller, NB4
Landmann, C1
Casley-Smith, JR8
Wang, CT1
Zi-hai, C1
Jamal, S2
Casley-Smith, J1
Morgan, RG1
Chang, TS1
Gan, JL1
Fu, KD1
Huang, WY1
Vettorello, G1
Cerreta, G1
Derwish, A1
Cataldi, A1
Schettino, A1
Occhionorelli, S1
Donini, I1
Loprinzi, CL2
Sloan, J1
Kugler, J1
Kugler, JW1
Sloan, JA1
Rooke, TW1
Quella, SK1
Novotny, P1
Mowat, RB1
Michalak, JC1
Stella, PJ1
Levitt, R1
Tschetter, LK1
Windschitl, H1
Ganz, PA1
Witte, CL1
Burgos, A1
Alcaide, A1
Alcoba, C1
Azcona, JM1
Garrido, J1
Lorente, C1
Moreno, E1
Murillo, E1
Olsina-Pavia, J1
Olsina-Kissler, J1
Samaniego, E1
Serra, M1
Alder, S1
O'Rourke, ME1
Knight, KR2
Hurley, JV1
Hickey, MJ1
Lepore, DA1
O'Brien, BM2
Khazanchi, RK1
Pederson, WC1
McCann, JJ1
Coe, SA1
Clodius, L1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Phase I Study Evaluating the Safety of Bevacizumab in Women With a History of Breast Cancer Suffering From Moderate to Severe Upper Extremity Lymphedema[NCT00318513]Phase 135 participants InterventionalNot yet recruiting
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

6 reviews available for coumarin and Congenital Familial Lymphedema

ArticleYear
The management of secondary lower limb lymphoedema in cancer patients: a systematic review.
    Palliative medicine, 2015, Volume: 29, Issue:2

    Topics: Coumarins; Disease Management; Humans; Lower Extremity; Lymphedema; Neoplasms; Palliative Medicine;

2015
Toxicology and risk assessment of coumarin: focus on human data.
    Molecular nutrition & food research, 2010, Volume: 54, Issue:2

    Topics: Animals; Biotransformation; Chemical and Drug Induced Liver Injury; Coumarins; Edema; Flavoring Agen

2010
[Lymphedema: which drug therapy?].
    La Revue de medecine interne, 2002, Volume: 23 Suppl 3

    Topics: Anticoagulants; Breast Neoplasms; Coumarins; Diuretics; Female; Flavonoids; Humans; Lymphedema

2002
Pharmacogenomics: its role in re-establishing coumarin as treatment for lymphedema.
    Lymphatic research and biology, 2005,Summer, Volume: 3, Issue:2

    Topics: Aryl Hydrocarbon Hydroxylases; Coumarins; Cytochrome P-450 CYP2A6; Flavonoids; Humans; Lymphedema; M

2005
CYP2A6 polymorphisms: is there a role for pharmacogenomics in preventing coumarin-induced hepatotoxicity in lymphedema patients?
    Pharmacogenomics, 2007, Volume: 8, Issue:2

    Topics: Animals; Chemical and Drug Induced Liver Injury; Coumarins; Humans; Liver Diseases; Lymphedema; Phar

2007
Macrophage and tissue changes in the developmental phases of secondary lymphoedema and during conservative therapy with benzopyrone.
    Archives of histology and cytology, 1990, Volume: 53 Suppl

    Topics: Animals; Cell Count; Coumarins; Humans; Lymphedema; Macrophages

1990

Trials

8 trials available for coumarin and Congenital Familial Lymphedema

ArticleYear
Treatment of filarial lymphoedema and elephantiasis with 5,6-benzo-alpha-pyrone (coumarin).
    BMJ (Clinical research ed.), 1993, Oct-23, Volume: 307, Issue:6911

    Topics: Coumarins; Double-Blind Method; Elephantiasis, Filarial; Female; Filariasis; Humans; Lymphedema; Mal

1993
Reduction of filaritic lymphoedema and elephantiasis by 5,6 benzo-alpha-pyrone (coumarin), and the effects of diethylcarbamazine (DEC).
    Annals of tropical medicine and parasitology, 1993, Volume: 87, Issue:3

    Topics: Adult; Aged; Coumarins; Diethylcarbamazine; Double-Blind Method; Drug Therapy, Combination; Elephant

1993
Treatment of lymphedema of the arms and legs with 5,6-benzo-[alpha]-pyrone.
    The New England journal of medicine, 1993, Oct-14, Volume: 329, Issue:16

    Topics: Arm; Chronic Disease; Coumarins; Double-Blind Method; Female; Follow-Up Studies; Humans; Leg; Lymphe

1993
Treatment of lymphedema by complex physical therapy, with and without oral and topical benzopyrones: what should therapists and patients expect.
    Lymphology, 1996, Volume: 29, Issue:2

    Topics: Administration, Oral; Administration, Topical; Anticoagulants; Arm; Combined Modality Therapy; Couma

1996
The use of 5,6 benzo-[alpha]-pyrone (coumarin) and heating by microwaves in the treatment of chronic lymphedema of the legs.
    Lymphology, 1996, Volume: 29, Issue:3

    Topics: Administration, Oral; Adult; Anticoagulants; Bandages; Chronic Disease; Combined Modality Therapy; C

1996
Lack of effect of coumarin in women with lymphedema after treatment for breast cancer.
    The New England journal of medicine, 1999, Feb-04, Volume: 340, Issue:5

    Topics: Adult; Aged; Aged, 80 and over; Breast Neoplasms; Chronic Disease; Combined Modality Therapy; Coumar

1999
Comparative study of the clinical efficacy of two different coumarin dosages in the management of arm lymphedema after treatment for breast cancer.
    Lymphology, 1999, Volume: 32, Issue:1

    Topics: Arm; Breast Neoplasms; Combined Modality Therapy; Coumarins; Dose-Response Relationship, Drug; Doubl

1999
The effects of 5,6 benzo-[a]-pyrone (coumarin) and DEC on filaritic lymphoedema and elephantiasis in India. Preliminary results.
    Annals of tropical medicine and parasitology, 1989, Volume: 83, Issue:3

    Topics: Analysis of Variance; Coumarins; Diethylcarbamazine; Double-Blind Method; Elephantiasis, Filarial; F

1989

Other Studies

12 other studies available for coumarin and Congenital Familial Lymphedema

ArticleYear
Lympidem (a coumarin derivative) induced reversible hepatotoxicity in an adult Sri Lankan.
    Drug metabolism and drug interactions, 2009, Volume: 24, Issue:1

    Topics: Chemical and Drug Induced Liver Injury; Coumarins; Female; Humans; Lower Extremity; Lymphedema; Midd

2009
Lymphatic research: a global concern.
    Lymphatic research and biology, 2005,Summer, Volume: 3, Issue:2

    Topics: Anticoagulants; Coumarins; Humans; Lymphatic Diseases; Lymphatic System; Lymphedema

2005
[Successful therapy of lymphedema].
    Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al], 1994, Volume: 170, Issue:3

    Topics: Arm; Coumarins; Humans; Leg; Lymphedema

1994
[Contribution of a combination of alpha and beta benzopyrones, flavonoids and natural terpenes in the treatment of lymphedema of the lower limbs at the 2d stage of the surgical classification].
    Minerva cardioangiologica, 1996, Volume: 44, Issue:9

    Topics: Adolescent; Adult; Aged; Anticoagulants; Coumarins; Drainage; Drug Therapy, Combination; Follow-Up S

1996
Coumarin-induced hepatotoxicity.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 1997, Volume: 15, Issue:9

    Topics: Antineoplastic Agents; Breast Neoplasms; Chemical and Drug Induced Liver Injury; Coumarins; Female;

1997
The quality of life after breast cancer--solving the problem of lymphedema.
    The New England journal of medicine, 1999, Feb-04, Volume: 340, Issue:5

    Topics: Breast Neoplasms; Coumarins; Female; Humans; Lymph Node Excision; Lymphedema; Postoperative Complica

1999
The placebo "arm".
    Lymphology, 1999, Volume: 32, Issue:1

    Topics: Coumarins; Dose-Response Relationship, Drug; Female; Humans; Lymphedema; Placebos; Randomized Contro

1999
Guidelines for the surgical management of breast cancer: comment.
    The Australian and New Zealand journal of surgery, 1999, Volume: 69, Issue:10

    Topics: Anticoagulants; Breast Neoplasms; Coumarins; Female; Humans; Lymphedema; Postoperative Complications

1999
Advances in symptom management: lymphedema.
    Clinical journal of oncology nursing, 1999, Volume: 3, Issue:3

    Topics: Adult; Aged; Aged, 80 and over; Anticoagulants; Coumarins; Female; Humans; Lymphedema; Mastectomy; M

1999
Combined coumarin and omental transfer treatments for canine proximal obstructive lymphoedema.
    International journal of experimental pathology, 1991, Volume: 72, Issue:5

    Topics: Animals; Collagen; Combined Modality Therapy; Coumarins; Dogs; Endopeptidases; Extracellular Space;

1991
Coumarin and 7-hydroxycoumarin treatment of canine obstructive lymphoedema.
    Clinical science (London, England : 1979), 1989, Volume: 77, Issue:1

    Topics: Animals; Coumarins; Dogs; Endopeptidases; Hindlimb; Lymph; Lymphedema; Proteins; Skin; Umbelliferone

1989
The effect of coumarin (5,6 benzo-alpha-pyrone) on elicited members of the mononuclear system in dogs with chronic secondary lymphedema.
    Research in experimental medicine. Zeitschrift fur die gesamte experimentelle Medizin einschliesslich experimenteller Chirurgie, 1986, Volume: 186, Issue:2

    Topics: Animals; Chronic Disease; Coumarins; Dogs; Lymphedema; Monocytes; Phagocytosis

1986