cotylenin-a has been researched along with Leukemia--Promyelocytic--Acute* in 2 studies
1 review(s) available for cotylenin-a and Leukemia--Promyelocytic--Acute
| Article | Year |
|---|---|
Cotylenin A--a plant growth regulator as a differentiation-inducing agent against myeloid leukemia.
Acute myeloid leukemia (AML) is characterized by the arrest of differentiation leading to the accumulation of immature cells. This maturation arrest can be reversed by certain agents. Although differentiation therapy for patients with acute promyelocytic leukemia (APL) using all-trans retinoic acid (ATRA) has been established, the clinical response of AML patients other than those with APL to ATRA is limited. We must consider novel therapeutic drugs against other forms of AML for the development of a differentiation therapy for leukemia. Regulators that play an important role in the differentiation and development of plants or invertebrates may also affect the differentiation of human leukemia cells through a common signal transduction system, and might be clinically useful for treating AML. Cotylenin A, a plant growth regulator, is a potent and novel inducer of the monocytic differentiation of human myeloid leukemia cell lines and leukemia cells freshly isolated from AML patients. Topics: Animals; Antigens, Differentiation; Antineoplastic Agents, Phytogenic; Cell Differentiation; Cholecalciferol; Diterpenes; Drug Screening Assays, Antitumor; Drug Synergism; HL-60 Cells; Humans; Leukemia, Myeloid; Leukemia, Promyelocytic, Acute; Mice; Neoplastic Stem Cells; Retinoids; Structure-Activity Relationship; Tretinoin; Tumor Cells, Cultured | 2002 |
1 other study(ies) available for cotylenin-a and Leukemia--Promyelocytic--Acute
| Article | Year |
|---|---|
Treatment of human promyelocytic leukemia in the SCID mouse model with cotylenin A, an inducer of myelomonocytic differentiation of leukemia cells.
Cotylenin A has differentiation-inducing activity in human myeloid leukemia cell lines and leukemic cells that were freshly isolated from acute myeloid leukemia (AML) patients in primary culture. Injection of the human promyelocytic leukemia cell line NB4 into SCID mice resulted in the death of all mice due to leukemia. Administration of cotylenin A significantly prolonged the survival of mice inoculated with NB4 cells. In an in vivo analysis, cotylenin A induced the differentiation of leukemia cells in a retinoid-resistant leukemia model. Cotylenin A may be useful for differentiation therapy of retinoid-resistant leukemia. Topics: Animals; Antineoplastic Agents; Cell Differentiation; Diterpenes; Drug Resistance, Neoplasm; Female; Humans; Leukemia, Promyelocytic, Acute; Mice; Mice, SCID; Neoplasm Transplantation; Retinoids; Survival Analysis; Transplantation, Heterologous; Tumor Cells, Cultured | 2003 |