cotylenin-a and Acute-Disease

Cotylenin A, which has a diterpenoid tricarbocyclic skeleton, has been isolated as a plant growth regulator, has been shown to affect several physiological processes of higher plants and have differentiation-inducing activity in several myeloid leukaemia cell lines. We examined the effect of cotylenin A on the differentiation of leukaemic cells that were freshly isolated from acute myeloid leukaemia (AML) patients in primary culture. Cotylenin A significantly stimulated both functional and morphological differentiation of leukaemia cells in 9 out of 12 cases. This differentiation-inducing activity was more potent than those of all-trans retinoic acid and 1alpha,25-dihydroxyvitamin D3 (VD3). Treatment with a combination of cotylenin A and VD3 was more effective than cotylenin A or VD3 alone at inducing the monocytic differentiation of AML cells.

Topics: Acute Disease; Adult; Aged; Aged, 80 and over; Antigens, CD; Antigens, Differentiation, T-Lymphocyte; Calcitriol; Cell Differentiation; Diterpenes; Drug Synergism; Female; Humans; Lectins, C-Type; Leukemia, Myeloid; Lipopolysaccharide Receptors; Macrophage-1 Antigen; Male; Middle Aged; Plant Growth Regulators; Statistics, Nonparametric; Tretinoin; Tumor Cells, Cultured